Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domainzf-RING_2

RNF223 SCAF11

1.54e-0352212PF13639
DomainRho_GTPase_activation_prot

PLXNA1 SYDE2

4.35e-0388212IPR008936
Domain-

SYT17 SYDE2

1.19e-021482122.60.40.150
Domain-

RNF223 KMT2A SCAF11

1.33e-024492133.30.40.10
DomainZnf_RING/FYVE/PHD

RNF223 KMT2A SCAF11

1.41e-02459213IPR013083
DomainZnf_RING_CS

RNF223 SCAF11

1.43e-02163212IPR017907
DomainC2_dom

SYT17 SYDE2

1.44e-02164212IPR000008
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

SRRM2 MAP4K4 KMT2A ACIN1 MCM4 SCAF11 ZMYM3

6.55e-0777424715302935
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

SRRM2 ACIN1 MCM4 SCAF11 ZMYM3

2.82e-0633224532786267
Pubmed

Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes.

SRRM2 KMT2A ACIN1

3.26e-064224335705031
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

SRRM2 KMT2A ACIN1 MCM4 SCAF11 ZMYM3

4.32e-0665324622586326
Pubmed

Altered expressions and splicing profiles of Acin1 transcripts differentially modulate brown adipogenesis through an alternative splicing mechanism.

MAP4K4 ACIN1

4.56e-06524232629174
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

KMT2A ACIN1 SCAF11 SRSF8

2.51e-0525124431076518
Pubmed

Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.

HIVEP3 KMT2A PLXNA1

3.26e-059024315033168
Pubmed

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

KMT2A ACIN1 ZMYM3

4.88e-0510324332744500
Pubmed

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.

KMT2A ACIN1 MCM4

5.02e-0510424326167872
Pubmed

KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.

SRRM2 ACIN1 SCAF11

9.75e-0513024335545047
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

KMT2A MCM4 SCAF11 ZMYM3

1.44e-0439424427248496
Pubmed

Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.

SRRM2 MAP4K4 ACIN1

1.67e-0415624322952844
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

SRRM2 KMT2A ACIN1 SCAF11 SRSF8 ZMYM3

1.98e-04129424630804502
Pubmed

The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.

SRRM2 ACIN1 SRSF8

2.12e-0416924323084401
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

SRRM2 KMT2A ACIN1 SCAF11 ZMYM3

2.45e-0484724535850772
Pubmed

Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.

SRRM2 ACIN1 MCM4

2.63e-0418224326527279
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

KMT2A ACIN1 MCM4 SCAF11

2.80e-0446924427634302
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

KMT2A ACIN1 SCAF11

3.57e-0420224324639526
Pubmed

Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.

SRRM2 MCM4

4.05e-044324234672947
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

SRRM2 KMT2A ACIN1 MCM4 SCAF11

4.23e-0495424536373674
InteractionSRSF4 interactions

SRRM2 KMT2A ACIN1 SCAF11 SRSF8

1.51e-05300225int:SRSF4
InteractionYWHAG interactions

SRRM2 MAP4K4 KMT2A ACIN1 SCAF11 SRSF8 SYDE2 ZMYM3

3.09e-051248228int:YWHAG
InteractionU2AF2 interactions

SRRM2 ACIN1 SCAF11 SRSF8 SYDE2 CHCHD10

5.32e-05651226int:U2AF2
InteractionH2BC21 interactions

SRRM2 MAP4K4 KMT2A MCM4 SCAF11 ZMYM3

7.71e-05696226int:H2BC21
InteractionSIRT7 interactions

SRRM2 KMT2A ACIN1 MCM4 SCAF11 ZMYM3

1.11e-04744226int:SIRT7
InteractionRAD18 interactions

SRRM2 ACIN1 SCAF11 SRSF8 ZMYM3

1.12e-04457225int:RAD18
InteractionLUC7L interactions

SRRM2 ACIN1 SRSF8 CHCHD10

1.25e-04242224int:LUC7L
InteractionSRPK1 interactions

SRRM2 ACIN1 MCM4 SCAF11 SRSF8

1.37e-04477225int:SRPK1
InteractionZMYND11 interactions

SRRM2 KMT2A ACIN1

1.42e-0494223int:ZMYND11
InteractionH2BC4 interactions

SRRM2 MAP4K4 KMT2A MCM4

1.62e-04259224int:H2BC4
InteractionSRSF6 interactions

SRRM2 KMT2A ACIN1 SCAF11 SRSF8

1.76e-04503225int:SRSF6
InteractionPRPF40B interactions

SRRM2 RGS9

2.36e-0421222int:PRPF40B
InteractionSUMO2 interactions

SRRM2 ACIN1 MCM4 SCAF11 ZMYM3

3.71e-04591225int:SUMO2
InteractionCHD4 interactions

SRRM2 KMT2A ACIN1 MCM4 SCAF11 ZMYM3

3.93e-04938226int:CHD4
Cytoband1p22.3

LPAR3 SYDE2

6.01e-05222421p22.3
CytobandEnsembl 112 genes in cytogenetic band chr1p22

LPAR3 SYDE2

2.34e-03137242chr1p22
GeneFamilyRing finger proteins

RNF223 SCAF11

2.70e-0227517258
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SRRM2 KMT2A ACIN1 SCAF11

3.76e-0620024412f1685ce8f218433068e090c9d839cd5a1910bf
DiseaseNeurodevelopmental Disorders

HIVEP3 KMT2A

2.18e-0393222C1535926
DiseaseSchizophrenia

NRXN2 KMT2A RGS9 CACNG8

3.79e-03883224C0036341
Diseaserheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement

HIVEP3 SCAF11

7.07e-03170222EFO_0000685, EFO_0007791, EFO_0007837
Diseaseuric acid measurement

NRXN2 QRICH2 ZMYM3

1.01e-02610223EFO_0004761

Protein segments in the cluster

PeptideGeneStartEntry
RPKMGSRSTSESRSR

ACIN1

626

Q9UKV3
SERRNSLRRMSSSFP

QRICH2

1011

Q9H0J4
STLPFMRRHLRSSPS

RGS9

431

O75916
MSSPASTPSRRGSRR

MCM4

1

P33991
RTTSRSPVLSRRDSP

MAP4K4

626

O95819
TPRQRSESLSSRSTM

GPR61

251

Q9BZJ8
MRSSSLPGARSPRRN

MED14OS

1

P0DP75
PSSMSEPRRGKARRS

PSMG3-AS1

131

Q96PY0
MLRTASSPDSLRSRT

PLXNA1

1626

Q9UIW2
TMATTTTRRGRSPTL

NRXN2

1371

Q9P2S2
SPHTSGSISRRRTPM

LPAR3

221

Q9UBY5
MATTTTRRGRSPTLR

NRXN2

326

P58401
RRRSRSSSRSSEPSP

CACNG8

271

Q8WXS5
MPRGSRSAASRPASR

CHCHD10

1

Q8WYQ3
SEPRSPSHSMRTRSG

KMT2A

746

Q03164
RTMTSRASELSPGRS

FLAD1

96

Q8NFF5
RRKPAMTTPTRRSTR

SCAF11

311

Q99590
LRTVRRRSVPSSSMP

OBSCN-AS1

11

Q96MR7
TPRMRPSCSRSLESL

SYDE2

76

Q5VT97
TPSRRMGRSRSPATA

SRRM2

476

Q9UQ35
TSPVTRRRSRSRTSP

SRRM2

1986

Q9UQ35
RSRTPPSAPSQSRMT

SRRM2

2406

Q9UQ35
QSRMTSERAPSPSSR

SRRM2

2416

Q9UQ35
TRRISSLESRRPSSP

SYT17

106

Q9BSW7
RSRSRSSSMTRSPPR

SRSF8

241

Q9BRL6
RRSSSIASMPRSPSS

RNF223

16

E7ERA6
MRRPSTASLTRTPSR

nan

1

Q9UF83
RTPSRASPTRMPSRA

nan

11

Q9UF83
RTLPRASLMRTPTRA

nan

46

Q9UF83
PRRSSLSRRSSMESP

HIVEP3

486

Q5T1R4
RSPRMSLRSSVSQRA

ZMYM3

286

Q14202