Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninositol 1,4,5-trisphosphate-gated calcium channel activity

ITPR1 ITPR3

7.46e-063322GO:0005220
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

ITPR1 ITPR3

2.24e-0414322GO:0070679
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

ITPR1 ITPR3

3.75e-0418322GO:0015278
GeneOntologyMolecularFunctionamino acid:sodium symporter activity

SLC6A1 SLC6A9

6.16e-0423322GO:0005283
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC6A1 SLC6A9 SLC6A19

6.27e-04105323GO:0015171
GeneOntologyMolecularFunctionamino acid:monoatomic cation symporter activity

SLC6A1 SLC6A9

9.83e-0429322GO:0005416
GeneOntologyMolecularFunctionligand-gated calcium channel activity

ITPR1 ITPR3

1.12e-0331322GO:0099604
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

ITPR1 ITPR3

1.27e-0333322GO:0005217
GeneOntologyMolecularFunctionorganic acid:sodium symporter activity

SLC6A1 SLC6A9

1.43e-0335322GO:0005343
GeneOntologyMolecularFunctionsymporter activity

SLC6A1 SLC6A9 SLC6A19

1.76e-03150323GO:0015293
GeneOntologyMolecularFunctionneutral L-amino acid transmembrane transporter activity

SLC6A9 SLC6A19

1.96e-0341322GO:0015175
GeneOntologyMolecularFunctionserine-type endopeptidase activity

TPSD1 TMPRSS2 PRSS12

3.43e-03190323GO:0004252
GeneOntologyMolecularFunctionO-acyltransferase activity

CPT1A MOGAT3

4.02e-0359322GO:0008374
GeneOntologyMolecularFunctionserine-type peptidase activity

TPSD1 TMPRSS2 PRSS12

4.36e-03207323GO:0008236
GeneOntologyMolecularFunctionserine hydrolase activity

TPSD1 TMPRSS2 PRSS12

4.66e-03212323GO:0017171
GeneOntologyMolecularFunctionendopeptidase activity

TPSD1 TMPRSS2 ZMPSTE24 PRSS12

4.73e-03430324GO:0004175
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC6A1 SLC6A9 ITPR1 ITPR3

6.23e-03465324GO:0046873
GeneOntologyBiologicalProcessgastrulation with mouth forming second

CHRD MEGF8 CRB2

2.15e-0535323GO:0001702
GeneOntologyCellularComponentplatelet dense tubular network membrane

ITPR1 ITPR3

8.64e-059332GO:0031095
GeneOntologyCellularComponentplatelet dense tubular network

ITPR1 ITPR3

1.32e-0411332GO:0031094
MousePhenoabnormal food preference

SLC6A1 PRLHR ITPR3

7.61e-0619293MP:0001432
DomainNA_NEUROTRAN_SYMP_3

SLC6A1 SLC6A9 SLC6A19

4.78e-0619333PS50267
DomainSNF

SLC6A1 SLC6A9 SLC6A19

4.78e-0619333PF00209
DomainNa/ntran_symport

SLC6A1 SLC6A9 SLC6A19

4.78e-0619333IPR000175
DomainNA_NEUROTRAN_SYMP_1

SLC6A1 SLC6A9 SLC6A19

4.78e-0619333PS00610
DomainInsP3_rcpt-bd

ITPR1 ITPR3

9.07e-063332IPR000493
DomainRIH_assoc

ITPR1 ITPR3

4.52e-056332PF08454
DomainRIH_assoc-dom

ITPR1 ITPR3

4.52e-056332IPR013662
DomainRYDR_ITPR

ITPR1 ITPR3

4.52e-056332PF01365
DomainRIH_dom

ITPR1 ITPR3

4.52e-056332IPR000699
DomainIns145_P3_rcpt

ITPR1 ITPR3

4.52e-056332IPR014821
DomainRyanodine_recept-rel

ITPR1 ITPR3

4.52e-056332IPR015925
DomainIns145_P3_rec

ITPR1 ITPR3

4.52e-056332PF08709
Domain-

ITPR1 ITPR3

4.52e-0563321.25.10.30
DomainMIR

ITPR1 ITPR3

1.35e-0410332PS50919
DomainMIR

ITPR1 ITPR3

1.35e-0410332PF02815
DomainMIR

ITPR1 ITPR3

1.35e-0410332SM00472
DomainMIR_motif

ITPR1 ITPR3

1.35e-0410332IPR016093
DomainNA_NEUROTRAN_SYMP_2

SLC6A1 SLC6A9

4.55e-0418332PS00754
DomainTRYPSIN_SER

TPSD1 TMPRSS2 PRSS12

5.32e-0490333IPR033116
DomainSRCR

TMPRSS2 PRSS12

6.23e-0421332PF00530
DomainTRYPSIN_HIS

TPSD1 TMPRSS2 PRSS12

7.88e-04103333IPR018114
DomainTRYPSIN_SER

TPSD1 TMPRSS2 PRSS12

8.57e-04106333PS00135
DomainTRYPSIN_HIS

TPSD1 TMPRSS2 PRSS12

8.80e-04107333PS00134
DomainSR

TMPRSS2 PRSS12

8.85e-0425332SM00202
Domain-

TMPRSS2 PRSS12

8.85e-04253323.10.250.10
DomainSRCR_1

TMPRSS2 PRSS12

9.58e-0426332PS00420
DomainSRCR-like_dom

TMPRSS2 PRSS12

9.58e-0426332IPR017448
DomainSRCR_2

TMPRSS2 PRSS12

9.58e-0426332PS50287
DomainPeptidase_S1A

TPSD1 TMPRSS2 PRSS12

1.03e-03113333IPR001314
DomainSRCR

TMPRSS2 PRSS12

1.03e-0327332IPR001190
DomainTRYPSIN_DOM

TPSD1 TMPRSS2 PRSS12

1.08e-03115333PS50240
DomainTryp_SPc

TPSD1 TMPRSS2 PRSS12

1.14e-03117333SM00020
DomainTrypsin

TPSD1 TMPRSS2 PRSS12

1.26e-03121333PF00089
DomainTrypsin_dom

TPSD1 TMPRSS2 PRSS12

1.26e-03121333IPR001254
DomainPeptidase_S1_PA

TPSD1 TMPRSS2 PRSS12

1.32e-03123333IPR009003
DomainCys-rich_flank_reg_C

LRFN4 LRFN3

1.10e-0290332IPR000483
DomainLRRCT

LRFN4 LRFN3

1.10e-0290332SM00082
DomainEGF_Ca-bd_CS

MEGF8 CRB2

1.27e-0297332IPR018097
PathwayREACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS

SLC6A1 SLC6A9 SLC6A19

5.95e-0619273MM15107
PathwayREACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS

SLC6A1 SLC6A9 SLC6A19

5.95e-0619273M27362
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY

ITPR1 ITPR3

3.52e-055272M49000
PathwayKEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR3

5.27e-056272M47960
PathwayKEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR3

1.26e-049272M47852
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR3

1.57e-0410272M47661
PathwayWP_SARSCOV2_AND_COVID19_PATHWAY

TMPRSS2 SLC6A19

1.57e-0410272M40050
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR3

1.92e-0411272M49033
PathwayREACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION

ITPR1 ITPR3

1.92e-0411272M27466
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR3

2.72e-0413272M47751
PathwayKEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR3

2.72e-0413272M47656
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR3

2.72e-0413272M47696
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR1 ITPR3

2.72e-0413272MM14553
PathwayWP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY

FGB ITPR1 ITPR3

3.71e-0474273M48080
PathwayREACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS

SLC6A1 SLC6A9 SLC6A19

4.01e-0476273MM15072
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR1 ITPR3

4.17e-0416272M26945
PathwayREACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS

SLC6A1 SLC6A9 SLC6A19

5.38e-0484273M27334
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR3

5.92e-0419272M47760
PathwayREACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION

ITPR1 ITPR3

5.92e-0419272M27423
PathwayREACTOME_ATTACHMENT_AND_ENTRY

TMPRSS2 GPC2

5.92e-0419272M41729
PathwayKEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR3

5.92e-0419272M47733
PathwayREACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES

LRFN4 LRFN3

6.57e-0420272MM15485
PathwayKEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR3

6.57e-0420272M47688
PathwayREACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES

LRFN4 LRFN3

7.25e-0421272M27736
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR3

7.25e-0421272M47689
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR3

7.97e-0422272M47690
PathwayKEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR3

7.97e-0422272M47675
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR3

8.72e-0423272M47676
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

ITPR1 ITPR3

1.03e-0325272MM14511
PathwayWP_COVID19_STRUCTURAL_COVERAGE_MAP

CMTR1 SLC6A19

1.12e-0326272M48318
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

ITPR1 ITPR3

1.20e-0327272M12123
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

ITPR1 ITPR3

1.20e-0327272MM15053
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

ITPR1 ITPR3

1.29e-0328272M924
PathwayWP_FRAGILE_X_SYNDROME

SLC6A1 CPT1A ITPR1

1.55e-03121273M39804
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

ITPR1 ITPR3

1.69e-0332272MM14983
PathwaySIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES

ITPR1 ITPR3

2.14e-0336272M1315
PathwayWP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION

ITPR1 ITPR3

2.14e-0336272M39831
PathwayREACTOME_EARLY_SARS_COV_2_INFECTION_EVENTS

TMPRSS2 GPC2

2.26e-0337272M45028
PathwayWP_NRF2_PATHWAY

SLC6A1 SLC6A9 SLC6A19

2.40e-03141273M39454
PathwayREACTOME_DAG_AND_IP3_SIGNALING

ITPR1 ITPR3

2.77e-0341272M512
PathwayWP_NUCLEAR_RECEPTORS_METAPATHWAY

SLC6A1 SLC6A9 CPT1A SLC6A19

2.83e-03314274M39428
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

ITPR1 ITPR3

2.90e-0342272M791
PathwayWP_RENINANGIOTENSINALDOSTERONE_SYSTEM_RAAS

ITPR1 ITPR3

3.18e-0344272M39845
PathwaySIG_CHEMOTAXIS

ITPR1 ITPR3

3.32e-0345272M5193
PathwaySIG_BCR_SIGNALING_PATHWAY

ITPR1 ITPR3

3.47e-0346272M8626
PathwayKEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR3

4.09e-0350272M47951
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

ITPR1 ITPR3

4.58e-0353272MM15716
PathwayREACTOME_ION_HOMEOSTASIS

ITPR1 ITPR3

4.75e-0354272MM15202
PathwayREACTOME_ION_HOMEOSTASIS

ITPR1 ITPR3

4.75e-0354272M27460
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

ITPR1 ITPR3

4.75e-0354272M26911
PathwayKEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR3

4.93e-0355272M47952
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

ITPR1 ITPR3

6.03e-0361272MM15071
PathwayREACTOME_CA2_PATHWAY

ITPR1 ITPR3

6.22e-0362272M27321
PathwayREACTOME_SIGNALING_BY_GPCR

C5AR2 PLPPR3 PRLHR ITPR1 ITPR3

6.94e-03646275MM14962
PathwayREACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES

LRFN4 LRFN3

7.23e-0367272MM15327
Pubmed

Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor.

ITPR1 ITPR3

8.73e-0723328663526
Pubmed

The Pro335 --> Leu polymorphism of type 3 inositol 1,4,5-trisphosphate receptor found in mouse inbred lines results in functional change.

ITPR1 ITPR3

8.73e-07233215890645
Pubmed

Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening.

ITPR1 ITPR3

8.73e-07233220813840
Pubmed

Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells.

ITPR1 ITPR3

8.73e-0723327559486
Pubmed

Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating.

ITPR1 ITPR3

8.73e-07233220843799
Pubmed

Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.

ITPR1 ITPR3

8.73e-0723321374893
Pubmed

Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling.

ITPR1 ITPR3

8.73e-07233214707143
Pubmed

The repertoire of solute carriers of family 6: identification of new human and rodent genes.

SLC6A1 SLC6A9 SLC6A19

1.02e-062133316125675
Pubmed

Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.

ITPR1 ITPR3

2.62e-06333231979185
Pubmed

Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.

ITPR1 ITPR3

2.62e-06333210874040
Pubmed

Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.

ITPR1 ITPR3

2.62e-0633329808793
Pubmed

Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.

ITPR1 ITPR3

2.62e-06333224904548
Pubmed

Ubiquitination and proteasomal degradation of endogenous and exogenous inositol 1,4,5-trisphosphate receptors in alpha T3-1 anterior pituitary cells.

ITPR1 ITPR3

2.62e-06333212421829
Pubmed

Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.

ITPR1 ITPR3

2.62e-06333220395455
Pubmed

Functional analysis of the inhibitory neurotransmitter transporters GlyT1, GAT-1, and GAT-3 in astrocytes of the lateral superior olive.

SLC6A1 SLC6A9

2.62e-06333225103283
Pubmed

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR3

2.62e-06333217327232
Pubmed

Identification of KRAP-expressing cells and the functional relevance of KRAP to the subcellular localization of IP3R in the stomach and kidney.

ITPR1 ITPR3

2.62e-06333222992961
Pubmed

Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.

ITPR1 ITPR3

2.62e-06333217437169
Pubmed

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.

ITPR1 ITPR3

2.62e-06333216014380
Pubmed

Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.

ITPR1 ITPR3

2.62e-06333218194433
Pubmed

Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.

ITPR1 ITPR3

2.62e-06333217890015
Pubmed

Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.

ITPR1 ITPR3

2.62e-06333218547250
Pubmed

Selected SALM (synaptic adhesion-like molecule) family proteins regulate synapse formation.

LRFN4 LRFN3

2.62e-06333220410109
Pubmed

Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.

ITPR1 ITPR3

2.62e-06333236350267
Pubmed

Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels.

ITPR1 ITPR3

2.62e-06333212032348
Pubmed

Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis.

ITPR1 ITPR3

2.62e-06333218250332
Pubmed

IP3 receptors regulate vascular smooth muscle contractility and hypertension.

ITPR1 ITPR3

2.62e-06333227777977
Pubmed

The versatility and universality of calcium signalling.

ITPR1 ITPR3

2.62e-06333211413485
Pubmed

Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.

ITPR1 ITPR3

2.62e-06333223983250
Pubmed

Expression of functional inhibitory neurotransmitter transporters GlyT1, GAT-1, and GAT-3 by astrocytes of inferior colliculus and hippocampus.

SLC6A1 SLC6A9

2.62e-06333229370841
Pubmed

Synaptic adhesion-like molecules (SALMs) promote neurite outgrowth.

LRFN4 LRFN3

2.62e-06333218585462
Pubmed

Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.

ITPR1 ITPR3

2.62e-0633329858485
Pubmed

Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR3

2.62e-06333226009177
Pubmed

Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.

ITPR1 ITPR3

2.62e-06333217581770
Pubmed

Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.

ITPR1 ITPR3

2.62e-06333220427533
Pubmed

Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.

ITPR1 ITPR3

2.62e-06333218241669
Pubmed

Receptor-activated single channels in intact human platelets.

ITPR1 ITPR3

2.62e-0633321693919
Pubmed

Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.

ITPR1 ITPR3

2.62e-06333219068129
Pubmed

Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

ITPR1 ITPR3

2.62e-06333223955339
Pubmed

Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.

ITPR1 ITPR3

5.23e-06433225215520
Pubmed

Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.

ITPR1 ITPR3

5.23e-06433214685260
Pubmed

Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.

ITPR1 ITPR3

5.23e-06433221424589
Pubmed

Exocytosis regulates trafficking of GABA and glycine heterotransporters in spinal cord glutamatergic synapses: a mechanism for the excessive heterotransporter-induced release of glutamate in experimental amyotrophic lateral sclerosis.

SLC6A1 SLC6A9

5.23e-06433225497732
Pubmed

Ins(1,4,5)P3 receptor-mediated Ca2+ signaling and autophagy induction are interrelated.

ITPR1 ITPR3

5.23e-06433222082873
Pubmed

IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.

ITPR1 ITPR3

5.23e-06433228419336
Pubmed

Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR3

5.23e-06433211163362
Pubmed

IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.

ITPR1 ITPR3

5.23e-06433235494252
Pubmed

Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.

ITPR1 ITPR3

5.23e-06433228615414
Pubmed

Stabilization of cortical actin induces internalization of transient receptor potential 3 (Trp3)-associated caveolar Ca2+ signaling complex and loss of Ca2+ influx without disruption of Trp3-inositol trisphosphate receptor association.

ITPR1 ITPR3

5.23e-06433211524429
Pubmed

Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.

ITPR1 ITPR3

5.23e-06433210828023
Pubmed

The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage.

ITPR1 ITPR3

5.23e-06433223884412
Pubmed

InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.

ITPR1 ITPR3

8.72e-06533221568942
Pubmed

The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor.

ITPR1 ITPR3

8.72e-06533219706527
Pubmed

Widespread expression of inositol 1,4,5-trisphosphate receptor type 1 gene (Insp3r1) in the mouse central nervous system.

ITPR1 ITPR3

8.72e-0653328081710
Pubmed

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum.

ITPR1 ITPR3

8.72e-06533215613488
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

ITPR1 ITPR3

1.31e-05633223463619
Pubmed

Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.

ITPR1 ITPR3

1.31e-05633221762810
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

ITPR1 ITPR3

1.31e-05633216844763
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

ITPR1 ITPR3

1.31e-05633220519450
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

ITPR1 ITPR3

1.31e-05633225966694
Pubmed

Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells.

ITPR1 ITPR3

1.31e-05633217416589
Pubmed

Comparative analysis of structure, expression and PSD95-binding capacity of Lrfn, a novel family of neuronal transmembrane proteins.

LRFN4 LRFN3

1.83e-05733216828986
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

ITPR1 ITPR3

1.83e-05733211860456
Pubmed

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

ITPR1 ITPR3

1.83e-05733222495310
Pubmed

A novel family of adhesion-like molecules that interacts with the NMDA receptor.

LRFN4 LRFN3

1.83e-05733216495444
Pubmed

Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx.

ITPR1 ITPR3

3.13e-05933215623527
Pubmed

Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.

ITPR1 ITPR3

3.13e-05933225737585
Pubmed

Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds.

CHRD FMN1

3.91e-051033210524628
Pubmed

Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development.

ITPR1 ITPR3

4.78e-051133227514653
Pubmed

Conditional deletion of activating protein 2alpha (AP-2alpha) in the developing retina demonstrates non-cell-autonomous roles for AP-2alpha in optic cup development.

SLC6A1 SLC6A9

6.77e-051333217724084
Pubmed

Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers.

ITPR1 ITPR3

7.89e-051433234630045
Pubmed

Inositol 1,4,5-trisphosphate receptors are essential for the development of the second heart field.

ITPR1 ITPR3

7.89e-051433221382375
Pubmed

Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.

ITPR1 ITPR3

9.10e-051533228578927
Pubmed

Molecular genetics of hereditary spinocerebellar ataxia: mutation analysis of spinocerebellar ataxia genes and CAG/CTG repeat expansion detection in 225 Italian families.

PLEKHG4 ITPR1

1.18e-041733215148151
Pubmed

Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors.

SLC6A1 SLC6A9

1.48e-041933215363391
Pubmed

Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice.

TMPRSS2 PRSS12

1.81e-042133219592578
Pubmed

Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation.

HMX1 PRSS12

1.99e-042233214645517
Pubmed

The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity.

ITPR1 ITPR3

1.99e-042233211696558
Pubmed

Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.

ITPR1 ITPR3

2.38e-042433210843712
Pubmed

SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion.

LRFN4 LRFN3

2.58e-042533227480238
Pubmed

Overlapping expression patterns and redundant roles for AP-2 transcription factors in the developing mammalian retina.

SLC6A1 SLC6A9

2.58e-042533222411557
Pubmed

The c-Ski family member and transcriptional regulator Corl2/Skor2 promotes early differentiation of cerebellar Purkinje cells.

SKOR2 ITPR1

3.25e-042833224491816
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

TMPRSS2 GPRC5C ZMPSTE24 MEGF8 CRB2 SLC6A19

3.45e-04101633619056867
Pubmed

Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation.

ITPR1 ITPR3

3.49e-042933232123907
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

FGB TMPRSS2 GPRC5C EPX MEGF8 CRB2

4.54e-04107033623533145
Pubmed

Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.

LRFN4 LRFN3

4.81e-043433218848646
Pubmed

Role of ADTRP (Androgen-Dependent Tissue Factor Pathway Inhibitor Regulating Protein) in Vascular Development and Function.

FGB TPSD1

5.39e-043633230571485
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

ITPR1 ITPR3

6.01e-043833230786075
Pubmed

Prospective isolation and global gene expression analysis of definitive and visceral endoderm.

TMPRSS2 GPRC5C

8.80e-044633217328885
Cytoband11q13.2

LRFN4 CPT1A

5.31e-044733211q13.2
GeneFamilyInositol 1,4,5-triphosphate receptors|Protein phosphatase 1 regulatory subunits

ITPR1 ITPR3

5.96e-063262297
GeneFamilyProteases, serine

TMPRSS2 PRSS12

3.68e-0363262738
GeneFamilySolute carriers

SLC6A1 SLC6A9 SLC6A19

1.85e-02395263752
GeneFamilyFibronectin type III domain containing

LRFN4 LRFN3

2.20e-02160262555
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

LRFN4 LRFN3

2.23e-02161262593
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

ITPR1 ITPR3

2.77e-02181262694
CoexpressionCHESLER_BRAIN_D6MIT150_QTL_CIS

SLC6A1 ITPR1

2.30e-056332MM607
CoexpressionCHESLER_BRAIN_D6MIT150_QTL_CIS

SLC6A1 ITPR1

2.30e-056332M12143
CoexpressionESC_V6.5_UP_LATE.V1_UP

FGB TMPRSS2 GPRC5C PRSS12

8.20e-05184334M2772
CoexpressionESC_J1_UP_LATE.V1_UP

FGB TMPRSS2 GPRC5C PRSS12

8.55e-05186334M2768
CoexpressionGSE24210_CTRL_VS_IL35_TREATED_TCONV_CD4_TCELL_UP

MED13L CMTR1 ITPR1 ITPR3

1.13e-04200334M7841
ToppCell367C-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

C5AR2 TPSD1 FMN1

5.06e-0597333a1279377bf0ee5662db8b9303f5f1fd418dee6df
ToppCell367C-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

C5AR2 TPSD1 FMN1

5.06e-059733312cbd03b33e76e5e471bbee2a9c11f27e8b21123
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Slc17a7.Cplx3_(Cortical_subplate)|Striatum / BrainAtlas - Mouse McCarroll V32

EPX PLEKHG4 PRSS12

6.22e-0510433359e982b521610af0532c63b2caf934fa65644b0b
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Slc17a7.Cplx3_(Cortical_subplate)--|Striatum / BrainAtlas - Mouse McCarroll V32

EPX PLEKHG4 PRSS12

6.22e-051043337642c6ac1a51b431a8d48d35520930c072a3710e
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Slc17a7.Cplx3_(Cortical_subplate)-|Striatum / BrainAtlas - Mouse McCarroll V32

EPX PLEKHG4 PRSS12

6.22e-05104333016704f1d1c43e6d4067ad1d81c22cc660e605d0
ToppCellE18.5-samps-Mesenchymal-Pericyte-pericyte_D|E18.5-samps / Age Group, Lineage, Cell class and subclass

GPC2 DHRS2 FMN1

1.81e-04149333dcf68eb25733b5db2893728fe4dca5c7267eb58c
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

GPR135 MEGF8 PRSS12

1.95e-04153333e7d20c88466ff81db613869cf7a6a4bb95fd6c2f
ToppCellfacs-Marrow-T_cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A1 SLC6A9 FMN1

2.07e-041563335caefdc6cc86f2ac52abe8c8da821db14f476915
ToppCellfacs-Marrow-T_cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A1 SLC6A9 FMN1

2.07e-04156333758f57dc10fc5cad200bf5b310c10ec9b1405f23
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal-GABAergic_neurons|GW16 / Sample Type, Dataset, Time_group, and Cell type.

SLC6A1 PRLHR ITPR3

2.39e-041643334d7b2d0980fb4f47721fa2891151e2bd892ccb91
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC6A1 CHRD SLC6A9

2.71e-04171333285533ca2a6a411773313166bee35542f34d1a3c
ToppCell368C-Myeloid-Mast_cell|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

TPSD1 PLEKHG4 PRSS12

2.80e-041733338cffb4a37d30b6626188309b868ac4a62e91262f
ToppCell368C-Myeloid-Mast_cell-|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

TPSD1 PLEKHG4 PRSS12

2.80e-04173333fb87ea74bf70aa83b458edf728c81857c8b8eb96
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPRC5C PRLHR DHRS2

2.95e-04176333b81e5d23b31cefc8d374ef403e21acc390c14a80
ToppCellfacs-Lung-Endomucin-24m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPRC5C PRLHR DHRS2

2.95e-04176333057d2759fdc67176c25802b57a78064d8cc93205
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PRLHR DHRS2 SLC6A19

2.99e-0417733343dce527392f3b8364bb6a55268ce9d6518d3a29
ToppCell5'-GW_trimst-1-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FGB GPR135 DHRS2

3.20e-04181333c1203787cc3f968147fabdd3c646a04be96f6552
ToppCell5'-GW_trimst-1-SmallIntestine-Epithelial-mature_enterocytic|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FGB GPR135 DHRS2

3.20e-04181333f7258af89f4cc89446ff6754bdaa769320af95d6
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC6A1 PRSS12 ITPR3

3.30e-04183333f8b636391f752e379a5c5575fd898bdf0907a3b8
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPRC5C PRSS12 SLC6A19

3.30e-04183333d26c7b79895de28961b8d68351f28d4bb531c75c
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A9 GPRC5C FMN1

3.30e-04183333919c9861073d12fd12aecd7469b1478b13838c43
ToppCelldroplet-Heart-4Chambers-21m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGB TMPRSS2 DHRS2

3.30e-04183333a046b569bc10083d471b420eb2c6fee93437602d
ToppCelldroplet-Heart-4Chambers-21m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGB TMPRSS2 DHRS2

3.30e-041833334de2082dca2569d3aac3c9b466f27971c82d302b
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPRC5C PRSS12 SLC6A19

3.35e-041843333da93e7d8b62463e307cc0425c47dbd3bef66799
ToppCelldroplet-Limb_Muscle-nan-3m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A1 GPR135 DHRS2

3.41e-04185333554c5d812197fbf66bf279fcc953277e926ade15
ToppCellfacs-Heart-LV-24m-Myeloid-macrophage|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGB TMPRSS2 FMN1

3.41e-04185333a835f821a5e6568d648df831ec4c2d0048d67093
ToppCellfacs-Heart-LV-24m-Myeloid-macrophage|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGB TMPRSS2 FMN1

3.41e-04185333386b08bcb304db543e3c5ff75f85e99bf0c592df
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC6A1 SLC6A9 ITPR1

3.46e-041863334780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCellLPS-antiTNF-Epithelial_alveolar|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TMPRSS2 GPRC5C FMN1

3.52e-04187333201ff693e4756ee3e44762885b3a303a77eb535b
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TMPRSS2 FMN1 ITPR3

3.52e-041873335df9e1f5ca32217af255e76e6fb5afa346337811
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

SLC6A1 CHRD SLC6A9

3.57e-04188333ee151792c7ac9afe820f1a281c6dab383799f358
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC6A1 SLC6A9 GPRC5C

3.57e-04188333c2321a3a1d9603f8b4b4fc09707eb32ec1e04f3f
ToppCellAdult|World / Lineage, Cell type, age group and donor

TMPRSS2 CPT1A FMN1

3.63e-041893335cd285bfad973125d46d704fec18b21266a63379
ToppCellpdx-Tumor_cells-T8|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

SLC6A1 CPT1A MOGAT3

3.68e-04190333b05db0de9b6ae01dd30074453f7de44f7397631e
ToppCellfacs-Heart-LV-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHRD GPRC5C ITPR1

3.74e-04191333b7a57691a4742070cee640e285c1f4d0da95baf1
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TMPRSS2 FMN1 ITPR3

3.80e-04192333fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FGB MOGAT3 SLC6A19

3.80e-041923333e1a4cb0d83efd502c8613d41a1692bdda5860ed
ToppCell356C-Epithelial_cells|356C / Donor, Lineage, Cell class and subclass (all cells)

TMPRSS2 GPRC5C ITPR3

3.97e-04195333d913d0a6c4797d9a873ddea6f340c3f152da1cf3
ToppCell(7)_Epithelial-A_(AT2)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

TMPRSS2 GPRC5C ITPR3

3.97e-04195333c9a6c65ee18d83bf34a4713d306a6e30db1325c2
ToppCellBronchial-NucSeq-Stromal-Peri/Epineurial_|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PLPPR3 LRFN4 MOGAT3

4.09e-04197333ee8f7def9d5af7b1e636830a4ea1da158d02f25a
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC6A1 SLC6A9 GPRC5C

4.16e-041983333222d064b6ecab0caa450a59fc1dc79e26fc6fd5
ToppCellBiopsy_Control_(H.)-Epithelial-AT2|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

TMPRSS2 GPRC5C ITPR3

4.22e-041993335323d49d3be980605b3e609b7f03bddba6e50e8a
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Type_2_alveolar|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

TMPRSS2 GPRC5C ITPR3

4.22e-04199333e28ace2ca680c6154398e17110aa1838dd7a5548
ToppCellParenchyma_Control_(B.)-Epithelial-TX-AT2-2|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

TMPRSS2 GPRC5C ITPR3

4.28e-0420033335c05cae30cd6b323d2662f1396ddeab08bc75fc
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-AT2-2-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TMPRSS2 GPRC5C ITPR3

4.28e-042003333c251ad03fbbdae91dfd9037880ba43adbb03807
ToppCellLung_Parenchyma-Control-Epithelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

TMPRSS2 GPRC5C ITPR3

4.28e-04200333c2bde99b3bc7a8740441c1a0c1394892b940b857
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-AT2-2|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

TMPRSS2 GPRC5C ITPR3

4.28e-04200333c905451425d1c24773bb0ca69bcf0309b277d2f1
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SLC6A1 SLC6A9 ITPR1

4.28e-04200333f599e4b051ac3dad11ad437e98dc8ea6754cca53
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SLC6A1 SLC6A9 ITPR1

4.28e-04200333a3a1e35934d676c39f917652e50c502cb2f613c1
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-AT2-1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TMPRSS2 GPRC5C ITPR3

4.28e-0420033365c83a3f6ee2a10bcb5b95076696232c6373a7b4
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-AT2-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

TMPRSS2 GPRC5C ITPR3

4.28e-0420033340e969883bc302e8fbc6b6ab9814529dc1472902
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SLC6A1 SLC6A9 ITPR1

4.28e-04200333c06426f877919bdd267ea2fd7e7973c6619832ae
ToppCellParenchyma_Control_(B.)-Epithelial-TX|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

TMPRSS2 GPRC5C ITPR3

4.28e-042003339970e9bde6aa2ff3aef60dcb065ff15b7463e147
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

TMPRSS2 GPRC5C ITPR3

4.28e-042003333ff9abd5e07780a59d5571da906fa15f00a1d5c2
ToppCellParenchyma_Control_(B.)-Epithelial-TX-AT2-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

TMPRSS2 GPRC5C ITPR3

4.28e-04200333ad9cdc82a647d379abc713a56db0e11bb6494106
ToppCellBiopsy_Other_PF-Epithelial|Biopsy_Other_PF / Sample group, Lineage and Cell type

TMPRSS2 GPRC5C ITPR3

4.28e-042003331ef4d5ae698fa721e0f510bf0d918bd8d3b00591
ToppCellLPS_IL1RA-Mesenchymal_myocytic|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SLC6A1 SLC6A9 ITPR1

4.28e-0420033377631c471cc5d453a749784f838cfa6408caf09b
ToppCellParenchymal-10x5prime-Stromal-Peri/Epineurial_|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CHRD GPR135 LRFN3

4.28e-042003334c3c11dd5e71ebc3d62264eeaeb71a850b149779
DrugIsocaffeine

ITPR1 ITPR3

2.04e-062332CID000001326
Drugadenophostin B

ITPR1 ITPR3

2.04e-062332CID000656722
Drugbenzene 1,2,4-trisphosphate

ITPR1 ITPR3

2.04e-062332CID000192376
Drug5-deoxy-5-fluoro-myo-inositol

ITPR1 ITPR3

6.11e-063332CID000195110
DrugAC1O43P4

EPX ITPR1 ITPR3

6.24e-0625333CID006323279
DrugTyloxapol [25301-02-4]; Up 200; 4uM; PC3; HT_HG-U133A

C5AR2 FGB SLC6A9 CPT1A EPX

9.21e-061983354611_UP
DrugCHEBI:697555

ITPR1 ITPR3

1.22e-054332CID009578246
DrugAC1Q7BER

ITPR1 ITPR3

3.04e-056332CID000005702
Drug3-F-InsP3

ITPR1 ITPR3

4.26e-057332CID003035756
DrugBr2BAPTA

ITPR1 ITPR3

4.26e-057332CID003081001
Drug[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate

ITPR1 ITPR3

4.26e-057332CID009547999
Drugts M

ZMPSTE24 ITPR1 ITPR3

4.59e-0548333CID000428025
Drug9 mM of H

ITPR1 ITPR3

5.67e-058332CID000130464
Drugbasic copper carbonate

ITPR1 ITPR3

5.67e-058332CID000025503
DrugNs 004

ITPR1 ITPR3

5.67e-058332CID000162750
DrugF2 g

ITPR1 ITPR3

5.67e-058332CID006857713
Drugclausenamide

ITPR1 ITPR3

9.10e-0510332CID000128412
DrugR 478

ITPR1 ITPR3

1.11e-0411332CID000084223
Drug8-amino-cADPR

ITPR1 ITPR3

1.11e-0411332CID003081323
Drugstrontium

EPX ITPR1 ITPR3

1.30e-0468333CID000104798
Drugretinoic acid; Up 200; 1uM; MCF7; HT_HG-U133A

C5AR2 TMPRSS2 DHRS2 ITPR1

1.44e-041853346971_UP
DrugAC1NRA23

TPSD1 TMPRSS2 ZMPSTE24

1.61e-0473333CID005287657
DrugTrazodone hydrochloride [25332-39-2]; Up 200; 9.8uM; MCF7; HT_HG-U133A

C5AR2 SLC6A9 CPT1A EPX

1.76e-041953347452_UP
DrugProcyclidine hydrochloride [1508-76-5]; Down 200; 12.4uM; HL60; HT_HG-U133A

GPR135 GPRC5C PRSS12 ITPR3

1.79e-041963342991_DN
DrugPropofol [2078-54-8]; Up 200; 22.4uM; HL60; HT_HG-U133A

SLC6A9 CPT1A EPX PRSS12

1.83e-041973343048_UP
DrugEstropipate [7280-37-7]; Up 200; 9.2uM; HL60; HT_HG-U133A

C5AR2 FGB SLC6A9 TMPRSS2

1.86e-041983342506_UP
DrugCinoxacin [28657-80-9]; Down 200; 15.2uM; MCF7; HT_HG-U133A

C5AR2 TMPRSS2 DHRS2 LRFN3

1.90e-041993343463_DN
DrugDapsone [80-08-0]; Up 200; 16.2uM; PC3; HT_HG-U133A

SLC6A1 C5AR2 FGB TMPRSS2

1.90e-041993345078_UP
Drugvalproate

SLC6A1 FGB SCO1 ITPR1 ITPR3

2.06e-04381335CID000003121
Drug11-trans-leukotriene E4

TPSD1 DHRS2 EPX

2.11e-0480333CID000003909
DrugAC1L8KRN

ITPR1 ITPR3

2.11e-0415332CID000403109
DrugGvapspat amide

ITPR1 ITPR3

2.11e-0415332CID000125015
Drugerucyl-CoA

CPT1A FMN1

2.11e-0415332CID006443765
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

ITPR1 ITPR3

7.00e-0512312DOID:1441 (implicated_via_orthology)
Diseaseobesity (implicated_via_orthology)

PRLHR MED13L ITPR1 ITPR3

7.39e-05215314DOID:9970 (implicated_via_orthology)
DiseaseNeurodevelopmental Disorders

SLC6A1 MED13L ITPR1

1.28e-0493313C1535926
DiseaseHyalinosis, Segmental Glomerular

ZMPSTE24 CRB2

3.97e-0428312C0086432
DiseaseFocal glomerulosclerosis

ZMPSTE24 CRB2

6.58e-0436312C0017668
Diseaseretinal vasculature measurement

SLC6A9 MED13L CRB2 ITPR1

2.01e-03517314EFO_0010554

Protein segments in the cluster

PeptideGeneStartEntry
GDRVPWARCRQAYFG

CPT1A

386

P50416
DGGAWVLGYRAGPAC

FMN1

646

Q68DA7
DPCRGGAGHWNGLYR

ITPR3

291

Q14573
PDGAGRPWCFYGDAR

PRSS12

141

P56730
KWRRYNFGGHGDCGP

MED13L

31

Q71F56
PCRGGAGYWNSLFRF

ITPR1

291

Q14643
GLGSFRCLCWPGYSG

CRB2

241

Q5IJ48
AAPCWTGAGRGRYLP

GPC2

426

Q8N158
RCHAANPNGRYYWGG

FGB

436

P02675
HGLPGYNAWRRFCGL

EPX

566

P11678
FALGCGGAARWYPRA

HMX1

106

Q9NP08
YLARYPHGGCRGWDD

MEGF8

981

Q7Z7M0
GAARAGPGLSYCVWV

MEGF8

1291

Q7Z7M0
ACASPPALGGRYFWA

LRFN3

271

Q9BTN0
GFSPCIFWGRGLFSA

MOGAT3

261

Q86VF5
LGAFLGAWPALCGRY

GPRC5C

221

Q9NQ84
AAGPWRGFCAASRFF

GPR135

176

Q8IZ08
RGGHWPYGAVGCRAL

C5AR2

96

Q9P296
GGIPYLWRLSGRFCG

ZMPSTE24

96

O75844
ARGYQGWFHPCARLS

DHRS2

6

Q13268
AWRASGRPGYCLGTR

SCO1

51

O75880
VCAGPGGFSEYVLWR

CMTR1

276

Q8N1G2
GFFRAIDCPYWSGAP

REXO1

6

Q8N1G1
LGFCVGLGNVWRFPY

SLC6A19

46

Q695T7
RVRGPYWMHFCGGSL

TPSD1

56

Q9BZJ3
AIGLGNVWRFPYLCG

SLC6A1

61

P30531
AFEPRGWVFGGGLCH

PRLHR

121

P49683
GGLPYCHQAWLDFRR

PLEKHG4

321

Q58EX7
ADGPRGCRFAGQWFP

CHRD

866

Q9H2X0
WGSGCAKAYRPGVYG

TMPRSS2

461

O15393
YCLQSRLWGRAGGPA

PLPPR3

96

Q6T4P5
GNVWRFPYLCYRNGG

SLC6A9

121

P48067
CAWGCRGSFIPARYN

SKOR2

151

Q2VWA4
AGCYGYARRLGGAWA

LRFN4

591

Q6PJG9