Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	organelle fission	MAP9 BRCA2 PRICKLE1 LRRK2 NUMA1 TERB1 APC KIF4B TOP6BL INO80 PIBF1 CCNB1 RAD50	2.82e-07	571	80	13	GO:0048285
GeneOntologyBiologicalProcess	nuclear division	MAP9 BRCA2 PRICKLE1 NUMA1 TERB1 APC KIF4B TOP6BL INO80 PIBF1 CCNB1 RAD50	6.26e-07	512	80	12	GO:0000280
GeneOntologyBiologicalProcess	nuclear chromosome segregation	MAP9 BRCA2 PRICKLE1 NUMA1 TERB1 APC KIF4B INO80 PIBF1 CCNB1	1.17e-06	356	80	10	GO:0098813
GeneOntologyBiologicalProcess	mitotic sister chromatid segregation	MAP9 PRICKLE1 NUMA1 APC KIF4B INO80 PIBF1 CCNB1	1.68e-06	212	80	8	GO:0000070
GeneOntologyBiologicalProcess	microtubule-based process	MAP9 RSPH14 BRCA2 PRICKLE1 DNAH17 STAU2 NUMA1 APC ROCK1 KIF4B ODAD4 INO80 ARHGEF2 PIBF1 CCDC38 CCNB1	2.49e-06	1058	80	16	GO:0007017
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization	MAP9 BRCA2 PRICKLE1 DNAH17 NUMA1 APC ROCK1 KIF4B ODAD4 INO80 ARHGEF2 PIBF1 CCNB1	3.74e-06	720	80	13	GO:0000226
GeneOntologyBiologicalProcess	sister chromatid segregation	MAP9 PRICKLE1 NUMA1 APC KIF4B INO80 PIBF1 CCNB1	6.39e-06	254	80	8	GO:0000819
GeneOntologyBiologicalProcess	establishment of chromosome localization	BRCA2 NUMA1 TERB1 APC PIBF1 CCNB1	7.95e-06	122	80	6	GO:0051303
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization involved in mitosis	MAP9 PRICKLE1 NUMA1 KIF4B ARHGEF2 PIBF1 CCNB1	8.18e-06	187	80	7	GO:1902850
GeneOntologyBiologicalProcess	chromosome localization	BRCA2 NUMA1 TERB1 APC PIBF1 CCNB1	1.15e-05	130	80	6	GO:0050000
GeneOntologyBiologicalProcess	chromosome segregation	MAP9 BRCA2 PRICKLE1 NUMA1 TERB1 APC KIF4B INO80 PIBF1 CCNB1	1.24e-05	465	80	10	GO:0007059
GeneOntologyBiologicalProcess	chromosome organization	MAP9 GNL3L BRCA2 PRICKLE1 NUMA1 TERB1 APC KIF4B INO80 PIBF1 CCNB1 RAD50	1.26e-05	686	80	12	GO:0051276
GeneOntologyBiologicalProcess	mitotic cell cycle process	MAP9 BRCA2 PRICKLE1 NUMA1 APC GIGYF2 ROCK1 KIF4B INO80 ARHGEF2 PIBF1 CCNB1 RAD50	2.32e-05	854	80	13	GO:1903047
GeneOntologyBiologicalProcess	spindle organization	MAP9 PRICKLE1 NUMA1 KIF4B INO80 PIBF1 CCNB1	2.63e-05	224	80	7	GO:0007051
GeneOntologyBiologicalProcess	mitotic spindle organization	MAP9 PRICKLE1 NUMA1 KIF4B PIBF1 CCNB1	2.68e-05	151	80	6	GO:0007052
GeneOntologyBiologicalProcess	spindle assembly	MAP9 PRICKLE1 NUMA1 KIF4B INO80 PIBF1	2.89e-05	153	80	6	GO:0051225
GeneOntologyBiologicalProcess	mitotic nuclear division	MAP9 PRICKLE1 NUMA1 APC KIF4B INO80 PIBF1 CCNB1	3.09e-05	316	80	8	GO:0140014
GeneOntologyBiologicalProcess	metaphase chromosome alignment	BRCA2 NUMA1 APC PIBF1 CCNB1	6.04e-05	107	80	5	GO:0051310
GeneOntologyBiologicalProcess	regionalization	EOMES BPTF AHI1 PRICKLE1 HIPK1 APC ODAD4 ZEB2 PALB2	9.65e-05	478	80	9	GO:0003002
GeneOntologyBiologicalProcess	cell cycle process	MAP9 BRCA2 PRICKLE1 NUMA1 TERB1 APC SEPTIN11 GIGYF2 ROCK1 KIF4B TOP6BL INO80 ARHGEF2 PIBF1 CCNB1 RAD50	1.12e-04	1441	80	16	GO:0022402
GeneOntologyBiologicalProcess	mitotic cell cycle	MAP9 BRCA2 PRICKLE1 NUMA1 APC GIGYF2 ROCK1 KIF4B INO80 ARHGEF2 PIBF1 CCNB1 RAD50	1.34e-04	1014	80	13	GO:0000278
GeneOntologyBiologicalProcess	cytoskeleton-dependent cytokinesis	MAP9 APC SEPTIN11 ROCK1 KIF4B	1.36e-04	127	80	5	GO:0061640
GeneOntologyBiologicalProcess	cytokinesis	MAP9 BRCA2 APC SEPTIN11 ROCK1 KIF4B	1.42e-04	204	80	6	GO:0000910
GeneOntologyBiologicalProcess	negative regulation of protein modification process	GNL3L LRRK2 APC NCOA7 ROCK1 INPP5F PIBF1 PPP4R4 CCNB1	1.62e-04	512	80	9	GO:0031400
GeneOntologyBiologicalProcess	pattern specification process	EOMES BPTF AHI1 PRICKLE1 HIPK1 APC ODAD4 ZEB2 PALB2	1.98e-04	526	80	9	GO:0007389
GeneOntologyBiologicalProcess	establishment of organelle localization	AHI1 BRCA2 LRRK2 NUMA1 TERB1 APC ARHGEF2 PIBF1 CCNB1	2.61e-04	546	80	9	GO:0051656
GeneOntologyBiologicalProcess	cell division	MAP9 BRCA2 NUMA1 APC SEPTIN11 ROCK1 KIF4B INO80 ARHGEF2 CCNB1	3.55e-04	697	80	10	GO:0051301
GeneOntologyBiologicalProcess	anterior/posterior pattern specification	BPTF PRICKLE1 HIPK1 APC ZEB2 PALB2	3.98e-04	247	80	6	GO:0009952
GeneOntologyBiologicalProcess	mitotic spindle assembly	MAP9 PRICKLE1 KIF4B PIBF1	4.52e-04	92	80	4	GO:0090307
GeneOntologyBiologicalProcess	protein localization to microtubule organizing center	NUMA1 APC PIBF1	4.64e-04	39	80	3	GO:1905508
GeneOntologyBiologicalProcess	mitotic cytokinesis	MAP9 APC ROCK1 KIF4B	5.11e-04	95	80	4	GO:0000281
GeneOntologyBiologicalProcess	DNA recombination	BRCA2 TBX21 TERB1 TOP6BL INO80 PALB2 RAD50	5.65e-04	368	80	7	GO:0006310
GeneOntologyBiologicalProcess	regulation of chromosome organization	GNL3L NUMA1 APC INO80 CCNB1 RAD50	5.88e-04	266	80	6	GO:0033044
GeneOntologyBiologicalProcess	regulation of microtubule cytoskeleton organization	MAP9 NUMA1 APC ROCK1 ARHGEF2	6.13e-04	176	80	5	GO:0070507
HumanPheno	Prostate neoplasm	BRCA2 APC PALB2 RAD50	2.08e-05	28	31	4	HP:0100787
HumanPheno	Prostate cancer	BRCA2 APC PALB2 RAD50	2.08e-05	28	31	4	HP:0012125
HumanPheno	Breast carcinoma	PMS1 BRCA2 APC PALB2 RAD50	4.41e-05	67	31	5	HP:0003002
HumanPheno	Abnormal prostate morphology	BRCA2 APC PALB2 RAD50	5.77e-05	36	31	4	HP:0008775
HumanPheno	Tumours of the breast	PMS1 BRCA2 APC PALB2 RAD50	6.69e-05	73	31	5	HP:0010623
HumanPheno	Primary peritoneal carcinoma	BRCA2 PALB2 RAD50	7.10e-05	14	31	3	HP:0030406
HumanPheno	Colon cancer	PMS1 BRCA2 APC PALB2	7.96e-05	39	31	4	HP:0003003
HumanPheno	Neoplasm of the pancreas	PMS1 BRCA2 APC PALB2 RAD50	1.55e-04	87	31	5	HP:0002894
HumanPheno	Medulloblastoma	BRCA2 APC PALB2	1.85e-04	19	31	3	HP:0002885
HumanPheno	Neoplasm of the breast	PMS1 BRCA2 APC PALB2 RAD50	2.02e-04	92	31	5	HP:0100013
MousePheno	absent distal visceral endoderm	BPTF INO80	2.26e-05	2	67	2	MP:0012161
Domain	EIF3C_N_dom	EIF3C EIF3CL	1.81e-05	2	80	2	IPR008905
Domain	eIF-3c_N	EIF3C EIF3CL	1.81e-05	2	80	2	PF05470
Domain	EIF3C	EIF3C EIF3CL	1.81e-05	2	80	2	IPR027516
Domain	TF_T-box	EOMES TBX21 MGA	4.93e-05	17	80	3	IPR001699
Domain	TBOX	EOMES TBX21 MGA	4.93e-05	17	80	3	SM00425
Domain	TF_T-box_CS	EOMES TBX21 MGA	4.93e-05	17	80	3	IPR018186
Domain	-	EOMES TBX21 MGA	4.93e-05	17	80	3	2.60.40.820
Domain	TBOX_3	EOMES TBX21 MGA	4.93e-05	17	80	3	PS50252
Domain	T-box	EOMES TBX21 MGA	4.93e-05	17	80	3	PF00907
Domain	TBOX_1	EOMES TBX21 MGA	4.93e-05	17	80	3	PS01283
Domain	TBOX_2	EOMES TBX21 MGA	4.93e-05	17	80	3	PS01264
Domain	p53-like_TF_DNA-bd	EOMES TBX21 MGA	1.52e-03	53	80	3	IPR008967
Domain	PINT	EIF3C EIF3CL	2.09e-03	16	80	2	SM00088
Domain	PCI_dom	EIF3C EIF3CL	2.36e-03	17	80	2	IPR000717
Domain	PCI	EIF3C EIF3CL	2.36e-03	17	80	2	PF01399
Domain	-	RSPH14 LRRK2 TERB1 APC PPP4R4	2.65e-03	222	80	5	1.25.10.10
Domain	tRNA-bd_arm	RPRD2 PIBF1	4.70e-03	24	80	2	IPR010978
Domain	ARM-like	RSPH14 LRRK2 TERB1 APC PPP4R4	6.06e-03	270	80	5	IPR011989
Domain	Arm	RSPH14 APC	7.77e-03	31	80	2	PF00514
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	CASP8AP2 BRCA2 APC GIGYF2 ICE1 INPP5F MGA OBI1 ZEB2 PALB2 RAD50	6.38e-09	418	85	11	34709266
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	TUT4 GNL3L THYN1 TMTC3 APC ZNF638 ROCK1 RPRD2 ICE1 ARHGEF2 R3HDM1 MGA	2.27e-07	733	85	12	34672954
Pubmed	Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells.	EOMES TBX21 ZEB2	2.80e-07	6	85	3	31393266
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	PMS1 GNL3L SH3D19 TLN1 STAU2 NUMA1 ZNF638 GIGYF2 NCOA7 RPRD2 ICE1 EIF3C RAD50	4.31e-07	934	85	13	33916271
Pubmed	Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals.	BRCA2 PALB2 RAD50	4.90e-07	7	85	3	21356067
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	PMS1 BPTF BRCA2 STAU2 NUMA1 ZNF638 GIGYF2 RPRD2 ICE1 UQCRC2 FAM98B MGA DEK	5.47e-07	954	85	13	36373674
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	TUT4 TLN1 STAU2 APC SEPTIN11 GIGYF2 UQCRC2 INO80 R3HDM1 MGA CCNB1	1.56e-06	724	85	11	36232890
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	BPTF NUMA1 ZNF638 GIGYF2 EIF3C ARHGEF2 RFX7 PRG4 PALB2 EIF3CL RAD50	2.95e-06	774	85	11	15302935
Pubmed	A human MAP kinase interactome.	CASP8AP2 HIPK1 SH3D19 APC GIGYF2 PIBF1 MBD5 MGA OBI1	3.04e-06	486	85	9	20936779
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SH3D19 NUMA1 APC SEPTIN11 GIGYF2 ROCK1 KIF4B CNKSR2 ARHGEF2 MGA ZEB2 RAD50	3.90e-06	963	85	12	28671696
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	STAU2 NUMA1 APC ZNF638 RPRD2 EIF3C ARHGEF2 OBI1 EIF3CL	4.01e-06	503	85	9	16964243
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	BPTF NUMA1 ZNF638 RPRD2 EIF3C EIF3CL RAD50	4.74e-06	271	85	7	32433965
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	EOMES BPTF GNL3L NUMA1 ICE1 MGA	5.00e-06	177	85	6	26206133
Pubmed	Inflammation programs self-reactive CD8+ T cells to acquire T-box-mediated effector function but does not prevent deletional tolerance.	EOMES TBX21	5.90e-06	2	85	2	24823810
Pubmed	Differential transcription of Eomes and T-bet during maturation of mouse uterine natural killer cells.	EOMES TBX21	5.90e-06	2	85	2	16204645
Pubmed	Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin.	EOMES TBX21	5.90e-06	2	85	2	16273099
Pubmed	T-BET and EOMES Accelerate and Enhance Functional Differentiation of Human Natural Killer Cells.	EOMES TBX21	5.90e-06	2	85	2	34630413
Pubmed	Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche.	EOMES TBX21	5.90e-06	2	85	2	20935204
Pubmed	Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.	BRCA2 PALB2	5.90e-06	2	85	2	17200672
Pubmed	Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection.	EOMES TBX21	5.90e-06	2	85	2	23197535
Pubmed	Eomes+T-betlow CD8+ T Cells Are Functionally Impaired and Are Associated with Poor Clinical Outcome in Patients with Acute Myeloid Leukemia.	EOMES TBX21	5.90e-06	2	85	2	30709927
Pubmed	Rare germline variants in PALB2 and BRCA2 in familial and sporadic chordoma.	BRCA2 PALB2	5.90e-06	2	85	2	35762214
Pubmed	EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.	EIF3C EIF3CL	5.90e-06	2	85	2	36157221
Pubmed	IL-12 Influence mTOR to Modulate CD8+ T Cells Differentiation through T-bet and Eomesodermin in Response to Invasive Pulmonary Aspergillosis.	EOMES TBX21	5.90e-06	2	85	2	28924369
Pubmed	The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection.	TBX21 ZEB2	5.90e-06	2	85	2	26503446
Pubmed	Breast-cancer risk in families with mutations in PALB2.	BRCA2 PALB2	5.90e-06	2	85	2	25099575
Pubmed	Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains.	BRCA2 PALB2	5.90e-06	2	85	2	22194698
Pubmed	Fanconi anemia gene mutations are not involved in sporadic Wilms tumor.	BRCA2 PALB2	5.90e-06	2	85	2	20589654
Pubmed	Characterization of eomesodermin and T-bet expression by allostimulated CD8+ T cells of healthy volunteers and kidney transplant patients in relation to graft outcome.	EOMES TBX21	5.90e-06	2	85	2	30246373
Pubmed	The low EOMES/TBX21 molecular phenotype in multiple sclerosis reflects CD56+ cell dysregulation and is affected by immunomodulatory therapies.	EOMES TBX21	5.90e-06	2	85	2	26762769
Pubmed	Analysis of PALB2/FANCN-associated breast cancer families.	BRCA2 PALB2	5.90e-06	2	85	2	17420451
Pubmed	The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease.	EOMES TBX21	5.90e-06	2	85	2	24495857
Pubmed	Structural basis for recruitment of BRCA2 by PALB2.	BRCA2 PALB2	5.90e-06	2	85	2	19609323
Pubmed	Mutations in BRCA2 and PALB2 in male breast cancer cases from the United States.	BRCA2 PALB2	5.90e-06	2	85	2	20927582
Pubmed	Eomes is sufficient to regulate IL-10 expression and cytotoxic effector molecules in murine CD4+ T cells.	EOMES TBX21	5.90e-06	2	85	2	36756120
Pubmed	T-bet and Eomes govern differentiation and function of mouse and human NK cells and ILC1.	EOMES TBX21	5.90e-06	2	85	2	29424438
Pubmed	Epigenetic and transcriptional programs lead to default IFN-gamma production by gammadelta T cells.	EOMES TBX21	5.90e-06	2	85	2	17312115
Pubmed	Control of effector CD8+ T cell function by the transcription factor Eomesodermin.	EOMES TBX21	5.90e-06	2	85	2	14605368
Pubmed	PALB2 regulates recombinational repair through chromatin association and oligomerization.	BRCA2 PALB2	5.90e-06	2	85	2	19423707
Pubmed	Genotype-cancer association in patients with Fanconi anemia due to pathogenic variants in FANCD1 (BRCA2) or FANCN (PALB2).	BRCA2 PALB2	5.90e-06	2	85	2	34687993
Pubmed	Mammary tumor induction and premature ovarian failure in ApcMin mice are not enhanced by Brca2 deficiency.	BRCA2 APC	5.90e-06	2	85	2	11215675
Pubmed	Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells.	EOMES TBX21	5.90e-06	2	85	2	32991634
Pubmed	NK Cell Functional Impairment after Allogeneic Hematopoietic Stem Cell Transplantation Is Associated with Reduced Levels of T-bet and Eomesodermin.	EOMES TBX21	5.90e-06	2	85	2	26438526
Pubmed	Differential localization of T-bet and Eomes in CD8 T cell memory populations.	EOMES TBX21	5.90e-06	2	85	2	23455505
Pubmed	A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance.	BRCA2 PALB2	5.90e-06	2	85	2	21637299
Pubmed	T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection.	EOMES TBX21	5.90e-06	2	85	2	25032686
Pubmed	Two Missense Variants Detected in Breast Cancer Probands Preventing BRCA2-PALB2 Protein Interaction.	BRCA2 PALB2	5.90e-06	2	85	2	30410870
Pubmed	Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors.	EOMES TBX21	5.90e-06	2	85	2	22490682
Pubmed	T-BET and EOMES sustain mature human NK cell identity and antitumor function.	EOMES TBX21	5.90e-06	2	85	2	37279078
Pubmed	Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample.	BRCA2 PALB2	5.90e-06	2	85	2	20872766
Pubmed	Cooperation between engulfment receptors: the case of ABCA1 and MEGF10.	ABCA1 MEGF10	5.90e-06	2	85	2	17205124
Pubmed	Bona Fide Th17 Cells without Th1 Functional Plasticity Protect against Influenza.	EOMES TBX21	5.90e-06	2	85	2	35338093
Pubmed	INO80 haploinsufficiency inhibits colon cancer tumorigenesis via replication stress-induced apoptosis.	APC INO80	5.90e-06	2	85	2	29383140
Pubmed	Eomesodermin and T-bet mark developmentally distinct human natural killer cells.	EOMES TBX21	5.90e-06	2	85	2	28289707
Pubmed	The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation.	EOMES TBX21	5.90e-06	2	85	2	22261438
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	GIGYF2 RPRD2 PIBF1 MGA ZEB2 CCNB1	6.25e-06	184	85	6	32908313
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	BPTF TLN1 NUMA1 ZNF638 GIGYF2 EIF3C UQCRC2 EEA1 ARHGEF2 MGA DEK RAD50	7.26e-06	1024	85	12	24711643
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	GNL3L ARHGEF2 MGA DEK ZEB2	7.41e-06	109	85	5	33554859
Pubmed	Identification of cAMP analogue inducible genes in RAW264 macrophages.	ABCA1 LRRK2 INPP5F	7.71e-06	16	85	3	11004510
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SH3D19 APC GIGYF2 NCOA7 INPP5F ARHGEF2 R3HDM1 PIBF1 RFX7 OBI1 PPP4R4	8.09e-06	861	85	11	36931259
Pubmed	Human transcription factor protein interaction networks.	BPTF STAU2 NUMA1 ZNF638 GIGYF2 RPRD2 EIF3C UQCRC2 INO80 R3HDM1 RFX7 MGA ZEB2 RAD50	9.08e-06	1429	85	14	35140242
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CYLC1 BPTF MAP9 PDE6A NUMA1 CC2D1B UQCRC2 FAM98B EEA1 ARHGEF2 OBI1 ZEB2 PALB2 PPP4R4	1.01e-05	1442	85	14	35575683
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	GTF2H1 BRCA2 RPRD2 ICE1 FAM98B MGA PALB2 RAD50	1.56e-05	453	85	8	29656893
Pubmed	RAD50 germline mutations are associated with poor survival in BRCA1/2-negative breast cancer patients.	BRCA2 RAD50	1.77e-05	3	85	2	29726012
Pubmed	Two PALB2 germline mutations found in both BRCA1+ and BRCAx familial breast cancer.	BRCA2 PALB2	1.77e-05	3	85	2	25833210
Pubmed	[Role of transcription factor T-bet and Eomes in IFN-gamma secretion of different human T cell subsets].	EOMES TBX21	1.77e-05	3	85	2	20056084
Pubmed	A Survey of BRCA1, BRCA2, and PALB2 mutations in women with breast cancer in Trinidad and Tobago.	BRCA2 PALB2	1.77e-05	3	85	2	27469594
Pubmed	T-bet and eomesodermin play critical roles in directing T cell differentiation to Th1 versus Th17.	EOMES TBX21	1.77e-05	3	85	2	19050290
Pubmed	Zeb2 regulates differentiation of long-lived effector of invariant natural killer T cells.	TBX21 ZEB2	1.77e-05	3	85	2	37903859
Pubmed	The risk of breast cancer due to PALB2 gene mutations.	BRCA2 PALB2	1.77e-05	3	85	2	28791855
Pubmed	Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors.	BRCA2 PALB2	1.77e-05	3	85	2	33186520
Pubmed	Germline mutations of multiple breast cancer-related genes are differentially associated with triple-negative breast cancers and prognostic factors.	BRCA2 PALB2	1.77e-05	3	85	2	32029870
Pubmed	Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks.	BRCA2 PALB2	1.77e-05	3	85	2	24485656
Pubmed	A Phase I/II Study of Veliparib (ABT-888) in Combination with 5-Fluorouracil and Oxaliplatin in Patients with Metastatic Pancreatic Cancer.	BRCA2 PALB2	1.77e-05	3	85	2	32669374
Pubmed	Identification and Management of Pathogenic Variants in BRCA1, BRCA2, and PALB2 in a Tumor-Only Genomic Testing Program.	BRCA2 PALB2	1.77e-05	3	85	2	35363308
Pubmed	Cutting Edge: Divergent Requirement of T-Box Transcription Factors in Effector and Memory NK Cells.	EOMES TBX21	1.77e-05	3	85	2	29440505
Pubmed	A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development.	BRCA2 PALB2	1.77e-05	3	85	2	26990772
Pubmed	Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.	BRCA2 PALB2	1.77e-05	3	85	2	16793542
Pubmed	Contribution of germline mutations in the BRCA and PALB2 genes to pancreatic cancer in Italy.	BRCA2 PALB2	1.77e-05	3	85	2	21989927
Pubmed	The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin.	EOMES TBX21	1.77e-05	3	85	2	20060330
Pubmed	Analysis of large deletions in BRCA1, BRCA2 and PALB2 genes in Finnish breast and ovarian cancer families.	BRCA2 PALB2	1.77e-05	3	85	2	18501021
Pubmed	The frequency of founder mutations in the BRCA1, BRCA2, and APC genes in Australian Ashkenazi Jews: implications for the generality of U.S. population data.	BRCA2 APC	1.77e-05	3	85	2	11466700
Pubmed	BRCA and pancreatic cancer.	BRCA2 PALB2	1.77e-05	3	85	2	23846919
Pubmed	Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2.	BRCA2 PALB2	1.77e-05	3	85	2	27490902
Pubmed	Multiple gene sequencing for risk assessment in patients with early-onset or familial breast cancer.	BRCA2 RAD50	1.77e-05	3	85	2	26824983
Pubmed	Optimization of prediction methods for risk assessment of pathogenic germline variants in the Japanese population.	BRCA2 PALB2	1.77e-05	3	85	2	34036661
Pubmed	T-bet and eomesodermin are required for T cell-mediated antitumor immune responses.	EOMES TBX21	1.77e-05	3	85	2	20713880
Pubmed	Mutation of the predicted p34cdc2 phosphorylation sites in NuMA impair the assembly of the mitotic spindle and block mitosis.	NUMA1 CCNB1	1.77e-05	3	85	2	7769006
Pubmed	Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis.	EOMES TBX21	1.77e-05	3	85	2	12128215
Pubmed	IRF4 Regulates the Ratio of T-Bet to Eomesodermin in CD8+ T Cells Responding to Persistent LCMV Infection.	EOMES TBX21	1.77e-05	3	85	2	26714260
Pubmed	Multigene Panel Testing Detects Equal Rates of Pathogenic BRCA1/2 Mutations and has a Higher Diagnostic Yield Compared to Limited BRCA1/2 Analysis Alone in Patients at Risk for Hereditary Breast Cancer.	BRCA2 PALB2	1.77e-05	3	85	2	26219241
Pubmed	Active STAT5 regulates T-bet and eomesodermin expression in CD8 T cells and imprints a T-bet-dependent Tc1 program with repressed IL-6/TGF-β1 signaling.	EOMES TBX21	1.77e-05	3	85	2	24006458
Pubmed	BRCA and PALB2 mutations in a cohort of male breast cancer with one bilateral case.	BRCA2 PALB2	1.77e-05	3	85	2	32058061
Pubmed	Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination.	BRCA2 PALB2	1.77e-05	3	85	2	20871615
Pubmed	Mutations in BRCA1, BRCA2, and PALB2, and a panel of 50 cancer-associated genes in pancreatic ductal adenocarcinoma.	BRCA2 PALB2	1.77e-05	3	85	2	29802286
Pubmed	PALB2 links BRCA1 and BRCA2 in the DNA-damage response.	BRCA2 PALB2	1.77e-05	3	85	2	19268590
Pubmed	Compensatory functions and interdependency of the DNA-binding domain of BRCA2 with the BRCA1-PALB2-BRCA2 complex.	BRCA2 PALB2	1.77e-05	3	85	2	24285729
Pubmed	Founder BRCA1/BRCA2/PALB2 pathogenic variants in French-Canadian breast cancer cases and controls.	BRCA2 PALB2	1.77e-05	3	85	2	32300229
Pubmed	Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells.	EOMES TBX21	1.77e-05	3	85	2	34521844
Pubmed	T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model.	EOMES TBX21	1.77e-05	3	85	2	28550044
Interaction	PHF21A interactions	CASP8AP2 BRCA2 APC GIGYF2 ICE1 INPP5F MGA OBI1 ZEB2 RAD50	1.81e-06	343	85	10	int:PHF21A
Interaction	RCOR1 interactions	CASP8AP2 BRCA2 NUMA1 APC GIGYF2 ICE1 MGA OBI1 ZEB2 PALB2 RAD50	7.14e-06	494	85	11	int:RCOR1
Interaction	TOP6BL interactions	BRCA2 TOP6BL	1.76e-05	2	85	2	int:TOP6BL
Interaction	H2BC9 interactions	SECISBP2L CYLC1 CASP8AP2 BPTF NUMA1 GIGYF2 CC2D1B KIF4B MBD5 DEK	1.81e-05	446	85	10	int:H2BC9
Interaction	BRCA2 interactions	PMS1 BRCA2 LRRK2 RPRD2 TOP6BL PRG4 PALB2 CCNB1 RAD50	3.46e-05	384	85	9	int:BRCA2
Interaction	HDAC1 interactions	CASP8AP2 BPTF BRCA2 TLN1 APC ZNF638 GIGYF2 EIF3C INPP5F MGA OBI1 ZEB2 PALB2 CCNB1 RAD50	5.52e-05	1108	85	15	int:HDAC1
Interaction	SMC5 interactions	PMS1 BPTF BRCA2 STAU2 NUMA1 ZNF638 GIGYF2 RPRD2 ICE1 UQCRC2 FAM98B MGA DEK RAD50	7.07e-05	1000	85	14	int:SMC5
Interaction	H2BC5 interactions	SECISBP2L CYLC1 CHIA TLN1 NUMA1 CC2D1B EIF3C EEA1	7.81e-05	331	85	8	int:H2BC5
Interaction	BMI1 interactions	STAU2 NUMA1 ZNF638 GIGYF2 EIF3C FAM98B EEA1 ARHGEF2 MGA DEK EIF3CL	9.97e-05	659	85	11	int:BMI1
GeneFamily	T-boxes	EOMES TBX21 MGA	1.58e-05	18	50	3	766
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	BRCA2 PALB2	1.38e-03	20	50	2	548
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	SECISBP2L PMS1 BPTF TUT4 BRCA2 STAU2 APC ZNF638 GIGYF2 ROCK1 INPP5F R3HDM1 PIBF1 SUCO DEK ZEB2	8.11e-09	856	82	16	M4500
Coexpression	HAMAI_APOPTOSIS_VIA_TRAIL_UP	CASP8AP2 BPTF AHI1 TUT4 APC ZNF638 EEA1 PIBF1 SUCO DEK ZNF354B OBI1 RAD50	1.23e-07	656	82	13	M18979
Coexpression	BILANGES_SERUM_SENSITIVE_VIA_TSC2	NUMA1 EIF3C FAM98B EIF3CL	2.99e-06	32	82	4	MM1307
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	PMS1 BPTF TUT4 STAU2 ZNF638 GIGYF2 INPP5F R3HDM1 PIBF1	1.53e-05	466	82	9	M13522
Coexpression	GSE41867_DAY6_EFFECTOR_VS_DAY30_MEMORY_CD8_TCELL_LCMV_ARMSTRONG_DN	TLN1 DNAH17 LRRK2 APC RPRD2 INPP5F	3.96e-05	200	82	6	M9459
Coexpression	GSE28237_FOLLICULAR_VS_EARLY_GC_BCELL_UP	TUT4 NLRP10 DNAH17 APC ZNF638 MBD5	3.96e-05	200	82	6	M4884
Coexpression	GSE12845_IGD_POS_BLOOD_VS_PRE_GC_TONSIL_BCELL_DN	TUT4 BRCA2 SEPTIN11 ROCK1 RFX7 CCNB1	3.96e-05	200	82	6	M3188
Coexpression	DAZARD_RESPONSE_TO_UV_NHEK_DN	PMS1 BPTF TUT4 ZNF638 ICE1 SUCO CCNB1	4.38e-05	300	82	7	M8702
Coexpression	MCBRYAN_PUBERTAL_BREAST_5_6WK_DN	SECISBP2L EIF3C ARHGEF2 ZEB2 EIF3CL	7.16e-05	137	82	5	MM990
Coexpression	DAZARD_UV_RESPONSE_CLUSTER_G6	PMS1 TUT4 ZNF638 SUCO CCNB1	9.37e-05	145	82	5	M1810
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3	PMS1 CASP8AP2 BPTF AHI1 TUT4 GNL3L BRCA2 APC ROCK1 FAM98B R3HDM1 PIBF1 MBD5 CCDC38 DEK OBI1 PALB2 CCNB1 RAD50	2.80e-07	1257	83	19	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3	CASP8AP2 BRCA2 ZNF638 GIGYF2 ROCK1 EIF3C FAM98B PIBF1 RFX7 ZEB2 PALB2 CCNB1	1.04e-06	532	83	12	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500	PMS1 CASP8AP2 BPTF AHI1 TUT4 GNL3L BRCA2 APC ROCK1 FAM98B R3HDM1 PIBF1 MBD5 CCDC38 DEK OBI1 PALB2 CCNB1 RAD50	2.63e-06	1459	83	19	facebase_RNAseq_e10.5_Emin_LatNas_2500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000_k-means-cluster#2	CASP8AP2 AHI1 TUT4 BRCA2 ROCK1 FAM98B PIBF1 DEK RAD50	3.51e-06	311	83	9	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000_K2
CoexpressionAtlas	DevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_top-relative-expression-ranked_1000	CASP8AP2 FOXN2 AHI1 TUT4 APC ZNF638 GIGYF2 NCOA7 R3HDM1 KCNIP3 SUCO ZEB2 MEGF10	8.85e-06	772	83	13	gudmap_developingKidney_e15.5_Ureteral Smooth Musc_1000
CoexpressionAtlas	facebase_RNAseq_e10.5_MaxArch_2500_K3	CASP8AP2 TUT4 BRCA2 HIPK1 STAU2 APC ZNF638 ROCK1 CNKSR2 FAM98B R3HDM1 MBD5 KCNIP3 CCDC38 DEK RAD50	2.36e-05	1252	83	16	facebase_RNAseq_e10.5_MaxArch_2500_K3
CoexpressionAtlas	DevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_top-relative-expression-ranked_1000	GLYAT BPTF AHI1 TUT4 APC GIGYF2 NCOA7 INO80 PIBF1 MGA SUCO ZEB2	5.89e-05	795	83	12	gudmap_developingKidney_e15.5_anlage of loop of Henle_1000
CoexpressionAtlas	facebase_RNAseq_e10.5_MandArch_2500_K1	CASP8AP2 GTF2H1 AHI1 TUT4 BRCA2 APC ROCK1 CNKSR2 FAM98B R3HDM1 PIBF1 CCDC38 DEK PALB2 RAD50	8.30e-05	1241	83	15	facebase_RNAseq_e10.5_MandArch_2500_K1
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_2500_k-means-cluster#1	BRCA2 APC ZNF638 GIGYF2 ROCK1 EIF3C PIBF1 RFX7 DEK	8.96e-05	469	83	9	Facebase_RNAseq_e8.5_Floor Plate_2500_K1
CoexpressionAtlas	FacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_500_k-means-cluster#5	CASP8AP2 AHI1 BRCA2 ZNF638 ROCK1 PIBF1	8.99e-05	186	83	6	Facebase_RNAseq_e10.5_Mandibular Arch_500_K5
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500_k-means-cluster#3	CASP8AP2 BRCA2 ROCK1 FAM98B PIBF1 DEK	1.07e-04	192	83	6	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500_K3
CoexpressionAtlas	DevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_top-relative-expression-ranked_500	TUT4 GIGYF2 NCOA7 R3HDM1 KCNIP3 SUCO ZEB2 MEGF10	1.51e-04	393	83	8	gudmap_developingKidney_e15.5_Ureteral Smooth Musc_500
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_MedNas_2500_K1	CASP8AP2 AHI1 TUT4 BRCA2 NEXMIF APC FAM98B R3HDM1 KCNIP3 DEK OBI1 CCNB1 RAD50	2.27e-04	1060	83	13	facebase_RNAseq_e10.5_Emin_MedNas_2500_K1
CoexpressionAtlas	DevelopingKidney_e15.5_Cap mesenchyme_emap-27738_k-means-cluster#5_top-relative-expression-ranked_1000	AHI1 TUT4 APC NCOA7 INO80	2.71e-04	146	83	5	gudmap_developingKidney_e15.5_Cap mesenchyme_1000_k5
CoexpressionAtlas	FacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_1000_k-means-cluster#3	TUT4 BRCA2 STAU2 APC ROCK1 ARHGEF2 MGA RAD50	2.86e-04	432	83	8	Facebase_RNAseq_e10.5_Maxillary Arch_1000_K3
CoexpressionAtlas	DevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#5_top-relative-expression-ranked_1000	AHI1 TUT4 APC GIGYF2 INO80 R3HDM1 SUCO	3.65e-04	339	83	7	gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_1000_k5
CoexpressionAtlas	facebase_RNAseq_e10.5_MandArch_2500	CASP8AP2 GTF2H1 AHI1 TUT4 BRCA2 APC ROCK1 CNKSR2 FAM98B R3HDM1 PIBF1 CCDC38 DEK PALB2 RAD50	5.14e-04	1468	83	15	facebase_RNAseq_e10.5_MandArch_2500
CoexpressionAtlas	DevelopingGonad_P2_ovary_emap-30224_k-means-cluster#4_top-relative-expression-ranked_1000	CCDC73 NEXMIF TERB1 ROCK1 EEA1	5.16e-04	168	83	5	gudmap_developingGonad_P2_ovary_1000_k4
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	BPTF TMTC3 SEPTIN11 ROCK1 EEA1 DEK RAD50	1.01e-07	199	84	7	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	HIPK1 NUMA1 GIGYF2 RPRD2 MBD5 MGA	7.38e-07	166	84	6	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	Severe-B_intermediate-10\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	TLN1 TBX21 LRRK2 EEA1 DEK ZEB2	1.11e-06	178	84	6	b7374a97c51239782bed658381a02cb1b3d9bf66
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TUT4 TLN1 APC ZNF638 SEPTIN11 ZEB2	1.35e-06	184	84	6	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	Brain_organoid-organoid_Kanton_Nature\|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.	CASP8AP2 BPTF SEPTIN11 ROCK1 ICE1 DEK	1.39e-06	185	84	6	857c7ca8493e91ef1d0078ddafd6082020f9b169
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PDE6A TLN1 LRRK2 C18orf63 ROCK1 ZEB2	1.43e-06	186	84	6	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	BPTF MAP9 FOXN2 GNL3L GIGYF2 MGA	1.77e-06	193	84	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	BPTF MAP9 LRRIQ1 ROCK1 ODAD4 RAD50	2.06e-06	198	84	6	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	(10)_Ciliated-(2)_GFP_FOXI1\|(10)_Ciliated / shred by cell type by condition	BPTF MAP9 LRRIQ1 ROCK1 EEA1 RAD50	2.12e-06	199	84	6	61b1ed2db71b96157b92b7535d1955a4033098da
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	BPTF LRRIQ1 TMTC3 ROCK1 EEA1 RAD50	2.12e-06	199	84	6	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EOMES TBX21 STAU2 PRG4 C3orf49	1.28e-05	159	84	5	95128a2367ff2a639b21913c0350924c174faef8
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	EOMES GLYAT TBX21 ITPRID1 PRG4	1.28e-05	159	84	5	a710551512aa0b7a281a81bea651a43c9f3b3539
ToppCell	Control-B_intermediate-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	TUT4 ICE1 EIF3C EIF3CL RAD50	1.62e-05	167	84	5	948504367ecf58144d9dd74d2ec531358fc4b309
ToppCell	10x5'-Lung-Lymphocytic_T_CD4/8-lo-Trm_Tgd\|Lung / Manually curated celltypes from each tissue	GTF2H1 SH3D19 STAU2 CC2D1B ZNF354B	1.62e-05	167	84	5	dcbcc658082910838c8082d71a64917055086cc4
ToppCell	droplet-Marrow-nan-3m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SECISBP2L GIGYF2 EEA1 R3HDM1 ZEB2	1.71e-05	169	84	5	5f5bec13208f4c3b6eacbba180c8a6402743b76e
ToppCell	COVID-19_Mild-NK_activated\|COVID-19_Mild / Disease condition and Cell class	EOMES TUT4 ICE1 EIF3C EIF3CL	2.51e-05	183	84	5	22bd05135906d0ecc4ba8c2e0a666093d1bf3b8f
ToppCell	Mild/Remission-B_intermediate-10\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	TLN1 TBX21 LRRK2 EEA1 ZEB2	2.51e-05	183	84	5	278064c9f0582463b83bf156d34e77f60187613b
ToppCell	Control-Neu_4\|World / 5 Neutrophil clusters in COVID-19 patients	CASP8AP2 HIPK1 EIF3C MGA RAD50	2.57e-05	184	84	5	ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRRIQ1 PRICKLE1 CNKSR2 R3HDM1 KCNIP3	2.71e-05	186	84	5	84ba666237c18189d7e7556bd92dd953af733c00
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	CASP8AP2 GNL3L APC GIGYF2 RBM41	2.71e-05	186	84	5	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D175\|Adult / Lineage, Cell type, age group and donor	GABRB2 LRRK2 NCOA7 INO80 PPP4R4	2.85e-05	188	84	5	ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	MAP9 AHI1 TUT4 HIPK1 ODAD4	3.08e-05	191	84	5	1ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCell	Control-B_intermediate-10\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	TLN1 TBX21 EEA1 INPP5F ZEB2	3.16e-05	192	84	5	224bd958369ba8fa0d7be2126f7dc61c9f6ac19d
ToppCell	moderate-Epithelial-FOXN4+\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MAP9 AHI1 LRRIQ1 BRCA2 CCNB1	3.32e-05	194	84	5	5dffa578149104dda33774361e9e77b227b5f1ce
ToppCell	CV-Moderate-6\|CV / Virus stimulation, Condition and Cluster	BPTF AHI1 TLN1 ROCK1 RAD50	3.48e-05	196	84	5	7bced0cc2112697593c478fa291b8ed3941fb811
ToppCell	Severe-B_intermediate-6\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	TLN1 LRRK2 NCOA7 DEK ZEB2	3.65e-05	198	84	5	8402421dc060926e968efe39a4e907f1e8ae5b1f
ToppCell	(04)_Interm._basal>secr.-(2)_GFP_FOXI1\|(04)_Interm._basal>secr. / shred by cell type by condition	BPTF NCOA7 ROCK1 EEA1 RAD50	3.74e-05	199	84	5	53ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	EOMES TBX21 EIF3C EIF3CL RAD50	3.83e-05	200	84	5	2281debd86e5d92e8fe0397aec9ef670800f7471
Drug	Harmaline hydrochloride dihydrate [6027-98-1]; Down 200; 14uM; PC3; HT_HG-U133A	CYLC1 BRCA2 TLN1 DNAH17 APC SEPTIN11 ARHGEF2	8.42e-06	197	84	7	6623_DN
Drug	Fipexide hydrochloride [34161-23-4]; Down 200; 9.4uM; HL60; HG-U133A	NUMA1 ROCK1 RPRD2 INPP5F R3HDM1 SUCO ZEB2	8.70e-06	198	84	7	1560_DN
Disease	Hereditary Breast and Ovarian Cancer Syndrome	BRCA2 PALB2 RAD50	7.92e-06	14	84	3	C0677776
Disease	breast cancer (implicated_via_orthology)	BRCA2 APC RAD50	4.89e-05	25	84	3	DOID:1612 (implicated_via_orthology)
Disease	Hereditary Nonpolyposis Colorectal Cancer	PMS1 APC PALB2	7.71e-05	29	84	3	C1333990
Disease	hereditary breast ovarian cancer syndrome (is_implicated_in)	BRCA2 PALB2	7.96e-05	5	84	2	DOID:5683 (is_implicated_in)
Disease	Breast Cancer, Familial	BRCA2 PALB2 RAD50	8.55e-05	30	84	3	C0346153
Disease	Cerebellar Diseases	AHI1 ZEB2	1.67e-04	7	84	2	C0007760
Disease	Pancreatic carcinoma, familial	BRCA2 PALB2	2.85e-04	9	84	2	C2931038
Disease	medulloblastoma (is_implicated_in)	BRCA2 APC	3.55e-04	10	84	2	DOID:0050902 (is_implicated_in)
Disease	Prostatic Neoplasms	PMS1 THYN1 BRCA2 APC NCOA7 RPRD2 MGA PALB2	3.73e-04	616	84	8	C0033578
Disease	Malignant neoplasm of prostate	PMS1 THYN1 BRCA2 APC NCOA7 RPRD2 MGA PALB2	3.73e-04	616	84	8	C0376358
Disease	Medulloblastoma	BRCA2 APC PALB2	3.96e-04	50	84	3	C0025149
Disease	Benign tumor of pancreas	BRCA2 APC	6.12e-04	13	84	2	C0347284
Disease	pimelic acid measurement, 3-methyladipic acid measurement	ABCA1 CCDC73	7.13e-04	14	84	2	EFO_0010449, EFO_0010524
Disease	Fanconi anemia	BRCA2 PALB2	7.13e-04	14	84	2	cv:C0015625
Disease	autism spectrum disorder (is_implicated_in)	AHI1 MBD5	9.36e-04	16	84	2	DOID:0060041 (is_implicated_in)
Disease	Bone marrow hypocellularity	BRCA2 PALB2	1.19e-03	18	84	2	C1855710
Disease	non-small cell lung carcinoma	SECISBP2L BPTF BRCA2	1.30e-03	75	84	3	EFO_0003060
Disease	Pancreatic carcinoma	BRCA2 APC	1.33e-03	19	84	2	C0235974
Disease	Adenocarcinoma of prostate	BRCA2 PALB2	1.47e-03	20	84	2	C0007112
Disease	Joubert syndrome 1	AHI1 PIBF1	1.62e-03	21	84	2	C4551568
Disease	transitional cell carcinoma (is_implicated_in)	APC RAD50	1.78e-03	22	84	2	DOID:2671 (is_implicated_in)
Disease	Parkinson disease	LRRK2 GIGYF2	1.78e-03	22	84	2	cv:C0030567
Disease	heart failure	BPTF ZNF638 INPP5F ZEB2	1.95e-03	185	84	4	EFO_0003144
Disease	Fanconi Anemia	BRCA2 PALB2	2.30e-03	25	84	2	C0015625
Disease	Neurodevelopmental Disorders	GABRB2 NEXMIF GIGYF2	2.40e-03	93	84	3	C1535926
Disease	Bipolar Disorder	GABRB2 GLYAT BRCA2 SEPTIN11 MBD5 PALB2	2.43e-03	477	84	6	C0005586
Disease	Pancytopenia	BRCA2 PALB2	2.49e-03	26	84	2	C0030312
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	APC PALB2	2.49e-03	26	84	2	C0009405
Disease	Hereditary non-polyposis colorectal cancer syndrome	PMS1 PALB2	2.68e-03	27	84	2	C1112155
Disease	Malignant tumor of breast	BRCA2 PALB2	2.68e-03	27	84	2	cv:C0006142
Disease	Breast neoplasm	BRCA2 PALB2	2.68e-03	27	84	2	cv:C1458155
Disease	Familial cancer of breast	BRCA2 PALB2	2.68e-03	27	84	2	cv:C0346153

Protein segments in the cluster

Peptide	Gene	Start	Entry
KLKLTNNKGANNNNT	EOMES	371	O95936
KLKDRAQKLANQASN	nan	486	Q9N2J8
NTNNLKKSTRVTKNK	AHI1	86	Q8N157
QKQQKAALLKNNTAL	ARHGEF2	91	Q92974
TLQQIKKSSSNLKLQ	ABCA1	131	O95477
NGLKNKNSQLKTLLA	CHIA	81	Q9BZP6
EQKRSKQNATKLSAL	BPTF	2726	Q12830
NENQSLKKNISALIK	CASP8AP2	106	Q9UKL3
SISAAQNALKKQINS	R3HDM1	1061	Q15032
KNKKQRSNLQATSLI	RBM41	386	Q96IZ5
LSNTDVQAAKNKLKA	UQCRC2	366	P22695
NKKNTSNKIAQDKLN	RAD50	931	Q92878
KANKQKASARNLFLT	INO80	291	Q9ULG1
TKSKNNQLFVNLKNV	MEGF10	951	Q96KG7
RNIKNKKSTNNRASS	MAP9	356	Q49MG5
EKASNKTVQNLSKVQ	MGA	2091	Q8IWI9
TQKENLFQTNKLKSL	ITPRID1	361	Q6ZRS4
SNEKKSQSQNLFSVK	NLRP10	591	Q86W26
QQSSSLPSKKNKQSA	HIPK1	836	Q86Z02
NQSNQLTKLDVKKFS	LRRC53	666	A6NM62
QNLAAIKSFKVKQTQ	GLYAT	116	Q6IB77
TALQSRSTNIKKAQK	KIAA1586	541	Q9HCI6
KKQKQQSAKSAAAGN	PDE6A	826	P16499
QNSKTVSKNCSQKDK	CYLC1	186	P35663
KNVNQSTKRKIQSSL	OBI1	701	Q5W0B1
NSFSKQSKQKNFLLV	LRRK2	2251	Q5S007
QRQKKAAEKAASANN	GABRB2	336	P47870
AQNNLTKAVDAFKKS	MFSD11	216	O43934
KNSLLKQQNNAAVKI	LRRIQ1	276	Q96JM4
KNKNKDASKNLNLSN	PALB2	441	Q86YC2
SKTELKQNNQSLASK	PRICKLE1	451	Q96MT3
NKNNAKALSTLRQKI	EIF3C	131	Q99613
QKLKSSVNELTQKNQ	EEA1	291	Q15075
NKNNAKALSTLRQKI	EIF3CL	131	B5ME19
TRNSKINAENKAKIN	CCNB1	6	P14635
KNKNRSKISNKDQSN	ICE1	1551	Q9Y2F5
QNQKSNLKTKVKTAF	C3orf49	76	Q96BT1
STNKNKNNASLSKSV	GIGYF2	1091	Q6Y7W6
KNKNAAIKLSISNSN	BRCA2	1821	P51587
QLKANLTKSQNEFKI	DNAH17	3576	Q9UFH2
NVKKADSSTTKKNQN	DEK	281	P35659
SANSKLLLKNSDKNV	CCDC73	716	Q6ZRK6
DQAQKSKTAVVKNTN	CC2D1B	736	Q5T0F9
ASQILQNKKHKNSQL	FAM98B	126	Q52LJ0
SAAAKAQLANQNKLA	MBD5	581	Q9P267
QALKRAQASKSKANI	CCDC38	236	Q502W7
SLISTAKTQNQKQRK	FOXN2	416	P32314
ELQTAKKNVNQAKLS	KIF4B	581	Q2VIQ3
QLQAQTKFTKKELQS	KCNIP3	81	Q9Y2W7
STTFKTQKQLKENLN	RPRD2	146	Q5VT52
FSSLNQKVKQTKSNV	INPP5F	781	Q9Y2H2
NLAQKHKLKTSLSNQ	PMS1	661	P54277
KSTVSLNKNKQLSNS	C18orf63	531	Q68DL7
SDQASKVQQQKLKAV	NUMA1	1561	Q14980
KKSKLIRSQSFNNQA	PPP4R4	766	Q6NUP7
QKKKAAAQLLQSQAQ	SEPTIN11	396	Q9NVA2
KQSNLATGLSKAKSQ	SH3D19	376	Q5HYK7
KAQQKLQASLSVAVN	TOP6BL	386	Q8N6T0
KKQAKQNAETASAVA	NCOA7	21	Q8NI08
SSQKNTRKKSLKGNN	NEXMIF	1191	Q5QGS0
SFLSKQAENIKAQQK	ODAD4	146	Q96NG3
QQGQALASALKNKKK	GNL3L	536	Q9NVN8
SQKKKALAAALATAQ	SECISBP2L	446	Q93073
KIKSSKNSAANRELQ	PRG4	181	Q92954
SDNKDSKKQNLKNNS	APC	1806	P25054
SKKQNLKNNSKVFND	APC	1811	P25054
KTLSHKLNASAKNLQ	CNKSR2	86	Q8WXI2
KATALQKFLAQNRKN	TSGA13	66	Q96PP4
NSKSIKENSNAAIIK	GTF2H1	291	P32780
NNSVKTIALNLKKSD	GTF2H1	366	P32780
SSIKKAQQAVANKAL	STAU2	56	Q9NUL3
KQKLLSANQNIRSKA	RSPH14	196	Q9UHP6
TSAANFSLNNSKKLK	TMEM181	181	Q9P2C4
TNAAAQNAIKKKLVQ	TLN1	901	Q9Y490
NLNKEKSALLQTKNQ	PIBF1	656	Q8WXW3
KENSSKSVSNLNKHQ	ZNF840P	526	A6NDX5
NALQKQANSKKITNV	RFX7	1141	Q2KHR2
QKAFNKTIVKLQNTS	SUCO	951	Q9UBS9
LKKVSQNSQLANEKL	ROCK1	526	Q13464
QKTSATKNCLKNLSS	THYN1	41	Q9P016
KQNSNLLNQSKIKTA	ZNF354B	196	Q96LW1
KTSDNKSQSKSNKQL	TMTC3	861	Q6ZXV5
KKEFSNSNNLDNKST	ZEB2	866	O60315
ENSSPNRNSSKKNKQ	TUT4	46	Q5TAX3
NKTLYKAKSSCNQNL	TERB1	511	Q8NA31
KLKLTNNKGASNNVT	TBX21	241	Q9UL17
NNKTLAEQNTKNPKS	ZNF638	1506	Q14966
RKLQNQVLDSKNFKS	WDR64	256	B1ANS9