Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	ubiquitin-dependent protein catabolic process via the N-end rule pathway	UBR1 UBR3	2.42e-05	4	42	2	GO:0071596
GeneOntologyCellularComponent	outer dynein arm	DNAH5 DNAH8	2.69e-04	12	43	2	GO:0036157
HumanPheno	Elevated gamma-glutamyltransferase level	GPD1 UBR1 TNPO3	8.44e-05	47	10	3	HP:0030948
HumanPheno	Abnormal gamma-glutamyltransferase level	GPD1 UBR1 TNPO3	9.00e-05	48	10	3	HP:0034444
Domain	zf-UBR	UBR1 UBR3	1.08e-04	7	43	2	PF02207
Domain	Znf_UBR	UBR1 UBR3	1.08e-04	7	43	2	IPR003126
Domain	ZnF_UBR1	UBR1 UBR3	1.08e-04	7	43	2	SM00396
Domain	ZF_UBR	UBR1 UBR3	1.08e-04	7	43	2	PS51157
Domain	Dynein_heavy_dom-1	DNAH5 DNAH8	1.44e-04	8	43	2	IPR013594
Domain	DHC_N1	DNAH5 DNAH8	1.44e-04	8	43	2	PF08385
Domain	PNMA	ZCCHC18 PNMA5	2.81e-04	11	43	2	PF14893
Domain	PNMA	ZCCHC18 PNMA5	2.81e-04	11	43	2	IPR026523
Domain	ATPase_dyneun-rel_AAA	DNAH5 DNAH8	4.63e-04	14	43	2	IPR011704
Domain	Dynein_heavy_chain_D4_dom	DNAH5 DNAH8	4.63e-04	14	43	2	IPR024317
Domain	Dynein_HC_stalk	DNAH5 DNAH8	4.63e-04	14	43	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH5 DNAH8	4.63e-04	14	43	2	IPR013602
Domain	DHC_N2	DNAH5 DNAH8	4.63e-04	14	43	2	PF08393
Domain	MT	DNAH5 DNAH8	4.63e-04	14	43	2	PF12777
Domain	AAA_8	DNAH5 DNAH8	4.63e-04	14	43	2	PF12780
Domain	AAA_5	DNAH5 DNAH8	4.63e-04	14	43	2	PF07728
Domain	DHC_fam	DNAH5 DNAH8	5.33e-04	15	43	2	IPR026983
Domain	Dynein_heavy_dom	DNAH5 DNAH8	5.33e-04	15	43	2	IPR004273
Domain	Dynein_heavy	DNAH5 DNAH8	5.33e-04	15	43	2	PF03028
Domain	Apc4_WD40_dom	WDR53 WDR47	9.58e-04	20	43	2	IPR024977
Domain	ANAPC4_WD40	WDR53 WDR47	9.58e-04	20	43	2	PF12894
Domain	AAA+_ATPase	ABCC5 DNAH5 DNAH8	4.42e-03	144	43	3	IPR003593
Domain	AAA	ABCC5 DNAH5 DNAH8	4.42e-03	144	43	3	SM00382
Domain	WD40_repeat_CS	WDFY2 WDR53 WDR47	6.34e-03	164	43	3	IPR019775
Pubmed	Genetic Association of the PARL-ABCC5-HTR3D-HTR3C Locus With Primary Angle-Closure Glaucoma in Chinese.	ABCC5 HTR3C	9.37e-06	4	44	2	28813580
Pubmed	ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma.	ABCC5 HTR3C	9.37e-06	4	44	2	24603532
Pubmed	Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems.	UBR1 UBR3	2.34e-05	6	44	2	17462990
Pubmed	Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway.	UBR1 UBR3	2.34e-05	6	44	2	10805755
Pubmed	Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.	DNAH5 DNAH8	3.27e-05	7	44	2	31178125
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH5 DNAH8	3.27e-05	7	44	2	9256245
Pubmed	Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.	UBR1 UBR3	3.27e-05	7	44	2	21816346
Pubmed	Transport of the outer dynein arm complex to cilia requires a cytoplasmic protein Lrrc6.	IFT46 DNAH5	5.60e-05	9	44	2	27353389
Pubmed	Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.	UBR1 UBR3	5.60e-05	9	44	2	17855541
Pubmed	The E3 ubiquitin ligase APC/CCdh1 degrades MCPH1 after MCPH1-βTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis.	RBM39 NCCRP1 WDR53	7.81e-05	65	44	3	29150431
Pubmed	HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.	UBR1 UBR3	1.02e-04	12	44	2	17360488
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH5 DNAH8	1.41e-04	14	44	2	9373155
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	SDK2 DNAH5 TNPO3 RBM39	2.19e-04	234	44	4	36243803
Pubmed	A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells.	MIA2 HAUS1 RECQL5	3.24e-04	105	44	3	23284306
Pubmed	Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos.	SPTAN1 AXIN2	4.99e-04	26	44	2	37228654
Pubmed	Interactome and Ubiquitinome Analyses Identify Functional Targets of Herpes Simplex Virus 1 Infected Cell Protein 0.	DNAH5 RBM39 SPTAN1	5.27e-04	124	44	3	35516420
Pubmed	Wnt regulates amino acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos.	KLHDC4 AXIN2	6.65e-04	30	44	2	31789450
Pubmed	Primary Ciliary Dyskinesia	DNAH5 DNAH8	7.57e-04	32	44	2	20301301
Pubmed	Analysis of mouse embryonic patterning and morphogenesis by forward genetics.	ZNF568 AXIN2	8.06e-04	33	44	2	15755804
Pubmed	KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.	UBR1 UBR3	8.06e-04	33	44	2	25582440
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DNER NRBP1 ABCC5 MIA2 TXNDC11 SPTAN1 WDR47	1.07e-03	1285	44	7	35914814
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR1 UBR3	4.83e-05	7	28	2	785
GeneFamily	Paraneoplastic Ma antigens	ZCCHC18 PNMA5	1.26e-04	11	28	2	671
GeneFamily	Dyneins, axonemal	DNAH5 DNAH8	3.10e-04	17	28	2	536
GeneFamily	WD repeat domain containing	WDFY2 WDR53 WDR47	7.54e-03	262	28	3	362
ToppCell	Bac-SEP-Lymphocyte-B-B_intermediate\|Bac-SEP / Disease, Lineage and Cell Type	GPD1 PNMA5 MAB21L3 DNAH8	1.92e-05	161	44	4	bcd122af09cbb99d1816200d9c367af8b7f36873
ToppCell	ASK454-Immune-NK_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	SLFN12L MIA2 KLHDC4 GFOD1	2.37e-05	170	44	4	84705434234bf2fbb5256bd5a1f6ab54c01c5a51
ToppCell	ASK454-Immune-NK_cell\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	SLFN12L MIA2 KLHDC4 GFOD1	2.48e-05	172	44	4	c9e738c3540ee09b08805b1cdb66b4a0d9d40d33
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DNER SDK2 WDFY2 SNX10	2.54e-05	173	44	4	4bc6d93716f093b460c8b047199db8cab5fea720
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DNER SDK2 WDFY2 SNX10	3.03e-05	181	44	4	e0abf2707d9e0aa942c657eef7d2cbcd02f060dd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DNER ABCC5 WDFY2 SNX10	3.59e-05	189	44	4	7eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DNER ABCC5 WDFY2 SNX10	3.59e-05	189	44	4	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Myeloid\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ABCC5 MAST3 WDR53 SNX10	4.48e-05	200	44	4	cc8368665bc6bb7c4f39632ccff07ceaa98a7b65
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Myeloid-Megakaryocyte\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ABCC5 MAST3 WDR53 SNX10	4.48e-05	200	44	4	0d76b006d8e8b32174e65e400acd0674354b962c
Computational	Genes in the cancer module 332.	HAUS1 RBM39 WDR47	6.34e-05	45	19	3	MODULE_332
Disease	Colorectal Carcinoma	ABCC5 HTR3C ZNF569 DNAH8 AXIN2	3.43e-03	702	43	5	C0009402
Disease	eosinophil count	ABCC5 SLFN12L ERMP1 HAUS1 ZNF568 TXNDC11 MAST3	5.35e-03	1488	43	7	EFO_0004842
Disease	S-6-hydroxywarfarin to S-warfarin ratio measurement	WDR53 STON2	7.33e-03	88	43	2	EFO_0803332
Disease	Colorectal Neoplasms	ABCC5 ZNF569 AXIN2	7.66e-03	277	43	3	C0009404

Protein segments in the cluster

Peptide	Gene	Start	Entry
WLPDIFIVESMDVDQ	HTR3C	121	Q8WXA8
AVFEEIWEDETVLPM	AXIN2	816	Q9Y2T1
WIEVQVSEEHPEGMV	ERMP1	846	Q7Z2K6
MFNPQTEEEVGWDTE	RBM39	431	Q14498
FQEMLDEEDQDWFIP	PAIP2B	61	Q9ULR5
LDDEQPAITVMDWFE	NCCRP1	171	Q6ZVX7
DTWMLPDVNERIEQF	CWF19L2	56	Q2TBE0
FIDDINMPVINEWGD	DNAH8	2521	Q96JB1
EVKEVEQGEEPWIME	PMS2P3	61	Q13401
DPEGLQQWLEVEQFM	MAB21L3	106	Q8N8X9
MDTEEGVEVVWNEVQ	NRBP1	86	Q9UHY1
DWPQEGEVTFENAEM	ABCC5	1186	O15440
DIDTLMQEWSPEFEE	IFT46	206	Q9NQC8
QFDPRVTMWVFEEDI	GPD1	31	P21695
EELFGQVVSDEIMWP	MAST3	586	O60307
SPQDGQVVWQEMIEE	FBXO47	261	Q5MNV8
QVVWQEMIEEPTDEF	FBXO47	266	Q5MNV8
ALVEMDPETQEWLEE	KLHDC4	476	Q8TBB5
VVEMKWDQVEVIPDI	DNER	186	Q8NFT8
AWEPEQEEEVTMVTA	SDK2	831	Q58EX2
IDDVNMPIINEWGDQ	DNAH5	2656	Q8TE73
WEEVVVESMEQDRIP	MIA2	196	Q96PC5
TGEWQNIAIMTEEPE	GFOD1	356	Q9NXC2
MEPQEERETQVAAWL	HAUS1	1	Q96CS2
MDIVDAEQEAPVEGW	RNF215	96	Q9Y6U7
MPEEVVNAVEDWDSQ	RGMA	296	Q96B86
LQEDEEVEMEAISWQ	STON2	196	Q8WXE9
NMSPEEIEAWEQEQL	CLCN1	796	P35523
ETDFVEVPSQMLENW	NLN	521	Q9BYT8
QVTEIMPIWQVSEVE	PNMA5	181	Q96PV4
VQNDWMEEKVPVIVA	RECQL5	301	O94762
WDEVLQFIQPLECME	WDR47	61	O94967
IVVWNMDVERQETPE	WDFY2	266	Q96P53
VIFKLEQEEEPWVME	ZNF568	96	Q3ZCX4
TEKEWIQFMVDSEPV	SLFN12L	351	Q6IEE8
VANVEEEEAWINEKM	SPTAN1	1876	Q13813
IEVDPDWEAAIAIQM	UBR1	526	Q8IWV7
PLWITNLQEDETEEM	WDR53	171	Q7Z5U6
MFPEQQKEEFVSVWV	SNX10	1	Q9Y5X0
PDVAEVLWEIMQVDR	TNPO3	851	Q9Y5L0
IDVSQNDLPWEFMVD	TXNDC11	746	Q6PKC3
VIFKLEQEEEPWVME	ZNF569	56	Q5MCW4
AEVWDQEFDPVMVIL	UBR3	856	Q6ZT12
IQVNEVLPDWSMSEE	ZCCHC18	66	P0CG32
VTIEFTQEEWQQMAP	ZNF510	51	Q9Y2H8