Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity	PDE1C PDE1B	7.46e-06	3	32	2	GO:0048101
GeneOntologyMolecularFunction	calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity	PDE1C PDE1B	7.46e-06	3	32	2	GO:0004117
GeneOntologyMolecularFunction	A-type (transient outward) potassium channel activity	KCND1 KCND3	1.49e-05	4	32	2	GO:0005250
GeneOntologyMolecularFunction	phosphoric diester hydrolase activity	PDE1C SMPDL3B PDE1B	4.98e-04	97	32	3	GO:0008081
GeneOntologyMolecularFunction	3',5'-cyclic-AMP phosphodiesterase activity	PDE1C PDE1B	5.63e-04	22	32	2	GO:0004115
GeneOntologyMolecularFunction	3',5'-cyclic-GMP phosphodiesterase activity	PDE1C PDE1B	6.72e-04	24	32	2	GO:0047555
GeneOntologyMolecularFunction	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE1C PDE1B	7.29e-04	25	32	2	GO:0004114
GeneOntologyMolecularFunction	cyclic-nucleotide phosphodiesterase activity	PDE1C PDE1B	8.52e-04	27	32	2	GO:0004112
GeneOntologyMolecularFunction	outward rectifier potassium channel activity	KCND1 KCND3	8.52e-04	27	32	2	GO:0015271
Domain	DUF3399	KCND1 KCND3	9.07e-06	3	33	2	PF11879
Domain	K_chnl_volt-dep_Kv4	KCND1 KCND3	9.07e-06	3	33	2	IPR003975
Domain	Shal-type	KCND1 KCND3	9.07e-06	3	33	2	PF11601
Domain	PDEase_N	PDE1C PDE1B	9.07e-06	3	33	2	IPR013706
Domain	PDEase_I_N	PDE1C PDE1B	9.07e-06	3	33	2	PF08499
Domain	Shal-type_N	KCND1 KCND3	9.07e-06	3	33	2	IPR021645
Domain	K_chnl_volt-dep_Kv4_C	KCND1 KCND3	9.07e-06	3	33	2	IPR024587
Domain	PDEase	PDE1C PDE1B	5.08e-04	19	33	2	IPR023088
Domain	PDEase_I	PDE1C PDE1B	6.23e-04	21	33	2	PF00233
Domain	PDEASE_I	PDE1C PDE1B	6.23e-04	21	33	2	PS00126
Domain	PDEase_CS	PDE1C PDE1B	6.23e-04	21	33	2	IPR023174
Domain	-	PDE1C PDE1B	6.84e-04	22	33	2	1.10.1300.10
Domain	PDEase_catalytic_dom	PDE1C PDE1B	7.48e-04	23	33	2	IPR002073
Domain	HDc	PDE1C PDE1B	8.15e-04	24	33	2	SM00471
Domain	HD/PDEase_dom	PDE1C PDE1B	8.15e-04	24	33	2	IPR003607
Domain	K_chnl_volt-dep_Kv	KCND1 KCND3	1.03e-03	27	33	2	IPR003968
Domain	VG_K_chnl	KCND1 KCND3	1.54e-03	33	33	2	IPR028325
Domain	BTB_2	KCND1 KCND3	3.94e-03	53	33	2	PF02214
Domain	T1-type_BTB	KCND1 KCND3	3.94e-03	53	33	2	IPR003131
Domain	Channel_four-helix_dom	KCND1 KCND3	4.55e-03	57	33	2	IPR027359
Domain	-	KCND1 KCND3	4.55e-03	57	33	2	1.20.120.350
Domain	RNaseH-like_dom	SETMAR FAM200B	6.60e-03	69	33	2	IPR012337
Pathway	REACTOME_CAM_PDE_1_ACTIVATION	PDE1C PDE1B	4.88e-05	6	26	2	MM14494
Pathway	REACTOME_PHASE_1_INACTIVATION_OF_FAST_NA_CHANNELS	KCND1 KCND3	6.83e-05	7	26	2	M27457
Pathway	REACTOME_PHASE_1_INACTIVATION_OF_FAST_NA_CHANNELS	KCND1 KCND3	6.83e-05	7	26	2	MM15199
Pathway	WP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION	PDE1C GUCY1B2 PDE1B	1.37e-04	55	26	3	M39763
Pubmed	Unique clustering of A-type potassium channels on different cell types of the main olfactory bulb.	KCND1 KCND3	2.62e-06	3	33	2	18371079
Pubmed	Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+.	PDE1C PDE1B	2.62e-06	3	33	2	18335582
Pubmed	Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons.	PDE1C PDE1B	2.62e-06	3	33	2	7568196
Pubmed	Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes.	PDE1C PDE1B	2.62e-06	3	33	2	17726023
Pubmed	A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase.	PDE1C PDE1B	2.62e-06	3	33	2	1326532
Pubmed	Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase.	PDE1C PDE1B	2.62e-06	3	33	2	9003415
Pubmed	Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA).	KCND1 KCND3	2.62e-06	3	33	2	10729221
Pubmed	Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.	BAK1 USP9X	5.23e-06	4	33	2	20023629
Pubmed	Mechanisms of MCL-1 Protein Stability Induced by MCL-1 Antagonists in B-Cell Malignancies.	BAK1 USP9X	1.83e-05	7	33	2	36346691
Pubmed	Rab18 and a Rab18 GEF complex are required for normal ER structure.	RAB5A RAB3GAP2	3.13e-05	9	33	2	24891604
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	BAK1 ADAM30 LLGL2 DNAH10 KCND3 USP9X	5.72e-05	730	33	6	34857952
Pubmed	Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases.	PDE1C PDE1B	6.77e-05	13	33	2	8557689
Pubmed	Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects.	BAK1 USP9X	9.10e-05	15	33	2	30970248
Pubmed	Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein.	KCND1 KCND3	9.10e-05	15	33	2	10479680
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	CORO1B SNRNP200 USP9X RAB3GAP2 NAT10	1.59e-04	549	33	5	38280479
Pubmed	Nuclear organization of nucleotide excision repair is mediated by RING1B dependent H2A-ubiquitylation.	SNRNP200 RPS7 NAT10	1.65e-04	112	33	3	28416769
Pubmed	Dorsal root ganglion axon bifurcation tolerates increased cyclic GMP levels: the role of phosphodiesterase 2A and scavenger receptor Npr3.	PDE1C PDE1B	1.81e-04	21	33	2	27740716
Pubmed	Overview of PDEs and their regulation.	PDE1C PDE1B	2.58e-04	25	33	2	17307970
Pubmed	Immunoprecipitation and mass spectrometry defines an extensive RBM45 protein-protein interaction network.	SNRNP200 USP9X RPS7	2.93e-04	136	33	3	26979993
Pubmed	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.	PDE1C PDE1B	3.02e-04	27	33	2	11156964
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	GUCY1B2 DNAH10 SNRNP200 USP9X RAB3GAP2 RPS7 NAT10	3.20e-04	1425	33	7	30948266
Pubmed	Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.	SNRNP200 NAT10	3.25e-04	28	33	2	19596686
Pubmed	Proteomic analysis of complexes formed by human topoisomerase I.	SNRNP200 NAT10	4.25e-04	32	33	2	15848144
Pubmed	Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics.	SNRNP200 USP9X RPS7 NAT10	4.65e-04	384	33	4	31059266
Pubmed	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.	APOBEC3D CORO1B SNRNP200 RPS7 NAT10	5.07e-04	707	33	5	19738201
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	CORO1B SNRNP200 USP9X RAB3GAP2 RPS7	5.10e-04	708	33	5	39231216
Pubmed	The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.	CORO1B SNRNP200 RPS7 NAT10	6.33e-04	417	33	4	36537216
Pubmed	Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.	SMPDL3B SNRNP200 RPS7 NAT10	6.56e-04	421	33	4	34650049
Pubmed	International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.	KCND1 KCND3	6.66e-04	40	33	2	16382104
Interaction	PDE1C interactions	PDE1C PDE1B RPS7	1.03e-06	13	32	3	int:PDE1C
GeneFamily	Phosphodiesterases	PDE1C PDE1B	3.84e-04	24	22	2	681
GeneFamily	Potassium voltage-gated channels	KCND1 KCND3	1.07e-03	40	22	2	274
ToppCell	ICU-NoSEP-Myeloid-cDC1\|ICU-NoSEP / Disease, Lineage and Cell Type	TSPAN6 PDE1C SMPDL3B CD200R1L KCND3	1.93e-07	177	33	5	33cd2c183ee8b597012efcbcae72131ac6beaf4e
Disease	Mammary Neoplasms, Human	SLC2A10 DPYD LLGL2 ZNF404 RPS7	2.37e-04	525	32	5	C1257931
Disease	Mammary Carcinoma, Human	SLC2A10 DPYD LLGL2 ZNF404 RPS7	2.37e-04	525	32	5	C4704874
Disease	Mammary Neoplasms	SLC2A10 DPYD LLGL2 ZNF404 RPS7	2.41e-04	527	32	5	C1458155
Disease	Breast Carcinoma	SLC2A10 DPYD LLGL2 ZNF404 RPS7	2.65e-04	538	32	5	C0678222
Disease	multiple sclerosis symptom measurement	DNAH10 SLC25A48	1.14e-03	46	32	2	EFO_0803536
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	LLGL2 DNAH10 RPS7	1.82e-03	224	32	3	EFO_0004530, EFO_0008317
Disease	carcinoma (implicated_via_orthology)	LLGL2 RAB5A	2.20e-03	64	32	2	DOID:305 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FLTQVTGRIFVQAHF	CAPZA3	181	Q96KX2
SDVFQHVERIQGFRK	FAM200B	451	P0CF97
HSAVFRKRGVFRNQV	APOBEC3D	241	Q96AK3
GVVLLGQFVVRRFFK	BAK1	196	Q16611
VVRQSKFRHVFGQPV	CORO1B	6	Q9BR76
ARRVFIVFRKGFVNI	DPYD	356	Q12882
LVLRFVKGQFHEFQE	RAB5A	36	P20339
ARFFVRSIEHLKQIF	RAB3GAP2	1031	Q9H2M9
VFRVFRIFKFSRHSQ	KCND1	296	Q9NSA2
VFRVFRIFKFSRHSQ	KCND3	291	Q9UK17
FGLFDHQQRRQVFVK	LLGL2	611	Q6P1M3
QFQKRRFTLSFGHRQ	SLC2A10	511	O95528
KVVRKHHRVIAGQFF	SMPDL3B	261	Q92485
TGFVFFQRINHVRKV	CD200R1L	256	Q6Q8B3
KFRSIVHAVQAGIFV	PDE1B	121	Q01064
RFKSIVHAVQAGIFV	PDE1C	126	Q14123
HGRQVTVQEFALFFT	F8	1886	P00451
FNKAVIRVNVFREHR	NAT10	351	Q9H0A0
VNVIVVFLRQFHVFD	GPRC6A	271	Q5T6X5
LSVVFVFFRQVIGNH	ADAM30	701	Q9UKF2
FRFHVVKVYNRQTVQ	CBLN3	126	Q6UW01
HRGKVNFFRQVVISP	GADL1	486	Q6ZQY3
FFHAVVQERRKFGKI	DNAH10	4026	Q8IVF4
FRGKHLSFVVRFPNQ	USP9X	881	Q93008
RIFGHRIITVNFAIN	RGSL1	866	A5PLK6
KFSGKHVVFIAQRRI	RPS7	86	P62081
IHPQVTFNIFSIRRF	GUCY1B2	236	O75343
RVVQKGLQFHFQVFK	SETMAR	131	Q53H47
KVFFRGITVNAVRGF	SLC25A48	271	Q6ZT89
QFIKEAHGNVFRRVA	UNC80	936	Q8N2C7
VAAIVGFVFRHEIKN	TSPAN6	106	O43657
KAFVVFQHFIRHRKI	ZNF404	166	Q494X3
GFNTFDFIKVLRQHR	SNRNP200	311	O75643