Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	RASGRF2 ALS2 ALS2CL DENND2B ARHGEF7 RASGEF1B FGD5 PLCE1 RGL4	1.17e-05	231	121	9	GO:0005085
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	RGPD2 RASGRF2 ALS2 ALS2CL DENND2B RGS1 ARHGEF7 RASGEF1B SESN2 FGD5 PLCE1 RGL4	6.01e-05	507	121	12	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	RGPD2 RASGRF2 ALS2 ALS2CL DENND2B RGS1 ARHGEF7 RASGEF1B SESN2 FGD5 PLCE1 RGL4	6.01e-05	507	121	12	GO:0030695
GeneOntologyMolecularFunction	rhodopsin kinase activity	GRK7 GRK1	1.09e-04	3	121	2	GO:0050254
GeneOntologyMolecularFunction	small GTPase binding	KNTC1 RGPD2 ALS2 ALS2CL ARHGEF7 DIAPH2 AFDN FGD5 PLCE1	1.50e-04	321	121	9	GO:0031267
GeneOntologyMolecularFunction	polypeptide N-acetylgalactosaminyltransferase activity	GALNT15 GALNT17 GALNT11	2.29e-04	20	121	3	GO:0004653
GeneOntologyMolecularFunction	GTPase binding	KNTC1 RGPD2 ALS2 ALS2CL ARHGEF7 DIAPH2 AFDN FGD5 PLCE1	3.50e-04	360	121	9	GO:0051020
GeneOntologyMolecularFunction	glial cell-derived neurotrophic factor receptor activity	GFRA2 GFRA3	3.60e-04	5	121	2	GO:0016167
GeneOntologyMolecularFunction	G protein-coupled receptor kinase activity	GRK7 GRK1	7.50e-04	7	121	2	GO:0004703
GeneOntologyMolecularFunction	clathrin light chain binding	CLTCL1 CLTC	7.50e-04	7	121	2	GO:0032051
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	RIPOR2 NTRK3 ALS2 PIAS2 GFRA3 GRK1 CASK MYO3A B3GNT2 ANAPC2 DIAPH2 MACF1 AFDN PARD3 NEXN	2.96e-05	748	120	15	GO:0048667
GeneOntologyBiologicalProcess	cell morphogenesis	LST1 SHROOM3 RIPOR2 NTRK3 ALS2 PIAS2 GFRA3 GRK1 CASK MYO3A ARHGEF7 B3GNT2 ANAPC2 DIAPH2 MACF1 AFDN FGD5 PARD3 NEXN	5.88e-05	1194	120	19	GO:0000902
GeneOntologyBiologicalProcess	regulation of cell morphogenesis	LST1 SHROOM3 PIAS2 CASK ARHGEF7 ANAPC2 MACF1 AFDN FGD5	6.93e-05	302	120	9	GO:0022604
Domain	Ricin_B_lectin	GALNT15 MRC1 GALNT17 GALNT11	1.91e-05	25	121	4	PF00652
Domain	RASGEF	RASGRF2 RASGEF1B PLCE1 RGL4	2.24e-05	26	121	4	PS00720
Domain	RICIN	GALNT15 MRC1 GALNT17 GALNT11	3.04e-05	28	121	4	SM00458
Domain	RICIN_B_LECTIN	GALNT15 MRC1 GALNT17 GALNT11	3.04e-05	28	121	4	PS50231
Domain	RASGEF_CAT	RASGRF2 RASGEF1B PLCE1 RGL4	3.51e-05	29	121	4	PS50009
Domain	RasGEF	RASGRF2 RASGEF1B PLCE1 RGL4	4.03e-05	30	121	4	PF00617
Domain	-	RASGRF2 RASGEF1B PLCE1 RGL4	4.03e-05	30	121	4	1.10.840.10
Domain	RASGEF_cat_dom	RASGRF2 RASGEF1B PLCE1 RGL4	4.03e-05	30	121	4	IPR001895
Domain	Ricin_B_lectin	GALNT15 MRC1 GALNT17 GALNT11	4.03e-05	30	121	4	IPR000772
Domain	RasGEF	RASGRF2 RASGEF1B PLCE1 RGL4	4.03e-05	30	121	4	SM00147
Domain	Ras_GEF_dom	RASGRF2 RASGEF1B PLCE1 RGL4	4.03e-05	30	121	4	IPR023578
Domain	Clathrin_H-chain_propeller_rpt	CLTCL1 CLTC	4.16e-05	2	121	2	IPR022365
Domain	Clathrin-link	CLTCL1 CLTC	4.16e-05	2	121	2	PF09268
Domain	-	CLTCL1 CLTC	4.16e-05	2	121	2	2.130.10.110
Domain	Clathrin_heavy_chain	CLTCL1 CLTC	4.16e-05	2	121	2	IPR016341
Domain	Clathrin_H-chain_propeller_N	CLTCL1 CLTC	4.16e-05	2	121	2	IPR001473
Domain	Clathrin_H-chain_link/propller	CLTCL1 CLTC	4.16e-05	2	121	2	IPR016025
Domain	Clathrin_propel	CLTCL1 CLTC	4.16e-05	2	121	2	PF01394
Domain	Clathrin_H-chain_linker_core	CLTCL1 CLTC	4.16e-05	2	121	2	IPR015348
Domain	-	RASGRF2 ALS2 ALS2CL ARHGEF7 FGD5	9.72e-05	71	121	5	1.20.900.10
Domain	DH-domain	RASGRF2 ALS2 ALS2CL ARHGEF7 FGD5	9.72e-05	71	121	5	IPR000219
Domain	Clathrin_H-chain_linker	CLTCL1 CLTC	1.24e-04	3	121	2	IPR012331
Domain	XPG_CS	ERCC5 EXO1	1.24e-04	3	121	2	IPR019974
Domain	CLH	CLTCL1 CLTC	1.24e-04	3	121	2	SM00299
Domain	XPG_I	ERCC5 EXO1	2.48e-04	4	121	2	PF00867
Domain	XPG-I_dom	ERCC5 EXO1	2.48e-04	4	121	2	IPR006086
Domain	XPG/Rad2	ERCC5 EXO1	2.48e-04	4	121	2	IPR006084
Domain	HhH2	ERCC5 EXO1	2.48e-04	4	121	2	IPR008918
Domain	5-3_exonuclease_C	ERCC5 EXO1	2.48e-04	4	121	2	IPR020045
Domain	XPG_1	ERCC5 EXO1	2.48e-04	4	121	2	PS00841
Domain	XPG_2	ERCC5 EXO1	2.48e-04	4	121	2	PS00842
Domain	HhH2	ERCC5 EXO1	2.48e-04	4	121	2	SM00279
Domain	XPGN	ERCC5 EXO1	2.48e-04	4	121	2	SM00485
Domain	XPGI	ERCC5 EXO1	2.48e-04	4	121	2	SM00484
Domain	-	RGPD2 CLTCL1 IFIT3 ZC3H7A CLTC ANAPC5 WDTC1	4.03e-04	207	121	7	1.25.40.10
Domain	XPG_DNA_repair_N	ERCC5 EXO1	4.11e-04	5	121	2	IPR006085
Domain	GDNF_rcpt	GFRA2 GFRA3	4.11e-04	5	121	2	IPR003438
Domain	XPG_N	ERCC5 EXO1	4.11e-04	5	121	2	PF00752
Domain	GDNF	GFRA2 GFRA3	6.14e-04	6	121	2	PF02351
Domain	GDNF	GFRA2 GFRA3	6.14e-04	6	121	2	SM00907
Domain	GDNF/GAS1	GFRA2 GFRA3	6.14e-04	6	121	2	IPR016017
Domain	TPR-like_helical_dom	RGPD2 CLTCL1 IFIT3 ZC3H7A CLTC ANAPC5 WDTC1	8.14e-04	233	121	7	IPR011990
Domain	Clathrin	CLTCL1 CLTC	8.56e-04	7	121	2	PF00637
Domain	GPCR_kinase	GRK7 GRK1	8.56e-04	7	121	2	IPR000239
Domain	CHCR	CLTCL1 CLTC	8.56e-04	7	121	2	PS50236
Domain	Glycos_transf_2	GALNT15 GALNT17 GALNT11	9.48e-04	30	121	3	PF00535
Domain	Glyco_trans_2-like	GALNT15 GALNT17 GALNT11	9.48e-04	30	121	3	IPR001173
Domain	RhoGEF	RASGRF2 ALS2 ARHGEF7 FGD5	1.11e-03	70	121	4	PF00621
Domain	DH_2	RASGRF2 ALS2 ARHGEF7 FGD5	1.11e-03	70	121	4	PS50010
Domain	Clathrin_H-chain/VPS_repeat	CLTCL1 CLTC	1.14e-03	8	121	2	IPR000547
Domain	RGS	GRK7 RGS1 GRK1	1.49e-03	35	121	3	PF00615
Domain	RGS	GRK7 RGS1 GRK1	1.49e-03	35	121	3	SM00315
Domain	RGS	GRK7 RGS1 GRK1	1.62e-03	36	121	3	PS50132
Domain	VPS9	ALS2 ALS2CL	1.81e-03	10	121	2	PS51205
Domain	VPS9	ALS2 ALS2CL	1.81e-03	10	121	2	PF02204
Domain	VPS9	ALS2 ALS2CL	1.81e-03	10	121	2	IPR003123
Domain	RGS	GRK7 RGS1 GRK1	2.04e-03	39	121	3	IPR016137
Domain	-	ERCC5 EXO1	2.63e-03	12	121	2	3.40.50.1010
Domain	TPR-contain_dom	RGPD2 IFIT3 ZC3H7A ANAPC5 WDTC1	2.95e-03	150	121	5	IPR013026
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RIPOR2 ZFYVE16 SCAF8 KHNYN ALS2 CSMD3 CLTC ACIN1 MACF1 ST18 PLCE1	2.35e-07	407	123	11	12693553
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SHROOM3 INPP5E GRK7 NTRK3 ALS2 LARP1B YWHAB DENND2B ITK CEP350 EXO1 MACF1 AFDN CEP152 PARD3	4.18e-07	861	123	15	36931259
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	KNTC1 RASGRF2 RPN2 KRT33A KRT33B USP11 UBR4 SPTLC1 ALS2 YWHAB AFAP1L1 S100A8 ARHGEF7 CLTC ACIN1 AFDN PARD3 DDX24	6.46e-07	1284	123	18	17353931
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	INPP5E ALS2 YWHAB ARHGEF7 CLTC ACIN1 AFDN PARD3	3.73e-06	255	123	8	15324660
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	KNTC1 SHROOM3 YWHAB PPP6C EXO1 AFDN CEP152 PARD3 PPP6R2 ANAPC5	4.49e-06	446	123	10	24255178
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	USP11 POLR2I PIAS2 YWHAB CEP350 S100A8 PPP6C ANAPC2 CLTC RPS19BP1 DDX24 ANAPC5	4.87e-06	670	123	12	22990118
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	POLR2I EZH2 YWHAB CASK MEX3A ACIN1 MACF1 PARD3 DDX24	5.51e-06	358	123	9	32460013
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	CLTCL1 RPN2 USP11 UBR4 YWHAB CEP350 S100A8 PPP6C PPP1R16B PARD3 PPP6R2	6.44e-06	573	123	11	28330616
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	RGPD2 SHROOM3 UBR4 GABBR2 YWHAB CASK PPP6C ARHGEF7 CLTC DIAPH2 MACF1 AFDN PARD3 PPP6R2	8.36e-06	963	123	14	28671696
Pubmed	A human MAP kinase interactome.	RIPOR2 PIAS2 YWHAB CEP350 S100A8 ZC3H7A ARHGEF7 CLTC DIAPH2 MACF1	9.50e-06	486	123	10	20936779
Pubmed	Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.	SHROOM3 KRT33B SPTLC1 YWHAB PRSS3P2 S100A8 CLTC RPS19BP1 MACF1 FHL2	9.85e-06	488	123	10	31324722
Pubmed	Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.	CLTCL1 CLTC	1.24e-05	2	123	2	8733129
Pubmed	Cell polarity factor Par3 binds SPTLC1 and modulates monocyte serine palmitoyltransferase activity and chemotaxis.	SPTLC1 PARD3	1.24e-05	2	123	2	19592499
Pubmed	The SCFFBXO46 ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence.	FBXO46 FBXO3	1.24e-05	2	123	2	30171069
Pubmed	Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities.	GRK7 GRK1	1.24e-05	2	123	2	15946941
Pubmed	CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function.	CLTCL1 CLTC	1.24e-05	2	123	2	29097553
Pubmed	The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.	CLTCL1 CLTC	1.24e-05	2	123	2	20065094
Pubmed	A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms.	KRT33A KRT33B	1.24e-05	2	123	2	7565656
Pubmed	Leu promotes C2C12 cell differentiation by regulating the GSK3β/β-catenin signaling pathway through facilitating the interaction between SESN2 and RPN2.	RPN2 SESN2	1.24e-05	2	123	2	38551359
Pubmed	ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics.	ALS2 ALS2CL	1.24e-05	2	123	2	17239822
Pubmed	Species-specific differences in expression of G-protein-coupled receptor kinase (GRK) 7 and GRK1 in mammalian cone photoreceptor cells: implications for cone cell phototransduction.	GRK7 GRK1	1.24e-05	2	123	2	11717351
Pubmed	A tale of two kinases in rods and cones.	GRK7 GRK1	1.24e-05	2	123	2	22183412
Pubmed	Differential expression of type I hair keratins.	KRT33A KRT33B	1.24e-05	2	123	2	1689759
Pubmed	Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling.	NTRK3 GFRA2 GFRA3	1.90e-05	15	123	3	20064391
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	RPN2 SCAF8 EZH2 PRSS3P2 ARHGEF7 ANAPC2 DIAPH2 AFDN PPP6R2 ANAPC5 PLCE1	2.08e-05	650	123	11	38777146
Pubmed	Image-based genome-wide siRNA screen identifies selective autophagy factors.	MYLK MYOM1 LARP1B ACIN1 ASB2 ZNF681	2.27e-05	159	123	6	22020285
Pubmed	Tagging genes with cassette-exchange sites.	SCAF8 UBR4 EZH2 MACF1 AFDN REXO1L1P ZNF681 ZNF292	2.69e-05	335	123	8	15741177
Pubmed	Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.	UBR4 ANAPC2 ANAPC5	2.83e-05	17	123	3	29033132
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	USP11 ARID3B CASK PPP6C DHCR24 ANAPC2 CLTC AFDN DDX24 ANAPC5	3.19e-05	560	123	10	35241646
Pubmed	Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.	CLTCL1 CLTC	3.71e-05	3	123	2	19509056
Pubmed	Evaluation of germline sequence variants of GFRA1, GFRA2, and GFRA3 genes in a cohort of Spanish patients with sporadic medullary thyroid cancer.	GFRA2 GFRA3	3.71e-05	3	123	2	12490080
Pubmed	Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.	CLTCL1 CLTC	3.71e-05	3	123	2	22891263
Pubmed	SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.	SPTLC1 PARD3	3.71e-05	3	123	2	18484747
Pubmed	Amino acid residues in GRK1/GRK7 responsible for interaction with S-modulin/recoverin.	GRK7 GRK1	3.71e-05	3	123	2	18266817
Pubmed	ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics.	ALS2 ALS2CL	3.71e-05	3	123	2	15388334
Pubmed	Endothelin-1 inhibits the epithelial Na+ channel through betaPix/14-3-3/Nedd4-2.	YWHAB ARHGEF7	3.71e-05	3	123	2	20338996
Pubmed	Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration.	CLTCL1 CLTC	3.71e-05	3	123	2	15133132
Pubmed	The RAIG family member, GPRC5D, is associated with hard-keratinized structures.	KRT33A KRT33B	3.71e-05	3	123	2	15086536
Pubmed	The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion.	AFDN PARD3	3.71e-05	3	123	2	30924770
Pubmed	Genetic association of the GDNF alpha-receptor genes with schizophrenia and clozapine response.	GFRA2 GFRA3	3.71e-05	3	123	2	20116071
Pubmed	Endofin recruits clathrin to early endosomes via TOM1.	ZFYVE16 CLTC	3.71e-05	3	123	2	15657082
Pubmed	Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor.	NTRK3 GFRA2 GFRA3	4.01e-05	19	123	3	24516396
Pubmed	High-throughput mapping of a dynamic signaling network in mammalian cells.	ITK MYO3A FBXO3 PPP6C ARHGEF7 PPP1R16B ANAPC5	4.09e-05	260	123	7	15761153
Pubmed	Functional proteomics mapping of a human signaling pathway.	ZFYVE16 UBR4 PIAS2 DENND2B CASK ANAPC2 MACF1 AFDN ASB2 FHL2	5.01e-05	591	123	10	15231748
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	KNTC1 RGPD2 ERCC5 CLTCL1 MYLK RPN2 KRT33A KRT33B UBR4 YWHAB ZC3H7A SEPHS1 CLTC ACIN1 MACF1 ZNF292	5.09e-05	1442	123	16	35575683
Pubmed	MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.	YWHAB PPP6C MACF1 PPP6R2	5.09e-05	57	123	4	29089450
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	SCAF8 UBR4 YWHAB DNAJC2 CASK ARHGEF7 KANK4 SCP2 PARD3	5.10e-05	475	123	9	31040226
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	SHROOM3 RPN2 NME2P1 YWHAB CASK LRRC53 ZNF611 MACF1 NEXN	7.10e-05	496	123	9	31343991
Pubmed	Artemin, a glial cell line-derived neurotrophic factor family member, induces TRPM8-dependent cold pain.	GFRA2 GFRA3	7.41e-05	4	123	2	23884957
Pubmed	Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1.	CASK AFDN	7.41e-05	4	123	2	10856295
Pubmed	GFRalpha-3, a protein related to GFRalpha-1, is expressed in developing peripheral neurons and ensheathing cells.	GFRA2 GFRA3	7.41e-05	4	123	2	9749804
Pubmed	Identification and characterization of GFRalpha-3, a novel Co-receptor belonging to the glial cell line-derived neurotrophic receptor family.	GFRA2 GFRA3	7.41e-05	4	123	2	9452475
Pubmed	The polycomb repressive complex 2 is a potential target of SUMO modifications.	EZH2 PIAS2	7.41e-05	4	123	2	18628979
Pubmed	Histone acetyltransferase 1 promotes gemcitabine resistance by regulating the PVT1/EZH2 complex in pancreatic cancer.	UBR4 EZH2	7.41e-05	4	123	2	34564701
Pubmed	Exome sequencing in seven families and gene-based association studies indicate genetic heterogeneity and suggest possible candidates for fibromuscular dysplasia.	MYLK RNF213	7.41e-05	4	123	2	26147384
Pubmed	Assay and functional properties of PrBP(PDEdelta), a prenyl-binding protein interacting with multiple partners.	GRK7 GRK1	7.41e-05	4	123	2	16473576
Pubmed	Investigation of germline GFRA4 mutations and evaluation of the involvement of GFRA1, GFRA2, GFRA3, and GFRA4 sequence variants in Hirschsprung disease.	GFRA2 GFRA3	7.41e-05	4	123	2	12624147
Pubmed	Human protein phosphatase PP6 regulatory subunits provide Sit4-dependent and rapamycin-sensitive sap function in Saccharomyces cerevisiae.	PPP6C PPP6R2	7.41e-05	4	123	2	19621075
Pubmed	GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family.	GFRA2 GFRA3	7.41e-05	4	123	2	9576965
Pubmed	HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.	CLTCL1 CLTC	7.41e-05	4	123	2	11517213
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	ZFYVE16 RPN2 USP11 SPTLC1 NME2P1 CHST9 YWHAB FBXO3 PPP6C ANAPC2 CLTC RPS19BP1 PPP6R2 DDX24 ANAPC5	7.73e-05	1335	123	15	29229926
Pubmed	Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome.	GALNT15 GALNT17 GALNT11	8.27e-05	24	123	3	31882545
Pubmed	A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.	ANAPC2 ACIN1 ANAPC5	8.27e-05	24	123	3	33705438
Pubmed	Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.	GALNT15 GALNT17 GALNT11	8.27e-05	24	123	3	31740596
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	USP11 UBR4 BMS1 YWHAB S100A8 ZC3H7A PPP6C CLTC ACIN1 MACF1 AFDN PARD3 FHL2 DDX24 NEXN	8.97e-05	1353	123	15	29467282
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	ERCC5 RPN2 UBR4 SPTLC1 PPP6C CLTC PPP6R2 DDX24	9.14e-05	399	123	8	37536630
Pubmed	Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.	SHROOM3 YWHAB GRK1 CASK PPP6C DHCR24 ANAPC2 CLTC	9.46e-05	401	123	8	25852190
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	CLTCL1 USP11 UBR4 CASK CEP350 S100A8 PPP6C ANAPC2 PPP6R2 DDX24	9.55e-05	639	123	10	23443559
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ERCC5 SCAF8 EZH2 MYO3A CLTC EXO1 ACIN1 AFDN PARD3 DDX24 ANAPC5	9.96e-05	774	123	11	15302935
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	RASGRF2 RPN2 SPTLC1 ALS2 ARID3B CASK S100A8 PPP6C ARHGEF7 RPS19BP1 SCP2 FGD5	1.03e-04	916	123	12	32203420
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	SHROOM3 BMS1 RNF213 CTDSP2 ARID3B CASK CEP350 CLTC ADAMTS16 AFDN PARD3	1.03e-04	777	123	11	35844135
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	RPN2 USP11 UBR4 BMS1 S100A8 CLTC ACIN1 MACF1 AFDN DDX24	1.14e-04	653	123	10	22586326
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	ZFYVE16 ITK ARHGEF7 AFDN PARD3	1.14e-04	133	123	5	15144186
Pubmed	A Japanese-specific allele in the GALNT11 gene.	GALNT11 CEP152	1.23e-04	5	123	2	20547088
Pubmed	GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family.	GFRA2 GFRA3	1.23e-04	5	123	2	9407096
Pubmed	Expression of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase isoforms in murine tissues determined by real-time PCR: a new view of a large family.	GALNT15 GALNT11	1.23e-04	5	123	2	12651884
Pubmed	Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.	CLTCL1 CLTC	1.23e-04	5	123	2	10436022
Pubmed	14-3-3 Proteins regulate exonuclease 1-dependent processing of stalled replication forks.	YWHAB EXO1	1.23e-04	5	123	2	21533173
Pubmed	During embryogenesis, esrp1 expression is restricted to a subset of epithelial cells and is associated with splicing of a number of developmentally important genes.	ESRP1 CASK	1.23e-04	5	123	2	23233200
Pubmed	Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins.	AFDN PARD3	1.23e-04	5	123	2	35283834
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	ERCC5 RPN2 KRT33A SCAF8 UBR4 POLR2I YWHAB DNAJC2 FBXO3 ARHGEF7 DHCR24 CLTC MACF1 FHL2 DDX24	1.47e-04	1415	123	15	28515276
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	USP11 RNF213 CEP350 MACF1	1.57e-04	76	123	4	27542412
Pubmed	Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.	RASGRF2 INPP5E YWHAB ARHGEF7 CLTC	1.82e-04	147	123	5	16959763
Pubmed	Vaginal epithelial cell-derived S100 alarmins induced by Candida albicans via pattern recognition receptor interactions are sufficient but not necessary for the acute neutrophil response during experimental vaginal candidiasis.	MRC1 S100A8	1.84e-04	6	123	2	24478092
Pubmed	Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.	YWHAB ACIN1	1.84e-04	6	123	2	19592491
Pubmed	A dynamic regulation of GDNF-family receptors correlates with a specific trophic dependency of cranial motor neuron subpopulations during development.	GFRA2 GFRA3	1.84e-04	6	123	2	10712625
Pubmed	Whn and mHa3 are components of the genetic hierarchy controlling hair follicle differentiation.	KRT33A KRT33B	1.84e-04	6	123	2	10559501
Pubmed	Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.	PPP6C PPP6R2	1.84e-04	6	123	2	20065038
Pubmed	Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils.	RIPOR2 YWHAB	1.84e-04	6	123	2	25588844
Pubmed	Expression and alternative splicing of mouse Gfra4 suggest roles in endocrine cell development.	GFRA2 GFRA3	1.84e-04	6	123	2	10860579
Pubmed	Genome-wide association study of personality traits in bipolar patients.	ITK PLCE1	1.84e-04	6	123	2	21368711
Pubmed	Neurturin mRNA expression suggests roles in trigeminal innervation of the first branchial arch and in tooth formation.	GFRA2 GFRA3	1.84e-04	6	123	2	9786421
Pubmed	Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere.	MYOM1 FHL2	1.84e-04	6	123	2	38569934
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	UBR4 CLTC KYAT3 MACF1 FHL2 NEXN	1.96e-04	235	123	6	28378594
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	RGPD2 RPN2 UBR4 RNF213 YWHAB S100A8 MYO3A FBXO3 CLTC MACF1 FHL2	2.11e-04	844	123	11	25963833
Pubmed	A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair.	CLTCL1 RPN2 YWHAB FBXO3 CLTC	2.20e-04	153	123	5	27462432
Pubmed	Systematic Affinity Purification Coupled to Mass Spectrometry Identified p62 as Part of the Cannabinoid Receptor CB2 Interactome.	RPN2 SPTLC1 S100A8 DHCR24	2.31e-04	84	123	4	31616248
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	RPN2 KRT33B USP11 POLR2I BMS1 YWHAB CASK S100A8 FBXO3 PPP6R2 DDX24 WDTC1	2.42e-04	1005	123	12	19615732
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	SHROOM3 RPN2 USP11 UBR4 BMS1 SPTLC1 DNAJC2 CASK ZC3H7A PPP6C CLTC MACF1 PARD3 PPP6R2 DDX24	2.50e-04	1487	123	15	33957083
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	KNTC1 USP11 PIAS2 MST1 ZC3H7A SEPHS1 CLTC MACF1 PPP6R2	2.53e-04	588	123	9	38580884
Interaction	NRXN2 interactions	CASK MACF1 AFDN DDX24	6.30e-07	12	123	4	int:NRXN2
Interaction	RAP1GAP interactions	CLTCL1 EZH2 YWHAB MEX3A AFDN	1.46e-05	51	123	5	int:RAP1GAP
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNT15 GALNT17 GALNT11	1.08e-04	20	85	3	433
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RASGRF2 ALS2 ARHGEF7 FGD5	2.63e-04	66	85	4	722
GeneFamily	VPS9 domain containing	ALS2 ALS2CL	9.59e-04	10	85	2	928
GeneFamily	Anaphase promoting complex \|Tetratricopeptide repeat domain containing	ANAPC2 ANAPC5	1.92e-03	14	85	2	402
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RGPD2 IFIT3 ZC3H7A WDTC1	2.12e-03	115	85	4	769
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RASGRF2 ITK AFAP1L1 ARHGEF7 FGD5	2.87e-03	206	85	5	682
Coexpression	WANG_SMARCE1_TARGETS_UP	MYLK RASGRF2 GABBR2 DENND2B IFIT3 ATP10D CTDSP2 CASK FHL2 NEXN	1.23e-06	294	122	10	M1804
Coexpression	GSE21927_UNTREATED_VS_GMCSF_IL6_TREATED_BONE_MARROW_UP	PPP1R14C GFRA2 CTDSP2 ARID3B S100A8 MEX3A MACF1 FHL2	3.65e-06	194	122	8	M7554
Coexpression	GSE21360_PRIMARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN	RIPOR2 ZFYVE16 USP11 CTDSP2 CEP350 MST1 GALNT11 MACF1	4.25e-06	198	122	8	M7610
Coexpression	GSE17186_MEMORY_VS_NAIVE_BCELL_DN	RASGRF2 ALS2CL RGS1 DIPK2A SEPHS1 DIAPH2 SCP2 SESN2	4.57e-06	200	122	8	M7171
Coexpression	NAKAYA_PBMC_FLUMIST_AGE_18_50YO_3DY_DN	SCAF8 EZH2 DNAJC2 CTDSP2 ARID3B SLC25A36 FBXO3 PPP6C B3GNT2 PPP1R16B SESN2 DDX24 ZNF292	1.77e-05	680	122	13	M41089
Coexpression	GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP	KNTC1 LARP1B EZH2 RASGEF1B ASB2 FHL2 MCOLN3	1.78e-05	174	122	7	M333
Coexpression	GSE32986_GMCSF_VS_GMCSF_AND_CURDLAN_HIGHDOSE_STIM_DC_DN	MYOM1 USP11 PIK3CD B3GNT2 FHL2 MCOLN3 WDTC1	4.06e-05	198	122	7	M8624
Coexpression	GSE41867_NAIVE_VS_DAY6_LCMV_EFFECTOR_CD8_TCELL_DN	RIPOR2 ATP10D ITK PPP1R16B ASB2 MCOLN3 ZNF292	4.33e-05	200	122	7	M9463
Coexpression	GSE26030_TH1_VS_TH17_RESTIMULATED_DAY5_POST_POLARIZATION_DN	ZFYVE16 BMS1 YWHAB CTDSP2 DHCR24 SCP2 ANAPC5	4.33e-05	200	122	7	M8574
Coexpression	GSE3982_DC_VS_MAC_UP	ERCC5 UBR4 SLC25A36 GALNT11 ANAPC2 PPP1R16B FHL2	4.33e-05	200	122	7	M5458
Coexpression	CUI_TCF21_TARGETS_2_DN	SHROOM3 RIPOR2 ZFYVE16 DENND2B DIPK2A FBXO3 B3GNT2 ADAMTS16 DIAPH2 PPP1R16B KANK4 MACF1 FGD5 PLCE1	4.50e-05	854	122	14	M1533
Coexpression	CUI_TCF21_TARGETS_2_DN	SHROOM3 RIPOR2 ZFYVE16 DENND2B DIPK2A FBXO3 B3GNT2 ADAMTS16 DIAPH2 PPP1R16B KANK4 MACF1 FGD5 PLCE1	6.83e-05	888	122	14	MM1018
CoexpressionAtlas	kidney_adult_RenalCapsule_k-means-cluster#4_top-relative-expression-ranked_1000	MRC1 MYLK ABCA9 ATP10D DIAPH2 NEXN PLCE1	1.11e-05	136	118	7	gudmap_kidney_adult_RenalCapsule_k4_1000
CoexpressionAtlas	alpha beta T cells, T.8SP69+.Th, 4- 8+ TCRhi 69+, Thymus, avg-3	KNTC1 RIPOR2 RNF213 ALS2CL IFIT3 ITK MEX3A PIK3CD PPP1R16B MCOLN3	3.49e-05	362	118	10	GSM399385_500
CoexpressionAtlas	facebase_RNAseq_e14.5_palate_poster_nasal_Tgfbr2_WT_2500_K0	MRC1 MYLK MYOM1 ABCA9 GALNT17 PIK3CD FHL2	7.17e-05	182	118	7	facebase_RNAseq_e14.5_palate_poster_nasal_Tgfbr2_WT_2500_K0
CoexpressionAtlas	Myeloid Cells, MF.RP.Sp, F4/80hi CD11blo CD11c- autofluorescent, Spleen, avg-3	MRC1 RGS1 GFRA2 RASGEF1B ASB2	7.43e-05	78	118	5	GSM605853_100
CoexpressionAtlas	gamma delta T cells, Tgd.vg2+24ahi.e17.Th, TCRd+ Vg2+ CD24+, Fetal Thymus, avg-3	KNTC1 MRC1 USP11 ALS2 EZH2 ITK MEX3A DHCR24 EXO1 MCOLN3	1.07e-04	414	118	10	GSM476660_500
CoexpressionAtlas	gamma delta T cells, Tgd.vg2-24ahi.Th, TCRd+ Vg2- CD24+, Thymus, avg-2	KNTC1 USP11 ALS2 EZH2 ITK DIPK2A MEX3A PPP1R16B EXO1 MCOLN3	1.25e-04	422	118	10	GSM476658_500
CoexpressionAtlas	gamma delta T cells, Tgd.vg2+24ahi.Th, TCRd+ Vg2+ CD24+, Thymus, avg-3	KNTC1 USP11 ALS2 EZH2 ITK DIPK2A MEX3A PPP1R16B MCOLN3 WDTC1	1.27e-04	423	118	10	GSM476655_500
CoexpressionAtlas	DevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_k-means-cluster#1_top-relative-expression-ranked_100	MYLK MYOM1 GFRA2 NEXN	1.34e-04	47	118	4	gudmap_developingKidney_e15.5_Ureteral Smooth Musc_100_k1
CoexpressionAtlas	kidney_adult_Mesangium_Meis_top-relative-expression-ranked_500	MRC1 MYOM1 IFIT3 ABCA9 ATP10D ZC3H7A B3GNT2 KANK4 FHL2 NEXN	1.43e-04	429	118	10	gudmap_kidney_adult_Mesangium_Meis_500
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 NTRK3 CSMD3 RASD1 FHL2 NEXN PLCE1	4.81e-08	188	121	8	d1a4cd4db95d8d32b79156290f7867f32824cc87
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 NTRK3 CLSTN2 RASD1 FHL2 NEXN PLCE1	5.22e-08	190	121	8	1803b1e7c36285f9eaabc3c6e9a9752c5908db3d
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RNF213 IFIT3 CEP350 RASGEF1B ACIN1 MACF1 DDX24 ZNF292	7.76e-08	200	121	8	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	COVID-19-kidney-PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GALNT15 RASGRF2 AFAP1L1 ARHGEF7 PPP1R16B MACF1 FGD5	6.28e-07	180	121	7	493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCell	droplet-Kidney-nan-18m-Epithelial-Stroma____kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 NTRK3 CLSTN2 CSMD3 NEXN PLCE1	6.28e-07	180	121	7	b6f44fdedc33b7d93b0074e8e9c8cc32009d4c4d
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 DENND2B GFRA2 ARHGEF7 NEXN PLCE1	6.76e-07	182	121	7	ffe500d78a89dc6b4d05bab1664e7f30c94fb8d9
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 DENND2B GFRA2 ARHGEF7 NEXN PLCE1	7.27e-07	184	121	7	94748f63947db79a6b4540e3090a63689fdd9452
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 DENND2B GFRA2 ARHGEF7 NEXN PLCE1	7.27e-07	184	121	7	819b277ecced7b415e363c7e7ddbc6f3b2d296de
ToppCell	IPF-Lymphoid-T_Regulatory\|World / Disease state, Lineage and Cell class	RIPOR2 RGS1 ITK CASK ZC3H7A PPP1R16B ZNF292	7.54e-07	185	121	7	77fbecdab10bacc005b1c7e22ca414cfecef13c1
ToppCell	droplet-Kidney-nan-21m-Epithelial-Stroma____kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 NTRK3 CLSTN2 RASD1 FHL2 NEXN	9.02e-07	190	121	7	e04f47705851563515b6a66a2634cf7a574f7bda
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Stroma____kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 NTRK3 RASD1 FHL2 NEXN PLCE1	9.34e-07	191	121	7	8597a8af294f24496c317d995f07eb5dcc25c13c
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 DENND2B RASD1 ASB2 NEXN PLCE1	1.00e-06	193	121	7	18e11d515147accef9aee26e934b358b445e18e2
ToppCell	10x5'-blood\|World / Manually curated celltypes from each tissue	LST1 RIPOR2 MYLK RNF213 YWHAB S100A8 SPDYC	1.00e-06	193	121	7	359d4242a7e5e51a3eaf6fe51bc1c653a402b054
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 DENND2B RASD1 ASB2 NEXN PLCE1	1.00e-06	193	121	7	7766f495f2f945802ef9a5b994cd00bb64d0dfe3
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 DENND2B RASD1 ASB2 NEXN PLCE1	1.00e-06	193	121	7	ce3e8cf30b7b4d5c7a8f3d64c21d81d2c3cab5c1
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 GFRA2 RASD1 ASB2 NEXN PLCE1	1.04e-06	194	121	7	3bff2e4eb16719ab7419b2f94c9c6e7302aa6629
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 NTRK3 RASD1 FHL2 NEXN PLCE1	1.04e-06	194	121	7	80be44e9ddd9f6ddd9dff7cba0eb457431204c2d
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 GFRA2 RASD1 ASB2 NEXN PLCE1	1.04e-06	194	121	7	fdaf61cbe7f77ff5358d150b38adb1fe3778e961
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 DENND2B ARHGEF7 ASB2 NEXN PLCE1	1.11e-06	196	121	7	184104cbea0461dd2757668ab9755948ac7b585a
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 DENND2B ARHGEF7 ASB2 NEXN PLCE1	1.11e-06	196	121	7	bebb20dc210576101c317011e3afb59798f5d255
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 DENND2B ARHGEF7 ASB2 NEXN PLCE1	1.11e-06	196	121	7	8114e98923096c54b6834f21550c3061bab6773d
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	RASGRF2 NTRK3 KHNYN CAPN6 KANK4 RASD1 PARD3	1.23e-06	199	121	7	a13f4b8a039304e685464cc8879659824cad5a3e
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	MYLK MYOM1 NTRK3 ARHGEF7 ASB2 NEXN PLCE1	1.27e-06	200	121	7	a3a1e35934d676c39f917652e50c502cb2f613c1
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KNTC1 MYOM1 GAL3ST4 GFRA2 ASB2 ST18	5.62e-06	163	121	6	8dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KNTC1 MYOM1 GAL3ST4 GFRA2 ASB2 ST18	5.62e-06	163	121	6	fd243ca223079033be480a24817a399f281fa4d4
ToppCell	facs-Heart-LV-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LST1 RIPOR2 CSMD3 S100A8 CEP152 FHL2	6.02e-06	165	121	6	84eca6a0f5e996b6955ae79fa102af239098fe8f
ToppCell	facs-Heart-LV-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LST1 RIPOR2 CSMD3 S100A8 CEP152 FHL2	6.02e-06	165	121	6	af59a095ecc6758abc13d763c00e44447c488167
ToppCell	facs-Skin-Skin_Anagen-18m-Lymphocytic-T_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIPOR2 RGS1 ITK PIK3CD PPP1R16B FGD5	6.91e-06	169	121	6	630d921aa8fb5681d06a4e09b833855c374be484
ToppCell	facs-Skin-Skin_Anagen-18m-Lymphocytic-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIPOR2 RGS1 ITK PIK3CD PPP1R16B FGD5	6.91e-06	169	121	6	468284d4a3a0557aed04eadb1aba2317babc6904
ToppCell	facs-Skin-Skin_Anagen-18m-Lymphocytic\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIPOR2 RGS1 ITK PIK3CD PPP1R16B FGD5	6.91e-06	169	121	6	6f765e142d127545e622fe24b5287cd6e9706ccc
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CERKL RASGRF2 FAM110D LRRC3B PPP1R16B FGD5	7.90e-06	173	121	6	a2c1ef3f4d7e9f68fc77ee7c42a4727bdea5da94
ToppCell	droplet-Lung-nan-21m-Myeloid-Interstitial_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 MYOM1 RGS1 ABCA9 RASGEF1B ASB2	7.90e-06	173	121	6	31ea04e65876c42b90245d280f0b6439bfffbace
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Endothelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CERKL RASGRF2 FAM110D LRRC3B PPP1R16B FGD5	7.90e-06	173	121	6	4830136f1f1976e00ac9af9062a531ac42533041
ToppCell	droplet-Lung-nan-21m-Myeloid-lung_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 MYOM1 RGS1 ABCA9 RASGEF1B ASB2	7.90e-06	173	121	6	1cff815536f620e32b9805666e1aa711462c2d25
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Endothelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CERKL RASGRF2 FAM110D LRRC3B PPP1R16B FGD5	7.90e-06	173	121	6	0b79e2a4fd19d524c24b69a6b524ffc6affdabe5
ToppCell	facs-Skin-Telogen-3m-Lymphocytic-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIPOR2 MYLK RGS1 ITK PIK3CD PPP1R16B	8.71e-06	176	121	6	3d372c1d527fcc118d1e5809f2524fc387682472
ToppCell	facs-Skin-Telogen-3m-Lymphocytic\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIPOR2 MYLK RGS1 ITK PIK3CD PPP1R16B	8.71e-06	176	121	6	7b3f3d9b33770edf294cee0eccaf8a46f9331461
ToppCell	facs-Skin-Telogen-3m-Lymphocytic-T_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIPOR2 MYLK RGS1 ITK PIK3CD PPP1R16B	8.71e-06	176	121	6	9c0fb2c6ae84febdf7c3d4e648985f597dcffe7a
ToppCell	droplet-Bladder-BLADDER-1m-Epithelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP1R14C GFRA2 GFRA3 GALNT17 KANK4 PLCE1	9.59e-06	179	121	6	c7c74e26bbf86c5326ee38bac7de111d5414f46b
ToppCell	E15.5-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MYLK GFRA2 MYO3A RASGEF1B MACF1 NEXN	9.59e-06	179	121	6	b559f5a72cc9e3e35d05cb539b5c2e006e56e652
ToppCell	5'-GW_trimst-2-LymphNode-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYOM1 PPP1R14C NTRK3 MYO3A B3GNT2 KANK4	1.02e-05	181	121	6	59527ad218e49386b04cabb97d53d2ed55a35961
ToppCell	facs-Thymus-Epithelium-3m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT15 MYLK FAM110D AFAP1L1 AFDN FGD5	1.02e-05	181	121	6	bce56e12ab93693c9c04fa6aad8f2e1dff0c4d45
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LST1 RNF213 RGS1 ITK PIK3CD PPP1R16B	1.05e-05	182	121	6	09d0793245d3d77ab5fc384c0b62637f736da50b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RASGRF2 FAM110D AFAP1L1 PPP1R16B EXO1 FGD5	1.12e-05	184	121	6	688428103e8b19f45f2f65d70a0f30c904c8411c
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 NTRK3 DHCR24 RASD1 ASB2	1.16e-05	185	121	6	30df02fbe2828e3c4f3e5c4cda855e74fb31be39
ToppCell	IPF-Lymphoid-T_Regulatory\|IPF / Disease state, Lineage and Cell class	RIPOR2 RGS1 ITK CASK PPP1R16B ZNF292	1.16e-05	185	121	6	221cbd09d94cc0947d0e3c1aa14716d17cb2068d
ToppCell	cellseq-Epithelial-Epithelial_Glandular-MEC-MEC\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GALNT15 MYLK CAPN6 KANK4 FHL2 NEXN	1.16e-05	185	121	6	76304829fcfb5934188933ca20d33bc8c8b0dc91
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	KNTC1 RNF213 DIPK2A CLTC MACF1 ZNF292	1.16e-05	185	121	6	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	COPD-Lymphoid-T_Regulatory\|COPD / Disease state, Lineage and Cell class	RGS1 ITK CASK ZC3H7A PPP1R16B ZNF292	1.16e-05	185	121	6	846403edd4c8f646201d519055198fc38b7ffff9
ToppCell	cellseq-Epithelial-Epithelial_Glandular-MEC\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GALNT15 MYLK CAPN6 KANK4 FHL2 NEXN	1.16e-05	185	121	6	0595e7ab37eed690f6e3d16a9a4e9a4bce2b89db
ToppCell	15-Distal-Immune-Hematopoietic,_T_Cells\|Distal / Age, Tissue, Lineage and Cell class	LST1 RIPOR2 RGS1 ITK PIK3CD RGL4	1.16e-05	185	121	6	481e3d3b63f2e5b4783088523c3cf70a461aed27
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RIPOR2 PPP1R14C CHST9 DHCR24 RASD1 FHL2	1.19e-05	186	121	6	3dae539cce15fcf2b1b32e981d7febe94c03c600
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	KNTC1 RNF213 DIPK2A CLTC MACF1 ZNF292	1.19e-05	186	121	6	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	droplet-Heart-HEART-1m-Neuronal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTRK3 GFRA2 GFRA3 GALNT17 DHCR24 DNAH11	1.19e-05	186	121	6	fddc6b93f98b10aaf8d4ebc142b46d8213f3129d
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 NTRK3 DHCR24 RASD1 ASB2	1.23e-05	187	121	6	8ff9f771d10c372d771c92dfa9006aa81aec4681
ToppCell	droplet-Fat-SCAT-30m-Endothelial-Cd36+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF2 FAM110D AFAP1L1 LRRC3B AFDN FGD5	1.27e-05	188	121	6	e901a9bdf00b8e91806f445af66647373bf62661
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYLK MYOM1 NTRK3 ASB2 NEXN PLCE1	1.27e-05	188	121	6	b2d68a32314e9b099ed74d974079ad96359d1ae3
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RIPOR2 RASGRF2 ITK CASK PIK3CD PPP1R16B	1.31e-05	189	121	6	df30478b288084a1bd48f660409dcc784040897c
ToppCell	droplet-Kidney-nan-3m-Epithelial-Stroma____kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 NTRK3 CLSTN2 FHL2 NEXN	1.31e-05	189	121	6	a959c9d6a0866582688a4204d625c1e5a123e93d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYOM1 NTRK3 MYO3A ASB2 NEXN PLCE1	1.31e-05	189	121	6	127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RIPOR2 PPP1R14C CHST9 DHCR24 RASD1 DNAH11	1.31e-05	189	121	6	1ecf9911ff82e0ca0f0c101b735d3b1f3b339d57
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYOM1 NTRK3 MYO3A ASB2 NEXN PLCE1	1.31e-05	189	121	6	2cfb4d12f75678d1619f4743838a0e954bd57761
ToppCell	Control-T_cells-CD4+_T_cells\|Control / group, cell type (main and fine annotations)	RIPOR2 RASGRF2 ITK CASK PIK3CD PPP1R16B	1.35e-05	190	121	6	0733be5e54fe15d6d6ea51c154a95258e83f1b92
ToppCell	Mesenchymal_cells-Smooth_muscle\|World / Lineage and Cell class	MYLK MYOM1 RASD1 ASB2 NEXN PLCE1	1.35e-05	190	121	6	5aa62a363a25f4a110136263b21289a11e8c1e6d
ToppCell	(0)_Normal/No_Treatment-(1)_VE-Cad+_vascular_cells\|World / Stress and Cell class	MRC1 FAM110D ARHGEF7 RASGEF1B DIAPH2 RASD1	1.35e-05	190	121	6	ff083168d609957d00888f31b3488d6d56c902b4
ToppCell	facs-SCAT-Fat-3m-Endothelial-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM110D AFAP1L1 LRRC3B RASD1 AFDN FGD5	1.39e-05	191	121	6	a0018f88f7132477cc467ee15db029a585290595
ToppCell	367C-Epithelial_cells\|367C / Donor, Lineage, Cell class and subclass (all cells)	SHROOM3 PPP1R14C ESRP1 CHST9 DHCR24 DNAH11	1.39e-05	191	121	6	d31975fc33779b0b3ff1a50d7c64fec8d08be4d4
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	KNTC1 RNF213 ITK DIPK2A MACF1 ZNF292	1.39e-05	191	121	6	9454f642c3621370fa23640b631301346b300950
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RIPOR2 MYOM1 NTRK3 B3GNT2 RASD1 DNAH11	1.39e-05	191	121	6	239c1e68eb1cbe3e137a99fbd6eeb8d64c919ffd
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 GFRA2 ASB2 NEXN PLCE1	1.39e-05	191	121	6	96ff4cfbdcaec4b8568f9482d732dddd399121d3
ToppCell	COVID-19-kidney-VWF+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GALNT15 RASGRF2 AFAP1L1 ARHGEF7 PPP1R16B FGD5	1.39e-05	191	121	6	2f00d0b7b2ffce8eb3eb5bbae49a0d425b23c982
ToppCell	facs-SCAT-Fat-3m-Endothelial-endothelial_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM110D AFAP1L1 LRRC3B RASD1 AFDN FGD5	1.39e-05	191	121	6	6b9bbf4a63d4e9a8075bb06c2aa644fcf4ee88b8
ToppCell	facs-SCAT-Fat-3m-Endothelial\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM110D AFAP1L1 LRRC3B RASD1 AFDN FGD5	1.39e-05	191	121	6	90f0c193dce267a4f1a9b2501f636dafd0a34cf7
ToppCell	COVID-19-T_cells-CD4+_T_cells\|COVID-19 / group, cell type (main and fine annotations)	RIPOR2 RASGRF2 ITK CASK PIK3CD PPP1R16B	1.39e-05	191	121	6	0646cca78e24aeb6baa9934d3c439b797c567997
ToppCell	10x3'2.3-week_14-16-Endothelial-stroma-immature_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	GALNT15 GAL3ST4 ALS2CL AFAP1L1 PPP1R16B FGD5	1.43e-05	192	121	6	5af3b2b38495e925497c48f605d618bbf970965d
ToppCell	droplet-Trachea-nan-3m-Mesenchymal-smooth_muscle_cell_of_trachea\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK MYOM1 ARHGEF7 RASD1 ASB2 NEXN	1.43e-05	192	121	6	a804cb101c3a5585f72217e1143584b1ca436724
ToppCell	NS-control-d_0-4-Lymphoid-Treg\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	RGS1 ITK PIK3CD PPP1R16B ASB2 RGL4	1.43e-05	192	121	6	ef252dd9df161f665f53c047c0514381f80d6683
ToppCell	(1)_Control_(PBS)-(1)_VE-Cad+_vascular_cells\|(1)_Control_(PBS) / Stress and Cell class	MRC1 FAM110D ARHGEF7 CLTC DIAPH2 FGD5	1.43e-05	192	121	6	e16e49b302019474232ef4cc0ff217d33afe34cf
ToppCell	control-Lymphoid-Treg\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RGS1 ITK PIK3CD PPP1R16B ASB2 RGL4	1.43e-05	192	121	6	9067e90b7c2d734100d6e5026d753113bf9428a3
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYLK MYOM1 ARHGEF7 RASD1 ASB2 NEXN	1.47e-05	193	121	6	d0dcc0c11ccf99ff6b07e456d25b9742649aadd8
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RGS1 ABCA9 CEP350 S100A8 CLTC MACF1	1.47e-05	193	121	6	06b65110db974f4ef90d3511ff34428976a52c9c
ToppCell	(4)_Endothelial_cells\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	MRC1 FAM110D AFAP1L1 RASGEF1B PPP1R16B FGD5	1.47e-05	193	121	6	ae6ba13d4d9f2a700887cdda2790c32007b29ac8
ToppCell	droplet-Bladder-BLADDER-1m-Endothelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF2 FAM110D AFAP1L1 LRRC3B PPP1R16B FGD5	1.47e-05	193	121	6	3a5090f81f35026f435f4a250d1e77601a53af15
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RGS1 ABCA9 CEP350 S100A8 CLTC MACF1	1.47e-05	193	121	6	9c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYLK MYOM1 NTRK3 CLSTN2 DIPK2A NEXN	1.47e-05	193	121	6	88916d9a7d831eb52848599917c04238f8f9812b
ToppCell	facs-Brain_Myeloid-Hippocampus-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RGS1 ABCA9 CEP350 S100A8 CLTC MACF1	1.47e-05	193	121	6	a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCell	droplet-Bladder-nan-3m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF2 FAM110D AFAP1L1 PPP1R16B RASD1 FGD5	1.47e-05	193	121	6	8be24713f8ba2545b7647d1994e9e993623ddaa3
ToppCell	facs-MAT-Fat-3m-Endothelial\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM110D AFAP1L1 LRRC3B RASD1 AFDN FGD5	1.47e-05	193	121	6	b32533afeff1905e188becaa09079e9699722e4b
ToppCell	mild_COVID-19_(asymptomatic)-CD4+_Tcm\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	RASGRF2 RGS1 ITK CASK PPP1R16B DDX24	1.47e-05	193	121	6	498d3a83bce6deff69aea71b18a43688e0a8ed7d
ToppCell	droplet-Bladder-nan-3m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF2 FAM110D AFAP1L1 PPP1R16B RASD1 FGD5	1.47e-05	193	121	6	19dfc4a2c91fcea4f5991e7c44df46faeecb06b8
ToppCell	droplet-Bladder-BLADDER-1m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF2 FAM110D AFAP1L1 LRRC3B PPP1R16B FGD5	1.47e-05	193	121	6	13731b7fc1e3bec0cebc44bad7e2ecea358bb76a
ToppCell	droplet-Bladder-nan-3m-Endothelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF2 FAM110D AFAP1L1 PPP1R16B RASD1 FGD5	1.47e-05	193	121	6	351e0acd411a9eb0dbc0e358d0d1e3759753fa40
ToppCell	facs-MAT-Fat-3m-Endothelial-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM110D AFAP1L1 LRRC3B RASD1 AFDN FGD5	1.47e-05	193	121	6	2ff573ba2c74583ed1cb071a3bbc01bb71117e5f
ToppCell	PCW_05-06-Epithelial-Epithelial_proliferating\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	PPP1R14C CAPN6 ESRP1 CHST9 MYO3A DHCR24	1.47e-05	193	121	6	5f0eba7b1440beb891d94a288f7f18a4e13c3a88
ToppCell	droplet-Bladder-BLADDER-1m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF2 FAM110D AFAP1L1 LRRC3B PPP1R16B FGD5	1.47e-05	193	121	6	88cd7d0d0da5c776b49fc131f746fe5ad9676fb7
ToppCell	facs-MAT-Fat-3m-Endothelial-endothelial_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM110D AFAP1L1 LRRC3B RASD1 AFDN FGD5	1.47e-05	193	121	6	e164f6403a8b541ced08a6feec915d2e855036ea
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RGS1 ABCA9 CEP350 S100A8 CLTC MACF1	1.47e-05	193	121	6	b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LST1 MRC1 RGS1 ITK PIK3CD ST18	1.51e-05	194	121	6	96f16bcd393a0d3f8df479b172b5360ae5a1e663
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RIPOR2 RASGRF2 ITK CASK PIK3CD PPP1R16B	1.51e-05	194	121	6	3d6f2d190dd50804afea299957cc44c2bb756134
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYOM1 NTRK3 MYO3A ASB2 NEXN PLCE1	1.51e-05	194	121	6	5c3b2b05d1e4f146551fe4c920263d8e6ca34de3
Disease	amyotrophic lateral sclerosis type 2 (implicated_via_orthology)	ALS2 ALS2CL	1.61e-05	2	119	2	DOID:0060194 (implicated_via_orthology)
Disease	response to TNF antagonist, joint damage measurement	GABBR2 CSMD3 GFRA2	1.38e-04	25	119	3	EFO_0004653, EFO_0005413
Disease	thiosulfate sulfurtransferase measurement	CTDSP2 SCP2	2.39e-04	6	119	2	EFO_0802130
Disease	peripheral neuropathy	NTRK3 GALNT17	3.34e-04	7	119	2	EFO_0003100
Disease	Malignant neoplasm of breast	RASGRF2 UBR4 SPTLC1 EZH2 ALS2CL MST1 LRRC3B EXO1 SCP2 MACF1 FGD5 FHL2 ANAPC5	4.04e-04	1074	119	13	C0006142
Disease	Colorectal Carcinoma	RASGRF2 CAPN6 CLSTN2 CSMD3 ABCA9 LRRC3B EXO1 ACIN1 SESN2 ZNF292	5.66e-04	702	119	10	C0009402
Disease	plexin-B2 measurement	MRC1 PPP6R2	5.70e-04	9	119	2	EFO_0021867
Disease	phenylacetylglutamine measurement	CTDSP2 SCP2	1.04e-03	12	119	2	EFO_0021013
Disease	serum gamma-glutamyl transferase measurement	LRRC75B CSMD3 DENND2B ITK S100A8 PARD3 PPP6R2 ANAPC5 PIWIL3 ZNF292 PLCE1	1.20e-03	914	119	11	EFO_0004532
Disease	Diffuse Large B-Cell Lymphoma	EZH2 PIK3CD CLTC	1.44e-03	55	119	3	C0079744
Disease	migraine disorder, systolic blood pressure	RNF213 PLCE1	2.37e-03	18	119	2	EFO_0006335, MONDO_0005277
Disease	hemifacial microsomia	SHROOM3 ARID3B	2.64e-03	19	119	2	MONDO_0015398
Disease	serum albumin measurement	MRC1 SHROOM3 LARP1B YWHAB ABCA9 GFRA2 MACF1 ASB2	2.81e-03	592	119	8	EFO_0004535
Disease	renal system measurement	SHROOM3 SCAF8	2.92e-03	20	119	2	EFO_0004742
Disease	stomach cancer (is_implicated_in)	ERCC5 NTRK3 EZH2	3.11e-03	72	119	3	DOID:10534 (is_implicated_in)
Disease	Bronchiectasis	PIK3CD DNAH11	3.53e-03	22	119	2	C0006267
Disease	diet measurement, fasting blood insulin measurement	CLSTN2 ARHGEF7	3.53e-03	22	119	2	EFO_0004466, EFO_0008111
Disease	glaucoma	RIPOR2 SPTLC1 ST18 PLCE1	3.56e-03	154	119	4	MONDO_0005041
Disease	diet measurement, HOMA-IR	CLSTN2 ARHGEF7	3.86e-03	23	119	2	EFO_0004501, EFO_0008111

Protein segments in the cluster

Peptide	Gene	Start	Entry
LDDLFRKTKAAPCIY	ACIN1	1211	Q9UKV3
GLEKENPKDYCIARV	AFDN	286	P55196
RLLPQASEDKFDCYK	ALS2CL	396	Q60I27
AYECEKKALSSPAEL	ARID3B	301	Q8IVW6
YEILNSPEKACSLAK	YWHAB	181	P31946
DSNERLGLKVYKCNP	CEP152	1526	O94986
VPEDIRAALEAYCKK	ANAPC2	611	Q9UJX6
LEYKAKLRESCFDPG	CSMD3	1691	Q7Z407
DDIRKYLIKACDTPL	ALS2	1366	Q96Q42
ETPLYKACERKNAEA	ASB2	206	Q96Q27
TNKFPELYRDLDRCS	ABCA9	756	Q8IUA7
TCRPNLYEKLKDLQS	DNAH11	1591	Q96DT5
LRPSAALCYKEDLSK	ARHGEF7	661	Q14155
ADICEEKYRDILKFP	DIAPH2	881	O60879
LRAKSPIDCELQKEY	CLSTN2	106	Q9H4D0
YLDRSPSACKRDAQK	DENND2B	101	P78524
RCLNEKEKLVYAPLS	BMS1	326	Q14692
DNAYSCDPRIKKFKE	DNAJC2	271	Q99543
PKSALDEYRKRECRD	RPS19BP1	56	Q86WX3
AYACKLLEPDDKLFI	ATP10D	931	Q9P241
KEDLFILPDEYKSCL	ADAMTS16	261	Q8TE57
EASKKNVLLPECFYS	ESRP1	121	Q6NXG1
KSCLLLRFADDPYTE	RAB1C	21	Q92928
DDPQRCAYFEISAKK	RASD1	166	Q9Y272
LACEDYKKTESDLLP	RGS1	116	Q08116
SDLLPCKAEEIYKAF	RGS1	126	Q08116
RYEEQRPSLKEAKCL	NEXN	211	Q0ZGT2
ASYDQPKKAEALEAA	ANAPC5	676	Q9UJX4
ISCYPENNDAKELKR	CASK	416	O14936
SIEKALPEDRGLYKC	MYLK	1156	Q15746
LPEDRGLYKCVAKND	MYLK	1161	Q15746
KVDSDLADYKLRAQP	INPP5E	211	Q9NRR6
SECKDLPNSGKYRLE	MCOLN3	526	Q8TDD5
KVFLAECYNLSPTKD	NTRK3	551	Q16288
KNRSKYDDPCGLLKQ	LRRC53	546	A6NM62
NNKDLYLRPCDGKAR	GALNT15	611	Q8N3T1
YKRKNTETALDNKPC	EZH2	306	Q15910
KDALPEKACQLDSRY	FBXO3	316	Q9UK99
PGARAKDKITCDLYQ	FBXO46	296	Q6PJ61
CLSRALPEDYKAQAL	FGD5	1201	Q6ZNL6
TRNAACKEKFYPPDL	GALNT11	136	Q8NCW6
RDKLDHCLQEASPRY	GHDC	456	Q8N2G8
YRSLLESEDCKLPSN	KRT33A	356	O76009
VNLARDLQCPKKDYE	LRRC75B	91	Q2VPJ9
YLLEGVCKNDPKLSE	KNTC1	366	P50748
DADLCNLPKKTTDYA	LRRC3B	191	Q96PB8
KDPLDNDKSCYSERK	RASGEF1B	236	Q0VAM2
CERLATPELQYKDKL	GAL3ST4	451	Q96RP7
PYSECDFKLKEVARN	MACF1	2891	Q9UPN3
YFLKNKVSPDLCNED	PPP1R16B	86	Q96T49
LSDKESYKLSCQLEP	RGL4	456	Q8IZJ4
CSYEDKEKPNCLDLR	GFRA2	241	O00451
LNDKCDRLRKAYGEA	GFRA3	171	O60609
LAKYADPVTDLLDRC	CTDSP2	166	O14595
EALLDECANPKKRYG	DIPK2A	396	Q8NDZ4
DAFPEVYDKICKAAR	DHCR24	501	Q15392
KCYEKELGRLLRDAP	IFIT3	436	O14879
KALNEEKVAYDCSPN	REXO1L1P	321	Q8IX06
ILKEKEFCPGERNSY	CEP350	1011	Q5VT06
YGELRNNKAKDVCLD	GALNT17	466	Q6IS24
ERPAGDSKYDLLCKE	CERKL	76	Q49MI3
CRNSLVDKPFAAKED	FHL2	71	Q14192
QELDDKSATCKAYPK	DDX24	371	Q9GZR7
LRLYDTECDNAKGLK	GABBR2	101	O75899
KAERYKPSEEFLNAC	KANK4	741	Q5T7N3
AKEYLKGLCSPELQD	KHNYN	66	O15037
YDLFNRSVCDKKLPE	GCNA	526	Q96QF7
RFTPEKYACKDLREN	MST1	316	P26927
QASKDFCEALLEKDP	GRK1	421	Q15835
YLQARKPSDCDSKEL	GRK7	16	Q8WTQ7
DPSDCRDLKSLYLRK	CAPN6	601	Q9Y6Q1
CILPNDDKRRYDSIK	PIWIL3	581	Q7Z3Z3
FQNLYRCPGDDKSKI	SCAF8	96	Q9UPN6
ECYFNSLPKELEVKR	KYAT3	336	Q6YP21
EKVRFKYPNTACELL	PPP6R2	71	O75170
PKLQEYLCSFKRLED	LARP1B	831	Q659C4
CDRKKDENYRSLPRD	PARD3	191	Q8TEW0
PVCDKKAAYESLILD	PIAS2	386	O75928
KEDPRADYACIAENK	LST1	81	O00453
ASKLQEALVDCYKPT	PPP1R14C	126	Q8TAE6
LEKLATGCAQYDPTK	ITK	136	Q08881
ADEPKLKSACVYLDL	MRC1	1181	P22897
SECRAELKDYLRFAP	SESN2	6	P58004
LDAPVLTQAKCKASY	PRSS3P2	161	Q8NHM4
RDDLKKLLETECPQY	S100A8	31	P05109
VKPSLSCKDLALYEN	SPATA5L1	726	Q9BVQ7
KDLKDLFDVYAVPCN	PLCE1	1231	Q9P212
ELLCKNDVTDGRAKY	RGPD2	101	P0DJD1
KLLKQYEANPACEGR	RASGRF2	361	O14827
SLRFKPEELVDYKSC	NME2P1	116	O60361
GKPDLDKIREFCQRY	ERCC5	951	P28715
PKEDKENRILLYACR	POLR2I	26	P36954
EQAARFCAEIKSPKY	SEPHS1	331	P49903
LISELCKPNEFDKYR	SHROOM3	1821	Q8TF72
AYSNCKEKLNDVFDP	SLC25A36	101	Q96CQ1
RKCYEKSGLTPNDID	SCP2	286	P22307
PDSLIFYRQKRDCKA	FAM110D	81	Q8TAY7
ACAEKLAKGEPTDRY	EXO1	41	Q9UQ84
LAYEQLDKFPRDCVK	RIPOR2	1041	Q9Y4F9
LTQARYLEKEEKCLP	SPTLC1	426	O15269
SNLERDYSPECKALL	ST18	1021	O60284
DYSPECKALLESIKQ	ST18	1026	O60284
RNYSLLIDQPDKCAK	B3GNT2	126	Q9NY97
DQLLCYKSSKDRQPH	AFAP1L1	246	Q8TED9
SNCYDPERVKNFLKE	CLTC	751	Q00610
SSCYNPERVKNFLKE	CLTCL1	751	P53675
KSEARYLVCRKDPEL	CLTCL1	941	P53675
KKYRPNACEEALING	CHST9	311	Q7L1S5
KDQYLPRKLCDSARN	RNF213	1501	Q63HN8
YDALRDCLKAISLNP	WDTC1	416	Q8N5D0
PKNLDYKRDLFCLSV	MIS18A	156	Q9NYP9
EIARLCKYLPENDLK	PPP6C	11	O00743
PDAKKACTYIRSNLD	RPN2	66	P04844
SDAKLCALYKEAELR	MEX3A	111	A1L020
SKDPCFQISDKYLLA	SPDYC	76	Q5MJ68
CREPLVYDLASLKAA	RNF25	201	Q96BH1
KRSYCKPLDGAEIAQ	ZNF292	1396	O60281
LPELSCSKDIQYLKD	PIK3CD	986	O00329
KAYDAVAKCSLAVPQ	ZC3H7A	141	Q8IWR0
VIEPDKNRKYCSAKA	ZC3H7A	721	Q8IWR0
PYKREECDKAFNQSL	ZNF681	281	Q96N22
LIDKAIDTGENPYKC	ZNF611	331	Q8N823
KCRSINYDEKDPFLC	UBR4	3686	Q5T4S7
KKEYVELCDAAGRPD	USP11	421	P51784
KYVCNKISLLPNDED	ZFYVE16	1006	Q7Z3T8
YRSLLESEDCKLPSN	KRT33B	356	Q14525
APCYDKKLEALQESL	NARF	226	Q9UHQ1
CIKPNSERQARKYDK	MYO3A	951	Q8NEV4
AAPLDVKCLEANKDY	MYOM1	511	P52179