Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpoly(G) binding

HNRNPDL FMR1

1.18e-0410332GO:0034046
GeneOntologyBiologicalProcessmRNA metabolic process

HNRNPDL FMR1 RBMXL3 VIRMA CDK13 HNRNPAB RBM3 HNRNPD PKP3

7.26e-06917329GO:0016071
GeneOntologyBiologicalProcessestablishment of skin barrier

FLG HRNR FLG2

3.47e-0541323GO:0061436
GeneOntologyBiologicalProcessregulation of mRNA metabolic process

FMR1 RBMXL3 HNRNPAB RBM3 HNRNPD PKP3

5.35e-05443326GO:1903311
GeneOntologyBiologicalProcessskin epidermis development

FLG HRNR FLG2 PKP3

1.22e-04166324GO:0098773
GeneOntologyCellularComponentkeratohyalin granule

FLG HRNR FLG2

2.95e-085313GO:0036457
GeneOntologyCellularComponentcornified envelope

FLG HRNR FLG2 PKP3

3.20e-0669314GO:0001533
GeneOntologyCellularComponentneuronal ribonucleoprotein granule

FMR1 HNRNPAB

9.51e-0510312GO:0071598
GeneOntologyCellularComponentcytosolic region

KIF5C FMR1 HNRNPAB

1.51e-0470313GO:0099522
GeneOntologyCellularComponentneuron projection cytoplasm

KIF5C FMR1 HNRNPAB

5.72e-04110313GO:0120111
GeneOntologyCellularComponentcytoplasmic ribonucleoprotein granule

FLG FMR1 WTIP HNRNPAB

6.42e-04269314GO:0036464
GeneOntologyCellularComponentribonucleoprotein granule

FLG FMR1 WTIP HNRNPAB

8.17e-04287314GO:0035770
GeneOntologyCellularComponentcollagen-containing extracellular matrix

FLG COL22A1 HRNR FCN2 CDON

1.01e-03530315GO:0062023
GeneOntologyCellularComponentcytoplasmic region

KIF5C MARK2 FMR1 HNRNPAB

1.88e-03360314GO:0099568
GeneOntologyCellularComponentpostsynaptic cytosol

KIF5C FMR1

2.03e-0345312GO:0099524
GeneOntologyCellularComponentpresynaptic cytosol

FMR1 HNRNPAB

2.40e-0349312GO:0099523
GeneOntologyCellularComponentextracellular matrix

FLG COL22A1 HRNR FCN2 CDON

2.59e-03656315GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

FLG COL22A1 HRNR FCN2 CDON

2.62e-03658315GO:0030312
GeneOntologyCellularComponentpostsynapse

JAK2 KIF5C MARK2 FMR1 HNRNPAB HNRNPD

3.40e-031018316GO:0098794
GeneOntologyCellularComponentadherens junction

SHROOM3 WTIP PKP3

3.75e-03212313GO:0005912
MousePhenodecreased corpora lutea number

MARK2 HERC2 FMR1

3.00e-0533263MP:0002680
DomainCARG-binding_factor_N

HNRNPAB HNRNPD

3.03e-062332IPR012956
DomainFilaggrin

FLG FLG2

3.03e-062332IPR003303
DomainCBFNT

HNRNPAB HNRNPD

3.03e-062332PF08143
DomainS100_CABP

FLG HRNR FLG2

1.43e-0527333PS00303
DomainS_100

FLG HRNR FLG2

1.43e-0527333PF01023
DomainS100_Ca-bd_sub

FLG HRNR FLG2

1.60e-0528333IPR013787
DomainS100/CaBP-9k_CS

FLG HRNR FLG2

1.60e-0528333IPR001751
DomainS_100

FLG HRNR FLG2

1.60e-0528333SM01394
DomainRRM_1

HNRNPDL RBMXL3 HNRNPAB RBM3 HNRNPD

3.01e-05208335PF00076
DomainRRM

HNRNPDL RBMXL3 HNRNPAB RBM3 HNRNPD

3.68e-05217335SM00360
DomainRRM_dom

HNRNPDL RBMXL3 HNRNPAB RBM3 HNRNPD

4.56e-05227335IPR000504
DomainRRM

HNRNPDL RBMXL3 HNRNPAB RBM3 HNRNPD

4.86e-05230335PS50102
Domain-

HNRNPDL RBMXL3 HNRNPAB RBM3 HNRNPD

6.43e-052443353.30.70.330
DomainNucleotide-bd_a/b_plait

HNRNPDL RBMXL3 HNRNPAB RBM3 HNRNPD

8.37e-05258335IPR012677
DomainEF_Hand_1_Ca_BS

FLG HRNR FLG2

3.59e-03175333IPR018247
DomainEF_HAND_1

FLG HRNR FLG2

5.50e-03204333PS00018
DomainEF_HAND_2

FLG HRNR FLG2

7.75e-03231333PS50222
DomainEF_hand_dom

FLG HRNR FLG2

7.84e-03232333IPR002048
DomainCollagen

COL22A1 FCN2

9.86e-0385332PF01391
DomainCollagen

COL22A1 FCN2

9.86e-0385332IPR008160
Domain-

FLG HRNR FLG2

1.08e-022613331.10.238.10
DomainEF-hand-dom_pair

FLG HRNR FLG2

1.39e-02287333IPR011992
PathwayWP_MRNA_PROCESSING

HNRNPDL FMR1 RBMXL3 VIRMA HNRNPAB RBM3 HNRNPD

9.54e-06451257MM15946
PathwayREACTOME_ERYTHROPOIETIN_ACTIVATES_RAS

JAK2 RAPGEF1

1.35e-0410252MM15624
PathwayREACTOME_ERYTHROPOIETIN_ACTIVATES_RAS

JAK2 RAPGEF1

2.71e-0414252M27908
PathwayREACTOME_SIGNALING_BY_ERYTHROPOIETIN

JAK2 RAPGEF1

4.04e-0417252MM15584
Pubmed

Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.

FLG HRNR FLG2

8.54e-10334323403047
Pubmed

hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.

HNRNPDL FLG SHROOM3 MARK2 HRNR FLG2 HNRNPAB HNRNPD

1.28e-0934634825324306
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

HNRNPDL FLG SHROOM3 COL22A1 HRNR FMR1 HNRNPAB RBM3 HNRNPD

3.26e-0875434935906200
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

HNRNPDL FLG HRNR FMR1 FLG2 VIRMA HNRNPAB HNRNPD

9.76e-0860534828977666
Pubmed

DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.

FLG HRNR FLG2 HNRNPAB HNRNPD PKP3

1.10e-0723834635864588
Pubmed

Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop.

HNRNPDL HRNR FMR1 FLG2 HNRNPAB HNRNPD

1.86e-0726034636199071
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

HNRNPDL MARK2 HERC2 FMR1 VIRMA CDK13 HNRNPAB HNRNPD

5.45e-0775934835915203
Pubmed

A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons.

FMR1 HNRNPAB HNRNPD

5.75e-071734312388589
Pubmed

Atopic Dermatitis Susceptibility Variants in Filaggrin Hitchhike Hornerin Selective Sweep.

FLG HRNR

9.28e-07234227678121
Pubmed

Auto- and cross-regulation of the hnRNPs D and DL.

HNRNPDL HNRNPD

9.28e-07234229263134
Pubmed

Expression of filaggrin-2 protein in the epidermis of human skin diseases: a comparative analysis with filaggrin.

FLG FLG2

9.28e-07234224813994
Pubmed

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.

HNRNPDL FLG HRNR FMR1 FLG2 HNRNPAB HNRNPD

9.74e-0755834727591049
Pubmed

A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.

HNRNPDL FMR1 RBMXL3 HNRNPAB RBM3 HNRNPD

1.00e-0634734616033648
Pubmed

Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.

FLG HRNR FLG2

1.12e-062134319601998
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

HNRNPDL KIF5C HRNR RBMXL3 CDK13 HNRNPAB RBM3 HNRNPD PPIF

1.16e-06115334929845934
Pubmed

Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6.

HNRNPDL HNRNPAB RBM3 HNRNPD

1.83e-069034423151878
Pubmed

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.

MARK2 HRNR FLG2 VIRMA HNRNPAB HNRNPD

2.28e-0640034635013556
Pubmed

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

HNRNPDL JAK2 SHROOM3 FLG2 CDK13 PKP3

2.32e-0640134625852190
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

HNRNPDL MARK2 HRNR FMR1 FLG2 VIRMA HNRNPAB HNRNPD PKP3

2.37e-06125734936526897
Pubmed

GATA3 regulates FLG and FLG2 expression in human primary keratinocytes.

FLG FLG2

2.78e-06334228928464
Pubmed

Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.

FLG FLG2

2.78e-06334232437351
Pubmed

Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.

HNRNPAB RBM3 HNRNPD

3.40e-063034315782174
Pubmed

Interaction proteomics of the HMGA chromatin architectural factors.

HNRNPDL HNRNPAB HNRNPD

4.15e-063234318850631
Pubmed

Dendritic mRNA targeting of Jacob and N-methyl-d-aspartate-induced nuclear translocation after calpain-mediated proteolysis.

KIF5C FMR1

9.26e-06534219608740
Pubmed

Incomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse.

FMR1 RBM3

9.26e-06534221613321
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

HNRNPDL MARK2 HERC2 FMR1 FLG2 CDK13 HNRNPAB HNRNPD PPIF

9.73e-06149634932877691
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

HNRNPDL FMR1 VIRMA CDK13 HNRNPAB RBM3 HNRNPD

1.10e-0580734722681889
Pubmed

Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype.

FLG FLG2

1.39e-05634227304082
Pubmed

A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level.

SHROOM3 COL22A1

1.39e-05634220222955
Pubmed

Proteomic analysis of the cullin 4B interactome using proximity-dependent biotinylation in living cells.

HNRNPDL RBMXL3 RBM3 HNRNPD

1.51e-0515334428225217
Pubmed

The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome.

MARK2 HNRNPAB HNRNPD

1.72e-055134326269332
Pubmed

Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.

HNRNPDL HNRNPAB HNRNPD

1.83e-055234324591637
Pubmed

Shroom3 functions downstream of planar cell polarity to regulate myosin II distribution and cellular organization during neural tube closure.

DVL2 SHROOM3

1.94e-05734225596276
Pubmed

Suppression of apoptosis impairs phalangeal joint formation in the pathogenesis of brachydactyly type A1.

COL22A1 CDON

1.94e-05734238472182
Pubmed

The nuclear transcription factor RARalpha associates with neuronal RNA granules and suppresses translation.

HNRNPAB RBM3 HNRNPD

2.05e-055434318495661
Pubmed

IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.

HNRNPDL HNRNPAB HNRNPD

2.54e-055834321642987
Pubmed

Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins.

FMR1 PKP3

2.59e-05834225225333
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

SHROOM3 MARK2 HNRNPD PKP3

2.85e-0518034435198878
Pubmed

Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.

SHROOM3 HERC2 HRNR FMR1 FLG2 PKP3

2.91e-0562634633644029
Pubmed

A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.

HRNR FLG2 PKP3

3.10e-056234326644517
Pubmed

Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.

JAK2 HERC2

3.33e-05934226692333
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

DVL2 SHROOM3 KIF5C HERC2 FMR1 WTIP VIRMA

3.42e-0596334728671696
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

DVL2 HNRNPDL HNRNPAB RBM3 HNRNPD

4.10e-0539934535987950
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

MARK2 HERC2 FMR1 RBMXL3 FLG2 VIRMA CDK13 RBM3

4.15e-05137134836244648
Pubmed

PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.

HNRNPDL MARK2 CDK13 HNRNPAB RBM3 HNRNPD

4.53e-0567834630209976
Pubmed

Interactomic analysis of REST/NRSF and implications of its functional links with the transcription suppressor TRIM28 during neuronal differentiation.

COL22A1 HNRNPAB RBM3 HNRNPD

4.73e-0520534427976729
Pubmed

CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway.

FLG FMR1 FLG2

4.86e-057234336123327
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

HNRNPDL MARK2 HERC2 HRNR HNRNPAB HNRNPD PKP3

5.04e-05102434724711643
Pubmed

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.

HNRNPDL HRNR HNRNPAB RBM3 HNRNPD

5.84e-0543034538172120
Pubmed

A functional reference map of the RNF8 interactome in cancer.

FLG HRNR FLG2 HNRNPD

6.01e-0521834435831895
Pubmed

A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-of-origin effects.

FMR1 RBM3

6.08e-051234226511926
Pubmed

LncRNA SAMD12-AS1 promotes cell proliferation and inhibits apoptosis by interacting with NPM1.

FLG HRNR

6.08e-051234231406141
Pubmed

GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.

HRNR FMR1 FLG2 PKP3

6.56e-0522334433731348
Pubmed

Genetic variants associated with disordered eating.

FLG VSTM2B FLG2

7.43e-058334323568457
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

HRNR FMR1 FLG2 VIRMA

7.90e-0523434436243803
Pubmed

PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78.

FLG HRNR

8.38e-051434229178343
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

HNRNPDL MARK2 VIRMA CDK13 HNRNPD PKP3

9.41e-0577434615302935
Pubmed

SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.

FLG HRNR FMR1 FLG2

9.44e-0524534435652658
Pubmed

TRIM25 and DEAD-Box RNA Helicase DDX3X Cooperate to Regulate RIG-I-Mediated Antiviral Immunity.

FLG HRNR FLG2

9.78e-059134334445801
Pubmed

Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.

JAK2 HERC2

1.10e-041634219068216
Pubmed

TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination.

HRNR FLG2

1.10e-041634231823782
Pubmed

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.

HNRNPDL FMR1 HNRNPAB HNRNPD

1.15e-0425834437794589
Pubmed

Proteomic dissection of the von Hippel-Lindau (VHL) interactome.

HNRNPDL HNRNPAB HNRNPD

1.22e-049834321942715
Pubmed

Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.

SHROOM3 MARK2 PKP3

1.37e-0410234315778465
Pubmed

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.

MARK2 FMR1 HNRNPAB HNRNPD

1.45e-0427434434244482
Pubmed

Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA.

SHROOM3 HRNR FLG2

1.58e-0410734332989256
Pubmed

SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects.

DVL2 SHROOM3

1.74e-042034232511952
Pubmed

Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.

FMR1 VIRMA HNRNPD

1.91e-0411434331553912
Pubmed

Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma.

HNRNPDL HNRNPAB HNRNPD

1.96e-0411534320000738
Pubmed

Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis.

HNRNPDL HNRNPD PPIF

2.01e-0411634337117180
Pubmed

TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.

FLG FMR1 FLG2

2.06e-0411734336898370
Pubmed

Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs.

HNRNPAB HNRNPD

2.12e-042234212456657
Pubmed

Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins.

HNRNPDL HNRNPAB

2.12e-042234226420826
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

HNRNPDL FMR1 CDK13 HNRNPAB RBM3 HNRNPD PKP3

2.16e-04129434730804502
Pubmed

Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication.

HNRNPDL HNRNPAB HNRNPD

2.27e-0412134334029587
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

SHROOM3 MARK2 HNRNPAB HNRNPD PKP3

2.40e-0458234520467437
Pubmed

A MicroRNA Profile in Fmr1 Knockout Mice Reveals MicroRNA Expression Alterations with Possible Roles in Fragile X Syndrome.

KIF5C FMR1

2.74e-042534224906954
Pubmed

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.

MARK2 FMR1 CDK13 HNRNPAB HNRNPD PKP3

2.84e-0494934636574265
Pubmed

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

RAPGEF1 CDK13 RBM3

3.00e-0413334315144186
Pubmed

NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.

HNRNPDL VIRMA HNRNPAB HNRNPD

3.05e-0433334432665550
Pubmed

Immunoprecipitation and mass spectrometry defines an extensive RBM45 protein-protein interaction network.

HNRNPDL HNRNPAB HNRNPD

3.20e-0413634326979993
Pubmed

In Vitro Identification of Histatin 5 Salivary Complexes.

FLG HRNR

3.21e-042734226544073
Pubmed

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

HNRNPDL HNRNPAB HNRNPD PKP3

3.30e-0434034424332808
Pubmed

TERRA transcripts are bound by a complex array of RNA-binding proteins.

HNRNPAB HNRNPD

3.45e-042834220975687
Pubmed

rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions.

DMRTB1 MARK2 FMR1

3.63e-0414234330217970
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

HNRNPDL FLG2 CDK13 HNRNPAB RBM3 HNRNPD PKP3

3.72e-04141534728515276
Pubmed

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.

FLG KIF5C HRNR FLG2 HNRNPD

3.74e-0464134536057605
Pubmed

Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor.

FLG2 PKP3

3.97e-043034234905516
Pubmed

Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.

HNRNPDL FMR1 HNRNPAB RBM3 HNRNPD

4.05e-0465234531180492
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

HNRNPDL KIF5C FMR1 FLG2 HNRNPAB

4.28e-0466034532780723
Pubmed

S100A3 a partner protein regulating the stability/activity of RARα and PML-RARα in cellular models of breast/lung cancer and acute myeloid leukemia.

RBM3 PKP3

4.52e-043234230532072
Pubmed

The NANCI-Nkx2.1 gene duplex buffers Nkx2.1 expression to maintain lung development and homeostasis.

HNRNPAB HNRNPD

4.52e-043234228546511
Pubmed

Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress.

KIF5C HNRNPAB HNRNPD

5.06e-0415934322751105
Pubmed

Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling.

DVL2 MARK2 PKP3

5.24e-0416134336398662
Pubmed

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

HNRNPDL HRNR HNRNPAB HNRNPD

5.53e-0439034417643375
Pubmed

ATG5 is required for B cell polarization and presentation of particulate antigens.

HNRNPDL MARK2 FMR1 HNRNPAB HNRNPD

5.62e-0470134530196744
Pubmed

Thioredoxin interacting protein (Txnip) forms redox sensitive high molecular weight nucleoprotein complexes.

FLG HRNR

5.72e-043634231669268
Pubmed

Molecular composition of IMP1 ribonucleoprotein granules.

HNRNPAB HNRNPD

5.72e-043634217289661
Pubmed

An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.

HRNR FLG2 RBM3 HNRNPD

5.92e-0439734421319273
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

HNRNPDL FMR1 HNRNPAB RBM3 HNRNPD

6.07e-0471334529802200
InteractionFMR1 interactions

DVL2 KIF5C HERC2 FMR1 WTIP VIRMA HNRNPAB HNRNPD

1.84e-06536338int:FMR1
InteractionMETTL14 interactions

HNRNPDL FLG KIF5C HRNR FLG2 VIRMA HNRNPAB HNRNPD

2.48e-06558338int:METTL14
InteractionTRRAP interactions

HNRNPDL FLG SHROOM3 COL22A1 FMR1 VIRMA HNRNPAB RBM3 HNRNPD

3.45e-06790339int:TRRAP
InteractionREST interactions

DVL2 COL22A1 VIRMA HNRNPAB RBM3 HNRNPD

4.87e-06274336int:REST
InteractionDCUN1D1 interactions

DVL2 HNRNPDL FLG2 HNRNPAB RBM3 HNRNPD

4.97e-06275336int:DCUN1D1
InteractionMYCN interactions

HNRNPDL SHROOM3 MARK2 HRNR FMR1 FLG2 VIRMA CDK13 HNRNPAB RBM3 HNRNPD

6.74e-0613733311int:MYCN
InteractionCYLD interactions

HNRNPDL FLG HERC2 HRNR FMR1 FLG2 VIRMA HNRNPAB HNRNPD

7.42e-06868339int:CYLD
InteractionRAP1A interactions

HNRNPDL RAPGEF1 RASIP1 VIRMA HNRNPD

8.12e-06171335int:RAP1A
InteractionRC3H2 interactions

HNRNPDL MARK2 FMR1 VIRMA CDK13 HNRNPAB RBM3 HNRNPD

9.21e-06667338int:RC3H2
InteractionRO60 interactions

FMR1 VIRMA HNRNPAB RBM3 HNRNPD

1.73e-05200335int:RO60
InteractionHECTD1 interactions

HNRNPDL SHROOM3 MARK2 HERC2 FMR1 VIRMA CDK13 HNRNPAB HNRNPD

2.03e-05984339int:HECTD1
InteractionRARA interactions

WTIP HNRNPAB RBM3 HNRNPD PKP3

2.92e-05223335int:RARA
InteractionFLG2 interactions

FLG HRNR FLG2 VIRMA

3.27e-05112334int:FLG2
InteractionMTCL2 interactions

MARK2 HERC2 FMR1 VIRMA

3.50e-05114334int:MTCL2
InteractionC1QBP interactions

DVL2 HNRNPDL FMR1 VIRMA CDK13 HNRNPAB HNRNPD PPIF

3.60e-05806338int:C1QBP
InteractionCUL2 interactions

HNRNPDL FLG HRNR FLG2 HNRNPAB RBM3 HNRNPD

3.96e-05591337int:CUL2
InteractionDDX24 interactions

FLG HRNR FLG2 VIRMA HNRNPAB HNRNPD PKP3

4.18e-05596337int:DDX24
InteractionLARP7 interactions

HNRNPDL FLG HRNR RBMXL3 FLG2 CDK13 HNRNPAB RBM3 HNRNPD

5.35e-051113339int:LARP7
InteractionKHDRBS2 interactions

HNRNPDL HRNR RBM3 HNRNPD

5.68e-05129334int:KHDRBS2
InteractionABL1 interactions

DVL2 JAK2 RAPGEF1 VIRMA CDON

5.96e-05259335int:ABL1
InteractionFASTKD3 interactions

HNRNPDL FLG2 HNRNPAB PPIF

6.58e-05134334int:FASTKD3
InteractionDDX3X interactions

HNRNPDL FLG HERC2 HRNR FMR1 FLG2 VIRMA

7.30e-05651337int:DDX3X
InteractionMATR3 interactions

HNRNPDL HERC2 FMR1 VIRMA RBM3 HNRNPD PKP3

7.58e-05655337int:MATR3
InteractionIL7R interactions

HNRNPDL HNRNPAB RBM3 HNRNPD

8.02e-05141334int:IL7R
InteractionPKD1 interactions

JAK2 MARK2 VIRMA

8.86e-0553333int:PKD1
InteractionKIF21B interactions

DMRTB1 FMR1 VIRMA

9.90e-0555333int:KIF21B
InteractionCHD4 interactions

HNRNPDL FLG HRNR FMR1 FLG2 VIRMA HNRNPAB HNRNPD

1.05e-04938338int:CHD4
InteractionHNRNPA1 interactions

HNRNPDL FLG MARK2 HRNR FLG2 HNRNPAB RBM3 HNRNPD

1.11e-04945338int:HNRNPA1
InteractionPARD3 interactions

DVL2 SHROOM3 MARK2 FMR1 VIRMA

1.16e-04298335int:PARD3
InteractionATP9B interactions

DVL2 VIRMA

1.16e-0410332int:ATP9B
InteractionSNRPA interactions

HNRNPDL DMRTB1 VIRMA HNRNPAB RBM3 HNRNPD

1.16e-04482336int:SNRPA
InteractionYWHAE interactions

DVL2 KCNK3 JAK2 SHROOM3 MARK2 VIRMA CDK13 HNRNPAB RBM3

1.36e-041256339int:YWHAE
InteractionRNF41 interactions

DVL2 RASIP1 MARK2 FMR1

1.44e-04164334int:RNF41
InteractionIFIT2 interactions

HNRNPDL HNRNPAB HNRNPD

1.56e-0464333int:IFIT2
InteractionZNFX1 interactions

DVL2 FMR1 VIRMA

1.56e-0464333int:ZNFX1
InteractionAHNAK interactions

HNRNPDL FMR1 VIRMA HNRNPAB HNRNPD

1.57e-04318335int:AHNAK
InteractionFTH1 interactions

FLG HERC2 FLG2 VIRMA

1.81e-04174334int:FTH1
InteractionCHD3 interactions

HNRNPDL HRNR FMR1 FLG2 VIRMA HNRNPAB HNRNPD

1.87e-04757337int:CHD3
InteractionSAMD12 interactions

FLG HRNR

2.01e-0413332int:SAMD12
InteractionTP53BP1 interactions

HNRNPDL HERC2 FMR1 VIRMA HNRNPAB HNRNPD

2.01e-04533336int:TP53BP1
InteractionKIF23 interactions

HNRNPDL FLG HRNR FMR1 RBMXL3 FLG2 VIRMA HNRNPAB

2.02e-041031338int:KIF23
InteractionBTRC interactions

HNRNPDL RAPGEF1 HRNR FMR1 FLG2 HNRNPAB HNRNPD

2.16e-04775337int:BTRC
InteractionAGO1 interactions

MARK2 FMR1 VIRMA HNRNPD

2.19e-04183334int:AGO1
InteractionDSG1 interactions

FLG HRNR FLG2 PKP3

2.24e-04184334int:DSG1
InteractionKIF20A interactions

HNRNPDL SHROOM3 HERC2 FMR1 VIRMA HNRNPAB HNRNPD PKP3

2.32e-041052338int:KIF20A
InteractionKIF5B interactions

KIF5C MARK2 HERC2 FMR1 VIRMA

2.38e-04348335int:KIF5B
InteractionTBL1XR1 interactions

FMR1 VIRMA HNRNPD PPIF

2.63e-04192334int:TBL1XR1
InteractionVHL interactions

DVL2 HNRNPDL JAK2 WTIP HNRNPAB HNRNPD

2.64e-04561336int:VHL
InteractionIGF2BP2 interactions

FMR1 VIRMA HNRNPAB RBM3 HNRNPD

2.68e-04357335int:IGF2BP2
InteractionWTAP interactions

HRNR FMR1 FLG2 VIRMA

2.74e-04194334int:WTAP
InteractionIFIT3 interactions

HNRNPDL HNRNPAB HNRNPD

3.02e-0480333int:IFIT3
InteractionMTCL1 interactions

MARK2 FMR1 VIRMA

3.02e-0480333int:MTCL1
InteractionWTIP interactions

FMR1 WTIP

3.08e-0416332int:WTIP
InteractionESPL1 interactions

DVL2 VIRMA HNRNPD

3.13e-0481333int:ESPL1
InteractionUPF1 interactions

HNRNPDL HERC2 FMR1 VIRMA HNRNPAB RBM3

3.19e-04581336int:UPF1
InteractionSRA1 interactions

FMR1 HNRNPAB HNRNPD

3.36e-0483333int:SRA1
InteractionSSBP1 interactions

HNRNPDL HERC2 VIRMA HNRNPAB HNRNPD PPIF

3.40e-04588336int:SSBP1
InteractionEEF2 interactions

DVL2 HNRNPDL FMR1 VIRMA CDK13 HNRNPD

3.40e-04588336int:EEF2
InteractionILF2 interactions

HNRNPDL FMR1 VIRMA HNRNPAB RBM3 HNRNPD

3.46e-04590336int:ILF2
InteractionNEDD9 interactions

RAPGEF1 DMRTB1 VIRMA

3.61e-0485333int:NEDD9
InteractionPTDSS1 interactions

FLG HERC2 FLG2 PKP3

3.83e-04212334int:PTDSS1
InteractionTXNIP interactions

HNRNPDL FLG HERC2 HRNR

3.83e-04212334int:TXNIP
InteractionCUL4A interactions

HNRNPDL JAK2 HRNR FLG2 VIRMA HNRNPAB HNRNPD

3.89e-04854337int:CUL4A
InteractionDPRX interactions

HRNR FLG2

3.91e-0418332int:DPRX
InteractionHDLBP interactions

MARK2 HERC2 FMR1 RBMXL3 FLG2 VIRMA RBM3

3.92e-04855337int:HDLBP
InteractionKIF5C interactions

KIF5C HERC2 FMR1

3.99e-0488333int:KIF5C
InteractionNBEA interactions

FMR1 PTPRH VIRMA

4.13e-0489333int:NBEA
InteractionN4BP2 interactions

FMR1 VIRMA HNRNPAB

4.13e-0489333int:N4BP2
InteractionEML5 interactions

DVL2 HNRNPD

4.37e-0419332int:EML5
InteractionAKAP9 interactions

DVL2 HERC2 FMR1 VIRMA

4.49e-04221334int:AKAP9
InteractionCUL1 interactions

DVL2 HNRNPDL KIF5C VIRMA HNRNPAB RBM3 HNRNPD

4.54e-04876337int:CUL1
InteractionERG interactions

HNRNPDL HERC2 HNRNPAB HNRNPD

4.64e-04223334int:ERG
InteractionUBE2G2 interactions

HNRNPDL HNRNPAB HNRNPD

4.84e-0494333int:UBE2G2
InteractionDDX60L interactions

MARK2 RBM3

4.85e-0420332int:DDX60L
InteractionPPIA interactions

DVL2 HNRNPDL JAK2 FMR1 VIRMA HNRNPAB PPIF

4.92e-04888337int:PPIA
InteractionIRS2 interactions

DVL2 JAK2 VIRMA

5.00e-0495333int:IRS2
InteractionTRAPPC11 interactions

MARK2 VIRMA HNRNPD

5.15e-0496333int:TRAPPC11
InteractionILF3 interactions

HNRNPDL KIF5C FMR1 VIRMA HNRNPAB RBM3 HNRNPD

5.20e-04896337int:ILF3
InteractionCDON interactions

VIRMA CDON

5.36e-0421332int:CDON
InteractionEWSR1 interactions

HNRNPDL DMRTB1 HRNR FMR1 VIRMA HNRNPAB HNRNPD

5.55e-04906337int:EWSR1
InteractionRNF8 interactions

FLG HERC2 HRNR FLG2 HNRNPD

5.69e-04421335int:RNF8
InteractionACAD9 interactions

HNRNPDL FLG VIRMA HNRNPAB PPIF

5.69e-04421335int:ACAD9
InteractionU2AF2 interactions

DVL2 HNRNPDL HERC2 VIRMA HNRNPAB HNRNPD

5.84e-04651336int:U2AF2
InteractionNUDCD2 interactions

HNRNPDL HERC2 VIRMA HNRNPAB HNRNPD

5.88e-04424335int:NUDCD2
InteractionRASIP1 interactions

RASIP1 HNRNPD

5.88e-0422332int:RASIP1
InteractionTNIP1 interactions

FLG MARK2 FMR1 FLG2 CDK13 HNRNPAB HNRNPD PKP3

6.18e-041217338int:TNIP1
InteractionAPC2 interactions

FMR1 VIRMA

6.44e-0423332int:APC2
InteractionFZD5 interactions

DVL2 VIRMA

6.44e-0423332int:FZD5
InteractionMACF1 interactions

DVL2 HERC2 FMR1 VIRMA

6.81e-04247334int:MACF1
InteractionPCBP1 interactions

DVL2 HERC2 FMR1 VIRMA RBM3 HNRNPD

6.84e-04671336int:PCBP1
InteractionJAK1 interactions

JAK2 FLG2 VIRMA HNRNPD

6.92e-04248334int:JAK1
InteractionSNRPC interactions

HNRNPDL DMRTB1 VIRMA HNRNPAB HNRNPD

6.95e-04440335int:SNRPC
InteractionDIXDC1 interactions

FMR1 VIRMA

7.02e-0424332int:DIXDC1
InteractionINPP4A interactions

HERC2 VIRMA

7.02e-0424332int:INPP4A
InteractionBICD1 interactions

DVL2 SHROOM3 HERC2 VIRMA

7.13e-04250334int:BICD1
InteractionRC3H1 interactions

HNRNPDL MARK2 FMR1 HNRNPAB RBM3 HNRNPD

7.17e-04677336int:RC3H1
InteractionSH3RF1 interactions

DMRTB1 SHROOM3 VIRMA

7.26e-04108333int:SH3RF1
InteractionPINK1 interactions

FLG SHROOM3 MARK2 FLG2 HNRNPD PKP3

7.28e-04679336int:PINK1
InteractionYWHAG interactions

DVL2 KCNK3 JAK2 SHROOM3 KIF5C MARK2 VIRMA HNRNPAB

7.29e-041248338int:YWHAG
InteractionHSP90B2P interactions

HERC2 VIRMA

7.62e-0425332int:HSP90B2P
Cytoband1q21.3

FLG HRNR FLG2

9.11e-051173431q21.3
CytobandEnsembl 112 genes in cytogenetic band chr4q21

HNRNPDL SHROOM3 HNRNPD

1.33e-04133343chr4q21
Cytoband9q34.3

RAPGEF1 FCN2

2.82e-031063429q34.3
CytobandEnsembl 112 genes in cytogenetic band chr1q21

FLG HRNR FLG2

3.31e-03404343chr1q21
GeneFamilyEF-hand domain containing|S100 fused type protein family

FLG HRNR FLG2

9.20e-0872631350
GeneFamilyRNA binding motif containing

HNRNPDL RBMXL3 HNRNPAB RBM3 HNRNPD

1.16e-05213265725
GeneFamilyEF-hand domain containing

FLG HRNR FLG2

3.71e-03219263863
ToppCellE12.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

JAK2 RAPGEF1 RASIP1 VSTM2B WTIP

1.96e-071723453b9be685fcd1634498a603b692f5ac6ddd0de176
ToppCell(5)_Fibroblasts-(5)_Fibroblast-H|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

HNRNPDL HNRNPAB RBM3 HNRNPD PPIF

4.14e-072003450ebc54d19873a2b7b6d12b81559cb12abd73b90c
Diseaseautosomal dominant limb-girdle muscular dystrophy type 3 (implicated_via_orthology)

HNRNPDL HNRNPAB HNRNPD

2.54e-086333DOID:0110306 (implicated_via_orthology)
Diseaseneurodegenerative disease (implicated_via_orthology)

DVL2 KIF5C MARK2

5.69e-04145333DOID:1289 (implicated_via_orthology)
DiseaseUlcerative Colitis

JAK2 HERC2

2.27e-0363332C0009324
Diseasetransient cerebral ischemia (implicated_via_orthology)

JAK2 HNRNPAB

2.34e-0364332DOID:224 (implicated_via_orthology)
Diseasegut microbiome measurement, taxonomic microbiome measurement

SHROOM3 COL22A1

2.49e-0366332EFO_0007874, EFO_0007883

Protein segments in the cluster

PeptideGeneStartEntry
AHGRTGTSTGGRQGS

FLG

481

P20930
SRGGRQGSYHEQSVD

FLG

1496

P20930
RGGRQGSHYEQSVDS

FLG

1821

P20930
VRDSGHRGYSGSQAS

FLG

2031

P20930
SAHGRTGTSTGGRQG

FLG

2426

P20930
PGSSSGGRQGSHYEQ

FLG

2466

P20930
SAVRDSGHRGYSGSQ

FLG

3001

P20930
SQGYRGHISTSTGRG

CDK13

1491

Q14004
YGGGSASSQHSEGSR

DVL2

576

O14641
TREQHVFGRGGNSSG

RASIP1

401

Q5U651
AHGRGRSYSRGGGDQ

RBM3

96

P98179
SGSNRAYRHGISRGA

JAK2

126

O60674
STYGKASRGGGNHQN

HNRNPDL

401

O14979
GQSSGFGQHESRSGQ

FLG2

601

Q5D862
YGQHGSRQTSGFGQH

FLG2

631

Q5D862
GSGQSSGFGQHESRS

FLG2

751

Q5D862
GSSQSSGYGQHGSRQ

FLG2

776

Q5D862
GSGQSSGFGQHESRS

FLG2

826

Q5D862
SSGQTFGFGQHRSGS

FLG2

941

Q5D862
GQHRSSSGQYSGFGQ

FLG2

1026

Q5D862
GHGQSTQRGSRTTGR

FLG2

2011

Q5D862
GHGQSTQRGSRTAGR

FLG2

2086

Q5D862
GHGQSTQTGSRTTGR

FLG2

2161

Q5D862
GYGQSTQRGSRTTGR

FLG2

2236

Q5D862
RHGHSGYGQSTQTGS

FLG2

2306

Q5D862
GYNGTRQRGGCSNRS

SLC46A1

56

Q96NT5
GRGNYGRLGHGSSED

HERC2

576

O95714
EQSHSSPGGGGRYSD

KCNK3

341

O14649
GYGQHGSRSGQSSRG

HRNR

256

Q86YZ3
SSYGQHGSGSRQSLG

HRNR

281

Q86YZ3
SSYGQHGSGSRQSLG

HRNR

981

Q86YZ3
GHRESRSGQSSGYGQ

HRNR

1051

Q86YZ3
RSGQSSGYGQHGSSS

HRNR

1056

Q86YZ3
RGSGSRQSPSYGRHG

HRNR

1131

Q86YZ3
RQSPSYGRHGSGSGR

HRNR

1136

Q86YZ3
SGYGQHGSRSGQSSR

HRNR

1191

Q86YZ3
EGSSTGQSSSYGHRG

HRNR

1326

Q86YZ3
GQSSSYGHRGSGSSQ

HRNR

1331

Q86YZ3
SYEQHGSRSGQSSRG

HRNR

1426

Q86YZ3
SSYGQHGSGSRQSLG

HRNR

1451

Q86YZ3
GHRESRSGQSSGYGQ

HRNR

1521

Q86YZ3
RSGQSSGYGQHGSSS

HRNR

1526

Q86YZ3
RGSGSRQSPSYGRHG

HRNR

1601

Q86YZ3
RQSPSYGRHGSGSGR

HRNR

1606

Q86YZ3
SGYGQHGSRSGQSSR

HRNR

1661

Q86YZ3
SYEQHGSRSGQSSRG

HRNR

1896

Q86YZ3
GSRSGQSSRGEQHGS

HRNR

1901

Q86YZ3
SSYGQHGSGSRQSLG

HRNR

1921

Q86YZ3
GHRESRSGQSSGYGQ

HRNR

1991

Q86YZ3
RSGQSSGYGQHGSSS

HRNR

1996

Q86YZ3
RGSGSRQSPSYGRHG

HRNR

2071

Q86YZ3
RQSPSYGRHGSGSGR

HRNR

2076

Q86YZ3
SGYGQHGSRSGQSSR

HRNR

2131

Q86YZ3
SYEQHGSRSGQSSRG

HRNR

2366

Q86YZ3
SSYGQHGSGSRQSLG

HRNR

2391

Q86YZ3
GHRESRSGQSSGYGQ

HRNR

2461

Q86YZ3
RSGQSSGYGQHGSSS

HRNR

2466

Q86YZ3
RGSGSRQSPSYGRHG

HRNR

2541

Q86YZ3
RQSPSYGRHGSGSGR

HRNR

2546

Q86YZ3
SGYGQHGSRSGQSSR

HRNR

2601

Q86YZ3
EGSSTGQSSSYGHRG

HRNR

2736

Q86YZ3
GQSSSYGHRGSGSSQ

HRNR

2741

Q86YZ3
RGASTSSGQHGGRVN

FAM157C

346

P0CG43
HGRRGPGYTSGTNSE

FMR1

481

Q06787
GFRHVSRSQYQGGGL

DMRTB1

236

Q96MA1
NGRYLRGTHGSFANG

FCN2

276

Q15485
NGGLYSGHSNSLTRT

CDON

1066

Q4KMG0
RRLAYHGGNTNTGDA

COL22A1

106

Q8NFW1
SGHSQGRRGASGSIF

MARK2

621

Q7KZI7
GNNSSGIRSRHRSYG

KBTBD12

281

Q3ZCT8
HRNGDFTGGYRLGRS

NYAP1

716

Q6ZVC0
QSGYGKVSRRGGHQN

HNRNPD

336

Q14103
QGSTNYGKSQRRGGH

HNRNPAB

311

Q99729
AIRGGGGSSSNSTHY

KIF5C

941

O60282
QRPSVGGSGFGHNYR

SHROOM3

796

Q8TF72
NHNGTGGKSIYGSRF

PPIF

111

P30405
ARGTSRGQYHTLQAG

PKP3

76

Q9Y446
RGDGNQNGYRGRDHE

RBMXL3

276

Q8N7X1
HDSSSQSNRYGGGGC

RBMXL3

576

Q8N7X1
NSGGRSPDAYSGGHD

RBMXL3

641

Q8N7X1
SQSDHYGGGGRSLDA

RBMXL3

736

Q8N7X1
GGHSPNAYSGGRDSS

RBMXL3

831

Q8N7X1
GGRGLNSSNNSHGRS

RBMXL3

926

Q8N7X1
NSSNNSHGRSHRYGG

RBMXL3

931

Q8N7X1
QRRLSGGSHSYGGES

RAPGEF1

331

Q13905
RQRHGSGTGRSYTTD

VSTM2B

251

A6NLU5
GRSHSSAGVRQGFSG

ZNF843

86

Q8N446
RSSGISLGYDQRHGS

WTIP

106

A6NIX2
YTGDGGRAGTRSTAH

PTPRH

156

Q9HD43
SGNRGGRGAFHSQNR

VIRMA

1691

Q69YN4