Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	iron-responsive element binding	IREB2 ACO1	1.69e-05	3	48	2	GO:0030350
GeneOntologyMolecularFunction	aconitate hydratase activity	IREB2 ACO1	1.69e-05	3	48	2	GO:0003994
GeneOntologyBiologicalProcess	monoatomic cation homeostasis	SLC9A7 IREB2 IBTK PLCB3 EFHC1 SLC12A9 ACO1 SLC39A7 RYR1	2.57e-05	705	47	9	GO:0055080
GeneOntologyBiologicalProcess	monoatomic ion homeostasis	SLC9A7 IREB2 IBTK PLCB3 EFHC1 SLC12A9 ACO1 SLC39A7 RYR1	2.94e-05	717	47	9	GO:0050801
GeneOntologyBiologicalProcess	citrate metabolic process	IREB2 ACO1	5.06e-05	5	47	2	GO:0006101
GeneOntologyBiologicalProcess	cellular homeostasis	SLC9A7 IREB2 IBTK PLCB3 EFHC1 CLCN6 SLC12A9 ACO1 SLC39A7 RYR1	5.88e-05	981	47	10	GO:0019725
GeneOntologyBiologicalProcess	intracellular monoatomic cation homeostasis	SLC9A7 IREB2 IBTK PLCB3 EFHC1 ACO1 SLC39A7 RYR1	6.42e-05	611	47	8	GO:0030003
GeneOntologyBiologicalProcess	intracellular monoatomic ion homeostasis	SLC9A7 IREB2 IBTK PLCB3 EFHC1 ACO1 SLC39A7 RYR1	7.28e-05	622	47	8	GO:0006873
GeneOntologyBiologicalProcess	inorganic ion homeostasis	IREB2 IBTK PLCB3 EFHC1 SLC12A9 ACO1 SLC39A7 RYR1	7.28e-05	622	47	8	GO:0098771
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	SLC9A7 KCNS1 IBTK PLCB3 TCAF1 NEDD4L CLCN6 SLC12A9 SLC39A7 RYR1	1.70e-04	1115	47	10	GO:0034220
Domain	Aconitase/IRP2	IREB2 ACO1	6.20e-06	2	47	2	IPR006249
Domain	-	IREB2 ACO1	1.86e-05	3	47	2	3.40.1060.10
Domain	-	IREB2 ACO1	1.86e-05	3	47	2	3.20.19.10
Domain	Acoase/IPM_deHydtase	IREB2 ACO1	1.86e-05	3	47	2	IPR015937
Domain	Acnase/IPM_dHydase_lsu_aba_1/3	IREB2 ACO1	1.86e-05	3	47	2	IPR015931
Domain	Aconitase/IPMdHydase_lsu_aba_2	IREB2 ACO1	1.86e-05	3	47	2	IPR015932
Domain	AconitaseA/IPMdHydase_ssu_swvl	IREB2 ACO1	1.86e-05	3	47	2	IPR000573
Domain	ACONITASE_1	IREB2 ACO1	1.86e-05	3	47	2	PS00450
Domain	Aconitase/3IPM_dehydase_swvl	IREB2 ACO1	1.86e-05	3	47	2	IPR015928
Domain	Aconitase_C	IREB2 ACO1	1.86e-05	3	47	2	PF00694
Domain	Aconitase	IREB2 ACO1	1.86e-05	3	47	2	PF00330
Domain	Aconitase_4Fe-4S_BS	IREB2 ACO1	1.86e-05	3	47	2	IPR018136
Domain	-	IREB2 ACO1	1.86e-05	3	47	2	3.30.499.10
Domain	ACONITASE_2	IREB2 ACO1	1.86e-05	3	47	2	PS01244
Domain	Acoase/IPM_deHydtase_lsu_aba	IREB2 ACO1	1.86e-05	3	47	2	IPR001030
Domain	-	CD9 TSPAN2	6.17e-05	5	47	2	1.10.1450.10
Domain	CD81_LEL	CD9 TSPAN2	6.17e-05	5	47	2	IPR028977
Domain	Tetraspanin_CS	CD9 TSPAN2	1.26e-03	21	47	2	IPR018503
Domain	PROTEIN_KINASE_TYR	OBSCN MST1R FLT4	1.87e-03	97	47	3	PS00109
Domain	Tyr_kinase_AS	OBSCN MST1R FLT4	1.87e-03	97	47	3	IPR008266
Domain	TM4_1	CD9 TSPAN2	1.94e-03	26	47	2	PS00421
Domain	Protein_kinase_ATP_BS	CDK20 OBSCN MST1R FLT4 ULK2	2.55e-03	379	47	5	IPR017441
Domain	Tetraspanin	CD9 TSPAN2	2.93e-03	32	47	2	IPR000301
Domain	Tetraspanin_EC2	CD9 TSPAN2	2.93e-03	32	47	2	IPR008952
Domain	Tetraspannin	CD9 TSPAN2	3.11e-03	33	47	2	PF00335
Domain	Tetraspanin/Peripherin	CD9 TSPAN2	3.11e-03	33	47	2	IPR018499
Domain	C2	PLCB3 NEDD4L DOC2B	4.37e-03	131	47	3	PF00168
Domain	C2	PLCB3 NEDD4L DOC2B	4.95e-03	137	47	3	SM00239
Domain	Rossmann-like_a/b/a_fold	RARS1 NMNAT3	5.24e-03	43	47	2	IPR014729
Domain	-	RARS1 NMNAT3	5.24e-03	43	47	2	3.40.50.620
Domain	C2	PLCB3 NEDD4L DOC2B	5.46e-03	142	47	3	PS50004
Domain	PROTEIN_KINASE_ATP	CDK20 OBSCN MST1R FLT4 ULK2	5.76e-03	459	47	5	PS00107
Domain	-	PLCB3 NEDD4L DOC2B	6.13e-03	148	47	3	2.60.40.150
Domain	WW	MAGI2 NEDD4L	6.23e-03	47	47	2	PF00397
Domain	WW	MAGI2 NEDD4L	6.49e-03	48	47	2	SM00456
Domain	WW_DOMAIN_2	MAGI2 NEDD4L	7.31e-03	51	47	2	PS50020
Domain	WW_DOMAIN_1	MAGI2 NEDD4L	7.31e-03	51	47	2	PS01159
Domain	Prot_kinase_dom	CDK20 OBSCN MST1R FLT4 ULK2	7.48e-03	489	47	5	IPR000719
Pubmed	Subcellular localization of iron regulatory proteins to Golgi and ER membranes.	IREB2 ACO1	1.87e-06	2	48	2	16144863
Pubmed	Iron regulatory proteins secure mitochondrial iron sufficiency and function.	IREB2 ACO1	1.87e-06	2	48	2	20674864
Pubmed	Excess capacity of the iron regulatory protein system.	IREB2 ACO1	1.87e-06	2	48	2	17604281
Pubmed	Electron tomography of degenerating neurons in mice with abnormal regulation of iron metabolism.	IREB2 ACO1	1.87e-06	2	48	2	15866737
Pubmed	A regulated RNA binding protein also possesses aconitase activity.	IREB2 ACO1	1.87e-06	2	48	2	1946430
Pubmed	Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes.	IREB2 ACO1	1.87e-06	2	48	2	16283625
Pubmed	Iron regulatory proteins 1 and 2 have opposing roles in regulating inflammation in bacterial orchitis.	IREB2 ACO1	1.87e-06	2	48	2	38301068
Pubmed	Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis.	IREB2 ACO1	1.87e-06	2	48	2	14726953
Pubmed	Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein.	IREB2 ACO1	1.87e-06	2	48	2	2172968
Pubmed	Effect of hypoxia on the binding and subcellular distribution of iron regulatory proteins.	IREB2 ACO1	1.87e-06	2	48	2	17200797
Pubmed	Genetic polymorphism of the iron-regulatory protein-1 and -2 genes in age-related macular degeneration.	IREB2 ACO1	1.87e-06	2	48	2	22331484
Pubmed	Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation.	IREB2 ACO1	1.87e-06	2	48	2	7983023
Pubmed	In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation.	IREB2 ACO1	1.87e-06	2	48	2	19533074
Pubmed	Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2.	IREB2 ACO1	1.87e-06	2	48	2	15831703
Pubmed	Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins.	IREB2 ACO1	1.87e-06	2	48	2	25771171
Pubmed	Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo.	IREB2 ACO1	1.87e-06	2	48	2	15208438
Pubmed	Iron regulatory proteins increase neuronal vulnerability to hydrogen peroxide.	IREB2 ACO1	1.87e-06	2	48	2	18655771
Pubmed	Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements.	IREB2 ACO1	1.87e-06	2	48	2	8262972
Pubmed	Effects of iron regulatory protein regulation on iron homeostasis during hypoxia.	IREB2 ACO1	1.87e-06	2	48	2	12855587
Pubmed	Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency.	IREB2 ACO1	1.87e-06	2	48	2	16503547
Pubmed	Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide.	IREB2 ACO1	1.87e-06	2	48	2	21566147
Pubmed	Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo.	IREB2 ACO1	1.87e-06	2	48	2	15604406
Pubmed	Self-association and ligand-induced conformational changes of iron regulatory proteins 1 and 2.	IREB2 ACO1	1.87e-06	2	48	2	15938636
Pubmed	The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation.	IREB2 ACO1	1.87e-06	2	48	2	8041788
Pubmed	Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms.	IREB2 ACO1	1.87e-06	2	48	2	38773499
Pubmed	Iron regulatory protein (IRP)-mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow.	IREB2 ACO1	5.59e-06	3	48	2	36197975
Pubmed	Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum.	IREB2 ACO1	5.59e-06	3	48	2	18177727
Pubmed	Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery.	IREB2 ACO1	5.59e-06	3	48	2	19965627
Pubmed	Knockdown of FLT4, Nup98, and Nup205 Cellular Genes Effectively Suppresses the Reproduction of Influenza Virus Strain A/WSN/1933 (H1N1) In vitro.	FLT4 NUP205	5.59e-06	3	48	2	35339191
Pubmed	IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation.	IREB2 ACO1	5.59e-06	3	48	2	23777768
Pubmed	Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins.	IREB2 ACO1	5.59e-06	3	48	2	21940823
Pubmed	The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption.	IREB2 ACO1	5.59e-06	3	48	2	23395174
Pubmed	Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice.	IREB2 ACO1	5.59e-06	3	48	2	22003390
Pubmed	F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis.	IREB2 ACO1	5.59e-06	3	48	2	23135277
Pubmed	Iron homeostasis during transfusional iron overload in beta-thalassemia and sickle cell disease: changes in iron regulatory protein, hepcidin, and ferritin expression.	IREB2 ACO1	5.59e-06	3	48	2	17613866
Pubmed	Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection.	IREB2 ACO1	5.59e-06	3	48	2	26190773
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	CDK20 PAN2 WDR83 SPAG9 ASAP2 EFHC1 HSF1 PPID MRPS25 NUP205	1.06e-05	1321	48	10	27173435
Pubmed	Iron regulatory protein 1 sustains mitochondrial iron loading and function in frataxin deficiency.	IREB2 ACO1	1.12e-05	4	48	2	25651183
Pubmed	Essential role of systemic iron mobilization and redistribution for adaptive thermogenesis through HIF2-α/hepcidin axis.	IREB2 ACO1	1.12e-05	4	48	2	34593646
Pubmed	Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina.	IREB2 ACO1	1.12e-05	4	48	2	15354085
Pubmed	Control of iron homeostasis by an iron-regulated ubiquitin ligase.	IREB2 ACO1	1.86e-05	5	48	2	19762596
Pubmed	HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.	IREB2 ACO1	2.79e-05	6	48	2	24778179
Pubmed	An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis.	IREB2 ACO1	2.79e-05	6	48	2	19762597
Pubmed	An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.	IREB2 ACO1	3.90e-05	7	48	2	31229404
Pubmed	A study of genes that may modulate the expression of hereditary hemochromatosis: transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (IRP)-1 and -2, and hepcidin.	IREB2 ACO1	5.19e-05	8	48	2	11783942
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	MAGI2 IBTK SPAG9 ASAP2 RARS1 FSCN1 MRPS25 SLC39A7 NUP205	5.67e-05	1284	48	9	17353931
Pubmed	A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor.	HSF1 PPID	8.33e-05	10	48	2	9222609
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	WDR83 IREB2 IBTK SEM1 NUP205	9.27e-05	331	48	5	19490893
Pubmed	Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.	ZAN SLC12A9	1.44e-04	13	48	2	11239002
Pubmed	Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins.	MAGI2 NEDD4L	1.94e-04	15	48	2	23236378
Pubmed	The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.	IREB2 ACO1	2.21e-04	16	48	2	21907140
Pubmed	Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping.	NEDD4L ZNF236	2.50e-04	17	48	2	19690890
Pubmed	Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development.	IREB2 ACO1	3.14e-04	19	48	2	16787915
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	PAN2 MAGI2 ULK2	3.85e-04	102	48	3	9734811
Pubmed	Lymphatic function is required prenatally for lung inflation at birth.	FLT4 ABCA3	5.05e-04	24	48	2	24733830
Pubmed	Complexes of tetraspanins with integrins: more than meets the eye.	CD9 TSPAN2	5.05e-04	24	48	2	11739647
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	OBSCN SPAG9 PLCB3 RARS1 RYR1 NUP205	5.07e-04	736	48	6	29676528
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	WDR83 IREB2 IBTK TCAF1 RARS1 NEDD4L SLC39A7 NUP205	5.29e-04	1371	48	8	36244648
Pubmed	Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.	MAGI2 NEDD4L	5.48e-04	25	48	2	23873930
Pubmed	FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells.	IREB2 ACO1	5.48e-04	25	48	2	28069738
Pubmed	Analysis of a lung defect in autophagy-deficient mouse strains.	ABCA3 ULK2	5.93e-04	26	48	2	24275123
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	EMG1 PLCB3 TCAF1 RARS1 NEDD4L FSCN1 HSF1 MRPS25	6.51e-04	1415	48	8	28515276
Pubmed	Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.	MST1R FLT4	6.89e-04	28	48	2	18593464
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	IREB2 SPAG9 PLCB3 RARS1 HSF1 PPID ACO1 NUP205	7.81e-04	1455	48	8	22863883
Pubmed	Maternal synchronization of gestational length and lung maturation.	FLT4 ABCA3	8.45e-04	31	48	2	22096492
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	IBTK TCAF1 PPID MRPS25 NUP205	9.26e-04	547	48	5	37267103
Pubmed	Ion channel expression in the developing enteric nervous system.	KCNS1 CLCN6	1.20e-03	37	48	2	25798587
Cytoband	12p13.3	EMG1 CD9	4.57e-04	30	48	2	12p13.3
Cytoband	7q22	ZAN SLC12A9	7.35e-04	38	48	2	7q22
Coexpression	MILI_PSEUDOPODIA_CHEMOTAXIS_DN	ABCA3 NEDD4L CD9 CLCN6 HSF1 SLC12A9 SLC39A7	1.61e-05	457	47	7	M1613
Coexpression	MILI_PSEUDOPODIA_CHEMOTAXIS_DN	ABCA3 NEDD4L CD9 CLCN6 HSF1 SLC12A9 SLC39A7	1.93e-05	470	47	7	MM1053
Coexpression	GSE16385_UNTREATED_VS_12H_IFNG_TNF_TREATED_MACROPHAGE_DN	EMG1 RARS1 FSCN1 SLC12A9 RNF144A	2.64e-05	196	47	5	M7936
Coexpression	GSE22886_IGM_MEMORY_BCELL_VS_BM_PLASMA_CELL_DN	OBSCN ABHD8 CD9 HSF1 SLC39A7	2.84e-05	199	47	5	M4457
Coexpression	GSE41867_DAY6_EFFECTOR_VS_DAY30_EXHAUSTED_CD8_TCELL_LCMV_CLONE13_DN	IBTK SPAG9 DESI1 ULK2 RYR1	2.91e-05	200	47	5	M9490
Coexpression	HE_LIM_SUN_FETAL_LUNG_C0_ACTC_POS_SMC_CELL	CDK20 PTCH2 PLCB3 ASAP2 ABHD8 NEDD4L TSPAN2	8.05e-05	589	47	7	M45662
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Vein\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SPAG9 FSCN1 CD9 TSPAN2 DOC2B	2.42e-06	200	48	5	b3f93b71589251197cde96b7bc6d065c106f61cd
ToppCell	Control-Hematopoietic_Meg-Ery-Platelets-Platelets\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DESI1 CD9 TSPAN2 DOC2B	2.53e-05	158	48	4	f2c39b2eff8f2728a9d482d88e0d04984306a3fd
ToppCell	Control-Hematopoietic_Meg-Ery-Platelets\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DESI1 CD9 TSPAN2 DOC2B	2.53e-05	158	48	4	fa9797a23254070c569fabe8a314b3e8b3ae9ebd
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPAG9 ASAP2 CD9 RNF144A	5.18e-05	190	48	4	9b0ad888eb20acc011904d8593bc32bdef18d050
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPAG9 ASAP2 CD9 RNF144A	5.40e-05	192	48	4	c157981b9a179925edcaabc0cb3b8805f0929004
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DESI1 FSCN1 CD9 TSPAN2	5.40e-05	192	48	4	3916de42b9a626b5679ca98057d6e69f146b2810
ToppCell	E18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ABCA3 NEDD4L CD9 TSPAN2	5.51e-05	193	48	4	54506c0da2f219f472b95e8935a78b657a8dec41
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ASAP2 FSCN1 TSPAN2 RNF144A	5.51e-05	193	48	4	e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCell	E18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ABCA3 NEDD4L CD9 TSPAN2	5.51e-05	193	48	4	2d42721fac1bee294ede47d609bebb3e7d36bf0c
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DESI1 FSCN1 CD9 TSPAN2	5.62e-05	194	48	4	61b59f8e2c68851d827b058cf03904f8125e8047
ToppCell	PND01-Epithelial\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ABCA3 NEDD4L CD9 TSPAN2	5.62e-05	194	48	4	d21db5e942966ed44bc78ff50130a201fc627074
ToppCell	PND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ABCA3 NEDD4L CD9 TSPAN2	5.73e-05	195	48	4	43164511f32e4591cb5399182fbac0b911716233
ToppCell	PND01-Epithelial-Epithelial_Alveolar\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ABCA3 NEDD4L CD9 TSPAN2	5.73e-05	195	48	4	9337111d75a487abc02969337718c30b1fe81379
ToppCell	proximal-3-Hematologic-IGSF21+_Dendritic\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CDK20 PTCH2 SLC9A7 ULK2	5.73e-05	195	48	4	8592d0332bc82a91e173680cfd1afc5ee189b289
ToppCell	proximal-Hematologic-IGSF21+_Dendritic\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CDK20 PTCH2 SLC9A7 ULK2	5.73e-05	195	48	4	c48ff83c48342875f06c6c9e7d5bc6084a992848
ToppCell	facs-Heart-RA-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ASAP2 FSCN1 TSPAN2	5.73e-05	195	48	4	30c75761079fa1e1a3b84d23c88a222f459d5ce5
ToppCell	proximal-Hematologic-IGSF21+_Dendritic-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CDK20 PTCH2 SLC9A7 ULK2	5.73e-05	195	48	4	ae9d61011e95f7840cbb154738c79745fd29943e
ToppCell	Healthy_donor-cDC\|World / disease group, cell group and cell class (v2)	SLC9A7 FSCN1 SLC12A9 RYR1	5.97e-05	197	48	4	a545fe3a80cd721bf01115bbb645753840ec9f40
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Vein\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FSCN1 CD9 TSPAN2 DOC2B	6.20e-05	199	48	4	cfb624c7728046fc7f3ef071f57e4d7b013f3fef
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ASAP2 FSCN1 TSPAN2 DOC2B	6.33e-05	200	48	4	a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ASAP2 CD9 TSPAN2 DOC2B	6.33e-05	200	48	4	2d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	ASAP2 FSCN1 TSPAN2 RNF144A	6.33e-05	200	48	4	eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCell	Influenza-Influenza_Severe-Myeloid-cDC\|Influenza_Severe / Disease, condition lineage and cell class	SLC9A7 EFHC1 FSCN1 MRPS25	6.33e-05	200	48	4	b8415a68ad6f4fea562236a1b0da0dc376d874fb
Drug	Trapidil [15421-84-8]; Down 200; 19.4uM; MCF7; HT_HG-U133A	KCNS1 PLCB3 FLT4 FSCN1 ZNF236 ULK2	3.63e-06	198	48	6	6515_DN
Drug	p-nitrophenylhydroxylamine	IREB2 ACO1	4.35e-06	2	48	2	CID005486551
Drug	BFNU	IREB2 ACO1	2.60e-05	4	48	2	CID000096886
Drug	2-hydroxyisonicotinate	IREB2 ACO1	2.60e-05	4	48	2	CID000280756
Drug	Cicloral	IREB2 ACO1	2.60e-05	4	48	2	CID000012628
Drug	cADPR	PLCB3 CD9 RYR1 NMNAT3	2.70e-05	82	48	4	CID000123847
Drug	croconic acid	IREB2 ACO1	4.33e-05	5	48	2	CID000546874
Drug	AC1NSY0C	IREB2 ACO1	4.33e-05	5	48	2	CID005372273
Drug	p-nitroacetanilide	IREB2 ACO1	4.33e-05	5	48	2	CID000007691
Drug	1,3-difluoroacetone	IREB2 ACO1	4.33e-05	5	48	2	CID000228397
Drug	1,3-difluoro-2-propanol	IREB2 ACO1	4.33e-05	5	48	2	CID000067985
Drug	fluoroacetaldehyde	IREB2 ACO1	4.33e-05	5	48	2	CID000073766
Drug	gliftor	IREB2 ACO1	4.33e-05	5	48	2	CID000197109
Drug	cinchoninic acid	IREB2 ACO1	4.33e-05	5	48	2	CID000010243
Drug	Podophyllotoxin [518-28-5]; Up 200; 9.6uM; MCF7; HT_HG-U133A	ABHD8 NEDD4L CLCN6 TSPAN2 RYR1	5.29e-05	193	48	5	6103_UP
Drug	Griseofulvin [126-07-8]; Down 200; 11.2uM; HL60; HT_HG-U133A	PAN2 IREB2 EFHC1 FSCN1 CLCN6	5.29e-05	193	48	5	2332_DN
Drug	Bromopride [4093-35-0]; Down 200; 11.6uM; HL60; HT_HG-U133A	KCNS1 PLCB3 FSCN1 CD9 ULK2	5.98e-05	198	48	5	2182_DN
Drug	Ketoprofen [22071-15-4]; Down 200; 15.8uM; MCF7; HT_HG-U133A	KCNS1 FLT4 FSCN1 CLCN6 SLC12A9	5.98e-05	198	48	5	2316_DN
Drug	Neomycin sulfate [1405-10-3]; Up 200; 4.2uM; HL60; HG-U133A	CDK20 PAN2 RARS1 CLCN6 RNF144A	6.12e-05	199	48	5	1383_UP
Drug	PHA-00846566E [724718-26-7]; Down 200; 10uM; MCF7; HT_HG-U133A	IREB2 SPAG9 PLCB3 FSCN1 SLC12A9	6.27e-05	200	48	5	7081_DN
Drug	manganese pyrophosphate	IREB2 ACO1	6.49e-05	6	48	2	CID000152037
Drug	oxalomalic acid	IREB2 ACO1	6.49e-05	6	48	2	CID000439620
Drug	FE-S CLUSTER	IREB2 ACO1	6.49e-05	6	48	2	CID006416167
Drug	AC1L3C9O	IREB2 CD9 PPID ACO1	8.52e-05	110	48	4	CID000002521
Drug	Fc nu	IREB2 ACO1	9.08e-05	7	48	2	CID000083807
Drug	C04226	IREB2 ACO1	1.21e-04	8	48	2	CID000151255
Drug	citrazinic acid	IREB2 ACO1	1.21e-04	8	48	2	CID000007425
Drug	3-methylitaconate	IREB2 ACO1	1.21e-04	8	48	2	CID006438940
Drug	Mn(III)TMPyP	IREB2 ACO1	1.55e-04	9	48	2	CID005486195
Drug	NSC-254681	IREB2 ACO1	1.55e-04	9	48	2	CID005458489
Drug	Ferrosanol	IREB2 ACO1	1.55e-04	9	48	2	CID000028366
Drug	2-hydroxypalmitic acid	IREB2 ACO1	1.55e-04	9	48	2	CID000092836
Disease	porphyria (implicated_via_orthology)	IREB2 ACO1	2.27e-05	5	45	2	DOID:13268 (implicated_via_orthology)
Disease	Epileptic encephalopathy	MAGI2 NEDD4L	9.63e-04	30	45	2	C0543888
Disease	endometrial cancer (is_marker_for)	SPAG9 CD9	1.31e-03	35	45	2	DOID:1380 (is_marker_for)
Disease	left ventricular systolic function measurement	OBSCN NEDD4L	2.07e-03	44	45	2	EFO_0008206
Disease	folic acid measurement	MAGI2 FLT4	2.26e-03	46	45	2	EFO_0005111

Protein segments in the cluster

Peptide	Gene	Start	Entry
KHLRQVGVVGKFVEF	ACO1	266	P21399
ILGRIGEGAHGIVFK	CDK20	6	Q8IZL9
FVGGHRISSDVGKVR	ABCA3	1441	Q99758
TFRGKIHAFRGQILG	CCDC70	71	Q6NSX1
VVLFFIHGVGGSLAI	ABHD8	176	Q96I13
KHLRQVGVAGKFVEF	IREB2	341	P48200
FILKTGGGFQRVRTH	NUP205	1406	Q92621
GHRDAVKFFVAVPGQ	SPAG9	1221	O60271
HAVIGRIGFVGLFRS	OR52D1	141	Q9H346
FLIDIGVKFVGHGLQ	PAN2	1071	Q504Q3
GVKFVGHGLQKDFRV	PAN2	1076	Q504Q3
GCIAQIFFIHVIGGV	OR4F21	96	O95013
VVIHRKENEGFGFVI	MAGI2	921	Q86UL8
LKGRTIIGVAAGRFH	IBTK	281	Q9P2D0
GRKGAFPVSFVHFIA	ASAP2	991	O43150
YGFRKVVHIEQGGLV	HSF1	76	Q00613
GKEFGHLGKVVQVFR	KCNS1	331	Q96KK3
HRTQVVGIFAGFGLL	RNF144A	246	P50876
EKAGIIRYAIGVGHA	ITGAD	276	Q13349
RGVFGFVKRVQHKGN	OBSCN	6476	Q5VST9
IAAFEEGGKFVGHRI	PLCB3	796	Q01970
NKFHIIGAVGIGIAV	CD9	191	P21926
FNKGIYDIHVGLRGV	CLCN6	571	P51797
FIGGVVLGIHAKGER	DOC2B	366	Q14184
IVFRGEHGFIGCRKV	FSCN1	386	Q16658
IVVHKDEFFFGSGGI	DESI1	41	Q6ICB0
FIGAVIEVFGHRFII	EFHC1	491	Q5JVL4
VKVRFLLGGRHGEFK	RYR1	786	P21817
GKTIFNFGDVAVGHR	CFAP74	1246	Q9C0B2
GCIAQIFFIHVVGGV	OR4F3;	96	Q6IEY1
THGELGEGARKFVFF	MRPS25	36	P82663
FAVFDVIKRKGGGHV	RTP5	476	Q14D33
PKVTRVFHAGFGVVL	RARS1	431	P54136
GRVVVTGHKVLFTVG	TCAF1	266	Q9Y4C2
HVVFGQVIKGIGVAR	PPID	146	Q08752
VGIGVEFTVHVALGF	PTCH2	1026	Q9Y6C5
VFAVQGGKVGRKHGI	SEM1	11	Q6ZVN7
LVVEKFVRHVKGGHG	SLC39A7	231	Q92504
VFLRIGFVVGHAGLL	SLC12A9	56	Q9BXP2
HLGRVLGYGAFGKVV	FLT4	846	P35916
VASGQVVRKFRGHAG	WDR83	96	Q9BRX9
IVFVVGAFAHGKVSV	EMG1	196	Q92979
KRDLVGHGAFAVVFR	ULK2	11	Q8IYT8
GRGFVSAGVLKAHIR	ZNF236	691	Q9UL36
GVFAFIGKGVAIRHV	TSPAN2	106	O60636
IGAFVAIFLGRAAHI	SLC9A7	446	Q96T83
RVIGKGHFGVVYHGE	MST1R	1086	Q04912
AVGRIQFAVVGVFGK	ZAN	336	Q9Y493
IVEKFGLVCVGRVGH	NMNAT3	156	Q96T66
TFIGRVAGLAVFHGK	NEDD4L	711	Q96PU5