Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionretinoic acid binding

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.61e-1128165GO:0001972
GeneOntologyMolecularFunctionglucuronosyltransferase activity

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

5.29e-1135165GO:0015020
GeneOntologyMolecularFunctionretinoid binding

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.77e-1048165GO:0005501
GeneOntologyMolecularFunctionisoprenoid binding

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

3.09e-1049165GO:0019840
GeneOntologyMolecularFunctionmonocarboxylic acid binding

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.68e-08107165GO:0033293
GeneOntologyMolecularFunctionUDP-glycosyltransferase activity

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.01e-07153165GO:0008194
GeneOntologyMolecularFunctionprotein heterodimerization activity

UGT1A4 UGT1A1 UGT1A3 MIGA1 UGT1A6 UGT1A5

4.08e-07398166GO:0046982
GeneOntologyMolecularFunctionhexosyltransferase activity

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

4.99e-07211165GO:0016758
GeneOntologyMolecularFunctioncarboxylic acid binding

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

9.24e-07239165GO:0031406
GeneOntologyMolecularFunctionorganic acid binding

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.25e-06254165GO:0043177
GeneOntologyMolecularFunctionglycosyltransferase activity

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.31e-06288165GO:0016757
GeneOntologyMolecularFunctionprotein homodimerization activity

UGT1A4 UGT1A1 UGT1A3 MIGA1 UGT1A6 UGT1A5

2.56e-05815166GO:0042803
GeneOntologyMolecularFunctionlipid binding

UGT1A4 UGT1A1 UGT1A3 UGT1A6 NR3C2 UGT1A5

7.54e-05988166GO:0008289
GeneOntologyMolecularFunctionprotein dimerization activity

UGT1A4 UGT1A1 UGT1A3 MIGA1 UGT1A6 UGT1A5

2.26e-041205166GO:0046983
GeneOntologyMolecularFunctionsteroid binding

UGT1A1 NR3C2

4.97e-03133162GO:0005496
GeneOntologyMolecularFunctiontranscription coregulator binding

NR3C2 PER3

5.49e-03140162GO:0001221
GeneOntologyBiologicalProcesscellular glucuronidation

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.84e-1221165GO:0052695
GeneOntologyBiologicalProcessglucuronate metabolic process

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

9.15e-1226165GO:0019585
GeneOntologyBiologicalProcessuronic acid metabolic process

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

9.15e-1226165GO:0006063
GeneOntologyBiologicalProcessbilirubin conjugation

UGT1A4 UGT1A1

5.64e-072162GO:0006789
GeneOntologyBiologicalProcessflavonoid glucuronidation

UGT1A1 UGT1A3

5.63e-065162GO:0052696
GeneOntologyBiologicalProcessvitamin D3 metabolic process

UGT1A4 UGT1A3

2.02e-059162GO:0070640
GeneOntologyBiologicalProcesscellular response to corticosteroid stimulus

UGT1A1 UGT1A6 NR3C2

3.15e-0581163GO:0071384
GeneOntologyBiologicalProcessxenobiotic glucuronidation

UGT1A1 UGT1A3

3.71e-0512162GO:0052697
GeneOntologyBiologicalProcessporphyrin-containing compound catabolic process

UGT1A4 UGT1A1

4.38e-0513162GO:0006787
GeneOntologyBiologicalProcessflavonoid metabolic process

UGT1A1 UGT1A3

4.38e-0513162GO:0009812
GeneOntologyBiologicalProcesstetrapyrrole catabolic process

UGT1A4 UGT1A1

5.11e-0514162GO:0033015
GeneOntologyBiologicalProcessvitamin D metabolic process

UGT1A4 UGT1A3

1.41e-0423162GO:0042359
GeneOntologyBiologicalProcessxenobiotic metabolic process

UGT1A1 UGT1A3 UGT1A6

1.64e-04141163GO:0006805
GeneOntologyBiologicalProcessmonocarboxylic acid metabolic process

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.74e-04731165GO:0032787
GeneOntologyBiologicalProcessresponse to corticosteroid

UGT1A1 UGT1A6 NR3C2

3.65e-04185163GO:0031960
GeneOntologyBiologicalProcessbenzene-containing compound metabolic process

UGT1A1 UGT1A6

3.70e-0437162GO:0042537
GeneOntologyBiologicalProcessretinoic acid metabolic process

UGT1A1 UGT1A3

4.33e-0440162GO:0042573
GeneOntologyBiologicalProcessresponse to xenobiotic stimulus

UGT1A1 UGT1A3 PRICKLE1 UGT1A6

5.92e-04525164GO:0009410
GeneOntologyBiologicalProcesscellular response to xenobiotic stimulus

UGT1A1 UGT1A3 UGT1A6

6.21e-04222163GO:0071466
GeneOntologyBiologicalProcessfat-soluble vitamin metabolic process

UGT1A4 UGT1A3

7.04e-0451162GO:0006775
GeneOntologyBiologicalProcessestrogen metabolic process

UGT1A1 UGT1A3

7.31e-0452162GO:0008210
GeneOntologyBiologicalProcesscellular response to steroid hormone stimulus

UGT1A1 UGT1A6 NR3C2

7.70e-04239163GO:0071383
GeneOntologyBiologicalProcesscarboxylic acid metabolic process

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

8.65e-041035165GO:0019752
GeneOntologyBiologicalProcessoxoacid metabolic process

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

9.56e-041058165GO:0043436
GeneOntologyBiologicalProcessorganic acid metabolic process

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

9.80e-041064165GO:0006082
GeneOntologyBiologicalProcessporphyrin-containing compound metabolic process

UGT1A4 UGT1A1

1.07e-0363162GO:0006778
GeneOntologyBiologicalProcesscellular response to glucocorticoid stimulus

UGT1A1 UGT1A6

1.25e-0368162GO:0071385
GeneOntologyBiologicalProcesstetrapyrrole metabolic process

UGT1A4 UGT1A1

1.44e-0373162GO:0033013
GeneOntologyBiologicalProcessretinoid metabolic process

UGT1A1 UGT1A3

2.12e-0389162GO:0001523
GeneOntologyBiologicalProcesspigment metabolic process

UGT1A4 UGT1A1

2.37e-0394162GO:0042440
GeneOntologyBiologicalProcessditerpenoid metabolic process

UGT1A1 UGT1A3

2.37e-0394162GO:0016101
GeneOntologyBiologicalProcesssteroid metabolic process

UGT1A4 UGT1A1 UGT1A3

2.82e-03376163GO:0008202
GeneOntologyBiologicalProcessresponse to steroid hormone

UGT1A1 UGT1A6 NR3C2

2.93e-03381163GO:0048545
GeneOntologyBiologicalProcessterpenoid metabolic process

UGT1A1 UGT1A3

2.94e-03105162GO:0006721
GeneOntologyBiologicalProcessrenal tubule development

PRICKLE1 GZF1

3.57e-03116162GO:0061326
GeneOntologyBiologicalProcesscellular response to alcohol

UGT1A1 NR3C2

4.46e-03130162GO:0097306
GeneOntologyBiologicalProcessvitamin metabolic process

UGT1A4 UGT1A3

4.67e-03133162GO:0006766
GeneOntologyCellularComponentendoplasmic reticulum membrane

UGT1A4 UGT1A1 UGT1A3 UGT1A6 NR3C2 UGT1A5

2.59e-041293166GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

UGT1A4 UGT1A1 UGT1A3 UGT1A6 NR3C2 UGT1A5

2.65e-041299166GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

UGT1A4 UGT1A1 UGT1A3 UGT1A6 NR3C2 UGT1A5

2.98e-041327166GO:0042175
DomainUDPGT

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

3.21e-1221155PF00201
DomainUDP_glucos_trans

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

3.21e-1221155IPR002213
DomainUDPGT

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

3.21e-1221155PS00375
Domain-

ZNF430 ZNF100 GZF1

1.57e-026791533.30.160.60
Domainzf-C2H2

ZNF430 ZNF100 GZF1

1.66e-02693153PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF430 ZNF100 GZF1

1.66e-02694153IPR013087
DomainZINC_FINGER_C2H2_2

ZNF430 ZNF100 GZF1

2.23e-02775153PS50157
DomainZINC_FINGER_C2H2_1

ZNF430 ZNF100 GZF1

2.24e-02777153PS00028
DomainZnf_C2H2-like

ZNF430 ZNF100 GZF1

2.39e-02796153IPR015880
DomainZnf_C2H2

ZNF430 ZNF100 GZF1

2.46e-02805153IPR007087
DomainZnF_C2H2

ZNF430 ZNF100 GZF1

2.49e-02808153SM00355
Domainzf-C2H2_6

ZNF100 GZF1

2.56e-02314152PF13912
PathwayREACTOME_GLUCURONIDATION

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

9.00e-1225125M17787
PathwayKEGG_ASCORBATE_AND_ALDARATE_METABOLISM

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

9.00e-1225125M605
PathwayWP_GLUCURONIDATION

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.11e-1126125M39404
PathwayKEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.66e-1128125M19580
PathwayKEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.26e-1041125M7399
PathwayREACTOME_ASPIRIN_ADME

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.83e-1044125M45014
PathwayKEGG_DRUG_METABOLISM_OTHER_ENZYMES

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

3.94e-1051125M17726
PathwayKEGG_STARCH_AND_SUCROSE_METABOLISM

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

4.35e-1052125M14171
PathwayKEGG_STEROID_HORMONE_BIOSYNTHESIS

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

5.82e-1055125M14933
PathwayKEGG_RETINOL_METABOLISM

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.27e-0964125M9488
PathwayREACTOME_HEME_DEGRADATION

UGT1A4 UGT1A1 UGT1A3 UGT1A5

1.45e-0920124MM14721
PathwayKEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.01e-0970125M16794
PathwayKEGG_DRUG_METABOLISM_CYTOCHROME_P450

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.32e-0972125M9257
PathwayREACTOME_GLUCURONIDATION

UGT1A4 UGT1A1 UGT1A3 UGT1A5

3.17e-0924124MM14599
PathwayWP_GLUCURONIDATION

UGT1A4 UGT1A1 UGT1A3 UGT1A5

3.77e-0925124MM15820
PathwayREACTOME_METABOLISM_OF_PORPHYRINS

UGT1A4 UGT1A1 UGT1A3 UGT1A5

1.07e-0832124MM14719
PathwayREACTOME_DRUG_ADME

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.91e-08109125M45012
PathwayREACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.91e-08109125M18788
PathwayREACTOME_ASPIRIN_ADME

UGT1A4 UGT1A1 UGT1A3 UGT1A5

4.40e-0845124MM15694
PathwayREACTOME_ATORVASTATIN_ADME

UGT1A4 UGT1A3 UGT1A5

2.13e-0715123MM15697
PathwayWP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.57e-07183125M39588
PathwayWP_ESTROGEN_METABOLISM_WP697

UGT1A1 UGT1A3 UGT1A6

3.82e-0718123M39424
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

6.41e-07220125M10320
PathwayWP_ESTROGEN_METABOLISM

UGT1A1 UGT1A3 UGT1A5

7.19e-0722123MM15888
PathwayREACTOME_PREDNISONE_ADME

UGT1A4 UGT1A3 UGT1A5

8.27e-0723123MM16639
PathwayREACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS

UGT1A4 UGT1A1 UGT1A3 UGT1A5

1.48e-06107124MM14595
PathwayWP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY

UGT1A4 UGT1A1 UGT1A6

2.09e-0631123M39476
PathwayREACTOME_DRUG_ADME

UGT1A4 UGT1A1 UGT1A3 UGT1A5

2.27e-06119124MM15692
PathwayWP_PREGNANE_X_RECEPTOR_PATHWAY

UGT1A4 UGT1A1 UGT1A6

2.31e-0632123M39567
PathwayWP_METAPATHWAY_BIOTRANSFORMATION

UGT1A4 UGT1A1 UGT1A3 UGT1A5

6.17e-06153124MM15844
PathwayWP_ARYL_HYDROCARBON_RECEPTOR_PATHWAY_WP2873

UGT1A4 UGT1A1 UGT1A6

6.55e-0645123M39615
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

UGT1A4 UGT1A1 UGT1A3 UGT1A5

2.54e-05219124MM14838
PathwayWP_CODEINE_AND_MORPHINE_METABOLISM

UGT1A1 UGT1A6

6.01e-0514122M39328
PathwayREACTOME_HEME_DEGRADATION

UGT1A4 UGT1A1

6.93e-0515122M27060
PathwayWP_NRF2_PATHWAY

UGT1A4 UGT1A1 UGT1A6

2.02e-04141123M39454
PathwayWP_2Q37_COPY_NUMBER_VARIATION_SYNDROME

UGT1A4 UGT1A1 UGT1A6

2.19e-04145123M45512
PathwayREACTOME_METABOLISM_OF_PORPHYRINS

UGT1A4 UGT1A1

2.30e-0427122M1088
PathwayREACTOME_PARACETAMOL_ADME

UGT1A1 UGT1A6

2.66e-0429122M45015
PathwayREACTOME_METABOLIC_DISORDERS_OF_BIOLOGICAL_OXIDATION_ENZYMES

UGT1A4 UGT1A1

3.67e-0434122M27461
PathwayWP_NUCLEAR_RECEPTORS_METAPATHWAY

UGT1A4 UGT1A1 UGT1A6

2.07e-03314123M39428
PathwayREACTOME_DISEASES_OF_METABOLISM

UGT1A4 UGT1A1

1.84e-02250122M27554
Pubmed

A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.30e-15916522511988
Pubmed

A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.30e-1591651339448
Pubmed

Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.59e-151016523642732
Pubmed

UDP-glucuronosyltransferases.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.59e-151016511465080
Pubmed

A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.59e-151016523371916
Pubmed

A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.59e-151016522558097
Pubmed

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

8.15e-151216519419973
Pubmed

Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

8.15e-151216511434514
Pubmed

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.32e-141316522085899
Pubmed

Genome-wide analysis of hepatic lipid content in extreme obesity.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.32e-141316525246029
Pubmed

Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.06e-141416521646302
Pubmed

Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.06e-141416514672974
Pubmed

The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.06e-14141659295054
Pubmed

Human UDP-glucuronosyltransferases: metabolism, expression, and disease.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.06e-141416510836148
Pubmed

Genome-wide association meta-analysis for total serum bilirubin levels.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

4.49e-141616519414484
Pubmed

Genome-wide association of serum bilirubin levels in Korean population.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

6.36e-141716520639394
Pubmed

A genome-wide assessment of variability in human serum metabolism.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.19e-131916523281178
Pubmed

Genetic determinants influencing human serum metabolome among African Americans.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

4.36e-132416524625756
Pubmed

Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population.

UGT1A4 UGT1A1 UGT1A3 UGT1A6

4.48e-13616419204906
Pubmed

Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry.

UGT1A4 UGT1A1 UGT1A3 UGT1A6

2.09e-12816422579593
Pubmed

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation.

UGT1A4 UGT1A1 UGT1A3 UGT1A6

2.09e-12816417179145
Pubmed

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro.

UGT1A4 UGT1A1 UGT1A3 UGT1A6

2.09e-12816420610558
Pubmed

Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis.

UGT1A4 UGT1A1 UGT1A3 UGT1A6

1.47e-111216418161889
Pubmed

Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans.

UGT1A4 UGT1A1 UGT1A3 UGT1A6

1.47e-111216420308471
Pubmed

Human metabolic individuality in biomedical and pharmaceutical research.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

4.26e-115716521886157
Pubmed

Isolation and characterization of a UDP-glucuronosyltransferase (UGT1A01) cloned from female rhesus monkey.

UGT1A1 UGT1A3 UGT1A5

7.99e-11316312051676
Pubmed

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

9.06e-116616519898482
Pubmed

Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8.

UGT1A4 UGT1A1 UGT1A3

3.19e-1041639535849
Pubmed

Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells.

UGT1A4 UGT1A1 UGT1A6

3.19e-1041631898728
Pubmed

Identification of an A-to-G missense mutation in exon 2 of the UGT1 gene complex that causes Crigler-Najjar syndrome type 2.

UGT1A4 UGT1A1 UGT1A6

3.19e-1041638276413
Pubmed

Mechanisms of inherited deficiencies of multiple UDP-glucuronosyltransferase isoforms in two patients with Crigler-Najjar syndrome, type I.

UGT1A4 UGT1A1 UGT1A6

3.19e-1041631634050
Pubmed

Genetic variations and haplotypes of UDP-glucuronosyltransferase 1A locus in a Korean population.

UGT1A4 UGT1A1 UGT1A5

3.19e-10416318223459
Pubmed

Identification of defect in the genes for bilirubin UDP-glucuronosyl-transferase in a patient with Crigler-Najjar syndrome type II.

UGT1A4 UGT1A1 UGT1A6

3.19e-1041638280139
Pubmed

Urinary excretion of phenytoin metabolites, 5-(4'-hydroxyphenyl)-5-phenylhydantoin and its O-glucuronide in humans and analysis of genetic polymorphisms of UDP-glucuronosyltransferases.

UGT1A4 UGT1A1 UGT1A6

3.19e-10416315855726
Pubmed

Isolation of cDNAs for mouse phenol and bilirubin UDP-glucuronosyltransferases and mapping of the mouse gene for phenol UDP-glucuronosyltransferase (Ugtla1) to chromosome 1 by restriction fragment length variations.

UGT1A1 UGT1A3 UGT1A5

7.98e-1051637677729
Pubmed

Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37.

UGT1A4 UGT1A1 UGT1A5

2.79e-0971638467709
Pubmed

Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p).

UGT1A1 UGT1A3 UGT1A5

2.79e-0971638464825
Pubmed

Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism.

UGT1A4 UGT1A1 UGT1A3

4.47e-09816312695355
Pubmed

An atlas of genetic influences on human blood metabolites.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.92e-0819016524816252
Pubmed

Discovery and refinement of loci associated with lipid levels.

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

3.24e-0821116524097068
Pubmed

Combined UGT1A1 and UGT1A6 genotypes together with a stressful life event increase breast cancer risk.

UGT1A1 UGT1A6

1.98e-07216220686835
Pubmed

Combined polymorphisms in UDP-glucuronosyltransferases 1A1 and 1A6: implications for patients with Gilbert's syndrome.

UGT1A1 UGT1A6

1.98e-07216212480553
Pubmed

Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability.

UGT1A4 UGT1A3

1.98e-07216224641623
Pubmed

Characterizing the effects of common UDP glucuronosyltransferase (UGT) 1A6 and UGT1A1 polymorphisms on cis- and trans-resveratrol glucuronidation.

UGT1A1 UGT1A6

1.98e-07216219406951
Pubmed

Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells.

UGT1A1 UGT1A6

1.98e-0721623141926
Pubmed

The development of UDP-glucuronosyltransferases 1A1 and 1A6 in the pediatric liver.

UGT1A1 UGT1A6

1.98e-07216221266593
Pubmed

Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

UGT1A3 UGT1A5

1.98e-0721628068691
Pubmed

Non tumoral hyperserotoninaemia responsive to octreotide due to dual polymorphism in UGT1A1 and UGT1A6.

UGT1A1 UGT1A6

1.98e-07216222450351
Pubmed

N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases.

UGT1A4 UGT1A3

1.98e-07216214570768
Pubmed

Exome-Wide Association Study Identifies New Low-Frequency and Rare UGT1A1 Coding Variants and UGT1A6 Coding Variants Influencing Serum Bilirubin in Elderly Subjects: A Strobe Compliant Article.

UGT1A1 UGT1A6

1.98e-07216226039129
Pubmed

Functional polymorphisms of UDP-glucuronosyltransferases 1A1, 1A6 and 1A8 are not involved in chronic pancreatitis.

UGT1A1 UGT1A6

5.95e-07316215247627
Pubmed

UGT1A1, UGT1A6 and UGT1A7 genetic analysis: repercussion for irinotecan pharmacogenetics in the São Miguel Island Population (Azores, Portugal).

UGT1A1 UGT1A6

5.95e-07316219712005
Pubmed

Glucuronidation of the nonsteroidal antiestrogen EM-652 (SCH 57068), by human and monkey steroid conjugating UDP-glucuronosyltransferase enzymes.

UGT1A1 UGT1A3

5.95e-07316211179460
Pubmed

Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy--an extended haplotype of genetic variants increases risk in indinavir treatment.

UGT1A1 UGT1A3

5.95e-07316219303655
Pubmed

Linkage disequilibrium of UGT1A1 *6 and UGT1A1 *28 in relation to UGT1A6 and UGT1A7 polymorphisms.

UGT1A1 UGT1A6

5.95e-07316216969497
Pubmed

Frequent co-occurrence of the TATA box mutation associated with Gilbert's syndrome (UGT1A1*28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7*3) in Caucasians and Egyptians.

UGT1A1 UGT1A6

5.95e-07316212732365
Pubmed

Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4.

UGT1A4 UGT1A3

5.95e-07316223611809
Pubmed

A role for UDP-glucose glycoprotein glucosyltransferase in expression and quality control of MHC class I molecules.

UGT1A3 UGT1A5

5.95e-07316221383159
Pubmed

Phase II study of a triplet regimen of S-1 combined with irinotecan and oxaliplatin in patients with metastatic gastric cancer: clinical and pharmacogenetic results.

UGT1A1 UGT1A6

5.95e-07316220860988
Pubmed

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor.

UGT1A3 UGT1A5

1.19e-06416212644700
Pubmed

Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants.

UGT1A1 UGT1A6

1.19e-06416224255116
Pubmed

Chromosomal mapping of a human phenol UDP-glucuronosyltransferase, GNT1.

UGT1A1 UGT1A6

1.19e-0641622108603
Pubmed

Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue.

UGT1A4 UGT1A3

1.19e-0641629271343
Pubmed

Coimmunoprecipitation of UDP-glucuronosyltransferase isoforms and cytochrome P450 3A4.

UGT1A1 UGT1A6

1.19e-06416215486048
Pubmed

Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4.

UGT1A4 UGT1A3

1.98e-06516215057901
Pubmed

Drug-Metabolizing Activity, Protein and Gene Expression of UDP-Glucuronosyltransferases Are Significantly Altered in Hepatocellular Carcinoma Patients.

UGT1A4 UGT1A1

1.98e-06516226010150
Pubmed

Genetic polymorphisms of drug-metabolizing enzymes and anti-TB drug-induced hepatitis.

UGT1A1 UGT1A3

4.16e-06716219891553
Pubmed

Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine.

UGT1A1 UGT1A3

5.55e-06816210748067
Pubmed

Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms.

UGT1A1 UGT1A3

5.55e-06816218052087
Pubmed

The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases.

UGT1A1 UGT1A3

5.55e-06816218719240
Pubmed

Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States.

UGT1A1 UGT1A3

5.55e-06816220142249
Pubmed

Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk.

UGT1A1 UGT1A6

5.55e-06816215319294
Pubmed

Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients.

UGT1A1 UGT1A6

1.09e-051116218695635
Pubmed

Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women.

UGT1A1 UGT1A6

2.69e-051716219424794
Pubmed

Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples.

UGT1A1 UGT1A3

3.02e-051816220056724
Pubmed

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.

PRICKLE1 DTX1 NR3C2

8.93e-0519316322589738
Pubmed

Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.

UGT1A1 UGT1A6

1.17e-043516218992148
Pubmed

Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma.

UGT1A3 UGT1A5

3.46e-046016231220272
Pubmed

Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients.

UGT1A1 UGT1A6

4.18e-046616220679960
InteractionUGT1A3 interactions

UGT1A3 UGT1A5

5.16e-065152int:UGT1A3
InteractionUGT1A5 interactions

UGT1A3 UGT1A5

4.68e-0514152int:UGT1A5
InteractionCYP3A4 interactions

UGT1A1 UGT1A6

6.99e-0517152int:CYP3A4
InteractionABT1 interactions

ZNF430 ZNF100 GZF1 FAM111A

2.17e-04423154int:ABT1
InteractionZNF467 interactions

NKTR ZNF100 GZF1

2.90e-04179153int:ZNF467
InteractionPURG interactions

NKTR GZF1 FAM111A

5.51e-04223153int:PURG
Cytoband2q37

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

4.35e-13311652q37
CytobandEnsembl 112 genes in cytogenetic band chr2q37

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.16e-08226165chr2q37
Cytoband19p12

ZNF430 ZNF100

4.48e-049016219p12
CytobandEnsembl 112 genes in cytogenetic band chr19p12

ZNF430 ZNF100

8.20e-04122162chr19p12
GeneFamilyUDP glucuronosyltransferases

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

5.74e-1232115363
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF430 ZNF100 GZF1

8.10e-0371811328
CoexpressionNFE2L2.V2

UGT1A4 UGT1A1 UGT1A3 ZNF430 UGT1A6 UGT1A5

1.39e-07469156M2870
CoexpressionBERENJENO_TRANSFORMED_BY_RHOA_REVERSIBLY_UP

UGT1A3 UGT1A5

3.65e-0516152MM1089
ToppCellnucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

UGT1A4 UGT1A1 UGT1A6

3.23e-05177163cbad1a23851151dbef01ea2af960e6f0944f838b
ToppCellnucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

UGT1A4 UGT1A1 UGT1A6

3.23e-05177163ce86dfaeb74d995a19aea62f0fb15c4c0bb854b0
ToppCellCOVID-19-Epithelial_cells-Airway_basal|COVID-19 / group, cell type (main and fine annotations)

UGT1A1 UGT1A3 UGT1A6

3.80e-051871638407a82e98f56a94ea26562bcb6bbe00a8f41661
DrugAC1MRQNQ

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

7.41e-159155CID003522271
DrugChebi:32663

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

7.41e-159155CID005460873
Drug3-iodophenol

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

7.41e-159155CID000012272
DrugAC1L4J7U

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

7.41e-159155CID000186631
DrugDHPASiU

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

7.41e-159155CID000197602
Drug4-nitrophenyl)imidazole

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.72e-1411155CID000123155
DrugAC1O5XMV

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.72e-1411155CID006442661
DrugAC1Q6OQG

UGT1A4 UGT1A1 UGT1A3 UGT1A6 NR3C2 UGT1A5

2.84e-1433156CID000009686
DrugN-OH-DABZ

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

4.65e-1412155CID000051366
Drug7,7,7-triphenylheptanoic acid

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

4.65e-1412155CID000276709
Drugnonanoyl-N-methylglucamide

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

4.65e-1412155CID000160090
Drug1-O-beta-D-glucopyranosyl-D-mannitol

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

4.65e-1412155CID000088735
Drug2,4,6-TCB

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

4.65e-1412155CID000037247
Drugtritanol

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

7.56e-1413155CID000006457
Drug5-azido-UDP-glucuronic acid

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

7.56e-1413155CID003081279
Drugcotinine-N-glucuronide

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

7.56e-1413155CID000000411
Drugpropranolol glucuronide

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.18e-1314155CID000119515
DrugPCB-61

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.18e-1314155CID000036401
Drugsulforaphane nitrile

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.76e-1315155CID000543743
Drugafloqualone

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.76e-1315155CID000002040
Drug2,2',3,5,5'-pentachlorobiphenyl

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.76e-1315155CID000040469
Drugcoumarin-3-carboxylic acid

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.76e-1315155CID000010752
Drugnaphthyl sulphate

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.76e-1315155CID000114775
Drug1'-hydroxyestragole

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.56e-1316155CID000040003
Drugbilirubin-phosphate

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.56e-1316155CID005497144
Drugquercetin-3,4'-diglucoside

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.56e-1316155CID005320835
Drug3 beta,5 alpha,25R)- 3-hydroxyspirostan-12-one

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

3.63e-1317155CID000003573
Drug6-hydroxychrysene

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

3.63e-1317155CID000037766
DrugApApG

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

5.02e-1318155CID003081975
DrugC1 11-32

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

5.02e-1318155CID000443077
DrugC11131

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

5.02e-1318155CID000443076
DrugSureCN12722713

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

5.02e-1318155CID005488034
Drug2,3,7-trichlorodibenzo-p-dioxin

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

5.02e-1318155CID000036614
Drugethyl-beta-D-6-glucosiduronic acid

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

5.02e-1318155CID000152226
DrugBr 2

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

5.02e-1318155CID003060900
Drugalmokalant

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

6.82e-1319155CID003033962
Drug9-OH-risperidone

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

6.82e-1319155CID000475100
Drug5alpha-spirostan-3beta-ol

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

6.82e-1319155CID000091433
DrugAC1Q6OQF

UGT1A4 UGT1A1 UGT1A3 UGT1A6 NR3C2 UGT1A5

7.38e-1355156CID000009685
DrugAC1L1OBF

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

9.09e-1320155CID000032736
Drugtectochrysin

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

9.09e-1320155CID005281954
Drug4'-hydroxydiclofenac

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

9.09e-1320155CID000116545
Drugestriol-16-glucuronide

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.19e-1221155CID000122281
DrugBenzamidoxime hydrochloride

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.19e-1221155CID000069186
Drugdulcin

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.19e-1221155CID000009013
Drugamonafide

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.54e-1222155CID000050515
DrugN-methylpiperazine

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.54e-1222155CID000053167
Drug2-hydroxyestradiol

UGT1A4 UGT1A1 UGT1A3 UGT1A6 NR3C2 UGT1A5

1.73e-1263156CID000009684
Drugestradiol-3-glucuronide

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.97e-1223155CID000066651
Drugphenanthridine

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.97e-1223155CID000009189
Drugamidoxime

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.97e-1223155CID000465967
DrugAS-3201

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.49e-1224155CID000153948
DrugN-acetylbenzidine

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

3.11e-1225155CID000018787
Drug5,6-benzoquinoline

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

3.11e-1225155CID000006796
Drug5-MOP

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

3.11e-1225155CID000002355
DrugN-phenylmaleimide

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

3.11e-1225155CID000013662
DrugAzMC

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

3.11e-1225155CID000064986
DrugDiMeIQx

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

4.72e-1227155CID000104739
Drugdiflunisal

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

4.72e-1227155CID000003059
DrugH-Ni

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

5.74e-1228155CID000445665
DrugCARMINE

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

5.74e-1228155CID000014749
DrugN-hydroxy-4-aminobiphenyl

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

5.74e-1228155CID000081261
Drugerucin

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

5.74e-1228155CID000078160
Drug7-hydroxy-4-trifluoromethylcoumarin

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

6.94e-1229155CID005375667
DrugAC1L1JAL

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

6.94e-1229155CID000004954
Drug7-hydroxycoumarin glucuronide

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

6.94e-1229155CID000125641
Drugiberin

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

6.94e-1229155CID000010455
Drugtrans-3'-hydroxycotinine

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

6.94e-1229155CID000000414
Drugparicalcitol

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

8.32e-1230155CID005281104
DrugAC1L9E0Q

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

8.32e-1230155CID000443095
Drugdihydroartemisinin

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

8.32e-1230155CID000107770
Drugtolcapone

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

8.32e-1230155CID004659569
Drug4-ethylphenol

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

9.92e-1231155CID000031242
DrugPCB 156

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

9.92e-1231155CID000038019
Drug4'-HPPH

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

9.92e-1231155CID000017732
DrugMuracein C

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.17e-1132155CID003086323
DrugNNAL

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.17e-1132155CID000104856
Drugindole-2-carboxylic acid

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.17e-1132155CID000072899
Drug6-methylsalicylic acid

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.38e-1133155CID000011279
Drugnorbuprenorphine

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.38e-1133155CID000114976
Druggeniposide

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.38e-1133155CID000107848
DrugBP-3,6-quinol

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.38e-1133155CID000119292
DrugR(-)-Denopamine

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.38e-1133155CID000003818
Drugestragole

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.62e-1134155CID000008815
Drug3-[(3S,5R,10S,13R,14S,17R)-3-[(2S,4R,5R,6S)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.89e-1135155CID010436171
DrugAC1NOWCJ

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.89e-1135155CID005120112
Drugestrone-3-glucuronide

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.89e-1135155CID000115255
Drugglucoraphanin

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.20e-1136155CID000656556
DrugAC1L9DGV

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.20e-1136155CID000417381
Druganisole

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.20e-1136155CID000007519
Drugbevirimat

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.20e-1136155CID000457928
Drugmuraglitazar

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.20e-1136155CID000206044
Drug6beta-hydroxytestosterone

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.54e-1137155CID000065543
DrugN-Fg

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.54e-1137155CID000445227
Drugl-borneol

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.54e-1137155CID000010049
Drugacotiamide

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.54e-1137155CID005282338
Drug4-methylumbelliferyl glucuronide

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.92e-1138155CID000091553
Drugx Me

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.92e-1138155CID009600424
Drugacacetin

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.92e-1138155CID005280442
Drug1-phenylimidazole

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

3.35e-1139155CID000081595
DiseaseX-11442 measurement

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.35e-159145EFO_0021236
DiseaseX-11441 measurement

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.35e-159145EFO_0021235
Diseasecirculating cell free DNA measurement

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.35e-159145EFO_0004739
Diseasebilirubin measurement, response to xenobiotic stimulus

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.35e-159145EFO_0004570, GO_0009410
DiseaseUDP-glucuronosyltransferase 1-6 measurement

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.70e-1510145EFO_0802185
Diseasebilirubin measurement, response to tenofovir

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

2.70e-1510145EFO_0004570, EFO_0009279
Diseaseinsomnia, bilirubin measurement

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

4.96e-1511145EFO_0004570, EFO_0004698
Diseasehistidine betaine (hercynine) measurement

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

4.96e-1511145EFO_0800972
Diseasealdosterone measurement

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

4.96e-1511145EFO_0010219
DiseaseX-21796 measurement

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

4.96e-1511145EFO_0800825
Diseasebiliverdin measurement

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

8.49e-1512145EFO_0021033
Diseaselow density lipoprotein cholesterol measurement, body fat percentage

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

6.63e-1417145EFO_0004611, EFO_0007800
Diseasexanthurenate measurement

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.27e-1229145EFO_0010551
Diseaseresponse to dolutegravir

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.52e-1230145EFO_0600017
DiseaseX-11793--oxidized bilirubin measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

2.22e-128144EFO_0021260
DiseaseSuccinimide measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

2.22e-128144EFO_0022118
DiseaseX-24849 measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

2.22e-128144EFO_0800909
Diseasecholelithiasis, bilirubin measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

2.22e-128144EFO_0004570, EFO_0004799
DiseaseX-11530 measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

2.22e-128144EFO_0021249
DiseaseX-11522 measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

2.22e-128144EFO_0800696
DiseaseX-10458 measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

2.22e-128144EFO_0800692
Diseasemembrane-associated progesterone receptor component 1 measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

2.22e-128144EFO_0802740
DiseaseX-16946 measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

2.22e-128144EFO_0800766
Diseasesulfate of piperine metabolite C16H19NO3 (2) measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

2.22e-128144EFO_0801034
DiseaseX-11880 measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

3.99e-129144EFO_0800698
Diseaseprotein-tyrosine kinase 6 measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

3.99e-129144EFO_0020691
Diseasesulfate of piperine metabolite C18H21NO3 (3) measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

3.99e-129144EFO_0801037
Diseasetestis-specific chromodomain protein Y 1 measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

3.99e-129144EFO_0802127
Diseasesulfate of piperine metabolite C18H21NO3 (1) measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

3.99e-129144EFO_0801036
DiseaseX-21448 measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

6.65e-1210144EFO_0800816
DiseaseX-23974 measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

6.65e-1210144EFO_0800867
Diseasep-cresol glucuronide measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

1.57e-1112144EFO_0800079
Diseaseretinol dehydrogenase 16 measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

2.26e-1113144EFO_0802007
Diseaseurate measurement, spine bone mineral density

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

4.86e-1158145EFO_0004531, EFO_0007701
Diseaseangiopoietin-related protein 1 measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

9.66e-1118144EFO_0801382
Diseasetissue factor measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

1.89e-1021144EFO_0010623
Diseasecholelithiasis

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

4.12e-1088145EFO_0004799
Diseasegallstones

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.17e-09108145EFO_0004210
Diseasepregnenetriol sulfate measurement

UGT1A4 UGT1A6 UGT1A5

1.40e-0811143EFO_0800586
Diseaseplasma N-desmethylclozapine measurement

UGT1A4 UGT1A6 UGT1A5

1.40e-0811143EFO_0600039
Diseasepregnenetriol disulfate measurement

UGT1A4 UGT1A6 UGT1A5

2.42e-0813143EFO_0800587
Diseasethyroxine measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

5.70e-0883144EFO_0005130
DiseaseX-21441 measurement

UGT1A4 UGT1A6 UGT1A5

5.76e-0817143EFO_0800814
Diseasehormone measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

5.98e-0884144EFO_0004730
Diseasebilirubin measurement

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.32e-06442145EFO_0004570
Diseasemetabolite measurement

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

4.20e-06560145EFO_0004725
Diseaseserum N-desmethylclozapine measurement

UGT1A6 UGT1A5

5.84e-068142EFO_0600043
Diseaseplasma clozapine measurement

UGT1A6 UGT1A5

5.84e-068142EFO_0600038
Diseasenon-high density lipoprotein cholesterol measurement

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

1.36e-05713145EFO_0005689
Diseaseserum metabolite measurement

UGT1A4 UGT1A1 UGT1A3 UGT1A6 UGT1A5

5.24e-05945145EFO_0005653
Diseasehepatitis B (is_implicated_in)

UGT1A1 UGT1A6

1.38e-0437142DOID:2043 (is_implicated_in)
Diseasevitamin D deficiency

UGT1A6 UGT1A5

1.38e-0437142EFO_0003762
Diseaseapolipoprotein B measurement

UGT1A4 UGT1A3 UGT1A6 UGT1A5

2.11e-04663144EFO_0004615
Diseasevitamin D measurement, COVID-19

UGT1A6 UGT1A5

2.43e-0449142EFO_0004631, MONDO_0100096
Diseasevitamin D measurement

UGT1A4 UGT1A6 UGT1A5

4.85e-04336143EFO_0004631

Protein segments in the cluster

PeptideGeneStartEntry
RKCLGKKGRVKKAHK

UGT1A3

516

P35503
LCGKKFKRKKDVKRH

GZF1

381

Q9H116
GARKSKKLGKLKGIH

NR3C2

671

P08235
SAGCRKGKHKRKKLP

PER3

731

P56645
GVCRKTKKKHLKKSK

DTX1

376

Q86Y01
KSKKKKGHKGKNCII

PRICKLE1

816

Q96MT3
RRIVKCGKLHKKGRK

FAM111A

196

Q96PZ2
HHFKRKRGKKKGKIL

MIGA1

91

Q8NAN2
VKHKKKGKKQKHCRR

NKTR

436

P30414
KGKKQKHCRRHKQTK

NKTR

441

P30414
KIRHTRKKPFKCKKC

ZNF100

196

Q8IYN0
KCLGKKGRVKKAHKS

UGT1A1

516

P22309
RKCLGKKGRVKKAHK

UGT1A5

516

P35504
KHCKLKKKSKEEGAR

TEX50

161

A0A1B0GTY4
KIRHTGKKPFKCKKC

ZNF430

196

Q9H8G1
CLGKKGRVKKAHKSK

UGT1A6

516

P19224
RKCLGKKGRVKKAHK

UGT1A4

516

P22310