Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	organophosphate metabolic process	CS SAMD8 PIK3C3 TK2 FDFT1 CDS2 PIP4K2A ACSF3 PGAP4 ABCD1 PIGG PLCG2 HACD2 GALR2 AK7 SDHA SACM1L CASK	2.11e-06	1142	91	18	GO:0019637
GeneOntologyBiologicalProcess	lipid biosynthetic process	CERK ACER3 SAMD8 PIK3C3 FDFT1 CDS2 PIP4K2A ACSF3 PGAP4 ABCD1 PIGG PLCG2 HACD2 CERS1 SACM1L	2.54e-06	813	91	15	GO:0008610
GeneOntologyBiologicalProcess	organophosphate biosynthetic process	SAMD8 PIK3C3 TK2 CDS2 PIP4K2A ACSF3 PGAP4 PIGG PLCG2 HACD2 AK7 SDHA SACM1L	4.87e-06	644	91	13	GO:0090407
GeneOntologyBiologicalProcess	membrane lipid biosynthetic process	CERK ACER3 SAMD8 PGAP4 PIGG HACD2 CERS1	6.13e-06	157	91	7	GO:0046467
GeneOntologyBiologicalProcess	phosphatidylinositol metabolic process	PIK3C3 PIP4K2A PGAP4 PIGG PLCG2 GALR2 SACM1L	1.03e-05	170	91	7	GO:0046488
GeneOntologyBiologicalProcess	phospholipid metabolic process	SAMD8 PIK3C3 FDFT1 CDS2 PIP4K2A PGAP4 PIGG PLCG2 GALR2 SACM1L	1.32e-05	410	91	10	GO:0006644
GeneOntologyBiologicalProcess	phospholipid biosynthetic process	SAMD8 PIK3C3 CDS2 PIP4K2A PGAP4 PIGG PLCG2 SACM1L	2.45e-05	268	91	8	GO:0008654
GeneOntologyBiologicalProcess	phosphatidylinositol biosynthetic process	PIK3C3 PIP4K2A PGAP4 PIGG PLCG2 SACM1L	2.62e-05	132	91	6	GO:0006661
GeneOntologyBiologicalProcess	glycerophospholipid biosynthetic process	PIK3C3 CDS2 PIP4K2A PGAP4 PIGG PLCG2 SACM1L	4.96e-05	217	91	7	GO:0046474
GeneOntologyBiologicalProcess	membrane lipid metabolic process	CERK ACER3 SAMD8 PGAP4 PIGG HACD2 CERS1	6.96e-05	229	91	7	GO:0006643
GeneOntologyBiologicalProcess	glycerophospholipid metabolic process	PIK3C3 CDS2 PIP4K2A PGAP4 PIGG PLCG2 GALR2 SACM1L	8.55e-05	320	91	8	GO:0006650
GeneOntologyBiologicalProcess	sphingolipid biosynthetic process	CERK ACER3 SAMD8 HACD2 CERS1	1.70e-04	117	91	5	GO:0030148
GeneOntologyBiologicalProcess	glycerolipid biosynthetic process	PIK3C3 CDS2 PIP4K2A PGAP4 PIGG PLCG2 SACM1L	1.85e-04	268	91	7	GO:0045017
GeneOntologyBiologicalProcess	positive regulation of AMPA receptor activity	RELN SHANK3	1.91e-04	5	91	2	GO:2000969
GeneOntologyBiologicalProcess	neuron projection organization	RELN ABCD1 DCTN1 SHANK3 CASK	2.49e-04	127	91	5	GO:0106027
GeneOntologyBiologicalProcess	positive regulation of dendritic spine development	RELN CREBBP SHANK3 CASK	2.60e-04	70	91	4	GO:0060999
GeneOntologyBiologicalProcess	NMDA glutamate receptor clustering	RELN SHANK3	2.85e-04	6	91	2	GO:0097114
GeneOntologyBiologicalProcess	amide metabolic process	CERK CS ACER3 SAMD8 SLC19A1 ACSF3 ABCD1 HACD2 CERS1	4.24e-04	511	91	9	GO:0043603
Pathway	REACTOME_METABOLISM_OF_LIPIDS	CERK ACER3 SAMD8 PIK3C3 FDFT1 CDS2 PIP4K2A ACSF3 ABCD1 HACD2 CERS1 MORC2 SACM1L	9.55e-06	620	70	13	MM15193
Pathway	REACTOME_METABOLISM_OF_LIPIDS	CERK ACER3 SAMD8 PIK3C3 FDFT1 CDS2 PIP4K2A ACSF3 ABCD1 HACD2 CERS1 MORC2 CREBBP SACM1L	1.72e-05	757	70	14	M27451
Pathway	WP_PHOSPHOINOSITIDES_METABOLISM	PIK3C3 PIP4K2A PLCG2 SACM1L	9.98e-05	49	70	4	M40046
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	FDFT1 ALG9 UBXN8 CPD HACD2 CERS1 NCLN SMCR8 RUSF1 SACM1L	4.77e-07	468	92	10	31056421
Pubmed	The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity.	FDFT1 ACSF3 PIGG MFSD5	3.51e-06	39	92	4	23864651
Pubmed	CASK and its target gene Reelin were co-upregulated in human esophageal carcinoma.	RELN CASK	6.92e-06	2	92	2	11880184
Pubmed	Identification and characterization of versican/PG-M aggregates in cartilage.	ACAN VCAN	6.92e-06	2	92	2	16648631
Pubmed	Cleavage of the carboxyl tail from the G3 domain of aggrecan but not versican and identification of the amino acids involved in the degradation.	ACAN VCAN	6.92e-06	2	92	2	11932252
Pubmed	HECTD2/TNFAIP1 Axis Regulating the p38/JNK Pathway to Promote an Inflammatory Response in Renal Cell Carcinoma Cells.	HECTD2 TNFAIP1	6.92e-06	2	92	2	38688591
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	PSMD6 CUL1 CS NOP56 UTP15 KIAA1217 PUSL1 ACSF3 CPD SPAG9 HUWE1 NCLN SMCR8 SDHA CASK	8.64e-06	1496	92	15	32877691
Pubmed	Defining the membrane proteome of NK cells.	NOP56 PIK3C3 PRF1 ALG9 CDS2 CPD ABCD1 PIGG HUWE1 NCLN DCTN1 MFSD5 RUSF1	1.24e-05	1168	92	13	19946888
Pubmed	Distinct interaction of versican/PG-M with hyaluronan and link protein.	ACAN VCAN	2.07e-05	3	92	2	12888576
Pubmed	Link protein has greater affinity for versican than aggrecan.	ACAN VCAN	2.07e-05	3	92	2	14724283
Pubmed	Topographical variation in the distributions of versican, aggrecan and perlecan in the foetal human spine reflects their diverse functional roles in spinal development.	ACAN VCAN	2.07e-05	3	92	2	19669783
Pubmed	Expression and purification of functionally active hyaluronan-binding domains from human cartilage link protein, aggrecan and versican: formation of ternary complexes with defined hyaluronan oligosaccharides.	ACAN VCAN	2.07e-05	3	92	2	15590670
Pubmed	In situ hybridization and immunohistochemistry of versican, aggrecan and link protein, and histochemistry of hyaluronan in the developing mouse limb bud cartilage.	ACAN VCAN	2.07e-05	3	92	2	14620382
Pubmed	Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection.	ACAN VCAN	2.07e-05	3	92	2	29515038
Pubmed	A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport.	PIK3C3 DCTN1	2.07e-05	3	92	2	25533844
Pubmed	Fibulin-1 is a ligand for the C-type lectin domains of aggrecan and versican.	ACAN VCAN	2.07e-05	3	92	2	10400671
Pubmed	Plcγ2/Tmem178 dependent pathway in myeloid cells modulates the pathogenesis of cytokine storm syndrome.	PRF1 PLCG2	4.14e-05	4	92	2	30879886
Pubmed	Lecticans: organizers of the brain extracellular matrix.	ACAN VCAN	4.14e-05	4	92	2	10766023
Pubmed	Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla.	ACAN VCAN	4.14e-05	4	92	2	21584905
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	PSMD6 ZNF12 NOP56 PIK3C3 APOBEC3C HUWE1 LONRF3 CASK	5.28e-05	496	92	8	31343991
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	PSMD6 NOP56 PIP4K2A DOCK7 SPAG9 HUWE1 MORC2 SPEN CREBBP	5.43e-05	645	92	9	25281560
Pubmed	The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding.	ACAN VCAN	6.89e-05	5	92	2	11038354
Pubmed	Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain.	RELN VCAN	6.89e-05	5	92	2	9716537
Pubmed	Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation.	CUL1 CREBBP	6.89e-05	5	92	2	17015689
Pubmed	FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation.	CUL1 PIK3C3	6.89e-05	5	92	2	25593308
Pubmed	Single nucleotide polymorphisms in succinate dehydrogenase subunits and citrate synthase genes: association results for impaired spermatogenesis.	CS SDHA	6.89e-05	5	92	2	17298551
Pubmed	During embryogenesis, esrp1 expression is restricted to a subset of epithelial cells and is associated with splicing of a number of developmentally important genes.	DOCK7 CASK	6.89e-05	5	92	2	23233200
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	FDFT1 ALG9 KDELR1 PGAP4 CPD PIGG HACD2 CERS1 NCLN MFSD5 RUSF1 SACM1L	7.75e-05	1201	92	12	35696571
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	PSMD6 ZNF12 ZNF845 FDFT1 ALG9 RBAK DOCK7 CPD ABCD1 NCLN RUSF1 SACM1L	7.87e-05	1203	92	12	29180619
Pubmed	Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.	PSMD6 CUL1 SPAG9 HUWE1	7.88e-05	85	92	4	19596235
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	CUL1 A2ML1 PUSL1 SPAG9 HUWE1 MORC2 SPEN DCTN1 CREBBP SACM1L	9.13e-05	857	92	10	25609649
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	PSMD6 CUL1 CS SF3B3 NOP56 UTP15 DOCK7 HUWE1 NCLN SPEN DCTN1 SDHA SACM1L	9.55e-05	1425	92	13	30948266
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	PSMD6 CS SF3B3 KIAA1217 VCAN PIP4K2A RBP3 DOCK7 DCTN1 SHANK3 SDHA SACM1L CASK	9.96e-05	1431	92	13	37142655
Pubmed	Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues.	ACAN VCAN	1.03e-04	6	92	2	19250981
Pubmed	Over-expression of the chondroitin sulphate proteoglycan versican is associated with defective neural crest migration in the Pax3 mutant mouse (splotch).	ACAN VCAN	1.03e-04	6	92	2	9486530
Pubmed	Next-generation sequencing identifies the Danforth's short tail mouse mutation as a retrotransposon insertion affecting Ptf1a expression.	KIAA1217 PIP4K2A	1.03e-04	6	92	2	23437000
Pubmed	The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers.	CUL1 SEMG1 DCTN1	1.20e-04	36	92	3	23658844
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	CUL1 ALG9 CDS2 PUSL1 PGAP4 PIGG HACD2 CERS1 SACM1L	1.24e-04	719	92	9	35337019
Pubmed	Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.	KDELR1 DOCK7 PGAP4 PIGG HACD2 CERS1	1.39e-04	296	92	6	34186245
Pubmed	Androgen upregulates NR4A1 via the TFAP2A and ETS signaling networks.	FLI1 KCNH2	1.44e-04	7	92	2	31146003
Pubmed	Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors.	ACAN VCAN	1.44e-04	7	92	2	21976490
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	RELN CS MTA3 HECTD2 ANKRD49 SESN3 ANKRD24 HUWE1 DCTN1 CREBBP SDHA CASK	1.46e-04	1285	92	12	35914814
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	PSMD6 CUL1 FLI1 ZNF845 MTA3 RBAK MORC2 TTC9C ZBTB3 SPEN CREBBP	1.60e-04	1103	92	11	34189442
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	CUL1 SF3B3 KIAA1217 PIP4K2A ANKRD49 HUWE1 SPEN CREBBP	1.71e-04	588	92	8	38580884
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	ZNF12 CS NOP56 ABCD1 PLCG2 MORC2 DCTN1 CREBBP SDHA	1.76e-04	754	92	9	35906200
Pubmed	Housekeeping genes for phylogenetic analysis of eutherian relationships.	CS SDHA	1.92e-04	8	92	2	16751257
Pubmed	Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice.	RELN ACAN	1.92e-04	8	92	2	11856531
Pubmed	K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression.	HUWE1 CREBBP	1.92e-04	8	92	2	27934968
Pubmed	Promoter occupancy of MLL1 histone methyltransferase seems to specify the proliferative and apoptotic functions of E2F1 in a tumour microenvironment.	CUL1 CREBBP	1.92e-04	8	92	2	23868976
Pubmed	Regulation of Cullin-RING ubiquitin ligase 1 by Spliceosome-associated protein 130 (SAP130).	CUL1 SF3B3	1.92e-04	8	92	2	23951410
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	SLC19A1 FDFT1 CPD ABCD1 HACD2 HUWE1 CERS1 NCLN SDHA SACM1L	1.97e-04	942	92	10	31073040
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	SF3B3 DOCK7 CPD PIGG DCTN1	2.05e-04	202	92	5	24639526
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	PSMD6 CS KIAA1217 DOCK7 SNRK TNFAIP1 HUWE1 NCLN SHANK3 SDHA SACM1L	2.11e-04	1139	92	11	36417873
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	CS SF3B3 NOP56 FDFT1 HUWE1 DCTN1 SDHA SACM1L	2.12e-04	607	92	8	39147351
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZNF12 FLI1 ZNF845 MTA3 RBAK KDELR1 MORC2 SPEN	2.14e-04	608	92	8	36089195
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	CUL1 SF3B3 FDFT1 PRF1 CPD HUWE1 NCLN SDHA	2.26e-04	613	92	8	22268729
Pubmed	Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.	RELN KCNH2 PLCG2	2.35e-04	45	92	3	25979088
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CUL1 CS SF3B3 NOP56 UTP15 PIP4K2A A2ML1 APOBEC3C PLCG2 HUWE1 DCTN1 CREBBP	2.35e-04	1353	92	12	29467282
Pubmed	Linkage and candidate gene studies of autism spectrum disorders in European populations.	RELN SHANK3	2.46e-04	9	92	2	20442744
Pubmed	Radial glia regulate Cajal-Retzius cell positioning in the early embryonic cerebral cortex.	RELN ACAN	2.46e-04	9	92	2	21185282
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	PSMD6 SEMG1 PUSL1 CPD SPAG9 HUWE1 NCLN PPEF1 SDHA CASK	2.57e-04	974	92	10	28675297
Pubmed	N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.	ZNF846 SNRK SPAG9 TNFAIP1 SLC45A4	2.86e-04	217	92	5	34048709
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	PSMD6 CUL1 CS SF3B3 NOP56 DOCK7 DCTN1 SDHA CASK	2.96e-04	809	92	9	32129710
Pubmed	PI(5)P regulates autophagosome biogenesis.	PIK3C3 PIP4K2A	3.07e-04	10	92	2	25578879
Pubmed	High-resolution genetic, physical, and transcript map of the mnd2 region of mouse chromosome 6.	M1AP DCTN1	3.07e-04	10	92	2	9806835
Pubmed	Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate.	KCNH2 KCNH4	3.07e-04	10	92	2	26503718
Pubmed	Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.	CS CDS2 SDHA	3.21e-04	50	92	3	26058080
Pubmed	Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.	PSMD6 CUL1 SF3B3 SPAG9 TNFAIP1 HUWE1 DCTN1	3.51e-04	495	92	7	28581483
Pubmed	Hacd2 deficiency in mice leads to an early and lethal mitochondrial disease.	CS HACD2	3.75e-04	11	92	2	36693621
Pubmed	Versican facilitates chondrocyte differentiation and regulates joint morphogenesis.	ACAN VCAN	3.75e-04	11	92	2	20404343
Pubmed	ApoER2 Controls Not Only Neuronal Migration in the Intermediate Zone But Also Termination of Migration in the Developing Cerebral Cortex.	RELN ACAN	3.75e-04	11	92	2	27909010
Pubmed	Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.	CUL1 CREBBP	3.75e-04	11	92	2	24349473
Pubmed	Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development.	ACAN VCAN	3.75e-04	11	92	2	38750698
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	PSMD6 CUL1 SF3B3 NOP56 FDFT1 DOCK7 PGAP4 PIGG HUWE1 NCLN SDHA SACM1L	4.12e-04	1440	92	12	30833792
Pubmed	Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.	HUWE1 SMCR8 DCTN1	4.49e-04	56	92	3	27103069
Pubmed	miRNAs control tracheal chondrocyte differentiation.	ACAN SPEN	4.49e-04	12	92	2	21945074
Pubmed	Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart.	ACAN VCAN	4.49e-04	12	92	2	18296617
Pubmed	SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release.	CUL1 CASK	4.49e-04	12	92	2	17803915
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	CS SAMD8 KDELR1 CPD SPAG9 HACD2 HUWE1 PCDHGC3 MFSD5 RUSF1	5.03e-04	1061	92	10	33845483
Pubmed	Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth.	ACAN VCAN	5.30e-04	13	92	2	32909945
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	SF3B3 NOP56 UTP15 SLC19A1 FDFT1 UBXN8 CPD NCLN SMCR8 DCTN1 SDHA CASK	5.49e-04	1487	92	12	33957083
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	PSMD6 CUL1 SF3B3 NOP56 PIK3C3 FDFT1 KDELR1 SNRK SPAG9 APOBEC3C DCTN1	5.80e-04	1284	92	11	17353931
Pubmed	UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.	CUL1 UBXN8 HUWE1	6.05e-04	62	92	3	18775313
Pubmed	Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1.	ACAN VCAN	6.17e-04	14	92	2	30459452
Pubmed	SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.	RELN DCTN1	6.17e-04	14	92	2	19874786
Pubmed	The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1.	PIK3C3 SACM1L	6.17e-04	14	92	2	31806350
Pubmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.	CUL1 CS SF3B3 PIGG HUWE1 MFSD12	6.23e-04	392	92	6	33144569
Pubmed	Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.	PSMD6 SF3B3 NOP56 DOCK7 DCTN1	6.39e-04	259	92	5	31162944
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	NOP56 DOCK7 SPAG9 HUWE1 SPEN DCTN1 CREBBP	6.48e-04	549	92	7	38280479
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KCNH2 ABCD1 PIGG HUWE1 NCLN SPEN DCTN1 MFSD5 MFSD12 SDHA	6.88e-04	1105	92	10	35748872
Pubmed	Genetic dissection of plexin signaling in vivo.	RELN ACAN	7.11e-04	15	92	2	24469813
Pubmed	FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator).	CUL1 SF3B3	7.11e-04	15	92	2	27365398
Pubmed	SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism.	CS CREBBP	7.11e-04	15	92	2	31108370
Pubmed	Muscleblind-like 1 is required for normal heart valve development in vivo.	ACAN VCAN	7.11e-04	15	92	2	26472242
Pubmed	Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation.	ACAN VCAN	7.11e-04	15	92	2	38018454
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	CUL1 KCNH2 CPD TNFAIP1 HACD2 CREBBP KCNH4 SACM1L	7.17e-04	730	92	8	34857952
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	PSMD6 CS SF3B3 PTPRQ DOCK7 SPAG9 HACD2 NCLN DCTN1 CREBBP RUSF1	7.33e-04	1321	92	11	27173435
Pubmed	Consequences of COP9 signalosome and 26S proteasome interaction.	PSMD6 CUL1	8.11e-04	16	92	2	16045761
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	PSMD6 CUL1 A2ML1 HUWE1 NCLN DCTN1 SDHA	8.15e-04	571	92	7	37167062
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	PSMD6 PPP2R3A CS SF3B3 NOP56 PPEF1 SDHA	8.32e-04	573	92	7	28330616
Interaction	VIPR1 interactions	FDFT1 CDS2 KDELR1 PIGG HACD2 MFSD5 RUSF1 SACM1L	3.49e-06	205	89	8	int:VIPR1
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	ACAN VCAN	6.91e-05	4	62	2	574
Coexpression	GSE26669_CTRL_VS_COSTIM_BLOCK_MLR_CD8_TCELL_DN	KIAA1217 CDS2 PIP4K2A GPR87 TNFAIP1 CREBBP FAM43A	6.87e-06	200	92	7	M4667
ToppCell	CF\|World / Disease state, Lineage and Cell class	MGAM FCAR ZNF267 CPD SPAG9 SLC45A4	2.52e-06	187	92	6	eec4d4e4a658e3a61c05745167a1a5e3d39bb43e
ToppCell	LPS_only-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLI1 ACER3 KIAA1217 SNRK TNFAIP1 SHANK3	3.12e-06	194	92	6	58f069efdefa0366033764446b9d6ffd4a17807e
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLI1 ACER3 KIAA1217 SNRK TNFAIP1 SHANK3	3.12e-06	194	92	6	bfd92ec75facb0ba55c31e5f2e089d983b3d0169
ToppCell	background-Endothelial_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	FLI1 RELN SRGAP1 PIP4K2A SHANK3 FAM43A	3.21e-06	195	92	6	c7d60dabfc7cb310e002cab10003dadfcc34fe33
ToppCell	E16.5-samps-Endothelial-Immature_fetal_endothelial-Matrix_Endothelial\|E16.5-samps / Age Group, Lineage, Cell class and subclass	FLI1 SNRK SHANK3 AK7 FAM43A	1.70e-05	154	92	5	928f49839b046b90c2f942458f3e365ddc4e0bc9
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NDST3 FLI1 LONRF3 MORC2 SHANK3	1.81e-05	156	92	5	1928c86deb3bcd01db4ae76919a351066aadb39a
Disease	Involutional paraphrenia	RELN GALR2 CRHR1	5.81e-05	25	89	3	C1571983
Disease	Psychosis, Involutional	RELN GALR2 CRHR1	5.81e-05	25	89	3	C1571984
Disease	Involutional Depression	RELN GALR2 CRHR1	5.81e-05	25	89	3	C0011574
Disease	Lymphoma, Non-Hodgkin	PRF1 SPEN CREBBP	1.23e-04	32	89	3	C0024305
Disease	syndromic X-linked intellectual disability (implicated_via_orthology)	HUWE1 CASK	2.49e-04	8	89	2	DOID:0060309 (implicated_via_orthology)
Disease	leukodystrophy (implicated_via_orthology)	ACER3 SDHA	3.19e-04	9	89	2	DOID:10579 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	NDST3 CREBBP SHANK3 CASK	1.18e-03	152	89	4	DOID:0060041 (implicated_via_orthology)
Disease	Nonorganic psychosis	KCNH2 APOBEC3C CRHR1	1.20e-03	69	89	3	C0349204
Disease	response to alcohol	OR2T8 PIGG CNGB1	1.53e-03	75	89	3	EFO_0005526

Protein segments in the cluster

Peptide	Gene	Start	Entry
LGSYLHILFSLYTRT	ACER3	226	Q9NUN7
VFHYRAATSRYTLNF	VCAN	151	P13611
LVYSLSLLQATLHRY	DCTN1	656	Q14203
LRQIHRSFFSAYLGY	BCL2L10	56	Q9HD36
GSLYYTTVRALTRHD	TNFAIP1	36	Q13829
FVFQRYRLEHYTVTS	ALG9	396	Q9H6U8
HSNVNLTIFTARLYY	APOBEC3C	111	Q9NRW3
QNAYLHLRPFYSTTR	A2ML1	436	A8K2U0
ILSKYHRFISFTLYL	CDS2	161	O95674
TRRVYISYLDSIHFF	CREBBP	1426	Q92793
HTYRELYSRSLRLSQ	ACSF3	66	Q4G176
SSVVALYRSHLLYAI	ANKRD24	1106	Q8TF21
RTFLSSYYRDHNVEL	NDST3	836	O95803
LARLFSRLYTYKRTH	NCLN	251	Q969V3
VSYAFILYSILHIRS	OR8D1	216	Q8WZ84
IRLDSTLRLYHAHTY	SPAG9	1106	O60271
SFRSRLVAHAYRLYF	ABCD1	161	P33897
HFLVSRFYSRTNSFL	OVOS1	396	Q6IE37
ILQRTYAHYFDLTII	CASK	881	O14936
VVSLSEYRQSLHTYL	NOP56	271	O00567
YSRHVTTRAALTYTS	M1AP	126	Q8TC57
LNSSRHYLNIRYTLL	MGAM	706	O43451
FNNTSTYVIYAHLLR	HECTD2	241	Q5U5R9
AIIQRLYSGTARYHT	KCNH2	661	Q12809
LISRSHYSPIYLSFV	FDFT1	376	P37268
SVYSRFYFDLRTLAH	CCNYL2	291	Q5T2Q4
HYRFRYSDTLELVVT	FCAR	106	P24071
YTSYFILLGLFNHTR	OR2T8	6	A6NH00
AYLRLISNYGTHFIR	PRF1	211	P14222
SRRSAYIAALYFTLS	KCNH4	421	Q9UQ05
TAFDIARRTSIYHYL	ANKRD49	211	Q8WVL7
HYFLELRRLSPSLYS	PGAP4	311	Q9BRR3
TFSSIYALIQHYRET	PLCG2	606	P16885
LYHQVYLTTDSRRSD	PCDHGC3	756	Q9UN70
ALLIEYSFSRHLYSS	HUWE1	101	Q7Z6Z7
IHSARYIFVENLYRS	TK2	136	O00142
FHSRYITTVIQRIFY	PPP2R3A	841	Q06190
FHVTRTLYYSFRSLD	P2RY2	261	P41231
YIAISRYIHKSSRQF	GPR87	226	Q9BY21
HYRAISTRYTLDFDR	ACAN	156	P16112
GSSRLSSYHNFYSIR	RELN	716	P78509
YSSLNRAQLTFEYLH	MORC2	6	Q9Y6X9
LRPHTLYNISVRSYT	PTPRQ	766	Q9UMZ3
YALRILSHLVSYANS	GALR2	271	O43603
RNSLLASYIHYVFRL	DOCK7	841	Q96N67
HNSTLLRYSVSLLGY	CERK	276	Q8TCT0
RSYQRFTAFYASRHS	CUL1	561	Q13616
YTDHQFTELTRLYLT	CS	246	O75390
IIRYSFYTFSLLNHL	HACD2	146	Q6Y1H2
LYNTEVLLSHLSYLR	FLI1	181	Q01543
RSSSNLALALYRYHS	CPD	921	O75976
TLILIVSSYAFRYHN	CERS1	186	P27544
YLHTAIVLTYSTDRL	CRHR1	241	P34998
YAVSLHYSALSSLAR	FAM43A	26	Q8N2R8
TITSHYLFALGVYRT	KDELR1	146	P24390
FYFSTTYDLTHTLQR	SACM1L	131	Q9NTJ5
TYLLLYLHSVRAYSS	MFSD12	41	Q6NUT3
SSLYRIATSKRYHLQ	MFSD5	296	Q6N075
TRNVFSHRLSVYRKY	PIP4K2A	196	P48426
IHAYSQLLESYRSLT	PSMD6	301	Q15008
AHSTLVETLYRYRSD	PPEF1	556	O14829
LYRHSYDLSSAISVL	MTA3	241	Q9BTC8
ARHAATSRTYLYRLA	PUSL1	121	Q8N0Z8
FLTALHIYANYRAVR	RUSF1	266	Q96GQ5
VTASSRIHIYGRYSQ	UTP15	56	Q8TED0
LGYHASLNRALRTYL	SRGAP1	271	Q7Z6B7
TTRLFLYYHTLANTR	SAMD8	356	Q96LT4
LHTLYGRSLRYDTSY	SDHA	201	P31040
LLSSHYTNPTVRRYA	PIK3C3	366	Q8NEB9
ISYQSSSTEERRLHY	SEMG1	286	P04279
ISYQSSSTEERRLHY	SEMG1	346	P04279
IIAYHRTAIRSASAY	KIAA1217	421	Q5T5P2
RYNHITATYFLLAER	SNRK	321	Q9NRH2
TLHALSRYSRYTSIL	SMCR8	796	Q8TEV9
VIRTTAYLLYSLHLN	CNGB1	791	Q14028
FSQTSYLVYHRRLHT	ZNF845	336	Q96IR2
RHAFRRQASSTFSYY	SLC45A4	416	Q5BKX6
AFRYSTYLNVHTRTH	ZNF846	486	Q147U1
YSTQRGVYLLTSHRT	RBP3	531	P10745
RTLQHGLYYASRSRS	SPEN	176	Q96T58
RLFRHYTVGSYDSLT	SHANK3	546	Q9BYB0
LHTQYLESFLRSQFY	SESN3	81	P58005
KFFSRVSYLTIHYRS	RBAK	436	Q9NYW8
FNYRSYLTTHQRSHT	ZNF267	641	Q14586
AARIAYSSYIFSLVR	SLC19A1	131	P41440
RYLQLTQSELSSYHR	TTC9C	146	Q8N5M4
LSYSYQSRFHLTPLS	SF3B3	721	Q15393
TDTFTAYYRLLITHL	TPGS2	186	Q68CL5
FSRLSYLTVHYRTHS	ZNF12	446	P17014
VFTYIVLVTSLRYHL	PIGG	931	Q5H8A4
YHISLYSLSTSFPRR	UBXN8	226	O00124
LRSYTQSGDLYRHIR	ZBTB3	506	Q9H5J0
THYSQDRFLRALSNY	AK7	546	Q96M32
DHLLYSNRSQIYFTL	LONRF3	276	Q496Y0