Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domain-

MANBA HECTD1 PCSK4 F5

6.30e-05735542.60.120.260
Pubmed

Tight junction protein occludin is an internalization factor for SARS-CoV-2 infection and mediates virus cell-to-cell transmission.

ACE2 OCLN

2.93e-06260237068248
Pubmed

Testis-enriched ferlin, FER1L5, is required for Ca2+-activated acrosome reaction and male fertility.

FER1L4 FER1L5

8.77e-06360236696506
Pubmed

A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls.

DIP2C F5

1.75e-05460223703922
Pubmed

Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction.

KCNB1 C1RL LY75 ADH1B

3.36e-0510560424667918
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

STK11 LIMK1 FBXO25 FBXO9 ROR2 TCF25

4.42e-0537260622939624
Pubmed

Frizzled3 and Frizzled6 Cooperate with Vangl2 to Direct Cochlear Innervation by Type II Spiral Ganglion Neurons.

CELSR1 ROR2

1.05e-04960231462532
Pubmed

Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.

CELSR1 ROR2 TCF25 DIP2C

1.09e-0414260419851296
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

CELSR1 SLC25A39 MAEA KAT6A DIP2C APEH ESPL1 HECTD1 GGA3

1.10e-04110560935748872
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

DOCK11 YLPM1 ZBTB10 RFC3 ESPL1 HECTD1

1.11e-0444060634244565
Pubmed

Association of genetic variants with hemorrhagic stroke in Japanese individuals.

CELSR1 ROR2 TCF25 DIP2C

1.12e-0414360420198315
Pubmed

Genome-wide association study of Alzheimer's disease with psychotic symptoms.

STK11 DIP2C

1.59e-041160222005930
Pubmed

The Vertebrate Genome Annotation browser 10 years on.

SMIM27 KCNB1 SLC6A16 TTLL8

1.85e-0416360424316575
Pubmed

Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.

SLC25A41 SLC25A39

2.26e-041360216949250
Pubmed

Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure.

LIMK1 CELSR1

2.26e-041360217229766
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

MPP2 FARSA KCNB1 IQGAP2 DOCK11 SYNE1 TBC1D7 YLPM1

2.40e-0496360828671696
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

FARSA IQGAP2 KAT6A TCF25 RFC3 ESPL1 HECTD1

3.25e-0475960735915203
Pubmed

The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors.

MPP2 FARSA IQGAP2 ZBTB10 RFC3

3.48e-0435060526549023
Pubmed

A method to identify cDNAs based on localization of green fluorescent protein fusion products.

KAT6A YLPM1

3.91e-041760210716735
Pubmed

Wnt ligand/Frizzled 2 receptor signaling regulates tube shape and branch-point formation in the lung through control of epithelial cell shape.

CELSR1 TCF7L1

6.02e-042160225114215
Pubmed

Primary cilia in murine palatal rugae development.

CELSR1 ROR2

7.23e-042360231226309
Pubmed

Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.

FARSA MAEA RFC3

8.07e-0410560322505724
Pubmed

Network organization of the human autophagy system.

STK11 IQGAP2 TBC1D7 YLPM1 NIPSNAP1

9.48e-0443760520562859
Pubmed

Loss of LKB1 leads to impaired epithelial integrity and cell extrusion in the early mouse embryo.

STK11 OCLN

1.07e-032860225588837
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

ROR2 FAM171B OCLN GGA3

1.12e-0326360434702444
Pubmed

LINKIN, a new transmembrane protein necessary for cell adhesion.

FARSA NIPSNAP1 APEH OCLN RFC3

1.44e-0348060525437307
Pubmed

Analysis of mouse embryonic patterning and morphogenesis by forward genetics.

ROR2 HECTD1

1.49e-033360215755804
Pubmed

BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.

ROR2 TBC1D7 OCLN GGA3

1.50e-0328560434369648
Pubmed

LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.

STK11 KCNB1

1.58e-033460226378152
Pubmed

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.

ATR RFC3

1.58e-033460212791985
Pubmed

Global identification of modular cullin-RING ligase substrates.

FARSA MAEA RFC3

1.63e-0313460321963094
InteractionCTSG interactions

CELSR1 MANBA MAEA TCF25 F5

5.51e-0695545int:CTSG
InteractionNF2 interactions

MPP2 ACE2 STK11 FARSA ZBTB10 OCLN RFC3 HECTD1

7.67e-06383548int:NF2
CytobandEnsembl 112 genes in cytogenetic band chr19p13

STK11 SLC25A41 FARSA OLFM2 ZNF442 PCSK4

6.06e-04797606chr19p13
Cytoband14q12

ADCY4 HECTD1

2.39e-035560214q12
Cytoband19p13.2

FARSA OLFM2 ZNF442

3.40e-0322960319p13.2
Cytoband19p13.3

STK11 SLC25A41 PCSK4

3.74e-0323760319p13.3
GeneFamilyFerlin family

FER1L4 FER1L5

6.76e-056392828
GeneFamilyCyclins|F-boxes other

FBXO25 FBXO9

3.19e-0339392560
GeneFamilySolute carriers

SLC43A2 SLC25A41 SLC6A16 SLC25A39

1.01e-02395394752
ToppCellP15-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LIMK1 CELSR1 DPY19L3 IQGAP2 C1RL

3.97e-06176605792f414f5092aba14260b8e16378e793a822498e
Diseaselimb-girdle muscular dystrophy (implicated_via_orthology)

FER1L4 FER1L5

7.92e-057582DOID:11724 (implicated_via_orthology)
Diseaseendometrial cancer (implicated_via_orthology)

STK11 ATR

1.06e-048582DOID:1380 (implicated_via_orthology)
DiseasePosterior Choroidal Artery Infarction

F5 ADH1B

2.06e-0411582C0887799
DiseaseCerebral Infarction, Left Hemisphere

F5 ADH1B

2.06e-0411582C0751010
DiseaseAnterior Choroidal Artery Infarction

F5 ADH1B

2.06e-0411582C0751012
DiseaseCerebral Infarction, Right Hemisphere

F5 ADH1B

2.06e-0411582C0751011
DiseaseSubcortical Infarction

F5 ADH1B

2.06e-0411582C0751014
DiseaseCerebral Infarction

F5 ADH1B

2.06e-0411582C0007785
DiseaseColorectal Carcinoma

STK11 SYNE1 DIP2C OLFM2 ZNF442 F5 ADH1B

4.39e-04702587C0009402
DiseaseStomach Carcinoma

STK11 ATR

7.78e-0421582C0699791
Diseasemean platelet volume

SLC43A2 IQGAP2 DOCK11 DIS3L ZBTB10 LY75 ESPL1 OPRD1

8.21e-041020588EFO_0004584
Diseaseblood pressure

SYNE1 TBC1D7

8.55e-0422582EFO_0004325
DiseaseNeoplasm of uncertain or unknown behavior of ovary

STK11 ATR

1.49e-0329582C0496920
DiseaseOvarian Carcinoma

STK11 ATR

1.59e-0330582C0029925
Diseasepulmonary hypertension (is_implicated_in)

ACE2 F5

1.59e-0330582DOID:6432 (is_implicated_in)
Diseaseplasma betaine measurement

DPY19L3 LY75

2.05e-0334582EFO_0007787
DiseaseMalignant Neoplasms

STK11 ATR OCLN

2.07e-03128583C0006826
DiseaseParkinson's disease (implicated_via_orthology)

FBXO9 NIPSNAP1 OPRD1

3.68e-03157583DOID:14330 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
PMLLLTGRTWKGAVY

ADH1B

306

P00325
LSYSLKKRMPTEGPW

FAM220BP

26

B1ANY3
LLMTRYLESWGAAKP

ADCY4

476

Q8NFM4
VPWYLGLMFRTRKED

CELSR1

1711

Q9NYQ6
DSLDMLPAVKATWLY

DPY19L3

276

Q6ZPD9
EVMRSWDTGYPKRSA

OLFM2

356

O95897
YKWTSPPGVIRILSM

OCLN

56

Q16625
ISPYKDLLDPARWRM

MAEA

251

Q7L5Y9
LTAPVIGYIMDWRLK

SLC43A2

376

Q8N370
PLTGEMSSDIYVKSW

FER1L4

1511

A9Z1Z3
GMSMDLPLYAWLSRA

PCSK4

726

Q6UW60
YMSAKTWLIDLGKPT

LY75

906

O60449
ELLYSWTMALPEEAK

GGA3

116

Q9NZ52
TPTLYMLSEDRQLWK

FBXO25

256

Q8TCJ0
TYTVWDLLLGMDRPD

NALF2

201

O75949
KNKLIMWDPDRYGTT

MPP2

391

Q14168
PTMGNTDFWKTLRYL

PARP4

946

Q9UKK3
SAKYLMETWPFGELL

OPRD1

106

P41143
TPRKSLSMYTWLEIQ

FADS2B

51

A8MWK0
KPLSDLGRLSYMAYW

KAT6A

681

Q92794
SMPRMLTLWLDYGTK

ATR

2086

Q13535
SDKLRRIWEPTYTIM

HECTD1

1861

Q9ULT8
WKYPDRTLLKIMLSG

ESPL1

1831

Q14674
TMEYLLRFLSSPKKW

KCNB1

241

Q14721
YASTPELRKTWLDSM

DOCK11

1611

Q5JSL3
IKLVPYTSWREMFLE

FBXO9

246

Q9UK97
YLPRERGESMEKWQT

DIS3L

126

Q8TF46
DPSLTLKDRMWYLQS

POLQ

1936

O75417
LSYSPWESSRRKMGT

COL6A5

2011

A8TX70
EMGWLTTELKYSRLP

C1RL

381

Q9NZP8
PLYILTYGKLWTRSM

DIP2C

346

Q9Y2E4
IVGTLPFTYMLEKWR

ACE2

446

Q9BYF1
GDPVRWEYMLLGTDK

DRC7

366

Q8IY82
MTEKTRTILFYPWEP

MANBA

846

O00462
WKTRRMPIYSSVTLS

FAM171B

151

Q6P995
MSLWVDKYRPCSLGR

RFC3

1

P40938
ELRTYKLKPGTMIEW

NIPSNAP1

186

Q9BPW8
TWGIMALSRYPIVKS

CWH43

501

Q9H720
MSWDSSTSKEVLRPY

SLC6A16

641

Q9GZN6
KWMLPEKSRGTYLER

RHBDL2

51

Q9NX52
AWGLSLERPTMIKYG

FARSA

456

Q9Y285
RKWLVEVSYLPMSGL

SYNE1

7576

Q8NF91
GVEWKPYRLKSSMVD

F5

2161

P12259
PKDMVATAEDWLYRL

FER1L5

671

A0AVI2
WLRAMESIGLPKIFY

IQGAP2

116

Q13576
MKPVSRRTLDWIYSV

SMIM27

1

A0A1B0GUW7
WLGLYRGMTPTLLKV

SLC25A41

336

Q8N5S1
PDTKDRWRSMTVVPY

STK11

326

Q15831
YKLLGNSLLPIRWMA

ROR2

646

Q01974
LPSMYRALVWKVLLG

TBC1D7

51

Q9P0N9
SVWAEMLDKSPIRYI

APEH

646

P13798
EMPYLLWTIKRDIID

TTLL8

131

A6PVC2
MPSSRLWSLSYTKLP

SLC25A39

51

Q9BZJ4
RTYLQMKWPLLDVPS

TCF7L1

146

Q9HCS4
EIYRWPARESLKTML

RYR3

2666

Q15413
ELGYIPKSKWEMDTS

YLPM1

2036

P49750
LGPSQKSLYRDVMWE

ZNF442

46

Q9H7R0
KDFPWLRYSKDTGLM

ZBTB10

256

Q96DT7
WPRYSKPGLSMRLLE

TCF25

226

Q9BQ70
LRGIIKSMDSQYPWS

LIMK1

421

P53667