Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	dynein light intermediate chain binding	CCDC88A HOOK1 RILPL1	1.75e-04	28	78	3	GO:0051959
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	NR1I2 KLF10 MZF1 PITX2 PITX3 GBX2 FIGLA PAX6 SMAD1	3.29e-04	560	78	9	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	NR1I2 KLF10 MZF1 PITX2 PITX3 GBX2 FIGLA PAX6 SMAD1	3.55e-04	566	78	9	GO:0001216
GeneOntologyMolecularFunction	DEAD/H-box RNA helicase binding	SMAD1 SMAD5	5.33e-04	9	78	2	GO:0017151
GeneOntologyBiologicalProcess	maintenance of location in cell	CCDC88A PSEN1 SYNE1 ANXA6 SUPT7L ASPM TMED2	6.09e-05	259	79	7	GO:0051651
GeneOntologyBiologicalProcess	maintenance of protein location	CCDC22 CCDC88A SYNE1 SUPT7L TMED2	7.06e-05	112	79	5	GO:0045185
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization	CCDC69 CCDC88A HOOK1 TTLL5 RP1L1 ASPM SENP6 CEP295 RSPH6A PAX6 HYDIN	9.05e-05	720	79	11	GO:0000226
GeneOntologyBiologicalProcess	organelle assembly	CCDC69 FLII CCDC88A PSEN1 SYNE1 TTLL5 RP1L1 ASPM SENP6 CEP295 RSPH6A PATL1 RILPL1 HYDIN	9.61e-05	1138	79	14	GO:0070925
GeneOntologyBiologicalProcess	forebrain generation of neurons	PLXNA3 ASPM GBX2 PAX6	1.13e-04	65	79	4	GO:0021872
GeneOntologyBiologicalProcess	maintenance of location	CCDC22 CCDC88A PSEN1 SYNE1 ANXA6 SUPT7L ASPM TMED2	1.37e-04	396	79	8	GO:0051235
GeneOntologyBiologicalProcess	regulation of asymmetric cell division	ASPM PAX6	1.44e-04	5	79	2	GO:0009786
GeneOntologyBiologicalProcess	retina development in camera-type eye	PSEN1 TTLL5 RP1L1 LAMC3 PAX6 NPHP4	1.59e-04	211	79	6	GO:0060041
GeneOntologyBiologicalProcess	neuron migration	PLXNA3 PSEN1 PITX2 ASPM APBB1 PAX6	1.90e-04	218	79	6	GO:0001764
GeneOntologyBiologicalProcess	maintenance of protein location in cell	CCDC88A SYNE1 SUPT7L TMED2	2.07e-04	76	79	4	GO:0032507
GeneOntologyBiologicalProcess	regulation of core promoter binding	PSEN1 PAX6	2.15e-04	6	79	2	GO:1904796
GeneOntologyBiologicalProcess	osteoblast fate commitment	SMAD1 SMAD5	2.15e-04	6	79	2	GO:0002051
GeneOntologyBiologicalProcess	camera-type eye development	PSEN1 TTLL5 RP1L1 PITX2 PITX3 LAMC3 PAX6 NPHP4	2.25e-04	426	79	8	GO:0043010
GeneOntologyCellularComponent	centrosome	FLII CCDC22 CCDC88A PSEN1 HOOK1 TTLL5 BUB1B ASPM CEP295 RILPL1 NPHP4	1.45e-04	770	79	11	GO:0005813
GeneOntologyCellularComponent	heteromeric SMAD protein complex	SMAD1 SMAD5	3.89e-04	8	79	2	GO:0071144
GeneOntologyCellularComponent	nuclear body	SRRT ZNF106 NR1I2 SIMC1 TENM1 APBB1 ZNF638 PRPF19 PATL1 NPHP4 NSMCE4A	5.66e-04	903	79	11	GO:0016604
GeneOntologyCellularComponent	SMAD protein complex	SMAD1 SMAD5	6.22e-04	10	79	2	GO:0071141
GeneOntologyCellularComponent	microtubule organizing center	FLII CCDC22 CCDC88A PSEN1 HOOK1 TTLL5 BUB1B ASPM CEP295 RILPL1 NPHP4	6.55e-04	919	79	11	GO:0005815
GeneOntologyCellularComponent	lysosome	SPACA7 NEU2 SLC11A2 PSEN1 ANXA6 TLR3 TSC1 IDUA TASL CTSG	9.36e-04	811	79	10	GO:0005764
GeneOntologyCellularComponent	lytic vacuole	SPACA7 NEU2 SLC11A2 PSEN1 ANXA6 TLR3 TSC1 IDUA TASL CTSG	9.36e-04	811	79	10	GO:0000323
Domain	ASH	ASPM HYDIN	1.59e-05	2	75	2	IPR031549
Domain	ASH	ASPM HYDIN	1.59e-05	2	75	2	PF15780
Domain	Homeobox_Pitx/unc30	PITX2 PITX3	4.76e-05	3	75	2	IPR016233
Domain	HOOK	CCDC88A HOOK1	2.36e-04	6	75	2	PF05622
Domain	Hook-related_fam	CCDC88A HOOK1	2.36e-04	6	75	2	IPR008636
Domain	Dwarfin	SMAD1 SMAD5	4.39e-04	8	75	2	IPR013790
Domain	DWB	SMAD1 SMAD5	4.39e-04	8	75	2	SM00524
Domain	MH2	SMAD1 SMAD5	4.39e-04	8	75	2	PS51076
Domain	MH1	SMAD1 SMAD5	4.39e-04	8	75	2	PS51075
Domain	-	SMAD1 SMAD5	4.39e-04	8	75	2	3.90.520.10
Domain	MAD_homology_MH1	SMAD1 SMAD5	4.39e-04	8	75	2	IPR013019
Domain	MH2	SMAD1 SMAD5	4.39e-04	8	75	2	PF03166
Domain	-	TMEM131 HYDIN	4.39e-04	8	75	2	2.60.40.360
Domain	SMAD_dom_Dwarfin-type	SMAD1 SMAD5	4.39e-04	8	75	2	IPR001132
Domain	PapD-like	TMEM131 HYDIN	5.62e-04	9	75	2	IPR008962
Domain	MAD_homology1_Dwarfin-type	SMAD1 SMAD5	1.02e-03	12	75	2	IPR003619
Domain	DWA	SMAD1 SMAD5	1.02e-03	12	75	2	SM00523
Domain	MH1	SMAD1 SMAD5	1.02e-03	12	75	2	PF03165
Domain	OAR	PITX2 PITX3	1.62e-03	15	75	2	PF03826
Domain	OAR	PITX2 PITX3	1.84e-03	16	75	2	PS50803
Domain	SMAD_dom-like	SMAD1 SMAD5	1.84e-03	16	75	2	IPR017855
Domain	-	SMAD1 SMAD5	1.84e-03	16	75	2	2.60.200.10
Domain	OAR_dom	PITX2 PITX3	1.84e-03	16	75	2	IPR003654
Domain	Myosin-like_IQ_dom	MYH7B ASPM	2.60e-03	19	75	2	IPR027401
Domain	-	MYH7B ASPM	2.60e-03	19	75	2	4.10.270.10
Domain	Spectrin_repeat	SYNE1 KRT77	6.02e-03	29	75	2	IPR002017
Domain	Homeobox_CS	PITX2 PITX3 GBX2 PAX6	6.68e-03	186	75	4	IPR017970
Domain	Spectrin/alpha-actinin	SYNE1 KRT77	7.30e-03	32	75	2	IPR018159
Domain	SPEC	SYNE1 KRT77	7.30e-03	32	75	2	SM00150
Pathway	WP_BMP_SIGNALING_PATHWAY_IN_EYELID_DEVELOPMENT	PITX2 SMAD1 SMAD5	6.80e-05	20	57	3	MM15907
Pathway	WP_BMP_SIGNALING_IN_EYELID_DEVELOPMENT	PITX2 SMAD1 SMAD5	6.80e-05	20	57	3	M39624
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	CCDC22 CCDC88A HOOK1 TTLL5 ANXA6 SIMC1 BUB1B TSC1 TMEM131 CEP295 PATL1 EMSY NUP205	6.30e-08	853	79	13	28718761
Pubmed	The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter.	PAX6 SMAD1 SMAD5	1.12e-07	5	79	3	17251190
Pubmed	Human transcription factor protein interaction networks.	SRRT KLF10 ATXN7L1 RPS3A DDX52 SUPT7L ZNF638 PRPF19 TMED2 PATL1 PAX6 JMJD1C EMSY SMAD5 HMG20A NUP205	1.14e-07	1429	79	16	35140242
Pubmed	Lack of the bone morphogenetic protein BMP6 induces massive iron overload.	SLC11A2 SMAD1 SMAD5	2.24e-07	6	79	3	19252488
Pubmed	Deletion of Lrp4 increases the incidence of microphthalmia.	PITX2 PITX3 PAX6 SMAD1 SMAD5	5.33e-07	69	79	5	30352686
Pubmed	Sma- and Mad-related protein 7 (Smad7) is required for embryonic eye development in the mouse.	PITX2 PAX6 SMAD1 SMAD5	6.46e-07	30	79	4	23426374
Pubmed	SMAD 8 binding to mice Msx1 basal promoter is required for transcriptional activation.	KLF10 SMAD1 SMAD5	1.34e-06	10	79	3	16101586
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	SRRT RPS3A SIMC1 ANKRD11 ZNF638 SENP6 PRPF19 ZDBF2 JMJD1C EMSY HMG20A NSMCE4A	1.60e-06	954	79	12	36373674
Pubmed	Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.	SRRT FLII RPS3A DDX52 ZNF638 TMEM131 NPHP4 EMSY	1.71e-06	361	79	8	30344098
Pubmed	mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia.	TSC1 PAX6 SMAD1 SMAD5	2.12e-06	40	79	4	34677125
Pubmed	BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment.	PITX2 SMAD1 SMAD5	3.17e-06	13	79	3	18550712
Pubmed	Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis.	PAX6 SMAD1 SMAD5	3.17e-06	13	79	3	15893304
Pubmed	Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain.	PITX3 GBX2 PAX6 FGF17	3.42e-06	45	79	4	17687036
Pubmed	The chromatin regulator Ankrd11 controls cardiac neural crest cell-mediated outflow tract remodeling and heart function.	ANKRD11 SMAD1 SMAD5	4.03e-06	14	79	3	38951500
Pubmed	Ocular coloboma and dorsoventral neuroretinal patterning defects in Lrp6 mutant eyes.	PAX6 SMAD1 SMAD5	4.03e-06	14	79	3	18985738
Pubmed	Cytoneme signaling provides essential contributions to mammalian tissue patterning.	PAX6 SMAD1 SMAD5	4.03e-06	14	79	3	38171360
Pubmed	Mutation in Bmpr1b Leads to Optic Disc Coloboma and Ventral Retinal Gliosis in Mice.	PAX6 SMAD1 SMAD5	4.03e-06	14	79	3	32106289
Pubmed	Roles of Bmp4 during tooth morphogenesis and sequential tooth formation.	PITX2 SMAD1 SMAD5	4.03e-06	14	79	3	23250216
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PLXNA3 HOOK1 NHSL2 MYH7B DDX52 SYNE1 KRT77 ASPM TENM1 PRPF19 TSC1 CEP295 NSMCE4A NUP205	4.15e-06	1442	79	14	35575683
Pubmed	ALK5-mediated transforming growth factor β signaling in neural crest cells controls craniofacial muscle development via tissue-tissue interactions.	PITX2 SMAD1 SMAD5	5.03e-06	15	79	3	24912677
Pubmed	BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells.	SMAD1 SMAD5	5.09e-06	2	79	2	26711875
Pubmed	The transcriptional role of Smads and FAST (FoxH1) in TGFbeta and activin signalling.	SMAD1 SMAD5	5.09e-06	2	79	2	11451566
Pubmed	PITX3 promoter methylation is a prognostic biomarker for biochemical recurrence-free survival in prostate cancer patients after radical prostatectomy.	PITX2 PITX3	5.09e-06	2	79	2	27708722
Pubmed	BMP-SMAD1/5 Signaling Regulates Retinal Vascular Development.	SMAD1 SMAD5	5.09e-06	2	79	2	32210087
Pubmed	BMP receptor-integrin interaction mediates responses of vascular endothelial Smad1/5 and proliferation to disturbed flow.	SMAD1 SMAD5	5.09e-06	2	79	2	23387849
Pubmed	Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.	SMAD1 SMAD5	5.09e-06	2	79	2	8799132
Pubmed	BMP signaling dynamics in embryonic orofacial tissue.	SMAD1 SMAD5	5.09e-06	2	79	2	18446813
Pubmed	Effect of localization, length and orientation of chondrocytic primary cilium on murine growth plate organization.	SMAD1 SMAD5	5.09e-06	2	79	2	21723296
Pubmed	Regulation of the levels of Smad1 and Smad5 in MC3T3-E1 cells by Icariine in vitro.	SMAD1 SMAD5	5.09e-06	2	79	2	24297369
Pubmed	Meis1 Coordinates Cerebellar Granule Cell Development by Regulating Pax6 Transcription, BMP Signaling and Atoh1 Degradation.	PAX6 SMAD1 SMAD5	6.18e-06	16	79	3	29317485
Pubmed	The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation.	PAX6 SMAD1 SMAD5	6.18e-06	16	79	3	19733164
Pubmed	Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain.	PAX6 SMAD1 SMAD5	6.18e-06	16	79	3	20730911
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ZNF106 CCDC22 CCDC88A ZNF638 TSC1 TMEM131 CEP295 ZDBF2 PATL1 JMJD1C	6.33e-06	733	79	10	34672954
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SRRT ZNF106 RPS3A DDX52 SUPT7L PHRF1 ANKRD11 ZNF638 PRPF19 PAX6 JMJD1C EMSY HMG20A	6.64e-06	1294	79	13	30804502
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	TAOK2 SRRT FLII RPS3A PITX2 PRPF19 ZDBF2 PAX6 NUP205	7.13e-06	583	79	9	29844126
Pubmed	Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium.	PITX2 SMAD1 SMAD5	7.50e-06	17	79	3	18667074
Pubmed	LRP2/megalin is required for patterning of the ventral telencephalon.	PAX6 SMAD1 SMAD5	7.50e-06	17	79	3	15623804
Pubmed	SMAD4 is essential for generating subtypes of neurons during cerebellar development.	PAX6 SMAD1 SMAD5	7.50e-06	17	79	3	22370000
Pubmed	Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD4 and STRA8 Independent of Somatic Sex Reprogramming.	TLR3 SMAD1 SMAD5	7.50e-06	17	79	3	27606421
Pubmed	Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis.	PITX2 SMAD1 SMAD5	7.50e-06	17	79	3	18832393
Pubmed	Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors.	PITX2 PAX6 SMAD1 SMAD5	7.70e-06	55	79	4	28807898
Pubmed	Threshold-specific requirements for Bmp4 in mandibular development.	PITX2 SMAD1 SMAD5	8.98e-06	18	79	3	15936012
Pubmed	Common partner Smad-independent canonical bone morphogenetic protein signaling in the specification process of the anterior rhombic lip during cerebellum development.	PAX6 SMAD1 SMAD5	8.98e-06	18	79	3	23459943
Pubmed	Calcineurin signaling regulates neural induction through antagonizing the BMP pathway.	PAX6 SMAD1 SMAD5	8.98e-06	18	79	3	24698271
Pubmed	Dullard-mediated Smad1/5/8 inhibition controls mouse cardiac neural crest cells condensation and outflow tract septation.	PITX2 SMAD1 SMAD5	8.98e-06	18	79	3	32105214
Pubmed	Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract.	PITX2 SMAD1 SMAD5	8.98e-06	18	79	3	17601530
Pubmed	The indirect role of fibroblast growth factor-8 in defining neurogenic niches of the olfactory/GnRH systems.	PAX6 SMAD1 SMAD5	8.98e-06	18	79	3	24336726
Pubmed	BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4.	PITX2 SMAD1 SMAD5	1.06e-05	19	79	3	18981480
Pubmed	β1-integrin controls cell fate specification in early lens development.	PAX6 SMAD1 SMAD5	1.06e-05	19	79	3	27596755
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	DDX52 SUPT7L SENP6 PRPF19 ZDBF2 JMJD1C EMSY	1.25e-05	339	79	7	30415952
Pubmed	FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate.	PSEN1 SMAD1 SMAD5	1.25e-05	20	79	3	19369394
Pubmed	Persistent Wnt/β-catenin signaling in mouse epithelium induces the ectopic Dspp expression in cheek mesenchyme.	PITX2 SMAD1 SMAD5	1.25e-05	20	79	3	30570432
Pubmed	RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1.	PITX2 SMAD1 SMAD5	1.25e-05	20	79	3	32662771
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	TAOK2 SRRT FAM120C ZNF638 JMJD1C EMSY NUP205	1.30e-05	341	79	7	32971831
Pubmed	Early dorsomedial tissue interactions regulate gyrification of distal neocortex.	PAX6 SMAD1 SMAD5	1.46e-05	21	79	3	31729356
Pubmed	Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects.	PAX6 SMAD1 SMAD5	1.46e-05	21	79	3	23055936
Pubmed	Control of lens development by Lhx2-regulated neuroretinal FGFs.	PAX6 SMAD1 SMAD5	1.46e-05	21	79	3	27633990
Pubmed	Loss of the small GTPase Arl8b results in abnormal development of the roof plate in mouse embryos.	PAX6 SMAD1 SMAD5	1.46e-05	21	79	3	31038803
Pubmed	A novel mouse model of anterior segment dysgenesis (ASD): conditional deletion of Tsc1 disrupts ciliary body and iris development.	PITX2 TSC1 PAX6	1.46e-05	21	79	3	28250050
Pubmed	The bicoid-related Pitx gene family in development.	PITX2 PITX3	1.53e-05	3	79	2	9922405
Pubmed	Non-canonical cyclic AMP SMAD1/5/8 signalling in human granulosa cells.	SMAD1 SMAD5	1.53e-05	3	79	2	30953749
Pubmed	Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation.	SMAD1 SMAD5	1.53e-05	3	79	2	32720893
Pubmed	Direct visualization of Smad1/5/8-mediated transcriptional activity identifies podocytes and collecting ducts as major targets of BMP signalling in healthy and diseased kidneys.	SMAD1 SMAD5	1.53e-05	3	79	2	21381028
Pubmed	Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture.	SMAD1 SMAD5	1.53e-05	3	79	2	20371744
Pubmed	TGF-β1, but not bone morphogenetic proteins, activates Smad1/5 pathway in primary human macrophages and induces expression of proatherogenic genes.	SMAD1 SMAD5	1.53e-05	3	79	2	25505291
Pubmed	Identification and functional modelling of plausibly causative cis-regulatory variants in a highly-selected cohort with X-linked intellectual disability.	TENM1 PAX6	1.53e-05	3	79	2	34388204
Pubmed	Fluoride promotes viability and differentiation of osteoblast-like Saos-2 cells via BMP/Smads signaling pathway.	SMAD1 SMAD5	1.53e-05	3	79	2	23918166
Pubmed	Smad1 and 5 but not Smad8 establish stem cell quiescence which is critical to transform the premature hair follicle during morphogenesis toward the postnatal state.	SMAD1 SMAD5	1.53e-05	3	79	2	24023003
Pubmed	Ablation of Hepatocyte Smad1, Smad5, and Smad8 Causes Severe Tissue Iron Loading and Liver Fibrosis in Mice.	SMAD1 SMAD5	1.53e-05	3	79	2	31127639
Pubmed	TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch.	SMAD1 SMAD5	1.53e-05	3	79	2	19096363
Pubmed	BMP9 promotes cutaneous wound healing by activating Smad1/5 signaling pathways and cytoskeleton remodeling.	SMAD1 SMAD5	1.53e-05	3	79	2	33463047
Pubmed	Erbin plays a critical role in human umbilical vein endothelial cell migration and tubular structure formation via the Smad1/5 pathway.	SMAD1 SMAD5	1.53e-05	3	79	2	30367512
Pubmed	Temporal and mosaic Tsc1 deletion in the developing thalamus disrupts thalamocortical circuitry, neural function, and behavior.	GBX2 TSC1	1.53e-05	3	79	2	23664552
Pubmed	Long-term culture and significant expansion of human Sertoli cells whilst maintaining stable global phenotype and AKT and SMAD1/5 activation.	SMAD1 SMAD5	1.53e-05	3	79	2	25880873
Pubmed	Bone morphogenetic protein 2 stimulation of tumor growth involves the activation of Smad-1/5.	SMAD1 SMAD5	1.53e-05	3	79	2	16247476
Pubmed	Smad and AML proteins synergistically confer transforming growth factor beta1 responsiveness to human germ-line IgA genes.	SMAD1 SMAD5	1.53e-05	3	79	2	10652350
Pubmed	Effective application of bicelles for conformational analysis of G protein-coupled receptors by hydrogen/deuterium exchange mass spectrometry.	NR1I2 OPRM1	1.53e-05	3	79	2	25740347
Pubmed	TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition.	SMAD1 SMAD5	1.53e-05	3	79	2	29376829
Pubmed	BMP signaling initiates a neural crest differentiation program in embryonic rat CNS stem cells.	SMAD1 SMAD5	1.53e-05	3	79	2	15246821
Pubmed	BMP-specific SMADs function as novel repressors of PDGFA and modulate its expression in ovarian granulosa cells and tumors.	SMAD1 SMAD5	1.53e-05	3	79	2	22964636
Pubmed	Variants in PAX6, PITX3 and HSF4 causing autosomal dominant congenital cataracts.	PITX3 PAX6	1.53e-05	3	79	2	34345029
Pubmed	Differential expression of TGF-β superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation.	SMAD1 SMAD5	1.53e-05	3	79	2	27848974
Pubmed	Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.	SMAD1 SMAD5	1.53e-05	3	79	2	20522807
Pubmed	A novel TaulacZ allele reveals a requirement for Pitx2 in formation of the mammillothalamic tract.	PITX2 PAX6	1.53e-05	3	79	2	21898763
Pubmed	Activated NF-κB in bone marrow mesenchymal stem cells from systemic lupus erythematosus patients inhibits osteogenic differentiation through downregulating Smad signaling.	SMAD1 SMAD5	1.53e-05	3	79	2	22897816
Pubmed	Human ovarian cancer cell morphology, motility, and proliferation are differentially influenced by autocrine TGFβ superfamily signalling.	SMAD1 SMAD5	1.53e-05	3	79	2	21945631
Pubmed	Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins.	SMAD1 SMAD5	1.53e-05	3	79	2	14711801
Pubmed	Molecular Interaction Between Smurfl WW2 Domain and PPXY Motifs of Smadl, Smad5, and Smad6-Modeling and Analysis.	SMAD1 SMAD5	1.53e-05	3	79	2	22670624
Pubmed	Soy promotes juvenile granulosa cell tumor development in mice and in the human granulosa cell tumor-derived COV434 cell line.	SMAD1 SMAD5	1.53e-05	3	79	2	25165122
Pubmed	Inactivation of menin, the product of the multiple endocrine neoplasia type 1 gene, inhibits the commitment of multipotential mesenchymal stem cells into the osteoblast lineage.	SMAD1 SMAD5	1.53e-05	3	79	2	12649288
Pubmed	Bmp and Wnt/beta-catenin signals control expression of the transcription factor Olig3 and the specification of spinal cord neurons.	PAX6 SMAD1 SMAD5	1.68e-05	22	79	3	17150208
Pubmed	Central roles of the roof plate in telencephalic development and holoprosencephaly.	PAX6 SMAD1 SMAD5	1.68e-05	22	79	3	16855091
Pubmed	Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy.	GBX2 PAX6 FGF17	1.68e-05	22	79	3	33469032
Pubmed	Msx1 and Msx2 act as essential activators of Atoh1 expression in the murine spinal cord.	PAX6 SMAD1 SMAD5	1.68e-05	22	79	3	24715462
Pubmed	DCC is specifically required for the survival of retinal ganglion and displaced amacrine cells in the developing mouse retina.	PAX6 SMAD1 SMAD5	1.93e-05	23	79	3	20875817
Pubmed	Cell-autonomous repression of Shh by transcription factor Pax6 regulates diencephalic patterning by controlling the central diencephalic organizer.	PITX2 GBX2 PAX6	2.21e-05	24	79	3	25176648
Pubmed	Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones.	KLF10 SMAD1 SMAD5	2.21e-05	24	79	3	24583261
Pubmed	The transcription factor Sox7 modulates endocardiac cushion formation contributed to atrioventricular septal defect through Wnt4/Bmp2 signaling.	PITX2 SMAD1 SMAD5	2.50e-05	25	79	3	33846290
Pubmed	Presenilin 1 in migration and morphogenesis in the central nervous system.	PSEN1 GBX2 PAX6	2.50e-05	25	79	3	15163631
Pubmed	Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals.	PAX6 SMAD1 SMAD5	2.50e-05	25	79	3	36067211
GeneFamily	SMAD family	SMAD1 SMAD5	1.99e-04	8	49	2	750
GeneFamily	PRD class homeoboxes and pseudogenes	PITX2 PITX3 PAX6	1.98e-03	92	49	3	521
Coexpression	GSE22611_MUTANT_NOD2_TRANSDUCED_VS_CTRL_HEK293T_STIMULATED_WITH_MDP_6H_DN	FLII PRPF19 TMED2 NPHP4 NSMCE4A NUP205	3.11e-05	199	79	6	M8148
Coexpression	GSE14350_TREG_VS_TEFF_UP	SYNE1 ANKRD11 ZNF638 TSC1 TMEM131 HMG20A	3.11e-05	199	79	6	M3417
Coexpression	GSE43700_UNTREATED_VS_IL10_TREATED_PBMC_UP	NR1I2 ASPM TENM1 TSC1 FGF17 SMAD5	3.20e-05	200	79	6	M9622
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD8-Tem/emra_CD8\|GI_large-bowel / Manually curated celltypes from each tissue	ARFGEF3 NHSL2 ANXA6 TLR3 PITX2 PAX6	5.13e-07	166	79	6	13bef304ea3df8e8d2bc376a3287c78220a1b0c6
ToppCell	343B-Lymphocytic-ILC\|343B / Donor, Lineage, Cell class and subclass (all cells)	MZF1 APBB1 CEP295 KLRC1 NUP205	1.16e-05	166	79	5	a54377c703efff42d2cc1a8fdb610facc58053dd
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SYNE1 ASPM TENM1 RSPH6A KLRC1	1.20e-05	167	79	5	abc4ba308ca3be41b0da604f5d82579fd58dff7b
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF106 CCDC88A ECM2 ZNF638 JMJD1C	1.54e-05	176	79	5	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TIMD4 BUB1B ASPM TENM1 ZNF638	1.77e-05	181	79	5	3fe648db1cb8326066d8bde3ca1287c5c9af19bd
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TIMD4 BUB1B ASPM TENM1 CEP295	1.81e-05	182	79	5	39f9b3eb22293cc27c6e175702c77d1eeb24fdc9
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF106 CCDC88A ANKRD11 ZNF638 JMJD1C	1.91e-05	184	79	5	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	Mild-Lymphoid-T-NK\|Mild / Condition, Lineage, Cell class and cell subclass	NRIP2 RPS3A SYNE1 ANXA6 KLRC1	2.01e-05	186	79	5	ed37a2df547661d22c1ed0b30cb1c19e489d9d0a
ToppCell	343B-Lymphocytic-ILC\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MZF1 CEP295 PATL1 SMAD5 NUP205	2.17e-05	189	79	5	c26428871dc3261327d89cacaba6e21e004ff1f3
ToppCell	droplet-Lung-30m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l12-14\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARFGEF3 MZF1 BUB1B ASPM NUP205	2.34e-05	192	79	5	52d0aa51e3b6ab3608a5f40bdde9f8134b3afd94
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic-granulocyte\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CCDC88A BUB1B ASPM TASL CTSG	2.72e-05	198	79	5	2e669da80363163b806f23a645474d482797ae5d
Disease	Anterior segment dysgenesis	PITX2 PITX3 PAX6	9.48e-07	8	77	3	cv:C1862839
Disease	anterior segment dysgenesis (implicated_via_orthology)	PITX3 TSC1	2.01e-05	3	77	2	DOID:0060648 (implicated_via_orthology)
Disease	Anophthalmia-microphthalmia syndrome	PITX2 PITX3 PAX6	2.20e-05	21	77	3	cv:C5680330
Disease	ANTERIOR SEGMENT DYSGENESIS 5	PITX2 PAX6	4.02e-05	4	77	2	C4310809
Disease	Axenfeld-Rieger Syndrome, Type 1	PITX2 PAX6	4.02e-05	4	77	2	C3714873
Disease	Cataract	PITX2 PITX3 PAX6	1.25e-04	37	77	3	C0086543
Disease	Irido-corneo-trabecular dysgenesis (disorder)	PITX2 PAX6	1.40e-04	7	77	2	C0344559
Disease	Odontome	PITX2 PAX6	2.98e-04	10	77	2	C0524730
Disease	Tooth Abnormalities	PITX2 PAX6	2.98e-04	10	77	2	C0040427
Disease	Cocaine Abuse	PITX3 SMAD1 SMAD5 OPRM1	3.47e-04	127	77	4	C0009171
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	HOOK1 SYNE1	4.36e-04	12	77	2	DOID:11726 (implicated_via_orthology)
Disease	juvenile polyposis syndrome (implicated_via_orthology)	SMAD1 SMAD5	5.15e-04	13	77	2	DOID:0050787 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	TAOK2 LAMC3 TSC1 OPRM1	6.84e-04	152	77	4	DOID:0060041 (implicated_via_orthology)
Disease	phospholipids:total lipids ratio, intermediate density lipoprotein measurement	ZNF106 TIMD4 JMJD1C	7.26e-04	67	77	3	EFO_0008595, EFO_0020946
Disease	juvenile idiopathic arthritis	NPHP4 JMJD1C SMAD1	9.69e-04	74	77	3	EFO_0002609
Disease	mean reticulocyte volume	KLF10 TIMD4 HOOK1 ZNF638 IDUA KLRC1 JMJD1C NUP205	1.13e-03	799	77	8	EFO_0010701
Disease	Epilepsy, Cryptogenic	ANKRD11 TSC1 OPRM1	1.30e-03	82	77	3	C0086237
Disease	Awakening Epilepsy	ANKRD11 TSC1 OPRM1	1.30e-03	82	77	3	C0751111
Disease	Aura	ANKRD11 TSC1 OPRM1	1.30e-03	82	77	3	C0236018
Disease	Pseudoaphakia	PITX3 PAX6	1.79e-03	24	77	2	C0524524
Disease	Lens Opacities	PITX3 PAX6	1.79e-03	24	77	2	C1510497
Disease	Brain Diseases	LAMC3 TSC1	1.94e-03	25	77	2	C0006111
Disease	cataract (is_implicated_in)	PITX3 PAX6	2.10e-03	26	77	2	DOID:83 (is_implicated_in)
Disease	Encephalopathies	LAMC3 TSC1	2.26e-03	27	77	2	C0085584
Disease	Disorder of eye	PITX2 PITX3 PAX6 NPHP4	2.33e-03	212	77	4	C0015397
Disease	cortical thickness	FLII ZNF106 CCDC88A FAR2 LAMC3 TMEM131 FIGLA IDUA JMJD1C	2.42e-03	1113	77	9	EFO_0004840
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	ZNF106 TIMD4 JMJD1C	2.51e-03	103	77	3	EFO_0008595, EFO_0020944

Protein segments in the cluster

Peptide	Gene	Start	Entry
SQHRQFQARVSRQTL	BUB1B	191	O60566
RTQQQRDNTVHSFRA	DDX52	446	Q9Y2R4
IQNRIQAITNHSIRQ	nan	551	Q9N2K0
AQHPRKRRFQRSTQQ	ANKRD11	2381	Q6UB99
QLRRAATAHRDQNRN	APBB1	76	O00213
TRAQRQRLQKQLTEH	CCDC22	241	O60826
ASTSHNRRVSNIQNV	ASPM	161	Q8IZT6
HSRQNTNRTGRIRTL	ATXN7L1	846	Q9ULK2
THRSNVQRQQIRQTF	ANXA6	391	P08133
LHVRSRNQVVLSRQL	CCDC69	226	A6NI79
QASRSRQNQREAHFI	FGF17	161	O60258
TLIQRHNNSSLNTRT	KLRC1	96	P26715
VTSLNRQRSHTQRLL	NUP205	1126	Q92621
LRNQRRQASNTPSHI	PAX6	271	P26367
LRHAVQLNVTATRQL	FAR2	121	Q96K12
HRRLLHQRQQQNRSQ	PATL1	361	Q86TB9
EQQNSTRIRQNTRDH	OPRM1	361	P35372
QTLHLRSTQRTQSNL	FLII	201	Q13045
RKLQQSSQLVHRRVQ	IL17REL	246	Q6ZVW7
SRNTVLQQHLETLRQ	HMG20A	276	Q9NP66
RRRSRANQNVNAVHS	JMJD1C	261	Q15652
EHLNQTVSSLRQRSQ	CCDC88A	561	Q3V6T2
RRNHQRAVESLQASL	MYH7B	1636	A7E2Y1
TLSNINAHIRRRIQS	PLXNA3	341	P51805
VNRNRISTARRVQHT	PHRF1	286	Q9P1Y6
LHSALVKSRQVNRNN	SLC11A2	271	P49281
RSINAQHTQRLLRIQ	NR1I2	401	O75469
THQQVVSRIRAALNA	SLC9A3R1	71	O14745
TSVLAQQSVRTQHLR	NPHP4	936	O75161
ARSHLRARVQAQSTN	NEU2	236	Q9Y3R4
TLRQQLQTTRQELSH	PRPF19	91	Q9UMS4
VSRFAIRSQHQQLEQ	GBX2	331	P52951
ISLANQRTITIHNRS	HYDIN	311	Q4G0P3
HQRSINTAVRATLSQ	ARFGEF3	151	Q5TH69
LARTVSRQQQQQHLH	FAM120C	26	Q9NX05
KHRSNRQLGIQQTTV	ECM2	46	O94769
AQRTLTARFQVNNTR	IDUA	361	P35475
QNNSFRRRTHLNVEA	KLF10	181	Q13118
AHNIQRRENTQQHIT	CTSG	76	P08311
RRENTQQHITARRAI	CTSG	81	P08311
QRTLLQHVAQSQTAT	EMSY	866	Q7Z589
TSSARQLSRNITQHI	FIGLA	146	Q6QHK4
AQQRHITNTRRNLSV	HOOK1	706	Q9UJC3
LQQNRLHRQSVETAR	CEP295	586	Q9C0D2
QQNVSSHREVRQRQQ	EGFEM1P	161	Q0D2K5
RRRNVTFSQQVANIL	SLC45A1	506	Q9Y2W3
KQRRQRTHFTSQQLQ	PITX3	61	O75364
RAHLSQQRRLKQATQ	NRIP2	76	Q9BQI9
SQASQRRHSRDQAQA	RSPH6A	21	Q9H0K4
NIFHKEQQRTSAQRR	SPACA7	176	Q96KW9
HLSNTVRSQNDNRER	PSEN1	21	P49768
RRQSNRATKEIQLHQ	SYNE1	3626	Q8NF91
ASLSAQQEAQHRRQR	NHSL2	541	Q5HYW2
QQEAQHRRQRSKSIS	NHSL2	546	Q5HYW2
RKTSYAQHQQVRQIR	RPS3A	151	P61247
FQQTLRRQRQHLQQS	SIMC1	581	Q8NDZ2
QAVQRTRAELTRLQH	TAOK2	696	Q9UL54
VRIRTISRNQAHLND	TENM1	1516	Q9UKZ4
RHQYRALINSVQQNR	NSMCE4A	86	Q9NXX6
RRQRTHFTSQQLQEL	PITX2	86	Q99697
QHNRRLRNLIATAQA	SUPT7L	71	O94864
NVNRNSTIENTRRHI	SMAD5	316	Q99717
NVNRNSTIENTRRHI	SMAD1	316	Q15797
TRRVRNINGITQHKQ	SRRT	501	Q9BXP5
NRSHVLQQTQRLDTS	TSC1	891	Q92574
SQTQANARAIHRLRK	TMC8	616	Q8IU68
TNITVLNLTHNQLRR	TLR3	51	O15455
RLANTQRNVHIQESF	RILPL1	366	Q5EBL4
QTVVLSHRNTRNLAA	RP1L1	166	Q8IWN7
RESQHSRSQRVTVLQ	TASL	71	Q9HAI6
RSFNQRSILNRHQKT	ZSCAN25	521	Q6NSZ9
HNRTVSSLIIVRNNL	TMEM131	946	Q92545
QHRSLTRQSRRQICT	ZDBF2	26	Q9HCK1
RERRNHETTNLSIQQ	SENP6	721	Q9GZR1
RIHRAINDNTNSRVV	TMED2	156	Q15363
RAENVATQRRHSAQL	ZNF106	926	Q9H2Y7
NVRLNLQRASTTTHR	TIMD4	126	Q96H15
NTSTHIESCRQLRQQ	ZNF638	446	Q14966
QSRQLLDQSRARHQA	TTLL5	1161	Q6EMB2
RQRSQLTQHQRLHTG	ZNF461	311	Q8TAF7
RVQIIQTSTNTSHRR	KRT77	561	Q7Z794
QAHRRASRLTSQTQA	LAMC3	1421	Q9Y6N6
GQSFRQRSNLLQHQR	MZF1	446	P28698