Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	endopolyphosphatase activity	NUDT11 NUDT4 NUDT10 NUDT4B	1.75e-09	5	88	4	GO:0000298
GeneOntologyMolecularFunction	bis(5'-adenosyl)-hexaphosphatase activity	NUDT11 NUDT4 NUDT10 NUDT4B	1.75e-09	5	88	4	GO:0034431
GeneOntologyMolecularFunction	diphosphoinositol-polyphosphate diphosphatase activity	NUDT11 NUDT4 NUDT10 NUDT4B	1.75e-09	5	88	4	GO:0008486
GeneOntologyMolecularFunction	bis(5'-adenosyl)-pentaphosphatase activity	NUDT11 NUDT4 NUDT10 NUDT4B	5.25e-09	6	88	4	GO:0034432
GeneOntologyMolecularFunction	four-way junction DNA binding	HMGB3 MSH2 FANCM	7.62e-05	19	88	3	GO:0000400
GeneOntologyMolecularFunction	ribose phosphate diphosphokinase activity	PRPSAP1 PRPSAP2	1.90e-04	5	88	2	GO:0004749
GeneOntologyMolecularFunction	diphosphotransferase activity	PRPSAP1 PRPSAP2	2.85e-04	6	88	2	GO:0016778
GeneOntologyMolecularFunction	pyrophosphatase activity	DNAH3 NUDT11 NUDT4 LONP2 LSG1 RHOBTB3 NUDT10 EIF5B MSH2 FANCM NUDT4B DDX39B	3.05e-04	839	88	12	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	DNAH3 NUDT11 NUDT4 LONP2 LSG1 RHOBTB3 NUDT10 EIF5B MSH2 FANCM NUDT4B DDX39B	3.08e-04	840	88	12	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	DNAH3 NUDT11 NUDT4 LONP2 LSG1 RHOBTB3 NUDT10 EIF5B MSH2 FANCM NUDT4B DDX39B	3.08e-04	840	88	12	GO:0016818
GeneOntologyMolecularFunction	DNA secondary structure binding	HMGB3 MSH2 FANCM	7.81e-04	41	88	3	GO:0000217
GeneOntologyBiologicalProcess	adenosine 5'-(hexahydrogen pentaphosphate) metabolic process	NUDT11 NUDT4 NUDT10 NUDT4B	1.34e-09	5	85	4	GO:1901910
GeneOntologyBiologicalProcess	adenosine 5'-(hexahydrogen pentaphosphate) catabolic process	NUDT11 NUDT4 NUDT10 NUDT4B	1.34e-09	5	85	4	GO:1901911
GeneOntologyBiologicalProcess	diadenosine pentaphosphate catabolic process	NUDT11 NUDT4 NUDT10 NUDT4B	1.34e-09	5	85	4	GO:1901907
GeneOntologyBiologicalProcess	diadenosine pentaphosphate metabolic process	NUDT11 NUDT4 NUDT10 NUDT4B	1.34e-09	5	85	4	GO:1901906
GeneOntologyBiologicalProcess	diadenosine hexaphosphate catabolic process	NUDT11 NUDT4 NUDT10 NUDT4B	1.34e-09	5	85	4	GO:1901909
GeneOntologyBiologicalProcess	diadenosine hexaphosphate metabolic process	NUDT11 NUDT4 NUDT10 NUDT4B	1.34e-09	5	85	4	GO:1901908
GeneOntologyBiologicalProcess	diphosphoinositol polyphosphate metabolic process	NUDT11 NUDT4 NUDT10 NUDT4B	1.34e-09	5	85	4	GO:0071543
GeneOntologyBiologicalProcess	diadenosine polyphosphate catabolic process	NUDT11 NUDT4 NUDT10 NUDT4B	4.00e-09	6	85	4	GO:0015961
GeneOntologyBiologicalProcess	diadenosine polyphosphate metabolic process	NUDT11 NUDT4 NUDT10 NUDT4B	3.33e-08	9	85	4	GO:0015959
GeneOntologyBiologicalProcess	inositol phosphate metabolic process	NUDT11 NUDT4 NUDT10 NUDT4B	6.25e-05	52	85	4	GO:0043647
GeneOntologyBiologicalProcess	polyol metabolic process	NUDT11 NUDT4 ASAH2 NUDT10 NUDT4B	1.56e-04	123	85	5	GO:0019751
GeneOntologyBiologicalProcess	purine nucleotide metabolic process	PRPSAP1 PRPSAP2 NUDT11 NUDT4 FAR2 PARP16 ACSS1 NUDT10 RORA NUDT4B	2.28e-04	619	85	10	GO:0006163
GeneOntologyBiologicalProcess	5-phosphoribose 1-diphosphate metabolic process	PRPSAP1 PRPSAP2	2.49e-04	6	85	2	GO:0046391
GeneOntologyBiologicalProcess	5-phosphoribose 1-diphosphate biosynthetic process	PRPSAP1 PRPSAP2	2.49e-04	6	85	2	GO:0006015
GeneOntologyBiologicalProcess	purine-containing compound metabolic process	PRPSAP1 PRPSAP2 NUDT11 NUDT4 FAR2 PARP16 ACSS1 NUDT10 RORA NUDT4B	3.44e-04	652	85	10	GO:0072521
GeneOntologyBiologicalProcess	ribose phosphate metabolic process	PRPSAP1 PRPSAP2 NUDT11 NUDT4 FAR2 ACSS1 NUDT10 RORA NUDT4B	3.81e-04	540	85	9	GO:0019693
Domain	NUDIX_hydrolase_CS	NUDT11 NUDT4 NUDT10	1.88e-05	12	84	3	IPR020084
Domain	NUDIX_BOX	NUDT11 NUDT4 NUDT10	1.66e-04	24	84	3	PS00893
Domain	NUDIX	NUDT11 NUDT4 NUDT10	1.66e-04	24	84	3	PF00293
Domain	Rib-P_diPkinase	PRPSAP1 PRPSAP2	1.98e-04	5	84	2	IPR005946
Domain	Pribosyltran_N	PRPSAP1 PRPSAP2	1.98e-04	5	84	2	IPR029099
Domain	ERCC4	EME1 FANCM	1.98e-04	5	84	2	SM00891
Domain	Pribosyltran_N	PRPSAP1 PRPSAP2	1.98e-04	5	84	2	PF13793
Domain	ERCC4_domain	EME1 FANCM	1.98e-04	5	84	2	IPR006166
Domain	ERCC4	EME1 FANCM	1.98e-04	5	84	2	PF02732
Domain	Pribosyl_synth	PRPSAP1 PRPSAP2	1.98e-04	5	84	2	PF14572
Domain	NUDIX	NUDT11 NUDT4 NUDT10	2.12e-04	26	84	3	PS51462
Domain	-	NUDT11 NUDT4 NUDT10	2.65e-04	28	84	3	3.90.79.10
Domain	NUDIX_hydrolase_dom-like	NUDT11 NUDT4 NUDT10	2.65e-04	28	84	3	IPR015797
Domain	NUDIX_hydrolase_dom	NUDT11 NUDT4 NUDT10	2.95e-04	29	84	3	IPR000086
Domain	Pribosyltran	PRPSAP1 PRPSAP2	1.07e-03	11	84	2	PF00156
Domain	PRTase-like	PRPSAP1 PRPSAP2	1.28e-03	12	84	2	IPR029057
Domain	PRibTrfase_dom	PRPSAP1 PRPSAP2	1.28e-03	12	84	2	IPR000836
Domain	-	PRPSAP1 PRPSAP2	1.28e-03	12	84	2	3.40.50.2020
Domain	-	DNAH3 LONP2 LSG1 RHOBTB3 EIF5B MSH2 FANCM ZFYVE1 DDX39B HYDIN	1.86e-03	746	84	10	3.40.50.300
Domain	FKBP_PPIASE	FKBP2 FKBP14	2.30e-03	16	84	2	PS50059
Domain	FKBP_C	FKBP2 FKBP14	2.30e-03	16	84	2	PF00254
Domain	PPIase_FKBP	FKBP2 FKBP14	2.60e-03	17	84	2	IPR023566
Domain	UIM	STAM2 ANKIB1	2.92e-03	18	84	2	PF02809
Domain	PUA-like_domain	LONP2 MCTS1	3.25e-03	19	84	2	IPR015947
Domain	Apc4_WD40_dom	WDR3 EML6	3.60e-03	20	84	2	IPR024977
Domain	ANAPC4_WD40	WDR3 EML6	3.60e-03	20	84	2	PF12894
Domain	PPIase_FKBP_dom	FKBP2 FKBP14	3.60e-03	20	84	2	IPR001179
Domain	UIM	STAM2 ANKIB1	3.97e-03	21	84	2	SM00726
Domain	P-loop_NTPase	DNAH3 LONP2 LSG1 RHOBTB3 EIF5B MSH2 FANCM ZFYVE1 DDX39B HYDIN	4.67e-03	848	84	10	IPR027417
Domain	UIM	STAM2 ANKIB1	5.17e-03	24	84	2	PS50330
Domain	UIM_dom	STAM2 ANKIB1	5.61e-03	25	84	2	IPR003903
Domain	Spectrin_repeat	DSP ACTN4	7.50e-03	29	84	2	IPR002017
Pathway	REACTOME_SYNTHESIS_OF_PYROPHOSPHATES_IN_THE_CYTOSOL	NUDT11 NUDT4 NUDT10	9.98e-06	10	63	3	MM14709
Pathway	REACTOME_SYNTHESIS_OF_PYROPHOSPHATES_IN_THE_CYTOSOL	NUDT11 NUDT4 NUDT10	9.98e-06	10	63	3	M27051
Pubmed	Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases.	NUDT11 NUDT4 NUDT10	1.62e-08	3	89	3	12121577
Pubmed	Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate.	NUDT11 NUDT4 NUDT10	6.47e-08	4	89	3	12370170
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	NEFM EME1 CCDC185 DSP LSG1 MCTS1 EML6 MANF ANKRD30A EIF5B NIPSNAP2 HMGB3 ACTN4 DDX39B HNRNPCL3 CHUK	7.11e-07	1442	89	16	35575683
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	LONP2 LSG1 RHOBTB3 ANKIB1 HNRNPCL4 SRPK2 YY1AP1 CRYBG3 METTL16 AP4B1 HNRNPCL3	8.72e-07	650	89	11	38777146
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	NEFM WDR3 DNAH3 RARS1 DSP MCTS1 NIPSNAP2 SRPK2 ACTN4 MSH2 PSME2 DDX39B	1.72e-06	847	89	12	35235311
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	RAB3GAP1 SH3PXD2B DSP PARP16 LSG1 ZC3H15 VPS13C SPART PLEKHA1 FNDC3A	2.00e-06	568	89	10	37774976
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	PRPSAP1 PRPSAP2 RIF1 RARS1 DSP LONP2 LSG1 ZC3H15 EIF5B NIPSNAP2 SRPK2 ACTN4 MSH2 PSME2 DDX39B	2.90e-06	1415	89	15	28515276
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	PIAS4 CCNT1 EME1 RARS1 DSP SPART ACTN4 DDX39B	3.91e-06	357	89	8	37059091
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	NEFM WDR3 NPRL2 KANSL2 VWF DSP RHOBTB3 ZNF451 SERGEF SRPK2 YY1AP1 ACTN4 ZNF785 CHUK	4.73e-06	1285	89	14	35914814
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	WDR3 STAM2 RAB3GAP1 R3HCC1L MAP2 LSG1 ZC3H15 ZNF451 EIF5B SPART PLEKHA1 SRPK2 FNDC3A CRYBG3 RB1CC1	5.28e-06	1487	89	15	33957083
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	WDR3 CCNT1 RIF1 DSP ZC3H15 ZNF451 MANF EIF5B HMGB3 FANCM DDX39B HNRNPCL3	5.79e-06	954	89	12	36373674
Pubmed	An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase.	NUDT11 NUDT10	6.48e-06	2	89	2	12105228
Pubmed	Spatial interplay between PIASy and FIP200 in the regulation of signal transduction and transcriptional activity.	PIAS4 RB1CC1	6.48e-06	2	89	2	18285457
Pubmed	Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolases.	NUDT11 NUDT10	6.48e-06	2	89	2	12689335
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	PRPSAP1 PRPSAP2 STAM2 RAB3GAP1 RARS1 MAP2 MCTS1 EIF5B HMGB3 ACTN4 MSH2 PSME2 DDX39B CHUK	1.91e-05	1455	89	14	22863883
Pubmed	Target deletion of the cytoskeleton-associated protein palladin does not impair neurite outgrowth in mice.	NEFM MAP2	1.94e-05	3	89	2	19730728
Pubmed	Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization.	NEFM MAP2	1.94e-05	3	89	2	11581286
Pubmed	Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction.	VWF MAP2	1.94e-05	3	89	2	12556486
Pubmed	Vinculin knockout results in heart and brain defects during embryonic development.	NEFM MAP2	1.94e-05	3	89	2	9486805
Pubmed	Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2.	NUDT4 NUDT4B	1.94e-05	3	89	2	11376937
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	WDR3 CCNT1 RIF1 FAM120C EIF5B YY1AP1 MSH2	2.83e-05	341	89	7	32971831
Pubmed	The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.	SH3PXD2B SERPINB8 SPART PLEKHA1 SRPK2 RB1CC1	2.88e-05	230	89	6	35449600
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	PRPSAP2 RAB3GAP1 RARS1 MAP2 DSP FAM120C UFC1 NIPSNAP2 ACTN4 CRYBG3 FKBP2 DDX39B	3.35e-05	1139	89	12	36417873
Pubmed	Expression of MUK/DLK/ZPK, an activator of the JNK pathway, in the nervous systems of the developing mouse embryo.	NEFM MAP2	3.87e-05	4	89	2	15749080
Pubmed	Dynamics of RIF1 SUMOylation is regulated by PIAS4 in the maintenance of Genomic Stability.	PIAS4 RIF1	3.87e-05	4	89	2	29234018
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	STAM2 RAB3GAP1 NUDT11 NUDT4 LSG1 ZC3H15 VPS13C MANF SPART PLEKHA1 INPP5F	5.29e-05	1007	89	11	34597346
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	PIAS4 WDR3 KIFAP3 CCNT1 RIF1 RARS1 DSP LSG1 ZNF451 FNDC3A ACTN4 ZNF317	5.66e-05	1203	89	12	29180619
Pubmed	New gene functions in megakaryopoiesis and platelet formation.	CFAP251 VWF FAR2 DOCK8	5.73e-05	81	89	4	22139419
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	FAM228B R3HCC1L NUDT4 DSP RHOBTB3 ZNF451 NUDT10 MANF PLEKHA1 KIAA1191 INPP5F ZNF785	6.23e-05	1215	89	12	15146197
Pubmed	Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.	NUDT11 NUDT10	6.44e-05	5	89	2	18264098
Pubmed	Human MutS and FANCM complexes function as redundant DNA damage sensors in the Fanconi Anemia pathway.	MSH2 FANCM	6.44e-05	5	89	2	21975120
Pubmed	Developmental and age-related changes of peptidylarginine deiminase 2 in the mouse brain.	NEFM MAP2	6.44e-05	5	89	2	19830834
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	STAM2 SH3PXD2B MAP2 DSP LSG1 MAP3K9 PLEKHA1 CRYBG3 KIAA1191 INPP5F	7.15e-05	861	89	10	36931259
Pubmed	Identification of host proteins required for HIV infection through a functional genomic screen.	CCNT1 FAM228B ANKRD30A NIPSNAP2 PSME2 ZNF785	7.31e-05	272	89	6	18187620
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	STAM2 DSP LSG1 ZC3H15 EIF5B SPART PLEKHA1 FNDC3A CRYBG3	8.51e-05	708	89	9	39231216
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	PRPSAP1 PRPSAP2 NEFM RIF1 RARS1 DSP RB1CC1 DDX39B	8.66e-05	551	89	8	34728620
Pubmed	SUMOylation of RORalpha potentiates transcriptional activation function.	PIAS4 RORA	9.65e-05	6	89	2	19041634
Pubmed	Interaction of Sp1 transcription factor with HIV-1 Tat protein: looking for cellular partners.	CCNT1 RIF1	9.65e-05	6	89	2	12753906
Pubmed	Ziploc-ing the structure 2.0: Endoplasmic reticulum-resident peptidyl prolyl isomerases show different activities toward hydroxyproline.	FKBP2 FKBP14	9.65e-05	6	89	2	28385890
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	RARS1 DSP EIF5B ACTN4 MSH2	9.99e-05	179	89	5	36261009
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	DNAH3 R3HCC1L RARS1 DSP FAM120C VPS13C MAP3K9 ZNF226 CHN1	1.14e-04	736	89	9	29676528
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	PRPSAP2 WDR3 RARS1 DSP ZC3H15 MANF EIF5B SPART SRPK2 ACTN4 PSME2 RB1CC1	1.15e-04	1297	89	12	33545068
Pubmed	Network organization of the human autophagy system.	NEFM RIF1 RAB3GAP1 UFC1 EIF5B NIPSNAP2 RB1CC1	1.34e-04	437	89	7	20562859
Pubmed	Expanding roles for alpha 4 integrin and its ligands in development.	NEFM VWF	1.35e-04	7	89	2	7526952
Pubmed	p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation.	NEFM MAP2	1.35e-04	7	89	2	11283609
Pubmed	The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development.	NEFM MAP2	1.35e-04	7	89	2	7956838
Pubmed	α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2.	MAP2 CHN1	1.35e-04	7	89	2	22138645
Pubmed	The cytoskeleton of the myenteric neurons during murine embryonic life.	NEFM MAP2	1.35e-04	7	89	2	10221457
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	CCNT1 STAM2 RIF1 R3HCC1L DSP LSG1 ZC3H15 EIF5B SPART PSME2	1.39e-04	934	89	10	33916271
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	WDR3 RARS1 DSP LSG1 EIF5B HNRNPCL4 ACTN4 RB1CC1 DDX39B HNRNPCL3	1.58e-04	949	89	10	36574265
Pubmed	Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.	PIAS4 EME1 ZNF451 MSH2	1.63e-04	106	89	4	19394292
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	PRPSAP2 NEFM RARS1 DSP MCTS1 EIF5B SPART HMGB3 SRPK2 ACTN4 DDX39B	1.69e-04	1149	89	11	35446349
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	PIAS4 CCNT1 RIF1 ZNF570 ZNF451 HMGB3 MSH2 ZNF226	1.70e-04	608	89	8	36089195
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	WDR3 CCNT1 RIF1 RAB3GAP1 RARS1 DSP LSG1 ANKIB1 EIF5B ACTN4 MSH2 DDX39B	1.71e-04	1353	89	12	29467282
Pubmed	Spatial, temporal and subcellular localization of islet-brain 1 (IB1), a homologue of JIP-1, in mouse brain.	NEFM MAP2	1.79e-04	8	89	2	10712642
Pubmed	The bHLH gene hes1 as a repressor of the neuronal commitment of CNS stem cells.	NEFM MAP2	1.79e-04	8	89	2	10627606
Pubmed	m5C methylated lncRncr3-MeCP2 interaction restricts miR124a-initiated neurogenesis.	NEFM MAP2	1.79e-04	8	89	2	38879605
Pubmed	Expression of the Prader-Willi gene Necdin during mouse nervous system development correlates with neuronal differentiation and p75NTR expression.	NEFM MAP2	2.30e-04	9	89	2	14643685
Pubmed	Purkinje Cell Degeneration and Motor Coordination Deficits in a New Mouse Model of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay.	MANF RORA	2.30e-04	9	89	2	28588446
Pubmed	Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold.	NEFM MAP2	2.30e-04	9	89	2	14532115
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	PIAS4 CCNT1 EME1 ZNF451 MSH2	2.72e-04	222	89	5	37071664
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	WDR3 RIF1 NUDT4 RARS1 DSP LSG1 ZC3H15 VPS13C EIF5B ACTN4 MSH2 DDX39B	2.75e-04	1425	89	12	30948266
Pubmed	Targeted inactivation of a developmentally regulated neural plectin isoform (plectin 1c) in mice leads to reduced motor nerve conduction velocity.	NEFM MAP2	2.88e-04	10	89	2	19625254
Pubmed	Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair.	RIF1 FANCM	2.88e-04	10	89	2	23509288
Pubmed	Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects.	NEFM VWF	2.88e-04	10	89	2	18992737
Pubmed	Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex.	NEFM MAP2	2.88e-04	10	89	2	17507397
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	NEFM SH3PXD2B MAP2 MCTS1 EIF5B MSH2 INPP5F	2.97e-04	498	89	7	36634849
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	PRPSAP1 STAM2 ZC3H15 MCTS1 EIF5B NIPSNAP2 KIAA1191 AP4B1 ZFYVE1 CHUK	3.24e-04	1038	89	10	26673895
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	PRPSAP1 CCNT1 RAB3GAP1 EIF5B SRPK2 FANCM FKBP2 DDX39B	3.26e-04	670	89	8	22990118
Pubmed	Genome-scale RNAi screen for host factors required for HIV replication.	CCNT1 NUDT4 ANKRD30A MAP3K9 RB1CC1 FANCM	3.38e-04	361	89	6	18976975
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	CCNT1 NPRL2 NUDT11 NUDT4 RARS1 EIF5B SRPK2 ACTN4 MSH2 PSME2 DDX39B	3.41e-04	1247	89	11	27684187
Pubmed	The LHX2-OTX2 transcriptional regulatory module controls retinal pigmented epithelium differentiation and underlies genetic risk for age-related macular degeneration.	NEFM TRPM1	3.51e-04	11	89	2	36649236
Pubmed	Multiple newly identified loci associated with prostate cancer susceptibility.	NUDT11 NUDT10	3.51e-04	11	89	2	18264097
Pubmed	Structural requirement of TAG-1 for retinal ganglion cell axons and myelin in the mouse optic nerve.	NEFM MAP2	3.51e-04	11	89	2	18650339
Pubmed	Mouse numb is an essential gene involved in cortical neurogenesis.	NEFM MAP2	3.51e-04	11	89	2	10841580
Pubmed	Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system.	NEFM MAP2	3.51e-04	11	89	2	11032813
Pubmed	Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis.	NEFM MAP2	4.20e-04	12	89	2	23861879
Pubmed	WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.	RB1CC1 ZFYVE1	4.20e-04	12	89	2	24954904
Pubmed	COUP-TFI is required for the formation of commissural projections in the forebrain by regulating axonal growth.	NEFM MAP2	4.20e-04	12	89	2	17021036
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	VPS13C RHOBTB3 ANKIB1 SPART FNDC3A INPP5F ZFYVE1	4.26e-04	529	89	7	14621295
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	PRPSAP1 RARS1 DSP ZC3H15 MANF PSME2 METTL16 DDX39B	4.83e-04	711	89	8	33022573
Pubmed	Serum Response Factor Is Essential for Maintenance of Podocyte Structure and Function.	VWF ACTN4	4.96e-04	13	89	2	29114040
Pubmed	Reticulons 1 and 3 are essential for axonal growth and synaptic maintenance associated with intellectual development.	NEFM MAP2	4.96e-04	13	89	2	37228035
Pubmed	Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.	EME1 MSH2	4.96e-04	13	89	2	25533185
Pubmed	A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein.	YY1AP1 RB1CC1	4.96e-04	13	89	2	17986458
Pubmed	Neural-specific inactivation of ShcA results in increased embryonic neural progenitor apoptosis and microencephaly.	NEFM MAP2	4.96e-04	13	89	2	16870734
Pubmed	Computational and experimental studies on human misshapen/NIK-related kinase MINK-1.	NEFM KIFAP3	4.96e-04	13	89	2	15032605
Pubmed	Plasticity-Related Gene 5 Is Expressed in a Late Phase of Neurodifferentiation After Neuronal Cell-Fate Determination.	NEFM MAP2	4.96e-04	13	89	2	35496908
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	CCNT1 RARS1 DOCK8 ZC3H15 MCTS1 EIF5B HMGB3 ACTN4 MSH2 PSME2	5.21e-04	1103	89	10	34189442
Pubmed	Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by affinity proteomics.	PRPSAP2 UFC1 MANF MSH2	5.38e-04	145	89	4	28846114
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	SH3PXD2B FAM120C LSG1 ZC3H15 EIF5B SPART ZFYVE1 DDX39B	5.44e-04	724	89	8	36232890
Pubmed	DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis.	DSP ACTN4 DDX39B	5.76e-04	63	89	3	37052853
Pubmed	The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex.	NEFM MAP2	5.78e-04	14	89	2	17108173
Pubmed	Distinct Activities of Tfap2A and Tfap2B in the Specification of GABAergic Interneurons in the Developing Cerebellum.	MAP2 RORA	5.78e-04	14	89	2	28912684
Pubmed	Filamin C is Essential for mammalian myocardial integrity.	DSP ACTN4	5.78e-04	14	89	2	36706168
Pubmed	MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex.	MAP2 MANF	5.78e-04	14	89	2	29082311
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	PRPSAP2 CCNT1 RARS1 PARP16 ZC3H15 MCTS1 EIF5B MSH2 PSME2 DDX39B HNRNPCL3	6.02e-04	1335	89	11	29229926
Pubmed	14-3-3ε mediates the cell fate decision-making pathways in response of hepatocellular carcinoma to Bleomycin-induced DNA damage.	PRPSAP1 PRPSAP2 ACTN4	6.60e-04	66	89	3	23472066
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	WDR3 CCNT1 DNAH3 LONP2 SRPK2 ACTN4	6.60e-04	410	89	6	26949251
Pubmed	Validation of genome-wide prostate cancer associations in men of African descent.	NUDT11 NUDT10	6.65e-04	15	89	2	21071540
Cytoband	Xp11.22	NUDT11 FAM120C XAGE1A	1.63e-04	54	89	3	Xp11.22
Cytoband	2q23.3	STAM2 RIF1	6.22e-04	19	89	2	2q23.3
Cytoband	14q24.2	MAP3K9 ZFYVE1	1.08e-03	25	89	2	14q24.2
Cytoband	15q22.2	VPS13C RORA	1.46e-03	29	89	2	15q22.2
Cytoband	12q13.11	CCNT1 KANSL2	1.77e-03	32	89	2	12q13.11
Cytoband	Ensembl 112 genes in cytogenetic band chr15q22	PARP16 VPS13C RORA	2.20e-03	132	89	3	chr15q22
Cytoband	5q35.1	SH3PXD2B RARS1	2.50e-03	38	89	2	5q35.1
GeneFamily	Nudix hydrolase family	NUDT11 NUDT4 NUDT10	4.88e-05	24	54	3	667
GeneFamily	FKBP prolyl isomerases	FKBP2 FKBP14	1.30e-03	18	54	2	910
Coexpression	GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_UP	PIAS4 PRPSAP2 CCNT1 ZNF570 MANF MSH2 ZNF317	4.78e-06	198	88	7	M4291
Coexpression	RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP	WDR3 STAM2 RIF1 RARS1 ZC3H15 ASAH2 RHOBTB3 EIF5B HMGB3 SRPK2 FKBP14	1.04e-05	644	88	11	M10501
Coexpression	FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP	WDR3 DNAH3 NUDT11 DSP FAM120C EML6 NUDT10 SPART RORA CHN1	2.77e-05	587	88	10	M40869
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	KIFAP3 RIF1 RAB3GAP1 RHOBTB3 ZNF451 SPART SRPK2 FNDC3A MSH2 CRYBG3 INPP5F RB1CC1	2.87e-05	856	88	12	M4500
Coexpression	GSE26928_NAIVE_VS_CENT_MEMORY_CD4_TCELL_UP	WDR3 KIFAP3 FAM120C PARP16 VPS13C RHOBTB3	4.70e-05	192	88	6	M4677
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP VPS13C ANKIB1 FNDC3A KIAA1191 RB1CC1	2.35e-06	191	89	6	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP VPS13C ANKIB1 FNDC3A KIAA1191 RB1CC1	2.35e-06	191	89	6	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP VPS13C ANKIB1 FNDC3A KIAA1191 RB1CC1	2.35e-06	191	89	6	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF613 NUDT10 HMGB3 KLK1 DKK2	1.16e-05	147	89	5	c8e5bdc3538089acd35a4b41390afaec0ac6d1aa
ToppCell	critical-Epithelial-unknown_epithelial\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	NEFM PARP16 KIAA1191 ZNF317 CHN1	1.80e-05	161	89	5	594cf3245ec065a7685db81cd8ba2cee8d42caac
ToppCell	NS-critical-d_16-33-Epithelial-unknown_epithelial\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NEFM PARP16 KIAA1191 ZNF317 CHN1	2.47e-05	172	89	5	c0b5e4889aef2f168d9f6db19a63b24bfd249316
ToppCell	facs-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEFM NUDT4 MAP2 NIPSNAP2 KLK1	2.47e-05	172	89	5	87a30a219b0a6979abb5fba292a2d8ea946fd849
ToppCell	facs-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEFM NUDT4 MAP2 NIPSNAP2 KLK1	2.47e-05	172	89	5	5030ac31709cac236bb58f4ef9d545d24690411a
Drug	diadenosine 5',5''''-P1,P6-hexaphosphate	NUDT11 NUDT10	1.48e-05	2	88	2	ctd:C070070
Drug	adenosine 5'-tetraphosphate	NUDT11 NUDT10	1.48e-05	2	88	2	ctd:C017991
Drug	adenosine 5'-pentaphosphate	NUDT11 NUDT10	1.48e-05	2	88	2	ctd:C048567
Disease	Arts syndrome (implicated_via_orthology)	PRPSAP1 PRPSAP2	7.63e-06	2	82	2	DOID:0050647 (implicated_via_orthology)
Disease	X-linked nonsyndromic deafness (implicated_via_orthology)	PRPSAP1 PRPSAP2	7.63e-06	2	82	2	DOID:0050566 (implicated_via_orthology)
Disease	pyroglutamine measurement	VWF FAR2 IAPP RHOBTB3	2.10e-05	58	82	4	EFO_0005408
Disease	Charcot-Marie-Tooth disease X-linked recessive 5 (implicated_via_orthology)	PRPSAP1 PRPSAP2	2.28e-05	3	82	2	DOID:0110210 (implicated_via_orthology)
Disease	platelet measurement	CFAP251 VWF FAR2 DOCK8 EML6 ACTN4	2.50e-04	315	82	6	EFO_0005036
Disease	neutrophil count	PRPSAP1 KIFAP3 FAM228B DOCK8 LSG1 SERGEF EML6 NIPSNAP2 SRPK2 YY1AP1 HYDIN	1.51e-03	1382	82	11	EFO_0004833
Disease	venous thromboembolism, plasminogen activator inhibitor 1 measurement	KIFAP3 VWF	1.55e-03	21	82	2	EFO_0004286, EFO_0004792
Disease	age at menopause	RIF1 SH3PXD2B FANCM ZFYVE1 CHUK	1.56e-03	302	82	5	EFO_0004704
Disease	venous thromboembolism, tissue plasminogen activator measurement	KIFAP3 VWF	1.86e-03	23	82	2	EFO_0004286, EFO_0004791
Disease	mitochondrial DNA measurement	CFAP251 SERPINB8 VWF FAR2 RB1CC1	2.23e-03	328	82	5	EFO_0006312
Disease	Bone Diseases, Developmental	SH3PXD2B CHUK	2.56e-03	27	82	2	C0005941

Protein segments in the cluster

Peptide	Gene	Start	Entry
CHIEGIKEAIKKKEQ	CCDC185	556	Q8N715
DPLQKKIIEKVCSHK	FAM228B	86	P0C875
LKKIVDEAVKHCPTV	ACSS1	231	Q9NUB1
IVPCVLKVKEAHETA	CRYBG3	1801	Q68DQ2
KDEEVLKKNCPHIVV	DDX39B	156	Q13838
VHKPPKVQEKCQLEI	ACTN4	341	O43707
CLPKATHQKEIDKIN	ANKRD30A	581	Q9BXX3
QKDVCLPKAAHQKEI	ANKRD30A	696	Q9BXX3
KDVCLPKATHQKEID	ANKRD30A	816	Q9BXX3
KELKKALCNPHIQAD	AP4B1	11	Q9Y6B7
PRHKIIKAACLVQQK	ANKIB1	706	Q9P2G1
AAKVEEQPKKLEHVI	CCNT1	91	O60563
PVLHQGEVCTKQRKK	DKK2	206	Q9UBU2
IKPCKLVHLQKEGIT	CFAP251	491	Q8TBY9
KVEDAIKVLQCHKPV	NUDT10	121	Q8NFP7
LQRHFKPKKVECLEV	R3HCC1L	136	Q7Z5L2
LPCVIHAAVLKVKEE	RAB3GAP1	781	Q15042
KICQEVLPKIHEDKH	NIPSNAP2	91	O75323
CPRIEFLQQKHKDEK	LRRC9	521	Q6ZRR7
VKHEKEAVICLQNEK	RB1CC1	916	Q8TDY2
EVKIEVLQKPFICHR	FKBP14	26	Q9NWM8
EKVKEVCPNVHEKIR	FAR2	66	Q96K12
SMPEQAHKVCVKEIK	LONP2	281	Q86WA8
KKDPVKIVRCHEHIE	MCTS1	46	Q9ULC4
DLKILPNDECKKAHV	KLK1	176	P06870
KKLHEENKQFLCIPR	LSG1	101	Q9H089
LQIGVKKRVDHCPIK	FKBP2	31	P26885
FKVEDAIKVLQCHKP	NUDT4B	121	A0A024RBG1
LEKIEKEHCKQGVEV	HNRNPCL3	201	B7ZW38
KKLNHANVVKACDVP	CHUK	66	O15111
QILGKPSEEIKECHK	ASAH2	486	Q9NR71
CAEIVKQTHIKPTKI	FANCM	836	Q8IYD8
KVEDAIKVLQCHKPV	NUDT4	121	Q9NZJ9
TDLKVQHKRVPCGKE	METTL16	351	Q86W50
LEKIEKEHCKQGVEV	HNRNPCL4	201	P0DMR1
KVEDAIKVLQCHKPV	NUDT11	121	Q96G61
VDKVPVVKAKATHVI	KIAA1191	91	Q96A73
KATPIESHQVEKRKC	IAPP	21	P10997
LAHHIPVEKICEKLK	MANF	96	P55145
EVIDHPDVKCQTKKK	PARP16	216	Q8N5Y8
VEKKVHPVTLNVKAE	HYDIN	4171	Q4G0P3
KPKVIIVQACRGEKH	CASP5	306	P51878
HDLDPRCVKPEVKVK	DOCK8	1196	Q8NF50
QPHLKKCFEGIAKLE	DNAH3	1196	Q8TD57
KAPKIEKVNDHICEI	FNDC3A	1051	Q9Y2H6
QDQKIVHKGDECILK	DSP	471	P15924
HVLTKGEIKIPVCIE	FAM120C	626	Q9NX05
QTCREEHKKKNPEVP	HMGB3	21	O15347
CIKHILEDKNAPFKQ	KANSL2	46	Q9H9L4
VPHEVQKLQCPKIKT	PRPSAP1	311	Q14558
HEVQKLQCPKIKTVD	PRPSAP2	326	O60256
KDKIFVVKCNPHHVD	EML6	816	Q6ZMW3
KAQRPEECLKHIIVV	EME1	241	Q96AY2
VPNDCKPDLKHVKKV	CHN1	251	P15882
KLPGDHEVCKVTKIA	INPP5F	76	Q9Y2H2
FPKHVIECAKQKALE	MSH2	836	P43246
IIIHQLCQEKPRVKK	MAP3K9	486	P80192
ARKVVEECKLIHPSK	KIFAP3	71	Q92845
PNLKKVVEAHKIVLC	RHOBTB3	261	O94955
ITKHLPDNECIEKVE	RARS1	141	P54136
RCVVPQAIELHKEKV	SERGEF	141	Q9UGK8
DHQKEVLKTKRCDIP	RIF1	1066	Q5UIP0
QEEFKHIAVFPCKIK	EIF5B	1081	O60841
GPVESHKIAQVKLCK	PNMA3	241	Q9UL41
DKQEKKEVHKCGFLP	PSME2	81	Q9UL46
EKKLIGCPVCIEHKK	NPRL2	61	Q8WTW4
KNVPLSKVAHKCFVE	SERPINB8	306	P50452
HEGVACVQKEKSVVK	ZNF451	456	Q9Y4E5
PDLIQKGVIQHKEKC	UFC1	151	Q9Y3C8
VANCVGKELAPHVKK	SPART	501	Q8N0X7
HPSVKCKKRVTILVE	VWF	916	P04275
KKTHTSQIEIIPCKI	RORA	61	P35398
LECGHKVLAKEVKKP	SH3PXD2B	596	A1X283
SKCKIIHTDIKPENI	SRPK2	206	P78362
LCAKEKNPHTVAEKL	ZBED8	101	Q8IZ13
TEVRAVIKNKAHPKV	STAM2	91	O75886
NIIVTDVDPKTVHKK	VPS13C	1131	Q709C8
IGVKHPELCKALVKE	PIAS4	291	Q8N2W9
KEKVAKPDLVHQEAV	MAP2	1111	P11137
KLDCKPDQHLKVVSI	ZFYVE1	171	Q9HBF4
IKEEKDVKTHLVPEC	TRPM1	1306	Q7Z4N2
QKEVEKVKPQCKEVH	YY1AP1	141	Q9H869
KVKPQCKEVHQTLIL	YY1AP1	146	Q9H869
PVHQKVHVGEKLKCD	ZNF226	296	Q9NYT6
LLCTQKIIPKEEKVH	ZNF570	176	Q96NI8
EIHSQICPEIKKVDN	ZNF613	71	Q6PF04
SGVKVKIIPKEEHCK	XAGE1A	56	Q9HD64
HGEAEKKKPKTQIVC	ZC3H15	166	Q8WU90
EHKAICKAAGKEVPL	WDR3	776	Q9UNX4
PLKEVHKVQECKQSD	PLEKHA1	236	Q9HB21
IHIVKKPVECRQCGK	ZNF317	411	Q96PQ6
CPKQKEVAHEVAVKE	ZNF785	126	A8K8V0
VEAPKLKVQHKFVEE	NEFM	441	P07197