Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncatecholamine binding

DRD1 DRD5 ADRB2

4.92e-0713253GO:1901338
GeneOntologyMolecularFunctiondopamine neurotransmitter receptor activity, coupled via Gs

DRD1 DRD5

1.50e-062252GO:0001588
GeneOntologyMolecularFunctionbradykinin receptor binding

ADRB2 AGTR1

4.51e-063252GO:0031711
GeneOntologyMolecularFunctionG protein-coupled receptor activity

MC4R OR2L8 DRD1 CCR8 DRD5 ADRB2 NMBR AGTR1

7.89e-06884258GO:0004930
GeneOntologyMolecularFunctiondopamine neurotransmitter receptor activity

DRD1 DRD5

1.50e-055252GO:0004952
GeneOntologyMolecularFunctionG-protein alpha-subunit binding

DRD1 DRD5 ADRB2

2.07e-0543253GO:0001965
GeneOntologyMolecularFunctiondopamine binding

DRD1 DRD5

3.15e-057252GO:0035240
GeneOntologyMolecularFunctionsymporter activity

SLC4A10 SLC28A3 SLC16A14 SLC39A8

3.42e-05150254GO:0015293
GeneOntologyMolecularFunctionmonoatomic cation:bicarbonate symporter activity

SLC4A10 SLC39A8

1.16e-0413252GO:0140410
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

MC4R OR2L8 DRD1 CCR8 DRD5 ADRB2 NMBR AGTR1

1.66e-041353258GO:0004888
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC4A10 SLC28A3 SLC39A8

4.31e-04119253GO:0015294
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC4A10 SLC25A32 SLC16A14 SLC39A8

4.50e-04293254GO:0008514
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC4A10 SLC28A3 SLC16A14 SLC39A8

4.68e-04296254GO:0015291
GeneOntologyMolecularFunctiondopamine receptor binding

DRD1 AGTR1

4.80e-0426252GO:0050780
GeneOntologyMolecularFunctionG protein-coupled peptide receptor activity

MC4R NMBR AGTR1

5.97e-04133253GO:0008528
GeneOntologyMolecularFunctionpeptide receptor activity

MC4R NMBR AGTR1

6.93e-04140253GO:0001653
GeneOntologyMolecularFunctionbicarbonate transmembrane transporter activity

SLC4A10 SLC39A8

7.29e-0432252GO:0015106
GeneOntologyMolecularFunctionG protein-coupled receptor binding

DRD1 ADRB2 RSPO1 AGTR1

7.62e-04337254GO:0001664
GeneOntologyMolecularFunctionnucleobase-containing compound transmembrane transporter activity

SLC25A32 SLC28A3

2.46e-0359252GO:0015932
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC4A10 SLC28A3 SLC16A14 SLC39A8

2.73e-03477254GO:0022804
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC4A10 BAX SLC25A32 SLC28A3 SLC16A14 SLC39A8

2.82e-031180256GO:0022857
GeneOntologyMolecularFunctionpostsynaptic neurotransmitter receptor activity

DRD1 DRD5

3.95e-0375252GO:0098960
GeneOntologyMolecularFunctiontransporter activity

SLC4A10 BAX SLC25A32 SLC28A3 SLC16A14 SLC39A8

4.37e-031289256GO:0005215
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC4A10 SLC28A3

4.59e-0381252GO:0015370
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC4A10 SLC28A3 SLC39A8

6.10e-03301253GO:0022853
GeneOntologyMolecularFunctionneurotransmitter receptor activity

DRD1 DRD5

6.91e-03100252GO:0030594
GeneOntologyMolecularFunctionhormone binding

MC4R SULT2B1

7.32e-03103252GO:0042562
GeneOntologyMolecularFunctioncytokine binding

CCR8 NRROS

1.64e-02157252GO:0019955
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC4A10 SLC28A3

1.92e-02171252GO:0015081
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC4A10 SLC28A3 SLC39A8

1.97e-02465253GO:0046873
GeneOntologyBiologicalProcessadenylate cyclase-activating adrenergic receptor signaling pathway

DRD1 DRD5 ADRB2

4.01e-0625263GO:0071880
GeneOntologyBiologicalProcesspositive regulation of calcium ion transmembrane transport

BAX DRD1 ADRB2 AGTR1

1.01e-05109264GO:1904427
GeneOntologyBiologicalProcessactivation of adenylate cyclase activity

DRD1 DRD5 ADRB2

1.04e-0534263GO:0007190
GeneOntologyBiologicalProcessadrenergic receptor signaling pathway

DRD1 DRD5 ADRB2

1.13e-0535263GO:0071875
GeneOntologyBiologicalProcesssensitization

DRD1 DRD5

1.52e-055262GO:0046960
GeneOntologyBiologicalProcesspositive regulation of adenylate cyclase activity

DRD1 DRD5 ADRB2

1.70e-0540263GO:0045762
GeneOntologyBiologicalProcessphospholipase C-activating G protein-coupled receptor signaling pathway

DRD1 DRD5 NMBR AGTR1

2.21e-05133264GO:0007200
GeneOntologyBiologicalProcesspositive regulation of cyclase activity

DRD1 DRD5 ADRB2

2.96e-0548263GO:0031281
GeneOntologyBiologicalProcesspositive regulation of lyase activity

DRD1 DRD5 ADRB2

3.15e-0549263GO:0051349
GeneOntologyBiologicalProcesspositive regulation of blood pressure by epinephrine-norepinephrine

DRD5 ADRB2

3.20e-057262GO:0003321
GeneOntologyBiologicalProcesspositive regulation of calcium ion transport

BAX DRD1 ADRB2 AGTR1

3.93e-05154264GO:0051928
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure by norepinephrine-epinephrine

DRD5 ADRB2

4.26e-058262GO:0001993
GeneOntologyBiologicalProcessanatomical structure homeostasis

MC4R BAX SLC28A3 ADRB2 SLC39A8

5.37e-05334265GO:0060249
GeneOntologyBiologicalProcesstissue homeostasis

MC4R BAX SLC28A3 ADRB2 SLC39A8

5.37e-05334265GO:0001894
GeneOntologyBiologicalProcessphospholipase C-activating dopamine receptor signaling pathway

DRD1 DRD5

5.47e-059262GO:0060158
GeneOntologyBiologicalProcesspositive regulation of blood pressure

DRD5 ADRB2 AGTR1

5.52e-0559263GO:0045777
GeneOntologyBiologicalProcessregulation of adenylate cyclase activity

DRD1 DRD5 ADRB2

5.52e-0559263GO:0045761
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure mediated by a chemical signal

DRD5 ADRB2 AGTR1

6.10e-0561263GO:0003044
GeneOntologyBiologicalProcesspositive regulation of cation transmembrane transport

BAX DRD1 ADRB2 AGTR1

6.33e-05174264GO:1904064
GeneOntologyBiologicalProcessregulation of cyclase activity

DRD1 DRD5 ADRB2

8.82e-0569263GO:0031279
GeneOntologyBiologicalProcessadenylate cyclase-activating G protein-coupled receptor signaling pathway

MC4R DRD1 DRD5 ADRB2

9.08e-05191264GO:0007189
GeneOntologyBiologicalProcesspositive regulation of monoatomic ion transmembrane transport

BAX DRD1 ADRB2 AGTR1

9.27e-05192264GO:0034767
GeneOntologyBiologicalProcessresponse to catecholamine

DRD1 DRD5 ADRB2

1.04e-0473263GO:0071869
GeneOntologyBiologicalProcessregulation of lyase activity

DRD1 DRD5 ADRB2

1.04e-0473263GO:0051339
GeneOntologyBiologicalProcessresponse to monoamine

DRD1 DRD5 ADRB2

1.09e-0474263GO:0071867
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

SLC4A10 BAX SLC28A3 DRD1 ADRB2 SLC39A8 AGTR1

1.09e-04922267GO:0098662
GeneOntologyBiologicalProcessblood vessel diameter maintenance

DRD1 DRD5 ADRB2 AGTR1

1.13e-04202264GO:0097746
GeneOntologyBiologicalProcessregulation of tube diameter

DRD1 DRD5 ADRB2 AGTR1

1.13e-04202264GO:0035296
GeneOntologyBiologicalProcessregulation of tube size

DRD1 DRD5 ADRB2 AGTR1

1.15e-04203264GO:0035150
GeneOntologyBiologicalProcesspositive regulation of calcium ion import across plasma membrane

ADRB2 AGTR1

1.18e-0413262GO:1905665
GeneOntologyBiologicalProcessnonassociative learning

DRD1 DRD5

1.18e-0413262GO:0046958
GeneOntologyBiologicalProcessadenylate cyclase-activating dopamine receptor signaling pathway

DRD1 DRD5

1.18e-0413262GO:0007191
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SLC4A10 BAX SLC28A3 DRD1 ADRB2 SLC39A8 AGTR1

1.24e-04942267GO:0098655
GeneOntologyBiologicalProcesscalcium ion transmembrane import into cytosol

BAX DRD1 ADRB2 AGTR1

1.49e-04217264GO:0097553
GeneOntologyBiologicalProcessregulation of calcium ion transmembrane transport

BAX DRD1 ADRB2 AGTR1

1.51e-04218264GO:1903169
GeneOntologyBiologicalProcessmetal ion transport

SLC4A10 BAX SLC28A3 DRD1 ADRB2 SLC39A8 AGTR1

1.80e-041000267GO:0030001
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

SLC4A10 BAX SLC28A3 DRD1 ADRB2 SLC39A8 AGTR1

2.00e-041017267GO:0098660
GeneOntologyBiologicalProcessmonoatomic cation homeostasis

SLC4A10 BAX DRD1 DRD5 SLC39A8 AGTR1

2.00e-04705266GO:0055080
GeneOntologyBiologicalProcessdiet induced thermogenesis

MC4R ADRB2

2.05e-0417262GO:0002024
GeneOntologyBiologicalProcessmonoatomic ion homeostasis

SLC4A10 BAX DRD1 DRD5 SLC39A8 AGTR1

2.19e-04717266GO:0050801
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

MC4R OR2L8 DRD1 CCR8 DRD5 ADRB2 NMBR AGTR1

2.23e-041395268GO:0007186
GeneOntologyBiologicalProcessmulticellular organismal-level homeostasis

MC4R BAX SLC28A3 DRD1 ADRB2 CRISPLD1 SLC39A8

2.34e-041043267GO:0048871
GeneOntologyBiologicalProcessregulation of calcium ion import across plasma membrane

ADRB2 AGTR1

2.58e-0419262GO:1905664
GeneOntologyBiologicalProcesspositive regulation of monoatomic ion transport

BAX DRD1 ADRB2 AGTR1

3.23e-04266264GO:0043270
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SLC4A10 BAX SLC28A3 DRD1 ADRB2 SLC39A8 AGTR1

3.51e-041115267GO:0034220
GeneOntologyBiologicalProcesspositive regulation of transmembrane transport

BAX DRD1 ADRB2 AGTR1

3.57e-04273264GO:0034764
GeneOntologyBiologicalProcessgrooming behavior

MC4R DRD1

4.15e-0424262GO:0007625
GeneOntologyBiologicalProcessadenylate cyclase-modulating G protein-coupled receptor signaling pathway

MC4R DRD1 DRD5 ADRB2

4.25e-04286264GO:0007188
GeneOntologyBiologicalProcessmonoatomic cation transport

SLC4A10 BAX SLC28A3 DRD1 ADRB2 SLC39A8 AGTR1

4.40e-041157267GO:0006812
GeneOntologyBiologicalProcessvasoconstriction

DRD1 DRD5 AGTR1

4.64e-04121263GO:0042310
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure

DRD5 ADRB2 AGTR1

4.98e-04124263GO:0003073
GeneOntologyBiologicalProcessassociative learning

DRD1 DRD5 ADRB2

5.72e-04130263GO:0008306
GeneOntologyBiologicalProcessregulation of calcium ion transport

BAX DRD1 ADRB2 AGTR1

6.72e-04323264GO:0051924
GeneOntologyBiologicalProcessbehavior

MC4R SLC4A10 DRD1 DRD5 ADRB2 AGTR1

7.00e-04891266GO:0007610
GeneOntologyBiologicalProcessinorganic ion import across plasma membrane

ADRB2 SLC39A8 AGTR1

7.40e-04142263GO:0099587
GeneOntologyBiologicalProcessinorganic cation import across plasma membrane

ADRB2 SLC39A8 AGTR1

7.40e-04142263GO:0098659
GeneOntologyBiologicalProcesspositive regulation of calcium ion import

ADRB2 AGTR1

8.36e-0434262GO:0090280
GeneOntologyBiologicalProcessvascular process in circulatory system

DRD1 DRD5 ADRB2 AGTR1

8.50e-04344264GO:0003018
GeneOntologyBiologicalProcessintracellular monoatomic cation homeostasis

SLC4A10 BAX DRD1 DRD5 SLC39A8

8.81e-04611265GO:0030003
GeneOntologyBiologicalProcesssynaptic transmission, dopaminergic

DRD1 DRD5

8.86e-0435262GO:0001963
GeneOntologyBiologicalProcessintracellular monoatomic ion homeostasis

SLC4A10 BAX DRD1 DRD5 SLC39A8

9.54e-04622265GO:0006873
GeneOntologyBiologicalProcessinorganic ion homeostasis

BAX DRD1 DRD5 SLC39A8 AGTR1

9.54e-04622265GO:0098771
GeneOntologyBiologicalProcessbicarbonate transport

SLC4A10 SLC39A8

1.04e-0338262GO:0015701
GeneOntologyBiologicalProcessfeeding behavior

MC4R DRD1 AGTR1

1.08e-03162263GO:0007631
GeneOntologyBiologicalProcessresponse to amphetamine

DRD1 DRD5

1.16e-0340262GO:0001975
GeneOntologyBiologicalProcessmonoatomic ion transport

SLC4A10 BAX SLC28A3 DRD1 ADRB2 SLC39A8 AGTR1

1.23e-031374267GO:0006811
GeneOntologyBiologicalProcessregulation of monoatomic cation transmembrane transport

BAX DRD1 ADRB2 AGTR1

1.23e-03380264GO:1904062
GeneOntologyBiologicalProcessresponse to light stimulus

SLC4A10 BAX DRD1 DRD5

1.25e-03382264GO:0009416
GeneOntologyBiologicalProcesscalcium ion transmembrane transport

BAX DRD1 ADRB2 AGTR1

1.38e-03392264GO:0070588
GeneOntologyBiologicalProcessG protein-coupled dopamine receptor signaling pathway

DRD1 DRD5

1.40e-0344262GO:0007212
GeneOntologyBiologicalProcesslong-term synaptic depression

DRD1 DRD5

1.40e-0344262GO:0060292
GeneOntologyBiologicalProcessnegative regulation of behavior

MC4R DRD1

1.46e-0345262GO:0048521
GeneOntologyBiologicalProcessresponse to dietary excess

MC4R ADRB2

1.60e-0347262GO:0002021
GeneOntologyBiologicalProcesscalcium ion import across plasma membrane

ADRB2 AGTR1

1.66e-0348262GO:0098703
GeneOntologyBiologicalProcesspositive regulation of release of sequestered calcium ion into cytosol

BAX DRD1

1.66e-0348262GO:0051281
GeneOntologyBiologicalProcesscalcium ion import into cytosol

ADRB2 AGTR1

1.66e-0348262GO:1902656
GeneOntologyBiologicalProcessregulation of monoatomic ion transmembrane transport

BAX DRD1 ADRB2 AGTR1

1.73e-03417264GO:0034765
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure by hormone

DRD5 AGTR1

1.88e-0351262GO:0001990
GeneOntologyBiologicalProcesstriglyceride biosynthetic process

CNEP1R1 AGMO

1.95e-0352262GO:0019432
GeneOntologyBiologicalProcessdopamine metabolic process

DRD1 AGTR1

2.02e-0353262GO:0042417
GeneOntologyBiologicalProcesspositive regulation of potassium ion transport

DRD1 ADRB2

2.10e-0354262GO:0043268
GeneOntologyBiologicalProcessmitochondrial transport

BAX SLC25A32 SLC39A8

2.13e-03205263GO:0006839
GeneOntologyBiologicalProcesseating behavior

MC4R DRD1

2.26e-0356262GO:0042755
GeneOntologyBiologicalProcessmating behavior

DRD1 DRD5

2.34e-0357262GO:0007617
GeneOntologyBiologicalProcesslearning

DRD1 DRD5 ADRB2

2.34e-03212263GO:0007612
GeneOntologyBiologicalProcessresponse to amine

DRD1 DRD5

2.42e-0358262GO:0014075
HumanPhenoOrthokeratotic hyperkeratosis

SULT2B1 RSPO1

8.85e-057112HP:0025080
Domain7TM_GPCR_Srsx

MC4R DRD1 DRD5 ADRB2 NMBR AGTR1

8.48e-09112266SM01381
DomainGPCR_Rhodpsn_7TM

MC4R OR2L8 DRD1 CCR8 DRD5 ADRB2 NMBR AGTR1

2.32e-06670268IPR017452
Domain7tm_1

MC4R OR2L8 DRD1 CCR8 DRD5 ADRB2 NMBR AGTR1

2.50e-06677268PF00001
DomainG_PROTEIN_RECEP_F1_1

MC4R OR2L8 DRD1 CCR8 DRD5 ADRB2 NMBR AGTR1

2.73e-06685268PS00237
DomainG_PROTEIN_RECEP_F1_2

MC4R OR2L8 DRD1 CCR8 DRD5 ADRB2 NMBR AGTR1

2.91e-06691268PS50262
DomainGPCR_Rhodpsn

MC4R OR2L8 DRD1 CCR8 DRD5 ADRB2 NMBR AGTR1

2.95e-06692268IPR000276
DomainDopamine_rcpt

DRD1 DRD5

1.86e-055262IPR000929
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

MC4R DRD1 CCR8 DRD5 ADRB2 NMBR AGTR1

6.25e-08260217M39397
PathwayWP_GPCRS_NONODORANT

MC4R DRD1 CCR8 DRD5 ADRB2 NMBR AGTR1

7.30e-08266217MM15843
PathwayREACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS

MC4R DRD1 CCR8 DRD5 ADRB2 NMBR AGTR1

3.17e-07330217M18334
PathwayREACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS

MC4R DRD1 CCR8 DRD5 ADRB2 NMBR AGTR1

3.37e-07333217MM14963
PathwayREACTOME_GPCR_LIGAND_BINDING

MC4R DRD1 CCR8 DRD5 ADRB2 NMBR AGTR1

1.88e-06430217MM15160
PathwayKEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION

MC4R DRD1 DRD5 ADRB2 NMBR AGTR1

2.08e-06272216M13380
PathwayREACTOME_GPCR_LIGAND_BINDING

MC4R DRD1 CCR8 DRD5 ADRB2 NMBR AGTR1

3.07e-06463217M507
PathwayWP_GPCRS_PEPTIDE

MC4R CCR8 NMBR AGTR1

3.13e-0670214MM15959
PathwayWP_PEPTIDE_GPCRS

MC4R CCR8 NMBR AGTR1

4.13e-0675214M39696
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

MC4R CCR8 ADRB2 NMBR AGTR1

6.50e-06186215MM15994
PathwayWP_GPCRS_OTHER

MC4R DRD1 DRD5 ADRB2

1.11e-0596214MM15939
PathwayWP_ADHD_AND_AUTISM_ASD_PATHWAYS

MC4R SLC25A32 DRD5 ADRB2 AGMO AGTR1

1.16e-05367216M48346
PathwayWP_MONOAMINE_GPCRS

DRD1 DRD5 ADRB2

1.25e-0531213MM15871
PathwayWP_MONOAMINE_GPCRS

DRD1 DRD5 ADRB2

1.51e-0533213M39585
PathwayREACTOME_DOPAMINE_RECEPTORS

DRD1 DRD5

2.11e-055212M27301
PathwayREACTOME_DOPAMINE_RECEPTORS

DRD1 DRD5

2.11e-055212MM15007
PathwayREACTOME_SIGNALING_BY_GPCR

MC4R DRD1 CCR8 DRD5 ADRB2 NMBR AGTR1

2.72e-05646217MM14962
PathwayREACTOME_AMINE_LIGAND_BINDING_RECEPTORS

DRD1 DRD5 ADRB2

3.15e-0542213M5868
PathwayREACTOME_AMINE_LIGAND_BINDING_RECEPTORS

DRD1 DRD5 ADRB2

3.15e-0542213MM14971
PathwayREACTOME_SIGNALING_BY_GPCR

MC4R DRD1 CCR8 DRD5 ADRB2 NMBR AGTR1

4.64e-05702217M746
PathwayREACTOME_G_ALPHA_S_SIGNALLING_EVENTS

MC4R DRD1 DRD5 ADRB2

5.31e-05143214MM15055
PathwayREACTOME_G_ALPHA_S_SIGNALLING_EVENTS

MC4R DRD1 DRD5 ADRB2

7.64e-05157214M4904
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

DRD1 DRD5 ADRB2 AGTR1

1.24e-04178214M2890
PathwayREACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS

MC4R CCR8 NMBR AGTR1

1.84e-04197214M12289
PathwayREACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS

MC4R CCR8 NMBR AGTR1

1.84e-04197214MM14970
PathwayPID_ARF6_PATHWAY

ADRB2 AGTR1

1.22e-0335212M86
PathwayPID_ARF6_TRAFFICKING_PATHWAY

ADRB2 AGTR1

2.38e-0349212M67
Pubmed

Differential D1 and D5 receptor regulation and degradation of the angiotensin type 1 receptor.

DRD1 DRD5 AGTR1

3.71e-10326318172057
Pubmed

Redundant catecholamine signaling consolidates fear memory via phospholipase C.

DRD1 DRD5 ADRB2

3.70e-09526322323706
Pubmed

Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.

DRD1 CCR8 DRD5 ADRB2 NMBR AGTR1

7.02e-0920026618240029
Pubmed

Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.

MC4R DRD1 DRD5 ADRB2

2.18e-077026412036966
Pubmed

The third intracellular loop of D1 and D5 dopaminergic receptors dictates their subtype-specific PKC-induced sensitization and desensitization in a receptor conformation-dependent manner.

DRD1 DRD5

5.37e-07226221893192
Pubmed

Activation of D1/5 Dopamine Receptors: A Common Mechanism for Enhancing Extinction of Fear and Reward-Seeking Behaviors.

DRD1 DRD5

5.37e-07226226763483
Pubmed

Differentiation of forebrain and hippocampal dopamine 1-class receptors, D1R and D5R, in spatial learning and memory.

DRD1 DRD5

5.37e-07226226174222
Pubmed

PV plasticity sustained through D1/5 dopamine signaling required for long-term memory consolidation.

DRD1 DRD5

5.37e-07226226807952
Pubmed

Role of the extracellular amino terminus and first membrane-spanning helix of dopamine D1 and D5 receptors in shaping ligand selectivity and efficacy.

DRD1 DRD5

5.37e-07226219786093
Pubmed

The cooperative roles of the dopamine receptors, D1R and D5R, on the regulation of renal sodium transport.

DRD1 DRD5

5.37e-07226224552847
Pubmed

D1/D5 modulation of synaptic NMDA receptor currents.

DRD1 DRD5

5.37e-07226219279248
Pubmed

Functional importance of two conserved residues in intracellular loop 1 and transmembrane region 2 of Family A GPCRs: insights from ligand binding and signal transduction responses of D1 and D5 dopaminergic receptor mutants.

DRD1 DRD5

5.37e-07226226186971
Pubmed

AT(1) receptor Gαq protein-independent signalling transcriptionally activates only a few genes directly, but robustly potentiates gene regulation from the β2-adrenergic receptor.

ADRB2 AGTR1

5.37e-07226220708651
Pubmed

Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory.

DRD1 DRD5

5.37e-07226224843151
Pubmed

Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor.

DRD1 DRD5

5.37e-0722621831904
Pubmed

Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity.

DRD1 DRD5

5.37e-07226213679419
Pubmed

Dopamine D1 and D5 receptors modulate spike timing-dependent plasticity at medial perforant path to dentate granule cell synapses.

DRD1 DRD5

5.37e-07226225429131
Pubmed

Specific role of dopamine D1 receptors in spinal network activation and rhythmic movement induction in vertebrates.

DRD1 DRD5

5.37e-07226219204052
Pubmed

Agonist-dependent and -independent dopamine-1-like receptor signalling differentially regulates downstream effectors.

DRD1 DRD5

5.37e-07226225154512
Pubmed

Role of D1-like receptors in amphetamine-induced behavioral sensitization: a study using D1A receptor knockout mice.

DRD1 DRD5

5.37e-07226211823893
Pubmed

Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells.

DRD5 AGTR1

5.37e-07226218464932
Pubmed

Dopamine receptor ligands. Part 18: (1) modification of the structural skeleton of indolobenzazecine-type dopamine receptor antagonists.

DRD1 DRD5

5.37e-07226220180564
Pubmed

Differential dependence of the D1 and D5 dopamine receptors on the G protein gamma 7 subunit for activation of adenylylcyclase.

DRD1 DRD5

5.37e-07226211500503
Pubmed

Identification of a cyclic adenosine 3',5'-monophosphate-dependent protein kinase phosphorylation site in the carboxy terminal tail of human D1 dopamine receptor.

DRD1 DRD5

1.61e-0632627609904
Pubmed

Calcium signaling by dopamine D5 receptor and D5-D2 receptor hetero-oligomers occurs by a mechanism distinct from that for dopamine D1-D2 receptor hetero-oligomers.

DRD1 DRD5

1.61e-06326219171671
Pubmed

Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells.

DRD1 DRD5

1.61e-06326222710646
Pubmed

Activation of D1/D5 dopamine receptors protects neurons from synapse dysfunction induced by amyloid-beta oligomers.

DRD1 DRD5

1.61e-06326221115476
Pubmed

Dopamine D₁-like receptors regulate the α₁A-adrenergic receptor in human renal proximal tubule cells and D₁-like dopamine receptor knockout mice.

DRD1 DRD5

1.61e-06326225339698
Pubmed

G-protein coupled receptors Mc4r and Drd1a can serve as surrogate odorant receptors in mouse olfactory sensory neurons.

MC4R DRD1

1.61e-06326229407371
Pubmed

Aging-related dysregulation of dopamine and angiotensin receptor interaction.

DRD1 AGTR1

1.61e-06326224529758
Pubmed

Dopamine receptor genes and migraine with and without aura: an association study.

DRD1 DRD5

1.61e-06326212047334
Pubmed

Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on striatal interneurons.

DRD1 DRD5

1.61e-06326212867509
Pubmed

β2-adrenergic receptor Thr164Ile polymorphism, obesity, and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individuals.

MC4R ADRB2

3.22e-06426222466342
Pubmed

Low affinity binding of the classical D1 antagonist SCH23390 in rodent brain: potential interaction with A2A and D2-like receptors.

DRD1 DRD5

3.22e-06426216962565
Pubmed

Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients.

DRD1 DRD5

3.22e-06426220164562
Pubmed

Association study between the phenotype migraine without aura-panic disorder and dopaminergic receptor genes.

DRD1 DRD5

3.22e-06426212967601
Pubmed

Aging-related dysregulation in enteric dopamine and angiotensin system interactions: implications for gastrointestinal dysfunction in the elderly.

DRD1 AGTR1

3.22e-06426229541380
Pubmed

Dopamine genes and pathological gambling in discordant sib-pairs.

DRD1 DRD5

3.22e-06426217394052
Pubmed

Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells.

DRD1 DRD5

3.22e-06426225049074
Pubmed

Genes involved in the regulation of vascular homeostasis determine renal survival rate in patients with chronic glomerulonephritis.

ADRB2 AGTR1

3.22e-06426224727057
Pubmed

Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system.

DRD1 DRD5

3.22e-06426218403039
Pubmed

Dopamine receptors: from structure to function.

DRD1 DRD5

5.37e-0652629457173
Pubmed

Expression of apoptosis-related proteins and of mRNA for dopaminergic receptors in peripheral blood mononuclear cells from patients with Alzheimer disease.

BAX DRD5

5.37e-06526219266703
Pubmed

[Dopamine receptor signaling regulates human osteoclastogenesis].

DRD1 DRD5

5.37e-06526223445730
Pubmed

Evidence against dopamine D1/D2 receptor heteromers.

DRD1 DRD5

5.37e-06526225560761
Pubmed

Dopaminergic signaling in the cochlea: receptor expression patterns and deletion phenotypes.

DRD1 DRD5

5.37e-06526222219295
Pubmed

The central melanocortin system directly controls peripheral lipid metabolism.

MC4R ADRB2

5.37e-06526217885689
Pubmed

Single nucleotide polymorphisms in genes of circulatory homeostasis in surviving pediatric intensive care patients with meningococcal infection.

ADRB2 AGTR1

5.37e-06526218679149
Pubmed

The effects of spiritual intervention and changes in dopamine receptor gene expression in breast cancer patients.

DRD1 DRD5

5.37e-06526226597879
Pubmed

Impact of the dopamine receptor gene family on temperament traits in a population-based birth cohort.

DRD1 DRD5

5.37e-06526219105202
Pubmed

Neuron-specific age-related decreases in dopamine receptor subtype mRNAs.

DRD1 DRD5

5.37e-06526212509874
Pubmed

Dopamine receptor loss of function is not protective of rd1 rod photoreceptors in vivo.

DRD1 DRD5

5.37e-06526220038975
Pubmed

Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive.

DRD5 AGTR1

5.37e-06526212486173
Pubmed

Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain.

DRD1 DRD5

5.37e-06526220714340
Pubmed

Upregulation of renal D5 dopamine receptor ameliorates the hypertension in D3 dopamine receptor-deficient mice.

DRD1 DRD5

5.37e-06526223753418
Pubmed

Dopamine receptor mRNA and protein expression in the mouse corpus striatum and cerebral cortex during pre- and postnatal development.

DRD1 DRD5

5.37e-06526217509542
Pubmed

Molecular pharmacology and modeling of vasopressin receptors.

ADRB2 AGTR1

5.37e-06526212436935
Pubmed

Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice.

DRD1 DRD5

5.37e-06526218083900
Pubmed

Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors.

DRD1 DRD5 ADRB2

8.00e-06522638288218
Pubmed

Relation of beta(2)-adrenoceptor haplotype to risk of death and heart transplantation in patients with heart failure.

ADRB2 AGTR1

8.05e-06626217223428
Pubmed

Overexpression of insulin-like growth factor-1 attenuates the myocyte renin-angiotensin system in transgenic mice.

BAX AGTR1

8.05e-06626210205143
Pubmed

Noradrenergic signaling mediates cortical early tagging and storage of remote memory.

DRD1 ADRB2

8.05e-06626236494350
Pubmed

Rod vision is controlled by dopamine-dependent sensitization of rod bipolar cells by GABA.

DRD1 DRD5

8.05e-06626221982372
Pubmed

Retinal dopamine mediates multiple dimensions of light-adapted vision.

DRD1 DRD5

8.05e-06626222764243
Pubmed

Predominance of interaction among wild-type alleles of CYP11B2 in Himalayan natives associates with high-altitude adaptation.

ADRB2 AGTR1

8.05e-06626216893516
Pubmed

DISC1 regulates primary cilia that display specific dopamine receptors.

DRD1 DRD5

8.05e-06626220531939
Pubmed

Association study of 182 candidate genes in anorexia nervosa.

MC4R DRD1 DRD5 ADRB2

9.91e-0618226420468064
Pubmed

[Association analysis of the essential hypertension susceptibility genes in adolescents: Kangwha study].

ADRB2 AGTR1

1.13e-05726216615274
Pubmed

Angiotensin converting enzyme DD genotype is associated with hypertensive crisis.

ADRB2 AGTR1

1.13e-05726212394950
Pubmed

Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma.

MC4R ADRB2

1.13e-05726223312282
Pubmed

Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human.

MC4R ADRB2

1.50e-0582627949735
Pubmed

Two-stage case-control association study of dopamine-related genes and migraine.

DRD1 DRD5

1.93e-05926219772578
Pubmed

Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor: analysis of dopamine receptor expression, location, development, and function in wild-type and knock-out mice.

DRD1 DRD5

1.93e-05926216525059
Pubmed

Gene-load score of the renin-angiotensin-aldosterone system is associated with coronary heart disease in familial hypercholesterolaemia.

ADRB2 AGTR1

1.93e-05926218413308
Pubmed

Confirmation of quantitative trait loci for cocaine-induced activation in the AcB/BcA series of recombinant congenic strains.

DRD1 DRD5

1.93e-05926212777963
Pubmed

Leptin regulation of bone resorption by the sympathetic nervous system and CART.

MC4R ADRB2

2.41e-051026215724149
Pubmed

Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD).

DRD1 DRD5

2.41e-051026221083670
Pubmed

Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia.

DRD1 DRD5

2.94e-051126218855532
Pubmed

Impact of genomic polymorphism on arterial hypertension after aortic coarctation repair.

ADRB2 AGTR1

2.94e-051126220537417
Pubmed

Support for association between ADHD and two candidate genes: NET1 and DRD1.

DRD1 DRD5

2.94e-051126215717291
Pubmed

Genetic factors are relevant and independent determinants of antihypertensive drug effects in a multiracial population.

ADRB2 AGTR1

2.94e-051126219779464
Pubmed

Common genetic variation, residential proximity to traffic exposure, and left ventricular mass: the multi-ethnic study of atherosclerosis.

ADRB2 AGTR1

3.53e-051226220308035
Pubmed

Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder.

DRD1 ADRB2

4.17e-051326218937294
Pubmed

A multipoint genetic linkage map of mouse chromosome 18.

DRD1 ADRB2

4.86e-05142621354640
Pubmed

Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary.

BAX RSPO1

4.86e-051426224036309
Pubmed

A large-scale candidate gene association study of age at menarche and age at natural menopause.

MC4R DRD1 DRD5 ADRB2

4.98e-0527526420734064
Pubmed

Identification of G Protein-Coupled Receptors (GPCRs) in Primary Cilia and Their Possible Involvement in Body Weight Control.

DRD1 DRD5

5.61e-051526226053317
Pubmed

The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.

ADRB2 AGTR1

6.41e-051626215824464
Pubmed

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

DRD1 DRD5 ADRB2 AGTR1

6.98e-0530026419086053
Pubmed

Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.

BAX ADRB2 AGTR1

7.19e-0510826319956635
Pubmed

Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.

DRD1 DRD5

8.16e-05182628521822
Pubmed

Association study between candidate genes and obesity-related phenotypes using a sample of lumberjacks.

MC4R ADRB2

8.16e-051826219367093
Pubmed

Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.

MC4R ADRB2 PIK3C2G

9.12e-0511726318996102
Pubmed

A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP).

ADRB2 AGTR1

1.12e-042126215452121
Pubmed

Worldwide genetic variation in dopamine and serotonin pathway genes: implications for association studies.

DRD1 DRD5

1.12e-042126218270970
Pubmed

A common variant in DRD3 receptor is associated with autism spectrum disorder.

MC4R DRD1 DRD5

1.19e-0412826319058789
Pubmed

HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells.

BAX PIK3C2G

1.23e-042226211994280
Pubmed

Genetical genomic determinants of alcohol consumption in rats and humans.

DRD1 DRD5 ADRB2

1.25e-0413026319874574
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

MC4R CCR8 ADRB2 SLC39A8 AGTR1

1.48e-0469726528298427
Pubmed

Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.

BAX DRD5 ADRB2

1.58e-0414126318636124
InteractionDNAJC14 interactions

DRD1 ADRB2 AGTR1

3.18e-0550253int:DNAJC14
InteractionPTGER1 interactions

DRD1 ADRB2

6.61e-0510252int:PTGER1
InteractionJKAMP interactions

ADRB2 AGTR1

1.33e-0414252int:JKAMP
GeneFamilyDopamine receptors

DRD1 DRD5

1.41e-055222181
GeneFamilySolute carriers

SLC4A10 SLC25A32 SLC28A3 SLC16A14 SLC39A8

9.40e-05395225752
ToppCellCOVID_vent-Lymphocytic-T_cell-Gamma_Delta_T_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

SLC4A10 DRD5 SULT2B1 CRISPLD1

1.01e-06132264dbc0a332fd8f63ebdcf9716e45d7f46f26509349
ComputationalGenes in the cancer module 146.

CCR8 ADRB2 AGTR1

9.49e-05102103MODULE_146
ComputationalGenes in the cancer module 288.

CCR8 AGTR1

5.10e-0437102MODULE_288
Drug1,1-diphenylethylene

DRD1 DRD5 ADRB2

4.61e-087263CID000010740
DrugDO 710

DRD1 DRD5 ADRB2

1.58e-0710263CID003084985
DrugAC1L1CM5

DRD1 DRD5 ADRB2

2.17e-0711263CID000001961
DrugBulbokaprin

DRD1 DRD5 ADRB2

3.75e-0713263CID000009276
DrugA68930

DRD1 DRD5 ADRB2

4.77e-0714263CID000122324
Drugbenzimidazol-2-one

DRD1 DRD5 ADRB2

4.77e-0714263CID000162542
DrugA 86929

DRD1 DRD5 ADRB2

5.96e-0715263ctd:C095427
DrugHV723

DRD1 DRD5 ADRB2

5.96e-0715263CID003081094
Drugdelta H

DRD1 DRD5 ADRB2

7.33e-0716263CID000034771
Drugmorphine hydrochloride

MC4R BAX DRD1 CCR8 DRD5 ADRB2 AGTR1

8.35e-07481267CID000004253
DrugAMPT

DRD1 DRD5 ADRB2

1.07e-0618263CID000002112
Drugfenoldopam

DRD1 DRD5 ADRB2 AGTR1

1.16e-0670264CID000003340
Drugcolumbamine

DRD1 DRD5

1.25e-062262CID000072309
Drugdehydrocorybulbine

DRD1 DRD5

1.25e-062262CID005316439
Drugzelandopam

DRD1 DRD5

1.25e-062262CID003078104
DrugEXP985

ADRB2 AGTR1

1.25e-062262CID000132735
Drugtetrahydrocolumbamine

DRD1 DRD5

1.25e-062262CID000010220
DrugSB 200646A

MC4R DRD1 DRD5

1.27e-0619263CID000126769
DrugDAS-431

DRD1 DRD5 ADRB2

1.73e-0621263CID000166543
Drugpseudococaine

MC4R BAX DRD1 CCR8 DRD5 ADRB2 PIK3C2G

2.58e-06570267CID000002826
Drug5,6-dihydroxy-2-dimethylaminotetralin

DRD1 DRD5 ADRB2

2.63e-0624263CID000037032
Drugibopamine

DRD1 DRD5 ADRB2

2.63e-0624263CID000068555
Drugepinine

DRD1 DRD5 ADRB2

2.63e-0624263CID000004382
Drugtardan

DRD1 DRD5 ADRB2

3.38e-0626263CID000002729
Drugpiperoxan

DRD1 DRD5 ADRB2

3.38e-0626263CID000006040
DrugAC1LR3WA

DRD1 DRD5

3.76e-063262CID001361946
DrugBerupipam

DRD1 DRD5

3.76e-063262CID000066002
Drugcarphenazine

DRD1 DRD5

3.76e-063262CID000018104
DrugU-99363E

DRD1 DRD5

3.76e-063262CID000133107
DrugCarphenazine

DRD1 DRD5

3.76e-063262DB01038
Drugecopipam

DRD1 DRD5

3.76e-063262ctd:C058081
Drugroxindole

DRD1 DRD5 ADRB2

4.25e-0628263CID000219050
Drugdopexamine

DRD1 DRD5 ADRB2

6.41e-0632263CID000055483
DrugDB921

DRD1 DRD5 ADRB2

7.05e-0633263CID005327049
Drugdimethocaine

DRD1 DRD5

7.51e-064262CID000007177
DrugMK-458

DRD1 DRD5

7.51e-064262CID000057532
DrugSCH 40853

DRD1 DRD5

7.51e-064262CID003035575
DrugDK-118

DRD1 DRD5

7.51e-064262CID000145953
DrugU 101958

DRD1 DRD5

7.51e-064262CID005311492
Drugtransdihydrolisuride

DRD1 DRD5 ADRB2

7.73e-0634263CID000005406
Drugfluspirilene

DRD1 DRD5 ADRB2

7.73e-0634263CID000003396
Drug1H-3

DRD1 DRD5 SULT2B1

1.09e-0538263CID000043849
DrugAPAs

MC4R DRD5 AGTR1

1.18e-0539263CID000004649
DrugSCH 24518

DRD1 DRD5

1.25e-055262CID000146265
DrugDH97

DRD1 DRD5

1.25e-055262CID003467177
DrugAMMTC

DRD1 DRD5

1.25e-055262CID005311004
Drugtilozepine

DRD1 DRD5

1.25e-055262CID000172286
Drug2-di-n-propylaminoindan

DRD1 DRD5

1.25e-055262CID000130402
Drugmezilamine

DRD1 DRD5

1.25e-055262CID000068678
DrugC9H11N3O2

DRD1 DRD5

1.25e-055262CID000123703
DrugNNC-687

DRD1 DRD5

1.25e-055262CID000164252
DrugSKF 77434

DRD1 DRD5

1.25e-055262CID000001241
Drugproterguride

DRD1 DRD5

1.25e-055262CID000071999
DrugNO 756

DRD1 DRD5

1.25e-055262CID000129967
DrugLevodopa

DRD1 DRD5

1.25e-055262DB01235
DrugSKF 82957

DRD1 DRD5

1.25e-055262CID000130844
DrugSKF85174

DRD1 DRD5

1.25e-055262CID000132435
Drugcorydaline

DRD1 DRD5

1.25e-055262CID000101301
Drugl-CSL

DRD1 DRD5

1.25e-055262CID006918538
Drug3-iodobenzamide

DRD1 DRD5

1.25e-055262CID000202425
Drugdihydrexidine

DRD1 DRD5

1.25e-055262ctd:C061532
Drugdazopride

DRD1 DRD5

1.25e-055262CID000054801
DrugFenoldopam

DRD1 DRD5

1.25e-055262DB00800
Drugazapride

DRD1 DRD5

1.25e-055262CID003036441
Drugpiquindone

DRD1 DRD5

1.25e-055262CID000121903
DrugA 68930

DRD1 DRD5

1.25e-055262ctd:C065380
DrugNSC95090

DRD1 DRD5 ADRB2

1.27e-0540263CID000003251
Drugolanzapine

DRD1 DRD5 ADRB2 SULT2B1

1.33e-05129264CID000004585
DrugDAR-0100A

DRD1 DRD5 ADRB2

1.37e-0541263CID000060759
Drugspiroxatrine

DRD1 DRD5 ADRB2

1.47e-0542263CID000005268
Drugnisoxetine

DRD1 DRD5 ADRB2

1.47e-0542263CID000004500
DrugNSD-1015

DRD1 DRD5 ADRB2

1.58e-0543263CID000001663
Drug2'-ISP

DRD1 DRD5

1.88e-056262CID000128389
DrugRotigotine

DRD1 DRD5

1.88e-056262DB05271
Drugpyrazole-3

DRD1 DRD5

1.88e-056262CID000354929
DrugZuclopenthixol

DRD1 DRD5

1.88e-056262DB01624
Drugpergolide sulfone

DRD1 DRD5

1.88e-056262CID000155750
Drugpergolide sulfoxide

DRD1 DRD5

1.88e-056262CID000155749
DrugSch-38548

DRD1 DRD5

1.88e-056262CID000130519
DrugA66359

DRD1 DRD5

1.88e-056262CID000173657
DrugCI-943

DRD1 DRD5

1.88e-056262CID000146009
DrugAC1L1JFX

DRD1 DRD5

1.88e-056262CID000005023
Drugpropylbutyldopamine

DRD1 DRD5

1.88e-056262CID000156067
DrugN,N-dimethyldopamine

DRD1 DRD5

1.88e-056262CID000152427
Drugoxiperomide

DRD1 DRD5

1.88e-056262CID000068634
DrugAC1L1I8U

DRD1 DRD5

1.88e-056262CID000055036
DrugLON-954

DRD1 DRD5

1.88e-056262CID006441097
Drugp-bromospiperone

DRD1 DRD5

1.88e-056262CID000156386
DrugMDO-NPA

DRD1 DRD5

1.88e-056262CID000133642
DrugLY293284

DRD1 DRD5

1.88e-056262CID000132345
Drug7-hydroxyamoxapine

DRD1 DRD5

1.88e-056262CID000162242
DrugBAM-1110

DRD1 DRD5

1.88e-056262CID003064755
Drug5,6-ADTN

DRD1 DRD5

1.88e-056262CID000037630
Drugethylamine hydrochloride

DRD1 DRD5

1.88e-056262CID000011198
DrugAC1MI81B

DRD1 DRD5

1.88e-056262CID003039938
DrugHW-165

DRD1 DRD5

1.88e-056262CID000125677
DrugGBR 13098

DRD1 DRD5

1.88e-056262CID000132672
Drugflupenthixol decanoate

DRD1 DRD5

1.88e-056262CID006434100
DrugPhenethylamines

DRD1 DRD5

1.88e-056262ctd:D010627
Drugabeorphine

DRD1 DRD5

1.88e-056262CID000133849
Diseasenicotine dependence symptom count, depressive symptom measurement

ADRB2 RSPO1 AGMO

3.93e-0575263EFO_0007006, EFO_0009262
Diseasesevere acute respiratory syndrome, COVID-19

SLC4A10 NMBR PIK3C2G WDFY4 AGMO

3.95e-05447265EFO_0000694, MONDO_0100096
Diseaselongitudinal BMI measurement

MC4R SLC28A3 PIK3C2G

5.14e-0582263EFO_0005937
DiseaseAlzheimer's disease (is_marker_for)

BAX DRD1 DRD5 AGTR1

7.23e-05257264DOID:10652 (is_marker_for)
DiseaseHuntington's disease (biomarker_via_orthology)

BAX DRD1

8.89e-0516262DOID:12858 (biomarker_via_orthology)
Diseasehypertension (is_implicated_in)

DRD1 ADRB2 AGTR1

1.63e-04121263DOID:10763 (is_implicated_in)
Diseasedilated cardiomyopathy (biomarker_via_orthology)

BAX AGTR1

1.71e-0422262DOID:12930 (biomarker_via_orthology)
Diseasedepressive disorder (implicated_via_orthology)

DRD1 DRD5

1.71e-0422262DOID:1596 (implicated_via_orthology)
Diseaseanti-basement membrane glomerulonephritis (biomarker_via_orthology)

BAX AGTR1

3.20e-0430262DOID:4780 (biomarker_via_orthology)
Diseaseobese body mass index status

MC4R SLC39A8

3.88e-0433262EFO_0007041
DiseaseParkinson disease, disease progression measurement

SLC28A3 CRISPLD1

5.42e-0439262EFO_0008336, MONDO_0005180
Diseasecongestive heart failure (implicated_via_orthology)

ADRB2 AGTR1

5.99e-0441262DOID:6000 (implicated_via_orthology)
Diseasemetabolic syndrome

MC4R SLC39A8 AGMO

7.11e-04200263EFO_0000195
Diseasedepressive disorder (biomarker_via_orthology)

BAX DRD1

9.64e-0452262DOID:1596 (biomarker_via_orthology)
Diseasehypertension (biomarker_via_orthology)

BAX ADRB2 AGTR1

1.03e-03227263DOID:10763 (biomarker_via_orthology)
DiseaseInsulin Sensitivity

MC4R ADRB2

1.28e-0360262C0920563
Diseasemigraine disorder, type 2 diabetes mellitus

SLC4A10 SLC28A3

1.28e-0360262MONDO_0005148, MONDO_0005277
DiseaseInsulin Resistance

MC4R ADRB2

1.28e-0360262C0021655
Diseaseacute kidney failure (biomarker_via_orthology)

BAX ADRB2

1.32e-0361262DOID:3021 (biomarker_via_orthology)
DiseaseHDL cholesterol change measurement, physical activity

MC4R SLC39A8

1.37e-0362262EFO_0003940, EFO_0007805
DiseaseAutistic Disorder

DRD1 ADRB2 WDFY4

1.53e-03261263C0004352
DiseaseParkinson's disease (is_marker_for)

DRD5 AGTR1

1.59e-0367262DOID:14330 (is_marker_for)
DiseaseManic Disorder

DRD1 DRD5

1.79e-0371262C0024713
Diseaseneuroimaging measurement, brain volume measurement

SLC4A10 SLC39A8 AGMO

1.99e-03286263EFO_0004346, EFO_0006930
DiseaseDepressive disorder

MC4R DRD1 DRD5

2.05e-03289263C0011581
DiseaseManic

DRD1 DRD5

2.15e-0378262C0338831
DiseaseDepression, Bipolar

DRD1 DRD5

2.21e-0379262C0005587
Diseasedilated cardiomyopathy (implicated_via_orthology)

ADRB2 AGTR1

2.26e-0380262DOID:12930 (implicated_via_orthology)
DiseaseIschemic stroke

MC4R PIK3C2G AGMO

2.83e-03324263HP_0002140

Protein segments in the cluster

PeptideGeneStartEntry
RVIILMVWIVSGLTS

ADRB2

151

P07550
ICIAFWGVRSMKQLT

AGMO

426

Q6ZNB7
TMLVAKVTCIIIWLL

AGTR1

141

P30556
LKTLSVIMGVFVCCW

DRD1

271

P21728
KTLSVIMGVFVCCWL

DRD5

296

P21918
MHIWKVSRQCLLTLI

PIK3C2G

396

O75747
CITNPLWVTKTRLML

SLC25A32

136

Q9H2D1
ALLRTCVKAMGIWVV

NMBR

156

P28336
SKRVCVLMITGSWII

OR2L8

136

Q8NGY9
AAIWVTILCMARLKT

PGAP6

616

Q9HCN3
TIRMGTTLCLAVWLT

CCR8

146

P51685
MKCTAREWLRVTTVL

CRISPLD1

1

Q9H336
CTKVPELIRTIMGWT

BAX

126

Q07812
MTVKRVGIIISCIWA

MC4R

161

P32245
IGRVSLAAKSLCMWV

DNAH2

3186

Q9P225
WAMVTCNLSSKIIRV

NRROS

616

Q86YC3
SGTTWMIEIICLILK

SULT2B1

71

O00204
NMCALRILKTVSWLT

SLC16A14

276

Q7RTX9
MRLGLCVVALVLSWT

RSPO1

1

Q2MKA7
IIRKVGWIMLVTTGS

SLC28A3

311

Q9HAS3
WRMLLIVVSVCTATG

CNEP1R1

31

Q8N9A8
WKIGLMCFLSIIITT

CLEC2A

26

Q6UVW9
MSCLGLLWIIKVSRA

SLC4A10

991

Q6U841
CVASVVSVKGRLMWL

SFMBT2

426

Q5VUG0
VVCVWELSMTKGRPR

WDFY4

2956

Q6ZS81
VGRCKLWMIITSIFL

TTMP

61

Q5BVD1
KLSEIGTIAWMITLC

SLC39A8

296

Q9C0K1