Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC9A2 KCNA7 KCNC3 TRPV6 CACNA1G GRIN3B SLC4A4 SLC4A5 KCNH3

5.39e-05465749GO:0046873
GeneOntologyMolecularFunctionsodium:bicarbonate symporter activity

SLC4A4 SLC4A5

2.01e-046742GO:0008510
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC9A2 KCNA7 KCNC3 TRPV6 CACNA1G GRIN3B SLC4A4 SLC4A5 KCNH3

5.02e-04627749GO:0022890
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

KCNA7 KCNC3 CACNA1G GRIN3B KCNH3

5.77e-04182745GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

KCNA7 KCNC3 CACNA1G GRIN3B KCNH3

6.06e-04184745GO:0022832
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC9A2 KCNA7 KCNC3 TMC8 TRPV6 CACNA1G GRIN3B SLC4A4 SLC4A5 KCNH3

6.64e-047937410GO:0015075
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC9A2 KCNA7 KCNC3 TRPV6 CACNA1G GRIN3B SLC4A4 SLC4A5 KCNH3

7.57e-04664749GO:0008324
GeneOntologyMolecularFunctionmonoatomic cation:bicarbonate symporter activity

SLC4A4 SLC4A5

1.03e-0313742GO:0140410
GeneOntologyMolecularFunctiongated channel activity

KCNA7 KCNC3 TMC8 CACNA1G GRIN3B KCNH3

1.49e-03334746GO:0022836
GeneOntologyMolecularFunctionmonoatomic ion channel activity

KCNA7 KCNC3 TMC8 TRPV6 CACNA1G GRIN3B KCNH3

1.55e-03459747GO:0005216
GeneOntologyMolecularFunctionmonoatomic cation channel activity

KCNA7 KCNC3 TRPV6 CACNA1G GRIN3B KCNH3

1.71e-03343746GO:0005261
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC9A2 KCNA7 KCNC3 TRPV6 CACNA1G GRIN3B SLC4A4 SLC4A5 KCNH3

1.90e-03758749GO:0015318
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

KCNA7 KCNC3 CACNA1G KCNH3

2.46e-03152744GO:0022843
GeneOntologyMolecularFunctionextracellular matrix binding

FBLN2 PLEKHA2 ITGA2B

2.52e-0373743GO:0050840
GeneOntologyMolecularFunctionchannel activity

KCNA7 KCNC3 TMC8 TRPV6 CACNA1G GRIN3B KCNH3

3.29e-03525747GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

KCNA7 KCNC3 TMC8 TRPV6 CACNA1G GRIN3B KCNH3

3.32e-03526747GO:0022803
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

SLC9A2 KCNA7 KCNC3 KCNH3

3.45e-03167744GO:0015079
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC9A2 CACNA1G SLC4A4 SLC4A5

3.75e-03171744GO:0015081
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC9A2 KCNA7 KCNC3 TMC8 PEX13 TRPV6 CACNA1G GRIN3B SLC4A4 SLC4A5 KCNH3

3.97e-0311807411GO:0022857
DomainIon_trans_dom

KCNA7 KCNC3 TRPV6 CACNA1G KCNH3

8.93e-05114745IPR005821
DomainIon_trans

KCNA7 KCNC3 TRPV6 CACNA1G KCNH3

8.93e-05114745PF00520
DomainNa/HCO3_transpt

SLC4A4 SLC4A5

1.54e-045742IPR003024
DomainBand3_cytoplasmic_dom

SLC4A4 SLC4A5

5.48e-049742IPR013769
DomainBand_3_cyto

SLC4A4 SLC4A5

5.48e-049742PF07565
Domain-

SLC4A4 SLC4A5

5.48e-0497423.40.1100.10
DomainHCO3_cotransp

SLC4A4 SLC4A5

6.83e-0410742PF00955
DomainHCO3_transpt_C

SLC4A4 SLC4A5

6.83e-0410742IPR011531
DomainPTrfase/Anion_transptr

SLC4A4 SLC4A5

6.83e-0410742IPR016152
DomainHCO3_transpt_euk

SLC4A4 SLC4A5

6.83e-0410742IPR003020
DomainBTB_2

KCNA7 KCNC3 KCTD8

1.21e-0353743PF02214
DomainT1-type_BTB

KCNA7 KCNC3 KCTD8

1.21e-0353743IPR003131
DomainChannel_four-helix_dom

KCNA7 KCNC3 CACNA1G

1.50e-0357743IPR027359
Domain-

KCNA7 KCNC3 CACNA1G

1.50e-03577431.20.120.350
DomainZinc_finger_PHD-type_CS

KDM5B PHF3 CHD4

2.19e-0365743IPR019786
DomainPHD

KDM5B PHF3 CHD4

3.29e-0375743PF00628
DomainSH3_9

PEX13 ARHGEF6 ARHGAP33

3.67e-0378743PF14604
DomainZnf_PHD-finger

KDM5B PHF3 CHD4

3.81e-0379743IPR019787
DomainJmjC

KDM5B JMJD6

4.04e-0324742PF02373
DomainK_chnl_volt-dep_Kv

KCNA7 KCNC3

5.10e-0327742IPR003968
DomainPHD

KDM5B PHF3 CHD4

5.31e-0389743SM00249
DomainZnf_PHD

KDM5B PHF3 CHD4

5.65e-0391743IPR001965
DomainZF_PHD_2

KDM5B PHF3 CHD4

6.37e-0395743PS50016
DomainZF_PHD_1

KDM5B PHF3 CHD4

6.55e-0396743PS01359
Domainig

NPHS1 CNTN4 AGER LAG3

6.86e-03190744PF00047
DomainImmunoglobulin

NPHS1 CNTN4 AGER LAG3

6.86e-03190744IPR013151
DomainJMJC

KDM5B JMJD6

7.11e-0332742PS51184
DomainJmjC_dom

KDM5B JMJD6

7.11e-0332742IPR003347
DomainJmjC

KDM5B JMJD6

7.55e-0333742SM00558
DomainVG_K_chnl

KCNA7 KCNC3

7.55e-0333742IPR028325
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

STK4 MLXIPL KDM5B KCNA7 TRIP6 PHF3 CNKSR3 KCTD8 PLEKHA2 LARP1B CBL

3.45e-06861781136931259
Pubmed

Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins.

CBL SH2B2

4.97e-06278215737992
Pubmed

c-Cbl regulates αPix-mediated cell migration and invasion.

CBL ARHGEF6

4.97e-06278225450678
Pubmed

αPIX Is a Trafficking Regulator that Balances Recycling and Degradation of the Epidermal Growth Factor Receptor.

CBL ARHGEF6

1.49e-05378226177020
Pubmed

The APS adapter protein couples the insulin receptor to the phosphorylation of c-Cbl and facilitates ligand-stimulated ubiquitination of the insulin receptor.

CBL SH2B2

1.49e-05378210854852
Pubmed

Differential subcellular localization regulates c-Cbl E3 ligase activity upon Notch3 protein in T-cell leukemia.

CBL NOTCH3

1.49e-05378219966856
Pubmed

RAGE regulates BACE1 and Abeta generation via NFAT1 activation in Alzheimer's disease animal model.

NFATC2 AGER

2.97e-05478219332646
Pubmed

A fluorescence correlation spectroscopy-based assay for fragment screening of slowly inhibiting protein-peptide interaction inhibitors.

CBL SH2B2

2.97e-05478220298671
Pubmed

APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis.

CBL SH2B2

2.97e-0547829989826
Pubmed

The association between the SH2-containing inositol polyphosphate 5-Phosphatase 2 (SHIP2) and the adaptor protein APS has an impact on biochemical properties of both partners.

CBL SH2B2

2.97e-05478217620296
Pubmed

The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.

CBL ARHGEF6

2.97e-05478212935897
Pubmed

Primary and essential role of the adaptor protein APS for recruitment of both c-Cbl and its associated protein CAP in insulin signaling.

CBL SH2B2

2.97e-05478215031295
Pubmed

APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes.

CBL SH2B2

7.40e-05678211997497
Pubmed

APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl.

CBL SH2B2

7.40e-05678210374881
Pubmed

Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3.

AGER NOTCH3

7.40e-0567827835890
Pubmed

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.

KCNA7 KCNC3 KCNH3

1.01e-044078316382104
Pubmed

Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation.

CBL SH2B2

1.04e-0477829233773
Pubmed

The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport.

CBL SH2B2

1.04e-04778212842890
Pubmed

Nerve growth factor stimulates the concentration of TrkA within lipid rafts and extracellular signal-regulated kinase activation through c-Cbl-associated protein.

CBL SH2B2

1.04e-04778217548467
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

MYO9B GLYR1 SOHLH1 PLEKHA2 CHD4 SLC4A5

1.04e-0433278637433992
Pubmed

A human MAP kinase interactome.

MAP1A CSN2 RBM33 MCM3AP SLC4A4 CBL ARHGAP33

1.12e-0448678720936779
Pubmed

Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement.

ITGA2B CBL

1.38e-04878211964172
Pubmed

Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.

KCNA7 KCNC3

1.77e-0497829488722
Pubmed

Familial pure proximal renal tubular acidosis--a clinical and genetic study.

SLC9A2 SLC4A4

1.77e-04978217881426
Pubmed

Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates.

CBL SH2B2

2.21e-041078218273061
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

KCNA7 KCNC3 CACNA1G KCNH3

2.77e-0413978416985003
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

SLC9A2 CAD TRIP6 GLYR1 LAG3 CACNA1G CHD4 WDR77

2.90e-0475478835906200
Pubmed

CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity.

CHD4 ITGA2B

3.23e-041278227140400
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

MLXIPL CAD NFATC2 TRIP6 PHF3 CHD4 WDR77

3.39e-0458378729844126
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

PCF11 RBM33 MCM3AP NOTCH3

7.34e-0418078435198878
Pubmed

SARS-CoV-2 ORF8 Protein Induces Endoplasmic Reticulum Stress-like Responses and Facilitates Virus Replication by Triggering Calnexin: an Unbiased Study.

CAD WDR77

7.42e-041878236877072
Pubmed

The contribution of de novo coding mutations to autism spectrum disorder.

KDM5B PHF3

7.42e-041878225363768
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

PTPRN2 AGER PEX13 EXTL1 NOTCH3

8.82e-0432978517474147
Pubmed

Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics.

NFATC2 CBL

9.19e-042078231591574
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

CAD NFATC2 PHF3 CHD4 ARHGEF6

1.48e-0337078522922362
Pubmed

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.

AGER CBL WDR77

1.63e-0310378321706016
Pubmed

Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.

CHFR RNF25 CBL

1.73e-0310578322493164
Pubmed

High glucose mediates the ChREBP/p300 transcriptional complex to activate proapoptotic genes Puma and BAX and contributes to intervertebral disc degeneration.

MLXIPL CHD4

1.94e-032978234461288
Pubmed

RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.

CAD CHD4

1.94e-032978236800290
Pubmed

The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein.

GLYR1 GLIS2

1.94e-032978212438443
Pubmed

Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling.

STK4 AGER

1.94e-032978230651296
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

PCF11 TRIP6 RBM33 IRGQ WDR77

2.06e-0339978535987950
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

CAD MAP1A TRIP6 RBM33 MYO9B MCM3AP

2.09e-0358878638580884
InteractionGRB2 interactions

MLXIPL CAD MAP1A PTPRN2 CSN2 RBM33 GGN AGER PLEKHA2 ITGA2B CBL SH2B2 WDR77

6.66e-068067413int:GRB2
CytobandEnsembl 112 genes in cytogenetic band chr19q13

NPHS1 SELENOV KCNA7 KCNC3 GGN PRR19 IRGQ DBP ARHGAP33

1.91e-041192789chr19q13
Cytoband2p13

CD207 SLC4A5

7.04e-04237822p13
CytobandEnsembl 112 genes in cytogenetic band chr2p13

CD207 C2orf78 SLC4A5

1.79e-03140783chr2p13
Cytoband7q22

TRIP6 SH2B2

1.93e-03387827q22
GeneFamilyPotassium voltage-gated channels

KCNA7 KCNC3 KCNH3

2.30e-0440543274
GeneFamilyPHD finger proteins

KDM5B PHF3 CHD4

2.46e-039054388
GeneFamilyImmunoglobulin like domain containing

NPHS1 CNTN4 AGER LAG3

2.62e-03193544594
GeneFamilyC2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors

AGER CD207

2.93e-03275421253
CoexpressionAtlasFacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#1

STK4 SELENOV MLXIPL MAP1A RSPH4A CARMIL3 LAG3 RNF25 ZKSCAN2 IRGQ ARHGEF6

1.28e-056147711Facebase_RNAseq_e10.5_Medial Nasal Eminence_2500_K1
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_2500_k-means-cluster#3

SELENOV MLXIPL MAP1A RSPH4A CARMIL3 LAG3 ZKSCAN2 IRGQ ARHGEF6

3.40e-05447779Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_2500_K3
DrugCarbamazepine [298-46-4]; Down 200; 17uM; PC3; HT_HG-U133A

SLC9A2 JMJD6 PHF3 GLYR1 MCM3AP CBL NOTCH3

4.80e-061957875093_DN
DiseaseChild Development Disorders, Specific

CNTN4 CHD4 SLC4A4 CBL

9.19e-0729764C0085997
DiseaseChild Development Deviations

CNTN4 CHD4 SLC4A4 CBL

9.19e-0729764C0085996
DiseaseDevelopmental Disabilities

CNTN4 CHD4 SLC4A4 CBL

1.06e-0630764C0008073
Diseaseanemia (implicated_via_orthology)

SLC4A4 SLC4A5

6.73e-0415762DOID:2355 (implicated_via_orthology)
Diseasecorpus callosum central volume measurement

SLC9A2 BTG3

2.37e-0328762EFO_0010296
Diseaselevel of Sphingomyelin (d42:2) in blood serum

MLXIPL SLC4A4

2.54e-0329762OBA_2045183

Protein segments in the cluster

PeptideGeneStartEntry
AGAIPRWLRPFIPKP

CYP27C1

271

Q4G0S4
PRGPLEPPQIIKPWS

ARHGEF6

576

Q15052
SLQPRPWRKPTVPEP

C2orf78

851

A6NCI8
MWRPKRGPPLVVIPP

FAM78B

246

Q5VT40
TRKPPPSQPPGNIIW

CNTN4

896

Q8IWV2
WMKDGVPLPLPPSPV

AGER

271

Q15109
PRLPLQDQWRAPPPP

RBM33

441

Q96EV2
PRPLLAPAAPQKWPS

PTPRN2

276

Q92932
GLRLPPMPWNVPPDL

KCNH3

806

Q9ULD8
VPPTWPKPLVPAIPI

NFATC2

371

Q13469
VLFPPGPPVIEWPGL

NPHS1

236

O60500
GKFVPVNWEPPQPLP

LY6G5C

41

Q5SRR4
RPSKKAPVQWIPPPD

KCTD8

391

Q6ZWB6
PRTQLPTWPPEFKPL

JMJD6

241

Q6NYC1
PATWMRPPREPAQPP

MICAL3

1491

Q7RTP6
DIPPWVPKDRPLPPA

MAP1A

1841

P78559
PAPPPPAQPRRWKAG

FAM43B

306

Q6ZT52
PQMDLPPLGAPWLPV

MCM3AP

1671

O60318
PALAPWPPKPVAVPR

CARMIL3

1271

Q8ND23
WPPKPVAVPRGRQPP

CARMIL3

1276

Q8ND23
TIQAPPWPAVLPRPT

FBLN2

241

P98095
PQLPPVAPRPLRPNW

PDZD7

736

Q9H5P4
LGRYPPWPGKIVNPP

GLYR1

16

Q49A26
VAVPLDWARLPPPAP

NOTCH3

2166

Q9UM47
ICKVRPPPDWQPPFA

KDM5B

61

Q9UGL1
WVAPVKPLQPGAEVP

LAG3

16

P18627
WKPPPPLPSERQPAD

GGN

171

Q86UU5
PGWVVIPPGSVLLKP

GLIS2

506

Q9BZE0
PRPGPLKPSLGPWSL

POM121L12

231

Q8N7R1
LLKVPVPGLGPWPRV

PRR35

301

P0CG20
LDPAWPIKPLPPNVN

PCF11

141

O94913
PPVPRLPQKQRAPWG

ARHGAP33

1201

O14559
RWPAKEVGPRPQIPA

LINC00472

41

Q9H8W2
EGKQSPPPQPWGRLL

CHFR

6

Q96EP1
EVPELPPPLWAPPGK

KCNA7

436

Q96RP8
WGTIPKLPPPGRSPL

CACNA1G

2111

O43497
LALPPQPLWSVPQPK

CSN2

161

P05814
QPLWSVPQPKVLPIP

CSN2

166

P05814
IPKPPWLGFLGPILR

HEPHL1

91

Q6MZM0
PPRHPFQPWVNPKVE

KIAA1210

946

Q9ULL0
PGPVPAPGLLAPLLW

DBP

91

Q10586
LGDSWLPRPIPKVPV

CBL

586

P22681
LIWKWGQPPSPTPVP

CHD4

506

Q14839
PTPFPAPERPNVVLW

IRGQ

261

Q8WZA9
EPEKWPIPGPPPRSV

LARP1B

291

Q659C4
PPPLVPPAAREWNLP

WDR77

6

Q9BQA1
IGWKPLAPIFPPLPK

PCARE

796

A6NGG8
PPPQGAQVWPKLRVV

GRIN3B

406

O60391
EPGRPWVKLPPVIPA

RSPH4A

436

Q5TD94
PWTPVPQAGEKLLPP

PLEKHA2

356

Q9HB19
KPVLWHSPRPLGPPQ

VARS2

826

Q5ST30
VPWPPGRSLPKAVRP

SOHLH1

226

Q5JUK2
PPGLEPWNRVRIPKA

NEPRO

6

Q6NW34
PPPPKPWETRRIPGA

PEX13

6

Q92968
IPRLVPPPAPAWIPT

SELENOV

81

P59797
PPVNPLKVDWGLPIP

ITGA2B

861

P08514
LLAPKQAEGRWPPPE

MLXIPL

201

Q9NP71
ALIWVGPPGQPPLKL

EXTL1

421

Q92935
KPYRPIPVTWVPPPG

BTG3

221

Q14201
LWPREPPPKSGPSLV

CD207

21

Q9UJ71
NLRWKPPLVQTSPPP

CNK3/IPCEF1

306

G9CGD6
NLRWKPPLVQTSPPP

CNKSR3

306

Q6P9H4
GSAWQPPPLPVLRKP

ZNF503-AS2

106

A6NEH8
PPPLPVLRKPAWPGS

ZNF503-AS2

111

A6NEH8
WLPPKQPEPARAPQG

TRIP6

6

Q15654
VLLPLVWLRPPDPGP

TMC8

131

Q8IU68
LKWKRPPENEAPPVP

PIGT

336

Q969N2
LTEGIPPKPPPRLVW

SLC9A2

781

Q9UBY0
PPKPPPRLVWRASEP

SLC9A2

786

Q9UBY0
LKSIWLVATPPPPRP

PRR19

286

A6NJB7
MLDPPKPSRGPWRQP

RNF25

336

Q96BH1
VWPRPQAPKEPALHP

TRPV6

26

Q9H1D0
PPKPLRFLPGVLIGW

PHF3

1436

Q92576
PPGEWDPNIRIEPPK

SLC4A5

401

Q9BY07
AAPVPVPVPVPDWRQ

SH2B2

11

O14492
KWPQGAVPQLPPSAP

CAD

1811

P27708
PLPKNARPSPWVPAL

ZKSCAN2

191

Q63HK3
VKEPHPLPLVPRPWF

ZDHHC19

11

Q8WVZ1
WAVPPAPPQPGRVKE

PRR29

31

P0C7W0
PPGEWDPAIRIEPPK

SLC4A4

381

Q9Y6R1
IPTNPPPTFRKPELW

STK4

236

Q13043
RAVLIPPKGPWPPAQ

nan

111

Q96M66
PPKGPWPPAQGLAMR

nan

116

Q96M66
IRKATGAPPLPPQDW

KCNC3

721

Q14003
KLPPGLPSHLPRWAP

MYO9B

2071

Q13459