Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	L-amino acid transmembrane transporter activity	SLC7A5 SLC7A6 SLC7A11 SLC7A10	2.85e-04	71	89	4	GO:0015179
GeneOntologyMolecularFunction	3'-5' RNA helicase activity	DHX38 YTHDC2	2.91e-04	6	89	2	GO:0034458
GeneOntologyMolecularFunction	polysaccharide binding	CLEC18A CLEC18B CLEC18C	3.52e-04	31	89	3	GO:0030247
GeneOntologyMolecularFunction	RNA helicase activity	DHX36 DDX52 DHX38 YTHDC2	4.09e-04	78	89	4	GO:0003724
GeneOntologyMolecularFunction	ATP-dependent activity, acting on RNA	DHX36 DDX52 DHX38 YTHDC2	4.50e-04	80	89	4	GO:0008186
GeneOntologyBiologicalProcess	neutral amino acid transport	LLGL2 SLC7A5 SLC7A6 SLC7A11 SLC7A10	5.72e-06	60	88	5	GO:0015804
GeneOntologyBiologicalProcess	L-leucine transport	LLGL2 SLC7A5 SLC7A6	8.81e-06	10	88	3	GO:0015820
GeneOntologyBiologicalProcess	branched-chain amino acid transport	LLGL2 SLC7A5 SLC7A6	2.64e-05	14	88	3	GO:0015803
GeneOntologyBiologicalProcess	L-amino acid transport	LLGL2 SLC7A5 SLC7A6 SLC7A11 SLC7A10	9.95e-05	108	88	5	GO:0015807
Domain	AA_permease_2	SLC7A5 SLC7A6 SLC7A11 SLC7A10	2.90e-07	13	86	4	PF13520
Domain	AA/rel_permease1	SLC7A5 SLC7A6 SLC7A11 SLC7A10	2.90e-07	13	86	4	IPR002293
Domain	AA-permease/SLC12A_dom	SLC7A5 SLC7A6 SLC7A11 SLC7A10	2.88e-06	22	86	4	IPR004841
Domain	AA_permease	SLC7A5 SLC7A6 SLC7A11 SLC7A10	2.88e-06	22	86	4	PF00324
Domain	Aquaporin_12	AQP12A AQP12B	2.10e-05	2	86	2	IPR023265
Domain	-	CLEC18A CLEC18B CLEC18C	4.12e-05	15	86	3	3.40.33.10
Domain	CAP	CLEC18A CLEC18B CLEC18C	4.12e-05	15	86	3	PF00188
Domain	CAP_domain	CLEC18A CLEC18B CLEC18C	4.12e-05	15	86	3	IPR014044
Domain	SCP	CLEC18A CLEC18B CLEC18C	4.12e-05	15	86	3	SM00198
Domain	Allrgn_V5/Tpx1	CLEC18A CLEC18B CLEC18C	4.12e-05	15	86	3	IPR001283
Domain	DUF1605	DHX36 DHX38 YTHDC2	6.12e-05	17	86	3	IPR011709
Domain	OB_NTP_bind	DHX36 DHX38 YTHDC2	6.12e-05	17	86	3	PF07717
Domain	Aquaporin_11/12	AQP12A AQP12B	6.27e-05	3	86	2	IPR016697
Domain	L_AA_transporter	SLC7A5 SLC7A11	6.27e-05	3	86	2	IPR004760
Domain	HA2	DHX36 DHX38 YTHDC2	7.32e-05	18	86	3	SM00847
Domain	HA2	DHX36 DHX38 YTHDC2	7.32e-05	18	86	3	PF04408
Domain	Helicase-assoc_dom	DHX36 DHX38 YTHDC2	7.32e-05	18	86	3	IPR007502
Domain	HNOB_dom_associated	GUCY2F GUCY2D	3.11e-04	6	86	2	IPR011645
Domain	HNOBA	GUCY2F GUCY2D	3.11e-04	6	86	2	PF07701
Domain	DEAD/DEAH_box_helicase_dom	DHX36 DDX52 DHX38 YTHDC2	3.58e-04	73	86	4	IPR011545
Domain	DEAD	DHX36 DDX52 DHX38 YTHDC2	3.58e-04	73	86	4	PF00270
Domain	DEAH_ATP_HELICASE	DHX36 DHX38 YTHDC2	7.08e-04	38	86	3	PS00690
Domain	C-type_lectin_CS	CLEC18A CLEC18B CLEC18C	1.02e-03	43	86	3	IPR018378
Domain	-	CLEC18A COL18A1 CLEC18B CLEC18C	1.05e-03	97	86	4	3.10.100.10
Domain	C-type_lectin-like/link	CLEC18A COL18A1 CLEC18B CLEC18C	1.13e-03	99	86	4	IPR016186
Domain	CTDL_fold	CLEC18A COL18A1 CLEC18B CLEC18C	1.51e-03	107	86	4	IPR016187
Domain	Helicase_C	DHX36 DDX52 DHX38 YTHDC2	1.51e-03	107	86	4	PF00271
Domain	HELICc	DHX36 DDX52 DHX38 YTHDC2	1.51e-03	107	86	4	SM00490
Domain	Helicase_C	DHX36 DDX52 DHX38 YTHDC2	1.56e-03	108	86	4	IPR001650
Domain	HELICASE_CTER	DHX36 DDX52 DHX38 YTHDC2	1.61e-03	109	86	4	PS51194
Domain	HELICASE_ATP_BIND_1	DHX36 DDX52 DHX38 YTHDC2	1.61e-03	109	86	4	PS51192
Domain	DEXDc	DHX36 DDX52 DHX38 YTHDC2	1.61e-03	109	86	4	SM00487
Domain	Helicase_ATP-bd	DHX36 DDX52 DHX38 YTHDC2	1.67e-03	110	86	4	IPR014001
Domain	MIP	AQP12A AQP12B	1.84e-03	14	86	2	PS00221
Domain	MIP	AQP12A AQP12B	1.84e-03	14	86	2	PF00230
Domain	MIP	AQP12A AQP12B	2.12e-03	15	86	2	IPR000425
Domain	-	AQP12A AQP12B	2.12e-03	15	86	2	1.20.1080.10
Domain	Aquaporin-like	AQP12A AQP12B	2.12e-03	15	86	2	IPR023271
Domain	A/G_cyclase_CS	GUCY2F GUCY2D	2.72e-03	17	86	2	IPR018297
Domain	Nucleotide_cyclase	GUCY2F GUCY2D	3.06e-03	18	86	2	IPR029787
Domain	-	GUCY2F GUCY2D	3.06e-03	18	86	2	3.30.70.1230
Domain	Sm	LSM11 NAA38	3.41e-03	19	86	2	SM00651
Domain	GUANYLATE_CYCLASE_1	GUCY2F GUCY2D	3.41e-03	19	86	2	PS00452
Domain	LSM	LSM11 NAA38	3.41e-03	19	86	2	PF01423
Domain	Guanylate_cyc	GUCY2F GUCY2D	3.41e-03	19	86	2	PF00211
Domain	GUANYLATE_CYCLASE_2	GUCY2F GUCY2D	3.41e-03	19	86	2	PS50125
Domain	A/G_cyclase	GUCY2F GUCY2D	3.41e-03	19	86	2	IPR001054
Domain	CYCc	GUCY2F GUCY2D	3.41e-03	19	86	2	SM00044
Domain	LSM_dom_euk/arc	LSM11 NAA38	3.41e-03	19	86	2	IPR001163
Domain	LSM_dom	LSM11 NAA38	4.56e-03	22	86	2	IPR010920
Pathway	REACTOME_BASIGIN_INTERACTIONS	SLC7A5 SLC7A6 SLC7A11 SLC7A10	2.76e-06	24	59	4	MM17215
Pathway	REACTOME_BASIGIN_INTERACTIONS	SLC7A5 SLC7A6 SLC7A11 SLC7A10	3.28e-06	25	59	4	M4974
Pathway	REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE	SLC7A5 SLC7A6 SLC7A11 SLC7A10	9.12e-06	32	59	4	MM14957
Pathway	REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE	SLC7A5 SLC7A6 SLC7A11 SLC7A10	1.03e-05	33	59	4	M188
Pathway	REACTOME_VISUAL_PHOTOTRANSDUCTION	GUCY2F GUCY2D RBP3 STRA6 CNGB1	4.02e-05	92	59	5	MM14881
Pathway	REACTOME_VISUAL_PHOTOTRANSDUCTION	GUCY2F GUCY2D RBP3 STRA6 CNGB1	6.00e-05	100	59	5	M27158
Pathway	REACTOME_THE_PHOTOTRANSDUCTION_CASCADE	GUCY2F GUCY2D CNGB1	2.88e-04	31	59	3	MM14896
Pathway	WP_MRNA_PROTEIN_AND_METABOLITE_INDUCATION_PATHWAY_BY_CYCLOSPORIN_A	SLC7A5 SLC7A11	3.57e-04	7	59	2	M42540
Pathway	REACTOME_THE_PHOTOTRANSDUCTION_CASCADE	GUCY2F GUCY2D CNGB1	3.80e-04	34	59	3	M27183
Pathway	REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES	SLC7A5 SLC7A6 SLC7A11 SLC7A10	1.07e-03	108	59	4	M823
Pathway	REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES	SLC7A5 SLC7A6 SLC7A11 SLC7A10	1.11e-03	109	59	4	MM15074
Pathway	REACTOME_SENSORY_PERCEPTION	GUCY2F GUCY2D RBP3 STRA6 CNGB1	1.17e-03	190	59	5	MM15687
Pathway	REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS	AQP12A AQP12B	1.30e-03	13	59	2	MM15095
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	COL18A1 WIZ FLYWCH1 ZNF592 MED16 CLK3 DDX52 PIEZO1 POLR2B DHX38 RALGAPB INTS1 SLC7A5 YTHDC2 LSM11 CLP1 SERPINH1 NDUFS2 SDAD1 SLC30A6	1.81e-09	1497	92	20	31527615
Pubmed	Metabolic activation-related CD147-CD98 complex.	SLC7A5 SLC7A6 SLC7A11 SLC7A10	5.72e-09	9	92	4	15901826
Pubmed	Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.	CLEC18A CLEC18B CLEC18C	1.79e-08	3	92	3	26170455
Pubmed	The C-type lectin-like domain superfamily.	CLEC18A CLEC18B CLEC18C	1.79e-08	3	92	3	16336259
Pubmed	Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.	CLEC18A CLEC18B CLEC18C	1.79e-08	3	92	3	33603190
Pubmed	The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation.	CLEC18A CLEC18B CLEC18C	7.15e-08	4	92	3	16709836
Pubmed	Amino acid transport across mammalian intestinal and renal epithelia.	SLC7A5 SLC7A6 SLC7A11 SLC7A10	1.37e-06	31	92	4	18195088
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	DHX36 WIZ GSE1 PEG10 POLR2B DHX38 INTS1 YARS2	3.58e-06	341	92	8	32971831
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	GDPD5 SPHK2 RAPGEF6 LLGL2 WIZ MROH1 OFD1 ZNF592 PIEZO1 SCN5A INTS1 SLC7A5 HR	6.85e-06	1105	92	13	35748872
Pubmed	The production of the endostatin precursor collagen XVIII in head and neck carcinomas is modulated by CBP2/Hsp47.	COL18A1 SERPINH1	6.92e-06	2	92	2	12174873
Pubmed	The involvement of L-type amino acid transporters in theanine transport.	SLC7A5 SLC7A6	6.92e-06	2	92	2	23221699
Pubmed	Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2.	GUCY2F GUCY2D	6.92e-06	2	92	2	7777544
Pubmed	Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells.	AQP12A AQP12B	6.92e-06	2	92	2	15809071
Pubmed	Amino acid transporters as emerging therapeutic targets in cancer.	SLC7A5 SLC7A11	6.92e-06	2	92	2	34091991
Pubmed	GSE1 predicts poor survival outcome in gastric cancer patients by SLC7A5 enhancement of tumor growth and metastasis.	GSE1 SLC7A5	6.92e-06	2	92	2	29367342
Pubmed	The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors.	GUCY2F GUCY2D	6.92e-06	2	92	2	17255100
Pubmed	Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis.	AQP12A AQP12B	6.92e-06	2	92	2	19726746
Pubmed	Genetic analysis of the aquaporin water channels AQP12A and AQP12B in patients with chronic pancreatitis.	AQP12A AQP12B	6.92e-06	2	92	2	36167651
Pubmed	Co-expression effect of LLGL2 and SLC7A5 to predict prognosis in ERα-positive breast cancer.	LLGL2 SLC7A5	6.92e-06	2	92	2	36192404
Pubmed	LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer.	LLGL2 SLC7A5	6.92e-06	2	92	2	30996345
Pubmed	Exploration of human ORFeome: high-throughput preparation of ORF clones and efficient characterization of their protein products.	PIEZO1 MYNN OR51J1	7.96e-06	15	92	3	18316326
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DHX36 RAPGEF6 LLGL2 GSE1 DHX38 RALGAPB YTHDC2 PPIP5K2 SORL1 HR	8.84e-06	650	92	10	38777146
Pubmed	Genetic architecture of human thinness compared to severe obesity.	PKHD1 PRDM6	2.07e-05	3	92	2	30677029
Pubmed	Retinal degeneration-3 protein attenuates photoreceptor degeneration in transgenic mice expressing dominant mutation of human retinal guanylyl cyclase.	GUCY2F GUCY2D	2.07e-05	3	92	2	34537244
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	ZNF592 MED16 POLR2B DHX38 YTHDC2 CLP1 SERPINH1 SDAD1	2.27e-05	440	92	8	34244565
Pubmed	Streamlined analysis schema for high-throughput identification of endogenous protein complexes.	ZNF592 MED16 POLR2B INTS1	3.89e-05	71	92	4	20133760
Pubmed	RD3, the protein associated with Leber congenital amaurosis type 12, is required for guanylate cyclase trafficking in photoreceptor cells.	GUCY2F GUCY2D	4.14e-05	4	92	2	21078983
Pubmed	Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression.	SLC7A5 SLC7A6	4.14e-05	4	92	2	22007000
Pubmed	Retinal guanylyl cyclase isozyme 1 is the preferential in vivo target for constitutively active GCAP1 mutants causing congenital degeneration of photoreceptors.	GUCY2F GUCY2D	4.14e-05	4	92	2	22623665
Pubmed	The kinase homology domain of retinal guanylyl cyclases 1 and 2 specifies the affinity and cooperativity of interaction with guanylyl cyclase activating protein-2.	GUCY2F GUCY2D	4.14e-05	4	92	2	9698373
Pubmed	Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family.	SLC7A5 SLC7A6	4.14e-05	4	92	2	9878049
Pubmed	Ornithine transport via cationic amino acid transporter-1 is involved in ornithine cytotoxicity in retinal pigment epithelial cells.	SLC7A5 SLC7A6	4.14e-05	4	92	2	17197568
Pubmed	Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains.	SLC7A5 SLC7A6	4.14e-05	4	92	2	11311135
Pubmed	Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance.	SLC7A5 SLC7A6	4.14e-05	4	92	2	9829974
Pubmed	Nonsyndromic Retinitis Pigmentosa Overview	OFD1 DHX38 RBP3 CNGB1	6.53e-05	81	92	4	20301590
Pubmed	A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome.	GUCY2F GUCY2D RBP3 CNGB1	6.53e-05	81	92	4	16110338
Pubmed	Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice.	GUCY2F GUCY2D	6.89e-05	5	92	2	23082185
Pubmed	Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors.	GUCY2F GUCY2D	6.89e-05	5	92	2	21598940
Pubmed	Retinal guanylyl cyclase activation by calcium sensor proteins mediates photoreceptor degeneration in an rd3 mouse model of congenital human blindness.	GUCY2F GUCY2D	6.89e-05	5	92	2	31346032
Pubmed	Functional Study and Mapping Sites for Interaction with the Target Enzyme in Retinal Degeneration 3 (RD3) Protein.	GUCY2F GUCY2D	6.89e-05	5	92	2	27471269
Pubmed	Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.	ZNF592 PIEZO1 DHX38 SLC7A6	7.18e-05	83	92	4	9039502
Pubmed	Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling.	CLEC18A CLEC18B CLEC18C	1.30e-04	37	92	3	22432025
Pubmed	Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina.	GUCY2F GUCY2D	1.44e-04	7	92	2	8838319
Pubmed	A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3' End Processing Complex.	POLR2B CLP1	1.44e-04	7	92	2	31980388
Pubmed	Growth differentiation factor 1-induced tumour plasticity provides a therapeutic window for immunotherapy in hepatocellular carcinoma.	AFP GDF1	1.44e-04	7	92	2	34880251
Pubmed	An atlas of genetic influences on human blood metabolites.	ADHFE1 HEATR4 UGT1A6 SLC7A5 SLC7A6	1.54e-04	190	92	5	24816252
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	OFD1 USP25 KIF5C SDCBP2 MYCBPAP SLC7A11	1.56e-04	302	92	6	30561431
Pubmed	The Type 3 Deiodinase Is a Critical Modulator of Thyroid Hormone Sensitivity in the Fetal Brain.	AFP SORL1 HR	2.35e-04	45	92	3	34248495
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	PKHD1 YTHDC2 SERPINH1 SDAD1 SORL1	2.35e-04	208	92	5	33230847
Pubmed	The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.	SLC7A6 SLC7A11 SLC7A10 NPAS1 SORL1	2.57e-04	212	92	5	19521566
Pubmed	A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.	MED16 POLR2B POLR2M	2.67e-04	47	92	3	15175163
Pubmed	NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes.	POLR2B NFYC	3.07e-04	10	92	2	15601870
Pubmed	Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice.	ANK1 AFP	3.07e-04	10	92	2	12543979
Pubmed	Human transcription factor protein interaction networks.	DHX36 WIZ GSE1 OFD1 NKX2-4 ZNF592 DDX52 PEG10 NFYC CLP1 SDAD1 SORL1	3.85e-04	1429	92	12	35140242
Pubmed	Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.	MED16 POLR2B INTS1	4.03e-04	54	92	3	16239144
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	OFD1 PEG10 DHX38 INTS1 YTHDC2	4.70e-04	242	92	5	34011540
Pubmed	Multiple loci influencing hippocampal degeneration identified by genome scan.	COL18A1 VPS13B	5.30e-04	13	92	2	22745009
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DHX36 WIZ MED16 CLK3 POLR2B INTS1 PPIP5K2 CLP1 NDUFS2 SDAD1	5.85e-04	1082	92	10	38697112
Pubmed	Identification of novel inhibitors of human immunodeficiency virus type 1 replication by in silico screening targeting cyclin T1/Tat interaction.	POLR2B POLR2M	6.17e-04	14	92	2	23274668
Pubmed	RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.	DHX36 POLR2B YTHDC2 NDUFS2	6.58e-04	148	92	4	35676246
Pubmed	The HIV-1 Vpr co-activator induces a conformational change in TFIIB.	POLR2B POLR2M	7.11e-04	15	92	2	10359081
Pubmed	Cooperative interaction between HIV-1 regulatory proteins Tat and Vpr modulates transcription of the viral genome.	POLR2B POLR2M	7.11e-04	15	92	2	10931842
Pubmed	Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal Gland Cells.	AQP12A AQP12B	7.11e-04	15	92	2	34540996
Pubmed	HIV-1 reverse transcription.	APOBEC3G POLR2M	7.11e-04	15	92	2	23028129
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	WIZ ANK1 GSE1 ZNF592 INTS1 PKHD1 ZC2HC1C NDUFS2	7.56e-04	736	92	8	29676528
Pubmed	Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.	SCN5A PRDM6	8.11e-04	16	92	2	25035420
Pubmed	Human immunodeficiency virus type 1 (HIV-1) Vpr enhances expression from unintegrated HIV-1 DNA.	POLR2B POLR2M	8.11e-04	16	92	2	12634356
Pubmed	HIV-1 Vpr binding to HIV-1 LTR C/EBP cis-acting elements and adjacent regions is sequence-specific.	POLR2B POLR2M	8.11e-04	16	92	2	12642036
Pubmed	Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.	ANK1 PIEZO1	9.17e-04	17	92	2	24647736
Pubmed	Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance.	AQP12A AQP12B	9.17e-04	17	92	2	26847765
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	DHX36 SPHK2 WIZ MED16 POLR2B	9.21e-04	281	92	5	24163370
Pubmed	Changes in thyroid status during perinatal development of MCT8-deficient male mice.	SLC7A5 HR	1.03e-03	18	92	2	23696569
Pubmed	TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis.	NWD1 SDAD1	1.03e-03	18	92	2	32924931
Pubmed	The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation.	POLR2B POLR2M	1.03e-03	18	92	2	23087374
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	WIZ MED16 PEG10 POLR2B	1.03e-03	167	92	4	20362541
Pubmed	Expression patterns of the aquaporin gene family during renal development: influence of genetic variability.	AQP12A AQP12B	1.15e-03	19	92	2	19367412
Pubmed	Transcription factor TFIIH components enhance the GR coactivator activity but not the cell cycle-arresting activity of the human immunodeficiency virus type-1 protein Vpr.	POLR2B POLR2M	1.15e-03	19	92	2	12379213
Pubmed	Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites.	GDF1 HR	1.27e-03	20	92	2	16679559
Pubmed	Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1.	OFD1 PKHD1	1.27e-03	20	92	2	17251353
Pubmed	Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice.	SLC7A5 SLC7A11	1.27e-03	20	92	2	33665549
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	GSE1 ZNF592 POLR2B INTS1	1.28e-03	177	92	4	26206133
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	DHX36 CLK3 DDX52 PEG10 POLR2B DHX38 YTHDC2 YARS2	1.36e-03	807	92	8	22681889
Pubmed	Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease.	OFD1 PKHD1	1.41e-03	21	92	2	27591083
Pubmed	A mouse knockout library for secreted and transmembrane proteins.	CLEC18A CLEC18B INTS1 CLEC18C SLC7A5 STRA6	1.42e-03	460	92	6	20562862
Pubmed	The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord.	GUCY2F GUCY2D	1.69e-03	23	92	2	17954614
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	DHX36 CLK3 DDX52 POLR2B DHX38 SLC7A5 YTHDC2 SERPINH1 NDUFS2 SDAD1	1.81e-03	1257	92	10	36526897
Pubmed	ATRX proximal protein associations boast roles beyond histone deposition.	WIZ FLYWCH1 ZNF592	1.84e-03	91	92	3	34780483
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	DHX36 WIZ ZNF592 DDX52 PEG10 DHX38 SLC7A5 SDAD1	1.84e-03	847	92	8	35850772
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	WIZ GSE1 FLYWCH1 DDX52 NFYC PRDM6 GAA SORL1	1.98e-03	857	92	8	25609649
Pubmed	The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.	POLR2B INTS1	2.00e-03	25	92	2	34004147
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	RAPGEF6 OFD1 CLK3 RALGAPB KIF5C PPIP5K2 SERPINH1 ZNRF2	2.04e-03	861	92	8	36931259
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	NWD1 ANK1 ZNF592 POLR2B YTHDC2 SDAD1	2.09e-03	497	92	6	36774506
Pubmed	Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity.	POLR2B INTS1	2.16e-03	26	92	2	33298525
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	COL18A1 NKX2-4 DDX52 PEG10 YTHDC2	2.38e-03	349	92	5	25665578
Pubmed	Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.	OFD1 HEATR4	2.50e-03	28	92	2	20736409
Pubmed	Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.	SPHK2 ZDHHC24 TOP6BL	2.55e-03	102	92	3	21926972
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	DHX36 COL18A1 ANK1 GSE1 DDX52 POLR2B DHX38 INTS1 PPIP5K2 SERPINH1	2.55e-03	1318	92	10	30463901
GeneFamily	Guanylate cyclase receptors	GUCY2F GUCY2D	2.25e-04	7	60	2	343
GeneFamily	C-type lectin domain family	CLEC18A CLEC18B CLEC18C	5.08e-04	47	60	3	494
GeneFamily	Aquaporins	AQP12A AQP12B	9.61e-04	14	60	2	305
GeneFamily	DEAH-box helicases	DHX36 DHX38	1.26e-03	16	60	2	500
GeneFamily	RNA polymerase subunits	POLR2B POLR2M	4.15e-03	29	60	2	726
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AFP RBP3 PKHD1 PRDM6 VWA5B1 STAR	2.84e-06	193	91	6	315840bc48899f3a36d57b19197509de19716e3d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CPAMD8 TOP6BL SDCBP2 VWA5B1 LRRC9	5.64e-06	124	91	5	1fec6663cea40017438ead397b3bf8b3cdb67e58
ToppCell	frontal_cortex-Non-neuronal-astrocyte-Astro\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADHFE1 NWD1 SERPINH1 SLC7A11 SLC7A10	1.77e-05	157	91	5	0551442ae14685d8fe5729e3960c6324b1e05e4d
ToppCell	frontal_cortex-Non-neuronal-astrocyte\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADHFE1 NWD1 SERPINH1 SLC7A11 SLC7A10	1.77e-05	157	91	5	803af734d7f775d294391e2b84e472a732e18cef
ToppCell	frontal_cortex-Non-neuronal-astrocyte-Astro-Astro_Aqp4\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADHFE1 NWD1 SERPINH1 SLC7A11 SLC7A10	1.77e-05	157	91	5	9aa5304a9704da6dd4eda7d6940494b00e38b2e8
ToppCell	droplet-Bladder-BLADDER-1m-Epithelial-basal_bladder_epithelial_cell_(Krt5+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AFP PKHD1 SLC7A11 PCDH1 SORL1	2.25e-05	165	91	5	936581de8fcd097401707438b9bbe89dd4e3e247
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GSE1 CLK3 GUCY2D SLC7A5 SORL1	2.52e-05	169	91	5	4e1322cc5e1733e9fb19e08f739a30206f43cea8
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SPHK2 ADHFE1 TOP6BL VPS13B SORL1	3.32e-05	179	91	5	db76edd368eeca05a2a5d407c3eb2f535ade0ce3
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANK1 PEG10 NPIPB11 SCN5A NPAS1	3.41e-05	180	91	5	b6efdb4d319ef6f87f559acd974e5a71b06a2322
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADHFE1 NWD1 SLC7A11 SLC7A10 LRRC9	3.99e-05	186	91	5	ac7a84b11b4550c4ac01eab370dc8ab88e4fb72b
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	COL18A1 LLGL2 PKHD1 KIF5C SORL1	4.41e-05	190	91	5	625c08a0e5227efc46daa512fd579c3938ff76c7
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CPAMD8 PIEZO1 PKHD1 TOP6BL VWA5B1	4.87e-05	194	91	5	04bfc555743f7d8821439d05ae442d15e9886c59
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MIR7-3HG CLEC18B SCN5A KIF5C CNGB1	4.87e-05	194	91	5	15224fb3e7ca5bd1fb8c41f8275842f737014095
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CPAMD8 PIEZO1 PKHD1 TOP6BL VWA5B1	4.87e-05	194	91	5	69bff17df4a760ccf081cf52ff04af02c14f448d
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Macroglial-Astrocyte\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	ZDHHC24 CLEC18C SERPINH1 SLC7A11 SLC7A10	5.12e-05	196	91	5	55a10faafcbe075eefdfcd7cff25ded040c23538
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Macroglial\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	ZDHHC24 CLEC18C SERPINH1 SLC7A11 SLC7A10	5.12e-05	196	91	5	8025ec8aee8455c7b0261aa4a0caacebd2f50634
ToppCell	Transverse-Macrophage-LYVE1_Macrophage\|Macrophage / Region, Cell class and subclass	RAPGEF6 NEURL2 WIZ TOP6BL SDCBP2	5.50e-05	199	91	5	fd75dccb37d96448edf72b7d042b06833d4ead24
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL18A1 UGT1A6 PIEZO1 PKHD1 TOP6BL	5.50e-05	199	91	5	3cd6383c50ce342fe5c175e2e50784d634a90e80
Disease	Retinitis Pigmentosa	OFD1 GUCY2D DHX38 RBP3 CNGB1	1.53e-05	104	88	5	C0035334
Disease	congenital stationary night blindness (is_implicated_in)	GUCY2D TRPV3	5.26e-05	4	88	2	DOID:0050534 (is_implicated_in)
Disease	Cataract	COL18A1 CPAMD8 INTS1	1.85e-04	37	88	3	C0086543
Disease	retinitis pigmentosa (is_implicated_in)	OFD1 GUCY2D CNGB1	2.52e-04	41	88	3	DOID:10584 (is_implicated_in)
Disease	Ciliopathies	OFD1 GUCY2D PKHD1 GDF1	3.35e-04	110	88	4	C4277690
Disease	Disorder of eye	OFD1 GUCY2D RBP3 STRA6 CNGB1	4.41e-04	212	88	5	C0015397
Disease	Retinal Detachment	COL18A1 CPAMD8	4.75e-04	11	88	2	C0035305
Disease	exercise test	COL18A1 POLR2M	1.61e-03	20	88	2	EFO_0004328
Disease	colorectal adenocarcinoma (is_marker_for)	SLC7A5 STRA6	2.94e-03	27	88	2	DOID:0050861 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
IPVMLHGRELLASAP	DDX52	196	Q9Y2R4
MVLAVLLHQGRLPHL	AQP12A	231	Q8IXF9
MQPIHEVLRHTSLGP	C8A	461	P07357
REGHLPSLLAMIHVR	SLC7A10	346	Q9NS82
PSLLAMIHVRHCTPI	SLC7A10	351	Q9NS82
HIMLGEILRHSMDPP	APOBEC3G	186	Q9HC16
TPLHVASFMGHLPIV	ANK1	406	P16157
RHLSRLMVGPHAAVP	CT47B1	146	P0C2W7
PLHPSAMHLHLSGVR	GSE1	291	Q14687
KILGPIPSHMIHRTR	CLK3	536	P49761
MVLAVLLHQGRLPHL	AQP12B	231	A6NM10
ITDMHPGVLKTHRLP	NWD1	231	Q149M9
HELMHPVLSGELQPR	OFD1	46	O75665
AELPLHGHMIVFRLS	NPAS1	296	Q99742
NLPPIMHSLEVLHLG	LRRC9	1196	Q6ZRR7
LQLGMHSLHLHPELP	MIR7-3HG	81	Q8N6C7
APEREHLASMIHLTP	NKX2-4	216	Q9H2Z4
TRMPLHEGSPLGELH	LSM11	146	P83369
MHRAPVVGILVLDGH	LLGL2	771	Q6P1M3
VAHPLLLLRHLPMIA	INTS1	1871	Q8N201
RHMPEVPVRIRIGLH	GUCY2D	966	Q02846
VMRRHCHPPDLGGLE	FLYWCH1	561	Q4VC44
GHHELPPVLHTTMLR	ERN2	361	Q76MJ5
GPPALNHAVLRALMH	GDF1	311	P27539
LGHERIHMAFAPVTP	HR	771	O43593
PMIGLSLVHRFGEHL	OR51G1	256	Q8NGK1
PMIGLSIVHRLGHRV	OR51J1	256	Q9H342
LILGPPRMEHLRHSP	PCDH1	16	Q08174
DVRLRTPLLHPLVMG	COL18A1	256	P39060
TLPLALPLGTEDHHM	MYNN	561	Q9NPC7
LPLGTEDHHMLLPVT	MYNN	566	Q9NPC7
SPHLQVMLQIHLPGR	PEG10	346	Q86TG7
EGHLPSILSMIHPQL	SLC7A5	356	Q01650
IGHRGAPMLAPEHTL	GDPD5	231	Q8WTR4
MEELLRRLHPGTLPH	MROH1	126	Q8NDA8
LTSVLMIPHAGGHPL	OC90	6	Q02509
RSMVHRLAIDGLHLP	NEURL2	261	Q9BR09
LETHRELHAPLPGMT	NFYC	396	Q13952
PQHPAAHGVLRLVME	NDUFS2	86	O75306
MGHPLEVGLALRHLL	MED16	461	Q9Y2X0
PMHGPLHSLRRLVGT	PRDM6	211	Q9NQX0
GGRFHPQPMIISRHL	NPIPB11	756	E5RHQ5
VHLARLPVEPHIGKM	DHX36	691	Q9H2U1
HLAVTPSMVPLGRLL	CPAMD8	546	Q8IZJ3
HMPEVPVRIRIGLHS	GUCY2F	971	P51841
TVREAPRPLIHHPCM	HEATR4	156	Q86WZ0
MGVRHPPCSHRLLAV	GAA	1	P10253
PRVLGLAMVPGHHIV	NAA38	96	Q9BRA0
DDITAARLLPLHHMP	POLR2M	286	P0CAP2
ARLLPLHHMPTQLLS	POLR2M	291	P0CAP2
IGHLCIRHEMTPVNP	AFP	481	P02771
GLIDPLHTLHMPARV	ADHFE1	221	Q8IWW8
VAIIPHMLSGLLNPH	OR10J3	76	Q5JRS4
KMIPDSRLPPRHLHV	SORL1	1926	Q92673
HCRHSLAIMPIPGTL	RAPGEF6	711	Q8TEU7
HCSRIHPVLGHPVML	TOP6BL	191	Q8N6T0
HDPQLMGIIPRIAHD	KIF5C	101	O60282
HIMQLHVKEPERRGP	YARS2	331	Q9Y2Z4
LRLGSPDIHIMAPLI	IQCA1L	546	A6NCM1
SHLLRPVMLEHPPDT	SCN5A	616	Q14524
SLIILMPHHVEPLER	SERPINH1	266	P50454
MPHHVEPLERLEKLL	SERPINH1	271	P50454
IINPHAIPSRMTIGH	POLR2B	966	P30876
KREMLPGALHGELHP	WIZ	1186	O95785
MAPGPIELRAHAILV	PKHD1	1976	P08F94
SHHLVPPEIIQSLLM	SDAD1	361	Q9NVU7
LPPVLLHHTMDHSIP	SDCBP2	276	Q9H190
AIHLGQMDLSLLPPR	STRA6	541	Q9BX79
KLVPVTPGRDMVHHL	CLP1	351	Q92989
MLHPETSPGRGHLLA	CLEC18A	1	A5D8T8
MLHPETSPGRGHLLA	CLEC18B	1	Q6UXF7
MLHPETSPGRGHLLA	CLEC18C	1	Q8NCF0
HRLEMALPQPVLHGK	CNGB1	261	Q14028
LPEILSMIHVRKHTP	SLC7A11	351	Q9UPY5
LVIGSLPAHLSPHMF	ZNRF2	141	Q8NHG8
TEHLIMDLRHNPGGP	RBP3	471	P10745
MAHSPLHRSVSDLPL	SPHK2	411	Q9NRA0
IRAEHGPTCMVLHPL	STAR	216	P49675
PRPSLLESHISLMHG	ZNF592	1056	Q92610
LPMHPAPRHITEEEL	USP25	531	Q9UHP3
QRGLMEPITHIRKPH	MYCBPAP	291	Q8TBZ2
HLMVHNLVPPFLDGR	DHX38	406	Q92620
PAPLHSRDLHSMIVA	RALGAPB	821	Q86X10
RAHTPLHMAALLLLP	ZDHHC24	166	Q6UX98
RLASHLPVGVMLPHN	ZC2HC1C	6	Q53FD0
GSREGHLPDLLSMIH	SLC7A6	346	Q92536
HLADLPVEPHLGKMV	YTHDC2	831	Q9H6S0
HHVIPMPLLKGTDDL	SLC30A6	356	Q6NXT4
LFIMRSHLPDPIIIH	VPS13B	2846	Q7Z7G8
EEAIPHPLALTHKMG	TRPV3	466	Q8NET8
PIDMTISHLPLIHIL	VN1R17P	46	Q8TDU5
MFGHLSPVRIPHLRG	nan	76	Q5PR19
PREASPLHSLGHLIM	PIEZO1	406	Q92508
MVSEPIHIHRKSPLP	PPIP5K2	951	O43314
VEFVMRHKGAPHLRP	UGT1A6	461	P19224
HRLIVEGLLMDVPQH	ZNF619	106	Q8N2I2
LIHPSEPHMPHVLIE	VWA5B1	276	Q5TIE3