Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	coumarin 7-hydroxylase activity	CYP2A6 CYP2A7 CYP2A13	3.06e-09	3	30	3	GO:0008389
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP2A6 CYP2A7 CYP2A13	6.06e-06	24	30	3	GO:0008392
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP2A6 CYP2A7 CYP2A13	8.74e-06	27	30	3	GO:0008391
GeneOntologyMolecularFunction	steroid hydroxylase activity	CYP2A6 CYP2A7 CYP2A13	1.77e-05	34	30	3	GO:0008395
GeneOntologyMolecularFunction	aromatase activity	CYP2A6 CYP2A7 CYP2A13	1.94e-05	35	30	3	GO:0070330
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2A6 CYP2A7 CYP2A13	5.38e-05	49	30	3	GO:0016712
GeneOntologyMolecularFunction	heme binding	CYP2A6 CYP2A7 CYP2A13 STC2	7.98e-05	154	30	4	GO:0020037
GeneOntologyMolecularFunction	tetrapyrrole binding	CYP2A6 CYP2A7 CYP2A13 STC2	1.02e-04	164	30	4	GO:0046906
GeneOntologyMolecularFunction	monooxygenase activity	CYP2A6 CYP2A7 CYP2A13	6.75e-04	115	30	3	GO:0004497
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	CHD3 BTAF1	1.41e-03	37	30	2	GO:0140658
GeneOntologyMolecularFunction	helicase activity	CHD3 BTAF1 DICER1	1.69e-03	158	30	3	GO:0004386
GeneOntologyMolecularFunction	iron ion binding	CYP2A6 CYP2A7 CYP2A13	1.94e-03	166	30	3	GO:0005506
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	CYP2A6 CYP2A7 CYP2A13	3.02e-03	194	30	3	GO:0016705
GeneOntologyMolecularFunction	chromatin binding	TSPY4 TSPY9 CHD3 MTA1 ANKRD2	4.52e-03	739	30	5	GO:0003682
GeneOntologyMolecularFunction	RNA endonuclease activity	SLFN14 DICER1	6.26e-03	79	30	2	GO:0004521
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	CHD3 BTAF1 DICER1	6.98e-03	262	30	3	GO:0140097
GeneOntologyMolecularFunction	histone binding	TSPY4 TSPY9 CHD3	7.20e-03	265	30	3	GO:0042393
GeneOntologyBiologicalProcess	phenylpropanoid metabolic process	CYP2A6 CYP2A7 CYP2A13	2.98e-07	10	29	3	GO:0009698
GeneOntologyBiologicalProcess	coumarin metabolic process	CYP2A6 CYP2A7 CYP2A13	2.98e-07	10	29	3	GO:0009804
GeneOntologyBiologicalProcess	epoxygenase P450 pathway	CYP2A6 CYP2A7 CYP2A13	3.78e-06	22	29	3	GO:0019373
GeneOntologyBiologicalProcess	gonadal mesoderm development	TSPY4 TSPY9	6.83e-05	9	29	2	GO:0007506
GeneOntologyBiologicalProcess	secondary metabolic process	CYP2A6 CYP2A7 CYP2A13	1.13e-04	67	29	3	GO:0019748
GeneOntologyBiologicalProcess	arachidonate metabolic process	CYP2A6 CYP2A7 CYP2A13	1.18e-04	68	29	3	GO:0019369
GeneOntologyBiologicalProcess	protein localization to early endosome	MKLN1 ROCK2	2.26e-04	16	29	2	GO:1902946
GeneOntologyBiologicalProcess	regulation of endothelial cell development	ROCK2 DICER1	3.57e-04	20	29	2	GO:1901550
GeneOntologyBiologicalProcess	regulation of establishment of endothelial barrier	ROCK2 DICER1	3.57e-04	20	29	2	GO:1903140
GeneOntologyBiologicalProcess	regulation of stem cell differentiation	CHD3 MTA1 DICER1	3.58e-04	99	29	3	GO:2000736
GeneOntologyBiologicalProcess	chromatin remodeling	TSPY4 TSPY9 CHD3 BTAF1 MTA1 DICER1	4.93e-04	741	29	6	GO:0006338
GeneOntologyBiologicalProcess	cell-matrix adhesion	MKLN1 ROCK2 ITGAL DICER1	5.27e-04	270	29	4	GO:0007160
GeneOntologyCellularComponent	NuRD complex	CHD3 MTA1	2.67e-04	17	30	2	GO:0016581
GeneOntologyCellularComponent	CHD-type complex	CHD3 MTA1	2.67e-04	17	30	2	GO:0090545
GeneOntologyCellularComponent	microtubule	CYP2A6 CYP2A7 CYP2A13 MTA1 CCDC57	8.89e-04	533	30	5	GO:0005874
GeneOntologyCellularComponent	cytoplasmic microtubule	CYP2A6 CYP2A7 CYP2A13	9.02e-04	133	30	3	GO:0005881
MousePheno	decreased intestinal cholesterol absorption	CYP2A6 CYP2A7 CYP2A13	2.61e-06	17	23	3	MP:0002647
MousePheno	abnormal intestinal cholesterol absorption	CYP2A6 CYP2A7 CYP2A13	3.71e-06	19	23	3	MP:0002645
MousePheno	abnormal intestinal lipid absorption	CYP2A6 CYP2A7 CYP2A13	1.70e-05	31	23	3	MP:0005342
MousePheno	abnormal bile salt homeostasis	CYP2A6 CYP2A7 CYP2A13	6.02e-05	47	23	3	MP:0005365
MousePheno	abnormal intestinal absorption	CYP2A6 CYP2A7 CYP2A13	1.19e-04	59	23	3	MP:0001666
Domain	Cyt_P450_E_grp-I_CYP2A-like	CYP2A6 CYP2A7 CYP2A13	1.21e-08	4	28	3	IPR008067
Domain	CCDC74_C	CCDC74B CCDC74A	2.17e-06	2	28	2	PF14917
Domain	CCDC74_C	CCDC74B CCDC74A	2.17e-06	2	28	2	IPR029422
Domain	CCDC74	CCDC74B CCDC74A	2.17e-06	2	28	2	IPR033226
Domain	Cyt_P450_E_grp-I	CYP2A6 CYP2A7 CYP2A13	4.10e-05	45	28	3	IPR002401
Domain	Cyt_P450_CS	CYP2A6 CYP2A7 CYP2A13	6.72e-05	53	28	3	IPR017972
Domain	CYTOCHROME_P450	CYP2A6 CYP2A7 CYP2A13	8.36e-05	57	28	3	PS00086
Domain	-	CYP2A6 CYP2A7 CYP2A13	8.81e-05	58	28	3	1.10.630.10
Domain	p450	CYP2A6 CYP2A7 CYP2A13	8.81e-05	58	28	3	PF00067
Domain	Cyt_P450	CYP2A6 CYP2A7 CYP2A13	9.75e-05	60	28	3	IPR001128
Domain	Helicase_C	CHD3 BTAF1 DICER1	5.40e-04	107	28	3	PF00271
Domain	HELICc	CHD3 BTAF1 DICER1	5.40e-04	107	28	3	SM00490
Domain	Helicase_C	CHD3 BTAF1 DICER1	5.54e-04	108	28	3	IPR001650
Domain	HELICASE_CTER	CHD3 BTAF1 DICER1	5.70e-04	109	28	3	PS51194
Domain	HELICASE_ATP_BIND_1	CHD3 BTAF1 DICER1	5.70e-04	109	28	3	PS51192
Domain	DEXDc	CHD3 BTAF1 DICER1	5.70e-04	109	28	3	SM00487
Domain	Helicase_ATP-bd	CHD3 BTAF1 DICER1	5.85e-04	110	28	3	IPR014001
Domain	FG-GAP	FAM234A ITGAL	5.86e-04	24	28	2	PF01839
Domain	FG-GAP	FAM234A ITGAL	5.86e-04	24	28	2	IPR013517
Domain	SNF2_N	CHD3 BTAF1	1.05e-03	32	28	2	PF00176
Domain	SNF2_N	CHD3 BTAF1	1.05e-03	32	28	2	IPR000330
Domain	Myb_DNA-binding	MTA1 CDC5L	1.25e-03	35	28	2	PF00249
Domain	MYB_LIKE	MTA1 CDC5L	1.47e-03	38	28	2	PS50090
Domain	SANT	MTA1 CDC5L	2.54e-03	50	28	2	SM00717
Domain	SANT/Myb	MTA1 CDC5L	2.74e-03	52	28	2	IPR001005
Domain	Zinc_finger_PHD-type_CS	CHD3 JADE3	4.25e-03	65	28	2	IPR019786
Domain	PHD	CHD3 JADE3	5.62e-03	75	28	2	PF00628
Domain	Znf_PHD-finger	CHD3 JADE3	6.22e-03	79	28	2	IPR019787
Domain	PHD	CHD3 JADE3	7.83e-03	89	28	2	SM00249
Domain	Znf_PHD	CHD3 JADE3	8.17e-03	91	28	2	IPR001965
Domain	ZF_PHD_2	CHD3 JADE3	8.88e-03	95	28	2	PS50016
Domain	ZF_PHD_1	CHD3 JADE3	9.06e-03	96	28	2	PS01359
Pathway	REACTOME_CYP2E1_REACTIONS	CYP2A6 CYP2A7 CYP2A13	2.87e-07	11	18	3	M27130
Pathway	REACTOME_CYP2E1_REACTIONS	CYP2A6 CYP2A7 CYP2A13	3.82e-07	12	18	3	MM14847
Pathway	REACTOME_FATTY_ACIDS	CYP2A6 CYP2A7 CYP2A13	1.41e-06	18	18	3	MM14841
Pathway	REACTOME_XENOBIOTICS	CYP2A6 CYP2A7 CYP2A13	3.05e-06	23	18	3	M5372
Pathway	REACTOME_XENOBIOTICS	CYP2A6 CYP2A7 CYP2A13	3.95e-06	25	18	3	MM14846
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_TO_DNA_ADDUCTS	CYP2A6 CYP2A13	1.54e-05	5	18	2	M47808
Pathway	KEGG_DRUG_METABOLISM_OTHER_ENZYMES	CYP2A6 CYP2A7 CYP2A13	3.50e-05	51	18	3	M17726
Pathway	WP_OXIDATION_BY_CYTOCHROME_P450	CYP2A6 CYP2A7 CYP2A13	6.31e-05	62	18	3	M39653
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP2A6 CYP2A7 CYP2A13	6.94e-05	64	18	3	M5650
Pathway	KEGG_RETINOL_METABOLISM	CYP2A6 CYP2A7 CYP2A13	6.94e-05	64	18	3	M9488
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP2A6 CYP2A7 CYP2A13	7.61e-05	66	18	3	MM14839
Pathway	KEGG_DRUG_METABOLISM_CYTOCHROME_P450	CYP2A6 CYP2A7 CYP2A13	9.87e-05	72	18	3	M9257
Pathway	REACTOME_FATTY_ACIDS	CYP2A7 CYP2A13	1.60e-04	15	18	2	M27126
Pathway	REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS	CYP2A6 CYP2A7 CYP2A13	2.94e-04	104	18	3	M738
Pathway	REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS	CYP2A6 CYP2A7 CYP2A13	3.02e-04	105	18	3	MM14842
Pathway	REACTOME_AFLATOXIN_ACTIVATION_AND_DETOXIFICATION	CYP2A6 CYP2A13	4.91e-04	26	18	2	MM15190
Pathway	REACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION	CHD3 MTA1	5.30e-04	27	18	2	MM15537
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_OF_BROWN_AND_BEIGE_ADIPOCYTE_DIFFERENTIATION	CHD3 MTA1	7.01e-04	31	18	2	M48258
Pathway	REACTOME_POTENTIAL_THERAPEUTICS_FOR_SARS	ROCK2 CHD3 MTA1	9.25e-04	154	18	3	M39007
Pathway	WP_EFFECT_OF_PROGERIN_ON_GENES_INVOLVED_IN_PROGERIA	CHD3 MTA1	9.99e-04	37	18	2	M39756
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	CHD3 MTA1 JADE3	1.34e-03	175	18	3	MM14941
Pathway	WP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II	CYP2A6 CYP2A7 CYP2A13	1.52e-03	183	18	3	M39588
Pathway	REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION	CHD3 MTA1	1.61e-03	47	18	2	MM15428
Pathway	REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION_INITIATION	CHD3 MTA1	1.61e-03	47	18	2	M1095
Pathway	REACTOME_HDACS_DEACETYLATE_HISTONES	CHD3 MTA1	2.20e-03	55	18	2	MM14932
Pathway	REACTOME_BIOLOGICAL_OXIDATIONS	CYP2A6 CYP2A7 CYP2A13	2.54e-03	219	18	3	MM14838
Pathway	REACTOME_BIOLOGICAL_OXIDATIONS	CYP2A6 CYP2A7 CYP2A13	2.57e-03	220	18	3	M10320
Pathway	REACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION	CHD3 MTA1	2.70e-03	61	18	2	M27811
Pathway	REACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION	CHD3 MTA1	4.04e-03	75	18	2	M27343
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	CHD3 MTA1 JADE3	4.68e-03	272	18	3	M29619
Pubmed	Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.	CYP2A6 CYP2A7 CYP2A13	5.79e-10	3	30	3	1417950
Pubmed	Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.	CYP2A6 CYP2A7 CYP2A13	5.79e-10	3	30	3	31645370
Pubmed	Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.	CYP2A6 CYP2A7 CYP2A13	5.79e-10	3	30	3	24045421
Pubmed	Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.	CYP2A6 CYP2A7 CYP2A13	5.79e-10	3	30	3	32987105
Pubmed	Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.	CYP2A6 CYP2A7 CYP2A13	5.79e-10	3	30	3	3346244
Pubmed	Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.	CYP2A6 CYP2A7 CYP2A13	5.79e-10	3	30	3	22217847
Pubmed	Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.	CYP2A6 CYP2A7 CYP2A13	5.79e-10	3	30	3	2765478
Pubmed	Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.	CYP2A6 CYP2A7 CYP2A13	5.79e-10	3	30	3	2415518
Pubmed	Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.	CYP2A6 CYP2A7 CYP2A13	5.79e-10	3	30	3	2733794
Pubmed	A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.	CYP2A6 CYP2A7 CYP2A13	5.79e-10	3	30	3	8297477
Pubmed	Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.	CYP2A6 CYP2A7 CYP2A13	5.79e-10	3	30	3	22890016
Pubmed	Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.	CYP2A6 CYP2A7 CYP2A13	5.79e-10	3	30	3	8188299
Pubmed	Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.	CYP2A6 CYP2A7 CYP2A13	5.79e-10	3	30	3	8484736
Pubmed	Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.	CYP2A6 CYP2A7 CYP2A13	5.79e-10	3	30	3	8250953
Pubmed	The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.	CYP2A6 CYP2A7 CYP2A13	5.79e-10	3	30	3	2703500
Pubmed	Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver.	CYP2A6 CYP2A7 CYP2A13	2.32e-09	4	30	3	9408084
Pubmed	A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.	CYP2A6 CYP2A7 CYP2A13	2.32e-09	4	30	3	7565685
Pubmed	Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP.	CYP2A6 CYP2A7 CYP2A13	2.32e-09	4	30	3	10490589
Pubmed	Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice.	CYP2A6 CYP2A7 CYP2A13	2.32e-09	4	30	3	1970547
Pubmed	A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.	CYP2A6 CYP2A7 CYP2A13	1.16e-08	6	30	3	7668294
Pubmed	Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19.	CYP2A6 CYP2A7 CYP2A13	1.16e-08	6	30	3	8587134
Pubmed	Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.	CYP2A6 CYP2A7 CYP2A13	2.02e-08	7	30	3	9630227
Pubmed	Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster.	CYP2A6 CYP2A7 CYP2A13	2.02e-08	7	30	3	14630516
Pubmed	Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder.	CYP2A6 CYP2A7 CYP2A13	4.85e-08	9	30	3	37838304
Pubmed	Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism.	CYP2A6 CYP2A7 CYP2A13	2.62e-07	15	30	3	29968852
Pubmed	Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.	CYP2A6 CYP2A7 CYP2A13	3.91e-07	17	30	3	27197076
Pubmed	Molecular genetics of the human cytochrome P450 monooxygenase superfamily.	CYP2A6 CYP2A7 CYP2A13	6.54e-07	20	30	3	9890157
Pubmed	Expression of CYP2A genes in human liver and extrahepatic tissues.	CYP2A7 CYP2A13	7.19e-07	2	30	2	10353262
Pubmed	Expression and alternative splicing of the cytochrome P-450 CYP2A7.	CYP2A6 CYP2A7	7.19e-07	2	30	2	7864805
Pubmed	Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver.	CYP2A6 CYP2A13	7.19e-07	2	30	2	28298240
Pubmed	Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice.	CYP2A6 CYP2A13	7.19e-07	2	30	2	6309775
Pubmed	Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.	CYP2A6 CYP2A7	7.19e-07	2	30	2	12325023
Pubmed	Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo.	CYP2A6 CYP2A13	7.19e-07	2	30	2	21418183
Pubmed	Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.	CYP2A6 CYP2A13	7.19e-07	2	30	2	22696418
Pubmed	Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.	CYP2A6 CYP2A13	7.19e-07	2	30	2	22262919
Pubmed	Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice.	CYP2A6 CYP2A13	7.19e-07	2	30	2	30876690
Pubmed	CYP2A5 induction and hepatocellular stress: an adaptive response to perturbations of heme homeostasis.	CYP2A6 CYP2A13	7.19e-07	2	30	2	21395539
Pubmed	Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.	CYP2A6 CYP2A13	7.19e-07	2	30	2	25635819
Pubmed	Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions.	CYP2A6 CYP2A13	7.19e-07	2	30	2	12162851
Pubmed	Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh.	CYP2A6 CYP2A13	7.19e-07	2	30	2	1302041
Pubmed	Structural alteration of mouse P450coh by mutation of glycine-207 to proline: spin equilibrium, enzyme kinetics, and heat sensitivity.	CYP2A6 CYP2A13	7.19e-07	2	30	2	8395817
Pubmed	Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice.	CYP2A6 CYP2A13	7.19e-07	2	30	2	25804444
Pubmed	Genetic variation between mice in their metabolism of coumarin and its derivatives.	CYP2A6 CYP2A13	7.19e-07	2	30	2	566237
Pubmed	Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression.	CYP2A6 CYP2A13	7.19e-07	2	30	2	1520280
Pubmed	Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model.	CYP2A6 CYP2A13	7.19e-07	2	30	2	19923441
Pubmed	Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.	CYP2A6 CYP2A13	7.19e-07	2	30	2	23917075
Pubmed	Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression.	CYP2A6 CYP2A13	7.19e-07	2	30	2	12499123
Pubmed	Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5.	CYP2A6 CYP2A13	7.19e-07	2	30	2	30222954
Pubmed	CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.	CYP2A6 CYP2A7	7.19e-07	2	30	2	16636685
Pubmed	Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization.	CYP2A6 CYP2A13	7.19e-07	2	30	2	8611142
Pubmed	Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver.	CYP2A6 CYP2A13	7.19e-07	2	30	2	7543189
Pubmed	Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.	CYP2A6 CYP2A13	7.19e-07	2	30	2	27902773
Pubmed	Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver.	CYP2A6 CYP2A13	7.19e-07	2	30	2	22497566
Pubmed	Characterization and regulation of sex-specific mouse steroid hydroxylase genes.	CYP2A6 CYP2A13	7.19e-07	2	30	2	2372744
Pubmed	Coumarin toxicity in different strains of mice.	CYP2A6 CYP2A13	7.19e-07	2	30	2	665441
Pubmed	The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.	CYP2A6 CYP2A7	7.19e-07	2	30	2	2322567
Pubmed	Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.	CYP2A6 CYP2A13	7.19e-07	2	30	2	21473878
Pubmed	Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.	CYP2A6 CYP2A13	7.19e-07	2	30	2	24104196
Pubmed	CCDC74A/B are K-fiber crosslinkers required for chromosomal alignment.	CCDC74B CCDC74A	7.19e-07	2	30	2	31521166
Pubmed	The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.	CYP2A6 CYP2A13	7.19e-07	2	30	2	7581481
Pubmed	The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.	CYP2A6 CYP2A13	7.19e-07	2	30	2	26363552
Pubmed	Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ.	CYP2A6 CYP2A13	7.19e-07	2	30	2	30154104
Pubmed	Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes.	CYP2A6 CYP2A13	7.19e-07	2	30	2	2712571
Pubmed	Resveratrol improves health and survival of mice on a high-calorie diet.	CYP2A6 CYP2A7 CYP2A13	1.49e-06	26	30	3	17086191
Pubmed	Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes.	CYP2A6 CYP2A13	2.16e-06	3	30	2	18602936
Pubmed	Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress.	CYP2A6 CYP2A13	2.16e-06	3	30	2	18068688
Pubmed	CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.	CYP2A6 CYP2A7	2.16e-06	3	30	2	11960914
Pubmed	Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA.	CYP2A6 CYP2A13	2.16e-06	3	30	2	3219345
Pubmed	Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to Cyp2b and Coh on mouse chromosome 7.	CYP2A6 CYP2A13	2.16e-06	3	30	2	1973143
Pubmed	Zfp30, a KRAB domain containing zinc finger protein gene, maps to mouse chromosome 7.	CYP2A6 CYP2A13	2.16e-06	3	30	2	7849402
Pubmed	A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression.	CYP2A6 CYP2A13	2.16e-06	3	30	2	21252290
Pubmed	Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress.	CYP2A6 CYP2A13	2.16e-06	3	30	2	25478736
Pubmed	Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.	CYP2A6 CYP2A13	2.16e-06	3	30	2	20840855
Pubmed	Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box site.	CYP2A6 CYP2A13	2.16e-06	3	30	2	17466327
Pubmed	Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway.	CYP2A6 CYP2A13	2.16e-06	3	30	2	22552773
Pubmed	CYP2A7 pseudogene transcript affects CYP2A6 expression in human liver by acting as a decoy for miR-126.	CYP2A6 CYP2A7	2.16e-06	3	30	2	25710939
Pubmed	High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis.	CYP2A6 CYP2A13	2.16e-06	3	30	2	32877213
Pubmed	Limited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital.	CYP2A6 CYP2A13	2.16e-06	3	30	2	11106424
Pubmed	Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation.	CYP2A6 CYP2A13	2.16e-06	3	30	2	24191237
Pubmed	Regulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2.	CYP2A6 CYP2A13	2.16e-06	3	30	2	17303623
Pubmed	Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse model.	CYP2A6 CYP2A13	2.16e-06	3	30	2	23073733
Pubmed	Analysis of RNA-protein interactions of mouse liver cytochrome P4502A5 mRNA.	CYP2A6 CYP2A13	4.31e-06	4	30	2	10215609
Pubmed	Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5.	CYP2A6 CYP2A13	4.31e-06	4	30	2	24494203
Pubmed	Repression of 92-kDa type IV collagenase expression by MTA1 is mediated through direct interactions with the promoter via a mechanism, which is both dependent on and independent of histone deacetylation.	CHD3 MTA1	4.31e-06	4	30	2	12431981
Pubmed	Evidence for induced microsomal bilirubin degradation by cytochrome P450 2A5.	CYP2A6 CYP2A13	4.31e-06	4	30	2	16183037
Pubmed	The genes for mouse salivary androgen-binding protein (ABP) subunits alpha and gamma are located on chromosome 7.	CYP2A6 CYP2A13	4.31e-06	4	30	2	3569880
Pubmed	DNA sequence polymorphism in an androgen-regulated gene is associated with alteration in the encoded RNAs.	CYP2A6 CYP2A13	4.31e-06	4	30	2	6188152
Pubmed	Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models.	CYP2A6 CYP2A13	4.31e-06	4	30	2	22228748
Pubmed	Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1.	CHD3 MTA1	7.18e-06	5	30	2	17922035
Pubmed	Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China.	CYP2A6 CYP2A13	7.18e-06	5	30	2	19303722
Pubmed	CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression of E4BP4.	CYP2A6 CYP2A13	7.18e-06	5	30	2	37797722
Pubmed	Lyb-8.2: A new B cell antigen defined and characterized with a monoclonal antibody.	CYP2A6 CYP2A13	7.18e-06	5	30	2	6984010
Pubmed	Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.	CYP2A6 CYP2A7 CYP2A13	7.49e-06	44	30	3	12745259
Pubmed	Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis.	CYP2A6 CYP2A13	1.08e-05	6	30	2	28131861
Pubmed	Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells.	CHD3 MTA1	1.08e-05	6	30	2	20547755
Pubmed	Genetic regulation of coumarin hydroxylase activity in mice. Evidence for single locus control on chromosome.	CYP2A6 CYP2A13	1.08e-05	6	30	2	447675
Pubmed	Host airway proteins interact with Staphylococcus aureus during early pneumonia.	CYP2A6 CYP2A13	1.08e-05	6	30	2	18195024
Pubmed	The IL-2 receptor beta chain gene (Il-2rb) is closely linked to the Pdgfb locus on mouse chromosome 15.	CYP2A6 CYP2A13 ITGAL	1.39e-05	54	30	3	8482578
Pubmed	Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.	CYP2A6 CYP2A7 CYP2A13	1.64e-05	57	30	3	17208939
Pubmed	Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications.	CYP2A6 CYP2A13	2.01e-05	8	30	2	24859727
Interaction	CYP2A7 interactions	CYP2A6 CYP2A7 CYP2A13	2.40e-09	3	28	3	int:CYP2A7
Interaction	CYP2A13 interactions	CYP2A7 CYP2A13	2.78e-05	6	28	2	int:CYP2A13
Interaction	EMILIN3 interactions	MKLN1 CCDC57 DICER1	6.00e-05	55	28	3	int:EMILIN3
Interaction	CYP2A6 interactions	CYP2A6 CYP2A7	6.66e-05	9	28	2	int:CYP2A6
Cytoband	19q13.2	CYP2A6 CYP2A7 CYP2A13	1.69e-04	164	30	3	19q13.2
Cytoband	2q21.1	CCDC74B CCDC74A	6.67e-04	58	30	2	2q21.1
Cytoband	Yp11.2	TSPY4 TSPY9	1.74e-03	94	30	2	Yp11.2
Cytoband	Ensembl 112 genes in cytogenetic band chrYp11	TSPY4 TSPY9	4.34e-03	150	30	2	chrYp11
Cytoband	Ensembl 112 genes in cytogenetic band chr2q21	CCDC74B CCDC74A	4.40e-03	151	30	2	chr2q21
GeneFamily	Cytochrome P450 family 2	CYP2A6 CYP2A7 CYP2A13	5.32e-06	35	18	3	1001
GeneFamily	PHD finger proteins\|NuRD complex	CHD3 MTA1	6.14e-05	12	18	2	1305
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	MTA1 CDC5L	1.25e-03	53	18	2	532
GeneFamily	PHD finger proteins	CHD3 JADE3	3.56e-03	90	18	2	88
Coexpression	WENG_POR_DOSAGE	CYP2A6 CYP2A7 CYP2A13	4.85e-06	30	29	3	MM1199
Coexpression	RASHI_RESPONSE_TO_IONIZING_RADIATION_5	CYP2A6 CYP2A7 CYP2A13 STC2	1.92e-05	145	29	4	MM517
Coexpression	WENG_POR_TARGETS_LIVER_UP	CYP2A6 CYP2A7 CYP2A13	2.75e-05	53	29	3	MM1203
Coexpression	GSE26890_CXCR1_NEG_VS_POS_EFFECTOR_CD8_TCELL_DN	DENND6B CHD3 FAM234A SIPA1L2	6.73e-05	200	29	4	M8558
Coexpression	TABULA_MURIS_SENIS_KIDNEY_BRUSH_CELL_AGEING	CYP2A6 CYP2A7 CYP2A13	7.79e-05	75	29	3	MM3718
ToppCell	Control-Epithelial-Club\|Epithelial / Disease state, Lineage and Cell class	CYP2A6 CYP2A7 CYP2A13 SIPA1L2	6.98e-06	185	30	4	6814b3c94c7558443c038a227b5c8563d2cfeac4
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Ductal_and_Mucinous_Carcinoma-1\|TCGA-Breast / Sample_Type by Project: Shred V9	CYP2A6 CYP2A7 CYP2A13	1.25e-04	145	30	3	1e52e3c615b49e7388cd58a04e74cafac9552447
ToppCell	COVID-19-kidney-Mito-rich_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CYP2A7 SLFN14 STC2	1.25e-04	145	30	3	afed661aef990edb8e7012ab67ace56443520c9f
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____proximal_tube_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FANCC DENND6B SIPA1L2	1.61e-04	158	30	3	1d78578dc1f8ba43dacdccae1082c0b9d749f64d
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TBC1D8 CYP2A6 CYP2A7	1.73e-04	162	30	3	5c9bc3c3857a99d8a3caf359a7eb279ce9cc1c81
ToppCell	Club_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	CYP2A6 DCHS2 CYP2A13	1.89e-04	167	30	3	dbdaaeb3bd9139cb008d9fe24ec031fc5628f136
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROCK2 BTAF1 ITGAL	2.07e-04	172	30	3	574ebdf36e45222bcd907cd2c2ee7ff50ed4573a
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROCK2 BTAF1 ITGAL	2.07e-04	172	30	3	1627fa7035b0e0bbc82a1c0f000d8231254c680a
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-Alox5+_Lymphocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHD3 STC2 CCDC74A	2.10e-04	173	30	3	4c788c1dad1da495b3b5c10f95e779848dfe85dc
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-lymphocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHD3 STC2 CCDC74A	2.10e-04	173	30	3	6e92983d9f8a2a37f23e60a0d5bb1738217897bc
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A6 CYP2A7 CYP2A13	2.14e-04	174	30	3	42f2ba54b4ea4c62482582b0ccdadffae0a5eb4a
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROCK2 BTAF1 ITGAL	2.21e-04	176	30	3	8e89471f838ea81235256cc2470f1c12c9b75f8a
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Mesenchymal_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CCDC74B SIPA1L2 CCDC74A	2.40e-04	181	30	3	9b2d207dc9fc2228a1555ed360286bb7c2d988ff
ToppCell	Ciliated_cells-A-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	CYP2A7 CCDC74B CCDC74A	2.52e-04	184	30	3	07c5a9633ccdcd18771e3230d6198a55c400afa6
ToppCell	18-Distal-Epithelial-Secretory_progenitor\|Distal / Age, Tissue, Lineage and Cell class	CYP2A6 CYP2A7 CYP2A13	2.85e-04	192	30	3	9fae988ecd2ef1231bfd42a678a4903517694cbe
ToppCell	390C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DCHS2 CYP2A13 SIPA1L2	2.85e-04	192	30	3	c6795ceba90f1a5d441dff92a737b9c7d28b06b0
ToppCell	390C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DCHS2 CYP2A13 SIPA1L2	2.85e-04	192	30	3	5d24bb6c6c17a6b803b241d065b31896a7d86c37
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A6 CYP2A7 CYP2A13	2.90e-04	193	30	3	605fc2a25ed6846fb283b2918cfed98df6039d6b
ToppCell	normal_Lung-Epithelial_cells-Club\|normal_Lung / Location, Cell class and cell subclass	CYP2A6 CYP2A7 CYP2A13	2.99e-04	195	30	3	b46544ad5af04f4dbc2643637caa3d2d50d922ae
ToppCell	Epithelial_cells-Club_cells\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	CYP2A6 CYP2A7 SIPA1L2	2.99e-04	195	30	3	b758676abfc4e6930b696d270ecc0ea461b87a54
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-Club\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CYP2A6 CYP2A7 CYP2A13	3.03e-04	196	30	3	4e4c632db73b1340d80bf40a7657cb4821084d3c
ToppCell	normal_Lung-Epithelial_cells-Club\|Epithelial_cells / Location, Cell class and cell subclass	CYP2A6 CYP2A7 CYP2A13	3.12e-04	198	30	3	a9d0109ca05eb3e9c588f9677ec471dd5c092a75
ToppCell	Biopsy_Control_(H.)-Epithelial-SCGB3A2+_SCGB1A1+\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	CYP2A6 CYP2A7 CYP2A13	3.12e-04	198	30	3	a3d4b6e4259ded2193d94d2ff6d48cf67214fc35
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A7 CYP2A13 CCDC57	3.12e-04	198	30	3	e3d1c9428ee6f9bcf9cdaf2192d4ebea8cc2a47c
ToppCell	distal-1-Epithelial-Club\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CYP2A6 CYP2A7 CYP2A13	3.17e-04	199	30	3	8f0a72a95d0310ef2324c6975495c294b5a47cc8
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX-Club\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	CYP2A6 CYP2A7 CYP2A13	3.17e-04	199	30	3	111cfd589ec6795075d8d88d7664bfb23eba5bf6
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Club-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CYP2A6 CYP2A7 CYP2A13	3.17e-04	199	30	3	d583290a1d288b749ad17bc501c1487268c6551c
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Club\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CYP2A6 CYP2A7 CYP2A13	3.17e-04	199	30	3	2b17694cffbec28a2c8f165dfcff6bab94aa0f4c
ToppCell	distal-Epithelial-Club-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CYP2A6 CYP2A7 CYP2A13	3.17e-04	199	30	3	685cefbe6ff5db8b578e50b5849524ac2f347d0c
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ROCK2 SIPA1L2 STC2	3.22e-04	200	30	3	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ROCK2 SIPA1L2 STC2	3.22e-04	200	30	3	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	(09)_Interm._secr.>cil.\|World / shred by cell type by condition	DENND6B CCDC74B CCDC74A	3.22e-04	200	30	3	3305e14dba12e94da42f0414fdc7a2c8caf0a183
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ROCK2 SIPA1L2 STC2	3.22e-04	200	30	3	2d07237022b409c4fac6fcf99b68c8affb3007cd
Drug	2'-methoxyacetophenone	CYP2A6 CYP2A7 CYP2A13	1.67e-09	3	28	3	CID000068481
Drug	N-nitrosomethylaniline	CYP2A6 CYP2A7 CYP2A13	6.01e-07	14	28	3	CID000011957
Drug	nicotine imine	CYP2A6 CYP2A13	1.46e-06	2	28	2	ctd:C034629
Drug	propargyl ether	CYP2A6 CYP2A13	1.46e-06	2	28	2	ctd:C531209
Drug	alpha-nicotyrine	CYP2A6 CYP2A13	1.46e-06	2	28	2	ctd:C008615
Drug	N-nitrosoguvacoline	CYP2A6 CYP2A13	1.46e-06	2	28	2	ctd:C036676
Drug	Hempa	CYP2A6 CYP2A13	1.46e-06	2	28	2	ctd:D006492
Drug	NSC35549	CYP2A6 CYP2A7 CYP2A13	2.53e-06	22	28	3	CID000411697
Drug	Isoconazole [27523-40-6]; Down 200; 9.6uM; HL60; HG-U133A	FANCC ROCK2 MPHOSPH9 CDC5L STC2	3.85e-06	197	28	5	1372_DN
Drug	C14845	CYP2A6 CYP2A7 CYP2A13	4.78e-06	27	28	3	CID011954064
Drug	BP-9,10-oxide	CYP2A6 CYP2A7 CYP2A13	4.78e-06	27	28	3	CID000037456
Drug	Brn 4136738	CYP2A6 CYP2A7 CYP2A13	4.78e-06	27	28	3	CID000050331
Drug	9-OH-BaP-4,5-oxide	CYP2A6 CYP2A7 CYP2A13	5.35e-06	28	28	3	CID000115064
Drug	11-H-14,15-EETA	CYP2A6 CYP2A7 CYP2A13	6.61e-06	30	28	3	CID011954058
Drug	19-hydroxytestosterone	CYP2A6 CYP2A7 CYP2A13	6.61e-06	30	28	3	CID000150968
Drug	BP-7,8-oxide	CYP2A6 CYP2A7 CYP2A13	8.07e-06	32	28	3	CID000037455
Drug	NMPA	CYP2A6 CYP2A13	8.74e-06	4	28	2	CID000132101
Drug	N'-nitrosoanatabine	CYP2A6 CYP2A13	8.74e-06	4	28	2	ctd:C032978
Drug	TCEO	CYP2A6 CYP2A7 CYP2A13	9.72e-06	34	28	3	CID000028167
Drug	12(13)-EpOME	CYP2A6 CYP2A7 CYP2A13	9.72e-06	34	28	3	CID000001416
Drug	AC1O5XSP	CYP2A6 CYP2A7 CYP2A13	9.72e-06	34	28	3	CID006442739
Drug	AC1L1CJI	CYP2A6 CYP2A7 CYP2A13	1.06e-05	35	28	3	CID000001929
Drug	15-H-11,12-EETA	CYP2A6 CYP2A7 CYP2A13	1.16e-05	36	28	3	CID011954042
Drug	hexamethylphosphoramide	CYP2A6 CYP2A7 CYP2A13	1.16e-05	36	28	3	CID000012679
Drug	AC1L3NGJ	CYP2A6 CYP2A7 CYP2A13	1.16e-05	36	28	3	CID000092121
Drug	8-MOP	FANCC CYP2A6 CYP2A7 CYP2A13	1.27e-05	118	28	4	CID000004114
Drug	N-methyl-N-2-(methylsulfinyl)ethylpropionic acid amide	CYP2A6 CYP2A13	1.46e-05	5	28	2	ctd:C062567
Drug	benzyl selenocyanate	CYP2A6 CYP2A13	1.46e-05	5	28	2	ctd:C054108
Drug	11,14,15-THET	CYP2A6 CYP2A7 CYP2A13	1.48e-05	39	28	3	CID006439531
Drug	11,12,15-trihydroxyeicosatrienoic acid	CYP2A6 CYP2A7 CYP2A13	1.85e-05	42	28	3	CID006439610
Drug	polybrominated biphenyl	CYP2A6 CYP2A7 CYP2A13	2.13e-05	44	28	3	CID000042948
Drug	acenaphthene-1-ol	CYP2A6 CYP2A13	2.18e-05	6	28	2	ctd:C023723
Drug	AC1L196J	CYP2A6 CYP2A13	2.18e-05	6	28	2	CID000000415
Drug	menthofuran	CYP2A6 CYP2A13	2.18e-05	6	28	2	ctd:C054487
Drug	N'-nitrosoanabasine	CYP2A6 CYP2A13	2.18e-05	6	28	2	ctd:C010257
Drug	naphthalene-1,2-dihydrodiol	CYP2A6 CYP2A7 CYP2A13	2.28e-05	45	28	3	CID000000362
Drug	aminoglutethimide	CYP2A6 CYP2A7 CYP2A13 ITGAL	2.30e-05	137	28	4	CID000002145
Drug	C14802	CYP2A6 CYP2A7 CYP2A13	2.60e-05	47	28	3	CID011954053
Drug	C14800	CYP2A6 CYP2A7 CYP2A13	2.78e-05	48	28	3	CID011954051
Drug	nitro-L	CYP2A6 CYP2A7 CYP2A13	2.78e-05	48	28	3	CID000006849
Drug	19-HETE	CYP2A6 CYP2A7 CYP2A13	2.95e-05	49	28	3	CID006439528
Drug	bromobenzene-3,4-oxide	CYP2A6 CYP2A7 CYP2A13	2.95e-05	49	28	3	CID000108121
Drug	acenaphthene	CYP2A6 CYP2A13	3.05e-05	7	28	2	ctd:C042552
Drug	6-hydroxymelatonin	CYP2A6 CYP2A7 CYP2A13	3.14e-05	50	28	3	CID000001864
Drug	1,1-dichloroethylene epoxide	CYP2A6 CYP2A7 CYP2A13	3.14e-05	50	28	3	CID000119521
Drug	bromobenzene-2,3-oxide	CYP2A6 CYP2A7 CYP2A13	3.14e-05	50	28	3	CID003036760
Drug	mepivacaine	CYP2A6 CYP2A7 CYP2A13	3.33e-05	51	28	3	CID000004062
Drug	naphthalene epoxide	CYP2A6 CYP2A7 CYP2A13	3.33e-05	51	28	3	CID000108063
Drug	9-hydroxybenzo(a)pyrene	CYP2A6 CYP2A7 CYP2A13	3.74e-05	53	28	3	CID000028598
Drug	dichloroacetaldehyde	CYP2A6 CYP2A7 CYP2A13	3.96e-05	54	28	3	CID000006576
Drug	chloroacetyl chloride	CYP2A6 CYP2A7 CYP2A13	4.19e-05	55	28	3	CID000006577
Drug	1,2-dihydroxynaphthalene	CYP2A6 CYP2A7 CYP2A13	4.66e-05	57	28	3	CID000011318
Drug	bromoacetaldehyde	CYP2A6 CYP2A7 CYP2A13	4.91e-05	58	28	3	CID000105131
Drug	N-nitrosoguvacoline	CYP2A6 CYP2A13	5.22e-05	9	28	2	CID000062103
Drug	acenaphthylene	CYP2A6 CYP2A13	5.22e-05	9	28	2	ctd:C042553
Drug	3-(methylnitrosamino)propionaldehyde	CYP2A6 CYP2A13	5.22e-05	9	28	2	CID000098533
Drug	1,1-dichloroethylene	CYP2A6 CYP2A7 CYP2A13	5.44e-05	60	28	3	CID000006366
Drug	BP-4,5-oxide	CYP2A6 CYP2A7 CYP2A13	5.72e-05	61	28	3	CID000037786
Drug	chlorzoxazone	CYP2A6 CYP2A7 CYP2A13	6.30e-05	63	28	3	CID000002733
Drug	propoxyphene	CYP2A6 CYP2A7 CYP2A13	7.57e-05	67	28	3	CID000010100
Drug	piperonyl butoxide	CYP2A6 CYP2A7 CYP2A13	7.57e-05	67	28	3	CID000005794
Drug	5,6-epoxyeicosatrienoic acid	CYP2A6 CYP2A7 CYP2A13	7.91e-05	68	28	3	CID000001778
Drug	D-702	CYP2A6 CYP2A13	7.97e-05	11	28	2	CID000054077
Drug	8(9)-EET	CYP2A6 CYP2A7 CYP2A13	8.27e-05	69	28	3	CID000001901
Drug	Tranylcypromine hydrochloride [1986-47-6]; Down 200; 23.6uM; PC3; HT_HG-U133A	FANCC CHD3 MPHOSPH9 CDC5L	8.56e-05	192	28	4	2101_DN
Drug	4-bromophenol	CYP2A6 CYP2A7 CYP2A13	8.63e-05	70	28	3	CID000007808
Drug	1h1q	CYP2A6 CYP2A7 CYP2A13	8.63e-05	70	28	3	CID000001540
Drug	1,2-dibromoethane	CYP2A6 CYP2A7 CYP2A13	9.00e-05	71	28	3	CID000007839
Drug	carteolol	CYP2A6 CYP2A7 CYP2A13	9.39e-05	72	28	3	CID000002583
Drug	Isoxsuprine hydrochloride [579-56-6]; Down 200; 11.8uM; PC3; HG-U133A	MKLN1 MPHOSPH9 CDC5L STC2	9.65e-05	198	28	4	1904_DN
Drug	Hexylcaine hydrochloride [532-76-3]; Down 200; 13.4uM; PC3; HT_HG-U133A	MPHOSPH9 MTA1 CDC5L ANKRD2	9.65e-05	198	28	4	5768_DN
Drug	2,2,2-trichloroethanol	CYP2A6 CYP2A7 CYP2A13	9.78e-05	73	28	3	CID000008259
Drug	chloral	CYP2A6 CYP2A7 CYP2A13	9.78e-05	73	28	3	CID000006407
Drug	7-hydroxycoumarin	CYP2A6 CYP2A7 CYP2A13	1.06e-04	75	28	3	CID005281426
Drug	debrisoquine	CYP2A6 CYP2A7 CYP2A13	1.06e-04	75	28	3	CID000002965
Drug	Skatole	CYP2A6 CYP2A13	1.13e-04	13	28	2	ctd:D012862
Drug	d 6-20	CYP2A6 CYP2A13	1.13e-04	13	28	2	CID000161569
Drug	LFA703	ROCK2 ITGAL	1.13e-04	13	28	2	CID000449169
Drug	BP-7,8-diol	CYP2A6 CYP2A7 CYP2A13	1.19e-04	78	28	3	CID000025892
Drug	C20H32O4	CYP2A6 CYP2A7 CYP2A13	1.19e-04	78	28	3	CID000001440
Drug	trimipramine	CYP2A6 CYP2A7 CYP2A13	1.28e-04	80	28	3	CID000005584
Drug	MnPN	CYP2A6 CYP2A13	1.32e-04	14	28	2	CID000062163
Drug	4-hydroxypyrazole	FANCC CYP2A6	1.32e-04	14	28	2	CID000119218
Drug	N'-nitrosonornicotine	CYP2A6 CYP2A13	1.52e-04	15	28	2	ctd:C008655
Drug	diosmetin	CYP2A6 CYP2A7 CYP2A13	1.54e-04	85	28	3	CID005281612
Drug	trichloroethylene	CYP2A6 CYP2A7 CYP2A13	1.70e-04	88	28	3	CID000006575
Drug	mephenytoin	CYP2A6 CYP2A7 CYP2A13	1.70e-04	88	28	3	CID000004060
Drug	14(15)-EpETrE	CYP2A6 CYP2A7 CYP2A13	1.76e-04	89	28	3	CID000001431
Drug	parathion	CYP2A6 CYP2A7 CYP2A13	1.88e-04	91	28	3	CID000000991
Drug	Endosulfan	ROCK2 CYP2A6 CYP2A7 CYP2A13 STC2	1.93e-04	447	28	5	ctd:D004726
Drug	2-naphthol	CYP2A6 CYP2A7 CYP2A13	2.01e-04	93	28	3	CID000008663
Drug	tienilic acid	CYP2A6 CYP2A7 CYP2A13	2.01e-04	93	28	3	CID000038409
Drug	AC1L1BEQ	CYP2A6 CYP2A7 CYP2A13	2.01e-04	93	28	3	CID000001407
Drug	lansoprazole	CYP2A6 CYP2A7 CYP2A13	2.01e-04	93	28	3	CID000003883
Drug	D 703	CYP2A6 CYP2A13	2.20e-04	18	28	2	CID000054088
Drug	bromobenzene	CYP2A6 CYP2A7 CYP2A13	2.27e-04	97	28	3	CID000007961
Drug	S)-cotinine	CYP2A6 CYP2A7 CYP2A13	2.27e-04	97	28	3	CID000000408
Drug	PCB 77	CYP2A6 CYP2A7 CYP2A13	2.34e-04	98	28	3	CID000036187
Drug	D 617	CYP2A6 CYP2A13	2.46e-04	19	28	2	CID000093168
Drug	AC1L1KIN	CYP2A6 CYP2A7 CYP2A13	2.49e-04	100	28	3	CID000005516
Disease	nicotine metabolite ratio	CYP2A6 CYP2A7	3.82e-05	12	23	2	EFO_0007794
Disease	caffeine metabolite measurement	CYP2A6 CYP2A7	9.86e-05	19	23	2	EFO_0007872
Disease	Endometrioma	MTA1 STC2 DICER1	2.61e-04	161	23	3	C0269102
Disease	Endometriosis	MTA1 STC2 DICER1	2.61e-04	161	23	3	C0014175
Disease	smooth surface dental caries	SIPA1L2 ITGAL	1.07e-03	62	23	2	EFO_0006339
Disease	chin morphology measurement	CDC5L DICER1	1.36e-03	70	23	2	EFO_0007842
Disease	Ischemic stroke	DCHS2 CHD3 CDC5L	1.97e-03	324	23	3	HP_0002140
Disease	velopharyngeal dysfunction	DCHS2 ZNF532	4.05e-03	122	23	2	EFO_0009336
Disease	cigarettes per day measurement	CYP2A6 CYP2A7 BTAF1	4.61e-03	438	23	3	EFO_0006525
Disease	bilirubin measurement	DCHS2 CHD3 FAM234A	4.73e-03	442	23	3	EFO_0004570
Disease	androgenetic alopecia	MKLN1 CDC5L	4.79e-03	133	23	2	EFO_0004191
Disease	stroke	CHD3 CDC5L	5.59e-03	144	23	2	EFO_0000712
Disease	PR interval	MKLN1 CDC5L SIPA1L2	6.47e-03	495	23	3	EFO_0004462

Protein segments in the cluster

Peptide	Gene	Start	Entry
MLDHKDLEAEIHPLK	FAM234A	1	Q9H0X4
EEEEKLLHLAKLMPT	CDC5L	66	Q99459
LLMKHPEVEAKVHEE	CYP2A6	316	P11509
DIHPHMVEEDIDAKK	C16orf78	241	Q8WTQ4
KLHKIGELDDHLMPV	DICER1	701	Q9UPY3
RHKEMALKLEALHLE	DENND6B	501	Q8NEG7
EMLAKLHEEIEHLKR	CCDC74A	66	Q96AQ1
EMLAKLHEEIEHLKR	CCDC74B	66	Q96LY2
KLEEKDMHHSLPETL	MPHOSPH9	216	Q99550
FNDIAKLKDEHLHMP	DCHS2	3251	Q6V1P9
LPMDLLVLEDEKHHG	ANKRD2	66	Q9GZV1
LLMKHPEVEAKVHEE	CYP2A13	316	Q16696
MLDIVEHDLLKPHLP	BTAF1	1656	O14981
DQIKKLHDLLGPHML	CHD3	951	Q12873
LLMKHPEVEAKVHEE	CYP2A7	316	P20853
HLPSLEKAMLHLFEK	FANCC	246	Q00597
LEKHLEDVLDPLKMS	CCDC57	596	Q2TAC2
KDLISAMKLPDSHHI	JADE3	46	Q92613
DHKELEGLMKTLIHP	SLFN14	416	P0C7P3
KIALEHPMLTDIHDK	MKLN1	201	Q9UL63
HVLSKEDFLKLMLPD	SIPA1L2	1446	Q9P2F8
DPDALLKHVKHMLLL	ITGAL	216	P20701
EMVDLPEKLKHQLRH	MTA1	91	Q13330
MKPSELLKAEAHHAE	SDF2	196	Q99470
EEEKHPVHLCKIMLF	TSPY9	196	A0A494C1R9
HVQLMHGIKDPDLKE	ZNF532	1106	Q9HCE3
EEEKHPVHLCKIMLF	TSPY4	196	P0CV99
IVEMIHFKDLLLHEP	STC2	156	O76061
ELIKGHLPELAEHMN	TBC1D8	641	O95759
IHRDVKPDNMLLDKH	ROCK2	211	O75116