Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainROR_rcpt

RORB RORC

2.55e-053552IPR003079
DomainGUANYLATE_KINASE_2

CARD11 CARD14

2.07e-0323552PS50052
DomainGUANYLATE_KINASE_1

CARD11 CARD14

2.07e-0323552PS00856
DomainCARD

CARD11 CARD14

3.06e-0328552PF00619
DomainP-loop_NTPase

WSCD1 RAB36 ABCB7 GAL3ST1 CARD11 CHD1 IQCN CARD14

3.20e-03848558IPR027417
Pubmed

Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment.

MYBPC1 MYBPC2

2.73e-0625828375400
Pubmed

Fast and slow skeletal myosin binding protein-C and aging.

MYBPC1 MYBPC2

2.73e-06258236409445
Pubmed

Isoform-specific interaction of the myosin-binding proteins (MyBPs) with skeletal and cardiac myosin is a property of the C-terminal immunoglobulin domain.

MYBPC1 MYBPC2

2.73e-0625829252413
Pubmed

CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B.

CARD11 CARD14

8.19e-06358211278692
Pubmed

The C-terminal IgI domains of myosin-binding proteins C and H (MyBP-C and MyBP-H) are both necessary and sufficient for the intracellular crosslinking of sarcomeric myosin in transfected non-muscle cells.

MYBPC1 MYBPC2

8.19e-06358212154082
Pubmed

Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation.

CARD11 CARD14

1.64e-05458211356195
Pubmed

Differential expression of C-protein isoforms in developing and degenerating mouse striated muscles.

MYBPC1 MYBPC2

2.72e-05558210024132
Pubmed

Isoform transitions of the myosin binding protein C family in developing human and mouse muscles: lack of isoform transcomplementation in cardiac muscle.

MYBPC1 MYBPC2

2.72e-0555829440711
Pubmed

Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B.

CARD11 CARD14

2.72e-05558211259443
Pubmed

Generation and analysis of 280,000 human expressed sequence tags.

CARD11 SERAC1 AARSD1 MYBPC1 AKR7A2 MYBPC2

3.43e-053685868889549
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

STRN3 PTGES2 ABCB7 ATP6AP1 WASHC4 CEP72 FASTKD1 EIF3C

3.46e-0575458833060197
Pubmed

Immunohistochemical characterization of the orphan nuclear receptor ROR alpha in the mouse nervous system.

RORB RORC

4.08e-05658214966198
Pubmed

DNA cloning using in vitro site-specific recombination.

CATSPERZ RAB36 PTGES2 ATP6AP1 MTCP1 RORC IQCN MYBPC1

4.98e-0579458811076863
Pubmed

Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression.

KDM2B RORC

9.77e-05958228319097
Pubmed

Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6.

PTGES2 MRPS34 AKR7A2

1.09e-045558336758106
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

USP34 GAK WASHC4 MAP1S CHD1 EIF3C PDE7B AKR7A2

1.28e-0491058836736316
Pubmed

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.

PTGES2 GAK ABCB7 SERAC1 NOL9 NDUFB8 AKR7A2

1.42e-0468658728380382
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

STRN3 PTGES2 ABCB7 ATP6AP1 WIZ SURF1 FASTKD1 MRPS34 NOL9 NDUFB8

1.67e-041496581032877691
Pubmed

Thalamocortical axons regulate neurogenesis and laminar fates in the early sensory cortex.

RORB RORC

1.78e-041258235613048
Pubmed

Molecular diversity of myofibrillar proteins: gene regulation and functional significance.

MYBPC1 MYBPC2

1.78e-04125828618961
Pubmed

The LIFEdb database in 2006.

CATSPERZ PTGES2 ATP6AP1 MTCP1 RORC IQCN MYBPC1

1.90e-0472058716381901
Pubmed

From ORFeome to biology: a functional genomics pipeline.

CATSPERZ PTGES2 ATP6AP1 MTCP1 RORC IQCN MYBPC1

1.94e-0472258715489336
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

USP34 PTGES2 WASHC4 WIZ MAP1S ZBTB47 RORB EIF3C WDFY3

2.60e-04128558935914814
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

USP34 ENDOD1 ATP6AP1 GAL3ST1 FASTKD1 EXTL2 WDFY3 AKR7A2

3.62e-04106158833845483
Pubmed

The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes.

PTGES2 ABCB7 SURF1 NDUFB8 AKR7A2

4.43e-0438258529222160
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

USP34 ZBTB47 KDM2B MRPS34 CARD14

5.21e-0439658526687479
Pubmed

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

PTGES2 ABCB7 SURF1 FASTKD1 MRPS34 SERAC1 NDUFB8 AKR7A2

5.69e-04113658834800366
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

PLCD3 STRN3 ATP6AP1 WIZ KDM2B MRPS34 CHD1 EIF3C NOL9

7.86e-04149758931527615
Pubmed

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.

WIZ MRPS34 CHD1 NOL9

8.28e-0425158428077445
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

ENDOD1 GAK ABCB7 ATP6AP1 MAP1S CEP72 MRPS34 AKR7A2

1.34e-03129758833545068
Pubmed

Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy.

MYBPC1 MYBPC2

1.66e-033658223236519
GeneFamilyFibronectin type III domain containing|I-set domain containing|Myosin binding proteins

MYBPC1 MYBPC2

1.07e-048362658
GeneFamilyCalcium voltage-gated channel subunits|Membrane associated guanylate kinases

CARD11 CARD14

1.22e-0326362904
GeneFamilyWD repeat domain containing|Caspase recruitment domain containing|Apoptosome

CARD11 CARD14

1.62e-0330362959
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

PXDNL MYBPC1 MYBPC2

3.99e-03161363593
GeneFamilyNuclear hormone receptors

RORB RORC

4.27e-034936271
ToppCellSubstantia_nigra-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ZNF469 CEP72 PABPC5 AARSD1 MYBPC1

1.21e-07905853817a5b0235e632d976ea565175bdbebbd959bf0
ToppCellSubstantia_nigra-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ZNF469 CEP72 PABPC5 AARSD1 MYBPC1

1.21e-0790585a528f5dcee1a356dea89ff2588d2e0f276f2d5fc
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAS2 RORB EXTL2 PDE7B

8.51e-05178584674ee5095b98929c29e4f6bd56029a336cc4a38c
ToppCell10x3'2.3-week_12-13-Myeloid_macrophage-stroma-erythroid_macrophage|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ZNF469 PI16 PABPC5 SPAG17

8.69e-05179584c17ae394b855f01f8ca1765c416fd8b34a96e60b
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAS2 RORB EXTL2 PDE7B

8.88e-05180584fd8c2059fcb382ffbfe19e598e37a49e1d5637b5
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAS2 RORB EXTL2 PDE7B

8.88e-051805845391d23817f5cc88a0871ddb98968897c839f464
ToppCellAdult-Epithelial-ciliated_cell-D122|Adult / Lineage, Cell type, age group and donor

RAB36 TTLL9 SPAG17 KLHL32

9.27e-051825847ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCelldroplet-Limb_Muscle-nan-3m-Mesenchymal-skeletal_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RORC PTGES3L MYBPC1 MYBPC2

9.27e-05182584edfc598b7199ca1d8a399b264ab863c299b1eede
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

RAB36 TTLL9 SPAG17 KLHL32

9.67e-051845845daff849625f2f41d56615569c0ed59cd733b34c
ToppCelldroplet-Limb_Muscle-nan-3m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAB36 IQGAP2 TTLL9 GAL3ST1

9.87e-05185584554c5d812197fbf66bf279fcc953277e926ade15
ToppCellAdult-Epithelial-ciliated_cell-D175|Adult / Lineage, Cell type, age group and donor

RAB36 TTLL9 SPAG17 KLHL32

9.87e-0518558430f4980dee6cd5959655f8d74049f3bfb5312611
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RAB36 TTLL9 SPAG17 KLHL32

9.87e-051855843e39a3cb534dfe2301930f3e2f7e8cefb522c158
ToppCelldroplet-Limb_Muscle-nan-24m-Mesenchymal-skeletal_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RORC PTGES3L MYBPC1 MYBPC2

9.87e-051855849245c322aae8bb9065d50dada198a5ee143a3444
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RAB36 TTLL9 SPAG17 KLHL32

1.03e-041875849e10ed56090d82589bc457788282f664b70ace4b
ToppCellEpithelial-ciliated_cell|World / Lineage, Cell type, age group and donor

RAB36 TTLL9 SPAG17 KLHL32

1.05e-0418858461a459f3fe57e5728efc72637ff2edc2d343492b
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

RAB36 TTLL9 SPAG17 KLHL32

1.05e-041885842b6dfc88be9ded7b88da9fe78a9cd9f9b3af8af3
ToppCellCOVID-19-lung-Ciliated|COVID-19 / Disease (COVID-19 only), tissue and cell type

RAB36 TTLL9 SPAG17 KLHL32

1.07e-04189584a2da5debd10f27b1280b40141ef0bfef007cc72c
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

RAB36 TTLL9 SPAG17 KLHL32

1.07e-0418958468a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCellAdult-Epithelial-ciliated_cell|Adult / Lineage, Cell type, age group and donor

RAB36 TTLL9 SPAG17 KLHL32

1.07e-04189584b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCellCOVID-19-lung-Ciliated|lung / Disease (COVID-19 only), tissue and cell type

RAB36 TTLL9 SPAG17 KLHL32

1.07e-0418958427329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCellCOVID-19_Convalescent-Classical_Monocyte-cMono_3|COVID-19_Convalescent / Disease condition and Cell class

ZNF487 ENDOD1 GBGT1 AARSD1

1.07e-04189584732e8dcffcb634ca2968f9170c9c4b31dd5d4206
ToppCellTracheal-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MTCP1 IQGAP2 CARD11 ADCY7

1.16e-0419358491a1c9b8390cbd881db8c49d8f34feca0d1067d6
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-4|TCGA-Skin / Sample_Type by Project: Shred V9

PTGES2 ATP6AP1 MAP1S AKR7A2

1.31e-04199584bbda9060918797303984ca2b64e9bb73fdacd0c4
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

KIAA0408 IQGAP2 EXTL2 PDE7B

1.31e-0419958438cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCellLPS_IL1RA-Epithelial_airway-airway_epithelial-Ciliated|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

RAB36 TTLL9 SPAG17 KLHL32

1.33e-042005844992dbf0514d674017315dbd20d91dfec0c608e9
Diseasereticulocyte measurement

USP34 ENDOD1 ZNF469 WIZ IQGAP2 RORB DEPDC5 NOL9 MYBPC1

1.75e-041053579EFO_0010700
Diseasemean fractional anisotropy measurement

STRN3 GAL3ST1 WDFY3

8.34e-0495573EFO_0008399
Diseaseneuroimaging measurement, brain volume measurement

USP34 RAB36 STRN3 GAL3ST1

2.28e-03286574EFO_0004346, EFO_0006930

Protein segments in the cluster

PeptideGeneStartEntry
LAMEEWHHEREHYNL

PI16

101

Q6UXB8
HMPHRAYWAEQQSRL

CATSPERZ

131

Q9NTU4
VTSAALRWMYHHSQL

AKR7A2

291

O43488
EHSWMSNQTDLHYVL

GPR19

46

Q15760
RVDWERRFDHMQQHS

AARSD1

96

Q9BTE6
AQHRAEVEQMHWSYQ

CEP72

611

Q9P209
QYDVWSHDVSLANRM

ADCY7

391

P51828
RDYRYHSDWQMDHRA

CHD1

1656

O14646
HLAREMQAEYWSVSA

RAB36

256

O95755
YSTRRDQARHWQMLH

IQCN

986

Q9H0B3
WDRMHLFQEAIAHRF

DEPDC5

1466

O75140
SHLNLDDRRWSMQNF

NOL9

201

Q5SY16
DSVAMHTWYAETHAR

MAP1S

1016

Q66K74
SGMWHRAEHALQRSY

EXTL2

281

Q9UBQ6
QERWYVNLHSLMDRA

ENDOD1

171

O94919
YQNMSVLENHHWRST

PDE7B

236

Q9NP56
RSYRNMLHEHDWRPS

KIAA0408

531

Q6ZU52
HWHLDMYNRNRVDTS

NDUFB8

106

O95169
LSMYTWLEIQRHNHE

FADS2B

56

A8MWK0
HFDSLAAANRAIWHM

PABPC5

151

Q96DU9
ALAAMHTLWFREHNR

PXDNL

966

A1KZ92
HALHSRWYQARDLML

EIF3C

576

Q99613
RATAWNMLDSHLYRH

GAL3ST1

296

Q99999
YNICRNMHAWLRQDH

GAK

486

O14976
HREVWMAVFSYLSHQ

KDM2B

1066

Q8NHM5
WHAHRVNSYTMKDTA

CARD14

716

Q9BXL6
IMAAWREESHLNRHF

GBGT1

291

Q8N5D6
TSVLRWIQHDHMYLD

FASTKD1

456

Q53R41
TQWVDRNMRSHHRFQ

S100PBP

386

Q96BU1
VHVRDTMYQDRHEWL

CARD11

801

Q9BXL7
SDMHQYSQWLASRHE

GAS2

16

O43903
SEAREIEHVMYHDWR

MRPS34

126

P82930
YIQHEWARFEMERAH

STRN3

71

Q13033
AVREMSETHHWHDYQ

SERAC1

151

Q96JX3
RYMDNNSRLWQIQHH

MTCP1

76

P56278
HFRHTDNTVQWLRAM

IQGAP2

106

Q13576
MLQDQEHHWYLHDRY

SERPINA4

246

P29622
DDLMQHTHIQPWYLR

PTGES2

351

Q9H7Z7
HARSHLRQMGVTEWY

WIZ

1061

O95785
NPERNHWHYRDLEAM

SURF1

221

Q15526
LDWKRQHQHYLESMQ

SPAG17

356

Q6Q759
YSEMWHTQSSRVQNH

ABCB7

701

O75027
ADRMFHSVREAWYSA

WDFY3

2821

Q8IZQ1
HSVREAWYSASKHNM

WDFY3

2826

Q8IZQ1
MWERCAHHLTEAIQY

RORC

316

P51449
AMSQRERLDHWIHSY

PLCD3

176

Q8N3E9
TMEELHQLAWQTHTY

RORB

241

Q92753
ARHWFTMERLEVHSN

ATP6AP1

336

Q15904
NNRWYLEKHMNVTHS

ZBTB47

446

Q9UFB7
VADVWMYNEHLREHA

ZNF469

3156

Q96JG9
SWLRENFDHTYMDEH

TTLL9

81

Q3SXZ7
HDWATYSEMRNLATQ

WASHC4

746

Q2M389
SRHEVSHYSMWLLVS

USP34

1621

Q70CQ2
QLRRRWFHHFMSDSQ

WSCD1

111

Q658N2
GAAMARQHARTLWYD

PTGES3L

41

E9PB15
WQHLDSAQRTPYRDM

ZNF487

51

B1APH4
AVRWLEHNCHYQYMD

KLHL32

211

Q96NJ5
MEWFTVIEHYHRTSA

MYBPC1

976

Q00872
TMEWFNVYERNRHTS

MYBPC2

976

Q14324