Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	TRPM6 TRPM7 ANXA5 CATSPER3 SLC30A4 PKDREJ SCN1A SCN9A SCN10A SLC39A6 TRPM1 KCNAB3 SLC38A3	6.57e-06	465	124	13	GO:0046873
GeneOntologyMolecularFunction	transporter activity	TRPM6 TRPM7 ANXA5 FLVCR1 ATG2B GRID1 CATSPER3 SLC30A4 PKDREJ MFSD12 CIDEA SLC44A1 PIEZO2 ABCA6 SCN1A SCN9A SCN10A SLC39A6 SLC47A1 TRPM1 KCNAB3 SLC38A3	1.34e-05	1289	124	22	GO:0005215
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	TRPM6 TRPM7 ANXA5 CATSPER3 SLC30A4 PKDREJ PIEZO2 SCN1A SCN9A SCN10A SLC39A6 SLC47A1 TRPM1 KCNAB3 SLC38A3	1.60e-05	664	124	15	GO:0008324
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	TRPM6 TRPM7 ANXA5 GRID1 CATSPER3 SLC30A4 PKDREJ PIEZO2 SCN1A SCN9A SCN10A SLC39A6 SLC47A1 TRPM1 KCNAB3 SLC38A3	3.26e-05	793	124	16	GO:0015075
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	TRPM6 TRPM7 ANXA5 CATSPER3 SLC30A4 PKDREJ SCN1A SCN9A SCN10A SLC39A6 SLC47A1 TRPM1 KCNAB3 SLC38A3	3.55e-05	627	124	14	GO:0022890
GeneOntologyMolecularFunction	transmembrane transporter activity	TRPM6 TRPM7 ANXA5 FLVCR1 GRID1 CATSPER3 SLC30A4 PKDREJ MFSD12 SLC44A1 PIEZO2 ABCA6 SCN1A SCN9A SCN10A SLC39A6 SLC47A1 TRPM1 KCNAB3 SLC38A3	3.85e-05	1180	124	20	GO:0022857
GeneOntologyMolecularFunction	monoatomic cation channel activity	TRPM6 TRPM7 CATSPER3 PKDREJ PIEZO2 SCN1A SCN9A SCN10A TRPM1 KCNAB3	5.66e-05	343	124	10	GO:0005261
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYO5A DYNC2H1 MYO1H DNAH14 MYO3B MYO16	9.49e-05	118	124	6	GO:0003774
GeneOntologyMolecularFunction	monoatomic ion channel activity	TRPM6 TRPM7 GRID1 CATSPER3 PKDREJ PIEZO2 SCN1A SCN9A SCN10A TRPM1 KCNAB3	1.38e-04	459	124	11	GO:0005216
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	TRPM6 TRPM7 ANXA5 CATSPER3 SLC30A4 PKDREJ SCN1A SCN9A SCN10A SLC39A6 SLC47A1 TRPM1 KCNAB3 SLC38A3	2.62e-04	758	124	14	GO:0015318
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	TRPM6 TRPM7 ANXA5 CATSPER3 PKDREJ TRPM1	3.63e-04	151	124	6	GO:0015085
GeneOntologyMolecularFunction	channel activity	TRPM6 TRPM7 GRID1 CATSPER3 PKDREJ PIEZO2 SCN1A SCN9A SCN10A TRPM1 KCNAB3	4.35e-04	525	124	11	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	TRPM6 TRPM7 GRID1 CATSPER3 PKDREJ PIEZO2 SCN1A SCN9A SCN10A TRPM1 KCNAB3	4.42e-04	526	124	11	GO:0022803
GeneOntologyMolecularFunction	actin filament binding	MYO5A MYO1H FHOD3 IQGAP1 EGFR FHOD1 MYO16	5.46e-04	227	124	7	GO:0051015
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN1A SCN9A SCN10A	5.47e-04	26	124	3	GO:0005248
GeneOntologyMolecularFunction	calcium channel activity	TRPM6 TRPM7 CATSPER3 PKDREJ TRPM1	1.27e-03	129	124	5	GO:0005262
GeneOntologyMolecularFunction	microfilament motor activity	MYO5A MYO1H MYO3B	1.68e-03	38	124	3	GO:0000146
GeneOntologyMolecularFunction	organic cation transmembrane transporter activity	MFSD12 SLC44A1 SLC47A1 SLC38A3	1.78e-03	83	124	4	GO:0015101
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN1A SCN9A SCN10A	1.34e-04	17	125	3	GO:0001518
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	TSPAN15 EEF1AKMT4-ECE2 ZFYVE16 TRPM7 ANXA5 UBR4 SLC30A4 MFSD12 IQGAP1 TBC1D4 ZFYVE9 IFT88 EGFR NBEAL2 SNX25 TMED2 RMC1 DSE ECE2	2.78e-04	1307	125	19	GO:0030659
GeneOntologyCellularComponent	axon	MYO5A TRPM7 ANXA5 SMURF1 ITGA4 APP TENM2 IQGAP1 ELFN1 SCN1A PRKAA2 SCN9A SCN10A MRGPRX4 TRPM1	2.83e-04	891	125	15	GO:0030424
GeneOntologyCellularComponent	vesicle membrane	TSPAN15 EEF1AKMT4-ECE2 ZFYVE16 TRPM7 ANXA5 UBR4 SLC30A4 MFSD12 IQGAP1 TBC1D4 ZFYVE9 IFT88 EGFR NBEAL2 SNX25 TMED2 RMC1 DSE ECE2	3.30e-04	1325	125	19	GO:0012506
GeneOntologyCellularComponent	myosin complex	MYO5A MYO1H MYO3B MYO16	4.30e-04	59	125	4	GO:0016459
GeneOntologyCellularComponent	manchette	LRGUK IFT88 IQCG	6.13e-04	28	125	3	GO:0002177
GeneOntologyCellularComponent	sodium channel complex	SCN1A SCN9A SCN10A	6.81e-04	29	125	3	GO:0034706
HumanPheno	Photosensitive myoclonic seizure	KCTD7 SCN1A SCN9A	1.63e-05	8	35	3	HP:0001327
HumanPheno	Status epilepticus with prominent motor symptoms	KCTD7 SCN1A SCN9A SLC38A3	3.93e-05	29	35	4	HP:0032658
Domain	IQ_motif_EF-hand-BS	MYO5A IQGAP1 SCN1A MYO3B SCN9A SCN10A MYO16 IQCG	1.39e-07	90	123	8	IPR000048
Domain	IQ	MYO5A IQGAP1 SCN1A MYO3B SCN9A SCN10A MYO16 IQCG	1.79e-07	93	123	8	PS50096
Domain	IQ	MYO5A IQGAP1 SCN1A MYO3B SCN9A SCN10A IQCG	4.24e-07	71	123	7	PF00612
Domain	IQ	MYO5A IQGAP1 SCN1A MYO3B SCN9A MYO16 IQCG	1.05e-06	81	123	7	SM00015
Domain	TRPM_tetra	TRPM6 TRPM7 TRPM1	1.11e-06	4	123	3	PF16519
Domain	TRPM_tetra	TRPM6 TRPM7 TRPM1	1.11e-06	4	123	3	IPR032415
Domain	Ion_trans_dom	TRPM6 TRPM7 CATSPER3 SCN1A SCN9A SCN10A TRPM1	1.04e-05	114	123	7	IPR005821
Domain	Ion_trans	TRPM6 TRPM7 CATSPER3 SCN1A SCN9A SCN10A TRPM1	1.04e-05	114	123	7	PF00520
Domain	Na_channel_asu	SCN1A SCN9A SCN10A	3.23e-05	10	123	3	IPR001696
Domain	Na_trans_assoc	SCN1A SCN9A SCN10A	3.23e-05	10	123	3	IPR010526
Domain	Na_trans_assoc	SCN1A SCN9A SCN10A	3.23e-05	10	123	3	PF06512
Domain	DUF3480	ZFYVE16 ZFYVE9	4.30e-05	2	123	2	PF11979
Domain	DUF3480	ZFYVE16 ZFYVE9	4.30e-05	2	123	2	IPR022557
Domain	Znf_FYVE_endofin	ZFYVE16 ZFYVE9	4.30e-05	2	123	2	IPR017165
Domain	Bcl2-/adenovirus-E1B	BNIP2 BNIPL	2.56e-04	4	123	2	IPR022181
Domain	CSN8_PSD8_EIF3K	COPS2 COPS8	2.56e-04	4	123	2	PF10075
Domain	BNIP2	BNIP2 BNIPL	2.56e-04	4	123	2	PF12496
Domain	TPR_1	TTC28 CNOT10 BBS4 IFIT2 IFT88	3.21e-04	90	123	5	IPR001440
Domain	TPR_1	TTC28 CNOT10 BBS4 IFIT2 IFT88	3.21e-04	90	123	5	PF00515
Domain	TPR_8	TTC28 BBS4 IFIT2 IFT88	4.09e-04	53	123	4	PF13181
Domain	DUF4704	NBEAL1 NBEAL2	4.25e-04	5	123	2	IPR031570
Domain	DUF4704	NBEAL1 NBEAL2	4.25e-04	5	123	2	PF15787
Domain	Alpha_kinase	TRPM6 TRPM7	6.34e-04	6	123	2	PF02816
Domain	Na_trans_cytopl	SCN1A SCN9A	6.34e-04	6	123	2	PF11933
Domain	PH_BEACH	NBEAL1 NBEAL2	6.34e-04	6	123	2	PF14844
Domain	MHCK_EF2_kinase	TRPM6 TRPM7	6.34e-04	6	123	2	IPR004166
Domain	Na_trans_cytopl	SCN1A SCN9A	6.34e-04	6	123	2	IPR024583
Domain	ALPHA_KINASE	TRPM6 TRPM7	6.34e-04	6	123	2	PS51158
Domain	Alpha_kinase	TRPM6 TRPM7	6.34e-04	6	123	2	SM00811
Domain	KA1/Ssp2_C	PRKAA2 MARK2	8.84e-04	7	123	2	IPR028375
Domain	PH-BEACH_dom	NBEAL1 NBEAL2	1.17e-03	8	123	2	IPR023362
Domain	-	NBEAL1 NBEAL2	1.17e-03	8	123	2	2.30.29.40
Domain	PH_BEACH	NBEAL1 NBEAL2	1.17e-03	8	123	2	PS51783
Domain	BEACH	NBEAL1 NBEAL2	1.50e-03	9	123	2	PS50197
Domain	Beach	NBEAL1 NBEAL2	1.50e-03	9	123	2	PF02138
Domain	-	NBEAL1 NBEAL2	1.50e-03	9	123	2	1.10.1540.10
Domain	Beach	NBEAL1 NBEAL2	1.50e-03	9	123	2	SM01026
Domain	BEACH_dom	NBEAL1 NBEAL2	1.50e-03	9	123	2	IPR000409
Domain	TPR	TTC28 CNOT10 BBS4 IFIT2 IFT88	1.64e-03	129	123	5	SM00028
Domain	ARM-type_fold	SMG1 NBEAL1 UBR4 ARFGEF1 FHOD3 NBEAL2 FHOD1 TTI1	1.83e-03	339	123	8	IPR016024
Domain	TPR_repeat	TTC28 CNOT10 BBS4 IFIT2 IFT88	1.88e-03	133	123	5	IPR019734
Domain	Myosin_head_motor_dom	MYO5A MYO3B MYO16	1.99e-03	38	123	3	IPR001609
Domain	MYOSIN_MOTOR	MYO5A MYO3B MYO16	1.99e-03	38	123	3	PS51456
Domain	Myosin_head	MYO5A MYO3B MYO16	1.99e-03	38	123	3	PF00063
Domain	MYSc	MYO5A MYO3B MYO16	1.99e-03	38	123	3	SM00242
Domain	GBD/FH3_dom	FHOD3 FHOD1	2.28e-03	11	123	2	IPR014768
Domain	GBD_FH3	FHOD3 FHOD1	2.28e-03	11	123	2	PS51232
Domain	-	TTC28 CNOT10 BBS4 COPS2 IFIT2 IFT88	2.50e-03	207	123	6	1.25.40.10
Domain	CRAL_TRIO_2	BNIP2 BNIPL	2.72e-03	12	123	2	PF13716
Domain	Dynein_heavy_chain_D4_dom	DYNC2H1 DNAH14	3.72e-03	14	123	2	IPR024317
Domain	Dynein_HC_stalk	DYNC2H1 DNAH14	3.72e-03	14	123	2	IPR024743
Domain	MT	DYNC2H1 DNAH14	3.72e-03	14	123	2	PF12777
Domain	AAA_8	DYNC2H1 DNAH14	3.72e-03	14	123	2	PF12780
Domain	DHC_fam	DYNC2H1 DNAH14	4.27e-03	15	123	2	IPR026983
Domain	FH2	FHOD3 FHOD1	4.27e-03	15	123	2	PS51444
Domain	Dynein_heavy	DYNC2H1 DNAH14	4.27e-03	15	123	2	PF03028
Domain	FH2_Formin	FHOD3 FHOD1	4.27e-03	15	123	2	IPR015425
Domain	FH2	FHOD3 FHOD1	4.27e-03	15	123	2	PF02181
Domain	Dynein_heavy_dom	DYNC2H1 DNAH14	4.27e-03	15	123	2	IPR004273
Domain	FH2	FHOD3 FHOD1	4.27e-03	15	123	2	SM00498
Domain	TPR_2	TTC28 BBS4 IFIT2	4.36e-03	50	123	3	PF07719
Domain	TPR_2	TTC28 BBS4 IFIT2	4.36e-03	50	123	3	IPR013105
Domain	TPR-like_helical_dom	TTC28 CNOT10 BBS4 COPS2 IFIT2 IFT88	4.47e-03	233	123	6	IPR011990
Domain	CarboxyPept-like_regulatory	CPZ TENM2	5.48e-03	17	123	2	IPR008969
Domain	LH2	PNLIPRP1 PKDREJ	6.14e-03	18	123	2	SM00308
Domain	Zn_pept	CPB2 CPZ	6.14e-03	18	123	2	SM00631
Domain	Channel_four-helix_dom	SCN1A SCN9A SCN10A	6.30e-03	57	123	3	IPR027359
Domain	-	SCN1A SCN9A SCN10A	6.30e-03	57	123	3	1.20.120.350
Pubmed	Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.	SCN1A SCN9A SCN10A	1.85e-07	4	126	3	22260870
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN1A SCN9A SCN10A	9.21e-07	6	126	3	23652591
Pubmed	A role for Piezo2 in EPAC1-dependent mechanical allodynia.	PIEZO2 SCN9A SCN10A	1.61e-06	7	126	3	23575686
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	GPM6B DYNC2H1 UBR4 RNF40 SCN10A SLC39A6 MARK2 CDH4 ECE2	2.85e-06	322	126	9	26514267
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN1A SCN9A SCN10A	3.84e-06	9	126	3	16382098
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	TRPM6 TRPM7 PKDREJ TRPM1	6.19e-06	33	126	4	19834762
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	ARFGEF1 APP LIFR TBC1D4 EGFR COPS8 FHOD1 SEC11A DPY19L4 SLC39A6 TTI1 TMED2 UNC93B1 CPVL DSE ALG1	7.49e-06	1201	126	16	35696571
Pubmed	Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons.	TRPM6 TRPM7 TRPM1	9.97e-06	12	126	3	19850157
Pubmed	Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.	UBR4 APP COPS2 COPS8 FBXO21	1.05e-05	79	126	5	27325702
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN1A SCN9A SCN10A	1.29e-05	13	126	3	15123669
Pubmed	Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7.	TRPM6 TRPM7	1.30e-05	2	126	2	16636202
Pubmed	Human endothelin converting enzyme-2 (ECE2): characterization of mRNA species and chromosomal localization.	EEF1AKMT4-ECE2 ECE2	1.30e-05	2	126	2	11718899
Pubmed	Identification of Alzheimer's disease-associated rare coding variants in the ECE2 gene.	APP ECE2	1.30e-05	2	126	2	32102983
Pubmed	TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions.	TRPM6 TRPM7	1.30e-05	2	126	2	24858416
Pubmed	Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women.	TRPM6 TRPM7	1.30e-05	2	126	2	19149903
Pubmed	Massive autophosphorylation of the Ser/Thr-rich domain controls protein kinase activity of TRPM6 and TRPM7.	TRPM6 TRPM7	1.30e-05	2	126	2	18365021
Pubmed	Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia.	TRPM6 TRPM7	1.30e-05	2	126	2	14976260
Pubmed	MAPK scaffold IQGAP1 binds the EGF receptor and modulates its activation.	IQGAP1 EGFR	1.30e-05	2	126	2	21349850
Pubmed	Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia.	TRPM6 TRPM7	1.30e-05	2	126	2	21602712
Pubmed	Identification and characterization of human FHOD3 gene in silico.	FHOD3 FHOD1	1.30e-05	2	126	2	15010865
Pubmed	Differential mRNA expression and glucocorticoid-mediated regulation of TRPM6 and TRPM7 in the heart and kidney throughout murine pregnancy and development.	TRPM6 TRPM7	1.30e-05	2	126	2	25692682
Pubmed	Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease.	IFT88 EGFR	1.30e-05	2	126	2	9486961
Pubmed	MASTL regulates EGFR signaling to impact pancreatic cancer progression.	EGFR MASTL	1.30e-05	2	126	2	34331012
Pubmed	The TRPM6 kinase domain determines the Mg·ATP sensitivity of TRPM7/M6 heteromeric ion channels.	TRPM6 TRPM7	1.30e-05	2	126	2	24385424
Pubmed	Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA.	ZFYVE16 ZFYVE9	1.30e-05	2	126	2	16775010
Pubmed	The channel kinases TRPM6 and TRPM7 are functionally nonredundant.	TRPM6 TRPM7	1.30e-05	2	126	2	16150690
Pubmed	TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg2+ and Mg·ATP.	TRPM6 TRPM7	1.30e-05	2	126	2	28821869
Pubmed	Recent developments in intestinal magnesium absorption.	TRPM6 TRPM7	1.30e-05	2	126	2	18301276
Pubmed	The alpha-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC.	TRPM6 TRPM7	1.30e-05	2	126	2	18675813
Pubmed	Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice.	BBS4 IFT88	1.30e-05	2	126	2	23599282
Pubmed	Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8.	SCN9A SCN10A	1.30e-05	2	126	2	16111501
Pubmed	Mass Spectrometric Analysis of TRPM6 and TRPM7 Phosphorylation Reveals Regulatory Mechanisms of the Channel-Kinases.	TRPM6 TRPM7	1.30e-05	2	126	2	28220887
Pubmed	Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension.	TRPM6 TRPM7	1.30e-05	2	126	2	18192217
Pubmed	IQGAP1 Mediates Hcp1-Promoted Escherichia coli Meningitis by Stimulating the MAPK Pathway.	SMURF1 IQGAP1	1.30e-05	2	126	2	28469997
Pubmed	Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1.	ACO1 APP	1.30e-05	2	126	2	20558735
Pubmed	Fhos2, a novel formin-related actin-organizing protein, probably associates with the nestin intermediate filament.	FHOD3 FHOD1	1.30e-05	2	126	2	15966898
Pubmed	Magnesium homeostasis in colon carcinoma LoVo cells sensitive or resistant to doxorubicin.	TRPM6 TRPM7	1.30e-05	2	126	2	26563869
Pubmed	The Different Roles of The Channel-Kinases TRPM6 and TRPM7.	TRPM6 TRPM7	1.30e-05	2	126	2	26179995
Pubmed	Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis.	TRPM6 TRPM7	1.30e-05	2	126	2	16075242
Pubmed	Evidence for the expression of TRPM6 and TRPM7 in cardiomyocytes from all four chamber walls of the human heart.	TRPM6 TRPM7	1.30e-05	2	126	2	34326388
Pubmed	TRPM6 is Essential for Magnesium Uptake and Epithelial Cell Function in the Colon.	TRPM6 TRPM7	1.30e-05	2	126	2	29912157
Pubmed	Magnesium and its transporters in cancer: a novel paradigm in tumour development.	TRPM6 TRPM7	1.30e-05	2	126	2	22671428
Pubmed	Gene variation of the transient receptor potential cation channel, subfamily M, members 6 (TRPM6) and 7 (TRPM7), and type 2 diabetes mellitus: a case-control study.	TRPM6 TRPM7	1.30e-05	2	126	2	20875900
Pubmed	Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease.	ACO1 APP	1.30e-05	2	126	2	23935819
Pubmed	Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.	GPM6B FLVCR1 RALGAPB SLC44A1 SCN1A SCN9A SLC39A6 MARK2 SLC38A3	1.79e-05	405	126	9	38187761
Pubmed	Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.	TRPM6 TRPM7 PKDREJ TRPM1	1.99e-05	44	126	4	19322198
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	SMG1 ANXA5 UBR4 IQGAP1 PHKB TBC1D4 PDCD5 MARK2 FBXO21 CPVL VAT1	2.23e-05	639	126	11	23443559
Pubmed	Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set.	NBEAL1 RALGAPB CIDEA PIEZO2 EGFR DLAT	2.42e-05	157	126	6	12466305
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	FLVCR1 RALGAPB ITGA4 APP ZFYVE9 EGFR SLC39A6 MARK2 VAT1	2.42e-05	421	126	9	36976175
Pubmed	The cell and molecular basis of mechanical, cold, and inflammatory pain.	SCN9A SCN10A	3.90e-05	3	126	2	18669863
Pubmed	Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).	SCN1A SCN9A	3.90e-05	3	126	2	33895391
Pubmed	Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination.	LIFR EGFR	3.90e-05	3	126	2	15385618
Pubmed	Sodium channels and mammalian sensory mechanotransduction.	SCN9A SCN10A	3.90e-05	3	126	2	22449024
Pubmed	Dissociation of epidermal growth factor receptor and ErbB2 heterodimers in the presence of somatostatin receptor 5 modulate signaling pathways.	SSTR5 EGFR	3.90e-05	3	126	2	21190959
Pubmed	Sodium channel Na(v)1.7 is essential for lowering heat pain threshold after burn injury.	SCN9A SCN10A	3.90e-05	3	126	2	22875917
Pubmed	Fhod1, an actin-organizing formin family protein, is dispensable for cardiac development and function in mice.	FHOD3 FHOD1	3.90e-05	3	126	2	31008549
Pubmed	N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation.	TRPM6 TRPM7	3.90e-05	3	126	2	25277194
Pubmed	Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis.	PIEZO2 SCN10A	3.90e-05	3	126	2	37120427
Pubmed	Genetic Analysis of SCN11A, SCN10A, and SCN9A in Familial Episodic Pain Syndrome (FEPS) in Japan and Proposal of Clinical Diagnostic Criteria.	SCN9A SCN10A	3.90e-05	3	126	2	38999942
Pubmed	LIV-1 promotes prostate cancer epithelial-to-mesenchymal transition and metastasis through HB-EGF shedding and EGFR-mediated ERK signaling.	EGFR SLC39A6	3.90e-05	3	126	2	22110740
Pubmed	The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence.	BNIP2 BNIPL	3.90e-05	3	126	2	11741952
Pubmed	Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme.	APP ECE2	3.90e-05	3	126	2	12464614
Pubmed	5'-AMP-activated protein kinase alpha regulates stress granule biogenesis.	G3BP1 PRKAA2	3.90e-05	3	126	2	25840010
Pubmed	Role of somatostatin receptor 1 and 5 on epidermal growth factor receptor mediated signaling.	SSTR5 EGFR	3.90e-05	3	126	2	21419811
Pubmed	Somatostatin receptors 1 and 5 heterodimerize with epidermal growth factor receptor: agonist-dependent modulation of the downstream MAPK signalling pathway in breast cancer cells.	SSTR5 EGFR	3.90e-05	3	126	2	19070659
Pubmed	Identification of the amyloid β-protein precursor and cystatin C as novel epidermal growth factor receptor regulated secretory proteins in nasopharyngeal carcinoma by proteomics.	APP EGFR	3.90e-05	3	126	2	20882990
Pubmed	Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.	SCN9A SCN10A	3.90e-05	3	126	2	19699781
Pubmed	Genetic architecture of human thinness compared to severe obesity.	PKHD1 PRDM6	3.90e-05	3	126	2	30677029
Pubmed	A novel dynein light intermediate chain colocalizes with the retrograde motor for intraflagellar transport at sites of axoneme assembly in chlamydomonas and Mammalian cells.	DYNC2H1 IFT88	3.90e-05	3	126	2	12802074
Pubmed	Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Nav1.7 knockout mice.	SCN9A SCN10A	3.90e-05	3	126	2	28074005
Pubmed	COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.	COPS2 COPS8	3.90e-05	3	126	2	17906629
Pubmed	Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain.	SCN9A SCN10A	3.90e-05	3	126	2	15314237
Pubmed	TRPV6, TRPM6 and TRPM7 Do Not Contribute to Hair-Cell Mechanotransduction.	TRPM6 TRPM7	3.90e-05	3	126	2	29515374
Pubmed	EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer.	LIFR EGFR	3.90e-05	3	126	2	32963351
Pubmed	Yield of peripheral sodium channels gene screening in pure small fibre neuropathy.	SCN9A SCN10A	3.90e-05	3	126	2	30554136
Pubmed	AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits.	TBC1D4 PRKAA2	3.90e-05	3	126	2	16804075
Pubmed	The N-recognin UBR4 of the N-end rule pathway is required for neurogenesis and homeostasis of cell surface proteins.	UBR4 EGFR	3.90e-05	3	126	2	30157281
Pubmed	C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway.	PIEZO2 SCN10A MRGPRX4	4.31e-05	19	126	3	38915692
Pubmed	ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons.	SCN9A SCN10A MRGPRX4	5.89e-05	21	126	3	25369838
Pubmed	Evolution and diversity of mammalian sodium channel genes.	SCN9A SCN10A	7.78e-05	4	126	2	10198179
Pubmed	Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes.	MYO5A TBC1D4	7.78e-05	4	126	2	22908308
Pubmed	Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling.	BBS4 IFT88	7.78e-05	4	126	2	33200981
Pubmed	Piezo2 regulates colonic mechanical sensitivity in a sex specific manner in mice.	PIEZO2 SCN10A	7.78e-05	4	126	2	37061508
Pubmed	Analgesic targets identified in mouse sensory neuron somata and terminal pain translatomes.	SCN9A SCN10A	7.78e-05	4	126	2	39163201
Pubmed	What are those cilia doing in the neural tube?	DYNC2H1 IFT88	7.78e-05	4	126	2	23351466
Pubmed	Nedd4-2 haploinsufficiency causes hyperactivity and increased sensitivity to inflammatory stimuli.	SCN9A SCN10A	7.78e-05	4	126	2	27604420
Pubmed	Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons.	SCN9A SCN10A	7.78e-05	4	126	2	22531176
Pubmed	Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis.	SCN9A SCN10A	7.78e-05	4	126	2	38172636
Pubmed	Lack of metformin effect on mouse embryo AMPK activity: implications for metformin treatment during pregnancy.	PRKAA2 SLC47A1	7.78e-05	4	126	2	23983188
Pubmed	Reversal of ciliary mechanisms of disassembly rescues olfactory dysfunction in ciliopathies.	BBS4 IFT88	7.78e-05	4	126	2	35771640
Pubmed	Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome.	COPS2 COPS8	7.78e-05	4	126	2	10991940
Pubmed	An initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, COP1.	COPS2 COPS8	7.78e-05	4	126	2	12466024
Pubmed	BBS4 is required for intraflagellar transport coordination and basal body number in mammalian olfactory cilia.	BBS4 IFT88	7.78e-05	4	126	2	30665891
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	DYNC2H1 ACO1 ANXA5 SMURF1 GRID1 IQGAP1 SLC44A1 COPS8 SCN10A PKHD1 CPVL VAT1 IQCG	8.51e-05	1016	126	13	19056867
Pubmed	Mapping the expression of transient receptor potential channels across murine placental development.	TRPM6 TRPM7 TRPM1	8.89e-05	24	126	3	33884443
Pubmed	International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.	TRPM6 TRPM7 TRPM1	1.01e-04	25	126	3	16382100
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	MYO5A ZFYVE16 FLVCR1 RALGAPB APP PHKB TBC1D4 ZFYVE9 EGFR SLC39A6 TTI1 CPVL VAT1	1.17e-04	1049	126	13	27880917
Pubmed	Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules.	CPB2 ITGA4 GREB1 CDH4	1.18e-04	69	126	4	21491542
Pubmed	Deletion of Pdcd5 in mice led to the deficiency of placenta development and embryonic lethality.	EGFR PDCD5 PRKAA2	1.27e-04	27	126	3	28542142
Pubmed	An introduction to TRP channels.	TRPM6 TRPM7 TRPM1	1.27e-04	27	126	3	16460286
Interaction	LAMP1 interactions	MYO5A ZFYVE16 TRPM7 FLVCR1 UBR4 RALGAPB SLC30A4 TENM2 IQGAP1 ZFYVE9 G3BP1 EGFR SEC11A SLC39A6 MARK2 VAT1	1.95e-06	644	123	16	int:LAMP1
Interaction	TM2D1 interactions	APP EGFR DPY19L4	1.21e-05	8	123	3	int:TM2D1
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN1A SCN9A SCN10A	5.89e-06	9	76	3	1203
GeneFamily	Carboxypeptidases	CPB2 CPZ CPVL	8.99e-05	21	76	3	1321
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	TTC28 CNOT10 BBS4 IFIT2 IFT88	1.23e-04	115	76	5	769
GeneFamily	Transient receptor potential cation channels	TRPM6 TRPM7 TRPM1	2.17e-04	28	76	3	249
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	BNIP2 BNIPL	3.61e-04	7	76	2	1299
GeneFamily	COP9 signalosome	COPS2 COPS8	6.16e-04	9	76	2	932
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEAL1 NBEAL2	6.16e-04	9	76	2	1230
GeneFamily	Solute carriers	FLVCR1 SLC30A4 SLC44A1 SLC39A6 SLC47A1 SLC38A3	6.33e-03	395	76	6	752
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	ZFYVE16 ZFYVE9	7.49e-03	31	76	2	81
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPM6B GRID1 FHOD3 CPED1 PIEZO2 ABCA6 PRDM6 MYO16	4.72e-08	180	126	8	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPM6B GRID1 FHOD3 CPED1 PIEZO2 ABCA6 PRDM6 MYO16	4.72e-08	180	126	8	9b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPM6B GRID1 FHOD3 CPED1 PIEZO2 ABCA6 PRDM6 MYO16	4.92e-08	181	126	8	9e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	TRPM7 FHOD3 CPED1 TENM2 TBC1D4 PRKAA2 AIG1 CPVL	6.60e-08	188	126	8	0758b474457efa36488e0195f7357100f4b6a090
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	TTC28 TENM2 LIFR PIEZO2 ABCA6 EGFR CDH4 PRDM6	8.41e-08	194	126	8	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	facs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYNC2H1 NUP210L LRGUK SLC44A1 TBC1D4 MYO3B ANKRD24	5.62e-07	170	126	7	d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CPED1 SCN9A SLC47A1 GREB1 KCNAB3 MYO16 ECE2	1.10e-06	188	126	7	8de5a07301f9b5984680c873e5a92395b5ed3dd3
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CPED1 ELFN1 SCN9A SLC47A1 GREB1 KCNAB3 MYO16	1.32e-06	193	126	7	4979862c0c16e6b4baa4c79894f1d237c861f5a5
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	TTC28 TENM2 LIFR PIEZO2 ABCA6 EGFR PRDM6	1.41e-06	195	126	7	0e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPM6B GRID1 CPZ ABCA6 PRDM6 MYO16	1.53e-06	125	126	6	b162a5bfbb8ac5e65e13578fef9de442a9e4fd8b
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Calb2_Necab1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NLRX1 IFIT2 TBC1D4 ELFN1 CDH4 ECE2	1.60e-06	126	126	6	a4fc7ac4931d2fc8aa8196a62d809b698937aa9c
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_only / Treatment groups by lineage, cell group, cell type	GPM6B TTC28 DYNC2H1 REV3L LIFR ABCA6 MYO16	1.67e-06	200	126	7	a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FHOD3 PKDREJ TENM2 SCN9A SCN10A ELOVL3	5.93e-06	158	126	6	f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FHOD3 PKDREJ TENM2 SCN9A SCN10A ELOVL3	5.93e-06	158	126	6	8c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCell	droplet-Liver-HEPATOCYTES-1m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCTD7 TSPAN15 GPM6B MYO1H SNX25 DSE	6.38e-06	160	126	6	a494001b1f6dec33624f98fa3c24bad6988d0425
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM6 TRPM7 DYNC2H1 ELFN1 PKHD1 MYO16	1.13e-05	177	126	6	c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CPED1 PIEZO2 SCN9A GREB1 KCNAB3 MYO16	1.21e-05	179	126	6	d1365d48d1b017a7917f4f63a82ac4720c3d87df
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMCO1 FLVCR1 ITGA4 CPED1 FHOD1 PRKAA2	1.21e-05	179	126	6	f99500c4a590e5152ded5862690f7fa614d64a80
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMCO1 FLVCR1 ITGA4 CPED1 FHOD1 PRKAA2	1.21e-05	179	126	6	7d61466181ab73088de3ec8a129d7cfa8cac7ecc
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DYNC2H1 GRID1 FHOD3 PIEZO2 EGFR PRDM6	1.21e-05	179	126	6	a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMCO1 FLVCR1 ITGA4 CPED1 FHOD1 PRKAA2	1.21e-05	179	126	6	6c98ce32cb55cf9cee557449e41b23bdb22f5efd
ToppCell	LV\|World / Chamber and Cluster_Paper	TRPM7 FHOD3 TENM2 TBC1D4 AIG1 CPVL	1.25e-05	180	126	6	5ac6f485a58bb29462fec02dfbe8eb70864eafe3
ToppCell	RV\|World / Chamber and Cluster_Paper	TRPM7 FHOD3 TENM2 TBC1D4 PRKAA2 AIG1	1.29e-05	181	126	6	bbe1e6e59d8889bd37d6e8303116cbdcafca7236
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CPED1 PIEZO2 SCN9A SLC47A1 GREB1 KCNAB3	1.37e-05	183	126	6	5a541a7f6c3514be8a13e988185dfe388c874f8b
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	TTC28 MYO5A REV3L ITGA4 ABCA6 GREB1	1.41e-05	184	126	6	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	TRPM7 FHOD3 CPED1 TENM2 TBC1D4 PRKAA2	1.46e-05	185	126	6	6baccb26f999145e51b91d94315bf8d4655bef31
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-plasmacytoid_dendritic_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	GPM6B APP TDRD1 ABCA6 SCN9A UNC93B1	1.50e-05	186	126	6	a07694caf7fede06a47636725bcc7f09909cdf07
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CPED1 PIEZO2 SCN9A SLC47A1 KCNAB3 MYO16	1.55e-05	187	126	6	d413fb4b1531b297af5012a392b88128510c2de8
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	TRPM7 FHOD3 TENM2 TBC1D4 PRKAA2 AIG1	1.55e-05	187	126	6	78cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-plasmacytoid_dendritic_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	GPM6B APP TDRD1 ABCA6 SCN9A UNC93B1	1.60e-05	188	126	6	26405ef1b934744e672c642db78834c21d3ba28f
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|RV / Chamber and Cluster_Paper	TRPM7 FHOD3 TENM2 TBC1D4 PRKAA2 AIG1	1.65e-05	189	126	6	9c1debd65c13d63fd4f3158917d621b44b714c26
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPM6B CPZ PIEZO2 ABCA6 PRDM6 MYO16	1.65e-05	189	126	6	a153b83314cf52808f685296cff8c95af3f4983d
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ELFN1 SCN9A SLC47A1 GREB1 KCNAB3 ECE2	1.70e-05	190	126	6	26843ec1d19ac85a50990705353b802745d33e4d
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	TRPM7 FHOD3 TENM2 TBC1D4 PRKAA2 CPVL	1.70e-05	190	126	6	de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CPED1 SCN9A SLC47A1 GREB1 KCNAB3 MYO16	1.70e-05	190	126	6	3f22c118d552345f731d4d49f0bcb5765d93de3b
ToppCell	PCW_13-14\|World / Celltypes from embryonic and fetal-stage human lung	LIFR SLC44A1 PIEZO2 ABCA6 CDH4 PRDM6	1.70e-05	190	126	6	62a3ec1ae0829602b0569cc051210551644f1d46
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPM6B GRID1 FHOD3 CPED1 PRDM6 MYO16	1.75e-05	191	126	6	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	10x3'2.3-week_17-19-Myeloid_DC-DC-pDC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	GPM6B APP CPED1 ABCA6 SCN9A UNC93B1	1.75e-05	191	126	6	faf4de97003a938a243b0101456913c2b0e1804f
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	TRPM7 FHOD3 CPED1 TENM2 TBC1D4 PRKAA2	1.80e-05	192	126	6	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	LPS_only-Stromal_mesenchymal\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TTC28 CPZ CPED1 PIEZO2 PRDM6 MYO16	1.80e-05	192	126	6	162d8b5858d150ecbbd1c9bf2b19c6c9cd50a158
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPM6B CPED1 PIEZO2 ABCA6 PRDM6 MYO16	1.80e-05	192	126	6	3d0cb19f037f604253d7d728689aeaa94251e92b
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EGFR ELFN1 SLC47A1 KCNAB3 MYO16 ECE2	1.80e-05	192	126	6	bf1943715085c4124b1675888b0615c9500ec888
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CPED1 ELFN1 SCN9A SLC47A1 KCNAB3 ECE2	1.85e-05	193	126	6	53bcd50892c379b2a571751f6eb1062436339fe7
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPM6B CPED1 PIEZO2 ABCA6 PRDM6 MYO16	1.85e-05	193	126	6	fb28717fadd06c3840636d25409ce80c9254bd34
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FHOD3 DNAH14 PRKAA2 AIG1 PKHD1 SLC47A1	1.85e-05	193	126	6	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CPED1 ELFN1 SCN9A SLC47A1 KCNAB3 ECE2	1.85e-05	193	126	6	5581a5ebcd21a2a8062ccfb917f088ec67a10a9c
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TTC28 TENM2 LIFR PIEZO2 ABCA6 PRDM6	1.91e-05	194	126	6	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FHOD3 DNAH14 MYO3B PRKAA2 AIG1 PKHD1	1.91e-05	194	126	6	5eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EGFR ELFN1 SLC47A1 KCNAB3 MYO16 ECE2	1.91e-05	194	126	6	02a9cc821c2b14aa7d0e55661a5fab66364474e1
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	FHOD3 CPED1 TENM2 TBC1D4 PRKAA2 CPVL	1.96e-05	195	126	6	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	TENM2 LIFR PIEZO2 ABCA6 CDH4 PRDM6	1.96e-05	195	126	6	1cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FHOD3 DNAH14 MYO3B PRKAA2 AIG1 PKHD1	1.96e-05	195	126	6	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	Epithelial-Epithelial-A_(AT1)\|Epithelial / shred on cell class and cell subclass (v4)	TSPAN15 ANXA5 APP CPED1 IFIT2 DENND3	2.02e-05	196	126	6	41b21a18125cc95bc8adde3369e4abd029cf137d
ToppCell	AT2_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	CPB2 LIFR SLC44A1 EGFR SNX25 SCN1A	2.14e-05	198	126	6	893036558a9ad86b57f9e735df35812e9d18739e
ToppCell	Sepsis-ICU-SEP-Myeloid-pDC\|ICU-SEP / Disease, condition lineage and cell class	GPM6B APP CPED1 ABCA6 SCN9A UNC93B1	2.14e-05	198	126	6	fe8a68bff8c1b9566eee4bfcab564f206a20ae7b
ToppCell	Sepsis-Leuk-UTI-Others\|Leuk-UTI / Disease, condition lineage and cell class	GPM6B APP TBC1D4 SCN9A TMED2 UNC93B1	2.20e-05	199	126	6	e45fe91f1d1c47a305b0f39d808730723852af00
ToppCell	Sepsis-Leuk-UTI-Others-RBC\|Leuk-UTI / Disease, condition lineage and cell class	GPM6B APP TBC1D4 SCN9A TMED2 UNC93B1	2.20e-05	199	126	6	d9b517199a646c9461c615412ad5b58cf4bed7c8
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	NBEAL1 DENND3 EGFR NBEAL2 FHOD1 PKHD1	2.20e-05	199	126	6	d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	GPM6B DYNC2H1 CPED1 LIFR ABCA6 MYO16	2.20e-05	199	126	6	30d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCell	wk_15-18-Mesenchymal-Fibroblast-Alveolar_fibro\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	LIFR SLC44A1 PIEZO2 ABCA6 FHOD1 PRDM6	2.20e-05	199	126	6	6bce8e65859a35cfea1c210f9c9765952d492ed2
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	GPM6B DYNC2H1 REV3L LIFR ABCA6 MYO16	2.26e-05	200	126	6	9b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-MIR548F2--L5-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CPED1 PIEZO2 SCN9A SLC47A1 KCNAB3 MYO16	2.26e-05	200	126	6	3cbb01039d1e7635ec4dcdf0223587f7ea3c7b34
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-MEPE-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CPED1 MYO3B SCN9A SLC47A1 GREB1 KCNAB3	2.26e-05	200	126	6	d4161fcbbe47236aac4a077c0994887e765b0b47
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1--L4-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CPED1 PIEZO2 MYO3B SCN9A KCNAB3 MYO16	2.26e-05	200	126	6	4a426ef88376d8bb2b9dc50aa06e7b9fc50ecc9c
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-MIR548F2-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CPED1 PIEZO2 SCN9A SLC47A1 KCNAB3 MYO16	2.26e-05	200	126	6	97a010a1b6d551239cf6ea5a43319fb413ff180e
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-MEPE\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CPED1 MYO3B SCN9A SLC47A1 GREB1 KCNAB3	2.26e-05	200	126	6	0d0c69758370d3c44ffe6640e332b6118fc5ce58
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-MIR548F2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CPED1 PIEZO2 SCN9A SLC47A1 KCNAB3 MYO16	2.26e-05	200	126	6	8ccf2dbbe34b26fbf2bbef1e64b4ae636edd6672
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-MEPE--L4-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CPED1 MYO3B SCN9A SLC47A1 GREB1 KCNAB3	2.26e-05	200	126	6	c546fa80876640bd57a5252df611977009bef9e8
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CPED1 PIEZO2 SCN9A SLC47A1 KCNAB3 ECE2	2.26e-05	200	126	6	107854f4855fc99c9f7e737eb246f0d868e6c5fd
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CPED1 PIEZO2 MYO3B SCN9A KCNAB3 MYO16	2.26e-05	200	126	6	fbeee1c16ac0a7fe28d90491c8b079f21ce80bdc
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CPED1 PIEZO2 MYO3B SCN9A KCNAB3 MYO16	2.26e-05	200	126	6	c6eda342ea0cb37d71d89dbb8d11e819e0745172
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-NK_CD56bright\|ICU-NoSEP / Disease, condition lineage and cell class	ZNF577 TTC28 ZNF485 DNAH14 SLC44A1 KCNAB3	2.26e-05	200	126	6	c2df917900872453ea17a39928e39d071a6d3339
ToppCell	Neuronal-Inhibitory-iB\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CPED1 ELFN1 SCN9A SLC47A1 KCNAB3 ECE2	2.26e-05	200	126	6	45ddc5ef2caa87ada88327b63ba9b150a6bb3aa5
ToppCell	Entopeduncular-Macroglia-OLIGODENDROCYTE-O1-Trf\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SMCO1 DNAH14 ABCA6 TRPM1	6.44e-05	76	126	4	efbbbf91bca35720d8ecddb076f2c9f4de25e44d
ToppCell	Entopeduncular-Macroglia-OLIGODENDROCYTE-O1\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SMCO1 DNAH14 ABCA6 TRPM1	6.44e-05	76	126	4	254d18bece2676faa4bbeb8d48b1d327ab3c2215
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TRPM6 CPZ PKHD1 SLC47A1 PRDM6	7.47e-05	153	126	5	151c469b26f9adf04dd6f117f03bef760cc3d45d
ToppCell	facs-Liver-Hepatocytes\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACO1 ABCA6 EGFR SLC47A1 SLC38A3	8.19e-05	156	126	5	e2cda3ad4e5f44a80133864c5a38b766afb952ce
ToppCell	droplet-Liver-HEPATOCYTES-1m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCTD7 TSPAN15 GPM6B MYO1H SNX25	8.44e-05	157	126	5	b527e88382c8d21188a0f222b3302523e8816dfc
ToppCell	facs-Heart-RV-24m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRGUK ELFN1 SCN10A PKHD1 TRPM1	9.22e-05	160	126	5	41d6c811c445c0ba9b6a2deb10a3b6b793172582
ToppCell	facs-Heart-RV-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRGUK ELFN1 SCN10A PKHD1 TRPM1	9.22e-05	160	126	5	c1d03c0ac9c12615a06499209fcdf18e9b6f1fba
ToppCell	droplet-Lung-3m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l15\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYO5A ZFYVE16 FLVCR1 SLC30A4 DENND3	1.07e-04	165	126	5	1d0f60bf47a40ac916f0fcb5532a968742a0edbb
ToppCell	ICU-NoSEP-Lymphocyte-T_NK-NK_CD56bright\|ICU-NoSEP / Disease, Lineage and Cell Type	TTC28 ZNF485 DNAH14 SLC44A1 KCNAB3	1.13e-04	167	126	5	f4f188a8efca8cdd0ecfb857fe4538c10847eadd
ToppCell	facs-Thymus-nan-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO5A LRRC74A ITGA4 UNC93B1 DSE	1.16e-04	168	126	5	d72cd8238fa793bb3e4add4c59eaaaadcea9930d
ToppCell	facs-Thymus-nan-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO5A LRRC74A ITGA4 UNC93B1 DSE	1.16e-04	168	126	5	c34c52165485f612add7a3e35a175d5a6e365e7c
ToppCell	facs-Thymus-nan-3m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO5A LRRC74A ITGA4 UNC93B1 DSE	1.16e-04	168	126	5	d2afc097ae1243574210be6a751685f949ea941a
ToppCell	COVID-19-Heart-CM_+_Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FHOD3 CPED1 TENM2 PRKAA2 CPVL	1.23e-04	170	126	5	3f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCell	COVID-19-Heart-CM_+_Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	MYO5A FHOD3 TENM2 PRKAA2 CPVL	1.23e-04	170	126	5	4232fe937909f93d3736988c707b8f95ce993398
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM6 TRPM7 ABCA6 MYO3B PKHD1	1.33e-04	173	126	5	0c74bdb40e635d906fd180412c23bf7fed61621e
ToppCell	5'-Adult-Distal_Rectal-Hematopoietic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MFSD12 DENND3 ZMIZ2 SCN9A CPVL	1.33e-04	173	126	5	b335ca2a247156eba821943b2b9fc9922230b409
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CPED1 SCN9A KCNAB3 MYO16 ECE2	1.33e-04	173	126	5	61907116a1460bc157ba73b5edd108db7dd5de4b
ToppCell	droplet-Liver-Npc-18m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKRD35 BBS4 IQGAP1 TMEM268 UNC93B1	1.33e-04	173	126	5	9ba55e21d1037ec3150d77895e52f0b051df65da
ToppCell	BAL-Mild-Epithelial-Epithelial-AT1/AT2-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FHOD3 LRGUK EGFR SCN9A SLC38A3	1.37e-04	174	126	5	71730503be3d9c839c4c9e950145e2101d682a1c
ToppCell	BAL-Mild-Epithelial-Epithelial-AT1/AT2\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	FHOD3 LRGUK EGFR SCN9A SLC38A3	1.37e-04	174	126	5	ee8ac51fa0b426ad7b7453371bb79c8bf8c1d358
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage_4\|356C / Donor, Lineage, Cell class and subclass (all cells)	ANXA5 TDRD1 PIEZO2 CPVL VAT1	1.37e-04	174	126	5	75b3a852140fb726025c3c987143d67944afde2d
ToppCell	NS-critical-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TSPAN15 DYNC2H1 JAKMIP3 LRGUK PRKAA2	1.44e-04	176	126	5	b794275fdd757b8fa2108e3c867f23da2649146d
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CPED1 ELFN1 SCN9A KCNAB3 MYO16	1.44e-04	176	126	5	95d5a4fdff1b9c715636684d22e06f8727ac0e7a
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CPED1 PIEZO2 SCN9A KCNAB3 MYO16	1.44e-04	176	126	5	682a1dfcc507ec540f5fadf08e872533ea9f0291
ToppCell	LPS-IL1RA+antiTNF\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LIFR SLC44A1 TBC1D4 PRDM6 MYO16	1.48e-04	177	126	5	b7fee75de7e96924af488a5baa2334711889ae7c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TBC1D4 EGFR PKHD1 CPVL CDH4	1.48e-04	177	126	5	da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GPM6B LRGUK SCN1A SCN9A CDH4	1.48e-04	177	126	5	d05497d2c80a66ec6a4e1733fea3a5534877a6a7
Drug	Lidocaine	EGFR SCN9A SCN10A	6.28e-07	4	124	3	DB00281
Disease	Autosomal Recessive Polycystic Kidney Disease	IFT88 EGFR PKHD1	6.12e-06	9	125	3	C0085548
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN1A SCN9A SCN10A	8.71e-06	10	125	3	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN1A SCN9A SCN10A	8.71e-06	10	125	3	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN1A SCN9A SCN10A	1.59e-05	12	125	3	DOID:0060170 (implicated_via_orthology)
Disease	Early Infantile Epileptic Encephalopathy 6	SCN1A SCN9A	1.78e-05	2	125	2	C4551549
Disease	Primary Erythermalgia	SCN9A SCN10A	5.33e-05	3	125	2	C0014805
Disease	PAROXYSMAL EXTREME PAIN DISORDER	SCN9A SCN10A	5.33e-05	3	125	2	C1833661
Disease	Ovarian cyst	TTC28 GREB1	1.77e-04	5	125	2	HP_0000138
Disease	urate measurement, bone density	TRPM6 TTC28 UGT1A6 GRID1 CATSPER3 TENM2 DNAH14 CDH4 SLC38A3 MYO16	3.14e-04	619	125	10	EFO_0003923, EFO_0004531
Disease	Congenital Pain Insensitivity	SCN9A SCN10A	3.69e-04	7	125	2	C0002768
Disease	Hereditary Sensory Autonomic Neuropathy, Type 5	SCN9A SCN10A	3.69e-04	7	125	2	C0020075
Disease	MASA syndrome (implicated_via_orthology)	TRPM7 TRPM1	3.69e-04	7	125	2	DOID:0060246 (implicated_via_orthology)
Disease	plasma betaine measurement	PDCD5 ELOVL3 MYO16	4.03e-04	34	125	3	EFO_0007787
Disease	Early Childhood Epilepsy, Myoclonic	SCN1A SCN9A	4.90e-04	8	125	2	C0393695
Disease	Idiopathic Myoclonic Epilepsy	SCN1A SCN9A	4.90e-04	8	125	2	C0338478
Disease	Symptomatic Myoclonic Epilepsy	SCN1A SCN9A	4.90e-04	8	125	2	C0338479
Disease	Benign Infantile Myoclonic Epilepsy	SCN1A SCN9A	4.90e-04	8	125	2	C0751120
Disease	Myoclonic Encephalopathy	SCN1A SCN9A	4.90e-04	8	125	2	C0438414
Disease	Myoclonic Absence Epilepsy	SCN1A SCN9A	4.90e-04	8	125	2	C0393703
Disease	Todd Paralysis	TRPM7 APP	6.29e-04	9	125	2	C0234544
Disease	Paralysed	TRPM7 APP	6.29e-04	9	125	2	C0522224
Disease	Myoclonic Epilepsy	SCN1A SCN9A	6.29e-04	9	125	2	C0014550
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN1A SCN9A	6.29e-04	9	125	2	C3502809
Disease	Epilepsy, Myoclonic, Infantile	SCN1A SCN9A	7.84e-04	10	125	2	C0917800
Disease	Weight Gain	ANXA5 APP IQGAP1 FBXO21	9.47e-04	102	125	4	C0043094
Disease	Myoclonic Astatic Epilepsy	SCN1A SCN9A	9.55e-04	11	125	2	C0393702
Disease	dental caries	PHTF2 GRID1 PIEZO2 SCN9A MYO16	1.23e-03	187	125	5	EFO_0003819
Disease	Hypoxanthine measurement	TSPAN15 PKHD1	1.35e-03	13	125	2	EFO_0021604
Disease	Infantile Severe Myoclonic Epilepsy	SCN1A SCN9A	1.35e-03	13	125	2	C0751122
Disease	neuroblastoma	GRID1 CPZ TENM2 GREB1	1.52e-03	116	125	4	EFO_0000621
Disease	quinate measurement	GRID1 OR13D1	1.80e-03	15	125	2	EFO_0021167
Disease	urate measurement, spine bone mineral density	UGT1A6 EGFR PRDM6	1.93e-03	58	125	3	EFO_0004531, EFO_0007701
Disease	Neuralgia, Supraorbital	SCN9A SCN10A	2.05e-03	16	125	2	C0038870
Disease	Neuralgia	SCN9A SCN10A	2.05e-03	16	125	2	C0027796
Disease	Neuralgia, Atypical	SCN9A SCN10A	2.05e-03	16	125	2	C0234247
Disease	Neuralgia, Stump	SCN9A SCN10A	2.05e-03	16	125	2	C0234249
Disease	Neuralgia, Iliohypogastric Nerve	SCN9A SCN10A	2.05e-03	16	125	2	C0423712
Disease	Neuralgia, Perineal	SCN9A SCN10A	2.05e-03	16	125	2	C0423711
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	IFT88 PKHD1	2.05e-03	16	125	2	DOID:0110861 (implicated_via_orthology)
Disease	Paroxysmal Nerve Pain	SCN9A SCN10A	2.05e-03	16	125	2	C0751373
Disease	Nerve Pain	SCN9A SCN10A	2.05e-03	16	125	2	C0751372
Disease	Neuralgia, Ilioinguinal	SCN9A SCN10A	2.05e-03	16	125	2	C0751371
Disease	Neuralgia, Vidian	SCN9A SCN10A	2.05e-03	16	125	2	C0042656
Disease	renal agenesis, unilateral	ZNF485 COPS2 TBC1D4	2.23e-03	61	125	3	MONDO_0019636
Disease	esophageal carcinoma, gastric carcinoma	ATG2B TRPM1	2.32e-03	17	125	2	EFO_0000178, EFO_0002916
Disease	p-tau:beta-amyloid 1-42 ratio measurement	TTC28 PRDM6	2.90e-03	19	125	2	EFO_0007709
Disease	ascending aortic diameter	PIEZO2 COPS8 AIG1 PRDM6	3.02e-03	140	125	4	EFO_0021787
Disease	brain age measurement	EEF1AKMT4-ECE2 ECE2	3.22e-03	20	125	2	EFO_0010602
Disease	smoking behavior	GRID1 REV3L TENM2 ELFN1 PKHD1 SLC38A3	3.38e-03	341	125	6	EFO_0004318
Disease	bone density, lean body mass	CPED1 ZBTB40	3.55e-03	21	125	2	EFO_0003923, EFO_0004995
Disease	Infiltrating duct carcinoma of female breast	SMG1 TRPM7	3.55e-03	21	125	2	C3165106
Disease	bipolar disorder, body mass index	ZNF577 PKHD1 CDH4	3.58e-03	72	125	3	EFO_0004340, MONDO_0004985
Disease	anxiety disorder (implicated_via_orthology)	SCN1A SCN9A	3.89e-03	22	125	2	DOID:2030 (implicated_via_orthology)
Disease	body weight loss	PKHD1 CDH4	3.89e-03	22	125	2	EFO_0005245

Protein segments in the cluster

Peptide	Gene	Start	Entry
VQLYSSEVLEYMNQL	TDRD1	281	Q9BXT4
LTYFLNGGILNYMIR	ACO1	871	P21399
MEYLLNQNGLIYLGT	EPB42	156	P16452
GEYRMLQAQFSLLYN	RNF40	386	O75150
ILYNLGLVHLTMQQY	BBS4	306	Q96RK4
YLYLQANLIEVVMAS	ELFN1	136	P0C7U0
LMNFLYLLGEVLNNY	AIG1	206	Q9NVV5
FQYGVKVVLQAMYLL	ALG1	101	Q9BT22
LRQLMGKQFTYLYIA	CATSPER3	131	Q86XQ3
GTQLLEIYALEIQMY	COPS2	191	P61201
GIMYYLIERLNETLQ	CPED1	781	A4D0V7
VIYERMNQSLSLLYN	APP	536	P05067
VTGNYVKMSLQLYLV	PRKAA2	446	P54646
LQKIVEISYYNMGRI	ARFGEF1	1166	Q9Y6D6
QSANNVYLVMEYLIG	MASTL	101	Q96GX5
YIENMQYLLITSQIV	ABCA6	1081	Q8N139
RGYMEHEVYNILLQI	ANKRD35	981	Q8N283
SGYYQRMLVVLLQAN	ANXA5	146	P08758
LYRSHLLYAIQGQMD	ANKRD24	1111	Q8TF21
YLRGLVYLMQGQLLN	DENND3	561	A2RUS2
LMNLIQYIASYGDLQ	ATG2B	1356	Q96BY7
QYMGALQSIVPLFIY	CACUL1	216	Q86Y37
SILNYIMPVQYEGRQ	IQCG	76	Q9H095
MLHYQDLLQLQYEGV	IQGAP1	1616	P46940
INYVITMTTLYIQQL	NBEAL1	116	Q6ZS30
ELQSQVLDAMNYVLY	FBXO21	256	O94952
YYAIGPLLEQLENMQ	KCTD7	131	Q96MP8
MQLLLTVYYLVQLAA	GREB1	436	Q4ZG55
FYVSAQLQYIGVLEM	MYO16	1056	Q9Y6X6
YMVGTLELLVAENYL	BNIPL	241	Q7Z465
LTEIMNNYKVLIYNG	CPVL	371	Q9H3G5
YGMDYLQQVSELINR	ECE2	411	P0DPD6
ENYLIQMARYGQLSE	PDCD5	71	O14737
QVAQMLDILLTEYSY	PNLIPRP1	146	P54315
YYLSIDVNMGEVLLV	DLAT	446	P10515
AYNLTEQYLQLDLNM	CES5A	511	Q6NT32
TMEYQALQRAYALLQ	JAKMIP3	506	Q5VZ66
LSLVEMLQENYYLQE	LRRC74A	151	Q0VAA2
GSLVLMNQGYLQEAY	DSE	216	Q9UL01
IASSYLLQQLMHRYQ	LRGUK	56	Q96M69
AMQEYLAALYIVLGL	NLRX1	496	Q86UT6
SEVIQLMQYVIYGIA	GPM6B	81	Q13491
YLYGQQRMEIIPLNQ	PRDM6	176	Q9NQX0
IYLLAGSMVQVYEQV	DYNC2H1	2466	Q8NCM8
VVYGMDYLQQVSELI	EEF1AKMT4-ECE2	481	P0DPD8
LENLQIIRGNMYYEN	EGFR	101	P00533
SAEVLYQIANIYELM	IFT88	551	Q13099
EVAGREMLIYLAQYL	CPZ	251	Q66K79
GQYTNLLRLVDFYVM	CPB2	206	Q96IY4
ALIYLVLIAVGQNYM	ELOVL3	41	Q9HB03
VRQYYTLLNQAPDML	G3BP1	16	Q13283
NMLRALYGNLDLQVY	C5orf22	421	Q49AR2
NYILRALGQIMLYVD	FHOD3	166	Q2V2M9
YAQLSLRILYLEAGM	CDH4	671	P55283
QMSLYPELIASILYQ	DPY19L4	136	Q7Z388
GTLELLVAENYMIVY	BNIP2	196	Q12982
LVAENYMIVYLNGAT	BNIP2	201	Q12982
VSTLLNQMILTYYEG	FLVCR1	351	Q9Y5Y0
LLYFLVADLTQINYM	DNAH14	2716	Q0VDD8
LVGQRYNEVMATYLL	MARK2	346	Q7KZI7
QLLHLRYGNFQLYQM	IFIT2	371	P09913
GYIVLFYNMSLDVNR	ITGA4	511	P13612
GYLQMLQISNLYLYD	GRID1	311	Q9ULK0
LQISNLYLYDSVLML	GRID1	316	Q9ULK0
VYGQLLALYLLHNDM	COPS8	36	Q99627
TGLAGIMLLNYQQDY	SLC44A1	551	Q8WWI5
YQSYILRALGQLMLF	FHOD1	176	Q9Y613
LMILQVLGDMLNIYY	FAM87A	171	P0C7U9
AFYQVGILYMTTRLI	MFSD12	276	Q6NUT3
QINAVSLYLLYLVEM	PHKB	171	Q93100
YLVEMISSGLQIIYN	PHKB	181	Q93100
NQGYQLLRSMIGYIE	LIFR	706	P42702
YTYMAQAVNRGLTLV	NUP210L	1446	Q5VU65
PLRYSIIMNGVLYVQ	OR13D1	161	Q8NGV5
VRAMTYVINQGLALY	KCNAB3	211	O43448
YNPNMTILNLTIYII	MT-ND2	196	P03891
LSQIVLMQTVYYGSL	SYS1	16	Q8N2H4
YGLTMNPLLYNITQV	PHTF2	746	Q8N3S3
LQNIGAMSSYLYIIK	SLC38A3	151	Q99624
YMNGNYLVILVSVTI	SLC38A3	186	Q99624
SPTMVLYQGYLNLLL	TCP11X2	191	Q5H9J9
YINQMLLAQLAYREQ	SNX25	151	Q9H3E2
LTYYLQSINSLNDMV	PTCHD1	211	Q96NR3
AGYLLYIVASVLNNM	PKDREJ	706	Q9NTG1
FEYLMQLNTIAGRTY	NBEAL2	2076	Q6ZNJ1
ALRYTMYQNQLLEKI	SMG1	1396	Q96Q15
LYQQTLRAAGKTYMI	SCN9A	366	Q15858
MVLLLQSQRQYIFEY	TENM2	1941	Q9NT68
IGANYFNIMDNLLYV	PKHD1	3531	P08F94
GALIYRMHLNLEVLY	MRGPRX4	236	Q96LA9
NIYILNLAVADVLYM	SSTR5	76	P35346
YMLQVKYLLNQGIVL	SLC47A1	171	Q96FL8
GLFQYSTDNIYMLQI	SMURF1	461	Q9HCE7
NLYQLTLRAAGKTYM	SCN1A	386	P35498
QAVLYNALSAMLAYL	SLC39A6	656	Q13433
QFLIYLGTYMLRVLD	CIDEA	186	O60543
DVENSMLYYNQAVIL	CNOT10	106	Q9H9A5
YYIRLLVTSQLPQAM	TMEM268	296	Q5VZI3
GVYLGLLQMQLILHY	UNC93B1	76	Q9H1C4
AVYLFVQYIIMVNLL	TRPM6	1051	Q9BX84
LQLFIDYNLYGMNLI	REV3L	161	O60673
DYNLYGMNLINLAAV	REV3L	166	O60673
LTYLNQGQSYEIRML	TFCP2	86	Q12800
RDIAMATIYGQLYVL	RMC1	211	Q96DM3
LYQQTLRTSGKIYMI	SCN10A	361	Q9Y5Y9
VMLENYINLVSIGYR	ZNF577	51	Q9BSK1
RDNLYLLQAFMYILG	TSPAN15	86	O95858
FMVVYGNLLLILQYI	PIEZO2	546	Q9H5I5
ILELRYNGGINMYVL	SERPINB7	226	O75635
RQLYYQVLNFGMIVS	SEC11A	16	P67812
LQLTSMELNILYSYV	SMCO1	66	Q147U7
AYLSRFYMLLIQGLQ	RALGAPB	536	Q86X10
FYMLLIQGLQINDYV	RALGAPB	541	Q86X10
LQIQMYQLSRLLHDY	TBC1D4	1051	O60343
LEVDQYMLGILIYIQ	ZMIZ2	651	Q8NF64
QALYRDVMLENYGNL	ZNF517	36	Q6ZMY9
EALVLVAMTLGQIYY	TMED2	176	Q15363
YLLLFNYVILVRMDG	TRPM1	841	Q7Z4N2
LEMVNGQRGLVLYYS	TTC28	1226	Q96AY4
AAALLVNYITAYMVL	VAT1	166	Q99536
VYILMGFLLYEAVQR	SLC30A4	191	O14863
LYQYNILQMNAIPAA	TTC37	951	Q6PGP7
MLENYRNLVALGYQL	ZNF713	61	Q8N859
EYRNNMIVIGLYFIN	UGT1A6	111	P19224
YTQLLTEMVLRLPYQ	UBR4	3156	Q5T4S7
YRDVMLENYGNLVSV	ZNF485	36	Q8NCK3
LQAVYLFVQYIIMVN	TRPM7	1076	Q96QT4
IMNLLADFRNYQYTL	ZFYVE9	1106	O95405
MNLLVDLRNYQYTLH	ZFYVE16	1226	Q7Z3T8
MELPNYSRQLLQQLY	ZBTB40	1	Q9NUA8
MLLRQVCQLLGYYGN	TTI1	486	O43156
QELGIYTVSQMELYQ	MYO1H	56	Q8N1T3
AMISYILYGALLGLQ	MYO3B	131	Q8WXR4
QMFYIIGAITLNNLL	MYO5A	1691	Q9Y4I1