Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA replication origin binding

ORC1 GRWD1

4.49e-0418352GO:0003688
Domain-

RASA4B RASA4

1.02e-0533524.10.1130.10
DomainBTK

RASA4B RASA4

1.22e-049352SM00107
DomainZF_BTK

RASA4B RASA4

1.22e-049352PS51113
DomainZnf_Btk_motif

RASA4B RASA4

1.22e-049352IPR001562
DomainBTK

RASA4B RASA4

1.22e-049352PF00779
DomainRasGAP

RASA4B RASA4

3.06e-0414352SM00323
DomainRasGAP_CS

RASA4B RASA4

3.06e-0414352IPR023152
DomainRAS_GTPASE_ACTIV_2

RASA4B RASA4

3.53e-0415352PS50018
DomainRasGAP

RASA4B RASA4

3.53e-0415352PF00616
DomainRAS_GTPASE_ACTIV_1

RASA4B RASA4

3.53e-0415352PS00509
Domain-

RASA4B RASA4

4.03e-04163521.10.506.10
DomainRasGAP_dom

RASA4B RASA4

5.12e-0418352IPR001936
DomainRho_GTPase_activation_prot

RASA4B MYO9A RASA4

5.93e-0488353IPR008936
DomainPTB

APBB2 TNS1

2.54e-0340352SM00462
DomainPTB/PI_dom

APBB2 TNS1

2.67e-0341352IPR006020
DomainC2_dom

RASA4B TNS1 RASA4

3.54e-03164353IPR000008
Domainp53-like_TF_DNA-bd

NFATC2 MYRF

4.43e-0353352IPR008967
Domain-

APBB2 RASA4B TNS1 RASA4

5.93e-033913542.30.29.30
DomainPH_dom-like

APBB2 RASA4B TNS1 RASA4

7.99e-03426354IPR011993
Pubmed

CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.

RASA4B RASA4

1.04e-06236211448776
Pubmed

An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.

RASA4B RASA4

1.04e-06236216041389
Pubmed

Rescue of the genetically engineered Cul4b mutant mouse as a potential model for human X-linked mental retardation.

CUL4B EDIL3

1.04e-06236222763239
Pubmed

Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility.

CUL4B EDIL3

1.04e-06236226832838
Pubmed

Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis.

CUL4B EDIL3

3.12e-06336226846852
Pubmed

CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.

RASA4B RASA4

3.12e-06336225637021
Pubmed

Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.

RASA4B RASA4

6.24e-06436221460216
Pubmed

Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.

CUL4B EDIL3

6.24e-06436222453236
Pubmed

Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.

RASA4B RASA4

6.24e-06436216234249
Pubmed

X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling.

CUL4B EDIL3

1.56e-05636223357576
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

CUL4B KARS1 SRBD1 GRWD1 GTF3C1

2.58e-0534136532971831
Pubmed

Comparative genome mapping in the sequence-based era: early experience with human chromosome 7.

RASA4B RASA4

2.91e-05836210810084
Pubmed

An analysis of expression patterns of genes encoding proteins with catalytic activities.

CPN1 HK2 IDH3B

4.66e-056736317626619
Pubmed

Normal radial migration and lamination are maintained in dyslexia-susceptibility candidate gene homolog Kiaa0319 knockout mice.

KIAA0319 EDIL3

4.66e-051036227510895
Pubmed

Endoreduplication of the mouse genome in the absence of ORC1.

ORC1 EDIL3

4.66e-051036229967292
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

ORC1 KARS1 HK2 SF3B1 IDH3B SRBD1 GTF3C1 MYO9A

5.88e-05135336829467282
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

ORC1 KARS1 SF3B1 IDH3B SRBD1 GRWD1 GTF3C1

5.98e-0598936736424410
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

CUL4B SLITRK5 SF3B1 GTF3C1

7.16e-0521536435973513
Pubmed

Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.

KARS1 SF3B1 GPT2 MYRF

2.06e-0428336418854154
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

KARS1 HK2 SF3B1 IDH3B GTF3C1

2.13e-0453436535032548
Pubmed

Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.

EDIL3 TNS1

2.38e-042236224388013
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

PGS1 CLTCL1 SF3B1 NFATC2 TNS1

2.48e-0455236510737800
Pubmed

STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.

KARS1 SF3B1 SRBD1 GRWD1

3.13e-0431636431665637
Pubmed

FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.

CUL4B KARS1 SF3B1 IDH3B GTF3C1

3.67e-0460136533658012
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

KARS1 HK2 SF3B1 GTF3C1

3.77e-0433236432786267
Pubmed

CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.

CUL4B GRWD1

3.87e-042836217041588
Pubmed

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.

KARS1 SF3B1 SRBD1 GRWD1 GTF3C1

4.08e-0461536531048545
Pubmed

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.

MUC19 CLTCL1 GRWD1 GTF3C1

4.08e-0433936430415952
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

CUL4B KARS1 SF3B1 IDH3B GRWD1

4.82e-0463836533239621
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

CUL4B HK2 SF3B1 IDH3B GRWD1

5.35e-0465336533742100
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

ORC1 HK2 GTF3C1 NFATC2

5.67e-0437036422922362
Pubmed

Potential protein partners for the N-terminal domain of human topoisomerase I revealed by phage display.

SF3B1 GRWD1

5.72e-043436212549820
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

KARS1 CLTCL1 HK2 SF3B1 IDH3B GTF3C1 POMP

5.97e-04144036730833792
Pubmed

Endogenous human MDM2-C is highly expressed in human cancers and functions as a p53-independent growth activator.

KARS1 SF3B1

6.42e-043636224147044
Pubmed

Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.

CLTCL1 IDH3B GRWD1 GTF3C1

8.39e-0441136436652389
Pubmed

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.

IDH3B SRBD1 GRWD1 GTF3C1

8.86e-0441736436537216
Pubmed

Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion.

RASA4B RASA4

1.00e-034536219877281
GeneFamilyPleckstrin homology domain containing|SH2 domain containing|C2 and RasGAP domain containing

RASA4B RASA4

5.20e-0510202830
GeneFamilySH2 domain containing

TNS1 MATK

5.50e-03101202741
CoexpressionAtlasdev gonad_e11.5_F_SupCellPrec_Sry_k-means-cluster#3_top-relative-expression-ranked_500

CUL4B ORC1 MYO9A

1.04e-0526353gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_k3_500
CoexpressionAtlasdev gonad_e12.5_F_GermCellOvary_Oct_k-means-cluster#1_top-relative-expression-ranked_500

CUL4B ORC1

3.94e-056352gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_k1_500
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYRIA HK2 MYO9A MATK

7.71e-06157364ec433d2fe827abdb647be4176c231b7052482b6f
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HK2 GRWD1 NFATC2 MYO9A

1.18e-05175364bb058e714d21a0ec8532eaf3c7dd2faf78016bc0
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

GTF3C1 NFATC2 MYRF MATK

2.00e-05200364eda7a1d822e8663510662bc0ca34eaccc88d71ca
ToppCellPND14-Immune-Immune_Myeloid-Granulocytic|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PADI4 HK2 MATK

2.04e-04142363bf3537bec0eca9f90c00df9ba840c371f1c9856e
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Itm2a|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RASA4 KCNAB3 CEMIP

2.12e-041443630bbe670454846cf9bc7464ae4e91488415c4111d
ToppCellkidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CUL4B GTF3C1 RASA4

2.17e-0414536347a3bb973a508d3097213a2d86ad1ce697af9bae
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

RASA4B MYRF CEMIP

2.30e-04148363e7bbb5ddf44b11b8495e83863fbf1fd9f3f24472
ToppCell10x5'v1-week_14-16-Hematopoietic-HSC/MPP_and_pro-pDC_progenitor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

RASA4B GPT2 MATK

2.44e-041513638ffd71d847fe1aeebe7f43c4b6ca73efb19d6041
ToppCell368C-Endothelial_cells-Endothelial-E-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CLTCL1 EDIL3 KCNAB3

2.68e-041563631d681fa17e62815f5d5f90c86be3c248b38e011b
ToppCell368C-Endothelial_cells-Endothelial-E|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CLTCL1 EDIL3 KCNAB3

2.68e-041563634877aabf647238c0279e497345b6a6d5ee07ef9c
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage_3|367C / Donor, Lineage, Cell class and subclass (all cells)

CYRIA HK2 MATK

2.79e-041583630559cc032d0b518bb9e55aa3495f5573bd8e87dd
ToppCellNS-critical-d_0-4-Epithelial-unknown_epithelial|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PDCL MYRF KCNAB3

3.22e-04166363dd02bbe4af609c6348dc92417254f4740f2900a8
ToppCellPCW_05-06-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_conventional_dendritic_(19)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

MUC19 SLC22A16 MATK

3.34e-04168363907692c1f03d3c9889ba1bed5a4844e2c379db8e
ToppCellPND10-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GTF3C1 GPT2 POMP

3.39e-041693633e40ae0b23a962e0f15908872dec63f51c5b8b83
ToppCelldroplet-Pancreas-Exocrine-18m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPT2 TNS1 MYRF

3.39e-0416936353690d6f9712b54aa99a0408aae930d64ae478e5
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-MAIT_cell|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PGS1 GTF3C1 MATK

3.45e-04170363059f7ae615342ea19f43b0a405cd7272251a78a9
ToppCelldroplet-Pancreas-Exocrine-18m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPT2 TNS1 MYRF

3.51e-041713635447b78148f7bccb727e2fc108589b2af02a5d31
ToppCelldroplet-Pancreas-Exocrine|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPT2 TNS1 MYRF

3.51e-0417136392ac4cc3d54da2ea8e202aa59c78e8875356649e
ToppCelldroplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NFATC2 RASA4 MATK

3.51e-0417136338a05b5ec8ef8f09a2399994c6b4b9a707918ec1
ToppCelldroplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_ductal_cel|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPT2 TNS1 MYRF

3.57e-04172363a7eee0a30d2fe20c865a07b9004c6a821a72c0c4
ToppCellCOVID-19-kidney-PEC|kidney / Disease (COVID-19 only), tissue and cell type

EDIL3 TNS1 MYRF

3.57e-0417236336a96714a0eb6ac438648135336c9791881ddadb
ToppCellPND10-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PADI4 HK2 MATK

3.57e-04172363c05af6e559f6af0fb15cefa03ffa1413e98a1a4a
ToppCellNasal_Brush-Epithelial-Basal_1|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

CYRIA KCNAB3 CEMIP

3.57e-041723634483073469001770015526303772fd54906c5d68
ToppCellNasal_Brush-Epithelial-Basal_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

CYRIA KCNAB3 CEMIP

3.57e-0417236358eaadf12366701103a0d1f133462c9495fedc30
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Monocytes|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PADI4 HK2 SLC22A16

3.57e-04172363cf46810dd1072b6f2171e5d9530351ddc79a055b
ToppCelldroplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPT2 TNS1 MYRF

3.57e-041723630a9fe2cd28203970295a1288078c66eadac1c9ed
ToppCellPND10-Immune-Immune_Myeloid-Granulocytic-Basophil|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PADI4 HK2 MATK

3.57e-04172363953b05f776348cff784e79c93df65841939d880f
ToppCellAT1_cells-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

APBB2 PADI4 MYRF

3.63e-04173363b29816427428c7053017477f59b828bf1357f3b2
ToppCellControl-Epithelial_cells-AT1|Control / group, cell type (main and fine annotations)

APBB2 TNS1 MYRF

3.70e-04174363548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCelldroplet-Lung-21m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PADI4 HK2 MATK

3.70e-041743638a8e98e62c2859c004b44dbce6974c9639ebeac6
ToppCelldroplet-Lung-21m-Hematologic-myeloid-Basophil/Mast_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PADI4 HK2 MATK

3.70e-0417436331f7127faabcb1092bb9827db625f57cf7d8240e
ToppCellfacs-Pancreas-Exocrine-18m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPT2 TNS1 MYRF

3.76e-041753633f1b2e23fec953148fb0711e523c463adb07dca4
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CYRIA GTF3C1 MATK

3.76e-041753638fb8c4b9e2d9b7d737f59cd9bd3dc2bca5a8dfc4
ToppCellAT1_cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

APBB2 EDIL3 MYRF

3.82e-04176363458720776b0151cd55acc352d509599cb62f0ca8
ToppCellRV-11._Adipocyte|World / Chamber and Cluster_Paper

APBB2 HK2 GPT2

3.88e-04177363f0edf04930692418953e4f00a917257804ec0ffd
ToppCellRV-11._Adipocyte|RV / Chamber and Cluster_Paper

APBB2 HK2 GPT2

3.95e-04178363278bbea5cf8f0589f71675c7a3d00679391b5253
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIAA0319 EDIL3 CEMIP

3.95e-04178363731e1e8eff2c4018c75dfc66632a316010a09a9a
ToppCellfacs-Pancreas-Exocrine-18m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPT2 TNS1 MYRF

4.01e-04179363bbfbfb32773346080127055b5aafa36bbf7d0942
ToppCellAT1_cells-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

APBB2 TNS1 MYRF

4.08e-041803632d52cb5f77dde0e3dccac1333d4ec67ec680fcb2
ToppCellMesenchymal_cells-Chondrocytes|Mesenchymal_cells / Lineage and Cell class

SRBD1 EDIL3 CEMIP

4.08e-041803636e399368430ef3afa9ce1ef0ed90f614ccef9987
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

APBB2 TNS1 MYRF

4.35e-0418436357c792e6e2fedba25d3350ffe649fd74750b579d
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

APBB2 TNS1 MYRF

4.35e-04184363d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCellCOPD-Myeloid-cMonocyte|World / Disease state, Lineage and Cell class

CYRIA PGS1 PADI4

4.35e-04184363ceec41ed5636032aaf7716d1203816ea58bd39bd
ToppCell367C-Lymphocytic-NK_cells-NK_cell_A|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

GTF3C1 MYRF MATK

4.42e-0418536325781cf68e693e97dc1885e2879ab24fa946b51e
ToppCelldroplet-Bladder-BLADDER-1m-Hematologic-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFATC2 RASA4 ZBTB25

4.42e-04185363969248b63d4ce335f223528de756bcddffadbd77
ToppCellmild-Myeloid-Immature_Neutrophils_1|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PADI4 CLTCL1 HK2

4.42e-04185363d747bc91fc276f12a5572ab0223fc71f829a5110
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EDIL3 TNS1 MYO9A

4.49e-04186363f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

APBB2 EDIL3 TNS1

4.49e-04186363888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EDIL3 TNS1 MYO9A

4.56e-04187363c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_3|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

CYRIA HK2 ZBTB25

4.56e-041873631eed2c1a05e80a7c8f639437c117afe0c18dfb0c
ToppCellControl-Epithelial-ATI|Epithelial / Disease state, Lineage and Cell class

APBB2 TNS1 MYRF

4.56e-041873633a032432f780525f4f4c2a358897d9989b1ecae7
ToppCelldroplet-Marrow-nan-18m-Myeloid-Cd4_positive_Macrophages|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRWD1 RASA4 MATK

4.63e-041883631ff13434dfe60c8184d5f33041e325eca41392bc
ToppCelldroplet-Marrow-nan-18m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRWD1 RASA4 MATK

4.63e-041883639fc3f17045606f1fe29d296326da9482db58433b
ToppCelldroplet-Marrow-nan-21m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRWD1 RASA4 MATK

4.63e-041883637c67330c36696a7772364af67c6df4e6406fa742
ToppCelldroplet-Marrow-nan-21m-Myeloid-Cd4_positive_Macrophages|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRWD1 RASA4 MATK

4.63e-04188363f94dc08948a823f47882aa0714b9a60de4ff85d5
ToppCellCOPD-Myeloid-cMonocyte|COPD / Disease state, Lineage and Cell class

CYRIA PGS1 PADI4

4.70e-04189363d29f3a0bd23e6eb46389e6eb7ef21851c7b57545
ToppCellCOPD-Myeloid-cMonocyte|Myeloid / Disease state, Lineage and Cell class

CYRIA PGS1 PADI4

4.70e-041893636294691231c7d38707323cf31578a107d3b2c622
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

APBB2 TNS1 MYRF

4.78e-0419036330b50d183d7649146eb1e79b47ba897355f1998a
ToppCellIPF-Myeloid-cMonocyte|World / Disease state, Lineage and Cell class

CYRIA PGS1 PADI4

4.78e-04190363ffa890138394f579fee53fcfac6c121bf86adc26
ToppCellIPF-Myeloid-cMonocyte|IPF / Disease state, Lineage and Cell class

CYRIA PGS1 PADI4

4.78e-04190363a099f51f2b7618b6712af38eedd5ee64d8663a4a
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

APBB2 EDIL3 TNS1

4.78e-041903634eb92aef1ee868f4537483d19014d947b7684612
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

APBB2 EDIL3 TNS1

4.78e-041903637be4341e2909101d756f14031c21e705eb45e69a
ToppCellLAM-Epithelial-AT1|Epithelial / Condition, Lineage and Cell class

APBB2 TNS1 MYRF

4.85e-041913633457e15d1e9b36a78363d46b320c4ec46b40290a
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLITRK5 GPT2 NFATC2

4.85e-04191363ece87127f85939e61b1048d968ed96f0e87c3a79
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLITRK5 GPT2 NFATC2

4.85e-04191363478e8341ee03b05501e2233e02cef5f97492c95d
ToppCellSmart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MUC19 PADI4 CLTCL1

4.85e-04191363d4f77c73311d1149466bbfe4adbd6a301946ec90
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GTF3C1 NFATC2 MATK

4.92e-0419236358a7829b411b02b422ef75e2277a868969cc23e8
ToppCell(210)_NKT_cell|World / immune cells in Peripheral Blood (logTPM normalization)

GTF3C1 NFATC2 MATK

4.92e-0419236308dc0c019c594da7b9944db8fd706aa7780e6ae9
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_T-CytoT_GZMH+|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

GTF3C1 NFATC2 MATK

4.92e-0419236301d01c9293f2439dc4c34c648273319c9beee5c7
ToppCell(21)_NKT_cell|World / immune cells in Peripheral Blood (logTPM normalization)

GTF3C1 NFATC2 MATK

4.92e-04192363b0a573ddde2978485a857b8261ee1ee5ef68ecef
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_T-CytoT_GZMH+-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

GTF3C1 NFATC2 MATK

4.92e-041923630f8c63de26128694f4522f9f6d029e4628c890bc
ToppCellControl-Myeloid-cMonocyte|Control / Disease state, Lineage and Cell class

CYRIA PGS1 PADI4

4.92e-04192363ad04c9c4bdebf94615cee1904ca48197e62c923b
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GTF3C1 NFATC2 MATK

4.92e-04192363ce867b6e78c1d8f30dff81bf572a78a897bc7625
ToppCell(3)_Chondrocytes|World / Cell class and subclass of bone marrow stroma cells in homeostatis

NFATC2 EDIL3 CEMIP

4.92e-041923635d2b4830d025d3dbdf5623ce1c28d1036e1984a8
ToppCellSmart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MUC19 PADI4 CLTCL1

5.00e-04193363e1855cff9a6bcfda9188b9fdf6c9d698405da990
ToppCellPosterior_cortex-Neuronal|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

KIAA0319 MYO9A MATK

5.00e-04193363b4989e3436e84dbec3789b46057e0f7a0ebf09d4
ToppCellCOPD-Myeloid-ncMonocyte|COPD / Disease state, Lineage and Cell class

CYRIA PGS1 PADI4

5.00e-04193363936ca95995599356b794fba32bfd82d8de339365
ToppCellICU-SEP-Lymphocyte-T_NK-NK|ICU-SEP / Disease, Lineage and Cell Type

GTF3C1 NFATC2 MATK

5.00e-04193363f110f86db305e41639087f5b1a2dff103c07adf0
ToppCellControl-Myeloid-cMonocyte|World / Disease state, Lineage and Cell class

CYRIA PGS1 PADI4

5.08e-04194363f852f5258617a66a4fbd56d64c7b47272e7b8b60
ToppCell10x5'-blood-Lymphocytic_NK-NK_CD16|blood / Manually curated celltypes from each tissue

GTF3C1 NFATC2 MATK

5.08e-04194363c34a32f1cfe3e597cb0f91ba5bdd3e114e9f3d2e
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CYRIA GTF3C1 MATK

5.08e-04194363a8dc3336aa4ef497f6d26cede02ddac425e7c655
ToppCellT_cells-CD56_dim_CD16+_NK_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

NFATC2 MYRF MATK

5.08e-04194363335c6c2f3f319d4f19eace62f8826a0f40c130f6
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SLITRK5 APBB2 EDIL3

5.08e-0419436399577a5a631e607b5abe7a1b0d8d6a5eabe50196
ToppCell356C-Epithelial_cells-Epithelial-I_(AT1)-|356C / Donor, Lineage, Cell class and subclass (all cells)

APBB2 TNS1 MYRF

5.15e-04195363b65511770ed67f7447847e2187555b362988af45
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Capillary_Aerocyte_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APBB2 EDIL3 RASA4

5.15e-04195363cad21edd90bf3e2fefdf5773a59cb1a664a69ddd
ToppCell356C-Epithelial_cells-Epithelial-I_(AT1)|356C / Donor, Lineage, Cell class and subclass (all cells)

APBB2 TNS1 MYRF

5.15e-0419536307a3ef6b0f1201fe2bcb9ea426b8f7a69beb4904
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KIAA0319 APBB2 MYRF

5.15e-04195363a71ba5e4043e2d35a45a2c60a96b087e31832345
ToppCell10x5'-blood-Lymphocytic_NK|blood / Manually curated celltypes from each tissue

GTF3C1 NFATC2 MATK

5.15e-04195363c1db871e8e8e8b8d6a5798bc43eaf54e102b75eb
ToppCellCV-Moderate-6|Moderate / Virus stimulation, Condition and Cluster

GTF3C1 NFATC2 MATK

5.15e-041953632b8a72d7e755b9655c7a496000d10ff06e50862b
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GTF3C1 NFATC2 MATK

5.15e-041953630b50b5c71a4949f3f8fb9f5c30f9d50f53ca050d
ToppCellCOVID-19_Severe-Lymphoid_T/NK-gd_T|COVID-19_Severe / Disease group, lineage and cell class

GTF3C1 NFATC2 MATK

5.15e-041953639990440bda7fac5d00ef80444fab07459be625e1
ToppCell10x5'-Liver-Lymphocytic_NK-NK_CD16|Liver / Manually curated celltypes from each tissue

GTF3C1 NFATC2 MATK

5.23e-04196363e6d4853ccefbcd45a019cee595811f0474dcc036
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

APBB2 TNS1 MYRF

5.23e-04196363eb68f7954e7c2f86d05e740e95b6e74805a6053f
ToppCell(1)_T_cells-(1)_T_CD8_CTL|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)

GTF3C1 MYRF MATK

5.23e-04196363ad9b0651cb2a15b750e453b2dcf782bca08b4fe7
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GTF3C1 NFATC2 MATK

5.23e-0419636377da6b1bcab45d376eb0368f540e0ed24ce98b42
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GTF3C1 NFATC2 MATK

5.23e-041963636beaf0c2799424c59819b286fbb5c1a83d85e4d1
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GTF3C1 NFATC2 MATK

5.23e-04196363c35f2349dfe35baa845f790b9f31673dceac54c0
ToppCell(1)_T_cells-(1)_T_CD8_CytT|(1)_T_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

CYRIA GTF3C1 MATK

5.23e-041963633a4ba9ca84ce6b35038765da8c55812587b58bc2
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

GTF3C1 NFATC2 MATK

5.23e-04196363418e8e0a51c5cb60e3b903e7d2d800dc8b9f3d5c
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

GTF3C1 NFATC2 MATK

5.23e-04196363d3bd8fab010e76024d7e06aba0ea5df3394f411f
Drug0393-0188; Up 200; 10uM; PC3; HT_HG-U133A

SLITRK5 EDIL3 TNS1 MYRF CEMIP

9.23e-061923457536_UP
DrugCarbetapentane citrate [23142-01-0]; Up 200; 7.6uM; PC3; HT_HG-U133A

PADI4 CLTCL1 EDIL3 TNS1 CNGB3

1.10e-051993454649_UP
DrugDesipramine hydrochloride [58-28-6]; Down 200; 13.2uM; PC3; HT_HG-U133A

APBB2 ORC1 TNS1 MYRF CEMIP

1.10e-051993456693_DN
Diseaseanxiety disorder, stress-related disorder

EDIL3 CNGB3

8.44e-0512342EFO_0006788, EFO_0010098
Diseasedihomo-linolenoylcarnitine (C20:3n3 or 6) measurement

SLC22A16 MYRF

9.97e-0513342EFO_0800547
Diseaselysophosphatidylcholine 22:5 measurement

NFATC2 MYRF

1.16e-0414342EFO_0021462
Diseasearachidonic acid measurement

SLC22A16 MYRF

3.80e-0425342EFO_0006808
Diseasetriacylglycerol 56:7 measurement

EDIL3 MYRF

5.13e-0429342EFO_0010434
DiseaseVaricose veins

SLITRK5 NFATC2 CNGB3

1.42e-03193343HP_0002619
Diseaseglycerophospholipid measurement

PGS1 MYRF

1.46e-0349342EFO_0007630
Diseaselysophosphatidylcholine measurement

SRBD1 MYRF

2.33e-0362342EFO_0010224
DiseaseMicrocephaly

ORC1 GPT2

2.72e-0367342C0025958
Diseasefatty acid measurement, linoleic acid measurement

MYRF LPCAT3

2.80e-0368342EFO_0005110, EFO_0006807
Diseaseerythrocyte measurement

TNS1 MYRF LPCAT3

3.20e-03257343EFO_0005047
DiseaseNonsyndromic Deafness

KARS1 CEMIP

3.94e-0381342C3711374

Protein segments in the cluster

PeptideGeneStartEntry
GGYMEVINLHPEIKG

GPT2

351

Q8TD30
HVQYLGMLPVDKPVG

APBB2

591

Q92870
QVKVAGKPMYLHIGE

CEMIP

466

Q8WUJ3
MQYLHGVLGPIINKV

RASA4

361

O43374
MQYLHGVLGPIINKV

RASA4B

361

C9J798
EMEIGYIQAPHKTLP

PADI4

351

Q9UM07
PVVQLHGYMENKPLG

NFATC2

441

Q13469
HGYMENKPLGLQIFI

NFATC2

446

Q13469
MVGVIILYDHVHPVG

CYRIA

256

Q9H0Q0
LLGVILHQGLYIVME

MATK

291

P42679
LELAMVPHYGGINRV

GRWD1

141

Q9BQ67
GGVEMHNKIYAIPQE

HK2

551

P52789
CYINDEVMQPGKLIH

MUC19

1136

Q7Z5P9
TVQVVDGMVHPYKGD

PGS1

281

Q32NB8
NHYMKLVQGELIDIP

LPCAT3

206

Q6P1A2
VMGEPHLMVEYKLGL

POMP

126

Q9Y244
IEVNGMKLTEPHQVY

ORC1

566

Q13415
EPLGMKSGHIQDYQI

EDIL3

321

O43854
IIGKIHTPMEYKGEL

IDH3B

111

O43837
IHEPLEPEVKYVGNM

CPN1

71

P15169
GQKLMQEREVPEYLH

CUL4B

401

Q13620
IVIMVHIYEDGIPGT

PDCL

181

Q13371
VEMQLPELYHKIGVG

KCNAB3

266

O43448
ELYHKMLVVGGIDRV

KARS1

301

Q15046
PQKHYILGVVTAMVG

SLC22A16

436

Q86VW1
KIEPKHIGVGMYQHD

SRBD1

671

Q8N5C6
PVAMQIGAKHGVIYL

CLTCL1

261

P53675
MYIIKHGEVQVLGGP

CNGB3

561

Q9NQW8
LLHIMYTGKGPKQIV

ZBTB25

76

P24278
PYVGLLQHMDKVVEL

SLITRK5

216

O94991
QEEKLMGHLGVVLYE

SF3B1

966

O75533
YGPEKIQGMEHLENG

TNS1

306

Q9HBL0
VQYPGEGPQLHLKAM

TRAV9-1

56

A0A075B6T8
DVYPIHMILENKDGI

GTF3C1

96

Q12789
EGKHVVMQGVQTPYL

KIAA0319

571

Q5VV43
PLVVEKLINYIEMHG

MYO9A

2076

B2RTY4
HFQVTVYIGMLGEPK

MYRF

401

Q9Y2G1