Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionchromatin binding

TPR PHC3 SP3 RUNX2 BRCA1 ARID1A EP400 CLOCK NIPBL TCF7L1 MED12

1.90e-077394111GO:0003682
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

MED15 MED12L TPR IRAK1BP1 KMT2C ANK1 BRCA1 ARID1A NIPBL MED12 SUPT7L

1.52e-0511604111GO:0030674
GeneOntologyMolecularFunctiontranscription coregulator activity

MED15 MED12L KMT2C BRCA1 ARID1A NIPBL MED12 SUPT7L

1.58e-05562418GO:0003712
GeneOntologyMolecularFunctiontranscription coactivator activity

MED12L KMT2C BRCA1 ARID1A MED12 SUPT7L

3.34e-05303416GO:0003713
GeneOntologyMolecularFunctionmolecular adaptor activity

MED15 MED12L TPR IRAK1BP1 KMT2C ANK1 BRCA1 ARID1A NIPBL MED12 SUPT7L

6.44e-0513564111GO:0060090
GeneOntologyMolecularFunctiontranscription factor binding

NFYA MED12L BDP1 SP3 RUNX2 ARID1A CLOCK MED12

1.25e-04753418GO:0008134
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

NFYA NFYC SP2 SP3 SP4 RUNX2 CLOCK RFX3 TCF7L1 MED12

1.61e-0412444110GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

NFYA NFYC SP2 SP3 SP4 RUNX2 CLOCK RFX3 TCF7L1 MED12

1.92e-0412714110GO:0000987
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

NFYA NFYC SP2 SP3 SP4 RUNX2 CLOCK RFX3 TCF7L1 MED12

5.80e-0414594110GO:0000977
GeneOntologyMolecularFunctionnuclear import signal receptor activity

KPNA4 KPNA3

7.63e-0420412GO:0061608
GeneOntologyMolecularFunctionnuclear localization sequence binding

KPNA4 KPNA3

1.40e-0327412GO:0008139
GeneOntologyMolecularFunctionbeta-catenin binding

MED12L TCF7L1 MED12

1.91e-03120413GO:0008013
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

NFYA NFYC SP2 SP3 SP4 RUNX2 CLOCK RFX3 TCF7L1

1.91e-031412419GO:0000981
GeneOntologyMolecularFunctionnucleocytoplasmic carrier activity

KPNA4 KPNA3

1.96e-0332412GO:0140142
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

ARID1A EP400

2.62e-0337412GO:0140658
GeneOntologyMolecularFunctionhistone deacetylase binding

SP2 RUNX2 NIPBL

3.40e-03147413GO:0042826
GeneOntologyMolecularFunctionsignal sequence binding

KPNA4 KPNA3

4.92e-0351412GO:0005048
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

NFYA MED15 NFYC MED12L KMT2C SP3 RUNX2 BRCA1 CLOCK RFX3 NIPBL TCF7L1 MED12

2.25e-0613904213GO:0045944
GeneOntologyBiologicalProcessprotein-DNA complex organization

MED15 BDP1 TPR KMT2C BRCA1 ARID1A EP400 CLOCK NIPBL TCF7L1 SMC6

3.49e-069994211GO:0071824
GeneOntologyBiologicalProcessnegative regulation of DNA-templated transcription

TPR SP2 PHC3 SP3 RUNX2 BRCA1 ARID1A CLOCK RFX3 NIPBL TCF7L1 SCAF4

1.48e-0513994212GO:0045892
GeneOntologyBiologicalProcessnegative regulation of RNA biosynthetic process

TPR SP2 PHC3 SP3 RUNX2 BRCA1 ARID1A CLOCK RFX3 NIPBL TCF7L1 SCAF4

1.64e-0514134212GO:1902679
GeneOntologyBiologicalProcessembryonic eye morphogenesis

MFAP2 SP3 ARID1A

6.30e-0538423GO:0048048
GeneOntologyBiologicalProcesschromatin organization

TPR KMT2C BRCA1 ARID1A EP400 CLOCK NIPBL TCF7L1 SMC6

6.47e-05896429GO:0006325
GeneOntologyBiologicalProcesssomatic stem cell population maintenance

MED15 NIPBL TCF7L1 MED12

6.83e-05108424GO:0035019
GeneOntologyBiologicalProcessembryonic organ morphogenesis

MFAP2 SP3 RUNX2 ARID1A NIPBL MED12

7.28e-05351426GO:0048562
GeneOntologyBiologicalProcessprotein localization to nucleus

CIZ1 KPNA4 TPR BRCA1 SUPT7L KPNA3

8.63e-05362426GO:0034504
GeneOntologyBiologicalProcessstem cell population maintenance

MED15 ARID1A NIPBL TCF7L1 MED12

1.15e-04237425GO:0019827
GeneOntologyBiologicalProcessembryonic organ development

SP2 MFAP2 SP3 RUNX2 ARID1A NIPBL MED12

1.25e-04561427GO:0048568
GeneOntologyBiologicalProcessmaintenance of cell number

MED15 ARID1A NIPBL TCF7L1 MED12

1.27e-04242425GO:0098727
GeneOntologyBiologicalProcessembryonic cranial skeleton morphogenesis

RUNX2 NIPBL MED12

1.62e-0452423GO:0048701
GeneOntologyBiologicalProcessregulation of type B pancreatic cell development

CLOCK RFX3

1.80e-0410422GO:2000074
GeneOntologyBiologicalProcessembryonic skeletal system development

SP3 RUNX2 NIPBL MED12

2.30e-04148424GO:0048706
GeneOntologyBiologicalProcessdouble-strand break repair

BRCA1 ARID1A EP400 NIPBL SMC6

4.90e-04324425GO:0006302
GeneOntologyBiologicalProcesscellular response to ionizing radiation

BRCA1 CLOCK NIPBL

4.98e-0476423GO:0071479
GeneOntologyBiologicalProcessnuclear receptor-mediated glucocorticoid signaling pathway

ARID1A CLOCK

5.40e-0417422GO:0042921
GeneOntologyBiologicalProcessdouble-strand break repair via homologous recombination

BRCA1 EP400 NIPBL SMC6

5.71e-04188424GO:0000724
GeneOntologyBiologicalProcessnuclear receptor-mediated corticosteroid signaling pathway

ARID1A CLOCK

6.07e-0418422GO:0031958
GeneOntologyBiologicalProcessrecombinational repair

BRCA1 EP400 NIPBL SMC6

6.42e-04194424GO:0000725
GeneOntologyBiologicalProcessprotein import into nucleus

KPNA4 TPR BRCA1 KPNA3

6.55e-04195424GO:0006606
GeneOntologyBiologicalProcesscranial skeletal system development

RUNX2 NIPBL MED12

6.67e-0484423GO:1904888
GeneOntologyBiologicalProcesschromatin remodeling

TPR KMT2C BRCA1 ARID1A EP400 CLOCK NIPBL

6.76e-04741427GO:0006338
GeneOntologyBiologicalProcessimport into nucleus

KPNA4 TPR BRCA1 KPNA3

7.33e-04201424GO:0051170
GeneOntologyBiologicalProcessNLS-bearing protein import into nucleus

KPNA4 KPNA3

7.51e-0420422GO:0006607
GeneOntologyBiologicalProcesseye morphogenesis

MFAP2 SP3 ARID1A NIPBL

7.75e-04204424GO:0048592
GeneOntologyBiologicalProcessregulation of DNA metabolic process

CIZ1 BRCA1 ARID1A EP400 SUPT7L SMC6

9.25e-04564426GO:0051052
GeneOntologyBiologicalProcessnuclear transport

KPNA4 TPR SMG7 BRCA1 KPNA3

9.81e-04378425GO:0051169
GeneOntologyBiologicalProcessnucleocytoplasmic transport

KPNA4 TPR SMG7 BRCA1 KPNA3

9.81e-04378425GO:0006913
GeneOntologyBiologicalProcessDNA-templated transcription initiation

MED15 BDP1 ARID1A MED12

1.23e-03231424GO:0006352
GeneOntologyBiologicalProcessmaintenance of protein location in nucleus

CIZ1 SUPT7L

1.28e-0326422GO:0051457
GeneOntologyBiologicalProcessregulation of DNA repair

BRCA1 ARID1A EP400 SUPT7L

1.29e-03234424GO:0006282
GeneOntologyBiologicalProcessprotein localization to organelle

CIZ1 KPNA4 FSIP2 TPR BRCA1 NIPBL SUPT7L KPNA3

1.41e-031091428GO:0033365
GeneOntologyBiologicalProcessembryonic skeletal system morphogenesis

RUNX2 NIPBL MED12

1.42e-03109423GO:0048704
GeneOntologyBiologicalProcesstype B pancreatic cell development

CLOCK RFX3

1.59e-0329422GO:0003323
GeneOntologyCellularComponentnuclear protein-containing complex

NFYA KPNA4 MED15 NFYC MED12L TPR KMT2C PHC3 SMG7 BRCA1 ARID1A EP400 CLOCK NIPBL TCF7L1 MED12 KPNA3

2.50e-1013774117GO:0140513
GeneOntologyCellularComponenttranscription regulator complex

NFYA MED15 NFYC BDP1 SP3 RUNX2 CLOCK RFX3 TCF7L1

1.82e-06596419GO:0005667
GeneOntologyCellularComponentchromatin

NFYA NFYC SP2 SP3 SP4 RUNX2 ARID1A EP400 CLOCK RFX3 NIPBL TCF7L1 SUPT7L

2.88e-0614804113GO:0000785
GeneOntologyCellularComponentCCAAT-binding factor complex

NFYA NFYC

5.60e-056412GO:0016602
GeneOntologyCellularComponentNLS-dependent protein nuclear import complex

KPNA4 KPNA3

1.67e-0410412GO:0042564
GeneOntologyCellularComponentRNA polymerase II transcription regulator complex

NFYA MED15 NFYC CLOCK TCF7L1

1.84e-04272415GO:0090575
GeneOntologyCellularComponentnucleocytoplasmic transport complex

KPNA4 KPNA3

2.45e-0412412GO:0031074
GeneOntologyCellularComponentnuclear pore

KPNA4 TPR KPNA3

1.02e-03101413GO:0005643
GeneOntologyCellularComponentmediator complex

MED12L MED12

2.39e-0337412GO:0016592
GeneOntologyCellularComponenttransferase complex

KMT2C PHC3 BRCA1 EP400 MED12 SUPT7L SMC6

2.46e-03963417GO:1990234
HumanPhenoThin vermilion border

MED12L TPR ABCC9 CEP152 QRICH1 RUNX2 BRCA1 ARID1A NIPBL MED12

2.01e-074331710HP:0000233
HumanPhenoThin upper lip vermilion

MED12L TPR ABCC9 CEP152 QRICH1 BRCA1 ARID1A NIPBL MED12

3.48e-07339179HP:0000219
HumanPhenoThin lips

MED12L TPR ABCC9 CEP152 QRICH1 BRCA1 ARID1A NIPBL MED12

3.48e-07339179HP:0000213
HumanPhenoAbnormality of upper lip vermillion

MED12L TPR ABCC9 CEP152 QRICH1 BRCA1 ARID1A NIPBL MED12

5.00e-06464179HP:0011339
HumanPhenoAbnormal external nose morphology

MED12L TPR ABCC9 CEP152 QRICH1 RUNX2 BRCA1 ARID1A NIPBL MED12 SCAF4

2.58e-059161711HP:0010938
HumanPhenoAbnormal upper lip morphology

MED12L TPR ABCC9 CEP152 QRICH1 RUNX2 BRCA1 ARID1A NIPBL MED12 SCAF4

5.01e-059801711HP:0000177
HumanPhenoHigh palate

MED12L CEP152 QRICH1 RUNX2 ANK1 BRCA1 ARID1A NIPBL MED12 SCAF4

5.47e-057941710HP:0000218
HumanPhenoMalrotation of colon

NIPBL MED12

6.27e-054172HP:0004785
HumanPhenoAbnormal lip morphology

MED12L TPR ABCC9 KMT2C CEP152 QRICH1 RUNX2 BRCA1 ARID1A NIPBL MED12 SCAF4

7.90e-0512491712HP:0000159
HumanPhenoAbnormal lower lip morphology

MED12L ABCC9 KMT2C QRICH1 ARID1A MED12

8.59e-05242176HP:0000178
HumanPhenoSupernumerary ribs

RUNX2 ANK1 NIPBL

9.61e-0528173HP:0005815
HumanPhenoAplasia/Hypoplasia of fingers

ABCC9 CEP152 RUNX2 BRCA1 ARID1A NIPBL MED12

9.66e-05366177HP:0006265
HumanPhenoSupernumerary bones of the axial skeleton

RUNX2 ANK1 NIPBL

1.07e-0429173HP:0009144
HumanPhenoRecurrent maladaptive behavior

CIZ1 MED12L TPR ABCC9 KMT2C CEP152 BRCA1 ARID1A NIPBL MED12 SCAF4 KPNA3

1.14e-0412931712HP:5200241
HumanPhenoProminent lips

ABCC9 KMT2C BRCA1 ARID1A MED12

1.16e-04156175HP:0000184
HumanPhenoAbnormal nasal tip morphology

MED12L TPR ABCC9 QRICH1 ARID1A MED12 SCAF4

1.36e-04386177HP:0000436
HumanPhenoAbnormality of the philtrum

MED12L TPR ABCC9 QRICH1 RUNX2 ARID1A NIPBL MED12 SCAF4

1.92e-04726179HP:0000288
HumanPhenoClinodactyly

TPR CEP152 QRICH1 RUNX2 BRCA1 ARID1A NIPBL MED12

2.38e-04574178HP:0030084
HumanPhenoShort phalanx of finger

ABCC9 CEP152 RUNX2 ARID1A NIPBL MED12

3.15e-04306176HP:0009803
HumanPhenoRadial deviation of finger

TPR CEP152 QRICH1 RUNX2 BRCA1 NIPBL MED12

3.46e-04448177HP:0009466
HumanPhenoAbnormal palate morphology

MED12L KMT2C CEP152 QRICH1 RUNX2 ANK1 BRCA1 ARID1A NIPBL MED12 SCAF4

3.56e-0412021711HP:0000174
HumanPhenoFinger clinodactyly

TPR CEP152 QRICH1 RUNX2 BRCA1 NIPBL MED12

3.66e-04452177HP:0040019
HumanPhenoRadial deviation of the hand or of fingers of the hand

TPR CEP152 QRICH1 RUNX2 BRCA1 NIPBL MED12

3.86e-04456177HP:0009485
HumanPhenoNarrow palate

MED12L RUNX2 BRCA1 NIPBL MED12

3.91e-04202175HP:0000189
HumanPhenoAplasia/Hypoplasia of the phalanges of the hand

ABCC9 CEP152 RUNX2 ARID1A NIPBL MED12

3.95e-04319176HP:0009767
HumanPhenoShort finger

ABCC9 CEP152 RUNX2 ARID1A NIPBL MED12

4.37e-04325176HP:0009381
HumanPhenoAbnormal morphology of the nasal alae

MED12L TPR ABCC9 QRICH1 BRCA1 ARID1A NIPBL MED12

5.04e-04639178HP:0000429
HumanPhenoAbnormality of the frontal hairline

ABCC9 BRCA1 ARID1A NIPBL MED12

5.22e-04215175HP:0000599
HumanPhenoAbnormal nasal bridge morphology

MED12L TPR ABCC9 CEP152 RUNX2 ANK1 BRCA1 ARID1A NIPBL MED12

5.24e-0410291710HP:0000422
HumanPhenoLong eyelashes

ABCC9 BRCA1 ARID1A NIPBL

7.23e-04129174HP:0000527
HumanPhenoBlepharophimosis

CEP152 ANK1 BRCA1 MED12

7.23e-04129174HP:0000581
HumanPhenoAbnormal 5th finger morphology

TPR CEP152 QRICH1 RUNX2 BRCA1 ARID1A NIPBL

7.60e-04509177HP:0004207
HumanPhenoPes planus

MED12L TPR CEP152 BRCA1 MED12 SCAF4

8.15e-04365176HP:0001763
HumanPhenoAggressive behavior

MED12L KMT2C CEP152 ARID1A NIPBL MED12 SCAF4

8.26e-04516177HP:0000718
HumanPhenoAbnormal aggressive, impulsive or violent behavior

MED12L KMT2C CEP152 ARID1A NIPBL MED12 SCAF4

8.26e-04516177HP:0006919
HumanPhenoThick lower lip vermilion

ABCC9 KMT2C ARID1A MED12

8.83e-04136174HP:0000179
HumanPhenoAbnormal thorax morphology

MED12L ABCC9 KMT2C CEP152 RUNX2 ANK1 BRCA1 ARID1A NIPBL MED12 SCAF4

9.01e-0413281711HP:0000765
HumanPhenoLimited elbow extension

ABCC9 NIPBL MED12

9.39e-0460173HP:0001377
HumanPhenoHypospadias

MED12L CEP152 BRCA1 ARID1A NIPBL MED12

9.68e-04377176HP:0000047
HumanPhenoDeviation of finger

TPR CEP152 QRICH1 RUNX2 BRCA1 NIPBL MED12

1.05e-03537177HP:0004097
HumanPhenoAplasia/hypoplasia involving bones of the hand

ABCC9 CEP152 RUNX2 BRCA1 ARID1A NIPBL MED12

1.06e-03538177HP:0005927
HumanPhenoAnal atresia

KMT2C BRCA1 MED12 SCAF4

1.07e-03143174HP:0002023
HumanPhenoCurly eyelashes

ABCC9 NIPBL

1.07e-0315172HP:0007665
HumanPhenoLow anterior hairline

ABCC9 BRCA1 ARID1A NIPBL

1.18e-03147174HP:0000294
HumanPhenoImpairment in personality functioning

CIZ1 MED12L ABCC9 KMT2C CEP152 ARID1A NIPBL MED12 SCAF4 KPNA3

1.25e-0311411710HP:0031466
HumanPhenoDisplacement of the urethral meatus

MED12L CEP152 BRCA1 ARID1A NIPBL MED12

1.27e-03397176HP:0100627
HumanPhenoAbnormal male urethral meatus morphology

MED12L CEP152 BRCA1 ARID1A NIPBL MED12

1.31e-03399176HP:0032076
HumanPhenoAbnormal finger morphology

MED12L TPR ABCC9 KMT2C CEP152 QRICH1 RUNX2 BRCA1 ARID1A NIPBL MED12

1.32e-0313851711HP:0001167
HumanPhenoAnteverted nares

MED12L TPR ABCC9 QRICH1 BRCA1 ARID1A NIPBL

1.34e-03559177HP:0000463
HumanPhenoUpturned nose

MED12L TPR ABCC9 QRICH1 BRCA1 ARID1A NIPBL

1.34e-03559177HP:0000427
HumanPhenoThick eyebrow

ABCC9 KMT2C ARID1A NIPBL

1.41e-03154174HP:0000574
HumanPhenoDeviation of the hand or of fingers of the hand

TPR CEP152 QRICH1 RUNX2 BRCA1 NIPBL MED12

1.41e-03564177HP:0009484
HumanPhenoAbnormal eyelid morphology

MED12L ABCC9 KMT2C CEP152 QRICH1 ANK1 BRCA1 ARID1A NIPBL MED12 SCAF4

1.53e-0314081711HP:0000492
HumanPhenoAplasia/hypoplasia involving bones of the upper limbs

ABCC9 CEP152 RUNX2 BRCA1 ARID1A NIPBL MED12

1.54e-03572177HP:0006496
HumanPhenoBroad nasal tip

TPR ABCC9 QRICH1 ARID1A

1.58e-03159174HP:0000455
HumanPhenoAbnormal nostril morphology

MED12L TPR ABCC9 QRICH1 BRCA1 ARID1A NIPBL

1.58e-03575177HP:0005288
HumanPhenoAplasia involving bones of the extremities

TPR ABCC9 CEP152 RUNX2 BRCA1 ARID1A NIPBL MED12

1.63e-03759178HP:0009825
HumanPhenoAplasia/hypoplasia involving bones of the extremities

TPR ABCC9 CEP152 RUNX2 BRCA1 ARID1A NIPBL MED12

1.66e-03761178HP:0045060
HumanPhenoThick vermilion border

ABCC9 KMT2C BRCA1 ARID1A MED12

1.71e-03279175HP:0012471
HumanPhenoClinodactyly of the 5th finger

TPR CEP152 QRICH1 RUNX2 BRCA1 NIPBL

1.71e-03420176HP:0004209
HumanPhenoClinodactyly of hands

TPR CEP152 QRICH1 RUNX2 BRCA1 NIPBL

1.73e-03421176HP:0001157
HumanPhenoDeviation of the 5th finger

TPR CEP152 QRICH1 RUNX2 BRCA1 NIPBL

1.73e-03421176HP:0009179
MousePhenoembryonic lethality during organogenesis

SP2 BRCA1 ARID1A EP400 RFX3 NIPBL SLC20A1 TCF7L1 MED12 SMC6

2.92e-058763410MP:0006207
MousePhenoembryonic lethality during organogenesis, complete penetrance

SP2 BRCA1 ARID1A EP400 NIPBL SLC20A1 TCF7L1 MED12 SMC6

3.19e-05700349MP:0011098
MousePhenodelayed intramembranous bone ossification

SP3 RUNX2 NIPBL

4.13e-0528343MP:0003420
MousePhenopostnatal growth retardation

ABCC9 KMT2C SP4 RUNX2 ANK1 BRCA1 RFX3 NIPBL SLC20A1

1.89e-04881349MP:0001732
MousePhenoincreased nucleated erythrocyte cell number

RUNX2 ANK1 SLC20A1

1.98e-0447343MP:0009395
MousePhenoabnormal nucleated erythrocyte cell number

RUNX2 ANK1 SLC20A1

2.24e-0449343MP:0012397
MousePhenodecreased birth body size

SP3 RUNX2 ANK1 RFX3 NIPBL

2.27e-04232345MP:0009703
MousePhenoabnormal postnatal growth

ABCC9 KMT2C SP4 RUNX2 ANK1 BRCA1 RFX3 NIPBL SLC20A1

2.35e-04907349MP:0001731
MousePhenoabnormal birth body size

SP3 RUNX2 ANK1 RFX3 NIPBL

2.50e-04237345MP:0009701
MousePhenoabnormal thymus morphology

CIZ1 SP3 SP4 QRICH1 RUNX2 ANK1 BRCA1 CLOCK

2.55e-04717348MP:0000703
MousePhenoschistocytosis

ANK1 SLC20A1

2.55e-0410342MP:0000314
MousePhenodelayed endochondral bone ossification

SP3 RUNX2 NIPBL

3.00e-0454343MP:0003419
MousePhenoabnormal intramembranous bone ossification

SP3 RUNX2 NIPBL

4.30e-0461343MP:0008273
MousePhenospherocytosis

ANK1 SLC20A1

4.40e-0413342MP:0002812
MousePhenoliver hypoplasia

SP3 RUNX2 SLC20A1

4.51e-0462343MP:0000600
DomainSp1_fam

SP2 SP3 SP4

1.26e-0610423IPR030450
DomainMediator_Med12_catenin-bd

MED12L MED12

4.94e-062422IPR021989
DomainMed12-PQL

MED12L MED12

4.94e-062422PF12144
DomainMed12-LCEWAV

MED12L MED12

4.94e-062422PF12145
DomainMediator_Med12

MED12L MED12

4.94e-062422IPR019035
DomainMed12

MED12L MED12

4.94e-062422SM01281
DomainMed12

MED12L MED12

4.94e-062422PF09497
DomainMediator_Med12_LCEWAV

MED12L MED12

4.94e-062422IPR021990
DomainArm_3

KPNA4 KPNA3

1.03e-047422PF16186
DomainImporting_su_alpha

KPNA4 KPNA3

1.03e-047422IPR024931
DomainArm_3

KPNA4 KPNA3

1.03e-047422IPR032413
DomainIBB

KPNA4 KPNA3

1.03e-047422PF01749
Domain-

KPNA4 ARID1A NIPBL MED12 KPNA3

1.35e-042224251.25.10.10
DomainIBB

KPNA4 KPNA3

1.37e-048422PS51214
DomainImportin-a_IBB

KPNA4 KPNA3

1.76e-049422IPR002652
DomainARM-like

KPNA4 ARID1A NIPBL MED12 KPNA3

3.34e-04270425IPR011989
DomainARM-type_fold

KPNA4 USP34 ARID1A NIPBL KPNA3

9.38e-04339425IPR016024
DomainArm

KPNA4 KPNA3

2.20e-0331422PF00514
DomainMYB_LIKE

BDP1 EP400

3.30e-0338422PS50090
DomainARM

KPNA4 KPNA3

3.65e-0340422SM00185
DomainARM_REPEAT

KPNA4 KPNA3

3.65e-0340422PS50176
DomainArmadillo

KPNA4 KPNA3

5.01e-0347422IPR000225
DomainSANT

BDP1 EP400

5.65e-0350422SM00717
DomainSANT/Myb

BDP1 EP400

6.10e-0352422IPR001005
DomainHMG_box

KMT2C TCF7L1

6.33e-0353422PF00505
DomainHMG

KMT2C TCF7L1

6.56e-0354422SM00398
PathwayBIOCARTA_TERC_PATHWAY

NFYA NFYC SP3

2.33e-076333MM1564
PathwayBIOCARTA_TERC_PATHWAY

NFYA NFYC SP3

2.33e-076333M22047
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

NFYA MED15 NFYC CLOCK MED12

7.43e-06118335M27316
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

TPR PHC3 BRCA1 SMC6

2.99e-0577334M27226
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

TPR PHC3 BRCA1 SMC6

4.21e-0584334MM14929
PathwayREACTOME_SUMOYLATION

TPR PHC3 SP3 BRCA1 SMC6

4.22e-05169335MM14919
PathwayREACTOME_SUMOYLATION

TPR PHC3 SP3 BRCA1 SMC6

7.19e-05189335M27214
PathwayREACTOME_NS1_MEDIATED_EFFECTS_ON_HOST_PATHWAYS

KPNA4 TPR KPNA3

1.17e-0441333M29574
PathwayREACTOME_ATF6_ATF6_ALPHA_ACTIVATES_CHAPERONE_GENES

NFYA NFYC

2.36e-0410332M801
PathwayREACTOME_ATF6_ATF6_ALPHA_ACTIVATES_CHAPERONES

NFYA NFYC

3.46e-0412332M794
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

KMT2C ARID1A EP400 CLOCK SUPT7L

3.93e-04272335M29619
PathwayPID_MYC_REPRESS_PATHWAY

NFYA NFYC BRCA1

4.22e-0463333M254
PathwayWP_PATHWAYS_AFFECTED_IN_ADENOID_CYSTIC_CARCINOMA

KMT2C BRCA1 ARID1A

4.62e-0465333M39682
PathwayWP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY

SP3 BRCA1 EP400 TCF7L1 MED12

6.24e-04301335MM15983
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_DEATH_GENES

NFYA NFYC

6.25e-0416332M27940
PathwayREACTOME_ISG15_ANTIVIRAL_MECHANISM

KPNA4 TPR KPNA3

6.77e-0474333M48006
PathwayPID_SMAD2_3NUCLEAR_PATHWAY

MED15 SP3 RUNX2

9.13e-0482333M2
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

NFYA MED15 NFYC KMT2C PHC3 RUNX2 BRCA1 ARID1A TCF7L1 MED12

9.17e-0413873310M734
PathwayREACTOME_ATF4_ACTIVATES_GENES_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS

NFYA NFYC

1.80e-0327332M796
Pubmed

Human transcription factor protein interaction networks.

NFYA MED15 NFYC SP2 KMT2C PHC3 CEP152 QSER1 RASSF8 SMG7 BRCA1 ARID1A EP400 NIPBL SUPT7L SCAF4

5.64e-121429431635140242
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

CIZ1 KPNA4 MED15 NFYC SP2 KMT2C PHC3 ARID1A EP400 KPNA3

4.71e-11398431035016035
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

CIZ1 MED15 TPR KMT2C QSER1 SMG7 ARID1A EP400 MED12 SCAF4

1.06e-09549431038280479
Pubmed

O-GlcNAc modification of Sp3 and Sp4 transcription factors negatively regulates their transcriptional activities.

SP2 SP3 SP4

1.76e-09343326431879
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

KPNA4 USP34 SP2 PHC3 QSER1 ARID1A EP400 CLOCK

1.92e-0928243823667531
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

NFYA CIZ1 NFYC SP2 SP3 SP4 RUNX2 ARID1A CLOCK RFX3 TCF7L1

2.91e-09808431120412781
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

MED15 KMT2C SP4 QRICH1 QSER1 RUNX2 BRCA1 ARID1A EP400 NIPBL MED12 SCAF4

6.04e-091103431234189442
Pubmed

Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia.

SP2 SP3 SP4

7.04e-09443327889927
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

CIZ1 TPR PHC3 QSER1 BRCA1 ARID1A EP400 NIPBL SCAF4 SMC6 KPNA3

1.61e-08954431136373674
Pubmed

Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter.

SP2 SP3 SP4

1.76e-08543310547281
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

CIZ1 KPNA4 MED15 KMT2C PHC3 SP3 BRCA1 EP400 NIPBL MED12 SUPT7L SCAF4 KPNA3

1.81e-081497431331527615
Pubmed

Genetic interaction mapping in mammalian cells using CRISPR interference.

MED15 PHC3 ARID1A EP400 MED12

2.41e-086943528481362
Pubmed

Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells.

SP2 SP3 SP4

3.51e-08643316201967
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

CIZ1 SP2 KMT2C PHC3 QSER1 BRCA1 ARID1A EP400 CLOCK NIPBL SUPT7L SCAF4

3.52e-081294431230804502
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

MED15 QSER1 ARID1A EP400 NIPBL MED12 SUPT7L

3.79e-0826843733640491
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

KPNA4 TPR KMT2C SP3 QRICH1 GJD2 SMG7 NIPBL SLC20A1 MED12 SMC6 KPNA3

4.64e-081327431232694731
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

MED15 USP34 QRICH1 BRCA1 ARID1A EP400 MED12 SMC6

7.58e-0845343829656893
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

MED15 TPR USP34 KMT2C QRICH1 QSER1 SMG7 ARID1A

8.10e-0845743832344865
Pubmed

Interaction network of human early embryonic transcription factors.

MED15 KMT2C QSER1 ARID1A EP400 NIPBL MED12

2.37e-0735143738297188
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

NFYC TPR USP34 KMT2C PHC3 MFAP2 QSER1 SLC20A1 SMC6 KPNA3

6.25e-071084431011544199
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

KPNA4 QRICH1 QSER1 EP400 RFX3 NIPBL MED12

6.72e-0741043726949251
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

CIZ1 USP34 EP400P1 SMG7 BRCA1 ARID1A EP400 TCF7L1 SUPT7L KPNA3

8.13e-071116431031753913
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

KMT2C QSER1 BRCA1 ARID1A EP400

1.03e-0614643523892456
Pubmed

A census of human transcription factors: function, expression and evolution.

NFYA NFYC SP2 SP3 SP4 RUNX2 CLOCK RFX3 TCF7L1

1.38e-0690843919274049
Pubmed

Genetic loss of importin α4 causes abnormal sperm morphology and impacts on male fertility in mouse.

KPNA4 KPNA3

1.49e-06243233058343
Pubmed

Expression Levels of KMT2C and SLC20A1 Identified by Information-theoretical Analysis Are Powerful Prognostic Biomarkers in Estrogen Receptor-positive Breast Cancer.

KMT2C SLC20A1

1.49e-06243227986439
Pubmed

Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection.

KPNA4 KPNA3

1.49e-06243232320654
Pubmed

Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB.

KPNA4 KPNA3

1.49e-06243228179530
Pubmed

Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes.

SP3 SP4

1.49e-0624321454515
Pubmed

Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression.

SP2 SP3

1.49e-0624321341900
Pubmed

Studies on the structure of the mouse CBF-A gene and properties of a truncated CBF-A isoform generated from an alternatively spliced RNA.

NFYA RUNX2

1.49e-0624327509302
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

MED15 KMT2C ARID1A EP400 MED12

2.00e-0616743520362541
Pubmed

Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.

SP3 BRCA1 ARID1A CLOCK

2.57e-067743419505873
Pubmed

cDNAs with long CAG trinucleotide repeats from human brain.

MED15 EP400 MED12

3.06e-06234339225980
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

MED15 TPR USP34 QRICH1 QSER1 EP400 NIPBL MED12 SMC6

3.40e-06101443932416067
Pubmed

Mammalian SP/KLF transcription factors: bring in the family.

SP2 SP3 SP4

3.97e-062543315820306
Pubmed

Loss of MED12 activates the TGFβ pathway to promote chemoresistance and replication fork stability in BRCA-deficient cells.

BRCA1 MED12

4.48e-06343234871431
Pubmed

Subunit association and DNA binding activity of the heterotrimeric transcription factor NF-Y is regulated by cellular redox.

NFYA NFYC

4.48e-0634328910521
Pubmed

Nuclear localization signal in a cancer-related transcriptional regulator protein NAC1.

KPNA4 KPNA3

4.48e-06343222665369
Pubmed

Sp proteins and Runx2 mediate regulation of matrix gla protein (MGP) expression by parathyroid hormone.

SP3 RUNX2

4.48e-06343219306294
Pubmed

Analysis of Sp transcription factors in the postmortem brain of chronic schizophrenia: a pilot study of relationship to negative symptoms.

SP3 SP4

4.48e-06343223540600
Pubmed

Nuclear factor Y (NF-Y) and cellular senescence.

NFYA NFYC

4.48e-06343210585259
Pubmed

Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells.

SP3 SP4

4.48e-06343226967243
Pubmed

Curcumin decreases specificity protein expression in bladder cancer cells.

SP3 SP4

4.48e-06343218593936
Pubmed

Transcriptional regulation of the mouse gene encoding the alpha-4 subunit of the GABAA receptor.

SP3 SP4

4.48e-06343215265862
Pubmed

Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene.

SP3 SP4

4.48e-06343211532028
Pubmed

Histone-fold domain protein NF-Y promotes chromatin accessibility for cell type-specific master transcription factors.

NFYA NFYC

4.48e-06343225132174
Pubmed

The molecular biology of the CCAAT-binding factor NF-Y.

NFYA NFYC

4.48e-06343210571030
Pubmed

Epigenetic role of CCAAT box-binding transcription factor NF-Y on ID gene family in human embryonic carcinoma cells.

NFYA NFYC

4.48e-06343226509926
Pubmed

Karyopherin α 3 and karyopherin α 4 proteins mediate the nuclear import of methyl-CpG binding protein 2.

KPNA4 KPNA3

4.48e-06343226245896
Pubmed

Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.

SP3 SP4

4.48e-06343221919647
Pubmed

Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination.

NFYA NFYC

4.48e-06343223332751
Pubmed

Interaction of tissue transglutaminase with nuclear transport protein importin-alpha3.

KPNA4 KPNA3

4.48e-06343210100610
Pubmed

Zinc finger independent genome-wide binding of Sp2 potentiates recruitment of histone-fold protein Nf-y distinguishing it from Sp1 and Sp3.

SP2 SP3

4.48e-06343225793500
Pubmed

Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3.

SP3 SP4

4.48e-0634327559627
Pubmed

Mediator and cohesin connect gene expression and chromatin architecture.

MED15 NIPBL MED12

5.64e-062843320720539
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

TPR USP34 KMT2C ARID1A MED12

7.66e-0622043535785414
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

NFYA NFYC TPR QRICH1 QSER1 KIF27 EP400 RFX3

8.89e-0685743825609649
Pubmed

Cancer gene mutation frequencies for the U.S. population.

KMT2C ARID1A

8.94e-06443234645806
Pubmed

Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with Crx.

SP3 SP4

8.94e-06443215781457
Pubmed

Importin α3 regulates chronic pain pathways in peripheral sensory neurons.

KPNA4 KPNA3

8.94e-06443232792398
Pubmed

MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection.

KPNA4 KPNA3

8.94e-06443229370303
Pubmed

Prohibitin inhibits tumor necrosis factor alpha-induced nuclear factor-kappa B nuclear translocation via the novel mechanism of decreasing importin alpha3 expression.

KPNA4 KPNA3

8.94e-06443219710421
Pubmed

Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response.

NFYA NFYC

8.94e-06443211158310
Pubmed

NF-Y binding is required for transactivation of neuronal aromatic L-amino acid decarboxylase gene promoter by the POU-domain protein Brn-2.

NFYA NFYC

8.94e-06443211311976
Pubmed

NF-Y recruits Ash2L to impart H3K4 trimethylation on CCAAT promoters.

NFYA NFYC

8.94e-06443221445285
Pubmed

ZBP-89 and Sp3 down-regulate while NF-Y up-regulates SOX18 promoter activity in HeLa cells.

NFYA SP3

8.94e-06443218496767
Pubmed

Transcriptional modulation of the pre-implantation embryo-specific Rnf35 gene by the Y-box protein NF-Y/CBF.

NFYA NFYC

8.94e-06443215516209
Pubmed

Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases.

SP2 SP4

8.94e-06443215788387
Pubmed

Subcellular distribution of importins correlates with germ cell maturation.

KPNA4 KPNA3

8.94e-06443217654710
Pubmed

Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family.

KPNA4 KPNA3

8.94e-0644329395085
Pubmed

Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins.

SP3 SP4

8.94e-06443216574784
Pubmed

Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y).

NFYA NFYC

8.94e-0644329388234
Pubmed

NF-Y affects histone acetylation and H2A.Z deposition in cell cycle promoters.

NFYA NFYC

8.94e-06443221304275
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

CIZ1 FSIP2 PHC3 QSER1 BRCA1 NIPBL SMC6

9.00e-0660843736089195
Pubmed

A protein interaction landscape of breast cancer.

KPNA4 TPR RUNX2 BRCA1 ARID1A SCAF4 KPNA3

1.18e-0563443734591612
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

CIZ1 MED15 CEP152 BRCA1 EP400 MED12 SMC6

1.32e-0564543725281560
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

KPNA4 PHC3 SP3 SP4 EP400 KPNA3

1.43e-0543043635044719
Pubmed

Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.

KMT2C QSER1 NIPBL KPNA3

1.45e-0511943423508102
Pubmed

Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation.

SP3 SP4

1.49e-05543220538607
Pubmed

Interactions between p300 and multiple NF-Y trimers govern cyclin B2 promoter function.

NFYA NFYC

1.49e-05543212482752
Pubmed

Bone morphogenetic protein 2 mediates dentin sialophosphoprotein expression and odontoblast differentiation via NF-Y signaling.

NFYA NFYC

1.49e-05543218424784
Pubmed

Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation.

KMT2C BRCA1

1.49e-05543227653681
Pubmed

Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.

NFYA NFYC

1.49e-05543215831478
Pubmed

Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors.

SP3 SP4

1.49e-05543212560508
Pubmed

Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal.

KPNA4 KPNA3

1.49e-05543219961612
Pubmed

Identification of novel homologues of mouse importin alpha, the alpha subunit of the nuclear pore-targeting complex, and their tissue-specific expression.

KPNA4 KPNA3

1.49e-0554329369227
Pubmed

Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response.

NFYA NFYC

1.49e-05543211256944
Pubmed

Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite.

KPNA4 KPNA3

1.49e-05543217981117
Pubmed

Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system.

SP2 SP4

2.23e-05643214576192
Pubmed

Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import.

KPNA4 KPNA3

2.23e-0564328551560
Pubmed

Differential intranuclear organization of transcription factors Sp1 and Sp3.

SP2 SP3

2.23e-05643215987735
Pubmed

Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway.

NFYA NFYC

2.23e-05643212857729
Pubmed

HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator.

KPNA4 KPNA3

2.23e-0564327859280
Pubmed

Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention.

KPNA4 KPNA3

2.23e-0564328529100
Pubmed

Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors.

KPNA4 KPNA3

2.23e-05643220701745
Pubmed

Phosphorylation of residue 131 of HIV-1 matrix is not required for macrophage infection.

KPNA4 KPNA3

2.23e-0564329008157
Pubmed

p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y.

NFYA NFYC

2.23e-05643214586402
Pubmed

p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells.

KPNA4 KPNA3

2.23e-0564322064827
Pubmed

A synthetic peptide bearing the HIV-1 integrase 161-173 amino acid residues mediates active nuclear import and binding to importin alpha: characterization of a functional nuclear localization signal.

KPNA4 KPNA3

2.23e-05643215037073
InteractionCRX interactions

MED15 NFYC KMT2C SP3 SP4 QRICH1 QSER1 ARID1A EP400 NIPBL MED12

4.14e-122544311int:CRX
InteractionFHL2 interactions

NFYC SP2 PHC3 SP3 SP4 QRICH1 QSER1 RUNX2 BRCA1 EP400 RFX3

4.81e-103964311int:FHL2
InteractionPOLR2H interactions

NFYA NFYC MED12L BDP1 RASSF8 BRCA1 MED12 SCAF4

2.06e-08223438int:POLR2H
InteractionSOX9 interactions

KMT2C PHC3 RUNX2 ARID1A EP400 MED12

5.61e-0897436int:SOX9
InteractionAR interactions

MED15 MED12L TPR USP34 KMT2C QSER1 RUNX2 BRCA1 ARID1A EP400 NIPBL MED12 SUPT7L

8.49e-089924313int:AR
InteractionFEV interactions

SP2 KMT2C PHC3 QSER1 ARID1A EP400 NIPBL

2.25e-07203437int:FEV
InteractionTLE3 interactions

MED15 PHC3 QRICH1 SMG7 ARID1A CLOCK NIPBL SCAF4

1.12e-06376438int:TLE3
InteractionCEBPA interactions

NFYA MED15 KMT2C SP4 QRICH1 QSER1 RUNX2 BRCA1 ARID1A EP400 NIPBL MED12 SCAF4

1.15e-0612454313int:CEBPA
InteractionTERF2IP interactions

CIZ1 KPNA4 PHC3 QSER1 BRCA1 ARID1A EP400 NIPBL SUPT7L

2.00e-06552439int:TERF2IP
InteractionHDAC1 interactions

NFYA KPNA4 NFYC TPR SP3 RUNX2 BRCA1 ARID1A EP400 RFX3 MED12 KPNA3

2.25e-0611084312int:HDAC1
InteractionKLF15 interactions

MED15 NFYC SP2 KMT2C QSER1 EP400 NIPBL

2.46e-06290437int:KLF15
InteractionMED26 interactions

KPNA4 MED15 MED12L MED12 SCAF4

3.15e-06107435int:MED26
InteractionSP7 interactions

KMT2C QSER1 BRCA1 ARID1A EP400 NIPBL SCAF4

3.36e-06304437int:SP7
InteractionMED17 interactions

MED15 MED12L BRCA1 MED12 SUPT7L SCAF4

4.21e-06202436int:MED17
InteractionNUP43 interactions

CIZ1 FSIP2 USP34 PHC3 BRCA1 ARID1A EP400 NIPBL MED12

5.50e-06625439int:NUP43
InteractionSMC5 interactions

CIZ1 TPR PHC3 QSER1 BRCA1 ARID1A EP400 NIPBL SCAF4 SMC6 KPNA3

5.65e-0610004311int:SMC5
InteractionSNRNP40 interactions

CIZ1 PHC3 QRICH1 BRCA1 ARID1A EP400 MED12 SCAF4 KPNA3

6.41e-06637439int:SNRNP40
InteractionNANOG interactions

USP34 KMT2C QSER1 BRCA1 ARID1A EP400 TCF7L1 MED12

6.91e-06481438int:NANOG
InteractionCDK8 interactions

MED15 MED12L BRCA1 NIPBL MED12 SUPT7L

7.24e-06222436int:CDK8
InteractionMKI67 interactions

KPNA4 QRICH1 QSER1 BRCA1 EP400 RFX3 NIPBL MED12 SMC6

7.36e-06648439int:MKI67
InteractionNFIX interactions

KMT2C QRICH1 QSER1 ARID1A EP400 NIPBL

8.23e-06227436int:NFIX
InteractionPAX6 interactions

NFYC KMT2C QRICH1 QSER1 ARID1A EP400 NIPBL

1.13e-05366437int:PAX6
InteractionTP53BP1 interactions

MED15 USP34 BRCA1 ARID1A EP400 MED12 SMC6 KPNA3

1.46e-05533438int:TP53BP1
InteractionCTDSPL2 interactions

KPNA4 MED15 NIPBL KPNA3

1.49e-0570434int:CTDSPL2
InteractionMED13L interactions

MED15 MED12L NIPBL MED12

1.57e-0571434int:MED13L
InteractionRB1 interactions

KPNA4 BDP1 SP3 RUNX2 BRCA1 CLOCK KPNA3

1.82e-05394437int:RB1
InteractionMED23 interactions

MED15 NFYC MED12L EP400 NIPBL MED12

2.02e-05266436int:MED23
InteractionPML interactions

KPNA4 MED15 USP34 SP2 SP3 QRICH1 RUNX2 BRCA1 EP400 SMC6

2.05e-059334310int:PML
InteractionMED21 interactions

MED15 MED12L BRCA1 MED12 SCAF4

2.17e-05159435int:MED21
InteractionKDM1A interactions

TPR USP34 PHC3 CEP152 RASSF8 SMG7 BRCA1 EP400 CLOCK MED12

2.21e-059414310int:KDM1A
InteractionFOXJ2 interactions

NFYC QRICH1 QSER1 RFX3

2.65e-0581434int:FOXJ2
InteractionTNRC6A interactions

KMT2C CEP152 SMG7 BRCA1 ARID1A MED12

2.70e-05280436int:TNRC6A
InteractionSOX2 interactions

KPNA4 USP34 SP2 KMT2C PHC3 QSER1 RUNX2 ARID1A EP400 CLOCK RFX3 NIPBL

2.86e-0514224312int:SOX2
InteractionNUP35 interactions

MED15 USP34 KMT2C QRICH1 QSER1 SMG7 ARID1A

2.91e-05424437int:NUP35
InteractionMED14 interactions

MED15 MED12L MED12 SCAF4 KPNA3

3.08e-05171435int:MED14
InteractionEGR2 interactions

KMT2C QSER1 ARID1A EP400 NIPBL

3.08e-05171435int:EGR2
InteractionMED13 interactions

MED15 MED12L NIPBL MED12

3.36e-0586434int:MED13
InteractionMED12 interactions

MED15 MED12L BRCA1 NIPBL MED12

3.53e-05176435int:MED12
InteractionNFYC interactions

NFYA NFYC SP2 SP4 EP400

3.63e-05177435int:NFYC
InteractionHIF1A interactions

KPNA4 MED15 RUNX2 BRCA1 EP400 MED12 KPNA3

3.74e-05441437int:HIF1A
InteractionMED20 interactions

MED15 MED12L RUNX2 MED12 SCAF4

4.04e-05181435int:MED20
InteractionMED7 interactions

MED15 MED12L EP400 MED12

4.38e-0592434int:MED7
InteractionHIVEP1 interactions

NFYC SP4 QRICH1 SMG7 BRCA1

4.60e-05186435int:HIVEP1
InteractionHNF1B interactions

KMT2C QSER1 ARID1A EP400 NIPBL

5.09e-05190435int:HNF1B
InteractionMYOD1 interactions

KMT2C ARID1A EP400 NIPBL KPNA3

5.61e-05194435int:MYOD1
InteractionKLF5 interactions

KMT2C QSER1 ARID1A EP400 NIPBL

5.75e-05195435int:KLF5
InteractionMED6 interactions

MED15 MED12L MED12 SCAF4

6.31e-05101434int:MED6
InteractionMED10 interactions

MED15 MED12L MED12 SCAF4

6.56e-05102434int:MED10
InteractionMED27 interactions

MED15 MED12L MED12 SCAF4

6.56e-05102434int:MED27
InteractionNFYA interactions

NFYA NFYC QRICH1 BRCA1

7.34e-05105434int:NFYA
InteractionMED1 interactions

MED15 MED12L MED12 SUPT7L SCAF4

7.46e-05206435int:MED1
InteractionMED19 interactions

MED15 MED12L MED12 SCAF4

7.62e-05106434int:MED19
InteractionH3C3 interactions

CIZ1 FSIP2 PHC3 QSER1 BRCA1 NIPBL SMC6

7.74e-05495437int:H3C3
InteractionSP2 interactions

NFYC SP2 QRICH1

7.84e-0539433int:SP2
InteractionMED9 interactions

MED15 MED12L MED12 KPNA3

8.19e-05108434int:MED9
InteractionMRGBP interactions

KPNA4 EP400P1 EP400 KPNA3

8.49e-05109434int:MRGBP
InteractionEN1 interactions

KMT2C QSER1 EP400 NIPBL

8.80e-05110434int:EN1
InteractionPAX8 interactions

KMT2C QSER1 ARID1A NIPBL

9.12e-05111434int:PAX8
InteractionTOP1 interactions

NFYA NFYC TPR BRCA1 ARID1A EP400 NIPBL SCAF4

9.66e-05696438int:TOP1
InteractionKAT5 interactions

KPNA4 TPR BRCA1 EP400 CLOCK KPNA3

1.05e-04358436int:KAT5
InteractionMED28 interactions

MED15 MED12L MED12 SCAF4

1.08e-04116434int:MED28
InteractionTBXT interactions

KMT2C QSER1 ARID1A NIPBL

1.08e-04116434int:TBXT
InteractionSP1 interactions

NFYA NFYC SP2 SP3 SP4 BRCA1

1.17e-04365436int:SP1
InteractionMED16 interactions

MED15 MED12L MED12 SUPT7L

1.23e-04120434int:MED16
InteractionETS1 interactions

RUNX2 BRCA1 ARID1A EP400

1.27e-04121434int:ETS1
InteractionMED8 interactions

MED15 MED12L MED12 SCAF4

1.27e-04121434int:MED8
InteractionSP4 interactions

NFYC SP3 SP4

1.29e-0446433int:SP4
InteractionMED12L interactions

MED15 MED12L MED12

1.37e-0447433int:MED12L
InteractionSMAD2 interactions

MED15 NFYC KMT2C RUNX2 BRCA1 ARID1A

1.57e-04385436int:SMAD2
InteractionPAX9 interactions

KMT2C QSER1 ARID1A NIPBL

1.68e-04130434int:PAX9
InteractionMED15 interactions

MED15 MED12L RUNX2 MED12

1.73e-04131434int:MED15
InteractionASF1A interactions

BDP1 QSER1 BRCA1 ARID1A EP400

1.81e-04249435int:ASF1A
InteractionNKX3-1 interactions

SP2 SP3 SP4

1.86e-0452433int:NKX3-1
InteractionTBP interactions

NFYA NFYC BDP1 SP3 SUPT7L

1.95e-04253435int:TBP
InteractionH2BC8 interactions

CIZ1 PHC3 QSER1 BRCA1 EP400 NIPBL KPNA3

1.98e-04576437int:H2BC8
InteractionKAT2B interactions

NFYA NFYC RUNX2 CLOCK SUPT7L

2.06e-04256435int:KAT2B
InteractionPOU5F1 interactions

NFYC TPR USP34 ARID1A EP400 TCF7L1 KPNA3

2.15e-04584437int:POU5F1
InteractionSRF interactions

NFYA NFYC SP2 PHC3

2.17e-04139434int:SRF
InteractionHMGA2 interactions

NFYA KPNA4 NFYC SP2

2.23e-04140434int:HMGA2
InteractionESRRB interactions

MED15 KMT2C ARID1A EP400 MED12

2.30e-04262435int:ESRRB
InteractionPOGZ interactions

NFYA NFYC SP3 SP4 QRICH1

2.42e-04265435int:POGZ
InteractionCREBBP interactions

NFYA SP3 RUNX2 SMG7 BRCA1 ARID1A CLOCK

2.52e-04599437int:CREBBP
InteractionEMSY interactions

NFYC PHC3 QSER1 BRCA1

2.55e-04145434int:EMSY
InteractionWWTR1 interactions

QSER1 RUNX2 SMG7 ARID1A EP400 CLOCK

2.57e-04422436int:WWTR1
InteractionNCOA1 interactions

RUNX2 SMG7 BRCA1 ARID1A

2.62e-04146434int:NCOA1
InteractionHNF4A interactions

KMT2C QSER1 ARID1A EP400 NIPBL

2.87e-04275435int:HNF4A
InteractionTFAP4 interactions

SP3 BRCA1 ARID1A CLOCK

3.13e-04153434int:TFAP4
InteractionPOLR2K interactions

BDP1 BRCA1 SCAF4 KPNA3

3.29e-04155434int:POLR2K
InteractionFASN interactions

KPNA4 KMT2C GJD2 SMG7 BRCA1 NIPBL SLC20A1 MED12 SMC6

3.37e-041062439int:FASN
InteractionCUX2 interactions

KPNA4 KPNA3

3.42e-0413432int:CUX2
InteractionRAD52 interactions

NFYC BRCA1 KPNA3

3.44e-0464433int:RAD52
InteractionYAP1 interactions

CIZ1 MED15 TPR KMT2C RASSF8 RUNX2 ARID1A MED12 SCAF4

4.22e-041095439int:YAP1
InteractionTP73 interactions

MED15 NFYC SP3 BRCA1

4.56e-04169434int:TP73
InteractionMED11 interactions

MED15 MED12L MED12

4.67e-0471433int:MED11
InteractionRPRD1A interactions

BRCA1 CLOCK SCAF4 KPNA3

5.09e-04174434int:RPRD1A
InteractionTLX1 interactions

KMT2C QSER1 ARID1A NIPBL

5.21e-04175434int:TLX1
InteractionRELA interactions

KPNA4 MED15 IRAK1BP1 SP3 BRCA1 KPNA3

5.39e-04485436int:RELA
InteractionPOLR1G interactions

CIZ1 KPNA4 PHC3 EP400 NIPBL KPNA3

5.63e-04489436int:POLR1G
InteractionPOLR2G interactions

MED15 BRCA1 MED12 SCAF4

5.67e-04179434int:POLR2G
InteractionLHX3 interactions

KMT2C QRICH1 ARID1A NIPBL

6.41e-04185434int:LHX3
Cytoband1q25

TPR SMG7

2.75e-04264321q25
Cytoband12q24.33

EP400P1 EP400

9.40e-044843212q24.33
GeneFamilyZinc fingers C2H2-type|Sp transcription factors

SP2 SP3 SP4

3.10e-079293755
GeneFamilyAtaxins|Trinucleotide repeat containing

MED15 EP400 MED12

8.33e-0625293775
GeneFamilyCyclins|Mediator complex

MED15 MED12L MED12

1.96e-05332931061
GeneFamilyArmadillo repeat containing|Importins

KPNA4 KPNA3

3.74e-0418292596
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

KPNA4 KPNA3

2.15e-0343292409
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

BDP1 EP400

3.25e-0353292532
CoexpressionRIZ_ERYTHROID_DIFFERENTIATION

NFYC SP3 ANK1 BRCA1 CLOCK

2.32e-0782435M16458
CoexpressionRIZ_ERYTHROID_DIFFERENTIATION

NFYC SP3 ANK1 BRCA1 CLOCK

2.78e-0785435MM1106
CoexpressionSENESE_HDAC1_TARGETS_UP

NFYA KPNA4 BDP1 TPR USP34 ABCC9 RASSF8 SMG7

6.18e-07451438M14973
CoexpressionRODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP

KPNA4 TPR USP34 KMT2C QSER1 RUNX2 RFX3 NIPBL SMC6

2.09e-06721439M10237
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

KPNA4 BDP1 TPR USP34 KMT2C PHC3 SP3 RUNX2 ARID1A EP400 NIPBL SLC20A1

3.26e-0614924312M40023
CoexpressionGSE45365_WT_VS_IFNAR_KO_CD8A_DC_MCMV_INFECTION_UP

MED15 SMG7 ARID1A CLOCK SLC20A1

1.83e-05199435M9964
CoexpressionGSE9037_WT_VS_IRAK4_KO_LPS_4H_STIM_BMDM_UP

TPR CLOCK SLC20A1 MED12 SUPT7L

1.87e-05200435M5817
CoexpressionBURTON_ADIPOGENESIS_12

SP3 ARID1A NIPBL

1.97e-0532433MM668
CoexpressionBURTON_ADIPOGENESIS_12

SP3 ARID1A NIPBL

1.97e-0532433M1558
CoexpressionJAK2_DN.V1_DN

PHC3 CEP152 RFX3 SCAF4

9.89e-05147434M2872
CoexpressionGSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN

NFYA QSER1 RUNX2 ANK1

1.04e-04149434M6683
CoexpressionSENESE_HDAC3_TARGETS_UP

NFYA BDP1 TPR USP34 SMG7 RFX3

1.48e-04495436M8451
CoexpressionGSE25146_UNSTIM_VS_HELIOBACTER_PYLORI_LPS_STIM_AGS_CELL_DN

BDP1 TPR NIPBL SLC20A1

1.58e-04166434M8129
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

MED12L KMT2C BRCA1 ARID1A

2.15e-04180434M8239
CoexpressionGSE45365_WT_VS_IFNAR_KO_BCELL_MCMV_INFECTION_UP

TPR USP34 BRCA1 SUPT7L

2.34e-04184434M9988
CoexpressionGSE5099_DAY3_VS_DAY7_MCSF_TREATED_MACROPHAGE_DN

SP3 SP4 ARID1A RFX3

2.34e-04184434M6593
CoexpressionJOHNSTONE_PARVB_TARGETS_2_DN

NFYA USP34 PHC3 RASSF8 RUNX2

2.42e-04344435M2239
CoexpressionGSE29618_PDC_VS_MDC_DAY7_FLU_VACCINE_UP

NFYA RUNX2 SLC20A1 SMC6

3.16e-04199434M4970
CoexpressionGSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN

NFYC TPR SP4 SMG7

3.22e-04200434M4979
CoexpressionGSE21063_WT_VS_NFATC1_KO_8H_ANTI_IGM_STIM_BCELL_DN

KMT2C QSER1 RASSF8 SCAF4

3.22e-04200434M8278
CoexpressionGSE21670_UNTREATED_VS_IL6_TREATED_CD4_TCELL_DN

SP4 ARID1A NIPBL SMC6

3.22e-04200434M7441
CoexpressionAtlasFacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_1000_k-means-cluster#3

BDP1 TPR IRAK1BP1 ABCC9 QSER1 RUNX2 ARID1A NIPBL SLC20A1 SMC6

1.15e-084324310Facebase_RNAseq_e10.5_Maxillary Arch_1000_K3
CoexpressionAtlasFacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#4

BDP1 TPR IRAK1BP1 ABCC9 PHC3 RUNX2 ANK1 ARID1A NIPBL

1.47e-05744439Facebase_RNAseq_e10.5_Medial Nasal Eminence_2500_K4
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_1000_k-means-cluster#1

TPR IRAK1BP1 ABCC9 RUNX2 NIPBL

2.08e-05166435Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_1000_K1
CoexpressionAtlasFacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_1000

BDP1 TPR IRAK1BP1 ABCC9 QSER1 RUNX2 ARID1A NIPBL SLC20A1 SMC6

2.16e-059894310Facebase_RNAseq_e10.5_Maxillary Arch_1000
CoexpressionAtlasfacebase_RNAseq_e10.5_MaxArch_2500_K3

NFYC TPR PHC3 SP3 QSER1 RUNX2 ARID1A RFX3 NIPBL SLC20A1 SMC6

2.87e-0512524311facebase_RNAseq_e10.5_MaxArch_2500_K3
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_LatNas_2500_K3

NFYC BDP1 TPR SP4 QSER1 BRCA1 ARID1A NIPBL SLC20A1 TCF7L1 SMC6

2.97e-0512574311facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_MedNas_2500_K1

TPR SP3 QSER1 BRCA1 ARID1A RFX3 NIPBL SLC20A1 TCF7L1 SMC6

3.91e-0510604310facebase_RNAseq_e10.5_Emin_MedNas_2500_K1
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500_k-means-cluster#3

BDP1 BRCA1 NIPBL SLC20A1 SMC6

4.18e-05192435Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500_K3
CoexpressionAtlasfacebase_RNAseq_e10.5_NeuroEpith_central_2500_K4

NFYC TPR SP2 SP4 BRCA1 ARID1A RFX3 NIPBL SLC20A1 TCF7L1 SMC6

6.53e-0513704311facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_LatNas_2500

NFYC BDP1 TPR SP4 QSER1 BRCA1 ARID1A NIPBL SLC20A1 TCF7L1 SMC6

1.15e-0414594311facebase_RNAseq_e10.5_Emin_LatNas_2500
CoexpressionAtlasFacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#5

BDP1 IRAK1BP1 QSER1 ARID1A NIPBL SLC20A1 SMC6

2.47e-04629437Facebase_RNAseq_e10.5_Maxillary Arch_2500_K5
CoexpressionAtlasFacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_1000_k-means-cluster#4

BDP1 TPR ABCC9 ARID1A NIPBL

3.27e-04298435Facebase_RNAseq_e10.5_Medial Nasal Eminence_1000_K4
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000_k-means-cluster#2

BDP1 BRCA1 NIPBL SLC20A1 SMC6

3.98e-04311435Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000_K2
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_MedNas_2500

TPR SP3 QSER1 BRCA1 ARID1A RFX3 NIPBL SLC20A1 TCF7L1 SMC6

4.20e-0414144310facebase_RNAseq_e10.5_Emin_MedNas_2500
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_500_k-means-cluster#5

BDP1 TPR QSER1 SLC20A1

5.39e-04186434Facebase_RNAseq_e10.5_Mandibular Arch_500_K5
CoexpressionAtlasFacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3

BDP1 SMG7 BRCA1 RFX3 NIPBL SMC6

6.67e-04532436Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
ToppCelldroplet-Limb_Muscle-MUSCLE|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BDP1 TPR USP34 MFAP2 NIPBL SMC6

3.18e-08194436e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BDP1 TPR USP34 KMT2C NIPBL

1.39e-0620043512f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GJD2 RASSF8 RUNX2 ANK1

2.95e-051844342ba98708dfd7f1b2a661578a334684094ff453ad
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

TPR USP34 PHC3 SP3

3.08e-0518643403db813598b67b1e08f759758a1c2023396921fa
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

USP34 KMT2C NIPBL SLC20A1

3.21e-05188434ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellTracheal-10x5prime-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MED12L CEP152 ANK1 BRCA1

3.70e-05195434c96755d2eb98112b703b5dbee9c88730ace7dcbf
ToppCellTCGA-Skin-Metastatic-Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

USP34 ABCC9 PHC3 SP4

3.93e-05198434af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

USP34 ABCC9 PHC3 SP4

3.93e-0519843462cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCellTCGA-Skin-Metastatic|TCGA-Skin / Sample_Type by Project: Shred V9

USP34 ABCC9 PHC3 SP4

3.93e-05198434ad39cce004867f083f8da1954e0cf5a263815184
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

TPR ABCC9 NIPBL SMC6

4.00e-05199434c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell(01)_IL1RL1+-(2)_GFP_FOXI1|(01)_IL1RL1+ / shred by cell type by condition

TPR ABCC9 NIPBL SMC6

4.00e-05199434a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ComputationalNeighborhood of ZNF198

NFYA QSER1 ARID1A KPNA3

2.23e-04117284GCM_ZNF198
ComputationalNeighborhood of DFFA

NFYA CIZ1 ARID1A KPNA3

3.24e-04129284GCM_DFFA
ComputationalNeighborhood of REV3L

TPR BRCA1 EP400

4.44e-0458283MORF_REV3L
DrugSP 0

SP2 SP3 SP4

7.46e-0710433CID002742752
DrugHexamethonium dibromide dihydrate [55-97-0]; Down 200; 10uM; HL60; HG-U133A

SP2 SP3 CEP152 BRCA1 EP400 NIPBL

1.61e-061934361982_DN
Drug2-pyridinecarboxaldehyde N-oxide

SP2 SP3

3.48e-062432CID000556031
Drug6-hydroxyuridine

SP2 SP3

1.04e-053432CID000189012
DrugAC1MJ1BZ

SP2 SP3

1.04e-053432CID003083813
DrugADP-ribosylarginine

SP2 SP3 SP4

1.40e-0525433CID000126311
DrugAC1N3C6T

SP2 SP3

2.09e-054432CID004110181
DrugDicumarol [66-76-2]; Down 200; 11.8uM; PC3; HT_HG-U133A

NFYA TPR PHC3 RASSF8 SMG7

2.65e-051874354323_DN
DrugThioguanosine [85-31-4]; Down 200; 12.6uM; MCF7; HT_HG-U133A

NFYA MED15 TPR CLOCK NIPBL

2.86e-051904352619_DN
DrugCorynanthine hydrochloride [66634-44-4]; Down 200; 10.2uM; MCF7; HT_HG-U133A

NFYA TPR SMG7 BRCA1 SCAF4

2.93e-051914354811_DN
Drug2-propylpentanoic acid; Down 200; 1000uM; MCF7; HT_HG-U133A

NFYA NFYC QSER1 RASSF8 SMG7

3.00e-051924355206_DN
DrugLomefloxacin hydrochloride [98079-52-8]; Down 200; 10.4uM; PC3; HT_HG-U133A

TPR PHC3 SP4 RASSF8 SMG7

3.16e-051944354281_DN
DrugMorantel tartrate [26155-31-7]; Down 200; 10.8uM; MCF7; HT_HG-U133A

NFYA PHC3 CEP152 BRCA1 SUPT7L

3.16e-051944351676_DN
DrugRapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A

TPR USP34 SMG7 ARID1A SCAF4

3.16e-051944351632_UP
DrugMenadione [58-27-5]; Down 200; 23.2uM; PC3; HT_HG-U133A

SMG7 EP400 NIPBL SUPT7L SCAF4

3.16e-051944354662_DN
DrugAndrosterone [53-41-8]; Down 200; 13.8uM; HL60; HT_HG-U133A

USP34 PHC3 SMG7 ARID1A EP400

3.24e-051954351296_DN
DrugTomatidine [77-59-8]; Down 200; 9.6uM; HL60; HG-U133A

CIZ1 USP34 CEP152 MED12 SCAF4

3.24e-051954351754_DN
Drughaloperidol; Down 200; 10uM; MCF7; HT_HG-U133A

NFYA ARID1A EP400 MED12 SUPT7L

3.32e-051964351628_DN
DrugAustricine [10180-88-8]; Down 200; 14.2uM; MCF7; HT_HG-U133A

TPR USP34 PHC3 ARID1A SCAF4

3.40e-051974352812_DN
DrugMepenzolate bromide [76-90-4]; Down 200; 9.6uM; PC3; HT_HG-U133A

TPR USP34 QSER1 ARID1A SCAF4

3.40e-051974353748_DN
DrugThiethylperazine malate [52239-63-1]; Down 200; 6uM; MCF7; HT_HG-U133A

NFYA CIZ1 BRCA1 SUPT7L SCAF4

3.40e-051974356232_DN
DrugFlupentixol dihydrochloride cis-(Z) [2413-38-9]; Down 200; 7.8uM; MCF7; HT_HG-U133A

NFYA PHC3 CEP152 SMG7 BRCA1

3.40e-051974352643_DN
DrugHYCRON linker

KPNA4 KPNA3

3.47e-055432CID011069636
Drugpoly(tetramethylene adipate

SP3 SP4

3.47e-055432CID000032794
Drugfrom Dendrobium nobile

SP2 SP3

3.47e-055432CID000355017
DrugCNI-H0294

KPNA4 KPNA3

3.47e-055432CID000073088
DrugAzacyclonol [115-46-8]; Down 200; 15uM; HL60; HG-U133A

NFYA CIZ1 SMG7 NIPBL MED12

3.48e-051984352020_DN
DrugLaudanosine (R,S) [1699-51-0]; Down 200; 11.2uM; PC3; HT_HG-U133A

MED15 USP34 BRCA1 EP400 SUPT7L

3.48e-051984357270_DN
DrugGly-His-Lys acetate salt; Up 200; 1uM; PC3; HT_HG-U133A

NFYA MED15 TPR USP34 SMG7

3.48e-051984356560_UP
DrugPhentolamine hydrochloride [73-05-2]; Down 200; 12.6uM; HL60; HT_HG-U133A

NFYA USP34 NIPBL MED12 SCAF4

3.48e-051984352362_DN
DrugProparacaine hydrochloride [5875-06-9]; Down 200; 12uM; PC3; HT_HG-U133A

SP2 SMG7 NIPBL MED12 SUPT7L

3.48e-051984356332_DN
DrugConvolamine hydrochloride [500-56-1]; Down 200; 11.8uM; HL60; HG-U133A

NFYA KPNA4 NFYC USP34 SMG7

3.56e-051994351779_DN
DrugSpiperone [749-02-0]; Down 200; 10.2uM; HL60; HG-U133A

NFYA CIZ1 NFYC MED12 SCAF4

3.56e-051994351559_DN
DrugCalycanthine [595-05-1]; Down 200; 11.6uM; MCF7; HT_HG-U133A

NFYA MED15 NFYC NIPBL SCAF4

3.56e-051994356221_DN
DrugEsculetin [305-01-1]; Down 200; 22.4uM; MCF7; HT_HG-U133A

NFYA KPNA4 MED15 SMG7 BRCA1

3.56e-051994356499_DN
DrugEledoisinum

SP2 SP3 SP4

3.60e-0534433CID000006242
DrugPhysalemin

SP2 SP3 SP4

3.94e-0535433CID000017268
Drugshikimic acid-3-phosphate

SP2 SP3

5.20e-056432CID000001095
DrugAC1LA3FM

KPNA4 KPNA3

5.20e-056432CID000480797
Drug2,5-dimethylthiophene

SP2 SP3

5.20e-056432CID000012514
DrugdmDBP

KPNA4 KPNA3

5.20e-056432CID005316801
Drug6-fluoranyl-7H-purine

SP2 SP3

7.27e-057432CID005462117
Drugisobenzofuran

SP2 SP3

7.27e-057432CID011378474
Drug3-(2-carboxyindol-3-yl)propionic acid

SP2 SP3 SP4

7.35e-0543433CID000169313
Drug5,5'-dimethyl-2,2'-bipyridine

SP2 SP3

9.69e-058432CID000015664
DrugHcda

KPNA4 KPNA3

9.69e-058432CID005312573
Druggermyl

SP2 SP3

9.69e-058432CID005460457
DrugADMCs

RUNX2 BRCA1

9.69e-058432CID000077646
Drugdiazinane

SP2 SP3

9.69e-058432CID000136334
Drugpenconazole

TPR TCF7L1

1.24e-049432ctd:C087058
DrugTat11

KPNA4 KPNA3

1.24e-049432CID000480142
DrugD-IBS

SP2 SP3

1.55e-0410432CID000007228
DrugAC1NE2UB

KPNA4 TPR KPNA3

1.62e-0456433CID004635684
Drugboron nitride

SP2 SP3

2.27e-0412432CID000066227
DrugAC1LAPJB

SP2 SP3

2.27e-0412432CID000517869
DrugNSC-350602

SP2 SP3

2.68e-0413432CID006917838
DrugAC1NSKAN

SP2 SP3

3.13e-0414432CID005311244
DrugA-E-C

MFAP2 ARID1A SCAF4

3.14e-0470433CID006438040
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

NFYC QSER1 ARID1A CLOCK

3.15e-041734342881_DN
DrugThimerosal

FSIP2 BDP1 TPR USP34 SP4 RASSF8 EP400 NIPBL TCF7L1

3.36e-041199439ctd:D013849
DrugTrichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

NFYC QRICH1 ARID1A CLOCK

3.51e-04178434992_DN
DrugPhe-gly

KPNA4 SP3 KPNA3

3.56e-0473433CID000098207
DrugAC1L1B35

SP2 SP3 SP4

3.70e-0474433CID000001263
DrugCamptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; MCF7; HT_HG-U133A

NFYA QRICH1 ARID1A NIPBL

3.82e-041824343887_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

NFYC PHC3 CEP152 ARID1A

3.90e-041834343510_DN
DrugIsoconazole [27523-40-6]; Up 200; 9.6uM; MCF7; HT_HG-U133A

NFYA PHC3 GJD2 ARID1A

4.23e-041874347211_UP
DrugHarpagoside [19210-12-9]; Down 200; 8uM; MCF7; HT_HG-U133A

PHC3 CEP152 EP400 SCAF4

4.59e-041914344981_DN
DrugCeforanide [60925-61-3]; Down 200; 7.6uM; MCF7; HT_HG-U133A

CIZ1 MED15 USP34 BRCA1

4.59e-041914345351_DN
DrugPhenformin hydrochloride [834-28-6]; Down 200; 16.6uM; PC3; HT_HG-U133A

TPR USP34 SP4 SMG7

4.59e-041914344283_DN
DrugClotrimazole [23593-75-1]; Down 200; 11.6uM; MCF7; HT_HG-U133A

NFYA BRCA1 ARID1A SCAF4

4.68e-041924346207_DN
DrugPiperine [94-62-2]; Down 200; 14uM; MCF7; HT_HG-U133A

KPNA4 BRCA1 NIPBL SCAF4

4.68e-041924344830_DN
DrugAG-013608 [351320-38-2]; Down 200; 10uM; MCF7; HT_HG-U133A

NFYA TPR RASSF8 SMG7

4.68e-041924346435_DN
DrugKaempferol [520-18-3]; Down 200; 14uM; PC3; HT_HG-U133A

NFYA ARID1A EP400 SCAF4

4.77e-041934345839_DN
DrugHycanthone [3105-97-3]; Down 200; 11.2uM; PC3; HT_HG-U133A

USP34 PHC3 ARID1A SUPT7L

4.77e-041934344630_DN
DrugFenoterol hydrobromide [1944-12-3]; Down 200; 10.4uM; PC3; HT_HG-U133A

CIZ1 TPR USP34 NIPBL

4.77e-041934346331_DN
DrugSpironolactone [52-01-7]; Down 200; 9.6uM; HL60; HG-U133A

NFYA BRCA1 CLOCK NIPBL

4.77e-041934341380_DN
DrugCeforanide [60925-61-3]; Up 200; 7.6uM; MCF7; HT_HG-U133A

CEP152 RASSF8 MED12 SCAF4

4.77e-041934345351_UP
DrugGlibenclamide [10238-21-8]; Down 200; 8uM; HL60; HG-U133A

CIZ1 EP400 NIPBL MED12

4.77e-041934341546_DN
DrugPyridoxine hydrochloride [58-56-0]; Up 200; 19.4uM; HL60; HG-U133A

CIZ1 MED15 EP400 MED12

4.86e-041944341759_UP
Drug2-propylpentanoic acid; Up 200; 50uM; MCF7; HT_HG-U133A_EA

MED15 ARID1A EP400 MED12

4.86e-041944341060_UP
DrugChlortetracycline hydrochloride [64-72-2]; Down 200; 7.8uM; HL60; HG-U133A

CIZ1 SMG7 EP400 NIPBL

4.86e-041944342042_DN
DrugDirithromycin [62013-04-1]; Down 200; 4.8uM; HL60; HG-U133A

NFYA CIZ1 ARID1A MED12

4.86e-041944341712_DN
DrugBuflomedil hydrochloride [35543-24-9]; Down 200; 11.6uM; MCF7; HT_HG-U133A

NFYA CEP152 NIPBL SCAF4

4.86e-041944343274_DN
DrugOzagrel hydrochloride [78712-43-3]; Up 200; 15.2uM; HL60; HT_HG-U133A

CIZ1 ARID1A CLOCK NIPBL

4.96e-041954342942_UP
DrugSTOCK1N-35874; Up 200; 14uM; PC3; HT_HG-U133A

MED15 CEP152 SMG7 BRCA1

4.96e-041954346561_UP
DrugSulfaphenazole [526-08-9]; Down 200; 12.8uM; HL60; HT_HG-U133A

NFYA CIZ1 KPNA4 PHC3

4.96e-041954341836_DN
DrugTamoxifen citrate [54965-24-1]; Down 200; 7uM; PC3; HT_HG-U133A

NFYA KPNA4 NIPBL SUPT7L

4.96e-041954342050_DN
DrugDimaprit dihydrochloride [23256-33-9]; Down 200; 17uM; MCF7; HT_HG-U133A

RASSF8 BRCA1 SUPT7L SCAF4

4.96e-041954347480_DN
DrugClopamide [636-54-4]; Down 200; 11.6uM; HL60; HG-U133A

NFYA CIZ1 ARID1A NIPBL

4.96e-041954341605_DN
DrugMebeverine hydrochloride [2753-45-9]; Down 200; 8.6uM; MCF7; HT_HG-U133A

PHC3 SMG7 SUPT7L SCAF4

4.96e-041954346795_DN
DrugRiboflavine [83-88-5]; Up 200; 10.6uM; MCF7; HT_HG-U133A

PHC3 GJD2 ANK1 SUPT7L

4.96e-041954346822_UP
DrugSTOCK1N-28457; Down 200; 20uM; MCF7; HT_HG-U133A

NFYC USP34 SMG7 SCAF4

4.96e-041954346906_DN
DrugDipivefrin hydrochloride [64019-93-8]; Down 200; 10.4uM; PC3; HT_HG-U133A

TPR BRCA1 TCF7L1 MED12

5.05e-041964347124_DN
DrugMethylprednisolone, 6-alpha [83-43-2]; Down 200; 10.6uM; HL60; HG-U133A

CIZ1 NFYC USP34 MED12

5.05e-041964341567_DN
Drugquercetin dihydrate; Up 200; 1uM; MCF7; HG-U133A

MED15 SMG7 NIPBL MED12

5.05e-04196434283_UP
DrugPiribedil hydrochloride [78213-63-5]; Down 200; 12uM; HL60; HT_HG-U133A

NFYA TPR PHC3 NIPBL

5.05e-041964342951_DN
DrugPiretanide [55837-27-9]; Up 200; 11uM; PC3; HT_HG-U133A

CIZ1 QSER1 SMG7 SUPT7L

5.05e-041964344490_UP
DrugHecogenin [467-55-0]; Down 200; 9.2uM; MCF7; HT_HG-U133A

NFYA NFYC SMG7 SCAF4

5.05e-041964347175_DN
DrugPyridoxine hydrochloride [58-56-0]; Down 200; 19.4uM; MCF7; HT_HG-U133A

MED15 SP2 SUPT7L SCAF4

5.05e-041964342751_DN
DrugSuxibuzone [27470-51-5]; Down 200; 9.2uM; PC3; HT_HG-U133A

NFYA TPR RASSF8 SMG7

5.05e-041964345806_DN
DiseaseKlatskin's tumor (is_implicated_in)

KMT2C ARID1A

1.97e-055422DOID:4927 (is_implicated_in)
Diseaselung non-small cell carcinoma (is_implicated_in)

KMT2C RUNX2 BRCA1 ARID1A

4.59e-05139424DOID:3908 (is_implicated_in)
DiseaseMalignant neoplasm of breast

NFYC ANK1 BRCA1 ARID1A NIPBL TCF7L1 MED12 SMC6

1.18e-041074428C0006142
Diseasestomach cancer (is_implicated_in)

KMT2C BRCA1 ARID1A

1.49e-0472423DOID:10534 (is_implicated_in)
Diseaseprostate carcinoma

KPNA4 PHC3 SP3 CEP152 QSER1 RFX3 SLC20A1

2.40e-04891427EFO_0001663
DiseaseAdenoid Cystic Carcinoma

KMT2C BRCA1 ARID1A

3.94e-04100423C0010606
DiseaseIntrahepatic Cholangiocarcinoma

KMT2C ARID1A

5.35e-0424422C0345905
Diseasestomach carcinoma (is_marker_for)

KMT2C BRCA1

5.35e-0424422DOID:5517 (is_marker_for)
DiseaseExtrahepatic Cholangiocarcinoma

KMT2C ARID1A

5.35e-0424422C3805278
Diseasecancer (implicated_via_orthology)

NFYA PHC3 ARID1A NIPBL

5.68e-04268424DOID:162 (implicated_via_orthology)
DiseaseCholangiocarcinoma

KMT2C ARID1A

6.29e-0426422C0206698
DiseaseBone Diseases, Developmental

ANK1 NIPBL

6.79e-0427422C0005941
DiseaseSezary Syndrome

KMT2C ARID1A

6.79e-0427422C0036920
DiseaseThyroid Gland Follicular Adenoma

TPR TCF7L1

1.14e-0335422C0151468
Diseasecolon cancer (is_implicated_in)

BRCA1 ARID1A

1.21e-0336422DOID:219 (is_implicated_in)
DiseaseThyroid Neoplasm

TPR TCF7L1

1.28e-0337422C0040136

Protein segments in the cluster

PeptideGeneStartEntry
QQQQTTTTSQVQVPQ

EP400

2781

Q96L91
VVSVGTNNVNTFQQE

BDP1

1546

A6H8Y1
GSVQEVAQLQFQLQQ

CEP152

441

O94986
QNAIVNGVLQNTENT

GJD2

146

Q9UKL4
NTFTQVVQGNEFQNI

ANK1

1791

P16157
CQVQRNETQTSGNQI

CDKL4

326

Q5MAI5
IVQRVNETQNGTNNT

ABCC9

321

O60706
QVNLQQFIQQTGTKV

RASSF8

346

Q8NHQ8
TTSVQPQTQQEQQIQ

QRICH1

81

Q2TAL8
QVQVQVQVQQSPQQV

QRICH1

101

Q2TAL8
VQVQQSPQQVSAQLS

QRICH1

106

Q2TAL8
QQQQQLQVTCSAQTV

QRICH1

436

Q2TAL8
VGSVTQLNQQIGQVN

QSER1

636

Q2KHR3
QPQSQQSQQTAYSQQ

ARID1A

581

O14497
SNITAGNQQQVQAVI

KPNA3

351

O00505
VKNEQQQQQQQQFGS

KMT2C

1776

Q8NEZ4
QVLQQQNIQQGSINS

KMT2C

3481

Q8NEZ4
TQSLQQQGVQAENIT

IRAK1BP1

96

Q5VVH5
GLQQTQQQQQTAALV

MED12L

2106

Q86YW9
VNNVVNEFNNAQVTV

FSIP2

4011

Q5CZC0
QSQQAGVSQTTQINR

KIF27

371

Q86VH2
SVVQNQQQISQQGPI

NIPBL

451

Q6KC79
PQVQQQQTAVQTAQA

MED15

361

Q96RN5
QISSIIQGQLVQQQQ

EP400P1

256

Q6ZTU2
GLQQTQQQQQTAALV

MED12

2141

Q93074
QQQIQPITLQNSTQD

PHC3

331

Q8NDX5
QVQGQQQGQQTTSST

NFYC

156

Q13952
QVVQGQIQTLATNAQ

NFYC

261

Q13952
ITQTEVQQGQQQFSQ

NFYC

296

Q13952
TNQTEQNGQVMNITN

BRCA1

536

P38398
TQGQQLQQILQTFQQ

SCAF4

196

O95104
NGNLVQFSQAVSNQI

SLC20A1

356

Q8WUM9
QFQFQSQQQVQQEVI

MFAP2

61

P55001
STEQIVVQAGQIQQQ

NFYA

11

P23511
VVQAGQIQQQQQGGV

NFYA

16

P23511
QIQQQQQGGVTAVQL

NFYA

21

P23511
QIQIQGGQAVQVQGQ

NFYA

111

P23511
QVQGQQGQTQQIIIQ

NFYA

121

P23511
QGQTQQIIIQQPQTA

NFYA

126

P23511
VTAGQTQTQQQIAVQ

NFYA

141

P23511
TQTQQQIAVQGQQVA

NFYA

146

P23511
FNTTGTQVQNITVTQ

MUC17

4296

Q685J3
DVSPVVAAQQQQQQQ

RUNX2

41

Q13950
AQDQSNSLQQVQIVG

SP4

386

Q02446
QLQSGQTIQTIQQQP

SP4

426

Q02446
QQQGQDGVKVQQATI

SP4

561

Q02446
VQQVPVQQQVQQVQT

RFX3

31

P48380
TSQLQVQALTQQQQS

SMG7

756

Q92540
ATAQAQNQQQTEGVK

SUPT7L

81

O94864
LSVTQQQQQQSSQEQ

CLOCK

751

O15516
QQQQQSSQEQQLTSV

CLOCK

756

O15516
QVQTQTYPQVHTQAQ

CIZ1

426

Q9ULV3
LSQTQSQQQVQEAEG

TCF7L1

431

Q9HCS4
VQQQTQATAFVQPTQ

TPR

1766

P12270
SNSQTIQVQPNLTNQ

SP2

141

Q02086
VTITNTGGQQQLTVQ

SP2

451

Q02086
QESQQPTSQAQIVQG

SP3

401

Q02447
QNQENSVNQEIEQFQ

SMC6

421

Q96SB8
EQINQQAQLQEFGQS

USP34

1251

Q70CQ2
SNITAGNQQQVQAVI

KPNA4

351

O00629