Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
HumanPhenoIncreased circulating interleukin 6 concentration

UNC13D CBLB

1.75e-041862HP:0030783
HumanPhenoAbnormal circulating interleukin 6 concentration

UNC13D CBLB

1.75e-041862HP:6000441
HumanPhenoAbnormal lymphocyte physiology

UNC13D CBLB MRTFA STAT6

2.28e-0432864HP:0031409
HumanPhenoAbnormal leukocyte physiology

UNC13D CBLB MRTFA STAT6

2.28e-0432864HP:0033796
HumanPhenoHemophagocytosis

UNC13D CBLB

2.64e-042262HP:0012156
HumanPhenoAbnormal circulating interleukin concentration

UNC13D CBLB

3.15e-042462HP:0030782
DomainCalcineurin-like_Pesterase

MPPED2 MPPED1

1.86e-062262IPR024201
DomainVIT

ITIH2 VWA5B1

8.33e-0510262PS51468
DomainVIT

ITIH2 VWA5B1

8.33e-0510262IPR013694
DomainCalcineurin-like_PHP_ApaH

MPPED2 MPPED1

6.89e-0428262IPR004843
DomainMetallophos

MPPED2 MPPED1

6.89e-0428262PF00149
DomainMetallo-depent_PP-like

MPPED2 MPPED1

7.91e-0430262IPR029052
Domain-

MPPED2 MPPED1

7.91e-04302623.60.21.10
Domain-

ITIH2 VWA5B1

4.73e-03742623.40.50.410
DomainVWFA

ITIH2 VWA5B1

5.78e-0382262PS50234
DomainVWA

ITIH2 VWA5B1

6.06e-0384262SM00327
DomainVWF_A

ITIH2 VWA5B1

8.32e-0399262IPR002035
DomainSH2

CBLB STAT6

1.02e-02110262SM00252
DomainSH2

CBLB STAT6

1.04e-02111262PS50001
DomainSH2

CBLB STAT6

1.05e-02112262IPR000980
Domain-

CBLB STAT6

1.05e-021122623.30.505.10
Pubmed

The 239AB gene on chromosome 22: a novel member of an ancient gene family.

MPPED2 MPPED1

6.25e-0722829266672
Pubmed

E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation.

CBLB STAT6

6.25e-07228224508458
Pubmed

cDNA sequence, genomic organization, and evolutionary conservation of a novel gene from the WAGR region.

MPPED2 MPPED1

6.25e-0722828666403
Pubmed

E3 ubiquitin ligase Cbl-b suppresses human ORMDL3 expression through STAT6 mediation.

CBLB STAT6

1.87e-06328226112603
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

DMTF1 EIF4ENIF1 SPEN MRTFA MDC1

2.19e-0543028535044719
Pubmed

Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7.

TRIM66 ASCL3

7.45e-051628211528127
Pubmed

Global gene expression analysis of murine limb development.

DMTF1 INKA1 STAT6

1.14e-0411728322174793
Pubmed

An improved smaller biotin ligase for BioID proximity labeling.

ZNF318 EIF4ENIF1 MDC1

1.33e-0412328326912792
Pubmed

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

MRTFA MDC1

2.17e-042728217525332
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM66 CMYA5

3.53e-039517259
CoexpressionDAZARD_RESPONSE_TO_UV_NHEK_DN

DMTF1 ZNF318 CBLB SPEN MDC1

1.50e-05300285M8702
CoexpressionGSE19923_WT_VS_E2A_KO_DP_THYMOCYTE_UP

DMTF1 EIF4ENIF1 CYP8B1 ITIH2

5.83e-05200284M7268
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ENOX1 CMYA5 MPPED2 VWA5B1

6.20e-06193284a5695ce2e24a62026ae28f3dea07ca4a435206b8
ToppCelldroplet-Liver-nan-3m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A1BG CYP8B1 ITIH2

1.14e-04151283b4a0546c1573b4b2290890307f2a5daf3a7cbb37
ToppCelldroplet-Liver-nan-3m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A1BG CYP8B1 ITIH2

1.14e-04151283cc9632b58522e2ba3ad36a0b8d37c7c9c8b636c4
ToppCelldroplet-Liver-nan-3m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A1BG CYP8B1 ITIH2

1.14e-041512837758cfbe8dca849c90bd6e8bc63310e53beeb8fd
ToppCelldroplet-Liver-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A1BG CYP8B1 ITIH2

1.16e-041522831febeeb7376e34b9f86c81b2cb1314ee12408864
ToppCelldroplet-Liver-nan-3m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A1BG CYP8B1 ITIH2

1.16e-04152283faa92f7c5a6db9f1eb7d8ec930ba7c8ed9fd1bf1
ToppCellMild-Myeloid-Mast-|Mild / Condition, Lineage, Cell class and cell subclass

MPPED2 VWA5B1 INKA1

1.48e-0416528393d3909a0f5f43d473d5005c842d7d73e25eceed
ToppCellMild-Myeloid-Mast|Mild / Condition, Lineage, Cell class and cell subclass

MPPED2 VWA5B1 INKA1

1.48e-041652835fa9552c37890c5cc7e672a47038aebba2413cb4
ToppCelldroplet-Kidney-nan-3m-Epithelial-Epcam____brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSPOP ITIH2 MPPED1

1.54e-0416728340d102e01ccbc7262d00fafd59ca5234909009cb
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-10|TCGA-Brain / Sample_Type by Project: Shred V9

LRRIQ1 CMYA5 CYP8B1

1.65e-0417128374be8d3bf6b99e2d734635a8b1a7c41e8c596959
ToppCellTCGA-Colorectal-Recurrent_Tumor|TCGA-Colorectal / Sample_Type by Project: Shred V9

CYP8B1 ITIH2 MPPED1

1.76e-041752837f74961436f88c0e380819095e6104489914d765
ToppCellTCGA-Colorectal-Recurrent_Tumor-Colorectal_Adenocarcinoma|TCGA-Colorectal / Sample_Type by Project: Shred V9

CYP8B1 ITIH2 MPPED1

1.76e-04175283bee8f31f036dfcf9fc6ed29156554771a9ee3c60
ToppCellPND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRRIQ1 ASCL3 ITIH2

1.79e-04176283d6d7e4e937d49a5c0d16322c8dd3bf9e97eb8732
ToppCellPND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRRIQ1 ASCL3 ITIH2

1.79e-04176283c03d80df2550c0d2b0452326480d6bf21d20fdd2
ToppCelldroplet-Limb_Muscle-nan-24m-Endothelial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13D SSPOP MDC1

1.85e-04178283f2002a5c4758d0af6c1880ca12f0af0d5e8888e4
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-ependymal_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRIQ1 ASCL3 VWA5B1

1.98e-04182283587636c0f127231de21acd8aa632b74ff22ca8c2
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-Ependyma|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRIQ1 ASCL3 VWA5B1

1.98e-04182283adfadd7893e74b3002f13f00875e3667d3493e0c
ToppCelldroplet-Liver-LIVER_HEP-30m-Lymphocytic-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENOX1 MPPED2 MDC1

2.11e-04186283f5468e03321ea2083e223eb0d92c3a9307039569
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DMTF1 SSH2 CBLB

2.25e-04190283d153a0bdedcd6865e6ee19575234a78b5d859ff1
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CMYA5 MPPED2 VWA5B1

2.28e-041912833e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ENOX1 MPPED2 MPPED1

2.35e-04193283f27e2be497745098b5269aa799dd3d5f62d78ba7
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ENOX1 MPPED2 MPPED1

2.35e-041932834ccf984baebbb13ae916727137ce593fda7514a2
ToppCellRV-02._Fibroblast_II|RV / Chamber and Cluster_Paper

SSH2 CBLB MRTFA

2.39e-0419428311c79a8c56ece42713b04b321982e41e239f07a5
ToppCellLA-02._Fibroblast_II|LA / Chamber and Cluster_Paper

SSH2 CBLB MRTFA

2.39e-04194283234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CMYA5 MPPED2 VWA5B1

2.39e-0419428369bff17df4a760ccf081cf52ff04af02c14f448d
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CMYA5 MPPED2 VWA5B1

2.39e-0419428304bfc555743f7d8821439d05ae442d15e9886c59
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CMYA5 MPPED2 VWA5B1

2.39e-041942834579b4a44f7c731553a284843c296866027d7c0e
ToppCellRV-02._Fibroblast_II|World / Chamber and Cluster_Paper

SSH2 CBLB MRTFA

2.42e-04195283ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CMYA5 MPPED2 VWA5B1

2.42e-041952833d6d3de8ada6dce3dc789c15b50cc066e7100496
ToppCellCOVID-19-Myeloid-Migratory_DC|Myeloid / Condition, Lineage and Cell class

ENOX1 CBLB MPPED2

2.54e-0419828390f3b227cbc61c268d6d94bc9945a08d83d2d3d5
ToppCellBAL-Severe-cDC_10|Severe / Compartment, Disease Groups and Clusters

ENOX1 CBLB MPPED2

2.57e-0419928354bdadd04abaf8caa948b0177c037bc089ca07e6
ToppCellbackground-Hepatocytes|background / Sample and Cell Type and Tumor Cluster (all cells)

A1BG CYP8B1 ITIH2

2.61e-04200283787d35b5c2f2ad967ae14e99496a0299ac7e72fd
Diseasestomach carcinoma (is_marker_for)

CBLB MDC1

2.37e-0424282DOID:5517 (is_marker_for)
Diseasemosquito bite reaction itch intensity measurement

CBLB MPPED1 STAT6

2.47e-04129283EFO_0008377
Diseasemental or behavioural disorder

DMTF1 CMYA5 MRTFA

6.43e-04179283EFO_0000677
DiseaseDiffuse Large B-Cell Lymphoma

SPEN STAT6

1.25e-0355282C0079744
Diseaseage-related hearing impairment

ZNF318 ENOX1 EIF4ENIF1

3.51e-03324283EFO_0005782
Diseaseautism spectrum disorder, schizophrenia

DMTF1 ZNF318 MRTFA

3.60e-03327283EFO_0003756, MONDO_0005090
Diseaseadult onset asthma

UNC13D STAT6

5.60e-03118282EFO_1002011
Diseasevital capacity

TRIM66 UNC13D LRRIQ1 MPPED2 VWA5B1

5.63e-031236285EFO_0004312
DiseaseTinnitus

ZNF318 CBLB

6.75e-03130282HP_0000360
Diseasepulse pressure measurement

TRIM66 UNC13D ZNF318 MPPED2 SSPOP

9.21e-031392285EFO_0005763
Diseaseunipolar depression, bipolar disorder

DMTF1 ENOX1

9.59e-03156282EFO_0003761, MONDO_0004985

Protein segments in the cluster

PeptideGeneStartEntry
EPSPHIHPVDIQMTI

GVINP1

961

Q7Z2Y8
TFPDEIHHPKMTVEP

DMTF1

611

Q9Y222
IEELAAPPPPVLMHH

A1BG

201

P04217
FQPPHVHMVDPIPYD

MPPED2

36

Q15777
MPSRAPVASVPPVHH

INKA1

136

Q96EL1
PGDQHPESPVHTEPM

MDC1

786

Q14676
THPVKTGFPPVHPLM

NMS

81

Q5H8A3
TPPPHVMRVENDPHF

ITIH2

691

P19823
HHVESVPSRDPPMPL

CBLB

576

Q13191
PHVQMVDPVPHDAPK

MPPED1

71

O15442
PEPSPHDLPMDEHVL

LRRIQ1

136

Q96JM4
PFPPHMSPEVEHKEE

CMYA5

546

Q8N3K9
EPMVTFHVHPEAPVS

ASCL3

31

Q9NQ33
RPPSPPAIMHYSEHE

ENOX1

251

Q8TC92
PYLSVHMDPDIHPEP

CYP8B1

386

Q9UNU6
MAAVTVVPPHPVTPA

SSPOP

2361

A2VEC9
CHLTTPIMFPPEHPV

HERC2P3

146

Q9BVR0
HPPSPMDTSELHFVP

MRTFA

856

Q969V6
RPVHQVPLVPHVPMV

EIF4ENIF1

806

Q9NRA8
VPLVPHVPMVRPAHQ

EIF4ENIF1

811

Q9NRA8
IHPEQSVIMPPHSIT

SPEN

3071

Q96T58
TMESHPPIPPVFVEH

SSH2

496

Q76I76
PDMVPQVYPPHSHSI

STAT6

686

P42226
TPPEVPDRGHPHQEM

ZNF205

16

O95201
TPLPEHRSHMVIPAP

PLEKHG2

986

Q9H7P9
IHPAHSFRQPPEMVP

TRIM66

341

O15016
SNHPVPEPHRIMPIT

ZNF318

811

Q5VUA4
MAPEIQPPSHHFSPE

UNC13D

36

Q70J99
RPVEILIHPSEPHMP

VWA5B1

271

Q5TIE3