Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentcell body

PCSK2 AKAP9 MAP1A MTOR VPS13A LRP1 GRIK1 STK39 TANC1 DYNC1H1 PINK1

1.25e-049296511GO:0044297
GeneOntologyCellularComponentdendritic branch

AKAP9 MAP1A

1.98e-047652GO:0044307
GeneOntologyCellularComponentclathrin complex

CLTC VPS41

3.38e-049652GO:0071439
GeneOntologyCellularComponentpostsynaptic endocytic zone

CLTC DNM3

5.14e-0411652GO:0098843
DomainCLH

CLTC VPS41

3.14e-053612SM00299
Domain-

XPO5 MTOR PDS5A PUM3 ECPAS XPOT

8.48e-052226161.25.10.10
DomainRibosomal_S10

MRPS10 DNM3

1.04e-045612IPR001848
DomainARM-type_fold

XPO5 MTOR CLTC PDS5A PUM3 ECPAS XPOT

1.15e-04339617IPR016024
DomainXpo1

XPO5 XPOT

1.56e-046612PF08389
DomainExportin-1/Importin-b-like

XPO5 XPOT

1.56e-046612IPR013598
DomainWD40_repeat_CS

NWD1 UTP15 CORO2A KIF21A GEMIN5

1.96e-04164615IPR019775
DomainClathrin

CLTC VPS41

2.18e-047612PF00637
DomainCHCR

CLTC VPS41

2.18e-047612PS50236
DomainARM-like

XPO5 MTOR PDS5A PUM3 ECPAS XPOT

2.46e-04270616IPR011989
DomainClathrin_H-chain/VPS_repeat

CLTC VPS41

2.90e-048612IPR000547
DomainWD40_repeat_dom

NWD1 UTP15 CORO2A KIF21A VPS41 GEMIN5

4.10e-04297616IPR017986
Domain-

NWD1 UTP15 CORO2A KIF21A VPS41 GEMIN5

7.47e-043336162.130.10.10
DomainWD40/YVTN_repeat-like_dom

NWD1 UTP15 CORO2A KIF21A VPS41 GEMIN5

7.71e-04335616IPR015943
DomainIBN_N

XPO5 XPOT

1.22e-0316612SM00913
DomainImportin-beta_N

XPO5 XPOT

1.38e-0317612IPR001494
DomainHEAT_REPEAT

MTOR PDS5A ECPAS

1.55e-0370613PS50077
DomainWD40

NWD1 UTP15 CORO2A KIF21A GEMIN5

1.56e-03259615PF00400
DomainWD40

NWD1 UTP15 CORO2A KIF21A GEMIN5

1.81e-03268615SM00320
DomainApc4_WD40_dom

NWD1 GEMIN5

1.92e-0320612IPR024977
DomainANAPC4_WD40

NWD1 GEMIN5

1.92e-0320612PF12894
DomainWD40_repeat

NWD1 UTP15 CORO2A KIF21A GEMIN5

1.93e-03272615IPR001680
DomainWD_REPEATS_1

NWD1 UTP15 CORO2A KIF21A GEMIN5

2.12e-03278615PS00678
DomainWD_REPEATS_2

NWD1 UTP15 CORO2A KIF21A GEMIN5

2.16e-03279615PS50082
DomainWD_REPEATS_REGION

NWD1 UTP15 CORO2A KIF21A GEMIN5

2.16e-03279615PS50294
Domain-

MTOR CLTC VPS41 TANC1

4.67e-032076141.25.40.10
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

XPO5 UTP15 ANAPC1 MTOR CLTC GEMIN5 PDS5A PYGL PUM3 ECPAS DYNC1H1 XPOT

2.82e-09653651222586326
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

XPO5 UTP15 GGCT ANAPC1 MTOR CLTC CC2D2A GEMIN5 PDS5A PUM3 ECPAS NCAPH TOP2A DYNC1H1 XPOT

4.31e-081425651530948266
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

MRPS10 TRAPPC11 MAP1A UTP15 MTOR CLTC PDS5A PUM3 NCAPH TOP2A DYNC1H1

7.18e-08704651129955894
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

UTP15 GGCT AAMDC MTOR TECR KIF21A CLTC LRP1 GEMIN5 PYGL STK39 ECPAS NCAPH TOP2A

1.83e-071367651432687490
Pubmed

A protein interaction landscape of breast cancer.

DOCK4 XPO5 GGCT CORO2A CLTC LRP1 PDS5A PUM3 ECPAS TOP2A

2.74e-07634651034591612
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

MRPS10 XPO5 CORO2A MTOR TECR CLTC GEMIN5 PDS5A PUM3 ECPAS NCAPH TOP2A DYNC1H1 XPOT

3.44e-071440651430833792
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

UTP15 GGCT KIF21A CLTC GEMIN5 PDS5A PYGL PUM3 TANC1 NCAPH TOP2A DYNC1H1 XPOT

1.10e-061353651329467282
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

XPO5 ANAPC1 MTOR CLTC GEMIN5 ECPAS

2.21e-0620265633005030
Pubmed

Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.

CSK UTP15 AAMDC PDS5A ECPAS NCAPH XPOT

2.45e-0632365724797263
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

XPO5 MTOR TECR CLTC GEMIN5 PDS5A ECPAS DYNC1H1 XPOT

2.85e-0663865933239621
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

XPO5 ANAPC1 CLTC GEMIN5 PDS5A TOP2A DYNC1H1

2.94e-0633265732786267
Pubmed

The TIP60 Complex Is a Conserved Coactivator of HIF1A.

XPO5 MTOR STK39 ECPAS XPOT

3.15e-0612065527320910
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

GGCT MTOR TECR CLTC PYGL NCAPH TOP2A DYNC1H1 XPOT

3.19e-0664765926618866
Pubmed

Albumin-induced epithelial-mesenchymal transition and ER stress are regulated through a common ROS-c-Src kinase-mTOR pathway: effect of imatinib mesylate.

CSK MTOR

3.44e-06265221367918
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

XPO5 MTOR TECR CLTC VPS13A GEMIN5 PDS5A ECPAS XPOT

3.61e-0665765936180527
Pubmed

LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus.

MRPS10 ALDH1L2 PDS5A PINK1

7.34e-066665436398858
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

XPO5 ANAPC1 CLTC PDS5A ECPAS TOP2A DYNC1H1 XPOT

9.69e-0656065835241646
Pubmed

Condensin confers the longitudinal rigidity of chromosomes.

NCAPH TOP2A

1.03e-05365225961503
Pubmed

Extracellular vesicle-mediated regulation of imatinib resistance in chronic myeloid leukemia via the miR-629-5p/SENP2/PI3K/AKT/mTOR axis.

MTOR SENP2

1.03e-05365239056503
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DOCK4 AKAP9 XPO5 CLTC DNM3 SENP2 DYNC1H1

1.11e-0540765712693553
Pubmed

5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.

MTOR CLTC XPOT

1.76e-052765323027611
Pubmed

Insulin promotes the association of heat shock protein 90 with the inositol 1,4,5-trisphosphate receptor to dampen its Ca2+ release activity.

CSK MTOR

2.06e-05465219147678
Pubmed

The role of c-Src in integrin (α6β4) dependent translational control.

CSK MTOR

2.06e-05465224180592
Pubmed

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

XPO5 GGCT CLTC GIGYF1 NCAPH XPOT

3.03e-0532065628685749
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

MRPS10 XPO5 UTP15 TECR CLTC GEMIN5 PYGL NCAPH TOP2A DYNC1H1 XPOT

3.03e-051318651130463901
Pubmed

Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of Akt.

MTOR HAS2

3.43e-05565222383528
Pubmed

Differential signaling by adaptor molecules LRP1 and ShcA regulates adipogenesis by the insulin-like growth factor-1 receptor.

MTOR LRP1

3.43e-05565221454706
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

XPO5 CLTC PDS5A PYGL PUM3 ZNF770 ECPAS TOP2A DYNC1H1 XPOT

3.63e-051103651034189442
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

MRPS10 XPO5 CORO2A CLTC GEMIN5 PDS5A PYGL ECPAS NCAPH DYNC1H1

5.12e-051149651035446349
Pubmed

Molecular components required for resting and stimulated endocytosis of botulinum neurotoxins by glutamatergic and peptidergic neurons.

CLTC DNM3

5.13e-05665223640057
Pubmed

A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2.

MTOR PINK1

5.13e-05665221177249
Pubmed

A clathrin-dynamin-dependent endocytic pathway for the uptake of HIV-1 by direct T cell-T cell transmission.

CLTC DNM3

5.13e-05665218602423
Pubmed

Association of common variants in/near six genes (ATP2B1, CSK, MTHFR, CYP17A1, STK39 and FGF5) with blood pressure/hypertension risk in Chinese children.

CSK STK39

5.13e-05665223759979
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

MRPS10 GGCT AAMDC KIF21A CLTC GEMIN5 PDS5A NCAPH TOP2A DYNC1H1 XPOT

5.77e-051415651128515276
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

MGAT1 XPO5 MTOR TECR CLTC PDS5A ECPAS DYNC1H1 XPOT

6.20e-0594265931073040
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

CSK CORO2A CES1 DGKK ATP2C2 LRP1 SENP2 STK39

6.38e-0573065834857952
Pubmed

A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.

XPO5 CLTC PDS5A DYNC1H1

7.27e-0511865427377895
Pubmed

Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.

MAP1A GIGYF1 DYNC1H1

7.29e-054365336950384
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

ANAPC1 TECR CLTC GEMIN5 NCAPH TOP2A DYNC1H1

7.42e-0554965738280479
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

MGAT1 XPO5 ANAPC1 TECR CLTC LRP1 GEMIN5 PDS5A TOP2A XPOT

7.50e-051203651029180619
Pubmed

Aire's partners in the molecular control of immunological tolerance.

GEMIN5 TOP2A XPOT

8.36e-054565320085707
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

MRPS10 AKAP9 UTP15 ALDH1L2 TECR CLTC VPS13A SENP2 TANC1 DDHD2 TOP2A

9.48e-051496651132877691
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

CSK XPO5 ANAPC1 KIF21A NCAPH TOP2A DYNC1H1

1.07e-0458265720467437
Pubmed

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

CLTC GEMIN5 TANC1 NCAPH DYNC1H1

1.20e-0425665533397691
Pubmed

CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.

GGCT TECR CLTC LRP1 ECPAS XPOT

1.32e-0441865635338135
Pubmed

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance.

CLTC LRP1

1.53e-041065226005850
Pubmed

Condensins I and II are essential for construction of bivalent chromosomes in mouse oocytes.

NCAPH TOP2A

1.53e-041065221795393
Pubmed

Protein partners of dynamin-1 in the retina.

CLTC DNM3

1.53e-041065223746204
Pubmed

Network organization of the human autophagy system.

TRAPPC11 MAP1A MTOR CLTC ECPAS XPOT

1.68e-0443765620562859
Pubmed

EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.

MTOR CLTC VPS13A ECPAS

1.83e-0415065432423001
Pubmed

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.

CSK XPO5 GGCT CLTC GEMIN5 TOP2A XPOT

1.93e-0464165736057605
Pubmed

Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.

MTOR STK39

2.24e-041265227782176
Pubmed

Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells.

CLTC VPS41

2.24e-041265221411634
Pubmed

Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin.

AKAP9 CSK

2.24e-041265217911601
Pubmed

Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex.

TOP2A DYNC1H1 XPOT

2.39e-046465322865885
Pubmed

Charting the landscape of tandem BRCT domain-mediated protein interactions.

TRAPPC11 ANAPC1 MTOR CLTC GEMIN5 DYNC1H1 XPOT

2.52e-0467065722990118
Pubmed

Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation.

CLTC DNM3

3.08e-041465220802490
Pubmed

Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients.

MTOR ECPAS

3.08e-041465228878358
Pubmed

HSP90 is necessary for the ACK1-dependent phosphorylation of STAT1 and STAT3.

CSK CLTC

3.08e-041465228739485
Pubmed

Characterization of vertebrate cohesin complexes and their regulation in prophase.

ANAPC1 PDS5A

3.08e-041465211076961
Pubmed

BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures.

MTOR DYNC1H1

3.08e-041465222956769
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

CSK XPO5 KIF21A PYGL ECPAS TOP2A

3.38e-0449865636634849
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

XPO5 MTOR KIF21A GEMIN5 PYGL STK39 ECPAS NCAPH DYNC1H1 XPOT

3.50e-041455651022863883
Pubmed

Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach.

XPO5 TECR ECPAS

3.53e-047365323464991
Pubmed

Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.

XPO5 MTOR TECR XPOT

3.91e-0418365423956138
Pubmed

Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.

AKAP9 MAP1A DYNC1H1

3.97e-047665327542412
Pubmed

Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing.

GEMIN5 TOP2A

4.06e-041665216230076
Pubmed

Tagging genes with cassette-exchange sites.

XPO5 UTP15 GEMIN5 TANC1 XPOT

4.14e-0433565515741177
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

AKAP9 ANAPC1 MTOR KIF21A CLTC LRP1 DNM3 DYNC1H1

4.20e-0496365828671696
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

KIF21A AGTR2 CLTC VPS13A PDS5A ECPAS DYNC1H1

4.44e-0473665729676528
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

CSK XPO5 MTOR TECR LRP1 PYGL ECPAS XPOT

4.52e-0497465828675297
Pubmed

RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.

XPO5 CLTC PYGL DYNC1H1 XPOT

4.67e-0434465536282215
Pubmed

Fyn Regulates Binding Partners of Cyclic-AMP Dependent Protein Kinase A.

AKAP9 XPO5 DYNC1H1

4.97e-048265330274258
Pubmed

In vitro nuclear interactome of the HIV-1 Tat protein.

PDS5A PUM3 NCAPH TOP2A

4.97e-0419565419454010
Pubmed

Identification of novel spartin-interactors shows spartin is a multifunctional protein.

CLTC DYNC1H1

5.76e-041965219765186
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

XPO5 ANAPC1 GEMIN5 PDS5A PYGL ECPAS NCAPH TOP2A

5.89e-04101465832416067
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

CORO2A KIF21A CLTC LRP1 DNM3 GRIK1 DYNC1H1 PINK1 XPOT

6.20e-04128565935914814
Pubmed

Identification of Protor as a novel Rictor-binding component of mTOR complex-2.

MTOR CLTC

6.39e-042065217461779
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

XPO5 GGCT TECR KIF21A CLTC GEMIN5 PDS5A DYNC1H1 XPOT

6.63e-04129765933545068
Pubmed

Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.

XPO5 TOP2A DYNC1H1 XPOT

6.67e-0421165417314511
Pubmed

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.

XPO5 ANAPC1 TECR PYGL DYNC1H1 XPOT

6.94e-0457165637167062
Pubmed

Phosphorylation of the chromatin remodeling factor DPF3a induces cardiac hypertrophy through releasing HEY repressors from DNA.

TECR XPOT

7.06e-042165226582913
Pubmed

Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.

TECR CLTC PUM3 NCAPH

7.16e-0421565430462309
Pubmed

Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.

DOCK4 XPO5 TECR ECPAS XPOT

7.58e-0438365529331416
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

XPO5 UTP15 ERI3 CLTC PUM3 TOP2A DYNC1H1

7.64e-0480765722681889
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

XPO5 PDS5A ECPAS XPOT

7.80e-0422065435785414
Pubmed

GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.

ALDH1L2 CLTC TOP2A DYNC1H1

7.93e-0422165429991511
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

DOCK4 MAP1A ANAPC1 AAMDC CLTC TANC1

8.08e-0458865638580884
Pubmed

Rho-associated protein kinase-dependent moesin phosphorylation is required for PD-L1 stabilization in breast cancer.

GGCT MTOR TECR XPOT

8.34e-0422465432941674
Pubmed

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

DOCK4 AKAP9 DDHD2

9.11e-041016539872452
Pubmed

Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human.

LRP1 VWA3B

9.24e-042465217452356
Pubmed

A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.

ANAPC1 DYNC1H1

9.24e-042465233705438
Pubmed

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

KIF21A ATP2C2 PDS5A

9.37e-041026539734811
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

FSIP2 TECR PDS5A PUM3 ZNF770 TOP2A

9.60e-0460865636089195
Pubmed

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.

DOCK4 CSK DNM3

9.64e-0410365321706016
Pubmed

KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer.

CLTC PYGL DYNC1H1

9.92e-0410465336055981
Pubmed

Defects in the cappuccino (cno) gene on mouse chromosome 5 and human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent mechanism.

AGTR2 VPS41

1.00e-032565211110696
Pubmed

Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.

CLTC VPS13A GEMIN5 ECPAS XPOT

1.01e-0340865533766124
Pubmed

The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.

TECR GEMIN5 DYNC1H1 XPOT

1.03e-0323765429564676
Pubmed

The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.

ANAPC1 TANC1 DDHD2

1.05e-0310665331024071
InteractionSIRT7 interactions

XPO5 UTP15 ANAPC1 MTOR CLTC GEMIN5 PDS5A PYGL PUM3 ECPAS TOP2A DYNC1H1 XPOT

4.92e-077446413int:SIRT7
InteractionTNFSF13B interactions

XPO5 MTOR GEMIN5 PDS5A NCAPH XPOT

2.12e-06119646int:TNFSF13B
InteractionGYPA interactions

DOCK4 MTOR DNM3 PDS5A STK39 ECPAS

1.88e-05174646int:GYPA
InteractionP2RY6 interactions

XPO5 MTOR TECR GEMIN5 PDS5A ECPAS NCAPH XPOT

2.87e-05385648int:P2RY6
InteractionLRRC31 interactions

XPO5 ANAPC1 MTOR CLTC GEMIN5 ECPAS

4.72e-05205646int:LRRC31
InteractionHCST interactions

XPO5 MTOR DNM3 PDS5A STK39 ECPAS

4.72e-05205646int:HCST
InteractionFLT3 interactions

XPO5 PDS5A PUM3 ECPAS NCAPH DYNC1H1 XPOT

6.55e-05318647int:FLT3
InteractionFOXB1 interactions

LRP1 PDS5A ECPAS NCAPH DYNC1H1

6.95e-05135645int:FOXB1
InteractionMAPRE3 interactions

DOCK4 AKAP9 MAP1A KIF21A SENP2 TANC1

8.93e-05230646int:MAPRE3
InteractionACP3 interactions

XPO5 MTOR ECPAS PINK1 XPOT

9.13e-05143645int:ACP3
InteractionGBE1 interactions

CSK ALDH1L2 DNM3 PYGL

9.49e-0575644int:GBE1
InteractionHTR3D interactions

CSK HTR3D

9.87e-055642int:HTR3D
InteractionEFNA4 interactions

DOCK4 XPO5 DNM3 PDS5A STK39 XPOT

1.10e-04239646int:EFNA4
InteractionCYP2J2 interactions

CYP2J2 CSK ECPAS

1.17e-0430643int:CYP2J2
Cytoband2q11.2

VWA3B NCAPH FER1L5

1.51e-04726532q11.2
GeneFamilyExportins

XPO5 XPOT

1.15e-047432547
GeneFamilyWD repeat domain containing

NWD1 UTP15 CORO2A KIF21A GEMIN5

3.78e-04262435362
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NWD1 AKAP9 MAP1A CES1 KIF21A CC2D2A VWA3B

1.56e-0819765791637bdeab85024b5a02d1066f76cb803a2d6420
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

AKAP9 KIF21A CLTC PDS5A ZNF770 DYNC1H1

3.86e-07193656abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellNS-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NWD1 MAP1A CES1 KIF21A CC2D2A VWA3B

4.10e-0719565634e37cff4849696ca4ba5dd8fd2cf98fed8bc912
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK2 AKAP9 KIF21A CLTC VPS13A DYNC1H1

4.10e-071956563e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK2 AKAP9 KIF21A CLTC VPS13A DYNC1H1

4.10e-071956567796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NWD1 AKAP9 MAP1A CES1 KIF21A VWA3B

4.35e-0719765622c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NWD1 AKAP9 MAP1A CES1 KIF21A VWA3B

4.35e-071976563bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NWD1 AKAP9 MAP1A CES1 KIF21A VWA3B

4.35e-0719765687db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

VPS13A GEMIN5 ECPAS NCAPH TOP2A

7.33e-06184655a8c6028d745aaa6ee7842259238694cb50ce0526
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

VPS13A GEMIN5 ECPAS NCAPH TOP2A

7.33e-06184655081d045f3bc98a36f342de7d50f39c9a888dd7eb
ToppCellControl-Myeloid_G-immature_Neutrophil|Control / Disease group, lineage and cell class

VPS13A GEMIN5 ECPAS NCAPH TOP2A

7.33e-0618465545f873236f7e90fb78c8e291d3b5b92d121acec9
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

VPS13A GEMIN5 ECPAS NCAPH TOP2A

7.33e-0618465584c20730cd92b9aaa50077d7b625e37e7f9e91d2
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

VPS13A GEMIN5 ECPAS NCAPH TOP2A

7.33e-06184655d31d4116d1d196633784863781fa45673607a421
ToppCellControl-immature_Neutrophil-|Control / Disease condition and Cell class

VPS13A GEMIN5 ECPAS NCAPH TOP2A

7.33e-06184655c4e8ba82a6aa76c46f05a71d5f1c7926555318cf
ToppCellControl-immature_Neutrophil|Control / Disease condition and Cell class

VPS13A GEMIN5 ECPAS NCAPH TOP2A

7.33e-061846552fdae5c6b3eb2232881d933a8c1061fda3623016
ToppCell3'-Distal_airway|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NWD1 CYP2J2 CES1 VWA3B PROS1

9.48e-06194655e9ff4398e880d13894e52c0ba9cf19a7662c248b
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NWD1 MAP1A CES1 CC2D2A VWA3B

9.72e-061956553486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCellmoderate-Epithelial-Ciliated|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NWD1 MAP1A CES1 CC2D2A VWA3B

9.72e-06195655e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCellBL-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NWD1 MAP1A CES1 CC2D2A VWA3B

9.72e-0619565507a6bcef6af93ed87df455dee624037cb75e011a
ToppCellCOVID-19-Epithelial-Ciliated_cells|Epithelial / Condition, Lineage and Cell class

NWD1 MAP1A CES1 KIF21A VWA3B

9.96e-06196655de7aa31354b019d7321a8ef965d59ce2e8b89276
ToppCellNS-moderate-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NWD1 MAP1A CES1 CC2D2A VWA3B

1.02e-0519765571fea4aa6ce96c7693fa94792d08770622873850
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP2J2 CES1 KIF21A CLTC STK39

1.02e-051976555c4cee914baf7cb43e9cb99cc9e3ae823856dc15
ToppCell367C-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

DOCK4 PCSK2 CES1 C6orf163

1.24e-0597654a1279377bf0ee5662db8b9303f5f1fd418dee6df
ToppCell367C-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

DOCK4 PCSK2 CES1 C6orf163

1.24e-059765412cbd03b33e76e5e471bbee2a9c11f27e8b21123
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2-Airway|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK2 CES1 DGKK ATP2C2

3.27e-05124654d88bce8a4f023d5b617b2e8e372a94bd1248d20d
ToppCellfacs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MTOR DNM3 GIGYF1 HAS2

1.04e-04167654528493896aebe7d03d4b6ad2341b12927859e2e4
ToppCellfacs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MTOR DNM3 GIGYF1 HAS2

1.04e-04167654a82e85caf79395baa48380786d9df32a86dfd1ce
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DOCK4 ZNF770 TANC1 ZNF235

1.04e-04167654774f3264318b002d0df5d06d41d645366038d0bf
ToppCell367C-Fibroblasts-Fibroblast-G|367C / Donor, Lineage, Cell class and subclass (all cells)

DOCK4 PCSK2 CES1 C6orf163

1.06e-041686548c95093b1ea45826f62893edd3c410fe53b563a4
ToppCellFetal_29-31_weeks-Epithelial-basal_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

GJB3 NWD1 CYP2J2 CORO2A

1.06e-041686546521bead9789d626b86cbd08692c621c5a5aef33
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VPS41 DNM3 C20orf173 ZNF235

1.06e-0416865432e4d82efaccf336d347e4063253c3635a3ec672
ToppCell367C-Fibroblasts-Fibroblast-G-|367C / Donor, Lineage, Cell class and subclass (all cells)

DOCK4 PCSK2 CES1 C6orf163

1.06e-04168654b8c65542a0701ae31f49d332d87a64578e24b4e3
ToppCellASK440-Immune-B_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

CYP2J2 ALDH1L2 KIF21A NLRP2

1.06e-04168654127559d1a083c68cda9fce143afcc3eec168df17
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GJB3 GGCT CORO2A PYGL

1.09e-04169654305cedbd97059029d7d2a248a8a4b6cfe281aa54
ToppCellControl-T/NK_proliferative|World / Disease group and Cell class

XPO5 TANC1 DDHD2 TOP2A

1.09e-04169654fca735cbb55fce4d32dc6632a39acea1d16b87ab
ToppCellFetal_29-31_weeks-Epithelial-basal_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

GJB3 NWD1 CYP2J2 CORO2A

1.09e-04169654c3ee781735a9288ce1822b230d39bb91c1415589
ToppCell10x5'-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|lymph-node_spleen / Manually curated celltypes from each tissue

NWD1 CES1 LRP1 TOP2A

1.19e-04173654783b8fa08b9d8f597f251793eae164151662f1f9
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP1 PYGL VWA3B TOP2A

1.27e-04176654270d7908dbd84028958d257f94941dc685e20255
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Hematopoietic-Megakaryocytic-Megakaryocyte|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MAP1A DNM3 PYGL PROS1

1.33e-041786542c581a338bf33dbd2be9abe87d0a84f97dfb546f
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MAP1A DNM3 PYGL PROS1

1.33e-041786545caeffb70cbb868586bd260b44ccd3751bbfa615
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Hematopoietic-Megakaryocytic|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MAP1A DNM3 PYGL PROS1

1.33e-04178654afc3220e2319cb38d59307db1b793a3915e1d5c4
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Hematopoietic|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MAP1A DNM3 PYGL PROS1

1.33e-041786544ff23a0bb20c4373db14bfaad18b5fa5c7c78e76
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAP1A CES1 CC2D2A VWA3B

1.39e-041806541f1af4474f3f0ac3c0d6b1a6c875c354d36d8eec
ToppCellControl-Neu_4|World / 5 Neutrophil clusters in COVID-19 patients

VPS13A GEMIN5 ECPAS NCAPH

1.51e-04184654ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CYP2J2 GRIK1 TANC1 HAS2

1.54e-041856542e1766f1a972fecd670daaaf7eb2d3a404f121e7
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NWD1 MAP1A CC2D2A VWA3B

1.54e-041856545e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CYP2J2 GRIK1 TANC1 HAS2

1.54e-041856547aaa8335b40927e3e8fdcede807cd521fc213a0d
ToppCellNS-critical-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NWD1 MAP1A CC2D2A VWA3B

1.57e-0418665476033438426d8f9c72cd6691a7baf92104c9f03d
ToppCell21-Trachea-Epithelial-Intermediate_ciliated|Trachea / Age, Tissue, Lineage and Cell class

NWD1 CES1 CC2D2A VWA3B

1.60e-041876541a2178a195d078d1963947b327c6d0d4f2f48341
ToppCellhuman_hepatoblastoma-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

PCSK2 ATP2C2 TANC1 HAS2

1.64e-04188654b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCellNasal_Brush-Epithelial-Ciliated_2|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

MAP1A CES1 CC2D2A VWA3B

1.71e-041906549ce7df056bfb24d70db4c3c4a2c57d89115de877
ToppCellNasal_Brush-Epithelial-Ciliated_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

MAP1A CES1 CC2D2A VWA3B

1.71e-04190654833481ace2800354712e2ce709d5cdfd0aed3d42
ToppCellHealthy_Control-Epithelial-Epithelial-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

NWD1 KIF21A ATP2C2 VWA3B

1.74e-0419165428caedb2e448e0c7f494100d714fa7cdcf150691
ToppCellHealthy_Control-Epithelial-Epithelial|Healthy_Control / Condition, Lineage, Cell class and cell subclass

NWD1 KIF21A ATP2C2 VWA3B

1.74e-0419165415b9386b26caaa7d15f704c4a18881e1ce918a21
ToppCellHealthy_Control-Epithelial|Healthy_Control / Condition, Lineage, Cell class and cell subclass

NWD1 KIF21A ATP2C2 VWA3B

1.74e-04191654fdcdadbfc9ccae175abe4de8c7428ac4f6a67fde
ToppCellPBMC-Severe-cDC_0|Severe / Compartment, Disease Groups and Clusters

CES1 LRP1 CDYL2 PYGL

1.78e-041926544f4774b925058191673b4ba4b4d05b8b37f61795
ToppCellH1299-infected|H1299 / Cell line, Condition and Strain

AKAP9 VPS13A GIGYF1 TOP2A

1.78e-041926549cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NWD1 CES1 ATP2C2 VWA3B

1.81e-04193654ea345d34440b25f65358a53dc72831998d1c3620
ToppCellBronchial_Biopsy-Epithelial-Ciliated_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

MAP1A CES1 VWA3B PROS1

1.81e-041936540b62a6ddd7c42efd9f39781971d1438501e1fa8d
ToppCellBronchial_Brush-Epithelial-Ciliated_1|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

NWD1 CES1 CC2D2A VWA3B

1.85e-04194654b4ce60c06568123008b1081d644733cb91c28f51
ToppCellNS-critical-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NWD1 MAP1A CC2D2A VWA3B

1.85e-041946541ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCellASK452-Epithelial-Ciliated|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

NWD1 KIF21A CC2D2A VWA3B

1.85e-041946545aeb44657ab6f61b1abf98af28d3397d8e44c1aa
ToppCellTCGA-Thryoid-Primary_Tumor|TCGA-Thryoid / Sample_Type by Project: Shred V9

GJB3 GGCT CORO2A PROS1

1.88e-041956547cdee2ae90edf15e4cbcf70797b8caf1f037b0ef
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma|TCGA-Thryoid / Sample_Type by Project: Shred V9

GJB3 GGCT CORO2A PROS1

1.88e-04195654b61b8c931bd0ca3678486653ae1d7e9915c696c7
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NWD1 CES1 VWA3B PROS1

1.92e-04196654a37ba02446eef5d1fab703204583f6550a8ec3e1
ToppCellsaliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-ciliated_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CYP2J2 CES1 KIF21A ATP2C2

1.92e-04196654d9426eba69047166ffa8179f1654e011c1020328
ToppCell10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_monocytic-classical_monocyte|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MGAT1 CES1 CLTC LRP1

1.92e-0419665428e9e191361966df3a9bd48450090577aa72a999
ToppCellcritical-Epithelial-Ciliated|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NWD1 MAP1A CC2D2A VWA3B

1.92e-0419665427b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NWD1 CES1 VWA3B PROS1

1.92e-04196654a156840330630e518bc85633dded6f2c3ead3b30
ToppCellsaliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-ciliated_cell-Epi-Ciliated|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CYP2J2 CES1 KIF21A ATP2C2

1.92e-041966547e19919eafd6ddf547dd4e8aa532a050e182c5cc
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NWD1 CES1 VWA3B PROS1

1.92e-0419665489ea4d2086e1c769c5a87f1471a6cd4acabcfe33
ToppCellNS-critical-d_07-13-Epithelial-Ciliated-diff|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

AKAP9 CES1 KIF21A CC2D2A

1.96e-0419765432484fb5dde0a4525dd8028dde01ca5a4e51e4b6
ToppCellNS-critical-d_0-4-Epithelial-Ciliated-diff|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NWD1 MAP1A CES1 KIF21A

1.96e-0419765462e20ef825b92908d7732aa625dcff7b95ef6ca8
ToppCellcritical-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NWD1 MAP1A CC2D2A VWA3B

2.00e-04198654ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCellCaecum-(6)_Macrophage-(61)_LYVE1_Macrophage|Caecum / shred on region, Cell_type, and subtype

DOCK4 NWD1 LRP1 PYGL

2.00e-04198654e684c3934c163aef4d284b69435832d2c9614f2a
ToppCellCaecum-Macrophage-LYVE1_Macrophage|Caecum / Region, Cell class and subclass

DOCK4 NWD1 LRP1 PYGL

2.00e-04198654a92c0cacb775aca6bbb302bd9e22c081a112a44d
ToppCellproximal-Epithelial-Differentiating_Basal-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GJB3 CYP2J2 KIF21A ATP2C2

2.04e-04199654c607346f60e5997e757e5a31cab412ab3734377b
ToppCellproximal-3-Epithelial-Differentiating_Basal|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GJB3 CYP2J2 KIF21A ATP2C2

2.04e-0419965412e07084fc2d5d4c418df564ccc0e132b056e549
ToppCellproximal-Epithelial-Differentiating_Basal|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GJB3 CYP2J2 KIF21A ATP2C2

2.04e-0419965496a89a2578fad9a99c52d2cf9e26e06516a96568
ToppCell343B-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

DOCK4 AKAP9 CES1 TANC1

2.04e-04199654212e89d097753790061310373a1fafba773488b6
ToppCell343B-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

DOCK4 AKAP9 CES1 TANC1

2.04e-0419965414b676aa289c0578a37be32cec3ea285c79d97cc
ToppCell(10)_Ciliated|World / shred by cell type by condition

NWD1 MAP1A CC2D2A VWA3B

2.08e-042006541b6a8025bd2746b626040058c122b1be3ab2fa61
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

DOCK4 AKAP9 LRP1 HAS2

2.08e-042006549b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

GGCT TECR LRP1 HAS2

2.08e-04200654ab4fda0cc95cb8f80ea9f28745013f3248def820
ToppCellControl_saline-Mesenchymal_fibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

DOCK4 NAALAD2 LRP1 HAS2

2.08e-0420065464ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCellNS-moderate-d_0-4-Epithelial|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

AKAP9 CES1 KIF21A ATP2C2

2.08e-0420065464462a18afca3c1a8548a857924b8166058bf958
ToppCellControl-Control-Myeloid-immature_Neutrophil|Control / Disease, condition lineage and cell class

VPS13A GEMIN5 NCAPH TOP2A

2.08e-04200654118321ac443feb42aee171baccfc4610f00a8822
ToppCellmyeloid-pro-cDC|myeloid / Lineage and Cell class

GGCT TECR NCAPH TOP2A

2.08e-042006544aa2308eeb94e0bdff4e02eb9e45ba8837ae14bf
ToppCellmLN-Macrophage-LYVE1_Macrophage|Macrophage / Region, Cell class and subclass

AKAP9 TECR LRP1 DYNC1H1

2.08e-04200654e3c15e0e1c2602b0cc9ab8cc50c978d265350c94
ToppCell(09)_Interm._secr.>cil.|World / shred by cell type by condition

NWD1 MAP1A CC2D2A VWA3B

2.08e-042006543305e14dba12e94da42f0414fdc7a2c8caf0a183
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts|Control_saline / Treatment groups by lineage, cell group, cell type

DOCK4 NAALAD2 LRP1 HAS2

2.08e-04200654a1fc74c1b27e104895910bc7cdce7ba33d30df7e
Diseasebeta-citrylglutamate measurement

NAALAD2 HTR3D

9.66e-057642EFO_0800060
Diseasecerebellar ataxia (implicated_via_orthology)

VPS13A GEMIN5

1.29e-048642DOID:0050753 (implicated_via_orthology)
Diseasecongenital diaphragmatic hernia (implicated_via_orthology)

AGTR2 LRP1

3.01e-0412642DOID:3827 (implicated_via_orthology)
Diseasechronic kidney disease (implicated_via_orthology)

PCSK2 AGTR2

3.01e-0412642DOID:784 (implicated_via_orthology)
DiseaseMalformations of Cortical Development

MTOR DYNC1H1

4.14e-0414642C1955869
DiseaseCortical Dysplasia

MTOR DYNC1H1

4.14e-0414642C0431380
Diseasestatus epilepticus (implicated_via_orthology)

MTOR GRIK1

9.47e-0421642DOID:1824 (implicated_via_orthology)
Diseasemyocardial infarction (is_implicated_in)

PCSK2 CYP2J2 LRP1

1.32e-0399643DOID:5844 (is_implicated_in)
DiseaseLeft Ventricular Hypertrophy

MTOR AGTR2

1.35e-0325642C0149721
Diseaselung small cell carcinoma (is_implicated_in)

XPO5 MTOR

1.69e-0328642DOID:5409 (is_implicated_in)
Diseaseintellectual disability (is_implicated_in)

AGTR2 CC2D2A

1.94e-0330642DOID:1059 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
IASLSWGQMKVKGSN

AAMDC

6

Q9H7C9
WPKNGLLDMNKGLSL

ERI3

286

O43414
GQLDQKTAMSLLWKS

CES1

371

P23141
RLSKIWGQQTDGMKL

AKAP9

1276

Q99996
FKKNGLIMSSGQAWK

CYP2J2

121

P51589
INWTLIMGDKKAGFS

ALDH1L2

141

Q3SY69
KKIGIWNSNSGLNMT

GRIK1

416

P39086
QWSAGIALMKNILGF

AGTR2

206

P50052
KNSQLKTLLAIGGWN

CHIA

86

Q9BZP6
SGWALNMKELKLLQT

CSK

186

P41240
LLSIAKQLGIMTNWK

C6orf163

261

Q5TEZ5
LIGWSQGKQLLSMFT

ATP2C2

311

O75185
LWSSATGKLQGKQHM

NWD1

1026

Q149M9
LLVRWLLGMKNNQSK

PDS5A

841

Q29RF7
GMKNLKSWASVNRGA

PUM3

586

Q15397
AGNMVIWSKGSKSQA

ANAPC1

96

Q9H1A4
NSRLKNKMWYGLLGT

DGKK

886

Q5KSL6
NKMWYGLLGTKELLQ

DGKK

891

Q5KSL6
MQKWAGNSKAKTGIV

MAP1A

216

P78559
WAGLAKQGLSMKTLL

GIGYF1

761

O75420
MLKKQSAGLVLWGAI

MGAT1

1

P26572
KLLGMQQESRLWKLG

GGNBP1

41

Q5YKI7
LGKATALAIMGDKLW

LRP1

1786

Q07954
NLSMSLWGKNKNITV

FSIP2

3986

Q5CZC0
WLTISNIGIMKGGSK

DNM3

531

Q9UQ16
LQSQSWKMKAQGAIA

ECPAS

1536

Q5VYK3
NLKLDKMVGWLLQQS

PINK1

521

Q9BXM7
LKNNLLGSLRMAWKS

DDHD2

586

O94830
GVVWKMNKSNLNSLD

GGCT

81

O75223
GLGKTTLAQKLMLDW

NLRP2

216

Q9NX02
FLSLGKKAWLLMGNA

CC2D2A

1376

Q9P2K1
TKLTQNGDMLDLLKW

DOCK4

576

Q8N1I0
LGNLKKLMSTGTSRW

CORO2A

231

Q92828
KMFAIATINKAGWGT

HAS2

451

Q92819
LVNDNWKLGMNKRSL

GLYATL1B

181

A0A0U1RQE8
SGSGKSMAWRVLLKA

DYNC1H1

2226

Q14204
GMNSGSELGKLWRKL

C20orf173

51

Q96LM9
MDWKTLQALLSGVNK

GJB3

1

O75712
LLNWRLMDTNTKGNK

MTOR

2426

P42345
GSWNNMLKLGNKSPN

SENP2

111

Q9HC62
VWDMLKGGQLLVSLK

UTP15

231

Q8TED0
AKNGGLLLSTNMKWV

MRPS10

31

P82664
WGLRNMKKASSPQLL

FER1L5

1251

A0AVI2
KGAKLGNAAWAMATS

TANC1

1266

Q9C0D5
RSWNLMKQGASGIKE

PROS1

451

P07225
GIKKSGMATENLWLS

HTR3D

106

Q70Z44
MLKQLWSSSKGLDSL

CDYL2

481

Q8N8U2
AVWSQLAKAQLQKGM

CLTC

1106

Q00610
KLKQSMWSLLTALSG

NCAPH

646

Q15003
TKWIKKQMSNGAFSG

PRSS45P

226

Q7RTY3
MGLLSQRKWTLSGSQ

nan

1

Q8N2B8
QLSLGIWKGAVALKN

VPS13A

26

Q96RL7
LKTGWMNKHLNLVPA

TRAPPC11

81

Q7Z392
MWDLKRFQSTGKLTG

KIF21A

1476

Q7Z4S6
MLWKGDLKGVLQTAA

GEMIN5

926

Q8TEQ6
WLFTSVLKGLQMHGQ

XPO5

1071

Q9HAV4
SLVGFTQMTIWAKGK

TECR

271

Q9NZ01
TGGKKLLLFERSWMN

VPS41

146

P49754
LTLPFSWQNMGKNLK

ZNF770

406

Q6IQ21
SWQNMGKNLKGILTT

ZNF770

411

Q6IQ21
WLLGMLGAESAKLNN

TOP2A

1036

P11388
NGMGQSLIVSWSKLI

XPOT

296

O43592
SLNMLKGPWGLSDQK

VWA3B

746

Q502W6
KDELWLVMKLLSGGS

STK39

131

Q9UEW8
KAWNTMVLKNIAASG

PYGL

796

P06737
LWMKELQTQRGKHSG

ZNF235

66

Q14590
QEIARSFGKLMSKGW

NAALAD2

386

Q9Y3Q0
KGVLKEWTLMLHGTQ

PCSK2

581

P16519