Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

PLEKHG1 ARHGAP22 ARHGEF28 ARHGAP31 IQSEC1 TBC1D22B ARHGEF2 SIPA1L2 ARHGAP21

1.91e-05507609GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

PLEKHG1 ARHGAP22 ARHGEF28 ARHGAP31 IQSEC1 TBC1D22B ARHGEF2 SIPA1L2 ARHGAP21

1.91e-05507609GO:0030695
GeneOntologyMolecularFunctionmicrotubule plus-end binding

CLASP1 APC CLASP2

3.81e-0522603GO:0051010
GeneOntologyMolecularFunctiondystroglycan binding

CLASP1 CLASP2

5.75e-0412602GO:0002162
GeneOntologyMolecularFunctionJUN kinase kinase kinase activity

MAP3K9 MAP3K10

5.75e-0412602GO:0004706
GeneOntologyMolecularFunctionenzyme regulator activity

PLEKHG1 ARHGAP22 ARHGEF28 ARHGAP31 IQSEC1 APC TBC1D22B ARHGEF2 SIPA1L2 ARHGAP21 SLX4 RECK

9.04e-0414186012GO:0030234
GeneOntologyMolecularFunctionGTPase activator activity

ARHGAP22 ARHGAP31 TBC1D22B SIPA1L2 ARHGAP21

1.50e-03279605GO:0005096
GeneOntologyMolecularFunctiontubulin binding

SETD2 CLASP1 KIF26B APC CLASP2 ARHGEF2

1.76e-03428606GO:0015631
GeneOntologyBiologicalProcessnegative regulation of microtubule depolymerization

CLASP1 APC CLASP2 ARHGEF2

4.74e-0638614GO:0007026
GeneOntologyBiologicalProcessregulation of small GTPase mediated signal transduction

PLEKHG1 ARHGAP22 ARHGEF28 ARHGAP31 IQSEC1 ARHGEF2 SIPA1L2 ARHGAP21

5.94e-06333618GO:0051056
GeneOntologyBiologicalProcessregulation of microtubule depolymerization

CLASP1 APC CLASP2 ARHGEF2

7.12e-0642614GO:0031114
GeneOntologyBiologicalProcessnegative regulation of microtubule polymerization or depolymerization

CLASP1 APC CLASP2 ARHGEF2

1.56e-0551614GO:0031111
GeneOntologyBiologicalProcessmicrotubule depolymerization

CLASP1 APC CLASP2 ARHGEF2

4.35e-0566614GO:0007019
GeneOntologyBiologicalProcesspositive regulation of basement membrane assembly involved in embryonic body morphogenesis

CLASP1 CLASP2

8.55e-055612GO:1904261
GeneOntologyBiologicalProcessregulation of basement membrane assembly involved in embryonic body morphogenesis

CLASP1 CLASP2

8.55e-055612GO:1904259
GeneOntologyBiologicalProcessnegative regulation of wound healing, spreading of epidermal cells

CLASP1 CLASP2

8.55e-055612GO:1903690
GeneOntologyBiologicalProcessbasement membrane assembly involved in embryonic body morphogenesis

CLASP1 CLASP2

8.55e-055612GO:2001197
GeneOntologyBiologicalProcessnegative regulation of protein depolymerization

CLASP1 APC CLASP2 ARHGEF2

1.40e-0489614GO:1901880
GeneOntologyBiologicalProcesssmall GTPase-mediated signal transduction

PLEKHG1 ARHGAP22 ARHGEF28 ARHGAP31 IQSEC1 ARHGEF2 SIPA1L2 ARHGAP21

1.78e-04538618GO:0007264
GeneOntologyBiologicalProcessnegative regulation of protein-containing complex disassembly

CLASP1 APC CLASP2 ARHGEF2

2.20e-04100614GO:0043242
GeneOntologyBiologicalProcessregulation of protein depolymerization

CLASP1 APC CLASP2 ARHGEF2

2.65e-04105614GO:1901879
GeneOntologyBiologicalProcessregulation of microtubule polymerization or depolymerization

CLASP1 APC CLASP2 ARHGEF2

2.95e-04108614GO:0031110
GeneOntologyBiologicalProcessestablishment of mitotic spindle localization

CLASP1 CLASP2 ARHGEF2

2.99e-0444613GO:0040001
GeneOntologyBiologicalProcesspositive regulation of extracellular matrix disassembly

CLASP1 CLASP2

3.81e-0410612GO:0090091
GeneOntologyBiologicalProcessregulation of basement membrane organization

CLASP1 CLASP2

4.65e-0411612GO:0110011
GeneOntologyBiologicalProcessregulation of wound healing, spreading of epidermal cells

CLASP1 CLASP2

4.65e-0411612GO:1903689
GeneOntologyBiologicalProcessbasement membrane assembly

CLASP1 CLASP2

5.57e-0412612GO:0070831
GeneOntologyCellularComponentanchoring junction

USP53 ARHGAP22 ANK2 CLASP1 ARHGAP31 PKP3 TRPC4 APC CLASP2 ARHGEF2 ARHGAP21 TJP3

1.76e-059766012GO:0070161
GeneOntologyCellularComponentcortical microtubule cytoskeleton

CLASP1 CLASP2

8.06e-055602GO:0030981
GeneOntologyCellularComponentbasal cortex

CLASP1 CLASP2

1.69e-047602GO:0045180
GeneOntologyCellularComponentglutamatergic synapse

ARHGAP22 NSMF TENM3 IQSEC1 APC CLASP2 ARHGEF2 SIPA1L2 BEGAIN

5.03e-04817609GO:0098978
GeneOntologyCellularComponentcortical cytoskeleton

NSMF CLASP1 TRPC4 CLASP2

5.17e-04129604GO:0030863
GeneOntologyCellularComponentbicellular tight junction

USP53 APC ARHGEF2 TJP3

5.47e-04131604GO:0005923
GeneOntologyCellularComponentcell cortex

NSMF CLASP1 TRPC4 FRMPD1 APC CLASP2

6.70e-04371606GO:0005938
GeneOntologyCellularComponenttight junction

USP53 APC ARHGEF2 TJP3

6.84e-04139604GO:0070160
GeneOntologyCellularComponentWnt signalosome

APC RECK

9.47e-0416602GO:1990909
GeneOntologyCellularComponentapical junction complex

USP53 APC ARHGEF2 TJP3

1.10e-03158604GO:0043296
GeneOntologyCellularComponentcell-cell junction

USP53 ANK2 PKP3 TRPC4 APC ARHGEF2 TJP3

1.47e-03591607GO:0005911
GeneOntologyCellularComponentkinetochore microtubule

CLASP1 CLASP2

1.80e-0322602GO:0005828
GeneOntologyCellularComponentkinetochore

CENPC CLASP1 APC CLASP2

1.82e-03181604GO:0000776
GeneOntologyCellularComponentcondensed chromosome, centromeric region

CENPC CLASP1 APC CLASP2

2.29e-03193604GO:0000779
GeneOntologyCellularComponentmitotic spindle

MYF6 LIMK2 CLASP1 CLASP2

2.66e-03201604GO:0072686
GeneOntologyCellularComponentruffle

APC CLASP2 SAMSN1 ARHGEF2

2.90e-03206604GO:0001726
GeneOntologyCellularComponentmicrotubule plus-end

CLASP1 CLASP2

2.92e-0328602GO:0035371
GeneOntologyCellularComponentruffle membrane

APC CLASP2 ARHGEF2

3.71e-03108603GO:0032587
GeneOntologyCellularComponentmicrotubule

CLASP1 DYNC2H1 KIF26B APC CLASP2 ARHGEF2

4.17e-03533606GO:0005874
GeneOntologyCellularComponentmicrotubule end

CLASP1 CLASP2

5.33e-0338602GO:1990752
GeneOntologyCellularComponentcytoplasmic microtubule

CLASP1 APC CLASP2

6.61e-03133603GO:0005881
GeneOntologyCellularComponentchromosomal region

CENPC CLASP1 APC CLASP2 SLX4

7.13e-03421605GO:0098687
GeneOntologyCellularComponentaxonal growth cone

APC CLASP2

7.41e-0345602GO:0044295
GeneOntologyCellularComponentcell cortex region

CLASP1 CLASP2

7.41e-0345602GO:0099738
GeneOntologyCellularComponentfocal adhesion

ARHGAP22 CLASP1 ARHGAP31 CLASP2 ARHGEF2

7.85e-03431605GO:0005925
GeneOntologyCellularComponentchromosome, centromeric region

CENPC CLASP1 APC CLASP2

8.13e-03276604GO:0000775
GeneOntologyCellularComponentpostsynaptic density, intracellular component

IQSEC1 ARHGEF2

8.74e-0349602GO:0099092
GeneOntologyCellularComponentcell-substrate junction

ARHGAP22 CLASP1 ARHGAP31 CLASP2 ARHGEF2

8.78e-03443605GO:0030055
DomainMLK1/MLK2/MLK4

MAP3K9 MAP3K10

5.47e-054572IPR016231
DomainCLASP_N

CLASP1 CLASP2

5.47e-054572PF12348
DomainCLASP_N_dom

CLASP1 CLASP2

5.47e-054572IPR024395
DomainMAP3K10

MAP3K9 MAP3K10

5.47e-054572IPR015785
DomainPDZ

LIMK2 FRMPD1 SIPA1L2 ARHGAP21 TJP3

6.98e-05141575PF00595
DomainPDZ

LIMK2 FRMPD1 SIPA1L2 ARHGAP21 TJP3

8.77e-05148575SM00228
Domain-

LIMK2 FRMPD1 SIPA1L2 ARHGAP21 TJP3

9.35e-051505752.30.42.10
DomainPDZ

LIMK2 FRMPD1 SIPA1L2 ARHGAP21 TJP3

9.65e-05151575PS50106
DomainPDZ

LIMK2 FRMPD1 SIPA1L2 ARHGAP21 TJP3

9.95e-05152575IPR001478
DomainSH3_2

MAP3K9 MAP3K10 SAMSN1 TJP3

1.37e-0486574IPR011511
DomainSH3_2

MAP3K9 MAP3K10 SAMSN1 TJP3

1.37e-0486574PF07653
DomainPH

PLEKHG1 ARHGAP22 ARHGEF28 IQSEC1 ARHGEF2 ARHGAP21

1.98e-04278576SM00233
DomainPH_DOMAIN

PLEKHG1 ARHGAP22 ARHGEF28 IQSEC1 ARHGEF2 ARHGAP21

2.02e-04279576PS50003
DomainPH_domain

PLEKHG1 ARHGAP22 ARHGEF28 IQSEC1 ARHGEF2 ARHGAP21

2.06e-04280576IPR001849
DomainPH_dom-like

PLEKHG1 ARHGAP22 ARHGEF28 FRMPD1 IQSEC1 ARHGEF2 ARHGAP21

3.02e-04426577IPR011993
DomainRhoGAP

ARHGAP22 ARHGAP31 ARHGAP21

8.97e-0462573SM00324
DomainRhoGAP

ARHGAP22 ARHGAP31 ARHGAP21

9.40e-0463573PF00620
DomainDH_1

PLEKHG1 ARHGEF28 ARHGEF2

9.40e-0463573PS00741
DomainRHOGAP

ARHGAP22 ARHGAP31 ARHGAP21

9.84e-0464573PS50238
DomainRhoGAP_dom

ARHGAP22 ARHGAP31 ARHGAP21

9.84e-0464573IPR000198
Domain-

ARHGAP22 ARHGAP31 ARHGAP21

9.84e-04645731.10.555.10
DomainPost-SET_dom

SETD2 SETD1B

1.07e-0316572IPR003616
DomainPostSET

SETD2 SETD1B

1.07e-0316572SM00508
DomainPOST_SET

SETD2 SETD1B

1.07e-0316572PS50868
DomainRhoGEF

PLEKHG1 ARHGEF28 ARHGEF2

1.17e-0368573SM00325
Domain-

PLEKHG1 ARHGAP22 ARHGEF28 IQSEC1 ARHGEF2 ARHGAP21

1.19e-033915762.30.29.30
DomainRhoGEF

PLEKHG1 ARHGEF28 ARHGEF2

1.28e-0370573PF00621
DomainDH_2

PLEKHG1 ARHGEF28 ARHGEF2

1.28e-0370573PS50010
DomainDH-domain

PLEKHG1 ARHGEF28 ARHGEF2

1.33e-0371573IPR000219
Domain-

PLEKHG1 ARHGEF28 ARHGEF2

1.33e-03715731.20.900.10
DomainRho_GTPase_activation_prot

ARHGAP22 ARHGAP31 ARHGAP21

2.46e-0388573IPR008936
DomainArm

PKP3 APC

4.02e-0331572PF00514
DomainSH3

MAP3K9 MAP3K10 SAMSN1 TJP3

4.26e-03216574SM00326
DomainSH3

MAP3K9 MAP3K10 SAMSN1 TJP3

4.26e-03216574PS50002
DomainSH3_domain

MAP3K9 MAP3K10 SAMSN1 TJP3

4.54e-03220574IPR001452
Domain-

CLASP1 PKP3 APC CLASP2

4.69e-032225741.25.10.10
DomainPH

PLEKHG1 ARHGAP22 ARHGEF2 ARHGAP21

5.23e-03229574PF00169
DomainGDS_CDC24_CS

PLEKHG1 ARHGEF2

6.31e-0339572IPR001331
DomainARM_REPEAT

PKP3 APC

6.63e-0340572PS50176
DomainARM

PKP3 APC

6.63e-0340572SM00185
DomainSET

SETD2 SETD1B

6.95e-0341572PF00856
DomainSer-Thr/Tyr_kinase_cat_dom

LIMK2 MAP3K9 MAP3K10

8.63e-03138573IPR001245
DomainSET

SETD2 SETD1B

8.69e-0346572SM00317
DomainArmadillo

PKP3 APC

9.06e-0347572IPR000225
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

PLEKHG1 ARHGAP22 LIMK2 ARHGEF28 CENPC CLASP1 ARHGAP31 CLASP2 ARHGEF2 ARHGAP21 GOLGA3

9.33e-067204411M41838
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

PLEKHG1 ARHGAP22 ARHGEF28 CENPC CLASP1 ARHGAP31 CLASP2 ARHGEF2 ARHGAP21 GOLGA3

2.39e-056494410MM15690
PathwayREACTOME_RHOA_GTPASE_CYCLE

ARHGAP22 ARHGEF28 ARHGAP31 ARHGEF2 ARHGAP21

7.65e-05142445MM15576
PathwayREACTOME_RHOA_GTPASE_CYCLE

ARHGAP22 ARHGEF28 ARHGAP31 ARHGEF2 ARHGAP21

9.61e-05149445M41805
PathwayREACTOME_CDC42_GTPASE_CYCLE

PLEKHG1 ARHGAP22 ARHGAP31 ARHGAP21

2.05e-0494444MM15598
PathwayREACTOME_ROLE_OF_ABL_IN_ROBO_SLIT_SIGNALING

CLASP1 CLASP2

2.63e-048442M27351
PathwayREACTOME_RHO_GTPASE_CYCLE

PLEKHG1 ARHGAP22 ARHGEF28 ARHGAP31 ARHGEF2 ARHGAP21 GOLGA3

3.83e-04439447MM15595
PathwayREACTOME_RHO_GTPASE_CYCLE

PLEKHG1 ARHGAP22 ARHGEF28 ARHGAP31 ARHGEF2 ARHGAP21 GOLGA3

4.44e-04450447M27078
PathwayKEGG_MEDICUS_REFERENCE_MLK_JNK_SIGNALING_PATHWAY

MAP3K9 MAP3K10

6.16e-0412442M47929
PathwayKEGG_MEDICUS_REFERENCE_LESION_BYPASS_BY_TLS_AND_DSB_FORMATION

REV3L SLX4

9.74e-0415442M47854
PathwayREACTOME_RHOB_GTPASE_CYCLE

ARHGEF28 ARHGEF2 ARHGAP21

1.29e-0369443MM15596
PathwayREACTOME_RHOB_GTPASE_CYCLE

ARHGEF28 ARHGEF2 ARHGAP21

1.34e-0370443M41806
PathwayREACTOME_CDC42_GTPASE_CYCLE

PLEKHG1 ARHGAP22 ARHGAP31 ARHGAP21

1.36e-03155444M41808
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

USP53 PLEKHG1 LIMK2 HIVEP1 ARHGEF28 CLASP1 KIF26B IQSEC1 APC KDM3B MAP3K9 MAP3K10 TBC1D22B CLASP2 ARHGEF2 SIPA1L2 OBI1 ARHGAP21

6.82e-15861621836931259
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

UIMC1 SETD2 RAD18 HIVEP1 SETD1B CLASP1 DYNC2H1 APC ZNF318 SIPA1L2 OBI1 SLX4 PAPOLG

3.15e-11588621338580884
Pubmed

Role of CLASP2 in microtubule stabilization and the regulation of persistent motility.

CLASP1 APC CLASP2

5.38e-08562317113391
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

CLASP1 KIF26B APC CLASP2 SIPA1L2 ARHGAP21 GOLGA3

9.51e-0820962736779422
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

UIMC1 SETD2 RAD18 HIVEP1 CLASP1 PKP3 IQSEC1 KDM3B ZNF318 ARHGEF2 PAPOLG

1.12e-07774621115302935
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

ANK2 CLASP1 TRPC4 HECTD4 IQSEC1 APC CLASP2 ZNF318 ARHGEF2 ARHGAP21 GOLGA3 BEGAIN

1.15e-07963621228671696
Pubmed

Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.

ANK2 CLASP1 CLASP2 ARHGAP21

5.78e-073762427565344
Pubmed

EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis.

CLASP1 APC CLASP2

6.42e-071062323001180
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

SETD2 SETD1B HECTD4 APC NKTR ZNF318 ARHGEF2 SLX4

1.15e-0644062834244565
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

SETD2 RAD18 CLASP1 PKP3 IQSEC1 KDM3B CLASP2 OBI1 ARHGAP21 BEGAIN TJP3

2.01e-061038621126673895
Pubmed

A human MAP kinase interactome.

USP53 HIVEP1 ARHGAP31 KIF26B APC MAP3K10 NKTR OBI1

2.40e-0648662820936779
Pubmed

Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function.

CLASP1 CLASP2

3.13e-06262216914514
Pubmed

Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis.

SETD2 APC

3.13e-06262228825595
Pubmed

Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics.

CLASP1 CLASP2

3.13e-06262212837247
Pubmed

The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis.

MAP3K9 MAP3K10

3.13e-06262211416147
Pubmed

Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment.

CLASP1 CLASP2

3.13e-06262216866869
Pubmed

Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains.

MAP3K9 MAP3K10

3.13e-0626228477742
Pubmed

Golgi-derived CLASP-dependent microtubules control Golgi organization and polarized trafficking in motile cells.

CLASP1 CLASP2

3.13e-06262219701196
Pubmed

Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2.

MAP3K9 MAP3K10

3.13e-0626228536694
Pubmed

Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization.

CLASP1 CLASP2

3.13e-06262210899121
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PLEKHG1 SETD1B TENM3 CLASP1 FRMPD1 SIPA1L2 ARHGAP21

8.07e-0640762712693553
Pubmed

CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development.

CLASP1 CLASP2

9.37e-06362228285824
Pubmed

Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype.

MAP3K9 MAP3K10

9.37e-06362218414056
Pubmed

Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network.

CLASP1 CLASP2

9.37e-06362217543864
Pubmed

CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta.

CLASP1 CLASP2

9.37e-06362216824950
Pubmed

Plakophilin3 loss leads to increased adenoma formation and rectal prolapse in APCmin mice.

PKP3 APC

9.37e-06362234823217
Pubmed

CLIPs and CLASPs and cellular dynamics.

CLASP1 CLASP2

9.37e-06362215928712
Pubmed

Molecular determinants of polyubiquitin recognition by continuous ubiquitin-binding domains of Rad18.

UIMC1 RAD18

9.37e-06362225756347
Pubmed

Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity.

MAP3K9 MAP3K10

9.37e-0636228195146
Pubmed

CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment.

CLASP1 CLASP2

9.37e-06362222307330
Pubmed

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

CLASP1 FRMPD1 IQSEC1 APC SIPA1L2 ARHGAP21 BEGAIN

1.15e-0543062732581705
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

PLEKHG1 CLASP1 APC TBC1D22B CLASP2 ARHGEF2 SIPA1L2

1.46e-0544662724255178
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

NSMF ANK2 HECTD4 APC MAP3K10 REV3L ANKRD6 ARHGAP21 SLX4 RECK GOLGA3

1.51e-051285621135914814
Pubmed

SOGA1 and SOGA2/MTCL1 are CLASP-interacting proteins required for faithful chromosome segregation in human cells.

CLASP1 CLASP2

1.87e-05462233587225
Pubmed

RAD18 transmits DNA damage signalling to elicit homologous recombination repair.

UIMC1 RAD18

1.87e-05462219396164
Pubmed

The membrane-anchored MMP-regulator RECK is a target of myogenic regulatory factors.

MYF6 RECK

1.87e-05462216007210
Pubmed

Expression of the histone lysine methyltransferases SETD1B, SETDB1, SETD2, and CFP1 exhibits significant changes in the oocytes and granulosa cells of aged mouse ovaries.

SETD2 SETD1B

1.87e-05462235445296
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

RAD18 FRMPD1 APC MAP3K9 PHTF2 CLASP2 ZNF318 ANKRD6 ARHGAP21 SLX4

2.05e-051084621011544199
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PLEKHG1 SETD1B HECTD4 KDM3B CLASP2 REV3L ARHGEF2 SIPA1L2 ARHGAP21 TJP3

2.41e-051105621035748872
Pubmed

CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex.

CLASP1 CLASP2

3.12e-05562215631994
Pubmed

Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5β complex in migrating cells.

CLASP1 CLASP2

3.12e-05562227378169
Pubmed

Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts.

CLASP1 CLASP2

3.12e-05562211290329
Pubmed

CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover.

CLASP1 CLASP2

3.12e-05562224859005
Pubmed

Epiblast integrity requires CLASP and Dystroglycan-mediated microtubule anchoring to the basal cortex.

CLASP1 CLASP2

3.12e-05562223940118
Pubmed

The human immunoglobulin kappa locus. Characterization of the duplicated O regions.

IGKV2D-40 IGKV2-40

3.12e-0556221907917
Pubmed

Host PDZ-containing proteins targeted by SARS-CoV-2.

SIPA1L2 ARHGAP21 TJP3

3.39e-053562333864728
Pubmed

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

CLASP1 HECTD4 CLASP2 ARHGEF2

3.41e-051026249734811
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

ANK2 IQSEC1 APC ARHGEF2 SIPA1L2 BEGAIN

3.63e-0534762617114649
Pubmed

SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.

PKP3 IQSEC1 APC ARHGEF2 OBI1 GOLGA3

3.99e-0535362627545878
Pubmed

An EB1-binding motif acts as a microtubule tip localization signal.

APC CLASP2

4.67e-05662219632184
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

IQSEC1 ZNF318 REV3L ARHGEF2 SLX4

4.88e-0522262537071664
Pubmed

ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.

APC CLASP2

6.53e-05762220937854
Pubmed

Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks.

UIMC1 RAD18

6.53e-05762222742833
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

TENM3 APC KDM3B TBC1D22B CLASP2 ZNF318 ARHGAP21 GOLGA3

6.98e-0577762835844135
Pubmed

Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.

NSMF CLASP1 CLASP2 ARHGAP21

8.28e-0512862430995482
Pubmed

The leukotriene receptors as therapeutic targets of inflammatory diseases.

OXGR1 APC

8.69e-05862231135881
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

HIVEP1 APC ZNF318 OBI1 ARHGAP21 GOLGA3

1.01e-0441862634709266
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

APC TBC1D22B ZNF318 SIPA1L2 ARHGAP21

1.08e-0426362534702444
Pubmed

Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex.

MAP3K9 MAP3K10

1.12e-04962214504284
Pubmed

Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron.

PAX8 APC

1.12e-04962225647637
Pubmed

ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity.

CLASP1 CLASP2

1.39e-041062218854161
Pubmed

MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.

CLASP1 CLASP2 ARHGEF2

1.47e-045762329089450
Pubmed

New nomenclature for chromatin-modifying enzymes.

SETD2 SETD1B KDM3B

1.47e-045762318022353
Pubmed

Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.

PLEKHG1 HIVEP1

1.70e-041162222488850
Pubmed

EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.

PKP3 APC CLASP2

1.98e-046362329162697
Pubmed

An Interaction Landscape of Ubiquitin Signaling.

UIMC1 RAD18 HECTD4 KDM3B ARHGEF2 SLX4

2.17e-0448162628190767
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

RAD18 PKP3 APC ARHGEF2 OBI1 BEGAIN

2.75e-0450362616964243
Pubmed

Neurocalcin Delta Knockout Impairs Adult Neurogenesis Whereas Half Reduction Is Not Pathological.

APC MAP3K10

2.81e-041462230853885
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

SETD2 CLASP1 APC KDM3B CLASP2 ARHGEF2 PAPOLG

3.23e-0473362734672954
Pubmed

MAP3Ks as central regulators of cell fate during development.

MAP3K9 MAP3K10

3.23e-041562218855897
Pubmed

Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method.

ARHGEF28 DYNC2H1

3.23e-041562212056414
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

SETD2 TENM3 CLASP1 DYNC2H1

3.54e-0418762426460568
Pubmed

Modifier genes in mice and humans.

APC HPS5

3.69e-041662211256068
Pubmed

Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.

HECTD4 APC ARHGEF2 ARHGAP21

3.76e-0419062415161933
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

USP53 UIMC1 HIVEP1 DYNC2H1 APC KDM3B CLASP2 ARHGEF2

4.02e-04100562819615732
Pubmed

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.

ANK2 IQSEC1 MAP3K10 BEGAIN

4.31e-0419762436604605
Pubmed

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.

UIMC1 PKP3 APC ZNF318 ARHGAP21

4.67e-0436162530344098
Pubmed

Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.

PLEKHG1 TENM3

4.70e-041862224058526
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

SETD2 ARHGEF28 SETD1B CENPC OXGR1 CLASP2 NKTR OBI1 PAPOLG

5.48e-04132762932694731
Pubmed

Phosphoproteome analysis of the human mitotic spindle.

RAD18 NSMF CENPC ARHGEF2

5.48e-0421062416565220
Pubmed

Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis.

RAD18 SLX4

7.06e-042262222902628
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

UIMC1 RAD18 HIVEP1 CENPC KDM3B PAPOLG

7.47e-0460862636089195
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

CLASP1 IQSEC1 CLASP2 BEGAIN

7.82e-0423162416452087
Pubmed

Proximity interactions among centrosome components identify regulators of centriole duplication.

CLASP1 IQSEC1 NKTR

7.94e-0410162324613305
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

SETD2 LIMK2 RAD18 IQSEC1 ZNF318 REV3L SIPA1L2 IQCM

7.98e-04111662831753913
Pubmed

Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.

PKP3 APC ARHGAP21

8.17e-0410262315778465
Pubmed

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

FRMPD1 ANKRD6 HPS5

8.17e-0410262310231032
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

TENM3 TBC1D22B SIPA1L2 ARHGAP21 GOLGA3

9.32e-0442162536976175
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

ANK2 CLASP1 IQSEC1 APC CLASP2 ARHGEF2 SIPA1L2 ARHGAP21 GOLGA3

9.37e-04143162937142655
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

WDR64 HIVEP1 DYNC2H1 KDM3B REV3L ARHGEF2

9.58e-0463862631182584
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

RAD18 CENPC CLASP1 APC CLASP2 OBI1 SLX4 BEGAIN

9.96e-04115562820360068
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

ARHGEF28 APC KDM3B ARHGEF2 HPS5 ARHGAP21

1.05e-0365062638777146
Pubmed

Novel genes differentially expressed in cortical regions during late neurogenesis.

TENM3 TBC1D22B

1.15e-032862217614941
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

UIMC1 KDM3B ZNF318 SLX4 PAPOLG

1.18e-0344462534795231
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

PLEKHG1 ARHGAP22 ARHGEF28 ARHGAP31 NKTR ARHGEF2 ARHGAP21

1.20e-0391662732203420
Pubmed

Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors.

MAP3K9 SIPA1L2

1.23e-032962224105743
Pubmed

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.

ARHGAP22 HIVEP1 GOLGA3

1.24e-0311862321078624
Pubmed

C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.

CLASP2 OBI1 GOLGA3

1.28e-0311962335776542
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

UIMC1 SETD2 ANK2 KDM3B ZNF318 SIPA1L2 ARHGAP21

1.34e-0393462733916271
Pubmed

An improved smaller biotin ligase for BioID proximity labeling.

MUC19 ZNF318 HPS5

1.40e-0312362326912792
InteractionYWHAH interactions

USP53 PLEKHG1 HIVEP1 ARHGEF28 CLASP1 KIF26B HECTD4 APC KDM3B MAP3K9 MAP3K10 TBC1D22B CLASP2 NKTR SAMSN1 ARHGEF2 SIPA1L2 ARHGAP21

3.11e-0911026218int:YWHAH
InteractionYWHAG interactions

USP53 PLEKHG1 HIVEP1 ARHGEF28 CLASP1 KIF26B HECTD4 IQSEC1 APC KDM3B MAP3K9 MAP3K10 TBC1D22B CLASP2 NKTR SAMSN1 ARHGEF2 SIPA1L2 ARHGAP21

3.22e-0912486219int:YWHAG
InteractionSFN interactions

USP53 ARHGEF28 CLASP1 KIF26B PKP3 APC MAP3K10 CLASP2 SAMSN1 ARHGEF2 SIPA1L2 OBI1 ARHGAP21

1.45e-076926213int:SFN
InteractionYWHAB interactions

HIVEP1 ARHGEF28 CLASP1 KIF26B HECTD4 APC MAP3K9 MAP3K10 TBC1D22B CLASP2 SAMSN1 ARHGEF2 SIPA1L2 ARHGAP21

1.84e-0610146214int:YWHAB
InteractionYWHAE interactions

RAD18 HIVEP1 ARHGEF28 CLASP1 KIF26B APC MAP3K9 MAP3K10 TBC1D22B CLASP2 SAMSN1 ARHGEF2 SIPA1L2 ARHGAP21 GOLGA3

4.43e-0612566215int:YWHAE
InteractionYWHAZ interactions

HIVEP1 ARHGEF28 CLASP1 KIF26B HECTD4 APC MAP3K9 MAP3K10 TBC1D22B CLASP2 SAMSN1 ARHGEF2 SIPA1L2 ARHGAP21 GOLGA3

8.01e-0613196215int:YWHAZ
InteractionNUP43 interactions

SETD2 HIVEP1 SETD1B CENPC MUC19 APC NKTR ZNF318 HPS5 SLX4

1.92e-056256210int:NUP43
InteractionSYNGAP1 interactions

USP53 ANK2 IQSEC1 ARHGEF2 SIPA1L2 ARHGAP21 BEGAIN

4.27e-05307627int:SYNGAP1
InteractionMAPRE3 interactions

CENPC CLASP1 APC CLASP2 ARHGEF2 ARHGAP21

7.46e-05230626int:MAPRE3
InteractionTRIM36 interactions

CLASP1 APC CLASP2 ARHGEF2 ARHGAP21

8.10e-05144625int:TRIM36
InteractionANKRD28 interactions

PLEKHG1 ANK2 KCNV2 IQSEC1 APC ARHGEF2

8.40e-05235626int:ANKRD28
InteractionGSK3A interactions

CLASP1 KIF26B APC CLASP2 SIPA1L2 ARHGAP21 SLX4 GOLGA3

8.45e-05464628int:GSK3A
InteractionDYNLT1 interactions

CLASP1 IQSEC1 CLASP2 ZNF318 ARHGEF2 ARHGAP21

9.65e-05241626int:DYNLT1
InteractionNIN interactions

PLEKHG1 CLASP1 APC CLASP2 ARHGEF2 SIPA1L2 ARHGAP21

1.14e-04359627int:NIN
InteractionSIRT6 interactions

ARHGAP22 SETD2 SETD1B HECTD4 APC NKTR ZNF318 ARHGEF2 SLX4

1.21e-04628629int:SIRT6
InteractionMAD2L1 interactions

HIVEP1 APC KDM3B ZNF318 REV3L SLX4

1.23e-04252626int:MAD2L1
InteractionYWHAQ interactions

ARHGEF28 CLASP1 KIF26B HECTD4 APC MAP3K9 MAP3K10 CLASP2 SAMSN1 ARHGEF2 SIPA1L2 ARHGAP21

1.31e-0411186212int:YWHAQ
InteractionSRGAP1 interactions

RAD18 NKTR ARHGEF2 ARHGAP21

1.85e-0492624int:SRGAP1
InteractionC6orf141 interactions

IQSEC1 ZNF318 SIPA1L2 OBI1

1.85e-0492624int:C6orf141
InteractionSPATA6L interactions

SPATA6L GOLGA3

1.94e-047622int:SPATA6L
InteractionTERF2IP interactions

UIMC1 SETD2 RAD18 HIVEP1 CENPC KDM3B ZNF318 SLX4

2.77e-04552628int:TERF2IP
Cytoband9p24.2

SPATA6L KCNV2

9.79e-05116229p24.2
GeneFamilyPDZ domain containing

LIMK2 FRMPD1 SIPA1L2 ARHGAP21 TJP3

2.60e-051524251220
GeneFamilyRho GTPase activating proteins|BCH domain containing

ARHGAP22 ARHGAP31 ARHGAP21

2.12e-0450423721
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PLEKHG1 ARHGAP22 ARHGEF2 ARHGAP21

1.31e-03206424682
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

MAP3K9 MAP3K10

1.41e-0324422654
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

SETD2 SETD1B

2.82e-0334422487
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

PKP3 APC

4.48e-0343422409
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PLEKHG1 ARHGEF2

1.03e-0266422722
GeneFamilyImmunoglobulin kappa locus at 2p11.2

IGKV2D-40 IGKV2-40

1.59e-0283422351
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

USP53 SPATA6L TENM3 PAX8 SAMSN1 TJP3

2.73e-071916263e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4/8-lo-Trm_Tgd|lymph-node_spleen / Manually curated celltypes from each tissue

USP53 LIMK2 DYNC2H1 PROCA1 ANKRD6

2.51e-06155625b0e456c4915076e1d38282e116a6eb3230ae80dc
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

TENM3 ARHGAP31 REV3L ANKRD6 RECK

5.80e-0618462567164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SPATA6L TENM3 PAX8 SAMSN1 TJP3

7.50e-0619462569bff17df4a760ccf081cf52ff04af02c14f448d
ToppCellILEUM-non-inflamed-(3)_MNP-(3)_moDC|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

NKTR SAMSN1 HPS5 PAPOLG

3.78e-05135624b7a792a7c0c22d8b703509f134115f0e394d7de0
ToppCellIonocyte-iono-3|World / Class top

TRPC4 PROCA1 ZNF318 ANKRD6

8.44e-051666249c4a780f8af46d7552077c7a0ae0ab1b2413e5d4
ToppCellnormal_Lung-B_lymphocytes-Undetermined|B_lymphocytes / Location, Cell class and cell subclass

ARHGAP22 ARHGEF28 PKP3 SAMSN1

9.46e-05171624f49dfe11ae66d82125b577c48345a13683d7bb7b
ToppCell390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

DYNC2H1 PKP3 SAMSN1 GOLGA3

9.90e-05173624b9dee61973559e8c2fef3f2dafd43475b386befb
ToppCell390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

DYNC2H1 PKP3 PHTF2 SAMSN1

1.06e-04176624437cfc5e06416bb0fc76d1f9dc106f74e279e880
ToppCellCOVID-19-kidney-Epi_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

ARHGEF28 TENM3 PAX8 KIF26B

1.10e-04178624544379f5a6145429762258d426b876bb36c112f5
ToppCellB_cells-Naive_B_cells_|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

PLEKHG1 HECTD4 IQSEC1 ZNF318

1.10e-0417862471ac2eca5cf13a91f86b80690748b0788392dcfc
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_TMEM233|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

USP53 ARHGEF28 TENM3 PROCA1

1.13e-04179624747a32460b257fffca30527b56a74720eb9c12e4
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 KIF26B TRPC4 FRMPD1

1.13e-04179624d1365d48d1b017a7917f4f63a82ac4720c3d87df
ToppCell15-Airway-Epithelial-Submucosal_gland|Airway / Age, Tissue, Lineage and Cell class

ARHGEF28 PKP3 OXGR1 TJP3

1.15e-04180624283bb0d58811947bfda4e286b9ec87d869c8e29e
ToppCelldroplet-Kidney-nan-21m-Mesenchymal-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP22 RAD18 SPATA6L ANK2

1.23e-04183624ad7421623e4c0c5ba02eec56e9bdae43ebb88d90
ToppCellcellseq-Immune-Immune_Myeloid-Myeloid_Dendritic-maDC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ARHGAP22 DCANP1 IGKV2D-40 SAMSN1

1.23e-04183624e01dacb08a9c36cf09c0b6764ce032a7232d4cdc
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 KIF26B TRPC4 FRMPD1

1.23e-0418362404d3cc76038b8192c915f1c08c3e26f2ad3b3779
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

PLEKHG1 ARHGEF28 ARHGAP31 SIPA1L2

1.34e-0418762440ffc06a3e3251d9b12da390210d3e045af7537a
ToppCellControl-Endothelial-Endothelial-Alv_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLEKHG1 ARHGAP31 SIPA1L2 ARHGAP21

1.34e-04187624ea9d34bcd3bd1f36745846309ede349773de501a
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 KIF26B TRPC4 FRMPD1

1.39e-0418962499a13b1b669b0cd36e3096632351d9ade25d1173
ToppCellcellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PLEKHG1 HIVEP1 ARHGAP31 PAPOLG

1.39e-04189624bccb3481ffed597c845fe860da658505316105b5
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 KIF26B TRPC4 FRMPD1

1.42e-041906243f22c118d552345f731d4d49f0bcb5765d93de3b
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 KIF26B TRPC4 FRMPD1

1.42e-04190624305fbef734c350cfbf786ca7ff6e07093aab56ea
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 KIF26B TRPC4 FRMPD1

1.42e-0419062439ab890104b4264c68a968f920f4ccd84f0bc681
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 KIF26B TRPC4 FRMPD1

1.42e-041906248c9c230a509afaeee50644153974a5642b01a2b8
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 KIF26B TRPC4 FRMPD1

1.42e-041906240acf1d5da68db449d8c9e70519a236ce825f9d11
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 KIF26B TRPC4 FRMPD1

1.42e-04190624e58e4b6fbeb4368f738adac67ec10879c0966f0f
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK2 TENM3 KIF26B REV3L

1.42e-0419062445df8fee00f8949937863159d7aa042e72748d9b
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L2-4_SST_AHR|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 KIF26B TRPC4 FRMPD1

1.45e-04191624782bc7946417549ffd39e5b596db659436fa01ba
ToppCellwk_15-18-Hematologic_Lymphocytic-T_&_ILC-ILC2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

GPR25 PHTF2 SAMSN1 BEGAIN

1.48e-04192624017f613b1b9c0bd0842e5c1e71d3ac60dd89eadd
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 KIF26B TRPC4 FRMPD1

1.48e-041926240003d7ef9a8e521e70ac33c63aad843d9b6215c2
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK2 TENM3 KIF26B REV3L

1.48e-04192624df1545670370fb1010c567cd059c2783eab315f7
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 KIF26B TRPC4 FRMPD1

1.51e-04193624c4b22b62f3cc7bf0ec0eba76e1504c236290bbc9
ToppCellFetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PLEKHG1 LIMK2 KIF26B SIPA1L2

1.51e-04193624ad2df9b77999780860141be6ec366afc0172a331
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SPATA6L TENM3 PAX8 TJP3

1.54e-0419462404bfc555743f7d8821439d05ae442d15e9886c59
ToppCellCOVID-19-Fibroblasts-Alveolar_FB|COVID-19 / group, cell type (main and fine annotations)

USP53 TENM3 KIF26B TRPC4

1.57e-04195624603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SPATA6L ARHGEF28 ANK2 PAX8

1.60e-04196624c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ANK2 TENM3 DYNC2H1 REV3L

1.63e-04197624fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCellTracheal-NucSeq-Stromal-Schwann|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ANK2 TENM3 ARHGAP31 SIPA1L2

1.63e-04197624c1b2a3fbd5f4aeb3555d8c372efc86f1052e7c65
ToppCellCOVID-19-lung-Fibroblast|lung / Disease (COVID-19 only), tissue and cell type

USP53 ANK2 TENM3 KIF26B

1.66e-04198624df3de77216f5c5d6141ec44d01c56b942f611838
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

ANK2 TENM3 DYNC2H1 BEGAIN

1.66e-041986240c4d2c68a42f8a9e964e2dd28092fe75f5216834
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ANK2 TENM3 DYNC2H1 REV3L

1.69e-04199624a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB|Neuronal / cells hierarchy compared to all cells using T-Statistic

TENM3 KIF26B TRPC4 FRMPD1

1.73e-04200624e79d93d55b25804f2608185168da472301b6ebca
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ANK2 DYNC2H1 KIF26B REV3L

1.73e-042006249b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCellBronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LIMK2 ARHGEF28 OXGR1 HPS5

1.73e-04200624030efc36bbb848da31b0db3f74d46aac9c79cc9b
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Neuron|10w / Sample Type, Dataset, Time_group, and Cell type.

SETD1B ARHGEF2 OBI1 ARHGAP21

1.73e-04200624332905a686356cd1e024d40679be98e9d8b1b5e8
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

USP53 ANK2 TENM3 TRPC4

1.73e-04200624311fab076f2ceb258e3970eb21e39344b894042a
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB--L2-4|Neuronal / cells hierarchy compared to all cells using T-Statistic

TENM3 KIF26B TRPC4 FRMPD1

1.73e-042006245ec469267747dce3601c1d8ad01af89fa5b29acc
ToppCellmLN-Dendritic_cell-Lymphoid_DC|Dendritic_cell / Region, Cell class and subclass

ARHGAP22 SETD2 SETD1B SAMSN1

1.73e-042006243813fa1ee1462ba83fd8b6253070f46f0b063084
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB-|Neuronal / cells hierarchy compared to all cells using T-Statistic

TENM3 KIF26B TRPC4 FRMPD1

1.73e-04200624320d5a3a1e7da2fa8f1a164e29e180ec8ac9889c
Drug17-DMAG; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

LIMK2 HIVEP1 NKTR ZNF318 ANKRD6 TJP3

9.35e-06192586993_DN
DrugTiapride hydrochloride [51012-33-0]; Up 200; 11uM; HL60; HT_HG-U133A

SETD2 TRPC4 FRMPD1 NKTR TEX15 TJP3

1.05e-051965862331_UP
DrugAlverine citrate salt [5560-59-8]; Up 200; 8.4uM; PC3; HT_HG-U133A

SETD2 ARHGEF28 PKP3 APC CLASP2 NKTR

1.08e-051975862110_UP
DrugPargyline hydrochloride [306-07-0]; Down 200; 20.4uM; MCF7; HT_HG-U133A

LIMK2 NSMF DYNC2H1 PKP3 APC ANKRD6

1.11e-051985867016_DN
DrugBufexamac [2438-72-4]; Down 200; 18uM; MCF7; HT_HG-U133A

PKP3 APC NKTR ZNF318 TJP3 PAPOLG

1.11e-051985865515_DN
Drugsulindac sulfone; Down 200; 50uM; MCF7; HG-U133A

ANK2 PAX8 MAP3K9 TEX15 ARHGEF2 BEGAIN

1.15e-05199586309_DN
DrugIvermectin [70288-86-7]; Up 200; 4.6uM; MCF7; HT_HG-U133A

FRMPD1 MAP3K9 PHTF2 NKTR ARHGEF2

1.20e-041895857206_UP
DrugMeticrane [1084-65-7]; Up 200; 14.6uM; PC3; HT_HG-U133A

ARHGAP22 SETD2 ARHGEF28 SETD1B NKTR

1.29e-041925851792_UP
DrugPindolol [13523-86-9]; Down 200; 16.2uM; MCF7; HT_HG-U133A

TENM3 APC MAP3K9 ZNF318 TJP3

1.36e-041945852238_DN
DrugRapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A

LIMK2 APC CLASP2 NKTR GOLGA3

1.39e-041955856927_DN
DrugFillalbin [4540-25-4]; Up 200; 13.8uM; MCF7; HT_HG-U133A

FRMPD1 APC TBC1D22B NKTR ARHGEF2

1.39e-041955854172_UP
DrugTranylcypromine hydrochloride [1986-47-6]; Up 200; 23.6uM; PC3; HT_HG-U133A

ARHGAP22 SETD2 PAX8 APC NKTR

1.42e-041965852101_UP
DrugIoversol [87771-40-2]; Down 200; 5uM; MCF7; HT_HG-U133A

LIMK2 PKP3 NKTR ARHGEF2 TJP3

1.42e-041965855326_DN
DrugGabazine [105538-73-6]; Down 200; 10.8uM; PC3; HT_HG-U133A

PKP3 FRMPD1 APC TBC1D22B TJP3

1.42e-041965854236_DN
DrugMetyrapone [54-36-4]; Down 200; 17.6uM; HL60; HT_HG-U133A

LIMK2 IQSEC1 APC PHTF2 NKTR

1.46e-041975853070_DN
DrugBromocryptine mesylate [22260-51-1]; Down 200; 5.4uM; PC3; HT_HG-U133A

LIMK2 ARHGEF28 MAP3K9 NKTR ZNF318

1.46e-041975854604_DN
DrugIdazoxan hydrochloride [79944-56-2]; Down 200; 16.6uM; PC3; HT_HG-U133A

PKP3 PHTF2 TBC1D22B NKTR TJP3

1.46e-041975856747_DN
DrugMeropenem [96036-03-2]; Up 200; 10.4uM; MCF7; HT_HG-U133A

PKP3 APC CLASP2 NKTR TJP3

1.46e-041975857180_UP
DrugAG-013608 [351320-38-2]; Up 200; 10uM; PC3; HT_HG-U133A

GPR25 PAX8 APC ARHGEF2 TJP3

1.46e-041975856400_UP
DrugCatechin-(+,-) hydrate [7295-85-4]; Up 200; 13.8uM; MCF7; HT_HG-U133A

LIMK2 ARHGEF28 KCNV2 TEX15 ARHGEF2

1.46e-041975853351_UP
DrugMetolazone [17560-51-9]; Up 200; 11uM; MCF7; HT_HG-U133A

PAX8 TRPC4 IQSEC1 APC SAMSN1

1.46e-041975851514_UP
DrugNorfloxacin [70458-96-7]; Up 200; 12.6uM; PC3; HT_HG-U133A

PAX8 PKP3 FRMPD1 APC TJP3

1.46e-041975857283_UP
DrugMafenide hydrochloride [138-37-4]; Up 200; 18uM; PC3; HT_HG-U133A

SETD2 SETD1B SAMSN1 RECK PAPOLG

1.49e-041985852124_UP
DrugMebendazole [31431-39-7]; Down 200; 13.6uM; MCF7; HT_HG-U133A

TENM3 DYNC2H1 APC CLASP2 NKTR

1.49e-041985854694_DN
Drug2-propylpentanoic acid; Up 200; 50uM; MCF7; HT_HG-U133A_EA

SETD2 PKP3 PHTF2 NKTR ANKRD6

1.49e-041985851002_UP
DrugNaftifine hydrochloride [65473-14-5]; Down 200; 12.4uM; MCF7; HT_HG-U133A

SETD2 DYNC2H1 IQSEC1 APC TJP3

1.49e-041985857032_DN
DrugTrazodone hydrochloride [25332-39-2]; Down 200; 9.8uM; MCF7; HT_HG-U133A

SETD2 LIMK2 DYNC2H1 CLASP2 NKTR

1.53e-041995857452_DN
DrugTheophylline monohydrate [5967-84-0]; Down 200; 20.2uM; PC3; HT_HG-U133A

FRMPD1 APC PHTF2 TEX15 TJP3

1.53e-041995854228_DN
DrugParomomycin sulfate [1263-89-4]; Down 200; 5.6uM; HL60; HT_HG-U133A

ANK2 PAX8 PHTF2 TEX15 ANKRD6

1.53e-041995853017_DN
DrugNicergoline; Down 200; 8.2uM; MCF7; HT_HG-U133A

LIMK2 PKP3 APC MAP3K9 ARHGEF2

1.53e-041995852220_DN
DrugOxamniquine [21738-42-1]; Up 200; 14.4uM; PC3; HT_HG-U133A

APC PHTF2 TBC1D22B TEX15 BEGAIN

1.56e-042005854006_UP
DiseaseShort Stature, CTCAE

IQSEC1 KDM3B

1.75e-0410592C2919142
DiseaseShort stature

IQSEC1 KDM3B

1.75e-0410592C0349588
Diseasealcohol and nicotine codependence

PLEKHG1 HIVEP1

3.02e-0413592EFO_0004776
Diseasereceptive language perception, parental genotype effect measurement

PLEKHG1 MUC19

3.52e-0414592EFO_0005686, EFO_0005939
Diseasegamma-glutamylphenylalanine measurement

SAMSN1 ARHGEF2

4.06e-0415592EFO_0021142
DiseaseAbnormal behavior

IQSEC1 KDM3B

4.63e-0416592C0233514
DiseaseAlpha ketoglutarate measurement

TENM3 KCNV2

4.63e-0416592EFO_0010457
Diseaseresponse to radiation

WDR64 HIVEP1 KDM3B

7.38e-0488593GO_0009314
Diseaseskin hydration measurement

PLEKHG1 ARHGAP21

8.05e-0421592EFO_0009586
Diseaserenal system measurement, blood urea nitrogen measurement

PAX8 HECTD4

8.85e-0422592EFO_0004741, EFO_0004742
DiseaseDwarfism

IQSEC1 KDM3B

1.14e-0325592C0013336
Diseasegamma-glutamyltyrosine measurement

ARHGEF2 ARHGAP21

1.34e-0327592EFO_0021144
DiseaseC-X-C motif chemokine 10 measurement

ARHGEF28 TENM3 HECTD4

1.37e-03109593EFO_0008056
Diseaselumbar disc degeneration

HIVEP1 DYNC2H1

1.44e-0328592EFO_0004994
Diseasediastolic blood pressure, unipolar depression

PLEKHG1 HECTD4

1.65e-0330592EFO_0003761, EFO_0006336
Diseasesystolic blood pressure, alcohol drinking

PLEKHG1 HECTD4 ZNF318

2.17e-03128593EFO_0004329, EFO_0006335

Protein segments in the cluster

PeptideGeneStartEntry
SLTCSDSQSRRVSSS

DCANP1

211

Q8TF63
SSRLSDASARDLAFC

BEGAIN

196

Q9BUH8
SIELCRADSDSSQRD

ARHGEF2

711

Q92974
ASSLSRDDSSVFRCR

GPR25

336

O00155
ADSVRSSNLSLCCSD

BTBD11

26

A6QL63
QELSSSDCTGSRLRN

ANKRD6

576

Q9Y2G4
SDQDSCRLSIDSQSS

PAX8

201

Q06710
SDSCNSSSSDIIRDL

RAD18

436

Q9NS91
STRLCLSEHSSEDDR

RECK

611

O95980
LACDSRRVSFSQSSS

IQCM

206

A0A1B0GVH7
NSCRSRSHSDELLQS

ARHGEF28

781

Q8N1W1
CTRDESSVQSSRSER

ANK2

1571

Q01484
ISCRSSQSLLDSDDG

IGKV2D-40

41

P01614
SVSDCNSTRSLLRSD

MAP3K10

751

Q02779
SRDISRSESLRCSSS

LIMK2

306

P53671
DTINCSSESSSRDSL

IQSEC1

481

Q6DN90
RICSTLARDTSESSS

KIF26B

456

Q2KJY2
SSRRGSQSDEDSCSL

HPS5

456

Q9UPZ3
NSSCRSLSERDRSCD

MUC19

1091

Q7Z5P9
ASIDSSASSSLRCLS

MYF6

206

P23409
SASSSLRCLSSIVDS

MYF6

211

P23409
SSSRLCDTSSARQES

OBI1

316

Q5W0B1
ERSLACRQDSDSSTN

KDM3B

801

Q7LBC6
RDSSDLQSSHCTLDE

NSMF

306

Q6X4W1
DRLCSLSNQTESSSS

HECTD4

1296

Q9Y4D8
RRDSICSSVSLESSA

GOLGA3

386

Q08378
NRTNRSACLDLTSSD

OXGR1

176

Q96P68
SKRLSLDSSCLDSSR

PAPOLG

521

Q9BWT3
LSDSRSGLCIEASSR

DYNC2H1

546

Q8NCM8
LDCSRSTRSSKNEDN

CENPC

631

Q03188
ALEEDDLDTCSSSRS

FRMPD1

611

Q5SYB0
ISCRSSQSLLDSDDG

IGKV2-40

41

A0A087WW87
CNSRLKDSSEDSSSS

PROCA1

101

Q8NCQ7
SECNSTRSLLRSDSD

MAP3K9

841

P80192
CSSSRQDSESARPES

PHTF2

386

Q8N3S3
ERIVLRSDSSSCLDS

SPATA6L

276

Q8N4H0
SSDAQLSRNSSDTCL

TBC1D22B

131

Q9NU19
KSSCDRERSSRSSSL

NKTR

476

P30414
RSDSGSDLLRCTERT

SPATA31A6

706

Q5VVP1
SCSDGTSNRDSFRLD

SAMSN1

141

Q9NSI8
LATSTSRSRQLSLCD

KCNV2

126

Q8TDN2
TLSDESICSNRRGSS

SIPA1L2

1486

Q9P2F8
QRRLLSSFTGSCDSD

SETD1B

1801

Q9UPS6
LSSCTACRASDSSAR

ARHGAP22

526

Q7Z5H3
SRDCSSQTQISSLRS

SLX4

1266

Q8IY92
RCTSVSSLDSFESRS

APC

1386

P25054
AACLSRQASSDSDSI

APC

2121

P25054
GCSRDTSRESSRDTS

CLASP1

751

Q7Z460
QGCSREASRESSRDT

CLASP2

526

O75122
SRDRGNSCDSSSKSR

USP53

566

Q70EK8
SRSAVDLSCSRRLSS

PKP3

121

Q9Y446
SLCRNTHRSSTEDDD

REV3L

486

O60673
ESSRDCALSSTLEDT

ZNF274

356

Q96GC6
CLSSRSNSALTLTDT

TENM3

146

Q9P273
SSSSCANLETERNSD

ARHGAP31

971

Q2M1Z3
RDLRTSSYSKSDRDC

SETD2

481

Q9BYW2
ADSSADLSCDSRVNS

TJP3

791

O95049
FSSSDLNSTRLCEDS

PLEKHG1

566

Q9ULL1
LNSTRLCEDSTSSRP

PLEKHG1

571

Q9ULL1
RLTSQDSSECFSSLS

TEX15

946

Q9BXT5
CTEGSLTSSLDSRRQ

ARHGAP21

1676

Q5T5U3
LTDDSVFTRSSQCSR

ZNF318

186

Q5VUA4
ESLNSCRPSDASATR

UIMC1

116

Q96RL1
EQCDSSSLSSKTRTD

HIVEP1

161

P15822
CVSSSDVDSLRHSRS

TRPC4

181

Q9UBN4
CARRSSQDSICSSSQ

WDR64

716

B1ANS9