Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	steroid 11-beta-monooxygenase activity	CYP11B1 CYP11B2	1.28e-05	2	72	2	GO:0004507
GeneOntologyMolecularFunction	corticosterone 18-monooxygenase activity	CYP11B1 CYP11B2	1.28e-05	2	72	2	GO:0047783
GeneOntologyMolecularFunction	pyruvate dehydrogenase (acetyl-transferring) kinase activity	PDK1 PDK4	1.27e-04	5	72	2	GO:0004740
GeneOntologyBiologicalProcess	regulation of sulfur metabolic process	TM9SF2 PDK1 PDK4	2.57e-05	17	71	3	GO:0042762
GeneOntologyBiologicalProcess	amide metabolic process	TM9SF2 MGST1 DGAT2 PDK1 PDK4 PLA2G6 SMPD1 RENBP CARNS1	6.24e-05	511	71	9	GO:0043603
GeneOntologyBiologicalProcess	regulation of blood volume by renal aldosterone	CYP11B1 CYP11B2	6.98e-05	4	71	2	GO:0002017
GeneOntologyBiologicalProcess	regulation of acetyl-CoA biosynthetic process from pyruvate	PDK1 PDK4	6.98e-05	4	71	2	GO:0010510
GeneOntologyBiologicalProcess	regulation of acyl-CoA biosynthetic process	PDK1 PDK4	1.16e-04	5	71	2	GO:0050812
GeneOntologyCellularComponent	Mon1-Ccz1 complex	CCZ1B CCZ1	1.16e-04	5	72	2	GO:0035658
MousePheno	abnormal adrenal gland zona fasciculata size	CYP11B1 CYP11B2 PDPK2P	9.82e-06	11	56	3	MP:0014284
MousePheno	abnormal urine progesterone level	CYP11B1 CYP11B2	1.58e-05	2	56	2	MP:0011545
MousePheno	abnormal urine deoxycorticosterone level	CYP11B1 CYP11B2	1.58e-05	2	56	2	MP:0011552
MousePheno	decreased urine corticosterone level	CYP11B1 CYP11B2	1.58e-05	2	56	2	MP:0011550
MousePheno	increased urine deoxycorticosterone level	CYP11B1 CYP11B2	1.58e-05	2	56	2	MP:0011553
MousePheno	increased urine progesterone level	CYP11B1 CYP11B2	1.58e-05	2	56	2	MP:0011546
MousePheno	abnormal adrenal gland zona fasciculata morphology	CYP11B1 CYP11B2 PDPK2P	5.64e-05	19	56	3	MP:0008294
MousePheno	abnormal adrenal gland zona glomerulosa morphology	CYP11B1 CYP11B2	9.41e-05	4	56	2	MP:0008293
MousePheno	decreased urine aldosterone level	CYP11B1 CYP11B2	9.41e-05	4	56	2	MP:0011541
MousePheno	abnormal urine aldosterone level	CYP11B1 CYP11B2	9.41e-05	4	56	2	MP:0011539
MousePheno	abnormal urine corticosterone level	CYP11B1 CYP11B2	9.41e-05	4	56	2	MP:0011548
MousePheno	decreased urine hormone level	CYP11B1 CYP11B2	9.41e-05	4	56	2	MP:0014459
MousePheno	increased adrenal gland zona fasciculata size	CYP11B1 CYP11B2	1.56e-04	5	56	2	MP:0014286
MousePheno	uterus adenomyosis	CYP11B1 CYP11B2	2.34e-04	6	56	2	MP:0009221
MousePheno	increased urine hormone level	CYP11B1 CYP11B2	2.34e-04	6	56	2	MP:0014458
MousePheno	adrenal gland hyperplasia	CYP11B1 CYP11B2	2.34e-04	6	56	2	MP:0009078
MousePheno	abnormal urine hormone level	CYP11B1 CYP11B2	3.27e-04	7	56	2	MP:0011538
MousePheno	pituitary gland hyperplasia	CYP11B1 CYP11B2	3.27e-04	7	56	2	MP:0000635
MousePheno	increased circulating angiotensin II level	CYP11B1 CYP11B2	4.35e-04	8	56	2	MP:0031232
MousePheno	increased angiotensin II level	CYP11B1 CYP11B2	4.35e-04	8	56	2	MP:0031229
MousePheno	abnormal adrenal cortex morphology	CYP11B1 CYP11B2 PDPK2P	6.26e-04	42	56	3	MP:0008288
MousePheno	decreased circulating renin level	CYP11B1 CYP11B2	6.95e-04	10	56	2	MP:0003353
MousePheno	abnormal adrenocortical cell morphology	CYP11B1 CYP11B2	6.95e-04	10	56	2	MP:0008291
Domain	DUF1712	CCZ1B CCZ1	1.31e-05	2	68	2	PF08217
Domain	DUF1712_fun	CCZ1B CCZ1	1.31e-05	2	68	2	IPR013176
Domain	Cyt_P450_mitochondrial	CYP11B1 CYP11B2	1.31e-05	2	68	2	IPR002399
Domain	BCDHK_Adom3	PDK1 PDK4	1.30e-04	5	68	2	PF10436
Domain	His_kinase_dom	PDK1 PDK4	1.30e-04	5	68	2	IPR005467
Domain	HIS_KIN	PDK1 PDK4	1.30e-04	5	68	2	PS50109
Domain	-	PDK1 PDK4	1.30e-04	5	68	2	1.20.140.20
Domain	BCDHK/PDK_N	PDK1 PDK4	1.30e-04	5	68	2	IPR018955
Domain	VWFA	INTS6 CPNE6 VWA3B ITGAL	2.27e-04	82	68	4	PS50234
Domain	VWA	INTS6 CPNE6 VWA3B ITGAL	2.49e-04	84	68	4	SM00327
Domain	VWF_A	INTS6 CPNE6 VWA3B ITGAL	4.66e-04	99	68	4	IPR002035
Domain	Cyt_P450_CS	CYP11B1 CYP11B2 CYP2W1	9.49e-04	53	68	3	IPR017972
Domain	VWA	INTS6 VWA3B ITGAL	1.11e-03	56	68	3	PF00092
Domain	EamA_dom	SLC35G2 SLC35G6	1.16e-03	14	68	2	IPR000620
Domain	EamA	SLC35G2 SLC35G6	1.16e-03	14	68	2	PF00892
Domain	CYTOCHROME_P450	CYP11B1 CYP11B2 CYP2W1	1.17e-03	57	68	3	PS00086
Domain	-	CYP11B1 CYP11B2 CYP2W1	1.23e-03	58	68	3	1.10.630.10
Domain	p450	CYP11B1 CYP11B2 CYP2W1	1.23e-03	58	68	3	PF00067
Domain	Cyt_P450	CYP11B1 CYP11B2 CYP2W1	1.36e-03	60	68	3	IPR001128
Domain	HATPase_c	PDK1 PDK4	1.92e-03	18	68	2	SM00387
Domain	HATPase_c	PDK1 PDK4	2.15e-03	19	68	2	PF02518
Domain	-	PDK1 PDK4	2.38e-03	20	68	2	3.30.565.10
Domain	-	INTS6 CPNE6 VWA3B	2.49e-03	74	68	3	3.40.50.410
Domain	HATPase_C	PDK1 PDK4	2.62e-03	21	68	2	IPR003594
Domain	SPRY	TRIM16 RNF123 RNF39	3.93e-03	87	68	3	SM00449
Domain	Calcineurin-like_PHP_ApaH	SMPD1 PPP1CB	4.64e-03	28	68	2	IPR004843
Domain	Metallophos	SMPD1 PPP1CB	4.64e-03	28	68	2	PF00149
Domain	SPRY	TRIM16 RNF123 RNF39	4.88e-03	94	68	3	PF00622
Domain	SPRY_dom	TRIM16 RNF123 RNF39	4.88e-03	94	68	3	IPR003877
Domain	B30.2/SPRY	TRIM16 RNF123 RNF39	5.03e-03	95	68	3	IPR001870
Domain	B302_SPRY	TRIM16 RNF123 RNF39	5.03e-03	95	68	3	PS50188
Domain	Metallo-depent_PP-like	SMPD1 PPP1CB	5.32e-03	30	68	2	IPR029052
Domain	-	SMPD1 PPP1CB	5.32e-03	30	68	2	3.60.21.10
Pubmed	Genetic variants in the renin-angiotensin-aldosterone system and salt sensitivity of blood pressure.	CYP11B1 CYP11B2 RENBP	1.39e-06	11	72	3	20486282
Pubmed	Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.	CYP11B1 CYP11B2	4.23e-06	2	72	2	17651452
Pubmed	Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.	CYP11B1 CYP11B2	4.23e-06	2	72	2	23150505
Pubmed	Expression of CYP11B1 and CYP11B2 in adrenal adenoma correlates with clinical characteristics of primary aldosteronism.	CYP11B1 CYP11B2	4.23e-06	2	72	2	34743356
Pubmed	GRAde: a long-read sequencing approach to efficiently identifying the CYP11B1/CYP11B2 chimeric form in patients with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	4.23e-06	2	72	2	35012455
Pubmed	Role of genetic variation in regulation of aldosterone biosynthesis.	CYP11B1 CYP11B2	4.23e-06	2	72	2	21164264
Pubmed	Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism.	CYP11B1 CYP11B2	4.23e-06	2	72	2	20339375
Pubmed	Genetic analyses of the chimeric CYP11B1/CYP11B2 gene in a Korean family with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	4.23e-06	2	72	2	20808686
Pubmed	The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity.	CYP11B1 CYP11B2	4.23e-06	2	72	2	8645611
Pubmed	Expression and localization of cytochrome P450(11beta,aldo) mRNA in the frog brain.	CYP11B1 CYP11B2	4.23e-06	2	72	2	12231255
Pubmed	A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type I.	CYP11B1 CYP11B2	4.23e-06	2	72	2	20634641
Pubmed	Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.	CYP11B1 CYP11B2	4.23e-06	2	72	2	1303253
Pubmed	Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets.	CYP11B1 CYP11B2	4.23e-06	2	72	2	21519965
Pubmed	Diagnosis of glucocorticoid-remediable aldosteronism in hypertensive children.	CYP11B1 CYP11B2	4.23e-06	2	72	2	21625068
Pubmed	Genetic screening for glucocorticoid-remediable aldosteronism (GRA): experience of three clinical centres in Poland.	CYP11B1 CYP11B2	4.23e-06	2	72	2	16110193
Pubmed	Chimeric CYP11B2/CYP11B1 causing 11β-hydroxylase deficiency in Chinese patients with congenital adrenal hyperplasia.	CYP11B1 CYP11B2	4.23e-06	2	72	2	26066897
Pubmed	Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.	CYP11B1 CYP11B2	4.23e-06	2	72	2	1741400
Pubmed	Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice.	CYP11B1 CYP11B2	4.23e-06	2	72	2	32540969
Pubmed	Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice.	CYP11B1 CYP11B2	4.23e-06	2	72	2	26047574
Pubmed	Aldosterone synthase knockout mouse as a model for sodium-induced endothelial sodium channel up-regulation in vascular endothelium.	CYP11B1 CYP11B2	4.23e-06	2	72	2	26324851
Pubmed	Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules.	CYP11B1 CYP11B2	4.23e-06	2	72	2	18651133
Pubmed	Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains.	CYP11B1 CYP11B2	4.23e-06	2	72	2	7669222
Pubmed	A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation pattern.	CYP11B1 CYP11B2	4.23e-06	2	72	2	22083159
Pubmed	Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron.	CYP11B1 CYP11B2	4.23e-06	2	72	2	22933298
Pubmed	Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	4.23e-06	2	72	2	2783417
Pubmed	Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.	CYP11B1 CYP11B2	4.23e-06	2	72	2	2256920
Pubmed	Editorial: polymorphisms in CYP11B genes and 11-hydroxylase activity.	CYP11B1 CYP11B2	4.23e-06	2	72	2	15699546
Pubmed	Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway.	CYP11B1 CYP11B2	4.23e-06	2	72	2	18162527
Pubmed	Chronic activation of adrenal Gq signaling induces Cyp11b2 expression in the zona fasciculata and hyperaldosteronism.	CYP11B1 CYP11B2	4.23e-06	2	72	2	38341019
Pubmed	Association of DNA polymorphisms within the CYP11B2/CYP11B1 locus and postoperative hypertension risk in the patients with aldosterone-producing adenomas.	CYP11B1 CYP11B2	4.23e-06	2	72	2	20708777
Pubmed	Molecular genetic studies on the biosynthesis of aldosterone in humans.	CYP11B1 CYP11B2	4.23e-06	2	72	2	22217843
Pubmed	Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation.	CYP11B1 CYP11B2	4.23e-06	2	72	2	16396990
Pubmed	Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.	CYP11B1 CYP11B2	4.23e-06	2	72	2	24837548
Pubmed	Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity.	CYP11B1 CYP11B2	4.23e-06	2	72	2	30046010
Pubmed	Familial and phenotypic associations of the aldosterone Renin ratio.	CYP11B1 CYP11B2	4.23e-06	2	72	2	19820005
Pubmed	[123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes.	CYP11B1 CYP11B2	4.23e-06	2	72	2	18397978
Pubmed	Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.	CYP11B1 CYP11B2	4.23e-06	2	72	2	1518866
Pubmed	Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.	CYP11B1 CYP11B2	4.23e-06	2	72	2	22622494
Pubmed	Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production.	CYP11B1 CYP11B2	4.23e-06	2	72	2	15062555
Pubmed	Procollagen I-expressing renin cell precursors.	CYP11B1 CYP11B2	4.23e-06	2	72	2	23761669
Pubmed	Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption.	CYP11B1 CYP11B2	4.23e-06	2	72	2	17075030
Pubmed	Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency.	CYP11B1 CYP11B2	4.23e-06	2	72	2	17075029
Pubmed	Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).	CYP11B1 CYP11B2	4.23e-06	2	72	2	2592361
Pubmed	CYP11B2-CYP11B1 haplotypes associated with decreased 11 beta-hydroxylase activity.	CYP11B1 CYP11B2	4.23e-06	2	72	2	15507509
Pubmed	Polymorphism of CYP11B2 determines salt sensitivity in Japanese.	CYP11B1 CYP11B2	4.23e-06	2	72	2	17296872
Pubmed	Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice.	CYP11B1 CYP11B2	4.23e-06	2	72	2	23314847
Pubmed	Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects.	CYP11B1 CYP11B2	4.23e-06	2	72	2	17980006
Pubmed	Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene.	CYP11B1 CYP11B2	4.23e-06	2	72	2	16984984
Pubmed	Evidence for local aldosterone synthesis in the large intestine of the mouse.	CYP11B1 CYP11B2	4.23e-06	2	72	2	35288482
Pubmed	Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice.	CYP11B1 CYP11B2	4.23e-06	2	72	2	15731365
Pubmed	Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase.	CYP11B1 CYP11B2	4.23e-06	2	72	2	18039983
Pubmed	Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.	CYP11B1 CYP11B2	4.23e-06	2	72	2	19029289
Pubmed	Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.	CYP11B1 CYP11B2	4.23e-06	2	72	2	15522937
Pubmed	Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids.	CYP11B1 CYP11B2	1.27e-05	3	72	2	36861295
Pubmed	PDK1 is important lipid kinase for RANKL-induced osteoclast formation and function via the regulation of the Akt-GSK3β-NFATc1 signaling cascade.	PDK1 PDPK2P	1.27e-05	3	72	2	32048762
Pubmed	Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior.	CYP11B1 CYP11B2	1.27e-05	3	72	2	36778748
Pubmed	Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain.	CYP11B1 CYP11B2	1.27e-05	3	72	2	8111631
Pubmed	The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells.	CYP11B1 CYP11B2	1.27e-05	3	72	2	2546938
Pubmed	Kidney function in mice lacking aldosterone.	CYP11B1 CYP11B2	1.27e-05	3	72	2	16118390
Pubmed	Interaction of CYP11B1 (cytochrome P-45011 beta) with CYP11A1 (cytochrome P-450scc) in COS-1 cells.	CYP11B1 CYP11B2	1.27e-05	3	72	2	10411633
Pubmed	Differential effects of high and low steroidogenic factor-1 expression on CYP11B2 expression and aldosterone production in adrenocortical cells.	CYP11B1 CYP11B2	1.27e-05	3	72	2	18974272
Pubmed	PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.	CCZ1B CCZ1	1.27e-05	3	72	2	32160108
Pubmed	Aldosterone-induced coronary dysfunction in transgenic mice involves the calcium-activated potassium (BKCa) channels of vascular smooth muscle cells.	CYP11B1 CYP11B2	1.27e-05	3	72	2	17984374
Pubmed	Different isozymes of mouse 11 beta-hydroxylase produce mineralocorticoids and glucocorticoids.	CYP11B1 CYP11B2	1.27e-05	3	72	2	1686470
Pubmed	Identification and characterization of two upstream elements that regulate adrenocortical expression of steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	1.27e-05	3	72	2	2233742
Pubmed	Metabolic remodeling of cardiomyocytes identified in phosphoinositide-dependent kinase 1-deficient mice.	PDK1 PDPK2P	1.27e-05	3	72	2	31208986
Pubmed	Substrate-induced modulation of protein-protein interactions within human mitochondrial cytochrome P450-dependent system.	CYP11B1 CYP11B2	1.27e-05	3	72	2	33271253
Pubmed	Mislocalization of protein kinase A drives pathology in Cushing's syndrome.	CYP11B1 CYP11B2	1.27e-05	3	72	2	35830806
Pubmed	The prolactin regulatory element-binding regulates of the 11beta-hydroxylase gene.	CYP11B1 CYP11B2	1.27e-05	3	72	2	18801336
Pubmed	Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1.	CYP11B1 CYP11B2	1.27e-05	3	72	2	11932209
Pubmed	PDK1 Regulates the Lengthening of G1 Phase to Balance RGC Proliferation and Differentiation during Cortical Neurogenesis.	PDK1 PDPK2P	1.27e-05	3	72	2	34918060
Pubmed	Pivotal role of PDK1 in megakaryocyte cytoskeletal dynamics and polarization during platelet biogenesis.	PDK1 PDPK2P	1.27e-05	3	72	2	31578203
Pubmed	Aldosterone postnatally, but not at birth, is required for optimal induction of renal mineralocorticoid receptor expression and sodium reabsorption.	CYP11B1 CYP11B2	1.27e-05	3	72	2	21467193
Pubmed	PDK1 is a negative regulator of axon regeneration.	PDK1 PDPK2P	1.27e-05	3	72	2	33579325
Pubmed	Control of renin secretion from kidneys with renin cell hyperplasia.	CYP11B1 CYP11B2	1.27e-05	3	72	2	24285498
Pubmed	Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis.	CYP11B1 CYP11B2	1.27e-05	3	72	2	7750493
Pubmed	Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis.	CYP11B1 CYP11B2	1.27e-05	3	72	2	26471128
Pubmed	Molecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis.	CYP11B1 CYP11B2	1.27e-05	3	72	2	28355486
Pubmed	Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting.	PDK1 PDK4	1.27e-05	3	72	2	14966024
Pubmed	Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes.	CYP11B1 CYP11B2	1.27e-05	3	72	2	32245948
Pubmed	Hepatic Glucocorticoid Receptor Plays a Greater Role Than Adipose GR in Metabolic Syndrome Despite Renal Compensation.	LIPE DGAT2 PPP1CB	1.67e-05	24	72	3	27754788
Pubmed	Zona Glomerulosa-Derived Klotho Modulates Aldosterone Synthase Expression in Young Female Mice.	CYP11B1 CYP11B2	2.53e-05	4	72	2	38573585
Pubmed	Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis.	CYP11B1 CYP11B2	2.53e-05	4	72	2	38301271
Pubmed	Crosstalk between androgen receptor and WNT/β-catenin signaling causes sex-specific adrenocortical hyperplasia in mice.	CYP11B1 CYP11B2	2.53e-05	4	72	2	37102205
Pubmed	Familial varieties of primary aldosteronism.	CYP11B1 CYP11B2	2.53e-05	4	72	2	11903322
Pubmed	Deficiency of Pdk1 drives heart failure by impairing taurine homeostasis through Slc6a6.	PDK1 PDPK2P	2.53e-05	4	72	2	37561545
Pubmed	Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complex.	PDK1 PDK4	2.53e-05	4	72	2	30482839
Pubmed	Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor.	CYP11B1 CYP11B2	2.53e-05	4	72	2	19342457
Pubmed	Cutting Edge: De Novo Glucocorticoid Synthesis by Thymic Epithelial Cells Regulates Antigen-Specific Thymocyte Selection.	CYP11B1 CYP11B2	2.53e-05	4	72	2	29440508
Pubmed	The aldo-keto reductase AKR1B7 coexpresses with renin without influencing renin production and secretion.	CYP11B1 CYP11B2	2.53e-05	4	72	2	23303406
Pubmed	Deletion of PDK1 in oligodendrocyte lineage cells causes white matter abnormality and myelination defect in the central nervous system.	PDK1 PDPK2P	2.53e-05	4	72	2	33276084
Pubmed	Central insulin action induces activation of paraventricular oxytocin neurons to release oxytocin into circulation.	PDK1 PDPK2P	2.53e-05	4	72	2	29991705
Pubmed	Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation.	PDK1 PDK4	2.53e-05	4	72	2	25991547
Pubmed	Single-Cell Resolution and Quantitation of Targeted Glucocorticoid Delivery in the Thymus.	CYP11B1 CYP11B2	2.53e-05	4	72	2	30917317
Pubmed	Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation.	CYP11B1 CYP11B2	2.53e-05	4	72	2	32320669
Pubmed	Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases.	LIPE DGAT2	2.53e-05	4	72	2	23066022
Pubmed	β-Catenin-Driven Differentiation Is a Tissue-Specific Epigenetic Vulnerability in Adrenal Cancer.	CYP11B1 CYP11B2	2.53e-05	4	72	2	37129912
Pubmed	Twin genes and endocrine disease: CYP21 and CYP11B genes.	CYP11B1 CYP11B2	2.53e-05	4	72	2	8372604
Pubmed	Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells.	CCZ1B CCZ1	2.53e-05	4	72	2	20305638
Pubmed	Formation of functional heterodimers by isozymes 1 and 2 of pyruvate dehydrogenase kinase.	PDK1 PDK4	2.53e-05	4	72	2	12573248
Cytoband	7p22.1	CCZ1B TNRC18 CCZ1	5.71e-05	47	72	3	7p22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr7p22	CCZ1B TNRC18 CCZ1 CYP2W1	6.12e-05	134	72	4	chr7p22
Cytoband	3p22.3	CMTM6 CRTAP	1.10e-03	31	72	2	3p22.3
Cytoband	Ensembl 112 genes in cytogenetic band chr2p23	CLIP4 GALNT14 PPP1CB	1.70e-03	149	72	3	chr2p23
GeneFamily	Cytochrome P450 family 11	CYP11B1 CYP11B2	2.15e-05	3	49	2	1007
Drug	cyadox	CYP11B1 CYP11B2	9.59e-06	2	71	2	ctd:C020728
Drug	18-hydroxydeoxycorticosterone	CYP11B1 CYP11B2	9.59e-06	2	71	2	ctd:C042509
Disease	adrenal cortical adenoma (is_marker_for)	CYP11B1 CYP11B2	5.71e-06	2	71	2	DOID:0050891 (is_marker_for)
Disease	Glucocorticoid-remediable aldosteronism	CYP11B1 CYP11B2	5.71e-06	2	71	2	C1260386
Disease	congenital adrenal hyperplasia (implicated_via_orthology)	CYP11B1 CYP11B2	1.71e-05	3	71	2	DOID:0050811 (implicated_via_orthology)
Disease	primary hyperaldosteronism (is_implicated_in)	CYP11B1 CYP11B2	5.68e-05	5	71	2	DOID:446 (is_implicated_in)
Disease	Conn Syndrome	CYP11B1 CYP11B2	8.51e-05	6	71	2	C1384514
Disease	Hyperaldosteronism	CYP11B1 CYP11B2	8.51e-05	6	71	2	C0020428
Disease	1-eicosatrienoylglycerophosphocholine measurement	SLCO1A2 MUSK	1.19e-04	7	71	2	EFO_0021081
Disease	protocadherin alpha-7 measurement	CYP11B1 CYP11B2	1.19e-04	7	71	2	EFO_0801973
Disease	tumor necrosis factor ligand superfamily member 6, soluble form measurement	RNF123 CELSR3	1.19e-04	7	71	2	EFO_0020797
Disease	2-arachidonoyl-GPE (20:4) measurement	SLCO1A2 MUSK	1.58e-04	8	71	2	EFO_0800260
Disease	1-linoleoyl-GPE (18:2) measurement	SLCO1A2 MUSK	1.58e-04	8	71	2	EFO_0800247
Disease	protein FAM163B measurement	CYP11B1 CYP11B2	2.03e-04	9	71	2	EFO_0802936
Disease	androstenedione measurement	CYP11B1 CYP11B2	2.54e-04	10	71	2	EFO_0007972
Disease	3-hydroxyanthranilate 3,4-dioxygenase measurement	CYP11B1 CYP11B2	3.10e-04	11	71	2	EFO_0021862
Disease	cell growth regulator with EF hand domain protein 1 measurement	CYP11B1 CYP11B2	3.10e-04	11	71	2	EFO_0801461
Disease	Hermansky-Pudlak syndrome (implicated_via_orthology)	CCZ1B CCZ1	5.10e-04	14	71	2	DOID:3753 (implicated_via_orthology)
Disease	age at menopause	CCZ1B TNRC18 TTC28 CCZ1 TAPBP	8.15e-04	302	71	5	EFO_0004704
Disease	phosphatidylserines measurement	ASCC3 MUSK	1.40e-03	23	71	2	EFO_0020049
Disease	gamma-linolenic acid measurement	CHGA MUSK	1.52e-03	24	71	2	EFO_0007762
Disease	apolipoprotein L1 measurement	CYP11B1 CYP11B2	1.65e-03	25	71	2	EFO_0021854
Disease	lysophosphatidylethanolamine 20:4 measurement	SLCO1A2 MUSK	2.22e-03	29	71	2	EFO_0010370

Protein segments in the cluster

Peptide	Gene	Start	Entry
RPNRSGRYEAAFPFL	C8orf82	81	Q6P1X6
GPPGTRLENAYRAFV	CXorf65	81	A6NEN9
GGFYALSPYPGLRLI	SMPD1	366	P17405
GQLDGYRGRPFPLAL	CYP2W1	156	Q8TAV3
PRRATYFLAGLGLGP	CARNS1	46	A5YM72
LEGNPLFGRYPFIFS	CLIP4	11	Q8N3C7
RFPAFGFGARIPPNF	CPNE6	356	O95741
YGQGRNPFFLEPAII	INTS6	111	Q9UL03
RVLYPALGPDGSAFF	PCDHGB6	561	Q9Y5F9
PLAGFGYGLPISRLY	PDK1	351	Q15118
FLGYPRIVGLSLFPN	LRRC9	41	Q6ZRR7
ELFSQLRRYGLSPGP	LEMD3	16	Q9Y2U8
PLAGFGYGLPISRLY	PDK4	326	Q16654
AGGEFLLRYARVAPP	RENBP	96	P51606
FGPGLFIYLRPGSRD	OR10G7	251	Q8NGN6
GLRFRLAGFPRKPYE	LOXL3	41	P58215
GELLFFRQREGPFYP	MCTS1	66	Q9ULC4
GFPVRLPFQGFIDRY	MYO15A	1831	Q9UKN7
PQPNRALSFFVGYGV	MGST1	126	P10620
LGPRGYDPNRYRLHF	GNL1	71	P36915
GLPPFRAGNEYLIFQ	PDPK2P	251	Q6A1A2
GLAPRPRANVTGYFS	ARHGAP32	1706	A7KAX9
AAFLANPRGFYRPGA	GAL3ST4	186	Q96RP7
YAARPFALERPFGNV	GALNT14	371	Q96FL9
RSPLGYGYVNFRFPA	PABPC5	56	Q96DU9
LLRLFEYGGFPPEAN	PPP1CB	71	P62140
PPALGFSRFPAGARY	C6orf132	1031	Q5T0Z8
PPRYQIAIRACFLGF	ICMT	61	O60725
LGAAFPLGYQAFRRP	FFAR1	106	O14842
PAAGLASYPELRLFG	CRTAP	96	O75718
PPALLSFFIYNPRFG	CCZ1	21	P86791
SFFIYNPRFGPREGQ	CCZ1	26	P86791
FLYSLGRNPALFPRP	CYP11B1	406	P15538
PPALLSFFIYNPRFG	CCZ1B	21	P86790
SFFIYNPRFGPREGQ	CCZ1B	26	P86790
LNFGAYLGLPAFLLP	PRMT5	111	O14744
EPQRLFYGNAGYRLP	BMF	91	Q96LC9
PFRKLQFGRYPGAFD	FKTN	201	O75072
QFGRYPGAFDRPELQ	FKTN	206	O75072
FLYSLGRNAALFPRP	CYP11B2	406	P19099
ANLRYRFVGPPAARA	CELSR3	466	Q9NYQ7
RAAGPLQLRFSPYVF	PSMB1	21	P20618
PGIRPYLATLAGNFR	DGAT2	186	Q96PD7
YGRCLGFQFTPAIRP	LIPE	466	Q05469
GLFRRYGSTVPAPNF	MEF2D	126	Q14814
RRGDQNPPSYLFCGL	RGMB	151	Q6NW40
ESGYPRLPLLAGFFL	TPSG1	276	Q9NRR2
LYGASGPFQRAALPV	MSX1	271	P28360
EAPFGPSGYRLRLFF	SLC35G2	156	Q8TBE7
PFFPYGVKFLAVRNG	PKHD1	2021	P08F94
RVFAGIPAPIYFGAL	SLCO1A2	556	P46721
PTYFRPNGRFLDGGL	PLA2G6	641	O60733
FSPPRAGRHFGYRVL	ITGAL	36	P20701
GYAVNPARDFGPRLF	AQP3	211	Q92482
YIGLFFFDGRFRPVP	ASCC3	666	Q8N3C0
FFDGRFRPVPLGQTF	ASCC3	671	Q8N3C0
FRARAYGFRGPGPQL	CHGA	376	P10645
GPARGPRSGLAAYFF	CMTM6	16	Q9NX76
PRSGLAAYFFMGRLP	CMTM6	21	Q9NX76
VFLSAGRPNLPYIGR	TNRC18	2826	O15417
RGGASNFPYYRRIAP	ZBTB5	526	O15062
QRFRQFGYHDTPGPR	ZSCAN21	46	Q9Y5A6
AFNFGSRPLRYPVAG	RNF123	246	Q5XPI4
PAGALQAAFRRYPRG	TAPBP	71	O15533
FPTAYDLLGAFQPGR	THEMIS2	331	Q5TEJ8
LFLGALRAFPQDRPF	TNFRSF8	11	P28908
RRGFPGVYIGPSFYQ	TMPRSS12	296	Q86WS5
GPPDIRGRAYFYALL	SLC35G6	96	P0C7Q6
RPVAGYLSPRDFLAG	TPH2	276	Q8IWU9
ARPLRLPSGNGYKFL	TTC28	2456	Q96AY4
RRSGAFYLPGLAPVN	TM9SF2	31	Q99805
PFRRLGVYIDFPGGI	TRIM16	491	O95361
LGRPVASRYADGLFP	VWA3B	71	Q502W6
SRLGLAYRGFPDQPS	UBQLN3	141	Q9H347
GRSLDLLYAFQAPGP	RNF39	381	Q9H2S5
GGYRLLGNPRAPRFS	ZNF541	741	Q9H0D2
FGRVFQARAPGLLPY	MUSK	586	O15146