Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransporter activity

SLC32A1 SLC7A2 ABCA2 SLC44A1 ATP8B4 ATP8A1 PSEN1 ATP11B KCNJ2 SLC35B4 KCNJ13 KCNJ14 SIDT1 SLC35F6 SCNN1G SLC35F2 ATP11C AQP1 SVOPL SLC44A3

4.58e-0812897620GO:0005215
GeneOntologyMolecularFunctionATPase-coupled intramembrane lipid transporter activity

ABCA2 ATP8B4 ATP8A1 ATP11B ATP11C

6.41e-0828765GO:0140326
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC32A1 SLC7A2 ABCA2 SLC44A1 ATP8A1 PSEN1 ATP11B KCNJ2 SLC35B4 KCNJ13 KCNJ14 SIDT1 SLC35F6 SCNN1G SLC35F2 AQP1 SVOPL SLC44A3

3.22e-0711807618GO:0022857
GeneOntologyMolecularFunctionfloppase activity

ABCA2 ATP8A1 ATP11B ATP11C

3.41e-0716764GO:0140328
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ABCA2 ATP8B4 ATP8A1 ATP11B ATP11C

1.43e-0651765GO:0140303
GeneOntologyMolecularFunctionphosphatidylserine floppase activity

ATP8A1 ATP11B ATP11C

4.38e-069763GO:0090556
GeneOntologyMolecularFunctionlipopeptide binding

TLR10 CD1C TLR1

6.24e-0610763GO:0071723
GeneOntologyMolecularFunctionglycerophospholipid flippase activity

ATP8A1 ATP11B ATP11C

1.87e-0514763GO:0140333
GeneOntologyMolecularFunctionflippase activity

ATP8A1 ATP11B ATP11C

3.47e-0517763GO:0140327
GeneOntologyMolecularFunctioncholine kinase activity

ETNK2 CHKA

4.28e-053762GO:0004103
GeneOntologyMolecularFunctionethanolamine kinase activity

ETNK2 CHKA

8.54e-054762GO:0004305
GeneOntologyMolecularFunctionToll-like receptor 2 binding

TLR10 TLR1

8.54e-054762GO:0035663
GeneOntologyMolecularFunctionphosphatidylserine flippase activity

ATP8A1 ATP11C

1.42e-045762GO:0140346
GeneOntologyMolecularFunctionbitter taste receptor activity

TAS2R13 TAS2R33 TAS2R36

1.45e-0427763GO:0033038
GeneOntologyMolecularFunctioninward rectifier potassium channel activity

KCNJ2 KCNJ13 KCNJ14

1.62e-0428763GO:0005242
GeneOntologyMolecularFunctionToll-like receptor binding

TLR10 TLR1 UNC93B1

1.80e-0429763GO:0035325
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

KCNJ2 KCNJ13 KCNJ14 SCNN1G AQP1

1.95e-04140765GO:0099094
GeneOntologyMolecularFunctiontaste receptor activity

TAS2R13 TAS2R33 TAS2R36

2.66e-0433763GO:0008527
GeneOntologyMolecularFunctionorganic cation transmembrane transporter activity

SLC32A1 SLC7A2 SLC44A1 SLC44A3

2.84e-0483764GO:0015101
GeneOntologyMolecularFunctionphosphatidylethanolamine flippase activity

ATP11B ATP11C

2.97e-047762GO:0090555
GeneOntologyMolecularFunctionaminophospholipid flippase activity

ATP8A1 ATP11C

2.97e-047762GO:0015247
GeneOntologyMolecularFunctioncholine transmembrane transporter activity

SLC44A1 SLC44A3

3.94e-048762GO:0015220
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR7D4 TAS2R13 GPR158 TAS2R33 TAS2R36 MRGPRG RXFP4 ADGRV1 ACKR4 CHRM4 OR9A1P

4.95e-048847611GO:0004930
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

KCNJ2 KCNJ13 KCNJ14 SCNN1G AQP1

8.49e-04193765GO:0015276
GeneOntologyMolecularFunctionlipid transporter activity

ABCA2 ATP8B4 ATP8A1 ATP11B ATP11C

9.10e-04196765GO:0005319
GeneOntologyMolecularFunctionligand-gated channel activity

KCNJ2 KCNJ13 KCNJ14 SCNN1G AQP1

9.31e-04197765GO:0022834
GeneOntologyMolecularFunctionUDP-glucosyltransferase activity

GYG1 UGCG

1.09e-0313762GO:0035251
GeneOntologyMolecularFunctionG protein-coupled neurotransmitter receptor activity

GPR158 CHRM4

1.09e-0313762GO:0099528
GeneOntologyMolecularFunctionpotassium channel activity

KCNJ2 KCNJ13 KCNJ14 AQP1

1.45e-03128764GO:0005267
GeneOntologyMolecularFunctionNAD+ nucleotidase, cyclic ADP-ribose generating

TLR10 TLR1

1.66e-0316762GO:0061809
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

TLR10 OR7D4 TAS2R13 GPR158 TAS2R33 TAS2R36 TLR1 MRGPRG RXFP4 ADGRV1 ACKR4 CHRM4 OR9A1P

1.67e-0313537613GO:0004888
GeneOntologyMolecularFunctionmonoatomic cation channel activity

PSEN1 KCNJ2 KCNJ13 KCNJ14 SCNN1G AQP1

1.96e-03343766GO:0005261
GeneOntologyMolecularFunctionphospholipid transporter activity

ATP8A1 ATP11B ATP11C

2.83e-0374763GO:0005548
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC32A1 ATP8A1 PSEN1 ATP11B KCNJ2 KCNJ13 KCNJ14 SCNN1G AQP1

3.10e-03793769GO:0015075
GeneOntologyMolecularFunctionglucosyltransferase activity

GYG1 UGCG

3.14e-0322762GO:0046527
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC32A1 ATP8A1 PSEN1 KCNJ2 KCNJ13 KCNJ14 SCNN1G AQP1

3.70e-03664768GO:0008324
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

KCNJ2 KCNJ13 KCNJ14 AQP1

3.79e-03167764GO:0015079
GeneOntologyBiologicalProcesslipid translocation

ABCA2 ATP8B4 ATP8A1 ATP11B ATP11C XKR5

8.75e-0860766GO:0034204
GeneOntologyBiologicalProcessregulation of membrane lipid distribution

ABCA2 ATP8B4 ATP8A1 ATP11B ATP11C XKR5

1.42e-0765766GO:0097035
GeneOntologyBiologicalProcessphospholipid translocation

ATP8B4 ATP8A1 ATP11B ATP11C XKR5

1.79e-0655765GO:0045332
GeneOntologyBiologicalProcessaminophospholipid transport

ATP8A1 ATP11B ATP11C

3.97e-069763GO:0015917
GeneOntologyBiologicalProcessmembrane organization

ABCA2 ATP8B4 NOX1 ATP8A1 ATP11B SYNJ2 GET1 UGCG SLC35F6 SYP ATP11C SPG11 TMCC1 XKR5

5.40e-069147614GO:0061024
GeneOntologyBiologicalProcesscholine transport

SLC44A1 PSEN1 SLC44A3

5.66e-0610763GO:0015871
GeneOntologyBiologicalProcessphospholipid biosynthetic process

ABCA2 SLC44A1 SRD5A3 SYNJ2 SERINC1 ETNK2 CHKA SLC44A3

6.43e-06268768GO:0008654
GeneOntologyBiologicalProcesslipid biosynthetic process

MLXIPL ABCA2 SLC44A1 FADS3 SRD5A3 SYNJ2 SERINC1 ETNK2 UGCG CHKA FGF19 SLC44A3

3.95e-058137612GO:0008610
GeneOntologyBiologicalProcessphospholipid transport

ATP8B4 ATP8A1 ATP11B ATP11C XKR5

4.51e-05106765GO:0015914
GeneOntologyBiologicalProcesssensory perception of taste

TAS2R13 TAS2R33 TAS2R36 SCNN1G

1.30e-0470764GO:0050909
GeneOntologyBiologicalProcessphospholipid metabolic process

ABCA2 SLC44A1 SRD5A3 SYNJ2 SERINC1 ETNK2 CHKA SLC44A3

1.32e-04410768GO:0006644
GeneOntologyBiologicalProcessimport into cell

SLC7A2 ABCA2 DNAJC13 ATP8A1 PSEN1 SYNJ2 KCNJ2 KCNJ13 KCNJ14 SCNN1G SYP SPG11 XKR5

1.38e-0410747613GO:0098657
GeneOntologyBiologicalProcessphosphatidylcholine biosynthetic process

SLC44A1 CHKA SLC44A3

1.82e-0430763GO:0006656
GeneOntologyBiologicalProcessorganic cation transport

SLC32A1 SLC7A2 SLC44A1 PSEN1 SLC44A3

1.98e-04145765GO:0015695
GeneOntologyBiologicalProcessimport across plasma membrane

SLC7A2 PSEN1 KCNJ2 KCNJ13 KCNJ14 SCNN1G

2.05e-04230766GO:0098739
GeneOntologyBiologicalProcessaminophospholipid translocation

ATP8A1 ATP11C

2.78e-047762GO:0140331
GeneOntologyBiologicalProcesstransport across blood-brain barrier

SLC7A2 ABCA2 SLC44A1 ATP8A1

3.01e-0487764GO:0150104
GeneOntologyBiologicalProcesstoll-like receptor signaling pathway

TLR10 TLR1 UNC93B1 IKBKB

3.14e-0488764GO:0002224
GeneOntologyBiologicalProcessvascular transport

SLC7A2 ABCA2 SLC44A1 ATP8A1

3.14e-0488764GO:0010232
GeneOntologyBiologicalProcessorganophosphate ester transport

ATP8B4 ATP8A1 ATP11B ATP11C XKR5

3.31e-04162765GO:0015748
GeneOntologyBiologicalProcessnegative regulation of low-density lipoprotein receptor activity

ABCA2 PSEN1

3.70e-048762GO:1905598
GeneOntologyBiologicalProcesscholine metabolic process

SLC44A1 CHKA

3.70e-048762GO:0019695
GeneOntologyBiologicalProcesslipid transport

ABCA2 ATP8B4 ATP8A1 ATP11B ATP11C SPG11 CHKA XKR5

5.42e-04506768GO:0006869
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of bitter taste

TAS2R13 TAS2R33 TAS2R36

5.71e-0444763GO:0001580
GeneOntologyBiologicalProcessphosphatidylethanolamine biosynthetic process

ETNK2 CHKA

5.92e-0410762GO:0006646
GeneOntologyBiologicalProcesscellular response to bacterial lipoprotein

TLR10 TLR1

5.92e-0410762GO:0071220
GeneOntologyBiologicalProcesscellular response to bacterial lipopeptide

TLR10 TLR1

5.92e-0410762GO:0071221
GeneOntologyBiologicalProcessresponse to bacterial lipopeptide

TLR10 TLR1

5.92e-0410762GO:0070339
GeneOntologyBiologicalProcessNotch receptor processing

PSEN1 PSENEN

5.92e-0410762GO:0007220
GeneOntologyBiologicalProcessresponse to bacterial lipoprotein

TLR10 TLR1

7.21e-0411762GO:0032493
GeneOntologyBiologicalProcessregulation of resting membrane potential

PSEN1 KCNJ2

7.21e-0411762GO:0060075
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SLC32A1 ATP8A1 PSEN1 ATP11B KCNJ2 KCNJ13 KCNJ14 ASPH SCNN1G ATP11C IKBKB AQP1

7.38e-0411157612GO:0034220
GeneOntologyBiologicalProcesssensory perception of bitter taste

TAS2R13 TAS2R33 TAS2R36

7.38e-0448763GO:0050913
GeneOntologyBiologicalProcessendomembrane system organization

DNAJC13 ATP8B4 NOX1 GET1 UGCG SYP AQP1 TMCC1 XKR5

7.97e-04672769GO:0010256
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of taste

TAS2R13 TAS2R33 TAS2R36

8.32e-0450763GO:0050912
GeneOntologyBiologicalProcesspotassium ion import across plasma membrane

KCNJ2 KCNJ13 KCNJ14

8.82e-0451763GO:1990573
GeneOntologyCellularComponentvacuole

TMEM150B DNASE2B CD1C ABCA2 DNAJC13 ATP8A1 PSEN1 ATP11B TMEM45B GYG1 CAPN1 SIDT1 SLC35F6 ATP11C SPG11 UNC93B1

1.42e-079137616GO:0005773
GeneOntologyCellularComponentphospholipid-translocating ATPase complex

ATP8B4 ATP8A1 ATP11B ATP11C

1.57e-0714764GO:1990531
GeneOntologyCellularComponentlysosome

DNASE2B CD1C ABCA2 DNAJC13 ATP8A1 PSEN1 ATP11B TMEM45B GYG1 CAPN1 SIDT1 SLC35F6 ATP11C SPG11 UNC93B1

1.86e-078117615GO:0005764
GeneOntologyCellularComponentlytic vacuole

DNASE2B CD1C ABCA2 DNAJC13 ATP8A1 PSEN1 ATP11B TMEM45B GYG1 CAPN1 SIDT1 SLC35F6 ATP11C SPG11 UNC93B1

1.86e-078117615GO:0000323
GeneOntologyCellularComponentvacuolar membrane

TMEM150B ABCA2 DNAJC13 ATP8A1 PSEN1 ATP11B TMEM45B SLC35F6 ATP11C SPG11

1.47e-055077610GO:0005774
GeneOntologyCellularComponentlysosomal membrane

ABCA2 DNAJC13 ATP8A1 PSEN1 ATP11B TMEM45B SLC35F6 ATP11C SPG11

4.47e-05462769GO:0005765
GeneOntologyCellularComponentlytic vacuole membrane

ABCA2 DNAJC13 ATP8A1 PSEN1 ATP11B TMEM45B SLC35F6 ATP11C SPG11

4.47e-05462769GO:0098852
GeneOntologyCellularComponentcytoplasmic vesicle membrane

TMEM150B SLC32A1 CD1C ABCA2 DNAJC13 ATP8B4 ATP8A1 PSEN1 ATP11B TMEM45B PSENEN TLR1 SYP ATP11C AQP1

6.17e-0513077615GO:0030659
GeneOntologyCellularComponentazurophil granule membrane

DNAJC13 ATP8A1 PSEN1 ATP11B

6.31e-0559764GO:0035577
GeneOntologyCellularComponentvesicle membrane

TMEM150B SLC32A1 CD1C ABCA2 DNAJC13 ATP8B4 ATP8A1 PSEN1 ATP11B TMEM45B PSENEN TLR1 SYP ATP11C AQP1

7.20e-0513257615GO:0012506
GeneOntologyCellularComponenttransporter complex

ABCA2 ATP8B4 ATP8A1 ATP11B KCNJ2 KCNJ13 KCNJ14 SCNN1G ATP11C

1.68e-04550769GO:1990351
GeneOntologyCellularComponentgamma-secretase complex

PSEN1 PSENEN

2.71e-047762GO:0070765
GeneOntologyCellularComponentendosome membrane

TMEM150B CD1C ABCA2 DNAJC13 PSEN1 ATP11B TMEM45B PSENEN ATP11C

3.28e-04602769GO:0010008
GeneOntologyCellularComponentsarcolemma

PSEN1 KCNJ2 ITGA7 AQP1 CHRM4

6.45e-04190765GO:0042383
GeneOntologyCellularComponentsperm head plasma membrane

ADAM20 ADAM29

7.02e-0411762GO:1990913
GeneOntologyCellularComponentendosome

TMEM150B CD1C ABCA2 DNAJC13 NOX1 PSEN1 ATP11B TMEM45B PSENEN ATP11C UNC93B1 ACKR4

9.77e-0411677612GO:0005768
GeneOntologyCellularComponentaxon terminus

SLC32A1 SYNJ2 SYP AQP1 CHRM4

1.01e-03210765GO:0043679
GeneOntologyCellularComponentsecretory granule membrane

DNAJC13 ATP8B4 ATP8A1 PSEN1 ATP11B AQP1

1.26e-03329766GO:0030667
GeneOntologyCellularComponentclathrin-sculpted vesicle

SLC32A1 SYP

1.51e-0316762GO:0060198
GeneOntologyCellularComponentneuron projection terminus

SLC32A1 SYNJ2 SYP AQP1 CHRM4

1.60e-03233765GO:0044306
GeneOntologyCellularComponentplasma membrane protein complex

ABCA2 NOX1 PSEN1 PSENEN KCNJ2 TLR1 KCNJ14 ITGA7 IKBKB

2.13e-03785769GO:0098797
GeneOntologyCellularComponentendoplasmic reticulum membrane

FADS3 SRD5A3 PSEN1 SERINC1 PSENEN SLC35B4 ASPH GET1 ATP11C UNC93B1 ZNRF4 TMCC1

2.33e-0312937612GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

FADS3 SRD5A3 PSEN1 SERINC1 PSENEN SLC35B4 ASPH GET1 ATP11C UNC93B1 ZNRF4 TMCC1

2.42e-0312997612GO:0098827
GeneOntologyCellularComponentazurophil granule

DNAJC13 ATP8A1 PSEN1 ATP11B

2.76e-03160764GO:0042582
GeneOntologyCellularComponentprimary lysosome

DNAJC13 ATP8A1 PSEN1 ATP11B

2.76e-03160764GO:0005766
GeneOntologyCellularComponentsperm plasma membrane

ADAM20 ADAM29

2.87e-0322762GO:0097524
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

FADS3 SRD5A3 PSEN1 SERINC1 PSENEN SLC35B4 ASPH GET1 ATP11C UNC93B1 ZNRF4 TMCC1

2.89e-0313277612GO:0042175
GeneOntologyCellularComponentpresynaptic membrane

PSEN1 GPR158 PSENEN SYP CHRM4

3.38e-03277765GO:0042734
GeneOntologyCellularComponentpresynapse

SLC32A1 ATP8A1 PSEN1 SYNJ2 GPR158 PSENEN SYP AQP1 CHRM4

4.75e-03886769GO:0098793
GeneOntologyCellularComponentdistal axon

SLC32A1 PSEN1 SYNJ2 SYP AQP1 CHRM4

5.03e-03435766GO:0150034
GeneOntologyCellularComponentsperm head

ADAM20 ADAM29

5.31e-0330762GO:0061827
HumanPhenoPerifolliculitis

PSEN1 PSENEN

2.31e-052252HP:0012322
HumanPhenoAcne inversa

PSEN1 PSENEN IKBKB

2.89e-0513253HP:0040154
DomainP_typ_ATPase_c

ATP8B4 ATP8A1 ATP11B ATP11C

1.97e-0714724IPR032630
DomainP-type_ATPase_N

ATP8B4 ATP8A1 ATP11B ATP11C

1.97e-0714724IPR032631
DomainP-type_ATPase_IV

ATP8B4 ATP8A1 ATP11B ATP11C

1.97e-0714724IPR006539
DomainPhoLip_ATPase_C

ATP8B4 ATP8A1 ATP11B ATP11C

1.97e-0714724PF16212
DomainPhoLip_ATPase_N

ATP8B4 ATP8A1 ATP11B ATP11C

1.97e-0714724PF16209
Domain-

ATP8B4 ATP8A1 ATP11B ATP11C

6.73e-06327243.40.1110.10
Domain-

ATP8B4 ATP8A1 ATP11B ATP11C

6.73e-06327242.70.150.10
DomainATPase_P-typ_cyto_domN

ATP8B4 ATP8A1 ATP11B ATP11C

9.71e-0635724IPR023299
DomainP_typ_ATPase

ATP8B4 ATP8A1 ATP11B ATP11C

1.09e-0536724IPR001757
DomainATPase_P-typ_P_site

ATP8B4 ATP8A1 ATP11B ATP11C

1.09e-0536724IPR018303
DomainATPASE_E1_E2

ATP8B4 ATP8A1 ATP11B ATP11C

1.09e-0536724PS00154
DomainATPase_P-typ_transduc_dom_A

ATP8B4 ATP8A1 ATP11B ATP11C

1.22e-0537724IPR008250
DomainE1-E2_ATPase

ATP8B4 ATP8A1 ATP11B ATP11C

1.22e-0537724PF00122
DomainK_chnl_inward-rec_Kir_cyto

KCNJ2 KCNJ13 KCNJ14

2.97e-0516723IPR013518
DomainIRK

KCNJ2 KCNJ13 KCNJ14

2.97e-0516723PF01007
Domain-

KCNJ2 KCNJ13 KCNJ14

2.97e-05167232.60.40.1400
DomainK_chnl_inward-rec_Kir

KCNJ2 KCNJ13 KCNJ14

2.97e-0516723IPR016449
DomainSLC35_F1/F2/F6

SLC35F6 SLC35F2

8.75e-054722IPR009262
DomainSLC35F

SLC35F6 SLC35F2

8.75e-054722PF06027
Domain-

ATP8B4 ATP8A1 ATP11B ATP11C

1.08e-04647243.40.50.1000
DomainToll-like_receptor

TLR10 TLR1

1.45e-045722IPR017241
DomainCholine_transpo

SLC44A1 SLC44A3

1.45e-045722PF04515
DomainCholine_transptr-like

SLC44A1 SLC44A3

1.45e-045722IPR007603
DomainHAD-like_dom

ATP8B4 ATP8A1 ATP11B ATP11C

2.45e-0479724IPR023214
DomainDisintegrin_CS

ADAM20 ADAM29

1.70e-0316722IPR018358
DomainADAM_CR

ADAM20 ADAM29

2.15e-0318722PF08516
Domain-

ADAM20 ADAM29

2.66e-03207224.10.70.10
DomainDisintegrin

ADAM20 ADAM29

2.94e-0321722PF00200
DomainDISIN

ADAM20 ADAM29

2.94e-0321722SM00050
DomainTIR

TLR10 TLR1

2.94e-0321722SM00255
DomainTIR

TLR10 TLR1

3.22e-0322722PF01582
Domain-

TLR10 TLR1

3.52e-03237223.40.50.10140
DomainTIR

TLR10 TLR1

3.83e-0324722PS50104
DomainTIR_dom

TLR10 TLR1

4.15e-0325722IPR000157
DomainACR

ADAM20 ADAM29

4.83e-0327722SM00608
DomainADAM_Cys-rich

ADAM20 ADAM29

4.83e-0327722IPR006586
DomainIg_E-set

KCNJ2 KCNJ13 KCNJ14

7.57e-03104723IPR014756
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC32A1 SLC7A2 ABCA2 SLC44A1 ATP8B4 ATP8A1 ATP11B SLC35B4 ASPH SCNN1G ATP11C AQP1 SLC44A3

5.58e-067365713M27287
PathwayREACTOME_DISEASES_OF_IMMUNE_SYSTEM

TLR10 TLR1 UNC93B1 IKBKB

7.94e-0632574M27428
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC32A1 ABCA2 SLC44A1 ATP8B4 ATP8A1 ATP11B SLC35B4 ASPH SCNN1G ATP11C AQP1 SLC44A3

1.40e-056815712MM14985
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

ATP8B4 ATP8A1 ATP11B ATP11C

7.03e-0555574M971
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ATP8B4 ATP8A1 ATP11B ASPH SCNN1G ATP11C

7.44e-05176576MM15718
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

ATP8B4 ATP8A1 ATP11B ATP11C

8.09e-0557574MM15643
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ATP8B4 ATP8A1 ATP11B ASPH SCNN1G ATP11C

9.24e-05183576M997
PathwayREACTOME_SYNTHESIS_OF_PC

SLC44A1 CHKA SLC44A3

1.53e-0426573MM14584
PathwayREACTOME_SYNTHESIS_OF_PC

SLC44A1 CHKA SLC44A3

1.91e-0428573M684
PathwayREACTOME_NONCANONICAL_ACTIVATION_OF_NOTCH3

PSEN1 PSENEN

3.33e-047572MM15612
PathwayREACTOME_NONCANONICAL_ACTIVATION_OF_NOTCH3

PSEN1 PSENEN

4.43e-048572M27887
PathwayREACTOME_TGFBR3_PTM_REGULATION

PSEN1 PSENEN

7.08e-0410572MM17232
PathwayREACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR

PSEN1 PSENEN

7.08e-0410572MM14744
PathwayREACTOME_METABOLISM_OF_LIPIDS

SLC44A1 SRD5A3 SYNJ2 ETNK2 ACBD5 UGCG HELZ2 CHKA SLC44A3

7.89e-04620579MM15193
PathwayREACTOME_TGFBR3_PTM_REGULATION

PSEN1 PSENEN

8.63e-0411572M48251
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION

PSEN1 PSENEN

8.63e-0411572M47865
PathwayWP_INCLUSION_BODY_MYOSITIS

PSEN1 PSENEN

8.63e-0411572M42545
PathwayREACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR

PSEN1 PSENEN

8.63e-0411572M2661
PathwayREACTOME_NOTCH4_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

PSEN1 PSENEN

8.63e-0411572M27882
PathwayREACTOME_NUCLEAR_SIGNALING_BY_ERBB4

PSEN1 PSENEN

8.63e-0411572MM14534
PathwayREACTOME_SENSORY_PERCEPTION_OF_TASTE

TAS2R13 KCNJ2 SCNN1G

8.96e-0447573M42524
PathwayREACTOME_SYNTHESIS_OF_PE

ETNK2 CHKA

1.03e-0312572MM14586
PathwayREACTOME_PHOSPHOLIPID_METABOLISM

SLC44A1 SYNJ2 ETNK2 CHKA SLC44A3

1.15e-03196575MM14591
PathwayREACTOME_SYNTHESIS_OF_PE

ETNK2 CHKA

1.22e-0313572M656
PathwayREACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS

SLC44A1 ETNK2 CHKA SLC44A3

1.39e-03120574MM14585
PathwayREACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS

PSEN1 PSENEN

1.42e-0314572MM14826
PathwayWP_KENNEDY_PATHWAY

ETNK2 CHKA

1.42e-0314572MM15980
PathwayWP_KENNEDY_PATHWAY_FROM_SPHINGOLIPIDS

ETNK2 CHKA

1.42e-0314572M39620
PathwayREACTOME_PHOSPHOLIPID_METABOLISM

SLC44A1 SYNJ2 ETNK2 CHKA SLC44A3

1.59e-03211575M649
PathwayREACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS

SLC44A1 ETNK2 CHKA SLC44A3

1.77e-03128574M706
Pubmed

Differential expression of putative transbilayer amphipath transporters.

ATP8B4 ATP8A1 ATP11B ATP11C

1.48e-081376411015572
Pubmed

The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease.

ATP8A1 ATP11B ATP11C

1.19e-061076315919184
Pubmed

ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner.

ATP8A1 ATP11B ATP11C

2.17e-061276321914794
Pubmed

International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.

KCNJ2 KCNJ13 KCNJ14

4.48e-061576316382105
Pubmed

Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities.

PSEN1 PSENEN

4.71e-06276226559975
Pubmed

Pen-2 and Presenilin are Sufficient to Catalyze Notch Processing.

PSEN1 PSENEN

4.71e-06276228234257
Pubmed

Toll-like receptor 1 and 10 polymorphisms, Helicobacter pylori susceptibility and risk of gastric lesions in a high-risk Chinese population.

TLR10 TLR1

4.71e-06276225687912
Pubmed

Compensatory remodeling of a septo-hippocampal GABAergic network in the triple transgenic Alzheimer's mouse model.

SLC32A1 PSEN1

4.71e-06276237061718
Pubmed

Polymorphisms at Locus 4p14 of Toll-Like Receptors TLR-1 and TLR-10 Confer Susceptibility to Gastric Carcinoma in Helicobacter pylori Infection.

TLR10 TLR1

4.71e-06276226559190
Pubmed

Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping.

PSEN1 PSENEN

4.71e-06276227220847
Pubmed

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.

PSEN1 PSENEN

4.71e-06276220534834
Pubmed

Toll-like receptor 1 and 10 variations increase asthma risk and review highlights further research directions.

TLR10 TLR1

4.71e-06276230924193
Pubmed

Genetic absence of the vesicular inhibitory amino acid transporter differentially regulates respiratory and locomotor motor neuron development.

SLC32A1 SYP

4.71e-06276224276495
Pubmed

Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein.

PSEN1 PSENEN

4.71e-06276222689582
Pubmed

Toll-like receptor 1 and 10 gene polymorphisms are linked to postbronchiolitis asthma in adolescence.

TLR10 TLR1

4.71e-06276228692144
Pubmed

Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1.

PSEN1 PSENEN

4.71e-06276216234244
Pubmed

Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2.

PSEN1 PSENEN

4.71e-06276216234243
Pubmed

Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface.

PSEN1 PSENEN

4.71e-06276232631487
Pubmed

The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine.

SLC35B4 SLC35F6

4.71e-06276215911612
Pubmed

Human Papillomavirus L2 Capsid Protein Stabilizes γ-Secretase during Viral Infection.

PSEN1 PSENEN

4.71e-06276235458534
Pubmed

Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase.

PSEN1 PSENEN

4.71e-06276225673856
Pubmed

Genetic polymorphisms in TLR1, TLR2, TLR4, and TLR10 of Helicobacter pylori-associated gastritis: a prospective cross-sectional study in Thailand.

TLR10 TLR1

4.71e-06276228368946
Pubmed

Mutations in the γ-secretase genes PSEN1, PSENEN, and NCSTN in a family with acne inversa.

PSEN1 PSENEN

1.41e-05376230105992
Pubmed

Gamma-secretase gene mutations in familial acne inversa.

PSEN1 PSENEN

1.41e-05376220929727
Pubmed

Amyloid β-induced astrogliosis is mediated by β1-integrin via NADPH oxidase 2 in Alzheimer's disease.

NOX1 PSEN1

1.41e-05376227709751
Pubmed

Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk.

TLR10 TLR1

1.41e-05376218752252
Pubmed

Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease.

TLR10 TLR1

1.41e-05376225028161
Pubmed

γ-Secretase mutations in hidradenitis suppurativa: new insights into disease pathogenesis.

PSEN1 PSENEN

1.41e-05376223096707
Pubmed

The role of presenilin cofactors in the gamma-secretase complex.

PSEN1 PSENEN

1.41e-05376212660785
Pubmed

[Association of polymorphisms in toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan].

TLR10 TLR1

1.41e-05376225850295
Pubmed

Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum.

SLC32A1 SYP

1.41e-05376217134779
Pubmed

Genetic variation in the Toll-like receptor gene cluster (TLR10-TLR1-TLR6) influences disease course in sarcoidosis.

TLR10 TLR1

1.41e-05376222150367
Pubmed

Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex.

PSEN1 PSENEN

1.41e-05376225614624
Pubmed

Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum.

PSEN1 PSENEN

1.41e-05376234292306
Pubmed

Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes.

PSEN1 PSENEN

1.41e-05376219036728
Pubmed

Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk.

TLR10 TLR1

1.41e-05376215812078
Pubmed

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

PSEN1 PSENEN

1.41e-05376212522139
Pubmed

Epistatic effect of TLR-1, -6 and -10 polymorphisms on organic dust-mediated cytokine response.

TLR10 TLR1

1.41e-05376228123183
Pubmed

Alzheimer's disease-linked presenilin mutation (PS1M146L) induces filamin expression and γ-secretase independent redistribution.

PSEN1 PSENEN

1.41e-05376220847418
Pubmed

G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.

PSEN1 PSENEN

1.41e-05376225394380
Pubmed

Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease.

TLR10 TLR1

1.41e-05376218091991
Pubmed

Activation and intrinsic gamma-secretase activity of presenilin 1.

PSEN1 PSENEN

1.41e-05376221115843
Pubmed

Association between Toll-like receptor gene cluster (TLR6, TLR1, and TLR10) and prostate cancer.

TLR10 TLR1

1.41e-05376217932345
Pubmed

Mutations in the γ-secretase genes NCSTN, PSENEN, and PSEN1 underlie rare forms of hidradenitis suppurativa (acne inversa).

PSEN1 PSENEN

1.41e-05376222622421
Pubmed

Variation in the TLR10/TLR1/TLR6 locus is the major genetic determinant of interindividual difference in TLR1/2-mediated responses.

TLR10 TLR1

1.41e-05376223151486
Pubmed

Membrane topology of gamma-secretase component PEN-2.

PSEN1 PSENEN

1.41e-05376212639958
Pubmed

Rare independent mutations in renal salt handling genes contribute to blood pressure variation.

KCNJ2 KCNJ13 KCNJ14

1.50e-052276318391953
Pubmed

Toll-like receptor heterodimer variants protect from childhood asthma.

TLR10 TLR1

2.82e-05476218547625
Pubmed

The physiological roles of vesicular GABA transporter during embryonic development: a study using knockout mice.

SLC32A1 SYP

2.82e-05476221190592
Pubmed

Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex.

PSEN1 PSENEN

2.82e-05476216371134
Pubmed

Meat and fiber intake and interaction with pattern recognition receptors (TLR1, TLR2, TLR4, and TLR10) in relation to colorectal cancer in a Danish prospective, case-cohort study.

TLR10 TLR1

2.82e-05476229566186
Pubmed

Structural basis of human γ-secretase assembly.

PSEN1 PSENEN

2.82e-05476225918421
Pubmed

A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.

SLC32A1 SYP

2.82e-05476217823315
Pubmed

Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes.

PSEN1 PSENEN

2.82e-05476215322109
Pubmed

Active gamma-secretase complexes contain only one of each component.

PSEN1 PSENEN

2.82e-05476217911105
Pubmed

Reconstitution of gamma-secretase activity.

PSEN1 PSENEN

2.82e-05476212679784
Pubmed

Acetylcholine controls GABA-, glutamate-, and glycine-dependent giant depolarizing potentials that govern spontaneous motoneuron activity at the onset of synaptogenesis in the mouse embryonic spinal cord.

SLC32A1 SYP

2.82e-05476224790209
Pubmed

Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2.

KCNJ2 KCNJ14

2.82e-05476215958527
Pubmed

Polymorphisms in the toll-like receptor 2 subfamily and risk of asthma: a case-control analysis in a Chinese population.

TLR10 TLR1

2.82e-05476220815312
Pubmed

Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling.

TLR10 TLR1

2.82e-05476220348427
Pubmed

An atomic structure of human γ-secretase.

PSEN1 PSENEN

2.82e-05476226280335
Pubmed

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.

PSEN1 PSENEN

2.82e-05476212198112
Pubmed

p53-dependent control of transactivation of the Pen2 promoter by presenilins.

PSEN1 PSENEN

2.82e-05476219889971
Pubmed

An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins.

SLC44A1 SLC44A3

2.82e-05476210677542
Pubmed

Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.

PSEN1 PSENEN

2.82e-05476215711015
Pubmed

Cellular FLICE-like Inhibitory Protein (c-FLIP) and PS1-associated Protein (PSAP) Mediate Presenilin 1-induced γ-Secretase-dependent and -independent Apoptosis, Respectively.

PSEN1 PSENEN

2.82e-05476226025363
Pubmed

Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease.

PSEN1 PSENEN SYP

2.82e-052776327256505
Pubmed

Dysbindin Deficiency Modifies the Expression of GABA Neuron and Ion Permeation Transcripts in the Developing Hippocampus.

SLC32A1 KCNJ13 SYP

3.52e-052976328344592
Pubmed

Biology, structure and mechanism of P-type ATPases.

ATP8A1 ATP11B ATP11C

3.52e-052976315071553
Pubmed

Calsenilin regulates presenilin 1/γ-secretase-mediated N-cadherin ε-cleavage and β-catenin signaling.

PSEN1 PSENEN

4.69e-05576221852538
Pubmed

Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates.

PSEN1 PSENEN

4.69e-05576221597003
Pubmed

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.

PSEN1 PSENEN

4.69e-05576215322084
Pubmed

Molecular characterization of the family of choline transporter-like proteins and their splice variants.

SLC44A1 SLC44A3

4.69e-05576215715662
Pubmed

Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates.

PSEN1 PSENEN

4.69e-05576214572442
Pubmed

Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production.

PSEN1 PSENEN

4.69e-05576222771797
Pubmed

Toll-like receptor gene polymorphisms confer susceptibility to graft-versus-host disease in allogenic hematopoietic stem cell transplantation.

TLR10 TLR1

4.69e-05576222703024
Pubmed

Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin.

PSEN1 PSENEN

4.69e-05576215975090
Pubmed

Presenilin/γ-secretase regulates neurexin processing at synapses.

PSEN1 SYP

4.69e-05576221559374
Pubmed

An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor.

PSEN1 PSENEN

4.69e-05576219376115
Pubmed

Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.

PSEN1 PSENEN

4.69e-05576212740439
Pubmed

Interactions of sequence variants in interleukin-1 receptor-associated kinase4 and the toll-like receptor 6-1-10 gene cluster increase prostate cancer risk.

TLR10 TLR1

4.69e-05576216537705
Pubmed

ATPase reaction cycle of P4-ATPases affects their transport from the endoplasmic reticulum.

ATP11B ATP11C

4.69e-05576231571211
Pubmed

A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma.

TLR10 TLR1

4.69e-05576219029192
Pubmed

Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer's disease.

PSEN1 CHRM4

4.69e-05576227223629
Pubmed

Cellular localization of Nicastrin affects amyloid beta species production.

PSEN1 PSENEN

4.69e-05576218201567
Pubmed

Bax inhibitor 1 is a γ-secretase-independent presenilin-binding protein.

PSEN1 PSENEN

4.69e-05576230559186
Pubmed

Structural and functional understanding of the toll-like receptors.

TLR10 TLR1

7.03e-05676233576548
Pubmed

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity.

PSEN1 PSENEN

7.03e-05676215474363
Pubmed

Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations.

PSEN1 PSENEN

7.03e-05676214717705
Pubmed

Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system.

PSEN1 PSENEN

7.03e-05676222074918
Pubmed

Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88.

TLR10 TLR1

7.03e-05676215728506
Pubmed

APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity.

PSEN1 PSENEN

7.03e-05676212763021
Pubmed

Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.

PSEN1 PSENEN

7.03e-05676220811458
Pubmed

Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin.

PSEN1 PSENEN

7.03e-05676220130175
Pubmed

Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.

PSEN1 SYP

7.03e-05676212805290
Pubmed

Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage.

PSEN1 PSENEN

7.03e-05676226094765
Pubmed

Blood-Brain Barrier: From Physiology to Disease and Back.

SLC7A2 ABCA2 SLC44A1 ATP8A1

8.51e-0510576430280653
Pubmed

Isolated Toll-like receptor transmembrane domains are capable of oligomerization.

TLR10 TLR1

9.83e-05776223155421
Pubmed

Polymorphisms of toll like receptors in the genetics of severe RSV associated diseases.

TLR10 TLR1

9.83e-05776218776592
Pubmed

A genome-wide association search for type 2 diabetes genes in African Americans.

TMEM45B SLC44A3

9.83e-05776222238593
InteractionTTYH1 interactions

ABCA2 SLC44A1 ATP8A1 GET1 SLC35F6 SLC35F2 ATP11C UNC93B1

7.48e-06300688int:TTYH1
Cytoband10p12.1

GPR158 ACBD5

1.23e-033274210p12.1
CytobandEnsembl 112 genes in cytogenetic band chr3q22

DNAJC13 ACKR4 TMCC1

1.38e-03135743chr3q22
Cytoband20q11.22

PXMP4 UQCC1

1.65e-033774220q11.22
Cytoband3q22.1

DNAJC13 TMCC1

2.12e-03427423q22.1
Cytoband4p14

TLR10 TLR1

2.12e-03427424p14
GeneFamilyATPase phospholipid transporting

ATP8B4 ATP8A1 ATP11B ATP11C

8.11e-08155241210
GeneFamilyPotassium voltage-gated channel subfamily J

KCNJ2 KCNJ13 KCNJ14

1.22e-0516523276
GeneFamilyTaste 2 receptors

TAS2R13 TAS2R33 TAS2R36

1.91e-04395231162
GeneFamilyCD molecules|Toll like receptors

TLR10 TLR1

3.60e-0410522948
GeneFamilySolute carriers

SLC32A1 SLC7A2 SLC44A1 SLC35B4 SLC35F2 SLC44A3

9.12e-04395526752
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ADAM20 ADAM29

2.72e-032752247
CoexpressionGSE13306_RA_VS_UNTREATED_TCONV_UP

PXMP4 ATP8A1 POLE UQCC1 CHKA CHRM4 SLC44A3

1.58e-06200747M3234
CoexpressionGSE20152_SPHK1_KO_VS_HTNFA_OVEREXPRESS_ANKLE_UP

SLC44A1 KCNJ13 ASPH SYP SLC35F2 ADAM29

2.02e-05197746M7682
CoexpressionGSE17721_PAM3CSK4_VS_CPG_8H_BMDC_DN

DNAJC13 ATP11B TMEM45B SLC35F6 ATP11C UNC93B1

2.20e-05200746M3866
ToppCellCOPD-Endothelial-VE_Peribronchial|Endothelial / Disease state, Lineage and Cell class

SYNJ2 KCNJ14 ASPH UGCG SLC35F2 ATP11C

8.64e-071947468dcde77767b23e75360adb316cdccf56a00e3726
ToppCellMacroglial-Oligodendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

ABCA2 SLC44A1 ATP8A1 PSEN1 SYNJ2 KCNJ2

1.03e-062007464dbac2f2587e87ca5a0622f50439bb5447e93c7f
ToppCellMacroglial-Oligodendrocytes-OPALIN--|Macroglial / cells hierarchy compared to all cells using T-Statistic

ABCA2 SLC44A1 ATP8A1 PSEN1 SYNJ2 KCNJ2

1.03e-0620074626b989e30bbbaf30904ced03f6aae3dea25c732c
ToppCellMacroglial-Oligodendrocytes-OPALIN---|Macroglial / cells hierarchy compared to all cells using T-Statistic

ABCA2 SLC44A1 ATP8A1 PSEN1 SYNJ2 KCNJ2

1.03e-062007461314664c1721e9ecb1e2c3482a039044b0fe50a9
ToppCellMacroglial-Oligodendrocytes-OPALIN-|Macroglial / cells hierarchy compared to all cells using T-Statistic

ABCA2 SLC44A1 ATP8A1 PSEN1 SYNJ2 KCNJ2

1.03e-062007468b229f095fc113aecfc94b64862a9e0fdcc363ce
ToppCellMacroglial-Oligodendrocytes-OPALIN----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

ABCA2 SLC44A1 ATP8A1 PSEN1 SYNJ2 KCNJ2

1.03e-06200746272909f4354f3ae22e2b2f8f35970e6b0e92cfe2
ToppCellMacroglial-Oligodendrocytes-OPALIN|Macroglial / cells hierarchy compared to all cells using T-Statistic

ABCA2 SLC44A1 ATP8A1 PSEN1 SYNJ2 KCNJ2

1.03e-062007465f75a9b8bcd49d9bbb1e9ce2de730eaec96369ca
ToppCell18-Distal-Epithelial-Basal_cell|Distal / Age, Tissue, Lineage and Cell class

DNAJC13 TMEM45B KCNJ2 SCNN1G ACKR4

6.64e-06158745183f445967e09e871c93d8e94781ed9fec894169
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MLXIPL SLC7A2 SYP RXFP4 ADGRV1

1.22e-05179745d70791d2a0db35a6b013fa7ed2f9f39364581eff
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TLR10 SLC32A1 UGCG SIDT1 UNC93B1

1.25e-051807456a2366d76276452141db1bd93013a9503525f574
ToppCellP03-Epithelial|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ATP8A1 KCNJ13 SCNN1G CHKA SLC44A3

1.28e-05181745de0466072f5b2ab8db3d9bab31e3205d1ff7cfb7
ToppCell10x5'v1-week_12-13-Myeloid_neutrophil-granulo-neutrophil-myelocyte|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

DNAJC13 ATP8B4 GYG1 POLE UGCG

1.32e-0518274552eac2f892ea7f26731e0b21c578fd2665a1657a
ToppCellPND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP8A1 SCNN1G CHKA AQP1 SLC44A3

1.66e-05191745ce76b156b153a2c7c9f2fb8e563b69c81073fbe5
ToppCellPND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP8A1 SCNN1G CHKA AQP1 SLC44A3

1.66e-05191745c006f5a6e3a32b79ac99a78304bdd5116fc0d5e0
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ATP8A1 TMEM45B SCNN1G ADGRV1 SLC44A3

1.70e-05192745b99f8236ef4ccdc75c02abea381cae6453205f6f
ToppCellEpithelial|World / shred on cell class and cell subclass (v4)

FADS3 ATP8A1 SCNN1G CHKA SLC44A3

1.70e-0519274513a3553d9a7c78535679d23d454c63fd08f7d218
ToppCellCOVID-19-Myeloid-DC2|Myeloid / Condition, Lineage and Cell class

TLR10 CD1C ATP8B4 SLC35F2 AQP1

1.75e-051937455f3f6db3d3de887d004662d229f42549601efa81
ToppCelldroplet-Bladder-Unstain-18m-Endothelial|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC7A2 KCNJ2 ITGA7 AQP1 SVOPL

1.84e-05195745fbfe4a8ae9775764108b45920eec92003b24fb2e
ToppCelldroplet-Bladder-Unstain-18m-Endothelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC7A2 KCNJ2 ITGA7 AQP1 SVOPL

1.84e-051957452a6056172c41c46acfe0242be22269ef1d07921e
ToppCell(0)_NK_cells-(0)_NK_CD160pos|(0)_NK_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)

SLC44A1 ATP8B4 GYG1 UNC93B1 CHKA

1.84e-051957456cbeceb52bb207f3c074e57b5b3f7cfb24fd5877
ToppCellIPF-Endothelial-VE_Peribronchial|Endothelial / Disease state, Lineage and Cell class

SYNJ2 ASPH UGCG SLC35F2 ATP11C

1.98e-05198745b8bd1ba268480f54451648e01631b615a3401144
ToppCell3'-Child04-06-SmallIntestine-Epithelial-epithelial_progenitor_cell|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MLXIPL NOX1 KCNJ13 AQP1 SLC44A3

1.98e-05198745e8bfae3888b2406b5629b576cb02913b3297337e
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ATP8B4 ATP11B GYG1 ASPH UGCG

2.02e-05199745b7af2b4fe6866cc8c78cf0f78390aab1b1b389ba
ToppCelldistal-Hematologic-Plasmacytoid_Dendritic-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TLR10 SLC32A1 ADAM20 UGCG SIDT1

2.07e-05200745ef42753c9fbe3770e3f415cd7ab412654d359edb
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SYNJ2 SIDT1 ADGRV1 CHKA SLC44A3

2.07e-052007450eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCellileum-Epithelial_Stem_Cells|ileum / shred on tissue and cell subclass

SRD5A3 KCNJ13 SYP UTP20

5.80e-05126744a8ed48cbd1e207fd1aaad454fda9f329eb22aa83
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4/8-lo-Trm_Tgd|lymph-node_spleen / Manually curated celltypes from each tissue

ATP8B4 KCNJ14 SYP CHKA

1.29e-04155744b0e456c4915076e1d38282e116a6eb3230ae80dc
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(NPW+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC7A2 SYP RXFP4 ADGRV1

1.29e-04155744498e52e2364ff44d3c0c707ba22468217031f5bd
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

TLR10 POLE UGCG SIDT1

1.32e-0415674419472ef1642c2ad333aa3ce3675a25c6ab1d4556
ToppCellCOVID-19-Myeloid-Dendritic_cells|COVID-19 / group, cell type (main and fine annotations)

TLR10 CD1C ATP8B4 TLR1

1.32e-04156744a07a9096799e4ba663841c70035b4b32c1fda4f9
ToppCellControl-Myeloid-DC_Langerhans|Control / Disease state, Lineage and Cell class

TLR10 CD1C ATP8B4 FGF19

1.32e-0415674458f371722d21005a9be2e67844ec2e5fec6e31e5
ToppCellControl-Myeloid-DC_Langerhans|World / Disease state, Lineage and Cell class

TLR10 CD1C ATP8B4 FGF19

1.39e-04158744ec425ec7b8e3c527b4bbe57908d84528b9747796
ToppCellControl-Myeloid-DC_Langerhans|Myeloid / Disease state, Lineage and Cell class

TLR10 CD1C ATP8B4 FGF19

1.46e-04160744174775fb5cc7b478c6cd04f7c565738648ec2fc3
ToppCellLAM-Lymphoid-pDC|LAM / Condition, Lineage and Cell class

TLR10 SLC32A1 UGCG SIDT1

1.50e-04161744bb5b44713e4da4406cdaa79dcf2aa9f97e3cf75a
ToppCellMultiple_Sclerosis-Lymphocyte-T_NK-NK_CD56bright|Multiple_Sclerosis / Disease, Lineage and Cell Type

SLC44A1 ATP8B4 AQP1 SVOPL

1.57e-0416374482c4b25f05bd404fdee9aa90f23efd6dffc04e7b
ToppCellNS-moderate-d_16-33-Myeloid-Mast_cell|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SLC35F2 ITGA7 AQP1 SVOPL

1.61e-0416474435c673380f75cb4bfe080089bc723c4373bcc7a5
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAJC13 ATP8B4 ATP11B TLR1

1.61e-0416474454f8f11d2fa899005530c08e7a1ee728c7b0799c
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_5|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SLC32A1 CD1C ATP8B4 GPR158

1.61e-041647443a4ecc632be003d09b765c992804134348d2278b
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_5|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SLC32A1 CD1C ATP8B4 GPR158

1.61e-041647444b10b78d4d76023c3c5bcd427757218fdd5465ca
ToppCellTCGA-Colorectal|World / Sample_Type by Project: Shred V9

TMEM150B VIL1 NOX1 RXFP4

1.68e-04166744c018cd8c7a82251c67e3dc812d4d21e527a43456
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VIL1 MLXIPL SLC44A1 FGF19

1.72e-04167744720dc5855c856b478b5ca90156b30bfcc5518d60
ToppCellPCW_05-06-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_macrophage_(16)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

TLR10 CD1C ATP8B4 TLR1

1.72e-041677440d187e40a5b96b595761f7aea1a0835462d8270f
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l5|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CHST10 SIDT1 SCNN1G SLC35F2

1.80e-041697441de3ae36d3b60e961bfd9f7bdc37867b82a0417f
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.4.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP8B4 ATP11B GYG1 UGCG

1.84e-04170744cf22a843ae2d9cd6693507fed2b7c6a45abea10e
ToppCell3'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VIL1 NOX1 TMEM45B SLC44A3

1.88e-04171744f2b31c97bbcc5164fc279ed0362007878887ad5e
ToppCellmetastatic_Brain-Myeloid_cells-CD207+CD1a+_LCs|Myeloid_cells / Location, Cell class and cell subclass

TLR10 CD1C SCNN1G UQCC1

1.93e-0417274438d17e769fe8eac8b57b820490d4ddd969243ee7
ToppCell3'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-TA|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VIL1 NOX1 TMEM45B SLC44A3

1.97e-04173744021457c7bdb55de7351e43322d360e8fd7061658
ToppCellfacs-Aorta-Heart-24m-Epithelial|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VIL1 NOX1 TMEM45B TLR1

1.97e-0417374486aa15cf5c450465290de1c3dd9ff9d355d9cbee
ToppCellfacs-Aorta-Heart-24m-Epithelial-epithelial_cell|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VIL1 NOX1 TMEM45B TLR1

1.97e-041737442216e36c77cb3b531508f897c1e7e01b94037d5e
ToppCellwk_15-18-Hematologic-Myeloid-pDC|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SLC32A1 UGCG SIDT1 UNC93B1

1.97e-04173744b571970e3ba88afc07041c5692ccfd85fc39e796
ToppCellP07-Epithelial|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ATP8A1 KCNJ13 SCNN1G SLC44A3

1.97e-041737448b10087a917b825809d35a2b2b349c73a2782472
ToppCellfacs-Aorta-Heart-24m-Epithelial-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VIL1 NOX1 TMEM45B TLR1

1.97e-04173744a3a09fe5cdb9e91e0880e247bf8d974fe29c6fa8
ToppCellFetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SLC7A2 FADS3 UGCG ITGA7

2.01e-04174744015d3742d3d79a57413a333f00ef2d380a9848dd
ToppCellP07-Epithelial-alveolar_epithelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ATP8A1 KCNJ13 SCNN1G SLC44A3

2.01e-041747442739de68e0266054694f99807cfb1f07b6bbb371
ToppCell3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MLXIPL SLC7A2 RXFP4 ADGRV1

2.01e-04174744a62531ebf16b32b249168dca11b870f63a8aa81c
ToppCellIIF-Myeloid-pDC|IIF / Disease, Lineage and Cell Type

SLC32A1 UGCG SIDT1 UNC93B1

2.06e-0417574435cfb7d0b88678ff5b83ad6e19dbc15a908a3fcc
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SIDT1 SCNN1G ADAM29 ADGRV1

2.10e-041767443bbac5c2397535631fce8fa98f6ddb4fe0260351
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TLR10 SLC32A1 UGCG SIDT1

2.15e-041777448887ff6341eb070bdaa890cc2cd7745f0cf1b0af
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TLR10 SLC32A1 UGCG SIDT1

2.15e-04177744507f06d31ab773099c9431b6f433899dc97b5566
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TLR10 SLC32A1 UGCG SIDT1

2.24e-04179744c9f45cfea0ceb0cdc31bcfd123aeab69aeb35c35
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ATP8A1 ASPH ADGRV1 CHKA

2.24e-04179744fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-pDC|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC32A1 UGCG SIDT1 UNC93B1

2.24e-04179744bbd4f8e988ef3f343aaedbc992b70f2bb6aff5f6
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TLR10 SLC32A1 UGCG SIDT1

2.24e-041797444808469096cd6bec2bdfcf4fc55aa324757600c3
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TLR10 SLC32A1 UGCG SIDT1

2.24e-041797444d55718c6afd8a038d93cc77b9b08171dab9976f
ToppCell18-Airway-Immune-Hematopoietic,_B_Cells|Airway / Age, Tissue, Lineage and Cell class

TLR10 CD1C SIDT1 SVOPL

2.29e-04180744200cecbd8c12a4ec334583fdd5057397504de71e
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

SLC7A2 ATP8A1 ASPH ADGRV1

2.29e-04180744198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCellfacs-Large_Intestine-Proximal-18m-Epithelial-epithelial_cell_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC32A1 MLXIPL POLE AQP1

2.34e-041817449fce5eee75684a7ecac6996e26e9215bc95098b2
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-5|TCGA-Colorectal / Sample_Type by Project: Shred V9

ATP8A1 SRD5A3 ACBD5 SIDT1

2.34e-041817448fcc9e77fee7c248df26b6c59b10e672242e2084
ToppCellP15-Epithelial-alveolar_epithelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FADS3 KCNJ13 SCNN1G SLC44A3

2.34e-041817447033be0ba90556f7e5f7c0d4a9f7644afcb22c9b
ToppCellwk_20-22-Hematologic-Myeloid-pDC|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

SLC32A1 UGCG SIDT1 UNC93B1

2.34e-0418174460607c5ff6d5b1cb416adc034491dca31c41e988
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FADS3 ATP8A1 SCNN1G CHKA

2.34e-04181744b45b11428d13950369347e051d4d517efb2bd4fd
ToppCellfacs-Large_Intestine-Proximal-18m-Epithelial-Lgr5-_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC32A1 MLXIPL POLE AQP1

2.34e-04181744ad97e802e934738ddece675232a72308db2da256
ToppCellCOPD-Myeloid-DC_Mature|World / Disease state, Lineage and Cell class

ATP8A1 UGCG ATP11C CHKA

2.34e-04181744675603a401d92cf9fdcd44e211ec899fa86a0d49
ToppCelltumor_Lung-Myeloid_cells-pDCs|tumor_Lung / Location, Cell class and cell subclass

SLC32A1 UGCG SIDT1 UNC93B1

2.34e-04181744c864ffeb9234b8c29754afc91c85a972889617f4
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MLXIPL SLC7A2 SYP RXFP4

2.39e-041827440e589bf97d51b4b2f723f8c45853ad81b7ce8778
ToppCellIPF-Myeloid-DC_Langerhans|World / Disease state, Lineage and Cell class

TLR10 CD1C ATP8B4 CHKA

2.39e-041827440e8cfbd8ea196f27a227dbb4d2eb93bc48d27922
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TLR10 CD1C ATP8B4 TLR1

2.44e-04183744a97f052950429245c3231464271e1ba539863bba
ToppCellCOVID-19-APC-like-Dendritic_cells|COVID-19 / group, cell type (main and fine annotations)

TLR10 CD1C ATP8B4 TLR1

2.44e-04183744703364836b42aa6ac6c68b42b700ac23c4a1afc7
ToppCellControl-Epithelial_cells-Airway_mucous|Control / group, cell type (main and fine annotations)

VIL1 NOX1 TMEM45B ASPH

2.44e-0418374415d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SLC32A1 ASPH UGCG UNC93B1

2.44e-041837443b123571e10c132227aff65648b4b3c6acb4bd00
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SLC32A1 ASPH UGCG UNC93B1

2.44e-04183744df6fd0927b6e4cf9a1583969a68096e4bccfbace
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FADS3 ATP8A1 SCNN1G CHKA

2.49e-0418474442ce855b4f8475a8298192feec785bdc69bc5bb0
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC32A1 SLC7A2 SCNN1G ATP11C

2.49e-04184744e2de27cee3ea80f9b7a9a7884ceceeaa67b3214a
ToppCellmyeloid-Dendritic_cell-Plasmacytoid_dendritic_cell|World / Lineage, cell class and subclass

SLC32A1 ASPH UGCG UNC93B1

2.49e-0418474411619778bc773ecd1a9867330be04deaf324f31e
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-B_cells-FCRL4+_Memory_B|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TLR10 CD1C FADS3 UNC93B1

2.49e-0418474495cf125127658c4c04445c61809d1aed21ee1f83
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_2|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TLR10 CD1C ATP8B4 SLC35F2

2.49e-041847440a26bcc6610f756939e32a4d6dfeebcbf3a1db86
ToppCellIPF-Myeloid-Mast|World / Disease state, Lineage and Cell class

SLC44A1 ATP8B4 SYNJ2 SVOPL

2.49e-041847447aefa182acad5a53c730945fec85329d7168606a
ToppCellIPF-Myeloid-Mast|IPF / Disease state, Lineage and Cell class

SLC44A1 ATP8B4 SYNJ2 SVOPL

2.49e-04184744c3baf21f10b45cf91ac99997a59f353bcf3de8b7
ToppCellIPF-Myeloid-DC_Langerhans|IPF / Disease state, Lineage and Cell class

TLR10 CD1C ATP8B4 CHKA

2.54e-04185744f8ee3cb2aa9ec70f9ce8797be2b155da27ef6464
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ATP8A1 ASPH ADGRV1 SLC44A3

2.54e-041857440d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_2|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TLR10 CD1C ATP8B4 SLC35F2

2.54e-04185744fec16a5e527fdef32d25957451b6e8ee9796cafd
ToppCellPND01-03-samps-Epithelial|PND01-03-samps / Age Group, Lineage, Cell class and subclass

ATP8A1 SCNN1G CHKA SLC44A3

2.54e-041857442b854df79cfe2cb4d2f9c2938a066e0aa3649325
ToppCell3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SYNJ2 KCNJ2 SIDT1 AQP1

2.54e-04185744602536a3308a848f106adcb0a83530997440c8f4
ToppCelldroplet-Bladder-nan-24m-Endothelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNJ2 ITGA7 ACKR4 AQP1

2.54e-0418574490caab8d9361a541c5d5121c97c3f1cdffeeae4a
ToppCellPCW_05-06-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_migrating_dendritic_(5)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

TLR10 CD1C ATP8B4 TLR1

2.60e-0418674473185d48c874e18dd2e2eeea67c32d3182ea88a5
ToppCellPCW_05-06-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor3_(13)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

TLR10 CD1C ATP8B4 TLR1

2.60e-041867446575ec6a626cdea169ffd185d47828dfaa29475d
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ATP8A1 ASPH SCNN1G CHKA

2.60e-041867444e94158db52df41d71e67b02b9895a358eebee0f
ToppCellfacs-BAT-Fat-24m-Epithelial-Epcam+|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM45B SLC35F2 ACKR4 SLC44A3

2.60e-04186744b18d7398279a2d42414318aeb70514fd402f5a0a
ToppCellPCW_05-06-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_dendritic_(11)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

TLR10 CD1C ATP8B4 TLR1

2.60e-04186744fc6e591089c87a66653c8e552be9c0fe0c82ecd5
ToppCellcellseq-Immune-Immune_Myeloid-Myeloid_Dendritic-pDC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TLR10 SLC32A1 UGCG SIDT1

2.60e-04186744d23c3318937492d7d665bec14253124c49181b5a
DrugLoracarbef [121961-22-6]; Up 200; 10.8uM; MCF7; HT_HG-U133A

ABCA2 NOX1 ATP8A1 TLR1 ETNK2 ADAM29 ITGA7 AQP1

2.35e-071987383532_UP
Diseaseanti-Helicobacter pylori serum IgG measurement

TLR10 TLR1

1.76e-053722EFO_0005247
DiseaseHidradenitis suppurativa, familial

PSEN1 PSENEN

1.76e-053722C1840560
Diseasehidradenitis suppurativa (is_implicated_in)

PSEN1 PSENEN

3.51e-054722DOID:2280 (is_implicated_in)
Diseaseearly-onset Parkinson's disease (implicated_via_orthology)

PSEN1 SYNJ2

8.75e-056722DOID:0060894 (implicated_via_orthology)
Diseasebreast cancer, ovarian carcinoma

TLR10 TLR1 ADAM29

1.02e-0437723EFO_0001075, MONDO_0007254
Diseasetraumatic brain injury (biomarker_via_orthology)

NOX1 CAPN1

1.57e-0324722DOID:0081292 (biomarker_via_orthology)
DiseaseCardiac Arrhythmia

KCNJ2 GYG1

1.70e-0325722C0003811
Diseaseglutamine measurement

MLXIPL SLC7A2 UQCC1

1.74e-0397723EFO_0009768
DiseaseL-arginine measurement

VIL1 SLC7A2

1.98e-0327722EFO_0006524
DiseaseDevelopmental Academic Disorder

PSEN1 SYP

2.28e-0329722C1330966
DiseaseLearning Disorders

PSEN1 SYP

2.28e-0329722C0023186
DiseaseLearning Disturbance

PSEN1 SYP

2.28e-0329722C0751263
DiseaseAdult Learning Disorders

PSEN1 SYP

2.28e-0329722C0751262
DiseaseLearning Disabilities

PSEN1 SYP

2.28e-0329722C0751265

Protein segments in the cluster

PeptideGeneStartEntry
FVLWAPAILFWQFVV

CHRM4

161

P08173
VGWWIHFRIVEIVVV

ADAM29

191

Q9UKF5
GWWTHQRFVELVVVV

ADAM20

201

O43506
GVLTFAIIWPFIAQW

ACBD5

506

Q5T8D3
LFALISVTWLWGGLH

ADGRV1

6111

Q8WXG9
VITHNFSNHWIFWVG

AQP1

201

P29972
YWTFINHVFIWGSIA

ATP8B4

1016

Q8TF62
IALLGVWTSVAVVWF

ASPH

61

Q12797
TTVLLWAWGLQAFEI

FAM187A

6

A6NFU0
AGIFHFQLWQFGEWV

CAPN1

146

P07384
WAFITGWNLILSYVI

SLC7A2

111

P52569
FSHIAIWGSIALWVV

ATP8A1

1006

Q9Y2Q0
WLFFGCVFWLIALLH

KCNJ2

96

P63252
LFTLPFWAVNAVHGW

ACKR4

91

Q9NPB9
WLCIFIVAFVSHPAW

ANGPTL7

11

O43827
MGNWVVNHWFSVLFL

NOX1

1

Q9Y5S8
VNHWFSVLFLVVWLG

NOX1

6

Q9Y5S8
LAFFQLRKVWGQVWH

IKBKB

421

O14920
AVILLVVFWFLIGWT

GPR158

531

Q5T848
FQISFRQLGWDHWII

BMP15

296

O95972
FALASHFFWALWALI

ETNK2

336

Q9NVF9
VVVHVWILAGLWLAV

FGF19

6

O95750
SASFVVHWLVFAVLW

KCNJ13

61

O60928
VHWLVFAVLWYVLAE

KCNJ13

66

O60928
LGTSQEEWLVWLRFH

POLE

1261

Q07864
AVGFLFWVIVLTSWI

PSENEN

61

Q9NZ42
WLLFGLAFWLIASLH

KCNJ14

101

Q9UNX9
WFLVLARVAWTAGVV

MRGPRG

166

Q86SM5
FIWVIIVSWVLGFLS

OR9A1P

141

Q8NGU1
LASWFIIFWFSLVHI

OR7D4

146

Q8NG98
GFHNLTWWLVVTNVF

SRD5A3

271

Q9H8P0
THPEFLILWWNIFTT

GYG1

241

P46976
LLWNRVQGFWLIHSI

DNASE2B

131

Q8WZ79
WGHHFSMNWIALVVI

CD1C

296

P29017
SHFLWGLWSIVQAKI

CHKA

416

P35790
ADHWAWLLVLSFVFG

GET1

6

O00258
AVHWVAWFITGFVQL

ABCA2

746

Q9BZC7
LIIGWAAHHVFRWDI

UGCG

301

Q16739
DFWLQTHLFQAGILW

DNAJC13

1531

O75165
WYHVVGLIWISEFIL

SLC44A1

386

Q8WWI5
IFFWVLWVAVLLSLG

SLC44A3

341

Q8N4M1
VLHVWGRLWNSTFLE

ITGA7

1016

Q13683
HSRLFWVQIVLWRQG

HELZ2

1261

Q9BYK8
AVRVLESHWFVWITQ

FADS3

326

Q9Y5Q0
WIGFTLTAVALILWQ

SCNN1G

56

P51170
FLCWFPNHVVTLWGV

RXFP4

256

Q8TDU9
IFSWIVSNHFNLWLA

TAS2R13

86

Q9NYV9
VGLLWVILLHWYANV

TAS2R33

56

P0DSN6
VGLLWVILLHWYSNV

TAS2R36

56

P0DTE0
VFGFLNLVLWVGNLW

SYP

206

P08247
HNWVWLTAAQIFGLL

UTP20

2476

O75691
PFTLWHWLGTLFVFI

SLC35B4

291

Q969S0
LFFTGWWIIIDAAVI

TMEM50A

31

O95807
LIWNFGVVGMISIHW

PSEN1

201

P49768
WDDLFLILQFVWHTS

TLR10

256

Q9BXR5
FLAVWAISGVWIVFA

TMEM150B

11

A6NC51
WGNSFFWNQLLHVPL

SYNJ2

156

O15056
HWDWKIALLFVAFAL

SLC35F2

256

Q8IXU6
RTLHNWKFWVFSILI

MLXIPL

761

Q9NP71
QWWHAQGIIGLILFL

SERINC1

311

Q9NRX5
TLQIWVIWLGISFAY

SVOPL

281

Q8N434
TTWNSFIRILQLVWH

TLR1

256

Q15399
WLDLQFGDHIIHWVT

CHST10

251

O43529
WINHLVTWGSIIFYF

ATP11B

1026

Q9Y2G3
WTWINHFVIWGSLAF

ATP11C

1021

Q8NB49
HDWLNIILWIGEFQT

SPG11

891

Q96JI7
IILQGTWFWQIGFVL

TMEM45B

181

Q96B21
LLDVWDQVFFWIGKH

VIL1

651

P09327
GICFNIALWHVWSFF

TMEM128

131

Q5BJH2
FTIYHWWQAVAIFTV

UNC93B1

471

Q9H1C4
VWFWVIFSAIHVLAS

SIDT1

626

Q9NXL6
VSAFFVLNHLWLWAQ

ZNRF4

266

Q8WWF5
FLVVFIAFLWKHWDA

TMCC1

626

O94876
DTFNSWFLITLLHVW

UQCC1

141

Q9NVA1
VVIWALSLALGWEAF

SLC35F6

301

Q8N357
LWRKLLWHQVFFDVA

SLC32A1

481

Q9H598
VAGAHWLVMTFWLVA

XKR5

211

Q6UX68
AVVWGLVLWLFEYHR

PXMP4

161

Q9Y6I8