Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR52E4 PLXNA3 ITGA11 OR51D1 ADGRF3 OR52K2 NRXN1 IL2RB TAS1R3 OR51J1 OR52B6 OR52E8 OR52E6 ADGRB1 OR52E2

4.66e-0813534215GO:0004888
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR52E4 OR51D1 ADGRF3 OR52K2 TAS1R3 OR51J1 OR52B6 OR52E8 OR52E6 ADGRB1 OR52E2

1.46e-068844211GO:0004930
GeneOntologyMolecularFunctionolfactory receptor activity

OR52E4 OR51D1 OR52K2 OR51J1 OR52B6 OR52E8 OR52E6 OR52E2

2.74e-06431428GO:0004984
GeneOntologyMolecularFunctionsphingosine-1-phosphate phosphatase activity

PLPP7 PLPP6

9.01e-057422GO:0042392
GeneOntologyMolecularFunctioncollagen binding

ITGA11 ACHE ADAM9

6.59e-0481423GO:0005518
GeneOntologyMolecularFunctionlipid phosphatase activity

PLPP7 PLPP6

7.22e-0419422GO:0042577
GeneOntologyMolecularFunctionlaminin binding

ACHE ADAM9

2.32e-0334422GO:0043236
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR52E4 OR51D1 OR52K2 SEMA5B TAS1R3 OR51J1 OR52B6 OR52E8 OR52E6 OR52E2

2.45e-075824310GO:0050906
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR52E4 OR51D1 OR52K2 TAS1R3 OR51J1 OR52B6 OR52E8 OR52E6 OR52E2

5.65e-07485439GO:0050907
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR52E4 OR51D1 OR52K2 TAS1R3 OR51J1 OR52B6 OR52E8 OR52E6 OR52E2

1.08e-06524439GO:0009593
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR52E4 OR51D1 OR52K2 TAS1R3 OR51J1 OR52B6 OR52E8 OR52E6 OR52E2

1.53e-06547439GO:0007606
GeneOntologyBiologicalProcessdetection of stimulus

OR52E4 OR51D1 OR52K2 SEMA5B TAS1R3 OR51J1 OR52B6 OR52E8 OR52E6 OR52E2

1.75e-067224310GO:0051606
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR52E4 OR51D1 OR52K2 OR51J1 OR52B6 OR52E8 OR52E6 OR52E2

2.65e-06432438GO:0050911
GeneOntologyBiologicalProcesssensory perception of smell

OR52E4 OR51D1 OR52K2 OR51J1 OR52B6 OR52E8 OR52E6 OR52E2

4.56e-06465438GO:0007608
GeneOntologyBiologicalProcesspositive regulation of syncytium formation by plasma membrane fusion

GDF15 ADAM9 ADGRB1

2.38e-0527433GO:0060143
GeneOntologyBiologicalProcesssensory perception

OR52E4 OR51D1 OR52K2 SEMA5B TAS1R3 OR51J1 OR52B6 OR52E8 OR52E6 OR52E2

5.50e-0510724310GO:0007600
GeneOntologyBiologicalProcessregulation of syncytium formation by plasma membrane fusion

GDF15 ADAM9 ADGRB1

5.74e-0536433GO:0060142
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR52E4 OR51D1 ADGRF3 OR52K2 TAS1R3 OR51J1 OR52B6 OR52E8 OR52E6 ADGRB1 OR52E2

9.98e-0513954311GO:0007186
DomainEamA_dom

SLC35G5 SLC35G6 SLC35G3 SLC35G4

1.97e-0814414IPR000620
DomainEamA

SLC35G5 SLC35G6 SLC35G3 SLC35G4

1.97e-0814414PF00892
DomainOlfact_rcpt

OR52E4 OR51D1 OR52K2 OR52B6 OR52E8 OR52E6 OR52E2

2.10e-05393417IPR000725
DomainGPCR_Rhodpsn_7TM

OR52E4 OR51D1 OR52K2 OR52B6 OR52E8 OR52E6 OR52E2

5.75e-04670417IPR017452
Domain7tm_1

OR52E4 OR51D1 OR52K2 OR52B6 OR52E8 OR52E6 OR52E2

6.12e-04677417PF00001
DomainG_PROTEIN_RECEP_F1_1

OR52E4 OR51D1 OR52K2 OR52B6 OR52E8 OR52E6 OR52E2

6.56e-04685417PS00237
DomainG_PROTEIN_RECEP_F1_2

OR52E4 OR51D1 OR52K2 OR52B6 OR52E8 OR52E6 OR52E2

6.91e-04691417PS50262
DomainGPCR_Rhodpsn

OR52E4 OR51D1 OR52K2 OR52B6 OR52E8 OR52E6 OR52E2

6.97e-04692417IPR000276
Domain-

PLPP7 PLPP6

7.04e-04184121.20.144.10
DomainacidPPc

PLPP7 PLPP6

7.04e-0418412SM00014
DomainP_Acid_Pase_2/haloperoxidase

PLPP7 PLPP6

8.71e-0420412IPR000326
DomainPAP2

PLPP7 PLPP6

8.71e-0420412PF01569
DomainHRM

ADGRF3 ADGRB1

1.71e-0328412PF02793
DomainSEMA

PLXNA3 SEMA5B

2.10e-0331412PS51004
DomainSema

PLXNA3 SEMA5B

2.10e-0331412SM00630
DomainSemap_dom

PLXNA3 SEMA5B

2.10e-0331412IPR001627
DomainSema

PLXNA3 SEMA5B

2.10e-0331412PF01403
DomainPlexin_repeat

PLXNA3 SEMA5B

2.24e-0332412IPR002165
DomainPSI

PLXNA3 SEMA5B

2.24e-0332412PF01437
DomainGPS

ADGRF3 ADGRB1

2.52e-0334412SM00303
DomainGPS

ADGRF3 ADGRB1

2.67e-0335412PF01825
DomainGPS

ADGRF3 ADGRB1

2.83e-0336412PS50221
DomainGPS

ADGRF3 ADGRB1

2.98e-0337412IPR000203
DomainG_PROTEIN_RECEP_F2_1

ADGRF3 ADGRB1

3.48e-0340412PS00649
DomainG_PROTEIN_RECEP_F2_3

ADGRF3 ADGRB1

3.48e-0340412PS50227
DomainGPCR_2_extracellular_dom

ADGRF3 ADGRB1

3.48e-0340412IPR001879
DomainPSI

PLXNA3 SEMA5B

4.20e-0344412IPR016201
DomainPSI

PLXNA3 SEMA5B

4.58e-0346412SM00423
DomainG_PROTEIN_RECEP_F2_2

ADGRF3 ADGRB1

5.39e-0350412PS00650
Domain7tm_2

ADGRF3 ADGRB1

5.39e-0350412PF00002
DomainGPCR_2-like

ADGRF3 ADGRB1

7.68e-0360412IPR017981
DomainGPCR_2_secretin-like

ADGRF3 ADGRB1

7.68e-0360412IPR000832
DomainG_PROTEIN_RECEP_F2_4

ADGRF3 ADGRB1

7.93e-0361412PS50261
DomainTSP_1

SEMA5B ADGRB1

8.44e-0363412PF00090
DomainTSP1

SEMA5B ADGRB1

8.96e-0365412SM00209
DomainTSP1_rpt

SEMA5B ADGRB1

8.96e-0365412IPR000884
DomainTSP1

SEMA5B ADGRB1

8.96e-0365412PS50092
DomainMFS

MFSD10 SLC22A12

1.24e-0277412IPR011701
DomainMFS_1

MFSD10 SLC22A12

1.24e-0277412PF07690
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR52E4 OR51D1 OR52K2 OR51J1 OR52B6 OR52E8 OR52E6 OR52E2

5.06e-06417348M4072
PathwayREACTOME_SENSORY_PERCEPTION

OR52E4 OR51D1 OR52K2 TAS1R3 OR51J1 OR52B6 OR52E8 OR52E6 OR52E2

1.39e-05636349M41834
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR52E4 OR51D1 OR52K2 OR52B6 OR52E8 OR52E6 OR52E2

3.26e-05389347M14091
Pubmed

RT-PCR of fatty acid elongases.

SLC35G5 SLC35G6 SLC35G3 SLC35G4

2.02e-1244349056918
Pubmed

Emergence of primate genes by retrotransposon-mediated sequence transduction.

SLC35G5 SLC35G6 SLC35G3 SLC35G4

2.02e-12443417101974
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR52E4 OR51D1 OR52K2 OR51J1 OR52E8 OR52E2

3.75e-0634043611875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR52E4 OR51D1 OR52K2 OR51J1 OR52E8 OR52E2

3.75e-0634043611802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR52E4 OR51D1 OR52K2 OR51J1 OR52E8 OR52E2

3.95e-0634343632295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR52E4 OR51D1 OR52K2 OR51J1 OR52E8 OR52E2

4.15e-0634643614611657
Pubmed

The human olfactory receptor gene family.

OR52E4 OR51D1 OR52K2 OR52B6 OR52E8 OR52E6 OR52E2

4.21e-0654143714983052
Pubmed

Two novel genes, Gpr113, which encodes a family 2 G-protein-coupled receptor, and Trcg1, are selectively expressed in taste receptor cells.

ADGRF3 TAS1R3

4.48e-06343215780750
Pubmed

Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells.

PLXNA3 SEMA5B

1.49e-05543225313870
Pubmed

Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration.

NRXN1 ACHE

1.49e-0554329223334
Pubmed

Semaphorin-5B Controls Spiral Ganglion Neuron Branch Refinement during Development.

PLXNA3 SEMA5B

8.15e-051143231209173
Pubmed

Overexpression of integrin α11 induces cardiac fibrosis in mice.

ITGA11 GDF15

1.15e-041343228771943
Pubmed

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.

SLC35G5 IRAK3 SLC35G6 SLC35G3 SLC35G4 ADGRB1

1.72e-0467443637196079
Pubmed

Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function.

PLXNA3 SEMA5B

3.09e-042143221835343
Pubmed

Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.

PLXNA3 SEMA5B

5.53e-042843218617019
Pubmed

The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.

ADGRF3 ADGRB1

5.93e-042943215203201
Pubmed

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.

ADGRF3 ADGRB1

7.69e-043343225713288
Cytoband11p15.4

OR52E4 OR51D1 OR52K2 OR51J1 OR52B6 OR52E8 OR52E6 OR52E2

1.43e-1120043811p15.4
CytobandEnsembl 112 genes in cytogenetic band chr11p15

OR52E4 OR51D1 OR52K2 OR51J1 OR52B6 OR52E8 OR52E6 OR52E2

4.91e-08564438chr11p15
Cytoband15q23

ITGA11 NOX5

7.91e-044443215q23
CytobandEnsembl 112 genes in cytogenetic band chr15q23

ITGA11 NOX5

1.88e-0368432chr15q23
GeneFamilyOlfactory receptors, family 52

OR52E4 OR52K2 OR52B6 OR52E8 OR52E6 OR52E2

1.63e-1049306165
GeneFamilyPhospholipid phosphatases

PLPP7 PLPP6

5.56e-0573021067
GeneFamilySolute carriers

SLC35G5 SLC35G6 SLC35G3 SLC22A12 SLC35G4

4.41e-04395305752
GeneFamilyOlfactory receptors, family 51

OR51D1 OR51J1

2.41e-0344302164
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RARRES2 NRXN1 ACHE GDF15

1.13e-05144434121853910eeea1ea0642b3cc99f9200015480368
ToppCellLPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_3|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLXNA3 SEL1L2 SEMA5B TAS1R3

1.19e-051464342ac9b487a7991fdc15444aeb93533030e09825bb
ToppCellE18.5-samps-Mesenchymal-Pericyte-pericyte_D|E18.5-samps / Age Group, Lineage, Cell class and subclass

PLPP7 ITGA11 LAT2 GDF15

1.29e-05149434dcf68eb25733b5db2893728fe4dca5c7267eb58c
ToppCellLPS-antiTNF-Endothelial-Mes-Like-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLPP7 SEL1L2 RARRES2 PLPP6

1.97e-051664343b750d4023a0a09d86113aae5a97d84391f7b482
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RARRES2 NRXN1 TMEM26 SEMA5B

2.16e-051704341f994b690e881106a5d54b3080ccce6260bc3ac5
ToppCellfacs-Liver-Hepatocytes-24m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AQP8 GDF15 SLC66A1 ADAM9

2.89e-05183434d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RARRES2 NRXN1 TMEM26 SEMA5B

3.34e-05190434106862ef44fcaa0971c3ba0147d13eb08015ca77
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RARRES2 NRXN1 TMEM26 SEMA5B

3.48e-05192434430ef714bf2544d32f3fd96a55af010f79aa9be0
ToppCellP15-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RARRES2 TMEM26 SEMA5B GDF15

3.48e-05192434a476895b7b252c388d6346eacbc72f0115b1443e
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RARRES2 NRXN1 TMEM26 SEMA5B

3.63e-051944346a4e7f1bf67bad94cd8c472e7c66798b0c25ba01
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RARRES2 NRXN1 TMEM26 SEMA5B

3.70e-051954346e875c83f838241b5fcaf4a3249b1408d74521dc
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

AQP8 RARRES2 NRXN1 ADAM9

3.93e-051984340c4d2c68a42f8a9e964e2dd28092fe75f5216834
ToppCell343B-Epithelial_cells-Epithelial-A_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SLC35G5 ITGA11 SLC35G6

4.44e-057143300ca08c442de977f909f1691c6fa40e7382d02dd
ToppCell343B-Epithelial_cells-Epithelial-A_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SLC35G5 ITGA11 SLC35G6

4.44e-0571433499262154a694d9f84358de9f5deff0d022c7632
DrugU75412E

IL2RB NOX5

8.37e-058402CID003035460
DrugAC1NUR9D

IL2RB GDF15

8.37e-058402CID005489469
Drugschisantherin A

NOX5 ACHE

1.34e-0410402CID000151529
DrugAldicarb

NRXN1 ACHE

1.96e-0412402ctd:D000448
Drugthiadiazolidinone

ACHE GYS1

2.70e-0414402CID000443041
Drugsquamosamide

NOX5 ACHE

3.11e-0415402CID005321487
DrugFicusin

ACHE SLC22A12

3.11e-0415402ctd:D005363
Drugbeta-hydroxy simvastatin acid

GPR155 IL2RB GDF15

3.49e-0478403ctd:C483161
DrugAminophylline [317-34-0]; Up 200; 9.6uM; MCF7; HT_HG-U133A

CYP4F12 LAT2 IL2RB NOX5

3.82e-041964043374_UP
DrugAcacetin [480-44-4]; Up 200; 14uM; MCF7; HT_HG-U133A

RARRES2 NRXN1 LAT2 GDF15

3.97e-041984046044_UP
Drug(S)-(-)-Cycloserine [339-72-0]; Up 200; 39.2uM; MCF7; HT_HG-U133A

IRAK3 RARRES2 LAT2 NOX5

3.97e-041984044346_UP
DrugN-methylcarbamate

ACHE GYS1

5.05e-0419402CID000030536
DrugAC1Q6BAJ

NOX5 ACHE

6.19e-0421402CID000125675
Drugractopamine

PLXNA3 SLC22A12

8.80e-0425402CID000056052
DrugAspartame

ACHE TAS1R3

9.52e-0426402ctd:D001218
Drugdimethyl phosphate

ACHE SLC22A12

1.03e-0327402CID000013134
Drugpenciclovir

IRAK3 MFSD10

1.27e-0330402CID000004725
DrugMCC-555

GDF15 GYS1

1.36e-0331402CID000204109
DrugAP2PL

NOX5 GYS1

1.36e-0331402CID000121867
DrugWater

AQP8 ACHE

1.36e-0331402ctd:D014867
DrugN-acetylhexosamine

SLC35G5 ITGA11 NRXN1 IL2RB ACHE

1.36e-03472405CID000000899
Drugirbesartan

RARRES2 NOX5 GDF15

1.44e-03127403CID000003749
DrugCP 31398

IL2RB GDF15

1.44e-0332402ctd:C402665
Diseasemyasthenia gravis (is_implicated_in)

IL2RB ACHE

4.74e-058392DOID:437 (is_implicated_in)
DiseaseDrug-induced agranulocytosis

AQP8 TMEM26

2.02e-0416392HP_0012235
Diseasesevere acute respiratory syndrome, COVID-19

ADGRF3 NRXN1 SEMA5B GDF15

2.81e-03447394EFO_0000694, MONDO_0100096
Diseasebehavioural disinhibition measurement

SEL1L2 IL2RB

4.44e-0375392EFO_0006946

Protein segments in the cluster

PeptideGeneStartEntry
PLLLLLLWLLGGGVG

ACHE

16

P22303
LILTPIFGLTWGLGL

ADGRF3

976

Q8IZF5
LGWGLPALVVAISVG

ADGRB1

1056

O14514
WLGPLLAGLLVGLLI

AQP8

231

O94778
HLLVPILLLIGWIVG

STRIT1

11

P0DN84
IPLALWLGAVGVGVA

RARRES2

6

Q99969
ELLLTTRPGIGWVHG

NOX5

351

Q96PH1
LLIGWGRSLPVLGLG

MFSD10

351

Q14728
LLGIPGLETLHIWIG

OR52E2

16

Q8NGJ4
LLGIPGLDTLHIWIS

OR52E4

16

Q8NGH9
PFWAVILIGLAGLLG

MUC16

14451

Q8WXI7
IVPLTLSGLLGVAWG

NRXN1

36

P58400
LGPGNLGGLLHWERL

NCKAP5L

246

Q9HCH0
VGIIIISGWGIPALL

GPR155

481

Q7Z3F1
ISGWGIPALLVGVLL

GPR155

486

Q7Z3F1
HHLPWLVGSLGVLLL

SLC66A1

251

Q6ZP29
VLVGGLEFWLGTLHI

PLXNA3

1196

P51805
LVGIPGLGPTIHFWL

OR51D1

26

Q8NGF3
ILVGIPGLESEHLWI

OR51J1

16

Q9H342
GIPGLEQLHIWLSIP

OR52B6

36

Q8NGF0
LLGIPGLEDVHIWIG

OR52E6

16

Q96RD3
WLPRLHALVVGPGLG

NAXD

141

Q8IW45
LVLLVLSWLPHGGAL

GDF15

16

Q99988
PIWIIVGSTLGGLLL

ITGA11

1141

Q9UKX5
PLPWHIRIGILIGIS

IRAK3

261

Q9Y616
LDTLGLRGPLGLWLH

C6orf47

206

O95873
WGHLGLITPTEEGLK

CYP4F12

61

Q9HCS2
LGKDTIPWLGHLLVG

IL2RB

236

P14784
WLLLLGLVGPVLGAA

ADAM9

16

Q13443
WLIEGGPLVVLLDVG

GYS1

106

P13807
ILGPLVRLLGVHGPW

SLC22A12

481

Q96S37
VRLLGVHGPWLPLLV

SLC22A12

486

Q96S37
LGIPGLEDVHIWIGV

OR52E8

21

Q6IFG1
LVGIPGLEHLHIWIS

OR52K2

16

Q8NGK3
ELLWPGAALLVLLGV

LAT2

6

Q9GZY6
ILGLIIILGPGLWTL

SLC35G5

166

Q96KT7
ILGLIIIVGPGLWTL

SLC35G3

166

Q8N808
LIIGRWLLPIGGGIT

TMEM26

156

Q6ZUK4
HWDLFVIGLIVPGLI

SEL1L2

666

Q5TEA6
ILGLIIIVGPGLWTL

SLC35G4

166

P0C7Q5
VLGLSLWALLHPGTG

TAS1R3

6

Q7RTX0
TVGGWLLSLVRGLLP

SEMA5B

31

Q9P283
ILGLIIIVGPGLWTL

SLC35G6

166

P0C7Q6
LLEISGHGIPWLLGT

PLPP6

136

Q8IY26
HGIPWIGGTILCLVK

PLPP7

121

Q8NBV4