Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionGTPase activator activity

ARHGAP6 RIN3 RAP1GAP ARAP3 RAPGEF2

1.36e-04279365GO:0005096
GeneOntologyMolecularFunctionsmall GTPase binding

TRIOBP RIN3 RAP1GAP DIAPH3 RPH3A

2.61e-04321365GO:0031267
GeneOntologyMolecularFunctionGTPase binding

TRIOBP RIN3 RAP1GAP DIAPH3 RPH3A

4.41e-04360365GO:0051020
GeneOntologyMolecularFunctionenzyme activator activity

ARHGAP6 RIN3 RAP1GAP ARAP3 RAPGEF2 RING1

1.03e-03656366GO:0008047
GeneOntologyMolecularFunctionGTPase regulator activity

ARHGAP6 RIN3 RAP1GAP ARAP3 RAPGEF2

2.04e-03507365GO:0030695
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

ARHGAP6 RIN3 RAP1GAP ARAP3 RAPGEF2

2.04e-03507365GO:0060589
DomainRA

RIN3 ARAP3 RAPGEF2

4.88e-0537363PS50200
DomainRA_dom

RIN3 ARAP3 RAPGEF2

6.19e-0540363IPR000159
DomainRA

RIN3 RAPGEF2

1.62e-0331362SM00314
Domainzf-C2H2

ZBTB46 ZNF469 BCL11B ZNF335 ZNF516 ZNF697

1.92e-03693366PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZBTB46 ZNF469 BCL11B ZNF335 ZNF516 ZNF697

1.94e-03694366IPR013087
DomainRA

ARAP3 RAPGEF2

2.18e-0336362PF00788
DomainZINC_FINGER_C2H2_2

ZBTB46 ZNF469 BCL11B ZNF335 ZNF516 ZNF697

3.36e-03775366PS50157
DomainZINC_FINGER_C2H2_1

ZBTB46 ZNF469 BCL11B ZNF335 ZNF516 ZNF697

3.40e-03777366PS00028
DomainZnf_C2H2-like

ZBTB46 ZNF469 BCL11B ZNF335 ZNF516 ZNF697

3.83e-03796366IPR015880
DomainZnf_C2H2

ZBTB46 ZNF469 BCL11B ZNF335 ZNF516 ZNF697

4.05e-03805366IPR007087
DomainZnF_C2H2

ZBTB46 ZNF469 BCL11B ZNF335 ZNF516 ZNF697

4.13e-03808366SM00355
DomainRhoGAP

ARHGAP6 ARAP3

6.35e-0362362SM00324
DomainRhoGAP

ARHGAP6 ARAP3

6.55e-0363362PF00620
DomainRHOGAP

ARHGAP6 ARAP3

6.76e-0364362PS50238
DomainRhoGAP_dom

ARHGAP6 ARAP3

6.76e-0364362IPR000198
Domain-

ARHGAP6 ARAP3

6.76e-03643621.10.555.10
Domain-

ZBTB46 BCL11B ZNF335 ZNF516 ZNF697

9.28e-036793653.30.160.60
DomainRho_GTPase_activation_prot

ARHGAP6 ARAP3

1.25e-0288362IPR008936
Pubmed

A LewisX glycoprotein screen identifies the low density lipoprotein receptor-related protein 1 (LRP1) as a modulator of oligodendrogenesis in mice.

BCL11B FUT4

6.60e-06437223615909
Pubmed

Fut9 Deficiency Causes Abnormal Neural Development in the Mouse Cerebral Cortex and Retina.

BCL11B FUT4

1.65e-05637235753011
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PFAS RIN3 ARAP3 ZDHHC8 ZNF335 ANO8 ZNF516 BAHCC1

1.72e-05110537835748872
Pubmed

Interaction network of human early embryonic transcription factors.

BCL11B TAF4 ZNF516 BAHCC1 RING1

3.40e-0535137538297188
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

DNAAF2 PRAM1 MYPOP PDCD7 RING1

6.03e-0539637526687479
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TRIOBP BCL11B TAF4 RAPGEF2 RPH3A APC2 ZNF516

6.08e-0596337728671696
Pubmed

A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors.

BCL11B DIAPH3

7.22e-051237222246438
Pubmed

Crucial Role of Rapgef2 and Rapgef6, a Family of Guanine Nucleotide Exchange Factors for Rap1 Small GTPase, in Formation of Apical Surface Adherens Junctions and Neural Progenitor Development in the Mouse Cerebral Cortex.

BCL11B RAPGEF2

8.53e-051337227390776
Pubmed

High-mobility group nucleosomal binding domain 2 protects against microcephaly by maintaining global chromatin accessibility during corticogenesis.

BCL11B FUT4

8.53e-051337231699896
Pubmed

Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo.

BCL11B DIAPH3

9.94e-051437215664173
Pubmed

Rap2A links intestinal cell polarity to brush border formation.

RAP1GAP RAPGEF2

1.15e-041537222797597
Pubmed

SOX5 controls the sequential generation of distinct corticofugal neuron subtypes.

BCL11B DIAPH3

1.15e-041537218215621
Pubmed

Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.

BCL11B APC2

1.15e-041537222573669
Pubmed

Fezl is required for the birth and specification of corticospinal motor neurons.

BCL11B DIAPH3

1.48e-041737216157277
Pubmed

Differential regulation of microtubule severing by APC underlies distinct patterns of projection neuron and interneuron migration.

BCL11B APC2

2.07e-042037225535916
Pubmed

Compensatory Actions of Ldb Adaptor Proteins During Corticospinal Motor Neuron Differentiation.

BCL11B DIAPH3

5.69e-043337226830346
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

PFAS TAF4 PDCD7 ZNF335 ZNF516

7.76e-0468937536543142
Pubmed

Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical Projection Neuron Generation.

BCL11B ZDHHC8

8.80e-044137225452572
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZBTB46 ZNF469 BCL11B ZNF335 ZNF516 ZNF697

4.47e-0471826628
Diseaseresponse to antihypertensive drug

RBMXL2 RAPGEF2

1.09e-0341352EFO_0005405
Diseaseimmunoglobulin isotype switching measurement

RIN3 HVCN1

1.25e-0344352EFO_0010128
Diseasecortical thickness

TRIOBP ZNF469 RIN3 BCL11B DIAPH3 RAB44

1.81e-031113356EFO_0004840
Diseasebasophil measurement

ZNF469 RAB44

2.32e-0360352EFO_0803539
Diseasebasophil count

TRIOBP PRAM1 ZNF469 RIN3

2.48e-03483354EFO_0005090
Diseasecholesterol to total lipids in medium VLDL percentage

PRAM1 ZNF335

2.55e-0363352EFO_0022239
Diseasetriglycerides to total lipids in medium VLDL percentage

PRAM1 ZNF335

2.55e-0363352EFO_0022335
Diseasebrain measurement, neuroimaging measurement

TRIOBP RIN3 BCL11B BAHCC1

3.96e-03550354EFO_0004346, EFO_0004464
DiseaseEczema

ZBTB46 RIN3 BCL11B

5.86e-03310353HP_0000964
Diseasecorneal topography

ZNF469 BCL11B

7.43e-03109352EFO_0004345

Protein segments in the cluster

PeptideGeneStartEntry
PAPRPTGPLPRSDGK

BAHCC1

1496

Q9P281
KAGPSPPRRGRDAPP

ARAP3

691

Q8WWN8
AYAPSRRPDGPGPPD

DUSP8

401

Q13202
GEEAKRPPPRAPGDP

CHRNA2

26

Q15822
PKAPDGPESPEGSPR

BSX

176

Q3C1V8
PPSGPEEPGEKRPKF

DIAPH3

46

Q9NSV4
ERGKRPPPEGEPAAP

ANO8

16

Q9HCE9
PGKSAPPRGSPPRGA

RAB44

736

Q7Z6P3
ARPDGEPKGPLPDFP

DNAAF2

211

Q9NVR5
EPFGGRDSAPRPPPD

FUT4

196

P22083
PAPGPAPRAPLDFRG

HVCN1

76

Q96D96
RPFPGTDAGERPRPP

PDCD7

96

Q8N8D1
PEAGPGADTRKPPRP

LMNTD2

491

Q8IXW0
HGSGRDDKRPPPPYP

ARHGAP6

871

O43182
ARSGGPAPAPRFPLP

FJX1

51

Q86VR8
TRFPPQRPSAGPDPG

GASK1A

31

Q9UFP1
GSTPEDAPAGPPPRK

APC2

2171

O95996
GTEPFPGLFPRKPAP

BCL11B

661

Q9C0K0
GFPPAKRFRPGSGPP

DHX33

6

Q9H6R0
APDSAPGPAPKRPRG

RING1

191

Q06587
GKPAEPPRDRAPGFP

RIN3

191

Q8TB24
PPAAKLRPPPEGSAG

TAF4

121

O00268
RPGPGPAGRFPDQKP

RPH3A

301

Q9Y2J0
PARPPSEPKSGAFPR

PRAM1

176

Q96QH2
GPPLPDPAVFRKGPE

RAP1GAP

346

P47736
KPAFESSRRGPPPPR

RBMXL2

86

O75526
DPGLRPGPKRGPSPS

TRIOBP

76

Q9H2D6
RKEGRYREPPPTPPG

RAPGEF2

1391

Q9Y4G8
PPQGDKSRSPRSPPG

PRB1

81

P04280
PPRKRASGPGDPAPA

ZNF516

476

Q92618
PPTFPKASVPREPGG

PFAS

1046

O15067
FGRAPSAPDKPPRTP

ZNF469

3806

Q96JG9
FGAGPPLARPPREKP

ZNF697

246

Q5TEC3
PGATGDPPRPLPRSF

ZDHHC8

511

Q9ULC8
GLPRDGPEPPSPAKT

ZNF335

966

Q9H4Z2
SPRPRSPPGGPDKDF

ZBTB46

571

Q86UZ6
EGGCPRPKERESPPP

MYPOP

191

Q86VE0