Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbenzoate-CoA ligase activity

ACSM2A ACSM2B

7.13e-053982GO:0018858
GeneOntologyMolecularFunctiondecanoate-CoA ligase activity

ACSM2A ACSM2B

1.42e-044982GO:0102391
GeneOntologyMolecularFunctionNADPH-hemoprotein reductase activity

MTRR CYB5R4

2.36e-045982GO:0003958
GeneOntologyCellularComponentstereocilium tip

CDH23 PKHD1L1 STRCP1

1.44e-0422983GO:0032426
GeneOntologyCellularComponentendoplasmic reticulum lumen

PCSK5 COL8A1 F8 F9 MEN1 ENAM QSOX1 CDH2

1.69e-04332988GO:0005788
HumanPhenoMelena

CD109 F8 F9 MEN1

1.60e-0524344HP:0002249
DomainPbH1

FBXO11 PKHD1L1

3.71e-046942SM00710
DomainGF_recep_IV

PCSK5 PCSK6

3.71e-046942PF14843
DomainGF_recep_IV

PCSK5 PCSK6

3.71e-046942IPR032778
DomainPeptidase_S8_Asp-AS

PCSK5 PCSK6

3.71e-046942IPR023827
DomainPbH1

FBXO11 PKHD1L1

3.71e-046942IPR006626
DomainP_proprotein

PCSK5 PCSK6

5.18e-047942PF01483
DomainS8_pro-domain

PCSK5 PCSK6

5.18e-047942IPR032815
DomainHematopoietin_rcpt_Gp130_CS

IL12RB2 OSMR

5.18e-047942IPR003529
DomainPrprotnconvertsP

PCSK5 PCSK6

5.18e-047942IPR002884
Domain-

PCSK5 PCSK6

5.18e-0479423.30.70.850
DomainS8_pro-domain

PCSK5 PCSK6

5.18e-047942PF16470
DomainMacrogloblnA2_thiol-ester-bond

CPAMD8 CD109

6.88e-048942IPR019565
DomainHEMATOPO_REC_L_F2

IL12RB2 OSMR

6.88e-048942PS01353
DomainPectin_lyase_fold/virulence

FBXO11 PKHD1L1

6.88e-048942IPR011050
DomainThiol-ester_cl

CPAMD8 CD109

6.88e-048942PF10569
DomainMacrogloblnA2_CS

CPAMD8 CD109

6.88e-048942IPR019742
DomainA2M_N_2

CPAMD8 CD109

6.88e-048942SM01359
Domain-

CPAMD8 CD109

6.88e-0489422.60.40.690
DomainA2M_recep

CPAMD8 CD109

6.88e-048942SM01361
DomainA2M

CPAMD8 CD109

6.88e-048942SM01360
DomainPeptidase_S8_His-AS

PCSK5 PCSK6

8.82e-049942IPR022398
DomainPeptidase_S8_Ser-AS

PCSK5 PCSK6

8.82e-049942IPR023828
DomainA2M

CPAMD8 CD109

1.10e-0310942PF00207
DomainA2M_N_2

CPAMD8 CD109

1.10e-0310942IPR011625
DomainA2M_comp

CPAMD8 CD109

1.10e-0310942IPR011626
DomainA2M_recep

CPAMD8 CD109

1.10e-0310942PF07677
DomainA2M_comp

CPAMD8 CD109

1.10e-0310942PF07678
DomainA2M_N

CPAMD8 CD109

1.10e-0310942PF01835
DomainPeptidase_S8_subtilisin-rel

PCSK5 PCSK6

1.10e-0310942IPR015500
DomainA2M_N

CPAMD8 CD109

1.10e-0310942IPR002890
DomainA-macroglobulin_rcpt-bd

CPAMD8 CD109

1.10e-0310942IPR009048
DomainALPHA_2_MACROGLOBULIN

CPAMD8 CD109

1.10e-0310942PS00477
DomainA2M_N_2

CPAMD8 CD109

1.10e-0310942PF07703
DomainSUBTILASE_ASP

PCSK5 PCSK6

1.10e-0310942PS00136
DomainSUBTILASE_HIS

PCSK5 PCSK6

1.10e-0310942PS00137
DomainSUBTILASE_SER

PCSK5 PCSK6

1.10e-0310942PS00138
DomainMacroglobln_a2

CPAMD8 CD109

1.10e-0310942IPR001599
Domain-

PCSK5 PCSK6

1.34e-03119423.40.50.200
DomainPeptidase_S8/S53_dom

PCSK5 PCSK6

1.34e-0311942IPR000209
DomainPeptidase_S8

PCSK5 PCSK6

1.34e-0311942PF00082
DomainOxRdtase_FAD/NAD-bd

MTRR CYB5R4

1.60e-0312942IPR001433
DomainNAD_binding_1

MTRR CYB5R4

1.60e-0312942PF00175
Domain-

CPAMD8 CD109

1.60e-03129421.50.10.20
DomainIg_E-set

CPAMD8 RBPJL CD109 PKHD1L1

1.88e-03104944IPR014756
DomainPLAC

PCSK5 PCSK6

2.19e-0314942PF08686
DomainGlycoside_hydrolase_SF

GALC MYORG KL

2.41e-0353943IPR017853
DomainPropept_inh

PCSK5 PCSK6

3.24e-0317942IPR009020
DomainAMP-bd_C

ACSM2A ACSM2B

3.24e-0317942IPR025110
DomainAMP-binding_C

ACSM2A ACSM2B

3.24e-0317942PF13193
DomainTerpenoid_cyclase/PrenylTrfase

CPAMD8 CD109

3.64e-0318942IPR008930
DomainFurin_repeat

PCSK5 PCSK6

3.64e-0318942IPR006212
DomainFU

PCSK5 PCSK6

3.64e-0318942SM00261
DomainDH_1

TRIO ARHGEF11 ARHGEF17

3.94e-0363943PS00741
DomainFd_Rdtase_FAD-bd

MTRR CYB5R4

4.05e-0319942IPR017927
DomainPLAC

PCSK5 PCSK6

4.05e-0319942PS50900
DomainFAD_FR

MTRR CYB5R4

4.05e-0319942PS51384
DomainPLAC

PCSK5 PCSK6

4.05e-0319942IPR010909
DomainRiboflavin_synthase-like_b-brl

MTRR CYB5R4

4.05e-0319942IPR017938
DomainRhoGEF

TRIO ARHGEF11 ARHGEF17

4.88e-0368943SM00325
DomainConA-like_dom

PAPPA2 FAT4 BTN2A1 BTNL3 SEL1L3

5.00e-03219945IPR013320
Pubmed

Na+ site in blood coagulation factor IXa: effect on catalysis and factor VIIIa binding.

F8 F9

8.18e-062100215913649
Pubmed

The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population.

ACSM2A ACSM2B

8.18e-062100216521160
Pubmed

Activation of the factor VIIIa-factor IXa enzyme complex of blood coagulation by membranes containing phosphatidyl-L-serine.

F8 F9

8.18e-06210028626656
Pubmed

Recurrent F8 and F9 gene variants result from a founder effect in two large French haemophilia cohorts.

F8 F9

8.18e-062100229656491
Pubmed

In vivo genome editing of the albumin locus as a platform for protein replacement therapy.

F8 F9

8.18e-062100226297739
Pubmed

Factor VIII-driven changes in activated factor IX explored by hydrogen-deuterium exchange mass spectrometry.

F8 F9

8.18e-062100232678887
Pubmed

Development of inhibitors in haemophilia. Ongoing epidemiological study.

F8 F9

8.18e-062100222057218
Pubmed

Novel F8 and F9 gene variants from the PedNet hemophilia registry classified according to ACMG/AMP guidelines.

F8 F9

8.18e-062100232935414
Pubmed

Human coagulation factor VIII domain-specific recombinant polypeptide expression.

F8 F9

8.18e-062100226157780
Pubmed

Structural insights into the interaction of blood coagulation co-factor VIIIa with factor IXa: a computational protein-protein docking and molecular dynamics refinement study.

F8 F9

8.18e-062100225157807
Pubmed

Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases.

PCSK5 PCSK6

8.18e-062100218061232
Pubmed

3-Dimensional structure of membrane-bound coagulation factor VIII: modeling of the factor VIII heterodimer within a 3-dimensional density map derived by electron crystallography.

F8 F9

8.18e-062100211830468
Pubmed

Carrier detection and prenatal diagnosis in families with haemophilia.

F8 F9

8.18e-062100211396323
Pubmed

Next generation FIX muteins with FVIII-independent activity for alternative treatment of hemophilia A.

F8 F9

8.18e-062100225224783
Pubmed

A3 domain region 1803-1818 contributes to the stability of activated factor VIII and includes a binding site for activated factor IX.

F8 F9

8.18e-062100223884417
Pubmed

Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines.

ACSM2A ACSM2B

8.18e-062100219634011
Pubmed

Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease.

PCSK5 PCSK6

8.18e-06210028335106
Pubmed

Molecular models of the procoagulant factor VIIIa-factor IXa complex.

F8 F9

8.18e-062100216102111
Pubmed

Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4.

PCSK5 PCSK6

8.18e-06210028468318
Pubmed

Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B.

ACSM2A ACSM2B

8.18e-062100229948332
Pubmed

Factor VIIIa A2 subunit shows a high affinity interaction with factor IXa: contribution of A2 subunit residues 707-714 to the interaction with factor IXa.

F8 F9

8.18e-062100223580639
Pubmed

Identification of mutations in the F8 and F9 gene in families with haemophilia using targeted high-throughput sequencing.

F8 F9

8.18e-062100227292088
Pubmed

Factor IXa:factor VIIIa interaction. helix 330-338 of factor ixa interacts with residues 558-565 and spatially adjacent regions of the a2 subunit of factor VIIIa.

F8 F9

8.18e-062100211278963
Pubmed

Replacing the factor VIII C1 domain with a second C2 domain reduces factor VIII stability and affinity for factor IXa.

F8 F9

8.18e-062100224030831
Pubmed

X Chromosome inactivation: a modifier of factor VIII and IX plasma levels and bleeding phenotype in Haemophilia carriers.

F8 F9

8.18e-062100233082527
Pubmed

The factor VIIIa C2 domain (residues 2228-2240) interacts with the factor IXa Gla domain in the factor Xase complex.

F8 F9

8.18e-062100219047063
Pubmed

Combined coagulation factor VIII and factor IX deficiency (CDF8F9) in a patient from Lithuania.

F8 F9

8.18e-062100227824213
Pubmed

Heme binds to factor VIII and inhibits its interaction with activated factor IX.

F8 F9

8.18e-062100222471307
Pubmed

[Intragenic polymorphisms of factor VIII and IX genes and their utility in the indirect diagnosis of carriers of Haemophilias A and B].

F8 F9

8.18e-062100221305775
Pubmed

Binding studies of the enzyme (factor IXa) with the cofactor (factor VIIIa) in the assembly of factor-X activating complex on the activated platelet surface.

F8 F9

2.45e-053100214629468
Pubmed

Factor V Leiden improves in vivo hemostasis in murine hemophilia models.

F8 F9

2.45e-053100216359510
Pubmed

N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability.

TRIO CDH2

2.45e-053100230463880
Pubmed

Hemophilia A and B mice, but not VWF-/-mice, display bone defects in congenital development and remodeling after injury.

F8 F9

2.45e-053100231594977
Pubmed

Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases.

PCSK5 PCSK6

2.45e-05310028670066
Pubmed

The life cycle of coagulation factor VIII in view of its structure and function.

F8 F9

2.45e-05310029834200
Pubmed

Kinetics of coagulation factor X activation by platelet-bound factor IXa.

F8 F9

2.45e-05310022110473
Pubmed

Targeting anticoagulant protein S to improve hemostasis in hemophilia.

F8 F9

2.45e-053100229317453
Pubmed

A 6-Mb high-resolution physical and transcription map encompassing the hereditary prostate cancer 1 (HPC1) region.

PDC RNASEL

2.45e-053100210708513
Pubmed

Low density lipoprotein receptor-related protein and factor IXa share structural requirements for binding to the A3 domain of coagulation factor VIII.

F8 F9

2.45e-053100212522143
Pubmed

Maturation of HIV envelope glycoprotein precursors by cellular endoproteases.

PCSK5 PCSK6

2.45e-053100211063880
Pubmed

Application of a molecular diagnostic algorithm for haemophilia A and B using next-generation sequencing of entire F8, F9 and VWF genes.

F8 F9

2.45e-053100227734074
Pubmed

Thrombophilic families with inheritably associated high levels of coagulation factors VIII, IX and XI.

F8 F9

2.45e-053100214521595
Pubmed

Intrinsic pathway of blood coagulation contributes to thrombogenicity of atherosclerotic plaque.

F8 F9

2.45e-053100212036878
Pubmed

CDMP1/GDF5 has specific processing requirements that restrict its action to joint surfaces.

PCSK5 PCSK6

4.89e-054100216829522
Pubmed

Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases.

PCSK5 PCSK6

4.89e-05410028615794
Pubmed

Neurotrophin secretion: current facts and future prospects.

PCSK5 PCSK6

4.89e-054100212787574
Pubmed

Variant mapping and mutation discovery in inbred mice using next-generation sequencing.

PCSK5 CLCN1

4.89e-054100226552429
Pubmed

The proprotein convertases furin and PACE4 play a significant role in tumor progression.

PCSK5 PCSK6

4.89e-054100210900462
Pubmed

Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells.

ACSM2A ACSM2B

4.89e-054100232830538
Pubmed

Retroviral envelope glycoprotein processing: structural investigation of the cleavage site.

PCSK5 PCSK6

4.89e-05410029521771
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

PAPPA2 HGD FAT4 SLC5A10 MAN2A1 F9 IGLV3-21 QSOX1 KL CPNE3 C1R GPRC5B

5.90e-0510701001223533145
Pubmed

Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2.

TRIM42 CDH23 TMEM132B

7.17e-0528100324322204
Pubmed

Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.

PCSK5 PCSK6

8.14e-055100218664504
Pubmed

Processing of prothyrotropin-releasing hormone by the family of prohormone convertases.

PCSK5 PCSK6

8.14e-05510029242664
Pubmed

Proprotein convertase expression and localization in epidermis: evidence for multiple roles and substrates.

PCSK5 PCSK6

8.14e-055100211380615
Pubmed

An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.

CDH23 STRCP1

8.14e-055100224920589
Pubmed

TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.

CD109 MYORG QSOX1 SEL1L3 CDH2

1.15e-04164100532409323
Pubmed

Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines.

PCSK5 PCSK6

1.22e-04610028940009
Pubmed

Murine subtilisin-like proteinase SPC6 is expressed during embryonic implantation, somitogenesis, and skeletal formation.

PCSK5 PCSK6

1.22e-04610029291583
Pubmed

Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV.

CAMK4 DCLK3

1.22e-046100216684769
Pubmed

The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases.

PCSK5 PCSK6

1.22e-046100216135528
Pubmed

Sequence of the human factor VIII-associated gene is conserved in mouse.

F8 F9

1.22e-04610021639415
Pubmed

Comparison of the physical and recombination maps of the mouse X chromosome.

F8 F9

1.70e-04710022571569
Pubmed

Proteolytic processing in the secretory pathway.

PCSK5 PCSK6

1.70e-047100210409610
Pubmed

The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.

PCSK5 PCSK6

1.70e-04710027819324
Pubmed

A survey of neurological mutant mice. II. Lipid composition of myelinated tissue in possible myelin mutants.

GALC CLCN1

1.70e-04710023402356
Pubmed

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.

PCSK5 CPAMD8 TRIM42

1.96e-0439100319010793
Pubmed

TLR9-dependent and independent pathways drive activation of the immune system by Propionibacterium acnes.

IL12RB2 UNC93B1

2.27e-048100222745710
Pubmed

Saturation mutagenesis defines novel mouse models of severe spine deformity.

GALC CLCN1

2.27e-048100234142127
Pubmed

Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human.

PCSK5 PCSK6

2.27e-04810027782070
Pubmed

Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.

CDH23 STRCP1

2.27e-048100221165971
Pubmed

Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.

PCSK5 PCSK6

2.27e-04810029885250
Pubmed

Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals.

PCSK5 PCSK6

2.27e-048100210037747
Pubmed

X-chromosome gene order in different Mus species crosses.

F8 F9

2.27e-04810023416629
Pubmed

The activation and physiological functions of the proprotein convertases.

PCSK5 PCSK6

2.91e-049100218343183
Pubmed

Localization of YAP activity in developing skeletal rudiments is responsive to mechanical stimulation.

COL8A1 FAT4

2.91e-049100231747096
Pubmed

The prohormone theory and the proprotein convertases: it is all about serendipity.

PCSK5 PCSK6

2.91e-049100221805236
Pubmed

The proprotein convertases, 20 years later.

PCSK5 PCSK6

2.91e-049100221805237
Pubmed

The biology and therapeutic targeting of the proprotein convertases.

PCSK5 PCSK6

2.91e-049100222679642
Pubmed

Multilocus molecular mapping of the mouse X chromosome.

F8 F9

2.91e-04910022906327
Pubmed

The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions.

PCSK5 PCSK6

2.91e-049100223775089
Pubmed

SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis.

PCSK5 PCSK6

2.91e-04910028698813
Pubmed

FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development.

FBXO11 CDH2

2.91e-049100225827072
Pubmed

Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group.

COMMD5 PREP

3.63e-0410100219795399
Pubmed

Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.

PCSK5 PCSK6

3.63e-0410100216163737
Pubmed

Linkage of a gene for neural cell adhesion molecule, L1 (CamL1) to the Rsvp region of the mouse X chromosome.

F8 F9

3.63e-041010021964443
Pubmed

Abi1 is essential for the formation and activation of a WAVE2 signalling complex.

NEB NIN

3.63e-0410100215048123
Pubmed

Physical mapping of the loci Gabra3, DXPas8, CamL1, and Rsvp in a region of the mouse X chromosome homologous to human Xq28.

F8 F9

3.63e-041010021684949
Pubmed

Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth.

FAT4 CDH2

4.43e-0411100228239148
Pubmed

Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.

FAT4 FBXO11

4.43e-0411100224349473
Pubmed

Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.

CDH23 STRCP1

4.43e-0411100231776257
Pubmed

The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex.

CDH2 NIN

5.30e-0412100222031545
Pubmed

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

MATK CD109 PKHD1L1 ACKR2 OSMR CDH2 LRIF1 GASK1A GPRC5B

5.75e-04814100923251661
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

FAT4 TRIO NEB ENAM QSOX1 SEPHS2 OSMR

7.17e-04513100725798074
Pubmed

Genetic mapping of the mouse X chromosome in the region homologous to human Xq27-Xq28.

F8 F9

7.28e-041410021674728
Pubmed

Trio controls the mature organization of neuronal clusters in the hindbrain.

TRIO CDH2

8.39e-0415100217898204
Pubmed

Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of SARS-CoV-2.

F8 F9

8.39e-0415100236305765
Pubmed

The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators.

KDM2A CDH2

8.39e-0415100225463925
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

MAN2A1 CD109 F8 QSOX1 C1R

9.01e-04257100516335952
Pubmed

Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.

PCSK5 PCSK6

9.57e-0416100220876279
GeneFamilyProprotein convertase subtilisin/kexin family

PCSK5 PCSK6

4.23e-049632973
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

CPAMD8 CD109

4.23e-0496321234
GeneFamilyButyrophilins|V-set domain containing|C2-set domain containing

BTN2A1 BTNL3

1.22e-0315632458
GeneFamilyCadherin related

FAT4 CDH23

1.57e-031763224
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

TRIO ARHGEF11 ARHGEF17

1.58e-0366633722
GeneFamilyAcyl-CoA synthetase family

ACSM2A ACSM2B

3.68e-032663240
CoexpressionFARMER_BREAST_CANCER_APOCRINE_VS_BASAL

HGD CHST1 QSOX1 SEPHS2 PREP SEL1L3 CDC20 CADPS2 TOP2A

4.46e-06329999M2631
ToppCellnormal_Lung-Endothelial_cells-Lymphatic_ECs|normal_Lung / Location, Cell class and cell subclass

PKHD1L1 F8 PCSK6 ACKR2 KLHL14 ACSM2A GPRC5B ACSM2B

1.17e-0819010082185db6007404a2b22325f91460dd17635be9bba
ToppCellBAL-Severe-Lymphocyte-B-Plasmablast-Plasmablast-Developping_Plasmablast|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PKHD1L1 IGLV3-21 ENAM SEL1L3 KLHL14 CDC20 TOP2A

2.74e-0719310070373984547cefc0cbd77f8e795d508f6fcebc6c8
ToppCellSepsis-ICU-NoSEP-Lymphocyte-B-Plasmablast|ICU-NoSEP / Disease, condition lineage and cell class

IL12RB2 PKHD1L1 KIF24 IGLV3-21 ENAM SEL1L3 KLHL14

3.15e-0719710078f35f9741086a38f0e594dce0547b575946f52bb
ToppCellfacs-Marrow-B-cells-18m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDH23 CHST1 ERMN SEL1L3 KEL CDH2

1.99e-061651006361a605d8f833d9ec54b120480dce397da35f9c3
ToppCell(2)_Plasma_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

PKHD1L1 IGLV3-21 ENAM SEL1L3 ACKR2 KLHL14

2.99e-061771006ed3c936bb69f9bc7291b4f6cde1d204078117c48
ToppCellCOVID-19-kidney-PCT-S1/S2|kidney / Disease (COVID-19 only), tissue and cell type

PCSK5 HGD SLC5A10 ACSM2A CDH2 ACSM2B

3.74e-061841006dc71f22583fc54b89b242cbb602f4bbe86f576ec
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

IP6K3 C10orf90 PRIMA1 ERMN PCSK6 GPRC5B

3.85e-061851006b8d02c9426740ffcb69d2e6f95473b388149d297
ToppCellmild-Lymphocytic-Plasmablast|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PKHD1L1 IGLV3-21 ENAM SEL1L3 KLHL14 CDC20

3.98e-061861006060510c21b1e0889b7a6eeb15821b9e2f03a0f99
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-B_plasma|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PKHD1L1 ENAM SEL1L3 KLHL14 CDC20 CADPS2

4.10e-06187100688d20f150df61ef0e3ee0c3e9895b094920c4b09
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-B_plasma-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PKHD1L1 ENAM SEL1L3 KLHL14 CDC20 CADPS2

4.10e-061871006158c2c003fd225ba61793fb06eece232fb063d05
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_B-plasmablast-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PKHD1L1 ENAM SEL1L3 KLHL14 CDC20 TOP2A

4.23e-061881006ecba5d06cbf3254448255a2aeefffe711f43310e
ToppCell5'-Adult-Distal_Rectal-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CPAMD8 PKHD1L1 F8 ACKR2 GPRC5B CFAP46

4.23e-061881006524a12f433c7b6f33fad36c0716afa06cd3235e9
ToppCell5'-Adult-Distal_Rectal-Endothelial-lymphatic_endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CPAMD8 PKHD1L1 F8 ACKR2 GPRC5B CFAP46

4.23e-061881006d2610b81b3c7f22977b5e2137b1f61410fc4ef16
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_B-plasmablast|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PKHD1L1 ENAM SEL1L3 KLHL14 CDC20 TOP2A

4.23e-0618810068cf135da4d1d2500755d2809d60b41509af9fa8b
ToppCellSevere_COVID-19-B_cell|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

PKHD1L1 IGLV3-21 ENAM SEL1L3 KLHL14 CDC20

4.36e-06189100659ce8f15f413557d2059ee6b53ba5957b864cb8e
ToppCellBAL-Severe-Lymphocyte-B-Plasmablast-Plasmablast-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PKHD1L1 IGLV3-21 ENAM SEL1L3 KLHL14 CDC20

4.36e-061891006b0fcbe13a91a4b8dfa507b7a484f45477ef31609
ToppCellBAL-Severe-Lymphocyte-B-Plasmablast|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PKHD1L1 IGLV3-21 ENAM SEL1L3 KLHL14 CDC20

4.36e-061891006d5d25f4151ea96e2d4b3a0e0910e7ff995eaf752
ToppCellnormal-na-Lymphocytic_B-B_plasma|normal / PBMC cell types (v2) per disease, treatment status, and sex

PKHD1L1 ENAM SEL1L3 CDC20 CADPS2 TOP2A

4.36e-061891006659deb617a560bcde67c75f477d30ce85aaec3c6
ToppCellSevere_COVID-19-B_cell-Plasmablast|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

PKHD1L1 IGLV3-21 ENAM SEL1L3 KLHL14 CDC20

4.36e-061891006d7bfefc8c35374c5288807349a76dbb10e84c52b
ToppCellBAL-Severe-Lymphocyte-B-Plasmablast-Plasmablast|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PKHD1L1 IGLV3-21 ENAM SEL1L3 KLHL14 CDC20

4.36e-0618910060f0607642eecc66222d23afe6d77b6872343cb8e
ToppCellnormal-na-Lymphocytic_B-B_plasma-female|normal / PBMC cell types (v2) per disease, treatment status, and sex

PKHD1L1 ENAM SEL1L3 CDC20 CADPS2 TOP2A

4.36e-06189100667f9a9861d2dcc128b7a69432c6b31da185e2249
ToppCellBAL-Severe-Lymphocyte-B|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PKHD1L1 IGLV3-21 ENAM SEL1L3 KLHL14 CDC20

4.49e-061901006e82fefea5ac03470d10463832d3efd2380895860
ToppCellILEUM-non-inflamed-(7)_Endothelial_cell-(7)_Lymphatics|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PKHD1L1 F8 PCSK6 KLHL14 ACSM2A ACSM2B

4.49e-0619010069ce301841ce9486701fa28eb2a9929e35d476878
ToppCellBAL-Severe-Lymphocyte-B-Plasmablast|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PKHD1L1 IGLV3-21 ENAM SEL1L3 KLHL14 CDC20

4.49e-0619010069560722facaf3516936fcbc2a900a405fd85e5d0
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

IP6K3 C10orf90 PRIMA1 ERMN PCSK6 KEL

4.49e-0619010066b101359f397020a21e2bfd15851cb48e71f4502
ToppCellBAL-Severe-Lymphocyte-B-Plasmablast-Plasmablast|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PKHD1L1 IGLV3-21 ENAM SEL1L3 KLHL14 CDC20

4.49e-0619010067fbaf46bf24d46543047582f0d262f3523e28eb4
ToppCellBAL-Severe-Lymphocyte-B|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PKHD1L1 IGLV3-21 ENAM SEL1L3 KLHL14 CDC20

4.49e-061901006d55b9f9b82bd2b2e1ea2446813fce04f04a1dcdf
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

IP6K3 C10orf90 PRIMA1 ERMN PCSK6 GPRC5B

4.49e-061901006396b7225c2430db3dc55a3d0db70239b71987229
ToppCellCOVID-19_Severe-Plasmablast|World / disease group, cell group and cell class

PKHD1L1 ENAM SEL1L3 KLHL14 CDC20 TOP2A

4.77e-061921006a333053fe2bd206c32790916bfc5fce904ab7f57
ToppCellCOVID-19-Lymphoid-Plasma,_B_cells|COVID-19 / Condition, Lineage and Cell class

PKHD1L1 IGLV3-21 SEL1L3 KLHL14 CDC20 TOP2A

4.92e-061931006bffd97a73365e1dd23ff3b0320b4860f04ec091a
ToppCellcellseq-Endothelial-Endothelial_Lymphatic-LEC-LEC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PKHD1L1 F8 PCSK6 ACKR2 KLHL14 GPRC5B

5.22e-0619510068321531bb976e5005973b82f32177be88113abb3
ToppCellcellseq-Endothelial-Endothelial_Lymphatic|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PKHD1L1 F8 PCSK6 ACKR2 KLHL14 GPRC5B

5.22e-061951006d8f01746c8f92532bd1a5c1b0bbb86208d64c3cd
ToppCellcellseq-Endothelial-Endothelial_Lymphatic-LEC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PKHD1L1 F8 PCSK6 ACKR2 KLHL14 GPRC5B

5.22e-061951006918b68a271a81202778714e10b09c5c724575b73
ToppCelldistal-Endothelial-Lymphatic|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PKHD1L1 ACKR2 KLHL14 ACSM2A GPRC5B ACSM2B

5.37e-0619610063e8a20e1d163dcbd3bbd99fe179d54af02298af0
ToppCelldistal-3-Endothelial-Lymphatic|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PKHD1L1 ACKR2 KLHL14 ACSM2A GPRC5B ACSM2B

5.53e-0619710069ea0e2ed9c3f97591a06e70570640996580417d5
ToppCelldistal-Endothelial-Lymphatic-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PKHD1L1 ACKR2 KLHL14 ACSM2A GPRC5B ACSM2B

5.53e-0619710068f2e19409ebe9a490d5a245fa82c765ed6d77c3e
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_ciliated-Deuterosomal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CFAP43 KIF24 CFAP74 CDC20 TOP2A CFAP46

5.69e-061981006f31790442ef142f1c0c49bf3daf2d0efb193d2c9
ToppCellTracheal-10x5prime-Endothelial-Endothelia_lymphatic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PKHD1L1 F8 ACKR2 KLHL14 ACSM2A ACSM2B

5.69e-06198100605429f18e1d74880c1835568c86177f661b3477a
ToppCellTracheal-10x5prime-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PKHD1L1 F8 ACKR2 KLHL14 ACSM2A ACSM2B

5.69e-061981006306e28d31fd587409a12dcccc6b2abd7dc9c2e0a
ToppCellParenchymal-10x3prime_v2-Endothelial-Endothelia_lymphatic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

PKHD1L1 F8 PCSK6 ACKR2 GPRC5B ACSM2B

6.03e-06200100676e90231aa94afc12e618da8ae314c51644acab4
ToppCellParenchymal-10x3prime_v2-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

PKHD1L1 F8 PCSK6 ACKR2 GPRC5B ACSM2B

6.03e-062001006e3e80cb16e0d2e24efc16b62316a6da91bf81ea5
ToppCellTracheal-10x3prime_v2-Endothelial-Endothelia_lymphatic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

PKHD1L1 F8 ACKR2 KLHL14 ACSM2A ACSM2B

6.03e-062001006b515b2ab0c3f5928dd67f2f227fc932451c272bb
ToppCellTracheal-10x3prime_v2-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

PKHD1L1 F8 ACKR2 KLHL14 ACSM2A ACSM2B

6.03e-06200100635f6c7f2469d12748c27f2a5d4a161ef839b4a07
ToppCellLPS_only-Lymphocytic_NKT-T_cells-iNKT-MAIT|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAM184B IL12RB2 MATK ADAMTSL5 CFAP46

8.95e-06124100505e114fcfe84cfc8d92978a4eda6db4d8a616e0e
ToppCellCOVID-19-Heart-CM_5_(RYR2-)|COVID-19 / Disease (COVID-19 only), tissue and cell type

FAM184B IL12RB2 IP6K3 NEB CLCN1

1.85e-051441005f92e03dd784e31a9e5dbd4f4c3a6517ea19210cf
ToppCellTCGA-Kidney|World / Sample_Type by Project: Shred V9

SLC5A10 ENAM KL ACSM2A ACSM2B

2.32e-051511005e31974c0d0a0c644205a0ee6013ab74a09d8a306
ToppCellCOVID-19-Heart-CM_5_(RYR2-)|Heart / Disease (COVID-19 only), tissue and cell type

FAM184B IL12RB2 IP6K3 NEB CLCN1

2.63e-051551005d7e26696fd9c0a759524f331243db43059b33ed9
ToppCell343B-Lymphocytic-Plasma_cell-|343B / Donor, Lineage, Cell class and subclass (all cells)

SLC5A10 PKHD1L1 IGLV3-21 ENAM KLHL14

2.80e-051571005554ddbaf83f5d6eb4669c673efdbb28fd87e2ba8
ToppCell343B-Lymphocytic-Plasma_cell|343B / Donor, Lineage, Cell class and subclass (all cells)

SLC5A10 PKHD1L1 IGLV3-21 ENAM KLHL14

2.80e-0515710052cb3deb5313ce734710c601935ca318e4179077e
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TDRD5 NEB PKHD1L1 DPPA4 ACSM2B

3.25e-051621005bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IL12RB2 MATK NEB SEPHS2 LRIF1

3.35e-051631005e6213900f56257fe38ac7852351bea0340294be0
ToppCell3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IL12RB2 MATK NEB SEPHS2 LRIF1

3.35e-051631005ed7319185c1ec384444309bb8be95691a0c2091c
ToppCell3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IL12RB2 MATK NEB SEPHS2 LRIF1

3.35e-051631005ef35d7ff09aa364734fea7fdaab6260c0a3fbf09
ToppCell343B-Lymphocytic-Plasma_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SLC5A10 PKHD1L1 IGLV3-21 ENAM CADPS2

3.45e-051641005cf62d34ce9dd220fe61748466c84fd70d9ba697c
ToppCell343B-Lymphocytic-Plasma_cell-|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SLC5A10 PKHD1L1 IGLV3-21 ENAM CADPS2

3.45e-051641005e00549bc8b3a5566f39031f39d7e698b0b107a7f
ToppCell367C-Lymphocytic-CD4_T-cell-Proliferating_T_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

HGD KIF24 KEL CDC20 TOP2A

3.45e-051641005fb18b863152fb3109e2224c791c84c6371680a4e
ToppCellEndothelial-B-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

PKHD1L1 ACKR2 ACSM2A GPRC5B ACSM2B

3.65e-051661005c286987ea4e511195607c87ec4529c2c2ed2122e
ToppCellmild_COVID-19_(asymptomatic)-Plasmablast|World / disease group, cell group and cell class (v2)

PKHD1L1 IGLV3-21 KLHL14 CDC20 TOP2A

3.76e-051671005f26ae4de4804a3486502e3df37eabf3dfca688f5
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D122|Adult / Lineage, Cell type, age group and donor

PKHD1L1 F8 PCSK6 GPRC5B ACSM2B

4.45e-051731005dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCellfacs-Marrow-KLS-18m-Hematologic-Unknown_Progenitor|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHST1 ERMN RAB39B KDF1 CDH2

4.45e-051731005295bfe1efa648173c2d5981025bc61c576baf53f
ToppCellEndothelial-B-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

PKHD1L1 PCSK6 KLHL14 GPRC5B ACSM2B

4.45e-051731005a81992965137195d20fc498f750975303961a828
ToppCell10x_5'_v1-Neoplastic-Stem-like-OPC-like|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

C10orf90 KIF24 CDC20 TOP2A GPRC5B

4.70e-051751005cc596907ea1a64ab7b5a8c7d4ad12e6ee59bfed9
ToppCell10x_5'_v1-Neoplastic-Stem-like|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

C10orf90 KIF24 CDC20 TOP2A GPRC5B

4.70e-051751005a8400e7e47379901dcab5f2e364c3ff17765b4b9
ToppCellInfluenza_Severe-Plasmablast|Influenza_Severe / Disease group and Cell class

FRMPD1 PKHD1L1 IGLV3-21 CDC20 KDF1

4.70e-0517510053f9b9793d3d1b7a9b97899272b6a0d37b05c11d1
ToppCell10x_5'_v1-Neoplastic-Stem-like-OPC-like-OPC-like|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

C10orf90 KIF24 CDC20 TOP2A GPRC5B

4.70e-0517510058a3abf40146ae3459d97cdf865c1c8f6b92ac639
ToppCell10x_5'_v1-Neoplastic-Stem-like-OPC-like-OPC-like-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

C10orf90 KIF24 CDC20 TOP2A GPRC5B

4.70e-051751005378d2b79edac91fc74eee0fb42bb29dd9b07c36f
ToppCellfacs-Marrow-B-cells-18m-Hematologic-Unknown_Progenitor|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDH23 CHST1 ERMN SEL1L3 CDH2

4.82e-0517610055f9ae5eb45603ed0422a3a993ecdbe2ce05d6e45
ToppCellNS-critical-d_16-33-Epithelial-FOXN4+|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CD109 KIF24 PCSK6 CDC20 TOP2A

4.82e-0517610057cf1a06ceee1ec06532f44c729c31b4d58e5ea49
ToppCellVE-plasma|VE / Condition, Cell_class and T cell subcluster

PKHD1L1 IGLV3-21 ENAM KLHL14 CADPS2

4.96e-0517710050c1cc0834de55717cb4f69d020339060ce2c9a03
ToppCellfacs-Marrow-B-cells-18m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDH23 CHST1 ERMN SEL1L3 CDH2

4.96e-05177100535d42b07d9c31528bf59199e361bb8a3bfbe3b75
ToppCellVE-plasma-|VE / Condition, Cell_class and T cell subcluster

PKHD1L1 IGLV3-21 ENAM KLHL14 CADPS2

4.96e-0517710053a3c94cf30012e2aa266bc4d7fe772e45fa90f6d
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC5A10 SEL1L3 ACSM2A CDH2 ACSM2B

5.23e-05179100558ae5a97fe2a14e1c6fdeb886397eb06fdaf0428
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 IP6K3 ACSM2A CDH2 ACSM2B

5.23e-05179100578fae47ec9bff4e0159a86a281e831d7f8ee925a
ToppCellIPF-Epithelial-Mesothelial|IPF / Disease state, Lineage and Cell class

COL8A1 PKHD1L1 C1R CDH2 GPRC5B

5.37e-0518010051fa54bf4dba72866b2295639d991af639341bc08
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAMK4 RPH3A SLC12A5 SEL1L3 CADPS2

5.37e-051801005f6a2208960d0df1500c974cc44c3c054cd7475a9
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)-|367C / Donor, Lineage, Cell class and subclass (all cells)

PKHD1L1 F8 ACKR2 GPRC5B ACSM2B

5.51e-051811005b244ecaa442bbef51289d8ec574ef08fa9e96318
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

C10orf90 PRIMA1 ERMN PCSK6 KEL

5.51e-051811005a8e9ea73c24109a5d4d28bc0577cc869ad932a4d
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)|367C / Donor, Lineage, Cell class and subclass (all cells)

PKHD1L1 F8 ACKR2 GPRC5B ACSM2B

5.51e-051811005dd79de8098edb385a0f85d0e9621503cdf76ec43
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

F9 NUDT12 ADRA1B CDH2 GASK1A

5.66e-051821005770ce9f3f4538d0181a0181543841bc964c68274
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

F9 NUDT12 ADRA1B CDH2 GASK1A

5.66e-05182100577ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

F9 NUDT12 ADRA1B CDH2 GASK1A

5.66e-0518210054921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

C10orf90 PRIMA1 ERMN PCSK6 GPRC5B

5.80e-0518310055472cdce6d99314d229418412acf1fff6340db7d
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

C10orf90 PRIMA1 ERMN PCSK6 GPRC5B

5.80e-05183100593213124e55d1b673dd345188caf8b5bd31d99fe
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD109 PKHD1L1 ENAM CLCN1 ADAMTSL5

5.80e-051831005ebe369dc80c4fbf8f4dbe947147f8c47507ffb60
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

C10orf90 PRIMA1 ERMN PCSK6 GPRC5B

5.96e-051841005f6d6b3ddada66dae28d3306415bf4efe0934208a
ToppCell(6)_Endothelial-F_(Lymphatics)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

PKHD1L1 F8 PCSK6 ACKR2 GPRC5B

5.96e-05184100503ea613e00b45c81b752c14505a0538d698f551e
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

C10orf90 PRIMA1 ERMN PCSK6 GPRC5B

5.96e-0518410055939527d24d299e562e707469c9123890edd76be
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

C10orf90 PRIMA1 ERMN PCSK6 GPRC5B

5.96e-051841005a2191dd5546efd357b23e625beb3c5820476f243
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

HGD CPAMD8 ADRA1B OSMR CADPS2

5.96e-051841005102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

C10orf90 PRIMA1 ERMN PCSK6 GPRC5B

6.11e-051851005b5277190866d9eb5b85eceaa5ba116ea6e6f286b
ToppCell15-Trachea-Epithelial-Multiciliated_precursor|Trachea / Age, Tissue, Lineage and Cell class

KIF24 PCSK6 CDC20 TOP2A CFAP46

6.11e-0518510059a8b8360d99375b726ca8e3c9a3f9b08919892d7
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

C10orf90 PRIMA1 ERMN PCSK6 GPRC5B

6.11e-0518510051d731d69d8db8aef4a11439b8abd1030c7e6ac4c
ToppCell5'-Adult-LargeIntestine-Neuronal-Glial_mature|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL8A1 C10orf90 TMEM132B PRIMA1 CDH2

6.11e-051851005f607b6ee579562e2f92103fa5c7053df0170a229
ToppCell5'-Adult-LargeIntestine-Neuronal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL8A1 C10orf90 TMEM132B PRIMA1 CDH2

6.11e-051851005317f2c854f00aa5957319b818c85eeed7d72ec7f
ToppCell5'-Adult-LargeIntestine-Neuronal-Glial_mature-Adult_Glia|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL8A1 C10orf90 TMEM132B PRIMA1 CDH2

6.11e-0518510057bb8fdfe04f85d25056380ec58222366de323a21
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

IP6K3 C10orf90 PRIMA1 ERMN PCSK6

6.27e-051861005d57c40b3fe5cfc87e771df76533d9a3e94678b04
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

C10orf90 PRIMA1 ERMN PCSK6 GPRC5B

6.27e-05186100590eaf6ffb4ce0c34fa1e79f0c8f36f217f44973b
ToppCell3'-Child04-06-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

F8 ACKR2 ACSM2A GPRC5B ACSM2B

6.27e-05186100530dd4164c101006c8d95922d89652b82dbe4b5ea
ToppCellmild_COVID-19-Plasmablast|mild_COVID-19 / disease group, cell group and cell class (v2)

PKHD1L1 IGLV3-21 ENAM KLHL14 CDC20

6.27e-051861005a639d2183b85b1be6e6da2b2e112aec5149d5bcd
ToppCell(101)_plasma|World / immune cells in Peripheral Blood (logTPM normalization)

PKHD1L1 ENAM ACKR2 KLHL14 CDC20

6.27e-05186100516267994c9ef1fb7118c4c665cbc96979ec2b703
Drugrosiglitazone; Up 200; 10uM; HL60; HT_HG-U133A

PDC TRIO CAMK4 FRMPD1 ARHGEF11 CLCN1 CFAP74 ACKR2

2.29e-061989886192_UP
DiseaseX-21319 measurement

ACSM2A ACSM2B

1.07e-052972EFO_0800807
DiseaseHemophilia A

F8 F9

1.07e-052972C0019069
DiseaseHemophilia

F8 F9

1.07e-052972cv:C0684275
DiseaseFactor VIII Deficiency

F8 F9

1.07e-052972C3494187
DiseaseAutosomal Hemophilia A

F8 F9

1.07e-052972C3494186
Diseaseglucose-dependent insulinotropic peptide measurement, glucose tolerance test

PAPPA2 ARHGEF17 BTNL3

1.22e-0514973EFO_0004307, EFO_0008464
DiseaseX-11478 measurement

ACSM2A ACSM2B

3.20e-053972EFO_0021242
Disease3-hydroxyhexanoate measurement

ACSM2A ACSM2B

1.06e-045972EFO_0800378
DiseaseProlactinoma

CDH23 MEN1

1.59e-046972C0033375
DiseaseVACTERL association (implicated_via_orthology)

PCSK5 QSOX1

1.59e-046972DOID:14679 (implicated_via_orthology)
Diseaseindoleacetoylcarnitine measurement

ACSM2A ACSM2B

1.59e-046972EFO_0800106
Diseasemelanoma (implicated_via_orthology)

GALC KDM2A

2.96e-048972DOID:1909 (implicated_via_orthology)
Diseaseasparaginase-induced acute pancreatitis

NEB CDC20

3.79e-049972EFO_1001507
Diseasenon-alcoholic fatty liver disease, cirrhosis of liver

PCSK5 SEL1L3 CDH2

7.16e-0453973EFO_0001422, EFO_0003095
Diseaseglycerol-3-phosphate measurement

COL8A1 CFAP43

1.09e-0315972EFO_0010488
Diseaseinterferon gamma measurement, platelet-derived growth factor BB measurement, interleukin 4 measurement, interleukin 10 measurement, stromal cell-derived factor 1 alpha measurement, interleukin-6 measurement, interleukin 12 measurement, interleukin 17 measurement, vascular endothelial growth factor measurement, fibroblast growth factor basic measurement, granulocyte colony-stimulating factor measurement

MEN1 PCSK6

1.25e-0316972EFO_0004750, EFO_0004753, EFO_0004762, EFO_0004810, EFO_0008130, EFO_0008142, EFO_0008165, EFO_0008174, EFO_0008184, EFO_0008264, EFO_0008293
DiseaseC-X-C motif chemokine 16 measurement

CDH23 ACKR2

1.58e-0318972EFO_0010911
DiseaseAdrenocortical carcinoma

MEN1 TOP2A

1.58e-0318972C0206686
Diseasebipolar disorder, body mass index

TRIM42 CDH23 TMEM132B

1.74e-0372973EFO_0004340, MONDO_0004985
DiseaseColorectal Carcinoma

CPAMD8 CD109 PRIMA1 SLC12A5 KL MTRR KDM2A KDF1

2.22e-03702978C0009402
Diseaseresponse to selective serotonin reuptake inhibitor

MTMR12 C10orf90 OSMR

2.53e-0382973EFO_0005658
DiseaseKidney Diseases

PCSK5 ADRA1B KL

3.09e-0388973C0022658

Protein segments in the cluster

PeptideGeneStartEntry
WQPSGLVNGTKVEVH

TDRD5

796

Q8NAT2
VFVQTHENPKGVWNC

ACKR2

181

O00590
SGQWQVTGPGKFVQA

BTNL3

16

Q6UXE8
FTQHQGAVKAVAWCP

CDC20

351

Q12834
VRWVQGFPKQNVHFV

CFAP43

21

Q8NDM7
VSLQWGHQEVPAKFN

ACSM2A

31

Q08AH3
GQAWVHGAEPRQVFQ

FAT4

36

Q6V0I7
WQAGHSIFQAKAVDP

FAT4

906

Q6V0I7
PDAQNWQHTVGKDVV

ARHGEF11

711

O15085
LGSKHFPSQAQWEQA

CFAP46

2456

Q8IYW2
GFGAQIPPQWQVSHE

CPNE3

346

O75131
HAGQAWVPEKQEGRV

DPPA4

251

Q7L190
HWGELKNANFTGPNQ

ADRA1B

16

P35368
VAQQQGAWLPHVADF

COMMD5

141

Q9GZQ3
KMGNFPWQVFTNIHG

C1R

471

P00736
VKAWDPDAGSNGQVV

CDH23

1441

Q9H251
WRVKPGQDQAHQAGE

RBPJL

101

Q9UBG7
WEGVKSGFVPNVVHS

RAB39B

186

Q96DA2
QDVLGDFQWKNVGPN

OSMR

566

Q99650
KKVNWIGCQGSEPHF

QSOX1

386

O00391
HAWVVFGPNGEQTAE

MEN1

186

O00255
GHFWDPQNFKSVTLG

ARHGEF17

1801

Q96PE2
TGDNWKFIGPDQHRN

PTCD3

441

Q96EY7
PWFHGKISGQEAVQQ

MATK

121

P42679
GQHSQAAPVKWIFQD

LRIF1

281

Q5T3J3
HQWLENNIGVKPRSG

MAN2A1

271

Q16706
EENVQRFQGHGIPIW

MTMR12

251

Q9C0I1
TFQALQHPWVTGKAA

CAMK4

291

Q16566
FVGQPAAEHQWDEQG

LRRC25

246

Q8N386
KLQEQHPDGNFGAMW

MTRR

561

Q9UBK8
EVQQKQGSPHQEWFT

FAM184B

1041

Q9ULE4
WPQREKGIQGHQASE

IL12RB2

726

Q99665
QVLQHPWIETAGKTN

DCLK3

606

Q9C098
TNHWAVKIAGGFPEA

PCSK5

36

Q92824
TNHWAVQVLGGPAEA

PCSK6

71

P29122
QATHTGPKGVINDWR

PDC

16

P20941
GQFPWQVVLNGKVDA

F9

236

P00740
FLHQTWGQGPEKQVA

KIF24

856

Q5T7B8
IGSKSVHWYQQKPGQ

IGLV3-21

46

P80748
GSHTYVWQVLKENGP

F8

151

P00451
EGHQWEKIPLSGSNQ

ERMN

111

Q8TAM6
TNGNQVERKSFNPWG

IP6K3

161

Q96PC2
VLGTQKTYQWVPFHG

ADAMTSL5

116

Q6ZMM2
IGSKAVHWYQQKPGQ

IGLV3-12

46

A0A075B6K2
FGNVKLQQGDAWNDP

GPRC5B

256

Q9NZH0
GETWHKGGILANKQN

PREP

511

P48147
WVKARNQHGEVGFVP

FCHSD1

506

Q86WN1
AFTVEAWVKPEGGQN

PAPPA2

286

Q9BXP8
AHQWPGSVEKLQGSV

GASK1A

226

Q9UFP1
QKSNGEFWDPGRVIH

CD109

1021

Q6YHK3
VLGGEDQWNPNGKHS

KLHL14

376

Q9P2G3
QGGKVFWLIPPTAHN

KDM2A

226

Q9Y2K7
NALAGIWVKNHGNPI

FBXO11

431

Q86XK2
AGDSLAGNFHPEVQW

FGL1

211

Q08830
VTSIFLWPGNKQQAH

FRMPD1

496

Q5SYB0
GWQAEEGPLFHNQTS

CPAMD8

106

Q8IZJ3
HRGFEQETWQPVKNI

CADPS2

951

Q86UW7
GGNVWVALFKNNEPV

COL8A1

671

P27658
IPQNGFWTLEMHKGQ

BTN2A1

416

Q7KYR7
NHPQIFIVENGWFVS

KL

406

Q9UEF7
GLQKNPIWHEGENLN

ENAM

816

Q9NRM1
VNFPKNGWAAIGTHS

GALC

656

P54803
EFLHQVWNGTVPEGS

CDH2

266

P19022
IWVADQNKPVGFTVH

CFAP74

896

Q9C0B2
QVFGHGKANGEPTWA

SLC12A5

546

Q9H2X9
AKQDVSPFNVVAWHG

HGD

256

Q93099
EKNGAHSVTQAGVQW

SNX29P2

221

Q8IUI4
VFKVRAINDNGPGQW

TRIM42

676

Q8IWZ5
WGQQGVAKNPEAAIE

SEL1L3

701

Q68CR1
KEQLQAGWSVHPGGQ

RPH3A

26

Q9Y2J0
GKWENNIHSGLESPQ

TMEM132B

236

Q14DG7
QNAGGKSWAPEIATH

NIN

1811

Q8N4C6
KQAGGNPWHQFVENN

PDPK1

441

O15530
LWGFVQVTHGEPQKS

PRIMA1

26

Q86XR5
VNFQEEEGGWTPLHN

RNASEL

51

Q05823
GVKVGHVQYVACQPW

NUDT12

376

Q9BQG2
GTAEANWAKEHNGVP

KDF1

121

Q8NAX2
LSAPISEWNGKQGHI

CYB5R4

456

Q7L1T6
RQSHVWEQKVGGVSP

SSH3

471

Q8TE77
VSLQWGHQEVPAKFN

ACSM2B

31

Q68CK6
WIQNNTRGDPTLGKH

CHST1

331

O43916
NTWVKHAGDPESLGQ

CLCN1

431

P35523
VGQRWNPGLQESHLK

C10orf90

331

Q96M02
TKPLGTQVAVNAHQW

SEPHS2

251

Q99611
SVGWGNIFQLPFKHV

UNC93B1

321

Q9H1C4
WLHGENGTGPAKFNI

NHLRC3

201

Q5JS37
AGDGQTPQKHAFWAR

SLC5A10

561

A0PJK1
GHGFSNLPWANKVTI

PKHD1L1

1586

Q86WI1
HVWPGTDGFLKDNNN

ZFYVE1

541

Q9HBF4
ISIWNNGKGIPVVEH

TOP2A

116

P11388
QTNPNKVHWDQVFAG

ZNF821

6

O75541
WAQHEGKESPEQQGR

STRCP1

1731

A6NGW2
PWTAELQLHGKGQLQ

TMEM234

131

Q8WY98
ITWKGPEHNTLNNDG

TRIO

2716

O75962
GAWDNQKGHPLPENQ

TNRC6B

536

Q9UPQ9
QKNATGFWNPQTEAH

TAS2R4

211

Q9NYW5
VPQEKATAWHGFGEN

ZNF554

211

Q86TJ5
QNSWHPGSGEEKAFQ

KEL

136

P23276
VPIEQKHEVWGSNQN

N4BP1

466

O75113
AIKVNDSVPFHLGWN

MYORG

236

Q6NSJ0
PKLVWFEHAGQIQNE

NEB

4271

P20929