Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity	PDE1A PDE1B	5.88e-05	3	89	2	GO:0048101
GeneOntologyMolecularFunction	calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity	PDE1A PDE1B	5.88e-05	3	89	2	GO:0004117
GeneOntologyCellularComponent	anchoring junction	FZD1 FLNB DCHS2 FAT2 DST ATP7B HYOU1 RDX WDR1 TEC LCP1 CDH8 PHLDB2 ABCB4 JAM2	1.10e-05	976	87	15	GO:0070161
GeneOntologyCellularComponent	cell-cell junction	DCHS2 FAT2 DST ATP7B RDX WDR1 TEC CDH8 ABCB4 JAM2	1.71e-04	591	87	10	GO:0005911
GeneOntologyCellularComponent	growth hormone receptor complex	CSH1 CSH2	2.54e-04	6	87	2	GO:0070195
GeneOntologyCellularComponent	focal adhesion	FZD1 FLNB DST HYOU1 RDX LCP1 PHLDB2 ABCB4	4.31e-04	431	87	8	GO:0005925
GeneOntologyCellularComponent	cell-substrate junction	FZD1 FLNB DST HYOU1 RDX LCP1 PHLDB2 ABCB4	5.17e-04	443	87	8	GO:0030055
Domain	PDEase_N	PDE1A PDE1B	6.42e-05	3	87	2	IPR013706
Domain	PDEase_I_N	PDE1A PDE1B	6.42e-05	3	87	2	PF08499
Domain	Actinin_actin-bd_CS	FLNB DST LCP1	1.62e-04	23	87	3	IPR001589
Domain	ACTININ_2	FLNB DST LCP1	1.62e-04	23	87	3	PS00020
Domain	ACTININ_1	FLNB DST LCP1	1.62e-04	23	87	3	PS00019
Domain	SOMATOTROPIN_2	CSH1 CSH2	3.18e-04	6	87	2	PS00338
Domain	Hormone_1	CSH1 CSH2	3.18e-04	6	87	2	PF00103
Domain	SOMATOTROPIN_1	CSH1 CSH2	3.18e-04	6	87	2	PS00266
Domain	-	FLNB DST LCP1 CAMSAP2	3.36e-04	71	87	4	1.10.418.10
Domain	CH	FLNB DST LCP1 CAMSAP2	3.74e-04	73	87	4	PS50021
Domain	CH-domain	FLNB DST LCP1 CAMSAP2	4.15e-04	75	87	4	IPR001715
Domain	Somatotropin	CSH1 CSH2	4.44e-04	7	87	2	IPR001400
Domain	WD40_repeat_CS	NWD1 RAE1 WDR1 SPAG16 TEP1	1.02e-03	164	87	5	IPR019775
Domain	ZnF_GATA	TRPS1 RERE	1.37e-03	12	87	2	SM00401
Domain	Znf_GATA	TRPS1 RERE	2.17e-03	15	87	2	IPR000679
Domain	GATA	TRPS1 RERE	2.17e-03	15	87	2	PF00320
Domain	GATA_ZN_FINGER_1	TRPS1 RERE	2.47e-03	16	87	2	PS00344
Domain	GATA_ZN_FINGER_2	TRPS1 RERE	2.47e-03	16	87	2	PS50114
Domain	Zn_pept	CPA3 CPD	3.13e-03	18	87	2	SM00631
Domain	CH	FLNB DST LCP1	3.46e-03	65	87	3	SM00033
Domain	PDEase	PDE1A PDE1B	3.48e-03	19	87	2	IPR023088
Domain	CARBOXYPEPT_ZN_2	CPA3 CPD	3.48e-03	19	87	2	PS00133
Domain	CARBOXYPEPT_ZN_1	CPA3 CPD	3.86e-03	20	87	2	PS00132
Domain	PDEase_I	PDE1A PDE1B	4.25e-03	21	87	2	PF00233
Domain	PDEASE_I	PDE1A PDE1B	4.25e-03	21	87	2	PS00126
Domain	PDEase_CS	PDE1A PDE1B	4.25e-03	21	87	2	IPR023174
Domain	CH	FLNB DST LCP1	4.27e-03	70	87	3	PF00307
Domain	-	NWD1 RAE1 SEMA5A WDR1 SPAG16 TEP1	4.62e-03	333	87	6	2.130.10.10
Domain	-	PDE1A PDE1B	4.66e-03	22	87	2	1.10.1300.10
Domain	WD40/YVTN_repeat-like_dom	NWD1 RAE1 SEMA5A WDR1 SPAG16 TEP1	4.76e-03	335	87	6	IPR015943
Domain	Peptidase_M14	CPA3 CPD	5.09e-03	23	87	2	PF00246
Domain	Peptidase_M14	CPA3 CPD	5.09e-03	23	87	2	IPR000834
Domain	PDEase_catalytic_dom	PDE1A PDE1B	5.09e-03	23	87	2	IPR002073
Domain	HDc	PDE1A PDE1B	5.54e-03	24	87	2	SM00471
Domain	HD/PDEase_dom	PDE1A PDE1B	5.54e-03	24	87	2	IPR003607
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	TPP2 ATP7B HYOU1 LMAN1 RAE1 RADX UNK RDX FKBP7 UGGT2 IDE METTL16 PHLDB2	7.48e-08	754	90	13	33060197
Pubmed	Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development.	DCHS2 FAT2 CSH1 CSH2	1.25e-07	18	90	4	33108146
Pubmed	Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis.	CSH1 CSH2 ABCB4	5.82e-07	7	90	3	25179284
Pubmed	Growth hormone synergizes with BMP9 in osteogenic differentiation by activating the JAK/STAT/IGF1 pathway in murine multilineage cells.	CSH1 CSH2 STAT1	1.39e-06	9	90	3	22467218
Pubmed	Analysis of a major human chorionic somatomammotropin gene. Evidence for two functional promoter elements.	CSH1 CSH2	6.62e-06	2	90	2	6208192
Pubmed	Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo.	PARP4 TEP1	6.62e-06	2	90	2	15169895
Pubmed	Multiple origins of transcription for the human placental lactogen genes.	CSH1 CSH2	6.62e-06	2	90	2	6209277
Pubmed	Identification of the interchain disulfide bonds of dimeric human placental lactogen.	CSH1 CSH2	6.62e-06	2	90	2	438159
Pubmed	Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants.	PDE1A PDE1B	6.62e-06	2	90	2	11747989
Pubmed	Amino acid sequence of human chorionic somatomammotropin.	CSH1 CSH2	6.62e-06	2	90	2	4712450
Pubmed	Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5.	CYP2E1 CPD	6.62e-06	2	90	2	16799984
Pubmed	Increased susceptibility of vault poly(ADP-ribose) polymerase-deficient mice to carcinogen-induced tumorigenesis.	PARP4 TEP1	6.62e-06	2	90	2	16204055
Pubmed	Amino-acid sequence of human placental lactogen.	CSH1 CSH2	6.62e-06	2	90	2	5286363
Pubmed	Two structurally different genes produce the same secreted human placental lactogen hormone.	CSH1 CSH2	6.62e-06	2	90	2	6300056
Pubmed	Cotranslational sequestration of egg white proteins and placental lactogen inside membrane vesicles.	CSH1 CSH2	6.62e-06	2	90	2	6930851
Pubmed	Construction and analysis of recombinant DNA for human chorionic somatomammotropin.	CSH1 CSH2	6.62e-06	2	90	2	593368
Pubmed	Human placental lactogen induces CYP2E1 expression via PI 3-kinase pathway in female human hepatocytes.	CSH1 CYP2E1	6.62e-06	2	90	2	24408518
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	FLNB PARP4 MYO9B MROH7 DHX57 PRPF8	1.48e-05	202	90	6	33005030
Pubmed	The Cockayne syndrome B protein, involved in transcription-coupled DNA repair, resides in an RNA polymerase II-containing complex.	CSH1 CSH2	1.98e-05	3	90	2	9312053
Pubmed	MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells.	PARP4 TEP1	1.98e-05	3	90	2	34829999
Pubmed	Differential placental expression profile of human Growth Hormone/Chorionic Somatomammotropin genes in pregnancies with pre-eclampsia and gestational diabetes mellitus.	CSH1 CSH2	1.98e-05	3	90	2	22387044
Pubmed	The human growth hormone gene locus: structure, evolution, and allelic variations.	CSH1 CSH2	1.98e-05	3	90	2	3030680
Pubmed	Expression profiles of vault components MVP, TEP1 and vPARP and their correlation to other multidrug resistance proteins in ovarian cancer.	PARP4 TEP1	1.98e-05	3	90	2	23739867
Pubmed	Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase.	PDE1A PDE1B	1.98e-05	3	90	2	9003415
Pubmed	Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+.	PDE1A PDE1B	1.98e-05	3	90	2	18335582
Pubmed	Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons.	PDE1A PDE1B	1.98e-05	3	90	2	7568196
Pubmed	Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster.	CSH1 CSH2	1.98e-05	3	90	2	15531513
Pubmed	Splicing variants of the human growth hormone mRNA: detection in pituitary, mononuclear cells and dermal fibroblasts.	CSH1 CSH2	1.98e-05	3	90	2	8674830
Pubmed	Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8+ T-Cell Activation.	GAB3 GAB2	1.98e-05	3	90	2	30936879
Pubmed	Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes.	PDE1A PDE1B	1.98e-05	3	90	2	17726023
Pubmed	Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation.	GAB3 GAB2	1.98e-05	3	90	2	11997510
Pubmed	Identification of functional CCAAT/enhancer-binding protein and Ets protein binding sites in the human chorionic somatomammotropin enhancer sequences.	CSH1 CSH2	3.96e-05	4	90	2	21737519
Pubmed	Assignment of the human helix-loop-helix transcription factor gene musculin/activated B-cell factor-1 (MSC) to chromosome 8q21 and its mouse homologue (Msc) to the proximal region of chromosome 1.	DST MYBL1	3.96e-05	4	90	2	10198176
Pubmed	The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone.	CSH1 CSH2	3.96e-05	4	90	2	7169009
Pubmed	Developmental control and alternative splicing of the placentally expressed transcripts from the human growth hormone gene cluster.	CSH1 CSH2	3.96e-05	4	90	2	1378436
Pubmed	Characterization of the mouse JAB1 cDNA and protein.	DST MYBL1	3.96e-05	4	90	2	10721695
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	FLNB HYOU1 LMAN1 OTOL1 CPD IDE WDR1 EDEM1 LCP1 PRPF8 ABTB2	4.35e-05	974	90	11	28675297
Pubmed	EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.	HYOU1 LMAN1 UGGT2 EDEM1 MFN1	4.57e-05	150	90	5	32423001
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PARP4 DST HYOU1 RDX DHX57 PAPLN UGGT2 METTL16 EDEM1	4.84e-05	650	90	9	38777146
Pubmed	Central growth hormone action regulates metabolism during pregnancy.	CSH1 CSH2	6.59e-05	5	90	2	31479305
Pubmed	Molecular evolution of growth hormone and receptor in the guinea-pig, a mammal unresponsive to growth hormone.	CSH1 CSH2	6.59e-05	5	90	2	10767558
Pubmed	Heterogeneous growth hormone (GH) gene mutations in familial GH deficiency.	CSH1 CSH2	6.59e-05	5	90	2	8496314
Pubmed	Exploring endocrine GH pattern in mice using rank plot analysis and random blood samples.	CSH1 CSH2	6.59e-05	5	90	2	21045135
Pubmed	Analysis of gender difference of cardiac risk biomarkers using hGH-transgenic mice.	CSH1 CSH2	6.59e-05	5	90	2	16508206
Pubmed	Rescue of pituitary function in a mouse model of isolated growth hormone deficiency type II by RNA interference.	CSH1 CSH2	6.59e-05	5	90	2	18006625
Pubmed	Growth hormone overexpression in the central nervous system results in hyperphagia-induced obesity associated with insulin resistance and dyslipidemia.	CSH1 CSH2	6.59e-05	5	90	2	15616010
Pubmed	Nitric oxide stimulates embryonic somatotroph differentiation and growth hormone mRNA and protein expression through a cyclic guanosine monophosphate-independent mechanism.	CSH1 CSH2	6.59e-05	5	90	2	19019400
Pubmed	The Effects of 20-kDa Human Placental GH in Male and Female GH-deficient Mice: An Improved Human GH?	CSH1 CSH2	6.59e-05	5	90	2	32556100
Pubmed	High frequency of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice created from two different strains of mice.	CSH1 CSH2	6.59e-05	5	90	2	1525063
Pubmed	Obesity and elevated plasma leptin concentration in oMT1A-o growth hormone transgenic mice.	CSH1 CSH2	6.59e-05	5	90	2	11346667
Pubmed	Cardiac contractile function is enhanced in isolated ventricular myocytes from growth hormone transgenic mice.	CSH1 CSH2	6.59e-05	5	90	2	12010633
Pubmed	Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis.	CSH1 CSH2	6.59e-05	5	90	2	17626886
Pubmed	Growth hormone prevents the development of autoimmune diabetes.	CSH1 CSH2	6.59e-05	5	90	2	24218587
Pubmed	Regulation of rapid signal transducer and activator of transcription-5 phosphorylation in the resting cells of the growth plate and in the liver by growth hormone and feeding.	CSH1 CSH2	6.59e-05	5	90	2	19359380
Pubmed	Body composition of inactivated growth hormone (oMt1a-oGH) transgenic mice: generation of an obese phenotype.	CSH1 CSH2	6.59e-05	5	90	2	9546108
Pubmed	Transgene transmission to progeny by oMt1a-oGH transgenic mice.	CSH1 CSH2	6.59e-05	5	90	2	16201410
Pubmed	Growth hormone stimulates the selective trafficking of thymic CD4+CD8- emigrants to peripheral lymphoid organs.	CSH1 CSH2	6.59e-05	5	90	2	15316240
Pubmed	Genes that prolong life: relationships of growth hormone and growth to aging and life span.	CSH1 CSH2	6.59e-05	5	90	2	11487592
Pubmed	Overexpressed growth hormone (GH) synergistically promotes carcinogen-initiated liver tumour growth by promoting cellular proliferation in emerging hepatocellular neoplasms in female and male GH-transgenic mice.	CSH1 CSH2	6.59e-05	5	90	2	11318985
Pubmed	Involvement of insulin-like growth factor-1 in the effect of caloric restriction: regulation of plasma adiponectin and leptin.	CSH1 CSH2	6.59e-05	5	90	2	17301034
Pubmed	Growth hormone action in the developing neural retina: a proteomic analysis.	CSH1 CSH2	6.59e-05	5	90	2	18203262
Pubmed	Identification of the glomerular podocyte as a target for growth hormone action.	CSH1 CSH2	6.59e-05	5	90	2	17272398
Pubmed	Glucose homeostasis and insulin sensitivity in growth hormone-transgenic mice: a cross-sectional analysis.	CSH1 CSH2	6.59e-05	5	90	2	20707609
Pubmed	Assignment of the porcine growth hormone gene to chromosome 12.	CSH1 CSH2	6.59e-05	5	90	2	2249485
Pubmed	Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARgamma pathway.	CSH1 CSH2	6.59e-05	5	90	2	17242167
Pubmed	A single injection of double-stranded adeno-associated viral vector expressing GH normalizes growth in GH-deficient mice.	CSH1 CSH2	6.59e-05	5	90	2	18180319
Pubmed	Induction of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice.	CSH1 CSH2	6.59e-05	5	90	2	1874564
Pubmed	Cloning and characterisation of the GH gene from the common dolphin (Delphinus delphis).	CSH1 CSH2	6.59e-05	5	90	2	12225773
Pubmed	Growth Hormone Deficiency and Excess Alter the Gut Microbiome in Adult Male Mice.	CSH1 CSH2	6.59e-05	5	90	2	32100023
Pubmed	The related genes encoding growth hormone and prolactin have been dispersed to chromosomes 10 and 17 in the rat.	CSH1 CSH2	6.59e-05	5	90	2	3780533
Pubmed	High, persistent hepatocellular proliferation and apoptosis precede hepatocarcinogenesis in growth hormone transgenic mice.	CSH1 CSH2	6.59e-05	5	90	2	10395045
Pubmed	Effect of genetic background on growth of mice hemizygous for wild-type or dwarf mutated bovine growth hormone transgenes.	CSH1 CSH2	6.59e-05	5	90	2	24190208
Pubmed	Brief report: short stature caused by a mutant growth hormone.	CSH1 CSH2	6.59e-05	5	90	2	8552145
Pubmed	Promotion of Joint Degeneration and Chondrocyte Metabolic Dysfunction by Excessive Growth Hormone in Mice.	CSH1 CSH2	6.59e-05	5	90	2	36762426
Pubmed	High molecular weight isoforms of growth hormone in cells of the immune system.	CSH1 CSH2	6.59e-05	5	90	2	21741628
Pubmed	Structure of the growth hormone-encoding gene and its promoter in mice.	CSH1 CSH2	6.59e-05	5	90	2	8647448
Pubmed	Thiol-Disulfide Exchange in Human Growth Hormone.	CSH1 CSH2	6.59e-05	5	90	2	26887678
Pubmed	Transgenic mice expressing bovine GH develop arthritic disorder and self-antibodies.	CSH1 CSH2	6.59e-05	5	90	2	10810296
Pubmed	The role of growth hormone in fetal mouse reproductive tract differentiation.	CSH1 CSH2	6.59e-05	5	90	2	8756530
Pubmed	GH Knockout Mice Have Increased Subcutaneous Adipose Tissue With Decreased Fibrosis and Enhanced Insulin Sensitivity.	CSH1 CSH2	6.59e-05	5	90	2	31099824
Pubmed	Somatotropin transgenic mice have reduced jejunal active glucose transport rates.	CSH1 CSH2	6.59e-05	5	90	2	7965203
Pubmed	Hot spots for growth hormone gene deletions in homologous regions outside of Alu repeats.	CSH1 CSH2	6.59e-05	5	90	2	1980158
Pubmed	Vitamin D3 cannot revert desensitization of growth hormone (GH)-induced STAT5-signaling in GH-overexpressing mice non-calcemic tissues.	CSH1 CSH2	6.59e-05	5	90	2	17881271
Pubmed	Neural growth hormone implicated in body weight sex differences.	CSH1 CSH2	6.59e-05	5	90	2	23861378
Pubmed	Growth hormone increases low-density lipoprotein receptor and HMG-CoA reductase mRNA expression in mesangial cells.	CSH1 CSH2	6.59e-05	5	90	2	12759574
Pubmed	Growth hormone production and action in N1E-115 neuroblastoma cells.	CSH1 CSH2	6.59e-05	5	90	2	19301152
Pubmed	Adipocyte insensitivity to insulin in growth hormone-transgenic mice.	CSH1 CSH2	6.59e-05	5	90	2	11350075
Pubmed	Transgenic mice overexpressing growth hormone (GH) have reduced or increased cardiac apoptosis through activation of multiple GH-dependent or -independent cell death pathways.	CSH1 CSH2	6.59e-05	5	90	2	18617616
Pubmed	Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice.	CSH1 CSH2	6.59e-05	5	90	2	17347312
Pubmed	Growth hormone and fertility in oMt1a-oGH transgenic mice.	CSH1 CSH2	6.59e-05	5	90	2	11570960
Pubmed	Promoter shuffling has occurred during the evolution of the vertebrate growth hormone gene.	CSH1 CSH2	6.59e-05	5	90	2	10974531
Pubmed	Pleiotropic effects of growth hormone signaling in aging.	CSH1 CSH2	6.59e-05	5	90	2	21852148
Pubmed	Body composition, bone mass and microstructural analysis in GH-transgenic mice reveals that skeletal changes are specific to bone compartment and gender.	CSH1 CSH2	6.59e-05	5	90	2	12175649
Pubmed	Transgenic mice reveal novel activities of growth hormone in wound repair, angiogenesis, and myofibroblast differentiation.	CSH1 CSH2	6.59e-05	5	90	2	15070902
Pubmed	Hepatocellular alterations and dysregulation of oncogenic pathways in the liver of transgenic mice overexpressing growth hormone.	CSH1 CSH2	6.59e-05	5	90	2	23428905
Pubmed	A novel missense mutation in the mouse growth hormone gene causes semidominant dwarfism, hyperghrelinemia, and obesity.	CSH1 CSH2	6.59e-05	5	90	2	14726450
Pubmed	UV photodegradation of murine growth hormone: chemical analysis and immunogenicity consequences.	CSH1 CSH2	6.59e-05	5	90	2	24758742
Pubmed	Consequences of overexpression of growth hormone in transgenic mice on liver cytochrome P450 enzymes.	CSH1 CSH2	6.59e-05	5	90	2	10076541
Pubmed	Overgrowth of skin in growth hormone transgenic mice depends on the presence of male gonads.	CSH1 CSH2	6.59e-05	5	90	2	10594738
Pubmed	Hypoxia and cytoplasmic alkalinization upregulate growth hormone expression in lymphocytes.	CSH1 CSH2	6.59e-05	5	90	2	23639351
GeneFamily	Growth hormone family	CSH1 CSH2	1.89e-04	6	65	2	1175
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	TRPS1 RERE	1.30e-03	15	65	2	82
GeneFamily	Cadherin related	DCHS2 FAT2	1.67e-03	17	65	2	24
GeneFamily	WD repeat domain containing	NWD1 RAE1 WDR1 SPAG16 TEP1	2.50e-03	262	65	5	362
GeneFamily	Carboxypeptidases	CPA3 CPD	2.56e-03	21	65	2	1321
GeneFamily	Phosphodiesterases	PDE1A PDE1B	3.34e-03	24	65	2	681
GeneFamily	SH2 domain containing	SHE TEC STAT1	5.75e-03	101	65	3	741
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	GAB3 TEC GAB2 PHLDB2	6.45e-03	206	65	4	682
Coexpression	GSE29164_DAY3_VS_DAY7_CD8_TCELL_TREATED_MELANOMA_DN	VRK2 FAT2 CEP41 GATM UGGT2 GSAP NUDT15	5.50e-06	200	89	7	M8494
ToppCell	PSB-critical-LOC-Epithelial-Basal\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FAT2 DST SULT2B1 SEMA5A CMYA5 PHLDB2 FAM83B	1.63e-07	199	90	7	2add64c3e4cb6384ec381f34c3f1f77e13e3f27c
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Sla\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	B3GALT2 NDST3 PDE1A VRK2 ETV4 CMYA5	9.63e-07	162	90	6	4d13c271b4f63cf32980e5643b5d5951165fe8b5
ToppCell	NS-moderate-d_0-4-Myeloid-pDC\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	B3GALT2 RADX INPP4A GAB3 EDEM1 LCP1	1.61e-06	177	90	6	de1ffe3df76100d46ca158bdd2fea2ebbd4656b4
ToppCell	wk_15-18-Hematologic-Myeloid-Basophil\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PDE1B MYO9B GAB3 CPA3 TEC ADAM28	2.29e-06	188	90	6	3638d85452de15a060146628fbbad9d2a36feb13
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLNB FAT2 CYP2E1 SULT2B1 TMPRSS11A FAM83B	3.08e-06	198	90	6	e06d41a7254a09e037ec404be2d8c352d5cbd7f4
ToppCell	NS-control-d_0-4-Epithelial-Secretory\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FLNB FAT2 SEMA5A CPD CMYA5 ADAM28	3.17e-06	199	90	6	32bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCell	Bronchial_Brush-Epithelial-Basal_2\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	FAT2 DST SULT2B1 SEMA5A ADAM28 PHLDB2	3.27e-06	200	90	6	1fa29a9f42987549a75dffeb177099458f7cca88
ToppCell	proximal-3-Epithelial-Proximal_Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FAT2 SULT2B1 SEMA5A CMYA5 ADAM28 FAM83B	3.27e-06	200	90	6	3a0c84f9a551fc2581ec3693481eada297d83f7b
ToppCell	Bronchial_Brush-Epithelial-Basal_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	FAT2 DST SULT2B1 SEMA5A ADAM28 PHLDB2	3.27e-06	200	90	6	7595eb2a8af3de879ecaa71f3d96f890e13b59ce
ToppCell	Control_saline-Hematopoietic_Myeloid-Granulocytic_cells-Mast-cells\|Control_saline / Treatment groups by lineage, cell group, cell type	B3GALT2 DHDH MROH7 CPA3 TEC LCP1	3.27e-06	200	90	6	58b25dc2d29e98354bfc8e8e161796c237c3dc23
ToppCell	proximal-Epithelial-Proximal_Basal-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FAT2 SULT2B1 SEMA5A CMYA5 ADAM28 FAM83B	3.27e-06	200	90	6	de9aec87c86ad0a1bd5e0737c2aae0ec6f269bca
ToppCell	proximal-Epithelial-Proximal_Basal\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FAT2 SULT2B1 SEMA5A CMYA5 ADAM28 FAM83B	3.27e-06	200	90	6	ff2afa5c0352c214525129f9ff85afc139fe44d2
ToppCell	COVID-19_Convalescent-PLT_3\|World / Disease Group and Platelet Clusters	MEMO1 FLNB DENND1B KDM1B SCAI	8.69e-06	137	90	5	bb54bb81b450462ad521b57e1a07a80ce1678e67
ToppCell	LPS-IL1RA-Hematopoietic_Mast-Mast_cells-Mast-cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CCDC69 B3GALT2 DENND1B CPA3 TEC	9.32e-06	139	90	5	f1d1a51a79afdddc82e73cd29b3240e3e973db28
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FZD1 MROH7 ADAM28 MYBL1 ABCB4	1.07e-05	143	90	5	5a279da1cd8e63db32f7c85a73b493c2121d0a96
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FZD1 MROH7 ADAM28 MYBL1 ABCB4	1.14e-05	145	90	5	997bd540c43725a85ca97e4b79ebe0d336860287
ToppCell	facs-Marrow-KLS-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 FBXO25 DST SULT2B1 ANGPT4	1.68e-05	157	90	5	5d08ff0ba9d3df9cc30f13cab2d2b395ea6f3446
ToppCell	facs-Marrow-KLS-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 FBXO25 DST SULT2B1 ANGPT4	1.68e-05	157	90	5	ad9c9b7dfeee3ae46e7e593c51a0407df12195b4
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VRK2 DENND1B GVINP1 SYT4 STAT1	2.60e-05	172	90	5	3f784aed340b50ddbec3f7dc0a5279180d38a2bb
ToppCell	facs-Marrow-B-cells-24m-Hematologic-hematopoietic_stem_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LMAN1 SULT2B1 PAPLN EDEM1 CDH8	2.60e-05	172	90	5	a7fd4d61fb5017dce001d69d6b9a01e6cdf58828
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|normal_Lymph_Node / Location, Cell class and cell subclass	DST SPRED2 HYOU1 EDEM1 MFN1	2.91e-05	176	90	5	476794ef75ce5ab732d78cfeb4944e2f841e3e92
ToppCell	BAL-Mild-cDC_3\|Mild / Compartment, Disease Groups and Clusters	RADX SFXN2 GAB3 IDE ADAM28	2.91e-05	176	90	5	f9b0c3ced391e7ebe6b242d3f12ba14741f88d22
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VRK2 DENND1B SYT4 STAT1 GAB2	2.99e-05	177	90	5	14fb8d182775dfd0e49aa7e4e12543a85b3b8bd6
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PARP4 PDE1A OTOL1 CDH8 PHLDB2	3.24e-05	180	90	5	8923a42a6db9c6e9f3ce2ca9530e620dfea700ba
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	B3GALT2 PDE1A TRPS1 ETV4 SEMA5A	3.24e-05	180	90	5	e8841ef1239f9ee73ac4f4e11faca0742694f368
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB DST SHE ABCB4 JAM2	3.32e-05	181	90	5	4ea02344e1996f264dd5e14f3b19c8782ce41699
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Tcf7l2_(Entopeduncular_Nucleus_(Ent))--\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	DCHS2 RADX MROH7 PAPLN	3.35e-05	90	90	4	27865bd63dda0624e62a3b713464a490b588d3ae
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Tcf7l2_(Entopeduncular_Nucleus_(Ent))\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	DCHS2 RADX MROH7 PAPLN	3.35e-05	90	90	4	8c2eb7444f938faade7c81a60c004252d588c80b
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Tcf7l2_(Entopeduncular_Nucleus_(Ent))-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	DCHS2 RADX MROH7 PAPLN	3.35e-05	90	90	4	4bc53b521abb79fc53ac912f1dc2e3c55426b2e0
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE1A TRPS1 ETV4 SEMA5A PHLDB2	3.41e-05	182	90	5	72e65a23cd36085bc880087d3cae92395de918a1
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE1A TRPS1 ETV4 SEMA5A PHLDB2	3.41e-05	182	90	5	05c167158815bf25d509df59ab386e1990712765
ToppCell	FLU-Healthy-0\|FLU / Virus stimulation, Condition and Cluster	CCDC69 LCP1 STAT1 MYBL1 JAM2	3.50e-05	183	90	5	058604ddb06b3bef131183d86b83b422dae8f6cb
ToppCell	FLU-Healthy-0\|Healthy / Virus stimulation, Condition and Cluster	CCDC69 LCP1 STAT1 MYBL1 JAM2	3.50e-05	183	90	5	7a6f18246c39864479e114f698581f667fa9c600
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_11\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DST DENND1B CYP2E1 ADAM28 ABCB4	3.59e-05	184	90	5	667846c422cfa27e949a24844a305df859cb6760
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like\|lymph-node_spleen / Manually curated celltypes from each tissue	B3GALT2 DST CYP2E1 TEC MYBL1	3.59e-05	184	90	5	d97471a4fe17cba6880ccf1a04cc00c741558124
ToppCell	Control-Epithelial-Basal\|Epithelial / Disease state, Lineage and Cell class	FAT2 DST SEMA5A ADAM28 FAM83B	3.69e-05	185	90	5	d5d6d13e2f20b54ca55645b9a757b8599f4fd897
ToppCell	normal_Lymph_Node-B_lymphocytes-GC_B_cells_in_the_LZ\|B_lymphocytes / Location, Cell class and cell subclass	CCDC69 SPRED2 WDR1 LCP1 MYBL1	3.88e-05	187	90	5	457eb3791a8c5458d81833e0701ac5a9bfdee2bf
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FLNB DST SEMA5A PHLDB2 SCAI	3.88e-05	187	90	5	d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCell	368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)\|368C / Donor, Lineage, Cell class and subclass (all cells)	PARP4 HSD17B6 METTL16 MFN1 SCAI	3.88e-05	187	90	5	b827d9da7032bf051756ddf88352af922eb0f87b
ToppCell	368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	PARP4 HSD17B6 METTL16 MFN1 SCAI	3.88e-05	187	90	5	61c00604dda8b36a5c3eea6554e5601aa1b884f7
ToppCell	normal_Lung-Myeloid_cells-pDCs\|normal_Lung / Location, Cell class and cell subclass	ZNF26 HYOU1 PDE1B SEMA5A ABCB4	3.88e-05	187	90	5	d36751372fd40a46441f07735c9c3c5dcb503f24
ToppCell	facs-Lung-EPCAM-18m-Epithelial-Basal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GALT2 FAT2 PAPLN ADAM28 FAM83B	4.08e-05	189	90	5	783c1db856f2defe6f3b8748dd0bc29a8102f6d1
ToppCell	facs-Lung-EPCAM-18m-Epithelial-respiratory_basal_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GALT2 FAT2 PAPLN ADAM28 FAM83B	4.08e-05	189	90	5	88b72fafbe58463543e0818f27f3dd9e5b4d34d2
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SULT2B1 HSD17B6 SEMA5A PHLDB2 SCAI	4.29e-05	191	90	5	a15e34ad7dbf3f2f13d5e23ce3ffb6d08fd1f9f0
ToppCell	Control-NK_CD56bright\|Control / Disease condition and Cell class	FLNB DST UGGT2 TEC ADAM28	4.51e-05	193	90	5	8b1e7a226a6057e1097c1525984127b54e823876
ToppCell	BL-critical-LOC-Epithelial-Basal\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FAT2 DST SULT2B1 SEMA5A FAM83B	4.62e-05	194	90	5	2932f704656ca368565ec12f3452af3b18e8df12
ToppCell	COVID-19-Myeloid-Monocyte-derived_macrophages\|COVID-19 / group, cell type (main and fine annotations)	MYO9B TRPS1 GSAP TEC GAB2	4.74e-05	195	90	5	c172c5599379c29123340621a36bfb1fc90c2115
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DST SULT2B1 SEMA5A PHLDB2 SCAI	4.74e-05	195	90	5	a71ba5e4043e2d35a45a2c60a96b087e31832345
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FAT2 GATM SEMA5A ADAM28 FAM83B	4.74e-05	195	90	5	6c9c58322c1df891bb4bab56dacb542c8777bb7d
ToppCell	normal_Lung-Epithelial_cells-AT1\|normal_Lung / Location, Cell class and cell subclass	SULT2B1 HSD17B6 RDX SEMA5A SCAI	4.74e-05	195	90	5	569d1ebc5a5aa110a2430b096755ae35354040c4
ToppCell	RA-02._Fibroblast_II\|RA / Chamber and Cluster_Paper	PDE1A TRPS1 UGGT2 ABTB2 GAB2	4.74e-05	195	90	5	6a02ebbeb3199447ddce64d92d8809436e040eba
ToppCell	Mild/Remission-Plasmablast\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	DENND1B HYOU1 LMAN1 INPP4A EDEM1	4.74e-05	195	90	5	52bdd609253613b7db75dccbc1c01c05e8d73f79
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A DENND1B TRPS1 RERE ABTB2	4.85e-05	196	90	5	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB GATM SHE PHLDB2 JAM2	4.97e-05	197	90	5	deefb492b5f0e6014144bd465c4a6ae4206e8739
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLNB FAT2 SULT2B1 TMPRSS11A FAM83B	4.97e-05	197	90	5	fb272c9c60ee3d980e528044dc567b4925a23da6
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DST SULT2B1 HSD17B6 SEMA5A PHLDB2	4.97e-05	197	90	5	c9c968e223e7814cd8d22975d849a31b7e0af7aa
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB GATM SHE PHLDB2 JAM2	4.97e-05	197	90	5	a6aaa6faea348291023f0bc4b0f83fbc67d91da6
ToppCell	COVID-19-kidney-Macrophages\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYO9B TRPS1 GSAP LCP1 ADAM28	4.97e-05	197	90	5	3912301018d0863144dcfac8d1fa8adc081748d7
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLNB FAT2 SULT2B1 TMPRSS11A FAM83B	4.97e-05	197	90	5	61c0d78b29dc4ad8a84172cbfcdab03f31351d0e
ToppCell	AT1_cells-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	FLNB DST SULT2B1 SEMA5A PHLDB2	4.97e-05	197	90	5	80d81be244c94c435accb643449b4ce6a3462c7f
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLNB FAT2 SULT2B1 TMPRSS11A FAM83B	4.97e-05	197	90	5	dcabea5c50c133c9a4e294e447462d0393174ea7
ToppCell	normal_Lung-Epithelial_cells-AT1\|Epithelial_cells / Location, Cell class and cell subclass	DST RDX SEMA5A PHLDB2 SCAI	4.97e-05	197	90	5	7d19b93d6853828e2a036e37c4887edb1de4503c
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DST SULT2B1 HSD17B6 SEMA5A PHLDB2	4.97e-05	197	90	5	e344455e62b3fe94bb242dc0db58d19a1d3878c7
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DCHS2 FAT2 SULT2B1 CDH8 ADAM28	5.09e-05	198	90	5	28ada093cec552262731194a04a4b9ff93186c3b
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB GATM SHE PHLDB2 JAM2	5.09e-05	198	90	5	f0f1816a0ed3ae8207442602f5cbe4de0382e4b3
ToppCell	ASK428-Epithelial-Type_1\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	DST SULT2B1 RDX SEMA5A PHLDB2	5.09e-05	198	90	5	0047a9ef7684230ac5179efea94461480e90bdaf
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PDE1A PAPLN GAB2 PHLDB2 JAM2	5.22e-05	199	90	5	9c2db0bb94cba71a3cc1827844da090e213e0258
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAT2 DST CMYA5 ADAM28 FAM83B	5.22e-05	199	90	5	c88a28a73f54dc571f2ff1e4b55073f83cbead2c
ToppCell	control-Epithelial-Secretory\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FLNB FAT2 CPD CMYA5 ADAM28	5.22e-05	199	90	5	3d01f90ffd271ca00129192787e4921bdca7e01e
ToppCell	control-Epithelial-Secretory\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FLNB FAT2 CPD CMYA5 ADAM28	5.22e-05	199	90	5	262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCell	proximal-Epithelial-Alveolar_Epithelial_Type_1-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SULT2B1 HSD17B6 RDX SEMA5A PHLDB2	5.34e-05	200	90	5	b652bc73adfdeccbdcd74497ab6e2085e5c95e88
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Vein\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	FLNB DST CPD ABCB4 JAM2	5.34e-05	200	90	5	7eb366b2c5394af7c77650bde6261e7dac67154e
ToppCell	proximal-Epithelial-Alveolar_Epithelial_Type_1\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SULT2B1 HSD17B6 RDX SEMA5A PHLDB2	5.34e-05	200	90	5	c1345893e6947ccf9b41282d0e4428dbfb8bcc27
ToppCell	proximal-3-Epithelial-Alveolar_Epithelial_Type_1\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SULT2B1 HSD17B6 RDX SEMA5A PHLDB2	5.34e-05	200	90	5	51f8fc43c069f2c4e75588d28ae6deb5d7ed2c86
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FAT2 NWD1 SEMA5A ADAM28 FAM83B	5.34e-05	200	90	5	8827653738a931e4a4545e0c7d75be12bed40740
ToppCell	Biopsy_Control_(H.)-Epithelial-AT1\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	DST SULT2B1 HSD17B6 SEMA5A PHLDB2	5.34e-05	200	90	5	3a9633f5913f12b6865fc777c84f3f3ba795a78d
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lhx6\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DCHS2 TRPS1 SEMA5A ADAM28	1.03e-04	120	90	4	a4e3f9a83bc52ccc75bcd64b1be4e2c5441f6d1a
ToppCell	Globus_pallidus\|World / BrainAtlas - Mouse McCarroll V32	DCHS2 MYO9B MROH7 UNK	1.24e-04	126	90	4	44b63f945d5bedf1a2ca1810e7e100276ea9dd89
ToppCell	LPS-antiTNF-Hematopoietic_Mast-Mast_cells-Mast-cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	B3GALT2 DHDH GAB3 CPA3	2.08e-04	144	90	4	013223bb2f31eb5bebdbd0908b797d28b96c6f7b
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-NP-L5_NP_VISp_Trhr_Cpne7\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SPAG16 LCP1 PHLDB2 SCAI	2.37e-04	149	90	4	8638b3819193d11411df58964069fec583f617f4
ToppCell	Dendritic_Cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	FLNB GAB3 ADAM28 ABCB4	2.49e-04	151	90	4	e089bf197ed60e7243160521d4390d4b40a3832b
ToppCell	Adult-Epithelial-basal_cell-D122\|Adult / Lineage, Cell type, age group and donor	FAT2 NWD1 CMYA5 FAM83B	2.68e-04	154	90	4	38d346402417960044ae999e61f0092b46f2b591
ToppCell	E16.5-Immune-Immune_Myeloid-Granulocytic\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CPA3 TEC LCP1 ABCB4	2.75e-04	155	90	4	c648512305166d2a2f0e284c127bc802af908071
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_CT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	B3GALT2 PDE1A SEMA5A CMYA5	2.82e-04	156	90	4	fe383ce3a0c37f7343d7026cb51260a04d4c2829
ToppCell	E16.5-samps-Myeloid\|E16.5-samps / Age Group, Lineage, Cell class and subclass	GVINP1 GATM LCP1 TEC	2.82e-04	156	90	4	c7c73cef5700b0ae75280e62c94728434c712537
ToppCell	droplet-Heart-nan-3m-Endothelial-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRED2 SHE PAPLN JAM2	2.89e-04	157	90	4	d85a2f56ae313baa9738e81d2756ce1fe1ba50db
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Fibroblasts\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	B3GALT2 DHDH CEP41 ABTB2	2.89e-04	157	90	4	f086753b51860e23f1275bd75e8802d2a7d7b70a
ToppCell	Control-B_naive-12\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	DST ZNF512 MFN1 MYBL1	2.89e-04	157	90	4	4803f601c1ba43260aa09172acc7964aac2c8ccf
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Club\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	ATP7B SULT2B1 ADAM28 FAM83B	2.96e-04	158	90	4	03281e87780e3bacd089903383c016d03c373bf7
ToppCell	21-Trachea-Epithelial-Submucosal_gland_basal\|Trachea / Age, Tissue, Lineage and Cell class	FZD1 DCHS2 ETV4 ABTB2	3.03e-04	159	90	4	4f670b57b8d3b090ea2f1aafe15baf93cb7ef146
ToppCell	3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAT2 SULT2B1 SEMA5A ADAM28	3.10e-04	160	90	4	445cef1f2f3279672620664792d4eec54df71bdb
ToppCell	mild-Myeloid-Eosinophils\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MYO9B CPA3 TEC ABTB2	3.33e-04	163	90	4	7c57d541a88e9afa079e95b8a6ecdea60a0c6aaa
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	MYO9B GSAP RERE ADAM28	3.33e-04	163	90	4	6bed27d2f67a430a847da5eb47878d14b4949c45
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-NP-L5_NP_VISp_Trhr_Cpne7\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SPAG16 LCP1 PHLDB2	3.53e-04	68	90	3	cdb805182f7169fbc3bec31adec3a4e088281757
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CCDC69 FLNB SHE JAM2	3.57e-04	166	90	4	f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCell	368C-Myeloid-Monocyte-CD16+_Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SULT2B1 INPP4A DHX57 SCAI	3.65e-04	167	90	4	dbd2b9f2f4ba7be5fdf8318094e6b078cb1d1c43
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Diffuse-3\|TCGA-Stomach / Sample_Type by Project: Shred V9	PDE1A GVINP1 GAB3 SHE	3.65e-04	167	90	4	d2230c894ccf9dbba9196e079ae81f384d43da63
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2-Slc17a8.Synpr-Sncg-Yjefn3_(Neuron.Gad1Gad2-Slc17a8.Synpr-Sncg-Yjefn3)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DCHS2 GVINP1 TMPRSS11A	3.69e-04	69	90	3	0862e6c8d8af4310b9a1f0879e51ee25115b26b1
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2-Slc17a8.Synpr-Sncg-Yjefn3_(Neuron.Gad1Gad2-Slc17a8.Synpr-Sncg-Yjefn3)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DCHS2 GVINP1 TMPRSS11A	3.69e-04	69	90	3	d2ff9cea216122d697822cdd2eecbce8f557728d
ToppCell	BAL-Control-cDC_6\|Control / Compartment, Disease Groups and Clusters	ZNF26 RAE1 ABCB4 JAM2	3.73e-04	168	90	4	65ec473cff748b334c0a66e33bc34a8465fe7631
Drug	irinotecan HCl; Down 200; 100uM; MCF7; HT_HG-U133A	GALK2 DENND1B SPRED2 TRPS1 ZHX2 CAMSAP2 MFN1	7.09e-06	183	88	7	7498_DN
Drug	ICI 182,780; Down 200; 1uM; MCF7; HG-U133A	FZD1 DHX57 SEMA5A CPA3 CPD METTL16 MYBL1	9.70e-06	192	88	7	367_DN
Drug	Tranexamic acid [1197-18-8]; Up 200; 25.4uM; PC3; HT_HG-U133A	FZD1 SPRED2 LMAN1 MYO9B INPP4A GLCE WDR1	1.07e-05	195	88	7	2085_UP
Drug	DMEP	DST RERE ABCB4	1.20e-05	12	88	3	CID000008344
Drug	Tyloxapol [25301-02-4]; Down 200; 4uM; HL60; HT_HG-U133A	FLNB GALK2 MYO9B TRPS1 TEC ZHX2 ABCB4	1.22e-05	199	88	7	3074_DN
Disease	tyrosine-protein kinase TEC measurement	TEC TEC	5.14e-05	4	87	2	EFO_0020830
Disease	necrotizing enterocolitis	TRPS1 OTOL1 ADAM28	6.88e-05	27	87	3	EFO_0003928
Disease	isolated growth hormone deficiency type II (implicated_via_orthology)	CSH1 CSH2	8.54e-05	5	87	2	DOID:0060872 (implicated_via_orthology)
Disease	isolated growth hormone deficiency (implicated_via_orthology)	CSH1 CSH2	1.79e-04	7	87	2	DOID:0060870 (implicated_via_orthology)
Disease	cystic fibrosis (implicated_via_orthology)	EDEM1 ABCB4	3.05e-04	9	87	2	DOID:1485 (implicated_via_orthology)
Disease	R-6-hydroxywarfarin measurement	NWD1 GLCE TRPS1 SYT4	3.67e-04	114	87	4	EFO_0803327
Disease	phospholipids in very small VLDL measurement	SULT2B1 TRPS1 LCP1	4.65e-04	51	87	3	EFO_0022300
Disease	Inflammation	ATP7B SULT2B1 WDR1 ABCB4	5.53e-04	127	87	4	C0021368
Disease	smoking status measurement	VRK2 GALK2 DENND1B HSD17B6 SYT4 OTOL1 RERE WDR1 CDH8 GAB2 SCAI	6.01e-04	1160	87	11	EFO_0006527
Disease	congenital hypothyroidism (biomarker_via_orthology)	CSH1 CSH2	7.64e-04	14	87	2	DOID:0050328 (biomarker_via_orthology)
Disease	acute kidney failure (biomarker_via_orthology)	CYP2E1 GATM MFN1	7.87e-04	61	87	3	DOID:3021 (biomarker_via_orthology)
Disease	breast carcinoma (is_marker_for)	FZD1 ATP7B ADAM28	9.91e-04	66	87	3	DOID:3459 (is_marker_for)
Disease	Non-alcoholic Fatty Liver Disease	CYP2E1 RDX ABCB4	1.18e-03	70	87	3	C0400966
Disease	Nonalcoholic Steatohepatitis	CYP2E1 RDX ABCB4	1.18e-03	70	87	3	C3241937
Disease	osteochondrodysplasia (is_implicated_in)	FLNB TRPS1	1.42e-03	19	87	2	DOID:2256 (is_implicated_in)
Disease	cystathionine measurement	TEC TEC	1.42e-03	19	87	2	EFO_0010474
Disease	osteoporosis (biomarker_via_orthology)	CSH1 CSH2	1.91e-03	22	87	2	DOID:11476 (biomarker_via_orthology)
Disease	cortical surface area measurement	FLNB DCHS2 VRK2 DENND1B MYO9B SYT4 SEMA5A CPA3 RERE WDR1 STAT1	1.98e-03	1345	87	11	EFO_0010736
Disease	gout	DST CYP2E1 WDR1 MFN1	2.73e-03	196	87	4	EFO_0004274
Disease	azoospermia (implicated_via_orthology)	NDST3 UBE2R2	2.88e-03	27	87	2	DOID:14227 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QEHALFKYNPDEKNY	ADAM28	151	Q9UKQ2
YKKPDLERYEAQAHG	ATP7B	1376	P35670
GLEHYYPKKLSKANF	GVINP1	866	Q7Z2Y8
PYSNDILEYKNAHGK	CEP41	206	Q9BYV8
QYGLSHYSKNLTEKP	GLCE	216	O94923
LSRNYKKHIQDYGSP	CCDC69	156	A6NI79
PQQSFKQEYHDPLYE	ETV4	221	P43268
SHNGSYVYFPKIGDK	NWD1	1221	Q149M9
KELYESNKHFLGPYN	MROH7	656	Q68CQ1
QLAHKYFELFPDQKD	NDST3	556	O95803
GHEFYNPQKKNYIFL	RAE1	341	P78406
PEHFLNENGKFKYSD	CYP2E1	411	P05181
YAFNSLQLKAFPKHY	INPP4A	951	Q96PE3
IPCKKFDLSYNLNYH	MFN1	496	Q8IWA4
DYNKEIHKPGYLAND	RDX	136	P35241
HRGQPYTYDAKVKNF	RADX	471	Q6NSI4
YDPFKEDLNHLVGYK	NUDT15	146	Q9NV35
FYQKQGGHYFPKDHL	GATM	106	P50440
YEFVAALHPNKDAYK	DST	7256	Q03001
NPDVLEYYRNKHSSK	GAB3	41	Q8WWW8
YIPKDQKYSFLHDSQ	CSH2	61	P0DML3
SKANLDPGNSKHYVY	FAM83B	671	Q5T0W9
GDYSILVKYNDKHIP	FLNB	1886	O75369
FDQEVNHYKGKNYPI	PCYT2	251	Q99447
SKAYYHLLEQVAPKG	LCP1	296	P13796
SLKKPFDYQALNKYH	FAT2	2126	Q9NYQ8
ALEVGYSKYKNPYHN	PDE1A	206	P54750
LETGYGKYKNPYHNQ	PDE1B	211	Q01064
KLPSFLANVHKAYYQ	GALK2	416	Q01415
FEYKYSFKGPHLVQS	LMAN1	46	P49257
AYLASKYPDFKQHVQ	METTL16	21	Q86W50
FALQKHYPAKEQYGD	FBXO25	301	Q8TCJ0
LGYHKAYGFSAPKDQ	JAM2	21	P57087
QFGTGYKELFSYPKH	PARP4	916	Q9UKK3
EKLYGPYRNSVQKAH	ABCB4	921	P21439
ETKFFHSEYPYKQVG	DCHS2	2601	Q6V1P9
PNSYHFKYIINEPEK	B3GALT2	131	O43825
KVPSYLNYHFLGEKD	FZD1	281	Q9UP38
LNSNLEYVKYAKPHF	GSAP	526	A4D1B5
KKGDLLNAHYDGYLA	FKBP7	51	Q9Y680
YPDYESKGIKAHFNL	HYOU1	531	Q9Y4L1
ADQYLLPKDYHNKSV	KDM1B	371	Q8NB78
PKHIKETYGQQYFDA	HSD17B6	231	O14756
VKEDIPGRHSYAKYN	CPA3	106	P15088
EIRFSKDHKYPYQAP	DHX57	356	Q6P158
YVLSEGKKQQEHQPY	CMYA5	2546	Q8N3K9
EVFKYLAKAYASNHP	CPD	286	O75976
NLNGVYYHAPDNKYK	ANGPT4	461	Q9Y264
KYLYLLFDEDNPVHK	EDEM1	556	Q92611
AQKHDIPKAYGSYEE	DHDH	46	Q9UQ10
DLQKYYKSNPGHYLG	IDE	321	P14735
DKDDPKNGHYFLYSL	CDH8	521	P55286
YIPKDQKYSFLHDSQ	CSH1	61	P0DML2
SVQYTPVYKLHNEKG	DENND1B	481	Q6P3S1
LYKYNSDRKQFSHIP	CAMSAP2	1441	Q08AD1
YADHDYEVPQQKGLK	MYBL1	16	P10243
KFEKILYNDQGNYSP	OTOL1	361	A6NHN0
DFQAPYLLHGKYVKE	MICOS10	61	Q5TGZ0
QLDPVSFSNYLKKYH	MEMO1	226	Q9Y316
GDPDVLEYYKNDHSK	GAB2	41	Q9UQC2
EDPKKHNLLQGFYQF	RTEL1	941	Q9NZ71
GLSDPYVKVNLYHAK	SYT4	321	Q9H2B2
QLLYAKKLYDSAFHP	SFXN2	66	Q96NB2
LYHYSKIAGQLKDPG	SULT2B1	156	O00204
YLYPNIDKDHAFGKY	STAT1	666	P42224
KYYLAEKHAFGSIPE	TEC	311	P42680
EHLLKYEYQPFAGKI	WDR1	91	O75083
GHLPSQEDYYSRLKK	RERE	1546	Q9P2R6
EVYYDHLKNANKSPN	PHLDB2	1196	Q86SQ0
ERNKYFNPHLTGKTY	SEMA5A	1046	Q13591
YKYAKIHNAPELALF	ABTB2	956	Q8N961
KDLKHLIYYRFNTGP	PRPF8	606	Q6P2Q9
YYGNDPTDLIKHFRK	TRPS1	231	Q9UHF7
QFDEYQLAKYNPRKH	TEP1	371	Q99973
IPKGENFYYKHREAV	PAPLN	121	O95428
NDLKGLKLHYASYEP	SPAG16	211	Q8N0X2
HIGIKNGYDFYPKAL	TPP2	111	P29144
DAYPHQYSLKLEKGD	TPP2	871	P29144
ENPHKYLLYKPTFSQ	SCAI	331	Q8N9R8
YVRFAKGEVPKHDYN	SPRED2	251	Q7Z698
TYHAYPDFAPQKFKE	ZHX2	521	Q9Y6X8
DKFHGYEEPYFLKHQ	ZNF26	151	P17031
KYNHINAKDDLPGVY	TTC37	86	Q6PGP7
TLYEGGYFKAHIKFP	UBE2R2	51	Q712K3
YLFKGDHKFPTNKEN	UGGT2	166	Q9NYU1
EVVHYYSNEKLPFKG	SHE	466	Q5VZ18
AQPEKPQHYTYLKEF	UNK	26	Q9C0B0
EDYREFPQKKHKLYG	ZNF512	111	Q96ME7
HSLAYDEKPNYQALK	VRK2	296	Q86Y07
QKKEYYHGSFKILDP	TMPRSS11A	46	Q6ZMR5
FKQQHEDNKYFLGTP	MYO9B	611	Q13459