Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	group II metabotropic glutamate receptor activity	GRM2 GRM3	9.80e-06	2	63	2	GO:0001641
GeneOntologyMolecularFunction	hemoglobin alpha binding	HBG1 HBG2	9.74e-05	5	63	2	GO:0031721
GeneOntologyMolecularFunction	retinoic acid-responsive element binding	RXRB RXRG	2.04e-04	7	63	2	GO:0044323
GeneOntologyMolecularFunction	apolipoprotein receptor binding	ABCA12 PCSK9	2.04e-04	7	63	2	GO:0034190
GeneOntologyMolecularFunction	G protein-coupled glutamate receptor activity	GRM2 GRM3	3.48e-04	9	63	2	GO:0098988
GeneOntologyMolecularFunction	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	GRM2 GRM3	3.48e-04	9	63	2	GO:0001640
GeneOntologyMolecularFunction	haptoglobin binding	HBG1 HBG2	4.34e-04	10	63	2	GO:0031720
GeneOntologyMolecularFunction	hemoglobin binding	HBG1 HBG2	5.29e-04	11	63	2	GO:0030492
GeneOntologyMolecularFunction	oxygen carrier activity	HBG1 HBG2	8.70e-04	14	63	2	GO:0005344
GeneOntologyMolecularFunction	Wnt receptor activity	LRP6 NID1	1.29e-03	17	63	2	GO:0042813
GeneOntologyMolecularFunction	ion channel regulator activity	KCNK2 GRM2 GRM3 PCSK9	1.71e-03	162	63	4	GO:0099106
GeneOntologyMolecularFunction	apolipoprotein binding	LRP6 PCSK9	1.79e-03	20	63	2	GO:0034185
GeneOntologyMolecularFunction	K48-linked deubiquitinase activity	USP9X USP7	1.98e-03	21	63	2	GO:1990380
GeneOntologyMolecularFunction	channel regulator activity	KCNK2 GRM2 GRM3 PCSK9	2.22e-03	174	63	4	GO:0016247
GeneOntologyMolecularFunction	transporter regulator activity	KCNK2 GRM2 GRM3 PCSK9	2.37e-03	177	63	4	GO:0141108
GeneOntologyMolecularFunction	nuclear steroid receptor activity	RXRB RXRG	2.80e-03	25	63	2	GO:0003707
GeneOntologyMolecularFunction	glutamate receptor activity	GRM2 GRM3	3.27e-03	27	63	2	GO:0008066
GeneOntologyMolecularFunction	mannosyltransferase activity	TMTC1 DPY19L1	3.51e-03	28	63	2	GO:0000030
GeneOntologyCellularComponent	astrocyte projection	KCNK2 GRM2 GRM3	6.00e-05	25	64	3	GO:0097449
GeneOntologyCellularComponent	glial cell projection	KCNK2 GRM2 GRM3	4.03e-04	47	64	3	GO:0097386
GeneOntologyCellularComponent	haptoglobin-hemoglobin complex	HBG1 HBG2	5.97e-04	12	64	2	GO:0031838
GeneOntologyCellularComponent	hemoglobin complex	HBG1 HBG2	5.97e-04	12	64	2	GO:0005833
Domain	Haemoglobin_b	HBG1 HBG2	1.08e-04	5	62	2	IPR002337
Domain	GPCR_3_mtglu_rcpt	GRM2 GRM3	3.00e-04	8	62	2	IPR000162
Domain	Retinoid-X_rcpt/HNF4	RXRB RXRG	4.80e-04	10	62	2	IPR000003
Domain	Globin	HBG1 HBG2	7.00e-04	12	62	2	IPR000971
Domain	MATH/TRAF_dom	MEP1A USP7	7.00e-04	12	62	2	IPR002083
Domain	MATH	MEP1A USP7	7.00e-04	12	62	2	PS50144
Domain	Globin	HBG1 HBG2	7.00e-04	12	62	2	PF00042
Domain	MATH	MEP1A USP7	7.00e-04	12	62	2	SM00061
Domain	MATH	MEP1A USP7	7.00e-04	12	62	2	PF00917
Domain	GLOBIN	HBG1 HBG2	7.00e-04	12	62	2	PS01033
Domain	NCD3G	GRM2 GRM3	8.26e-04	13	62	2	PF07562
Domain	GPCR_3_9-Cys_dom	GRM2 GRM3	8.26e-04	13	62	2	IPR011500
Domain	-	HBG1 HBG2	8.26e-04	13	62	2	1.10.490.10
Domain	Globin/Proto	HBG1 HBG2	8.26e-04	13	62	2	IPR012292
Domain	Ldl_recept_b	LRP6 NID1	9.62e-04	14	62	2	PF00058
Domain	LDLRB	LRP6 NID1	9.62e-04	14	62	2	PS51120
Domain	GPCR_3_CS	GRM2 GRM3	9.62e-04	14	62	2	IPR017979
Domain	LY	LRP6 NID1	1.11e-03	15	62	2	SM00135
Domain	LDLR_classB_rpt	LRP6 NID1	1.11e-03	15	62	2	IPR000033
Domain	Globin-like	HBG1 HBG2	1.26e-03	16	62	2	IPR009050
Domain	Acyltransferase	GPAM TMEM68	1.26e-03	16	62	2	PF01553
Domain	PlsC	GPAM TMEM68	1.43e-03	17	62	2	SM00563
Domain	Plipid/glycerol_acylTrfase	GPAM TMEM68	1.43e-03	17	62	2	IPR002123
Domain	GPCR_3	GRM2 GRM3	2.19e-03	21	62	2	IPR000337
Domain	7tm_3	GRM2 GRM3	2.40e-03	22	62	2	PF00003
Domain	G_PROTEIN_RECEP_F3_2	GRM2 GRM3	2.40e-03	22	62	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GRM2 GRM3	2.40e-03	22	62	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GRM2 GRM3	2.40e-03	22	62	2	PS00979
Domain	G_PROTEIN_RECEP_F3_4	GRM2 GRM3	2.40e-03	22	62	2	PS50259
Domain	GPCR_3_C	GRM2 GRM3	2.40e-03	22	62	2	IPR017978
Domain	TRAF-like	MEP1A USP7	2.85e-03	24	62	2	IPR008974
Pathway	KEGG_MEDICUS_VARIANT_PAX8_PPARG_FUSION_TO_PPARG_MEDIATED_TRANSCRIPTION	RXRB RXRG	1.04e-04	5	46	2	M49023
Pathway	PID_RETINOIC_ACID_PATHWAY	EP300 RXRB RXRG	1.24e-04	30	46	3	M207
Pathway	WP_VITAMIN_A1_AND_A5X_PATHWAYS	RXRB RXRG	1.55e-04	6	46	2	M48097
Pathway	REACTOME_NFE2L2_REGULATES_PENTOSE_PHOSPHATE_PATHWAY_GENES	TKT EP300	2.88e-04	8	46	2	M46443
Pubmed	Selective silencing of individual dendritic branches by an mGlu2-activated potassium conductance in dentate gyrus granule cells.	GRM2 GRM3	3.33e-06	2	64	2	23616537
Pubmed	Activation of metabotropic glutamate receptor type 2/3 supports the involvement of the hippocampal mossy fiber pathway on contextual fear memory consolidation.	GRM2 GRM3	3.33e-06	2	64	2	19638469
Pubmed	Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.	GRM2 GRM3	3.33e-06	2	64	2	21628565
Pubmed	Group II metabotropic glutamate receptor blockade promotes stress resilience in mice.	GRM2 GRM3	3.33e-06	2	64	2	30939596
Pubmed	A new (G)γ-globin variant causing low oxygen affinity: Hb F-Brugine/Feldkirch [(G)γ105(G7)Leu→His; HBG2: c.317T>A].	HBG1 HBG2	3.33e-06	2	64	2	24502349
Pubmed	Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice.	GRM2 GRM3	3.33e-06	2	64	2	24053122
Pubmed	Cigarette smoke extract mediates cell premature senescence in chronic obstructive pulmonary disease patients by up-regulating USP7 to activate p300-p53/p21 pathway.	USP7 EP300	3.33e-06	2	64	2	35114313
Pubmed	The relationship between the variations in Gγ and Aγ promotors and the Hereditary Persistence of Fetal Hemoglobin (HPFH).	HBG1 HBG2	3.33e-06	2	64	2	29412791
Pubmed	Two novel arrangements of the human fetal globin genes: G gamma-G gamma and A gamma-A gamma.	HBG1 HBG2	3.33e-06	2	64	2	6091051
Pubmed	Oligomerization and ligand binding in a homotetrameric hemoglobin: two high-resolution crystal structures of hemoglobin Bart's (gamma(4)), a marker for alpha-thalassemia.	HBG1 HBG2	3.33e-06	2	64	2	11514664
Pubmed	Adaptive Changes in Group 2 Metabotropic Glutamate Receptors Underlie the Deficit in Recognition Memory Induced by Methamphetamine in Mice.	GRM2 GRM3	3.33e-06	2	64	2	38969501
Pubmed	An embryonic stage-specific enhancer within the murine β-globin locus mediates domain-wide histone hyperacetylation.	HBG1 HBG2	3.33e-06	2	64	2	21321362
Pubmed	Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction.	GRM2 GRM3	3.33e-06	2	64	2	25583490
Pubmed	The mGluR2/3 agonist LY379268 induced anti-reinstatement effects in rats exhibiting addiction-like behavior.	GRM2 GRM3	3.33e-06	2	64	2	23624743
Pubmed	The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection.	GRM2 GRM3	3.33e-06	2	64	2	17670976
Pubmed	Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light.	GRM2 GRM3	3.33e-06	2	64	2	25950516
Pubmed	The effect of mGlu2/3 receptors on synaptic activities to different types of GABAergic interneurons in the anterior cingulate cortex.	GRM2 GRM3	3.33e-06	2	64	2	32525061
Pubmed	A study on the genotype frequency of -158 Gγ (C→T) Xmn1 polymorphism in a sickle cell trait cohort from Siwa Oasis, Egypt.	HBG1 HBG2	3.33e-06	2	64	2	29932071
Pubmed	Association analysis of group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population.	GRM2 GRM3	3.33e-06	2	64	2	19386277
Pubmed	Mechanism for fetal globin gene expression: role of the soluble guanylate cyclase-cGMP-dependent protein kinase pathway.	HBG1 HBG2	3.33e-06	2	64	2	11172039
Pubmed	Expression and subcellular distribution of glutamate receptor subunits 2/3 in the developing cerebellar cortex.	GRM2 GRM3	3.33e-06	2	64	2	8838577
Pubmed	The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells.	GRM2 GRM3	3.33e-06	2	64	2	7965099
Pubmed	Metabotropic Glutamate Receptor 2/3 Activation Improves Motor Performance and Reduces Pathology in Heterozygous zQ175 Huntington Disease Mice.	GRM2 GRM3	3.33e-06	2	64	2	34330748
Pubmed	Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis.	GRM2 GRM3	3.33e-06	2	64	2	25434487
Pubmed	Ubiquitin-specific protease 9X in host cells interacts with herpes simplex virus 1 ICP0.	USP9X USP7	3.33e-06	2	64	2	26596467
Pubmed	NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer's, and Ethanol Intoxication.	GRM2 GRM3	3.33e-06	2	64	2	28285415
Pubmed	Promoter region sequence differences in the A and G gamma globin genes of Brazilian sickle cell anemia patients.	HBG1 HBG2	3.33e-06	2	64	2	20602015
Pubmed	Sequences of G gamma, A gamma, and beta genes of the Greek (A gamma) HPFH mutant: evidence for a distal CCAAT box mutation in the A gamma gene.	HBG1 HBG2	3.33e-06	2	64	2	2413469
Pubmed	Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: the metabotropic pathway.	GRM2 GRM3	3.33e-06	2	64	2	24080311
Pubmed	mGlu2/3 receptor in the prelimbic cortex is implicated in stress resilience and vulnerability in mice.	GRM2 GRM3	3.33e-06	2	64	2	34090896
Pubmed	Two mouse early embryonic beta-globin gene sequences. Evolution of the nonadult beta-globins.	HBG1 HBG2	3.33e-06	2	64	2	6323438
Pubmed	Human fetal hemoglobin F 1. Acetylation status.	HBG1 HBG2	3.33e-06	2	64	2	5554303
Pubmed	G gamma-196 C-->T, A gamma-201 C-->T: two novel mutations in the promoter region of the gamma-globin genes associated with nondeletional hereditary persistence of fetal hemoglobin in Greece.	HBG1 HBG2	3.33e-06	2	64	2	18096417
Pubmed	Effect of HIV type 1 Tat protein on butyric acid-induced differentiation in a hematopoietic progenitor cell line.	HBG1 HBG2	3.33e-06	2	64	2	8911578
Pubmed	Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice.	GRM2 GRM3	3.33e-06	2	64	2	22089319
Pubmed	Hb F-Charlotte, an A gamma variant with a threonine residue in position gamma 75 and a glycine residue in position gamma 136.	HBG1 HBG2	3.33e-06	2	64	2	1714434
Pubmed	Regulation of cocaine-induced reinstatement by group II metabotropic glutamate receptors in the ventral tegmental area.	GRM2 GRM3	3.33e-06	2	64	2	21881873
Pubmed	Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development.	RXRB RXRG	3.33e-06	2	64	2	9150186
Pubmed	Fractionation of spatial memory in GRM2/3 (mGlu2/mGlu3) double knockout mice reveals a role for group II metabotropic glutamate receptors at the interface between arousal and cognition.	GRM2 GRM3	3.33e-06	2	64	2	21832989
Pubmed	Retinoid x receptor gamma control of affective behaviors involves dopaminergic signaling in mice.	RXRB RXRG	3.33e-06	2	64	2	20620876
Pubmed	HbF-Lesvos: an HbF variant due to a novel G gamma mutation (:G gamma 75 ATA-->ACA) detected in a Greek family.	HBG1 HBG2	3.33e-06	2	64	2	8566966
Pubmed	The role of group II metabotropic glutamate receptors in cognition and anxiety: comparative studies in GRM2(-/-), GRM3(-/-) and GRM2/3(-/-) knockout mice.	GRM2 GRM3	3.33e-06	2	64	2	25158312
Pubmed	A novel C-T transition within the distal CCAAT motif of the G gamma-globin gene in the Japanese HPFH: implication of factor binding in elevated fetal globin expression.	HBG1 HBG2	3.33e-06	2	64	2	1698280
Pubmed	Activation of Group II Metabotropic Glutamate Receptors Promotes LTP Induction at Schaffer Collateral-CA1 Pyramidal Cell Synapses by Priming NMDA Receptors.	GRM2 GRM3	3.33e-06	2	64	2	27911756
Pubmed	A history of the human fetal globin gene duplication.	HBG1 HBG2	3.33e-06	2	64	2	7332928
Pubmed	The Greek A gamma beta+-HPFH observed in a large black family.	HBG1 HBG2	3.33e-06	2	64	2	2441598
Pubmed	Reduction of group II metabotropic glutamate receptors during development of benzodiazepine dependence.	GRM2 GRM3	3.33e-06	2	64	2	23392308
Pubmed	Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice.	GRM2 GRM3	3.33e-06	2	64	2	20970439
Pubmed	Altered hippocampal expression of glutamate receptors and transporters in GRM2 and GRM3 knockout mice.	GRM2 GRM3	3.33e-06	2	64	2	18720515
Pubmed	Human fetal G gamma- and A gamma-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes.	HBG1 HBG2	3.33e-06	2	64	2	7438203
Pubmed	Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice.	GRM2 GRM3	3.33e-06	2	64	2	34217776
Pubmed	Metabotropic glutamate receptor 2/3 in the hippocampus of patients with mesial temporal lobe epilepsy, and of rats and mice after pilocarpine-induced status epilepticus.	GRM2 GRM3	3.33e-06	2	64	2	15246118
Pubmed	Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia.	GRM2 GRM3	3.33e-06	2	64	2	18853337
Pubmed	High levels of human gamma-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin.	HBG1 HBG2	3.33e-06	2	64	2	9121456
Pubmed	Memantine-induced brain activation as a model for the rapid screening of potential novel antipsychotic compounds: exemplified by activity of an mGlu2/3 receptor agonist.	GRM2 GRM3	3.33e-06	2	64	2	21057775
Pubmed	Hippocampal mossy fiber long-term depression in Grm2/3 double knockout mice.	GRM2 GRM3	3.33e-06	2	64	2	21360593
Pubmed	Transcriptional factors p300 and MRTF-A synergistically enhance the expression of migration-related genes in MCF-7 breast cancer cells.	EP300 MRTFA	3.33e-06	2	64	2	26476216
Pubmed	Developmental expression of mGlu2 and mGlu3 in the mouse brain.	GRM2 GRM3	3.33e-06	2	64	2	27818290
Pubmed	Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling.	EP300 RXRB RXRG	3.97e-06	17	64	3	28291835
Pubmed	Cooperative formation of high-order oligomers by retinoid X receptors: an unexpected mode of DNA recognition.	RXRB RXRG	9.99e-06	3	64	2	7831303
Pubmed	The chloride effect in the human embryonic haemoglobins.	HBG1 HBG2	9.99e-06	3	64	2	7543751
Pubmed	TEA domain transcription factor 4 modulates repression of fetal haemoglobin by direct binding to the γ-globin gene promoters.	HBG1 HBG2	9.99e-06	3	64	2	34569056
Pubmed	Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.	GRM2 GRM3	9.99e-06	3	64	2	34620856
Pubmed	Pharmacogenetic analysis of the mGlu2/3 agonist LY2140023 monohydrate in the treatment of schizophrenia.	GRM2 GRM3	9.99e-06	3	64	2	21173788
Pubmed	Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics.	GRM2 GRM3	9.99e-06	3	64	2	24949866
Pubmed	Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.	RXRB RXRG	9.99e-06	3	64	2	1312497
Pubmed	Detection of retinoid X receptors using specific monoclonal and polyclonal antibodies.	RXRB RXRG	9.99e-06	3	64	2	7980510
Pubmed	Differential segregation of beta+ IVS-I-110 (G --> A), A(gamma) -117 (G-->A), and G(gamma) -158 (C --> T) mutations in members of an Albanian family.	HBG1 HBG2	9.99e-06	3	64	2	14649320
Pubmed	Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate.	RXRB RXRG	9.99e-06	3	64	2	12514092
Pubmed	Histone acetyltransferase p300 promotes MRTF-A-mediates transactivation of VE-cadherin gene in human umbilical vein endothelial cells.	EP300 MRTFA	9.99e-06	3	64	2	25746323
Pubmed	Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects.	RXRB RXRG	9.99e-06	3	64	2	11053444
Pubmed	Impaired locomotion and dopamine signaling in retinoid receptor mutant mice.	RXRB RXRG	9.99e-06	3	64	2	9452386
Pubmed	Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin.	HBG1 HBG2	9.99e-06	3	64	2	34341563
Pubmed	Histone acetyltransferase p300 promotes MKL1-mediated transactivation of catechol-O-methyltransferase gene.	EP300 MRTFA	9.99e-06	3	64	2	24096006
Pubmed	Retinoid X receptors: X-ploring their (patho)physiological functions.	RXRB RXRG	9.99e-06	3	64	2	15608692
Pubmed	Chromosomal localization of the human retinoid X receptors.	RXRB RXRG	9.99e-06	3	64	2	8034312
Pubmed	Gene transfer to pre-hematopoietic and committed hematopoietic precursors in the early mouse yolk sac: a comparative study between in situ electroporation and retroviral transduction.	HBG1 HBG2	9.99e-06	3	64	2	17605779
Pubmed	Histone hyperacetylation within the beta-globin locus is context-dependent and precedes high-level gene expression.	HBG1 HBG2	9.99e-06	3	64	2	19690338
Pubmed	Retinoid receptors trigger neuritogenesis in retinal degenerations.	RXRB RXRG	9.99e-06	3	64	2	21940995
Pubmed	Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1 synapses.	GRM2 GRM3	9.99e-06	3	64	2	38864289
Pubmed	The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer.	RXRB RXRG	9.99e-06	3	64	2	11839661
Pubmed	Evaluation of 5-HT2A and mGlu2/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: effect of antidepressant treatment.	GRM2 GRM3	9.99e-06	3	64	2	25150943
Pubmed	Promoters of the murine embryonic beta-like globin genes Ey and betah1 do not compete for interaction with the beta-globin locus control region.	HBG1 HBG2	9.99e-06	3	64	2	12525692
Pubmed	An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression.	RXRB RXRG	9.99e-06	3	64	2	9883728
Pubmed	mGlu2 and mGlu3 Negative Allosteric Modulators Divergently Enhance Thalamocortical Transmission and Exert Rapid Antidepressant-like Effects.	GRM2 GRM3	9.99e-06	3	64	2	31735403
Pubmed	RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.	RXRB RXRG	9.99e-06	3	64	2	8799145
Pubmed	LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells.	HBG1 HBG2	9.99e-06	3	64	2	8661146
Pubmed	Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I.	HBG1 HBG2	2.00e-05	4	64	2	7512369
Pubmed	Group II metabotropic glutamate receptor interactions with NHERF scaffold proteins: Implications for receptor localization in brain.	GRM2 GRM3	2.00e-05	4	64	2	28392297
Pubmed	Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system.	GRM2 GRM3	2.00e-05	4	64	2	29079293
Pubmed	Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.	RXRB RXRG	2.00e-05	4	64	2	1310259
Pubmed	Inhibition of presynaptic calcium transients in cortical inputs to the dorsolateral striatum by metabotropic GABA(B) and mGlu2/3 receptors.	GRM2 GRM3	2.00e-05	4	64	2	25781000
Pubmed	Retinoic acid biosynthetic activity and retinoid receptors in the olfactory mucosa of adult mice.	RXRB RXRG	2.00e-05	4	64	2	10079186
Pubmed	The mouse globin pseudogene beta h3 is descended from a premammalian delta-globin gene.	HBG1 HBG2	2.00e-05	4	64	2	6092350
Pubmed	Novel variants in Krueppel like factor 1 that cause persistence of fetal hemoglobin in In(Lu) individuals.	HBG1 HBG2	2.00e-05	4	64	2	34535703
Pubmed	Induction of zinc finger protein RNF6 auto-ubiquitination for the treatment of myeloma and chronic myeloid leukemia.	USP9X USP7	2.00e-05	4	64	2	35926709
Pubmed	Pregnane X Receptor Expression in Human Pancreatic Adenocarcinoma: Associations With Clinicopathologic Parameters, Tumor Proliferative Capacity, Patients' Survival, and Retinoid X Receptor Expression.	RXRB RXRG	2.00e-05	4	64	2	26355550
Pubmed	Embryonic hemoglobins in man and other mammals.	HBG1 HBG2	2.00e-05	4	64	2	7008862
Pubmed	Retinoids activate RXR/CAR-mediated pathway and induce CYP3A.	RXRB RXRG	2.00e-05	4	64	2	19686701
Pubmed	Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors.	RXRB RXRG	2.00e-05	4	64	2	33692389
Cytoband	8q12.1	TMEM68 CA8	7.58e-04	29	64	2	8q12.1
GeneFamily	Glutamate metabotropic receptors\|Protein phosphatase 1 regulatory subunits	GRM2 GRM3	1.33e-04	8	40	2	281
GeneFamily	Hemoglobin subunits	HBG1 HBG2	2.12e-04	10	40	2	940
GeneFamily	Nuclear hormone receptors	RXRB RXRG	5.26e-03	49	40	2	71
GeneFamily	Ubiquitin specific peptidases	USP9X USP7	6.82e-03	56	40	2	366
Coexpression	GSE3982_MAST_CELL_VS_CENT_MEMORY_CD4_TCELL_UP	TMEM53 DPY19L1 TKT TMEM70 XPNPEP1 DOCK6	7.67e-06	199	62	6	M5446
ToppCell	wk_20-22-Hematologic-Meg-ery-Definitive_erythroblast\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	USP7 HBG1 HBG2 EP300 CA8	6.44e-06	182	64	5	0c77ef4556c1d1512ebe9077df858b28f9e38dd5
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FRYL FER1L6 PCSK9 CFAP65 CA8	9.00e-06	195	64	5	7ff04c45a02df01e3816f3c1d43585a93182a730
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-goblet\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FRYL FER1L6 PCSK9 CFAP65 CA8	9.00e-06	195	64	5	09605533aa5947bb2e5a6725c1ce89f79d330bf5
Drug	PCMB	GBA3 CLIP2 TKT XPNPEP1 CYB561A3 HBG1 HBG2	6.77e-07	178	64	7	CID000001730
Drug	Gm(5')ppp	GFM1 HBG1 HBG2	1.16e-05	16	64	3	CID000173813
Drug	Levopropoxyphene napsylate [5714-90-9]; Up 200; 7.4uM; PC3; HT_HG-U133A	ZNF93 PLBD1 SLC16A4 GLP1R GRM2 CA8	1.92e-05	197	64	6	5083_UP
Drug	Bexarotene	RXRB RXRG	2.33e-05	3	64	2	DB00307
Drug	2-hydroxyphytanic acid	RXRB RXRG	2.33e-05	3	64	2	ctd:C002585
Drug	AC1O5SBP	RXRB RXRG	2.33e-05	3	64	2	CID006439746
Drug	LY 379268	GRM2 GRM3	2.33e-05	3	64	2	ctd:C118218
Drug	isospaglumic acid	GRM2 GRM3	2.33e-05	3	64	2	ctd:C027172
Drug	AGN 190727	RXRB RXRG	4.65e-05	4	64	2	CID006439768
Drug	N-phenylglycolhydroxamate	GBA3 TKT	4.65e-05	4	64	2	CID000115251
Drug	LY 341495	GRM2 GRM3	4.65e-05	4	64	2	ctd:C114624
Drug	7-methoxycitronellal	RXRB RXRG	7.74e-05	5	64	2	CID000019223
Drug	7-methoxycitronellic acid	RXRB RXRG	7.74e-05	5	64	2	CID000171516
Drug	13,14-dihydroretinol	RXRB RXRG	7.74e-05	5	64	2	CID000446798
Drug	Acamprosate	GRM2 GRM3	7.74e-05	5	64	2	DB00659
Drug	T0901317	GPAM RXRB RXRG PCSK9	8.03e-05	81	64	4	CID000447912
Drug	TG-3	TGM6 GRM2 GRM3	1.09e-04	33	64	3	CID000205489
Drug	troglitazone	LAD1 LRP6 GPAM HBG1 HBG2 EP300 RXRB RXRG	1.09e-04	526	64	8	CID000005591
Drug	cobalt-60	GBA3 LAMA3 XPNPEP1 GRM3 CYB561A3 HBG1 HBG2	1.10e-04	390	64	7	CID000061492
Drug	Alitretinoin	RXRB RXRG	1.16e-04	6	64	2	DB00523
Drug	Adapalene	RXRB RXRG	1.16e-04	6	64	2	DB00210
Drug	triphenyltin hydroxide	RXRB RXRG	1.16e-04	6	64	2	ctd:C007567
Drug	Etretinate	RXRB RXRG	1.16e-04	6	64	2	DB00926
Drug	aurintricarboxylic acid	STAG1 GRM2 GRM3 ENDOG	1.26e-04	91	64	4	CID000002259
Drug	DR-0	TKT RXRB RXRG	1.30e-04	35	64	3	CID010062716
Drug	Acitretin	RXRB RXRG	1.62e-04	7	64	2	DB00459
Drug	AGN 191659	RXRB RXRG	1.62e-04	7	64	2	CID006366726
Drug	azetidine-2,4-dicarboxylic acid	GRM2 GRM3	1.62e-04	7	64	2	CID000005370
Drug	AGN 190121	RXRB RXRG	1.62e-04	7	64	2	CID006441236
Drug	indigo dye	GBA3 ABCA12 TKT	1.94e-04	40	64	3	CID005318432
Drug	Rimexolone [49697-38-3]; Up 200; 10.8uM; HL60; HT_HG-U133A	TMEM70 LAD1 LRP6 DOCK6 MRTFA	2.01e-04	191	64	5	2955_UP
Drug	glipizide	GPAM HBG1 HBG2	2.09e-04	41	64	3	CID000003478
Drug	Procaine hydrochloride [51-05-8]; Down 200; 14.6uM; MCF7; HT_HG-U133A	ZNF93 SLC44A1 TMEM53 GLP1R MRTFA	2.11e-04	193	64	5	5430_DN
Drug	HX 600	RXRB RXRG	2.15e-04	8	64	2	ctd:C104181
Drug	cis-MCG-I	GRM2 GRM3	2.15e-04	8	64	2	CID003035584
Drug	TTNN	RXRB RXRG	2.15e-04	8	64	2	CID000135754
Drug	Tretinoin	RXRB RXRG	2.15e-04	8	64	2	DB00755
Drug	AC1O5JP6	RXRB RXRG	2.15e-04	8	64	2	CID006435379
Drug	Clomiphene citrate (Z,E) [50-41-9]; Up 200; 6.6uM; MCF7; HT_HG-U133A	TMEM53 CLIP2 ASAP3 LTB4R MRTFA	2.22e-04	195	64	5	2624_UP
Drug	GSK-3 Inhibitor IX; Up 200; 0.5uM; PC3; HT_HG-U133A	TMEM53 LAD1 ASAP3 C15orf39 NID1	2.22e-04	195	64	5	7106_UP
Drug	Methoxy-8-psoralen [298-81-7]; Up 200; 18.6uM; MCF7; HT_HG-U133A	TBC1D5 GLP1R ASAP3 GRM2 MRTFA	2.22e-04	195	64	5	5007_UP
Drug	isobutyramide	GRM2 HBG1 HBG2	2.25e-04	42	64	3	CID000068424
Drug	Pancuronium bromide [15500-66-0]; Down 200; 5.4uM; PC3; HT_HG-U133A	GLP1R ASAP3 LRP6 LTB4R MRTFA	2.27e-04	196	64	5	4570_DN
Drug	Oxalamine citrate salt [1949-20-8]; Up 200; 9.2uM; PC3; HT_HG-U133A	PLBD1 TMEM53 ASAP3 GRM2 DOCK6	2.27e-04	196	64	5	6624_UP
Drug	N-Acetyl-L-leucine [1188-21-2]; Down 200; 23uM; PC3; HT_HG-U133A	TMEM53 GLP1R ASAP3 ZNF208 MRTFA	2.32e-04	197	64	5	4622_DN
Drug	Piromidic acid [19562-30-2]; Down 200; 13.8uM; MCF7; HT_HG-U133A	ABCA12 TBC1D5 LRP6 LTB4R MRTFA	2.32e-04	197	64	5	3335_DN
Drug	Picotamide monohydrate [80530-63-8]; Down 200; 10.2uM; MCF7; HT_HG-U133A	ABCA12 GLP1R USP7 LRP6 LTB4R	2.32e-04	197	64	5	2233_DN
Drug	acetazolamide	KCNK2 HBG1 HBG2 CA8	2.36e-04	107	64	4	CID000001986
Drug	Suramin sodium salt; Up 200; 10uM; MCF7; HT_HG-U133A	FLNC CLIP2 GLP1R ASAP3 USP7	2.38e-04	198	64	5	7524_UP
Drug	Flunixin meglumine [42461-84-7]; Up 200; 8.2uM; HL60; HT_HG-U133A	GBA3 ZNF93 SLC16A4 GLP1R ASAP3	2.38e-04	198	64	5	2552_UP
Drug	Proparacaine hydrochloride [5875-06-9]; Down 200; 12uM; PC3; HT_HG-U133A	STAG1 LAD1 LRP6 EP300 MRTFA	2.38e-04	198	64	5	6332_DN
Drug	Dyclonine hydrochloride [536-43-6]; Down 200; 12.2uM; HL60; HT_HG-U133A	TMEM53 TBC1D5 GLP1R LRP6 MRTFA	2.38e-04	198	64	5	2392_DN
Drug	Dehydrocholic acid [81-23-2]; Down 200; 9.6uM; PC3; HT_HG-U133A	TMEM53 ASAP3 USP7 ZNF208 MRTFA	2.38e-04	198	64	5	4620_DN
Drug	Sulfamonomethoxine [1220-83-3]; Down 200; 14.2uM; MCF7; HT_HG-U133A	ZNF93 ASAP3 LRP6 C15orf39 DOCK6	2.38e-04	198	64	5	7200_DN
Drug	Glyset	GBA3 HBG1 HBG2	2.41e-04	43	64	3	CID000051577
Drug	Clopamide [636-54-4]; Up 200; 11.6uM; MCF7; HT_HG-U133A	TMEM53 CLIP2 ASAP3 LTB4R MRTFA	2.43e-04	199	64	5	3220_UP
Drug	Ribostamycin sulfate salt [53797-35-6]; Down 200; 7.2uM; MCF7; HT_HG-U133A	SLC44A1 TMEM53 ABCA12 GLP1R DOCK6	2.43e-04	199	64	5	6765_DN
Drug	Medrysone [2668-66-8]; Up 200; 11.6uM; MCF7; HT_HG-U133A	FLNC GLP1R ASAP3 LTB4R MRTFA	2.43e-04	199	64	5	3603_UP
Drug	butein; Up 200; 10uM; PC3; HG-U133A	GLP1R ASAP3 LRP6 LTB4R EP300	2.43e-04	199	64	5	582_UP
Drug	Rifampicin [13292-46-1]; Down 200; 4.8uM; HL60; HT_HG-U133A	ZNF93 TMEM53 GLP1R DOCK6 MRTFA	2.43e-04	199	64	5	2487_DN
Drug	Yohimbinic acid monohydrate [27801-27-2]; Down 200; 11.2uM; HL60; HT_HG-U133A	ZNF93 TMEM53 GLP1R LAD1 MRTFA	2.43e-04	199	64	5	2147_DN
Drug	Beta-Escin [11072-93-8]; Down 200; 3.2uM; MCF7; HT_HG-U133A	ABCA12 GLP1R LRP6 LTB4R MRTFA	2.49e-04	200	64	5	4364_DN
Drug	nitrosobenzene	TKT HBG1 HBG2	2.58e-04	44	64	3	CID000011473
Drug	Etretinate-d3	ABCA12 RXRB RXRG	2.76e-04	45	64	3	CID000003312
Drug	AC1N21PP	GRM2 GRM3	2.76e-04	9	64	2	CID004014619
Drug	1,3-cyclopentanedicarboxylic acid	GRM2 GRM3	2.76e-04	9	64	2	CID000107216
Drug	mM PEP	GRM2 GRM3	2.76e-04	9	64	2	CID005311462
Drug	Cefotetanum [inn-latin]	LTB4R HBG1 HBG2	2.95e-04	46	64	3	CID000050614
Disease	Hereditary persistence of fetal hemoglobin	HBG1 HBG2	1.26e-05	3	61	2	cv:C0019025
Disease	FETAL HEMOGLOBIN QUANTITATIVE TRAIT LOCUS 1	HBG1 HBG2	1.26e-05	3	61	2	141749
Disease	Addicted to cocaine	GRM2 GRM3	1.26e-05	3	61	2	C0858355
Disease	delta beta-thalassemia (is_implicated_in)	HBG1 HBG2	1.26e-05	3	61	2	DOID:0080773 (is_implicated_in)
Disease	FETAL HEMOGLOBIN QUANTITATIVE TRAIT LOCUS 1	HBG1 HBG2	2.52e-05	4	61	2	C1841621
Disease	lipoprotein measurement, phospholipid measurement	ASAP3 GPAM DOCK6 PCSK9	2.95e-05	85	61	4	EFO_0004639, EFO_0004732
Disease	choline measurement	ASAP3 GPAM DOCK6 PCSK9	1.55e-04	130	61	4	EFO_0010116
Disease	phospholipid measurement	ASAP3 GPAM DOCK6 PCSK9	2.05e-04	140	61	4	EFO_0004639
Disease	sphingomyelin measurement	CERS5 GPAM DOCK6 KCNH3 PCSK9	2.77e-04	278	61	5	EFO_0010118
Disease	Hemoglobin F Disease	HBG1 HBG2	4.34e-04	15	61	2	C0019025
Disease	lipid measurement, lipoprotein measurement	ASAP3 DOCK6 PCSK9	8.69e-04	90	61	3	EFO_0004529, EFO_0004732
Disease	Epilepsy, Benign Psychomotor, Childhood	GRM2 GRM3	1.03e-03	23	61	2	C0393672
Disease	Epilepsy, Lateral Temporal	GRM2 GRM3	1.03e-03	23	61	2	C0393682
Disease	Uncinate Epilepsy	GRM2 GRM3	1.03e-03	23	61	2	C0014558
Disease	Epilepsy, Temporal Lobe	GRM2 GRM3	1.03e-03	23	61	2	C0014556
Disease	metabolite measurement	GBA3 TKT GPAM TMEM68 ENDOG PCSK9	1.04e-03	560	61	6	EFO_0004725
Disease	lipid measurement, intermediate density lipoprotein measurement	TBC1D5 GPAM PCSK9	1.05e-03	96	61	3	EFO_0004529, EFO_0008595
Disease	total cholesterol measurement, intermediate density lipoprotein measurement	TBC1D5 GPAM PCSK9	1.14e-03	99	61	3	EFO_0004574, EFO_0008595
Disease	phospholipid measurement, intermediate density lipoprotein measurement	TBC1D5 GPAM PCSK9	1.14e-03	99	61	3	EFO_0004639, EFO_0008595
Disease	phospholipids:total lipids ratio	STAG1 GPAM DOCK6 PCSK9	1.26e-03	227	61	4	EFO_0020946
Disease	free cholesterol measurement, intermediate density lipoprotein measurement	TBC1D5 GPAM PCSK9	1.32e-03	104	61	3	EFO_0008591, EFO_0008595
Disease	functional brain measurement, language measurement	TBC1D5 SEZ6	1.53e-03	28	61	2	EFO_0007797, EFO_0007849
Disease	cholesteryl ester measurement	STAG1 GPAM DOCK6 PCSK9	1.99e-03	257	61	4	EFO_0010351

Protein segments in the cluster

Peptide	Gene	Start	Entry
YAGVLFAQKPVVHLI	ARID3B	506	Q8IVW6
HKEVFFVIRLIAGPA	EP300	1591	Q09472
LFPFIEKLAASVHAL	ASAP3	236	Q8TDY4
RAAGPAHVKLVFVDF	CDCP2	176	Q5VXM1
VAFSIGIIAIFKLPA	ABCA12	2046	Q86UK0
LPAVVFLHGLFGSKT	ABHD11	66	Q8NFV4
LGCLFAPKLHIILFQ	GRM2	806	Q14416
GFVVLGCLFAPKVHI	GRM3	811	Q14832
FGLFAPIHKVIRIGF	CLIP2	276	Q9UDT6
HILSVFPLAAGIFFV	CERS5	46	Q8N5B7
VIAALPFDLLHAFKV	KCNH3	311	Q9ULD8
FVIFHLPELKALDGI	LRRC9	1046	Q6ZRR7
LFVAPVGVASKRHLF	LAD1	431	O00515
AHSVLLGPEFKLVFS	LAMA3	3171	Q16787
LIPLLGTHEVIFAFV	GLP1R	356	P43220
HLFIGTDHLPVLFKV	CFAP65	1261	Q6ZU64
LFVALPAIIFKHIEG	KCNK2	236	O95069
ILHVFHGLLPGFLVK	PCSK9	111	Q8NBP7
KHPALLSVVIFVVFL	OR2T5	26	Q6IEZ7
AFLHVPAKVIIGLAF	NID1	971	P14543
IKHALAGLFVEILIP	FRYL	261	O94915
VPKVAGLHKVTVLFA	FLNC	341	Q14315
FCKVHPGAIVFAILA	DPY19L1	496	Q2PZI1
AFGLPIVFARAHLIE	LEPROTL1	81	O95214
VLVEDKIPHIFGFTL	LRP6	526	O75581
SLAVFVVSFLPVHLG	GPR55	231	Q9Y2T6
LIKVLPGFENILFAH	PLBD1	231	Q6P4A8
HLIFEAVTGFLLPFL	LTB4R	181	Q15722
KHPALLSVVIFVVFL	OR2T29	26	Q8NH02
KFFTLVHVLEEGAFP	DOCK6	726	Q96HP0
FHFILPFIIAALATL	MT-CYB	181	P00156
AITFHLDLFAKPIFI	GBA3	246	Q9H227
LVTVLAIHFGKEFTP	HBG1	111	P69891
AVGKPHGIAIIALFV	CA8	156	P35219
FHVAGKVFIHLPLLV	SLC44A1	321	Q8WWI5
LLKPIHVFFGAAILS	CYB561A3	151	Q8NBI2
LVTVLAIHFGKEFTP	HBG2	111	P69892
VVLHIEAVFKGPALI	DLEC1	846	Q9Y238
HPFVGLAFKLEVGRF	GFM1	351	Q96RP9
HITVVILFFGPAIFL	OR4B1	241	Q8NGF8
VFDFIGPQVHLFDKI	FER1L6	131	Q2WGJ9
EVRGAFAKLIVFIAH	USP9X	2111	Q93008
PTHFFKVLILEAAGG	ENDOG	226	Q14249
IPIFSTLIHKLGGFF	GPAM	261	Q9HCL2
FFTLLFAHIAAVPIK	MEP1A	11	Q16819
TLIGLFFAGIHKRVV	CNEP1R1	76	Q8N9A8
FFAGIHKRVVAPSII	CNEP1R1	81	Q8N9A8
HKAGEVVVAFPAARL	MRTFA	401	Q969V6
HLFFFKLIGDTPIDT	RXRB	506	P28702
VVRAGAIFVPIHLVK	C15orf39	836	Q6ZRI6
VFLGIVVSKPDLIAH	ZNF93	41	P35789
YVLKGHIAVSAAVFP	XPNPEP1	446	Q9NQW7
RGLAFVTALLFAVHP	TMTC1	141	Q8IUR5
ADHFVFKIPGFSLLL	TMEM68	156	Q96MH6
FIPTFHLVARAKTLG	SLC16A4	316	O15374
FVLSKGHAAPILYAV	TKT	71	P29401
AFALVVVLFHVLLAP	TMEM53	176	Q6P2H8
DLFHVLVGAVLAFPS	UBR1	1401	Q8IWV7
HLFFFKLIGDTPIDT	RXRG	436	P48443
LDAAHIAAAIFLPLV	SEZ6	921	Q53EL9
PVAVAAGEFLHKKLF	STAG1	426	Q8WVM7
VFLGIAAFKPDLIIF	ZNF208	41	O43345
PFIGDVHSLILKALF	TBC1D5	396	Q92609
FTVITPVLLHFITKG	TMEM70	151	Q9BUB7
HKEVFGTFGIPFLLR	USP7	996	Q93009
FPDIKGFVIVHVATA	TGM6	691	O95932