Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-25 ERVK-9 NRIP3	7.33e-13	37	40	7	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-25 ERVK-9 NRIP3	8.97e-13	38	40	7	GO:0070001
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-25 ERVK-9 RHBDF2 NRIP3	1.82e-06	430	40	8	GO:0004175
GeneOntologyMolecularFunction	N-acylphosphatidylethanolamine-specific phospholipase D activity	PLD1 PLD2	1.17e-05	3	40	2	GO:0070290
GeneOntologyMolecularFunction	peptidase activity	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-25 ERVK-9 RHBDF2 NRIP3	3.86e-05	654	40	8	GO:0008233
GeneOntologyMolecularFunction	zinc ion binding	ERVK-8 ERVK-6 ERVK-19 CHD4 ERVK-21 ERVK-9 UBR5 EP300 MAP3K1	5.28e-05	891	40	9	GO:0008270
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	SMARCAD1 CHD4 INO80	5.52e-05	37	40	3	GO:0140658
GeneOntologyMolecularFunction	phospholipase D activity	PLD1 PLD2	1.09e-04	8	40	2	GO:0004630
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERVK-8 ERVK-6 SMARCAD1 CHD4 INO80	1.69e-04	262	40	5	GO:0140097
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-8 ERVK-6	2.13e-04	11	40	2	GO:0004523
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-8 ERVK-6	3.51e-04	14	40	2	GO:0003964
GeneOntologyMolecularFunction	transition metal ion binding	ERVK-8 ERVK-6 ERVK-19 CHD4 ERVK-21 ERVK-9 UBR5 EP300 MAP3K1	4.66e-04	1189	40	9	GO:0046914
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-8 ERVK-6	8.02e-04	21	40	2	GO:0035613
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	SMARCAD1 CHD4 INO80	2.09e-03	127	40	3	GO:0008094
GeneOntologyMolecularFunction	mitogen-activated protein kinase binding	EP300 MAP3K1	2.23e-03	35	40	2	GO:0051019
GeneOntologyMolecularFunction	NF-kappaB binding	EP300 HDAC2	2.36e-03	36	40	2	GO:0051059
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-8 ERVK-6	2.49e-03	37	40	2	GO:0016891
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-8 ERVK-6	2.63e-03	38	40	2	GO:0034061
GeneOntologyMolecularFunction	transcription coregulator binding	CHD4 EP300 HDAC2	2.76e-03	140	40	3	GO:0001221
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-8 ERVK-6	3.83e-03	46	40	2	GO:0016893
GeneOntologyMolecularFunction	protein serine/threonine/tyrosine kinase activity	RPS6KA2 MAP3K1	4.00e-03	47	40	2	GO:0004712
GeneOntologyMolecularFunction	chromatin DNA binding	CHD4 EP300 HDAC2	4.52e-03	167	40	3	GO:0031490
GeneOntologyMolecularFunction	nucleosomal DNA binding	CHD4 HDAC2	7.97e-03	67	40	2	GO:0031492
GeneOntologyMolecularFunction	structural molecule activity	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-25 ERVK-9	8.14e-03	891	40	6	GO:0005198
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	ERVK-8 ERVK-6 SMARCAD1 CHD4 INO80	8.95e-03	645	40	5	GO:0140640
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	ERVK-8 ERVK-6 PIP4K2C TRRAP RPS6KA2 MAP3K1	1.03e-02	938	40	6	GO:0016772
GeneOntologyMolecularFunction	histone modifying activity	HUWE1 EP300 HDAC2	1.08e-02	229	40	3	GO:0140993
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-8 ERVK-6	1.09e-02	79	40	2	GO:0004521
GeneOntologyMolecularFunction	promoter-specific chromatin binding	EP300 HDAC2	1.20e-02	83	40	2	GO:1990841
GeneOntologyBiologicalProcess	cell-cell fusion	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9	6.20e-07	85	40	5	GO:0140253
GeneOntologyBiologicalProcess	syncytium formation by plasma membrane fusion	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9	6.20e-07	85	40	5	GO:0000768
GeneOntologyBiologicalProcess	syncytium formation	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9	7.80e-07	89	40	5	GO:0006949
GeneOntologyBiologicalProcess	DNA damage response	ERVK-8 ERVK-6 SMARCAD1 CHD4 INO80 HUWE1 PPP4R3C UBR5 TRRAP EP300	1.07e-05	959	40	10	GO:0006974
GeneOntologyBiologicalProcess	viral process	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9 EP300 MAP3K1	2.73e-05	464	40	7	GO:0016032
GeneOntologyBiologicalProcess	DNA repair	ERVK-8 ERVK-6 SMARCAD1 CHD4 INO80 HUWE1 UBR5 TRRAP	2.87e-05	648	40	8	GO:0006281
GeneOntologyBiologicalProcess	chromatin organization	SMARCAD1 CHD4 INO80 HUWE1 PRDM5 UBR5 TRRAP EP300 HDAC2	4.29e-05	896	40	9	GO:0006325
GeneOntologyBiologicalProcess	DNA recombination	ERVK-8 ERVK-6 SMARCAD1 CHD4 INO80 TRRAP	7.12e-05	368	40	6	GO:0006310
GeneOntologyBiologicalProcess	protein-DNA complex organization	SMARCAD1 CHD4 INO80 HUWE1 PRDM5 UBR5 TRRAP EP300 HDAC2	9.94e-05	999	40	9	GO:0071824
GeneOntologyBiologicalProcess	regulation of cell fate commitment	CHD4 EP300 HDAC2	1.48e-04	53	40	3	GO:0010453
GeneOntologyBiologicalProcess	regulation of organelle organization	TOGARAM1 INO80 HUWE1 PIP4K2C ARMH3 EP300 RPS6KA2 MAP3K1 HDAC2 TBC1D2	1.84e-04	1342	40	10	GO:0033043
GeneOntologyBiologicalProcess	DNA integration	ERVK-8 ERVK-6	2.82e-04	13	40	2	GO:0015074
GeneOntologyBiologicalProcess	regulation of sarcomere organization	EP300 HDAC2	2.82e-04	13	40	2	GO:0060297
GeneOntologyBiologicalProcess	eyelid development in camera-type eye	MAP3K1 HDAC2	4.33e-04	16	40	2	GO:0061029
GeneOntologyBiologicalProcess	chromatin remodeling	SMARCAD1 CHD4 INO80 HUWE1 UBR5 EP300 HDAC2	4.97e-04	741	40	7	GO:0006338
GeneOntologyCellularComponent	SWI/SNF superfamily-type complex	CHD4 INO80 TRRAP HDAC2	3.36e-05	96	40	4	GO:0070603
GeneOntologyCellularComponent	ATPase complex	CHD4 INO80 TRRAP HDAC2	1.06e-04	129	40	4	GO:1904949
GeneOntologyCellularComponent	NuRD complex	CHD4 HDAC2	4.77e-04	17	40	2	GO:0016581
GeneOntologyCellularComponent	CHD-type complex	CHD4 HDAC2	4.77e-04	17	40	2	GO:0090545
GeneOntologyCellularComponent	histone deacetylase complex	CHD4 TRRAP HDAC2	5.75e-04	85	40	3	GO:0000118
GeneOntologyCellularComponent	transcription regulator complex	BCL9L PRDM10 CHD4 TRRAP EP300 HDAC2	8.81e-04	596	40	6	GO:0005667
GeneOntologyCellularComponent	INO80-type complex	INO80 TRRAP	1.31e-03	28	40	2	GO:0097346
GeneOntologyCellularComponent	nuclear chromosome	SMARCAD1 INO80 TRRAP HDAC2	1.38e-03	254	40	4	GO:0000228
GeneOntologyCellularComponent	chromatin	BNC2 SMARCAD1 PRDM10 CHD4 INO80 UBR5 TRRAP EP300 HDAC2	1.61e-03	1480	40	9	GO:0000785
HumanPheno	Abnormal toe morphology	SMG9 RPGRIP1 TOGARAM1 SMARCAD1 HUWE1 RHBDF2 PRDM5 TRRAP SLC35C1 EP300	3.35e-05	893	15	10	HP:0001780
Domain	PLipase_D1/D2	PLD1 PLD2	2.84e-06	2	32	2	IPR016555
Domain	PLipase_D_fam	PLD1 PLD2	2.84e-06	2	32	2	IPR015679
Domain	PLDc_2	PLD1 PLD2	8.52e-06	3	32	2	PF13091
Domain	PLD-like_dom	PLD1 PLD2	8.52e-06	3	32	2	IPR025202
Domain	PLDc	PLD1 PLD2	1.70e-05	4	32	2	PF00614
Domain	SNF2_N	SMARCAD1 CHD4 INO80	2.19e-05	32	32	3	PF00176
Domain	SNF2_N	SMARCAD1 CHD4 INO80	2.19e-05	32	32	3	IPR000330
Domain	PLDc	PLD1 PLD2	4.25e-05	6	32	2	SM00155
Domain	PLD	PLD1 PLD2	5.94e-05	7	32	2	PS50035
Domain	PLipase_D/transphosphatidylase	PLD1 PLD2	5.94e-05	7	32	2	IPR001736
Domain	ARM-type_fold	TOGARAM1 HUWE1 ARMH3 TRRAP MAP3K1	2.57e-04	339	32	5	IPR016024
Domain	zf-C2H2_jaz	PRDM10 PRDM5	6.43e-04	22	32	2	PF12171
Domain	Znf_C2H2_jaz	PRDM10 PRDM5	6.43e-04	22	32	2	IPR022755
Domain	Helicase_C	SMARCAD1 CHD4 INO80	8.03e-04	107	32	3	PF00271
Domain	HELICc	SMARCAD1 CHD4 INO80	8.03e-04	107	32	3	SM00490
Domain	Helicase_C	SMARCAD1 CHD4 INO80	8.25e-04	108	32	3	IPR001650
Domain	HELICASE_CTER	SMARCAD1 CHD4 INO80	8.48e-04	109	32	3	PS51194
Domain	HELICASE_ATP_BIND_1	SMARCAD1 CHD4 INO80	8.48e-04	109	32	3	PS51192
Domain	DEXDc	SMARCAD1 CHD4 INO80	8.48e-04	109	32	3	SM00487
Domain	Helicase_ATP-bd	SMARCAD1 CHD4 INO80	8.71e-04	110	32	3	IPR014001
Domain	HECT	HUWE1 UBR5	9.72e-04	27	32	2	PF00632
Domain	HECTc	HUWE1 UBR5	9.72e-04	27	32	2	SM00119
Domain	HECT_dom	HUWE1 UBR5	9.72e-04	27	32	2	IPR000569
Domain	HECT	HUWE1 UBR5	9.72e-04	27	32	2	PS50237
Domain	PX	PLD1 PLD2	2.57e-03	44	32	2	SM00312
Domain	PX	PLD1 PLD2	3.18e-03	49	32	2	PF00787
Domain	SET_dom	PRDM10 PRDM5	3.31e-03	50	32	2	IPR001214
Domain	SET	PRDM10 PRDM5	3.31e-03	50	32	2	PS50280
Domain	PX	PLD1 PLD2	3.31e-03	50	32	2	PS50195
Domain	-	PLD1 PLD2	3.44e-03	51	32	2	3.30.1520.10
Domain	Phox	PLD1 PLD2	3.57e-03	52	32	2	IPR001683
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION	CHD4 PIP4K2C EP300 HDAC2	1.72e-07	30	24	4	M27637
Pathway	REACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX	BCL9L TRRAP EP300	1.10e-05	26	24	3	MM14793
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION	CHD4 PIP4K2C EP300	1.54e-05	29	24	3	MM15340
Pathway	BIOCARTA_CB1R_PATHWAY	PLD1 PLD2	5.80e-05	7	24	2	MM1569
Pathway	BIOCARTA_CB1R_PATHWAY	PLD1 PLD2	5.80e-05	7	24	2	M22054
Pathway	REACTOME_SYNTHESIS_OF_PG	PLD1 PLD2	7.73e-05	8	24	2	M26961
Pathway	REACTOME_PI5P_REGULATES_TP53_ACETYLATION	PIP4K2C EP300	9.93e-05	9	24	2	M27655
Pathway	REACTOME_PI5P_REGULATES_TP53_ACETYLATION	PIP4K2C EP300	9.93e-05	9	24	2	MM15357
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY	CHD4 PIP4K2C EP300 HDAC2	1.42e-04	160	24	4	M27498
Pathway	REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION	CHD4 EP300 RPS6KA2	1.46e-04	61	24	3	M152
Pathway	WP_EGFEGFR_SIGNALING	PLD1 PLD2 RPS6KA2 MAP3K1	1.49e-04	162	24	4	M39334
Pathway	REACTOME_STAT3_NUCLEAR_EVENTS_DOWNSTREAM_OF_ALK_SIGNALING	EP300 HDAC2	1.51e-04	11	24	2	M42523
Pathway	PID_HDAC_CLASSI_PATHWAY	CHD4 EP300 HDAC2	1.85e-04	66	24	3	M101
Pathway	WP_EGFR1_SIGNALING_PATHWAY	PLD1 PLD2 RPS6KA2 MAP3K1	2.64e-04	188	24	4	MM15828
Pathway	PID_ARF6_DOWNSTREAM_PATHWAY	PLD1 PLD2	2.88e-04	15	24	2	M120
Pathway	BIOCARTA_PITX2_PATHWAY	TRRAP EP300	2.88e-04	15	24	2	MM1439
Pathway	PID_MYC_ACTIV_PATHWAY	HUWE1 TRRAP EP300	3.15e-04	79	24	3	M66
Pathway	PID_BETA_CATENIN_NUC_PATHWAY	TRRAP EP300 HDAC2	3.27e-04	80	24	3	M223
Pathway	BIOCARTA_MEF2D_PATHWAY	EP300 HDAC2	3.29e-04	16	24	2	MM1483
Pathway	BIOCARTA_PITX2_PATHWAY	TRRAP EP300	3.29e-04	16	24	2	M8516
Pathway	BIOCARTA_MEF2D_PATHWAY	EP300 HDAC2	4.18e-04	18	24	2	M5290
Pathway	REACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX	BCL9L TRRAP EP300	4.77e-04	91	24	3	M27101
Pathway	WP_CALCIUM_MEDIATED_TCELL_APOPTOSIS_INVOLVED_IN_INCLUSION_BODY_MYOSITIS	EP300 HDAC2	5.18e-04	20	24	2	M48330
Pathway	BIOCARTA_RAC1_PATHWAY	PLD1 MAP3K1	5.72e-04	21	24	2	MM1463
Pathway	BIOCARTA_RAC1_PATHWAY	PLD1 MAP3K1	5.72e-04	21	24	2	M8601
Pathway	KEGG_GNRH_SIGNALING_PATHWAY	PLD1 PLD2 MAP3K1	6.48e-04	101	24	3	M1979
Pathway	REACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION	CHD4 EP300 HDAC2	7.25e-04	105	24	3	M27425
Pathway	PID_ERBB1_DOWNSTREAM_PATHWAY	PLD1 PLD2 MAP3K1	7.25e-04	105	24	3	M164
Pathway	REACTOME_ADIPOGENESIS	CHD4 EP300 HDAC2	8.30e-04	110	24	3	M48259
Pathway	BIOCARTA_CARM_ER_PATHWAY	EP300 HDAC2	8.81e-04	26	24	2	M2499
Pathway	REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION	CHD4 RPS6KA2	9.50e-04	27	24	2	MM14779
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	CHD4 TRRAP EP300 HDAC2	1.06e-03	272	24	4	M29619
Pathway	REACTOME_SIGNALING_BY_ALK	EP300 HDAC2	1.17e-03	30	24	2	M42517
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_OF_BROWN_AND_BEIGE_ADIPOCYTE_DIFFERENTIATION	CHD4 HDAC2	1.25e-03	31	24	2	M48258
Pathway	WP_INITIATION_OF_TRANSCRIPTION_AND_TRANSLATION_ELONGATION_AT_THE_HIV1_LTR	EP300 HDAC2	1.34e-03	32	24	2	M39521
Pathway	PID_ALPHA_SYNUCLEIN_PATHWAY	PLD1 PLD2	1.34e-03	32	24	2	M275
Pathway	KEGG_ETHER_LIPID_METABOLISM	PLD1 PLD2	1.42e-03	33	24	2	M2130
Pathway	REACTOME_SIGNALING_BY_NTRKS	CHD4 EP300 RPS6KA2	1.47e-03	134	24	3	M3574
Pathway	KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS	HUWE1 UBR5 MAP3K1	1.50e-03	135	24	3	M15247
Pathway	WP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY	SMARCAD1 CHD4 EP300 HDAC2	1.54e-03	301	24	4	MM15983
Pathway	PID_P53_DOWNSTREAM_PATHWAY	TRRAP EP300 HDAC2	1.57e-03	137	24	3	M145
Pathway	WP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_MAPK_SIGNALING	RPS6KA2 MAP3K1	1.69e-03	36	24	2	M39908
Pathway	WP_EFFECT_OF_PROGERIN_ON_GENES_INVOLVED_IN_PROGERIA	CHD4 HDAC2	1.78e-03	37	24	2	M39756
Pathway	REACTOME_NGF_STIMULATED_TRANSCRIPTION	CHD4 EP300	1.98e-03	39	24	2	M29793
Pathway	REACTOME_SYNTHESIS_OF_PA	PLD1 PLD2	1.98e-03	39	24	2	M653
Pathway	PID_IFNG_PATHWAY	EP300 MAP3K1	2.08e-03	40	24	2	M161
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY	CHD4 PIP4K2C EP300	2.31e-03	157	24	3	MM15226
Pathway	REACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT	BCL9L TRRAP EP300	2.35e-03	158	24	3	MM14791
Pathway	PID_RHOA_PATHWAY	PLD1 PLD2	2.63e-03	45	24	2	M12
Pathway	KEGG_NOTCH_SIGNALING_PATHWAY	EP300 HDAC2	2.87e-03	47	24	2	M7946
Pathway	REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION_INITIATION	CHD4 HDAC2	2.87e-03	47	24	2	M1095
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_TP53	CHD4 PIP4K2C EP300 HDAC2	2.97e-03	360	24	4	M27267
Pathway	WP_RETT_SYNDROME	CHD4 TRRAP	2.99e-03	48	24	2	M39759
Pathway	REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	EP300 HDAC2	2.99e-03	48	24	2	M611
Pathway	PID_ARF6_TRAFFICKING_PATHWAY	PLD1 PLD2	3.11e-03	49	24	2	M67
Pathway	PID_NFAT_3PATHWAY	EP300 MAP3K1	3.63e-03	53	24	2	M113
Pathway	KEGG_INOSITOL_PHOSPHATE_METABOLISM	ISYNA1 PIP4K2C	3.77e-03	54	24	2	M3896
Pathway	REACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER	EP300 HDAC2	4.33e-03	58	24	2	M29616
Pathway	PID_P53_REGULATION_PATHWAY	HUWE1 EP300	4.48e-03	59	24	2	M261
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9	1.22e-12	12	40	5	14557543
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-25 ERVK-9 ERVK-16	1.45e-11	94	40	7	21542922
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-19 ERVK-9 ERVK-16	2.25e-11	6	40	4	15063128
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-19 ERVK-21	1.41e-08	5	40	3	12629516
Pubmed	P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma.	HUWE1 UBR5 TRRAP EP300	1.86e-08	25	40	4	36708875
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SMARCAD1 CHD4 PLD1 INO80 PIP4K2C ACAD11 PRDM5 UBR5 TRRAP EP300 HDAC2	3.48e-08	1116	40	11	31753913
Pubmed	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.	BCL9L UBR5 EP300 HDAC2	6.78e-08	34	40	4	30894540
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-6 ERVK-19 ERVK-21	1.68e-07	10	40	3	12970426
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	SMARCAD1 CHD4 HUWE1 UBR5 HDAC2	8.97e-07	153	40	5	26365490
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	CHD4 INO80 TRRAP EP300 HDAC2	1.02e-06	157	40	5	30186101
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-21 ERVK-25 ERVK-9	1.14e-06	18	40	3	18664271
Pubmed	β-1,3-Glucan-induced host phospholipase D activation is involved in Aspergillus fumigatus internalization into type II human pneumocyte A549 cells.	PLD1 PLD2	1.29e-06	2	40	2	21760893
Pubmed	Pharmacological inhibition of phospholipase D protects mice from occlusive thrombus formation and ischemic stroke--brief report.	PLD1 PLD2	1.29e-06	2	40	2	23868933
Pubmed	Genomic analysis of murine phospholipase D1 and comparison to phospholipase D2 reveals an unusual difference in gene size.	PLD1 PLD2	1.29e-06	2	40	2	9813240
Pubmed	Transcriptional repression of cyclin-dependent kinase inhibitor p21 gene by phospholipase D1 and D2.	PLD1 PLD2	1.29e-06	2	40	2	12782287
Pubmed	Mono- and Poly-unsaturated Phosphatidic Acid Regulate Distinct Steps of Regulated Exocytosis in Neuroendocrine Cells.	PLD1 PLD2	1.29e-06	2	40	2	32814056
Pubmed	Phospholipase D isoforms differentially regulate leukocyte responses to acute lung injury.	PLD1 PLD2	1.29e-06	2	40	2	29437245
Pubmed	Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2.	PLD1 PLD2	1.29e-06	2	40	2	9582313
Pubmed	Functional analysis of mammalian phospholipase D enzymes.	PLD1 PLD2	1.29e-06	2	40	2	30369483
Pubmed	Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2.	PLD1 PLD2	1.29e-06	2	40	2	16873675
Pubmed	PLD1 promotes reactive oxygen species production in vascular smooth muscle cells and injury-induced neointima formation.	PLD1 PLD2	1.29e-06	2	40	2	34610470
Pubmed	Differential regulation of apoptosis by caspase-mediated cleavage of phospholipase D isozymes.	PLD1 PLD2	1.29e-06	2	40	2	18694819
Pubmed	Structure and regulation of human phospholipase D.	PLD1 PLD2	1.29e-06	2	40	2	33495125
Pubmed	Generation of choline for acetylcholine synthesis by phospholipase D isoforms.	PLD1 PLD2	1.29e-06	2	40	2	11734063
Pubmed	PLD1 and PLD2 differentially regulate the balance of macrophage polarization in inflammation and tissue injury.	PLD1 PLD2	1.29e-06	2	40	2	33368247
Pubmed	Phospholipases D1 and D2 Suppress Appetite and Protect against Overweight.	PLD1 PLD2	1.29e-06	2	40	2	27299737
Pubmed	The phospholipase D pathway mediates the inflammatory response of the retinal pigment epithelium.	PLD1 PLD2	1.29e-06	2	40	2	25172550
Pubmed	Deficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment.	PLD1 PLD2	1.29e-06	2	40	2	23383154
Pubmed	Characterization of human PLD2 and the analysis of PLD isoform splice variants.	PLD1 PLD2	1.29e-06	2	40	2	9761774
Pubmed	The molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase D.	PLD1 PLD2	1.29e-06	2	40	2	25187519
Pubmed	Phospholipase D in TCR-Mediated Signaling and T Cell Activation.	PLD1 PLD2	1.29e-06	2	40	2	29386256
Pubmed	Phospholipase D1 is a regulator of platelet-mediated inflammation.	PLD1 PLD2	1.29e-06	2	40	2	28711718
Pubmed	Expression of MARCKS effector domain mutants alters phospholipase D activity and cytoskeletal morphology of SK-N-MC neuroblastoma cells.	PLD1 PLD2	1.29e-06	2	40	2	16341931
Pubmed	Increased phospholipase D activity contributes to tumorigenesis in prostate cancer cell models.	PLD1 PLD2	1.29e-06	2	40	2	32661773
Pubmed	Phospholipase D is involved in the formation of Golgi associated clathrin coated vesicles in human parotid duct cells.	PLD1 PLD2	1.29e-06	2	40	2	24618697
Pubmed	Phospholipase D in cell proliferation and cancer.	PLD1 PLD2	1.29e-06	2	40	2	14517341
Pubmed	Phospholipase D is essential for keratocyte-like migration of NBT-II cells.	PLD1 PLD2	1.29e-06	2	40	2	18344600
Pubmed	Positive feedback regulation between phospholipase D and Wnt signaling promotes Wnt-driven anchorage-independent growth of colorectal cancer cells.	PLD1 PLD2	1.29e-06	2	40	2	20711340
Pubmed	Importance of PLD2 in an IL-23 driven psoriasiform dermatitis model and potential link to human psoriasis.	PLD1 PLD2	1.29e-06	2	40	2	37455419
Pubmed	Phospholipase D1 and D2 Synergistically Regulate Thrombus Formation.	PLD1 PLD2	1.29e-06	2	40	2	32971863
Pubmed	Role of phospholipases D1 and 2 in astroglial proliferation: effects of specific inhibitors and genetic deletion.	PLD1 PLD2	1.29e-06	2	40	2	25967349
Pubmed	Involvement of Phospholipase D 1 and 2 in the subcellular localization and activity of formyl-peptide-receptors in the human colonic cell line HT29.	PLD1 PLD2	1.29e-06	2	40	2	19707939
Pubmed	Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis.	PLD1 PLD2	1.29e-06	2	40	2	23131846
Pubmed	Phospholipase D: A new mediator during high phosphate-induced vascular calcification associated with chronic kidney disease.	PLD1 PLD2	1.29e-06	2	40	2	30207376
Pubmed	Redundant functions of phospholipases D1 and D2 in platelet α-granule release.	PLD1 PLD2	1.29e-06	2	40	2	22974101
Pubmed	Increased expression of two phospholipase D isoforms during experimentally induced hippocampal mossy fiber outgrowth.	PLD1 PLD2	1.29e-06	2	40	2	14999815
Pubmed	Phospholipase D is a target for inhibition of astroglial proliferation by ethanol.	PLD1 PLD2	1.29e-06	2	40	2	24262632
Pubmed	Enzymatic Activity Is Not Required for Phospholipase D Mediated TNF-α Regulation and Myocardial Healing.	PLD1 PLD2	1.29e-06	2	40	2	30555342
Pubmed	Role of phospholipase D in bleomycin-induced mitochondrial reactive oxygen species generation, mitochondrial DNA damage, and pulmonary fibrosis.	PLD1 PLD2	1.29e-06	2	40	2	31090437
Pubmed	The influence of polyunsaturated fatty acids on the phospholipase D isoforms trafficking and activity in mast cells.	PLD1 PLD2	1.29e-06	2	40	2	23698760
Pubmed	Phosphatidic acid, phospholipase D and tumorigenesis.	PLD1 PLD2	1.29e-06	2	40	2	24103483
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	1.29e-06	2	40	2	9060628
Pubmed	Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells.	PLD1 PLD2	1.29e-06	2	40	2	12615079
Pubmed	Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid.	PLD1 PLD2	1.29e-06	2	40	2	25523098
Pubmed	Exosome Secretion and Epithelial-Mesenchymal Transition in Ovarian Cancer Are Regulated by Phospholipase D.	PLD1 PLD2	1.29e-06	2	40	2	36362078
Pubmed	Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.	ERVK-6 ERVK-19	1.29e-06	2	40	2	9460924
Pubmed	Phospholipase D messenger RNA expression and clinical role in high-grade serous carcinoma.	PLD1 PLD2	1.29e-06	2	40	2	28087476
Pubmed	Impaired brain development and reduced cognitive function in phospholipase D-deficient mice.	PLD1 PLD2	1.29e-06	2	40	2	24813107
Pubmed	Expression of phospholipase D isozymes in mouse lungs during postnatal development.	PLD1 PLD2	1.29e-06	2	40	2	19652486
Pubmed	Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization.	PLD1 PLD2	1.29e-06	2	40	2	9395408
Pubmed	Platelet derived growth factor increases phospholipase D1 but not phospholipase D2 expression via NFkappaB signaling pathway and enhances invasion of breast cancer cells.	PLD1 PLD2	1.29e-06	2	40	2	20188462
Pubmed	Differential expression of phospholipases D1 and D2 in mouse tissues.	PLD1 PLD2	1.29e-06	2	40	2	17085061
Pubmed	Organization and alternative splicing of the murine phospholipase D2 gene.	PLD1 PLD2	1.29e-06	2	40	2	9560313
Pubmed	Phospholipase D in human platelets: presence of isoenzymes and participation of autocrine stimulation during thrombin activation.	PLD1 PLD2	1.29e-06	2	40	2	18432522
Pubmed	Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning.	PLD1 PLD2	1.29e-06	2	40	2	32209478
Pubmed	Phospholipase D and cancer metastasis: A focus on exosomes.	PLD1 PLD2	1.29e-06	2	40	2	36272918
Pubmed	Cross-talk between phospholipase D and MAP kinases activities.	PLD1 PLD2	1.29e-06	2	40	2	19896495
Pubmed	Up-regulation of cyclooxygenase-2 by cobalt chloride-induced hypoxia is mediated by phospholipase D isozymes in human astroglioma cells.	PLD1 PLD2	3.87e-06	3	40	2	17640750
Pubmed	Acetylation-Dependent Control of Global Poly(A) RNA Degradation by CBP/p300 and HDAC1/2.	EP300 HDAC2	3.87e-06	3	40	2	27635759
Pubmed	Involvement of phospholipase D in regulating expression of anti-microbial peptide human beta-defensin-2.	PLD1 PLD2	3.87e-06	3	40	2	17986621
Pubmed	Molecular mechanisms of N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation and degranulation in mouse neutrophils: phospholipase D is dispensable.	PLD1 PLD2	3.87e-06	3	40	2	23109426
Pubmed	Differential Roles of Phospholipase D Proteins in FcεRI-Mediated Signaling and Mast Cell Function.	PLD1 PLD2	3.87e-06	3	40	2	26392467
Pubmed	ATRA activates and PDGF-BB represses the SM22α promoter through KLF4 binding to, or dissociating from, its cis-DNA elements.	EP300 HDAC2	3.87e-06	3	40	2	21252119
Pubmed	Involvement of phospholipases D1 and D2 in sphingosine 1-phosphate-induced ERK (extracellular-signal-regulated kinase) activation and interleukin-8 secretion in human bronchial epithelial cells.	PLD1 PLD2	3.87e-06	3	40	2	12149127
Pubmed	Phospholipase D confers rapamycin resistance in human breast cancer cells.	PLD1 PLD2	3.87e-06	3	40	2	12813467
Pubmed	Phospholipase D isozymes mediate epigallocatechin gallate-induced cyclooxygenase-2 expression in astrocyte cells.	PLD1 PLD2	3.87e-06	3	40	2	15210717
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-19	3.87e-06	3	40	2	10516026
Pubmed	Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity.	PLD1 PLD2	3.87e-06	3	40	2	11032811
Pubmed	Acetylation inactivates the transcriptional repressor BCL6.	EP300 HDAC2	3.87e-06	3	40	2	12402037
Pubmed	Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling β-catenin signaling in cancer-initiating cells.	PLD1 PLD2	3.87e-06	3	40	2	26122663
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-9	3.87e-06	3	40	2	9971820
Pubmed	Regulation of Phospholipase D by Arf6 during FcγR-Mediated Phagocytosis.	PLD1 PLD2	3.87e-06	3	40	2	30944160
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	SMARCAD1 PRDM10 CHD4 HUWE1 UBR5 TRRAP EP300 HDAC2	5.03e-06	857	40	8	25609649
Pubmed	The adenovirus E1A oncoprotein recruits the cellular TRRAP/GCN5 histone acetyltransferase complex.	TRRAP EP300	7.73e-06	4	40	2	12743606
Pubmed	Munc-18-1 inhibits phospholipase D activity by direct interaction in an epidermal growth factor-reversible manner.	PLD1 PLD2	7.73e-06	4	40	2	14744865
Pubmed	Oxidized LDL phagocytosis during foam cell formation in atherosclerotic plaques relies on a PLD2-CD36 functional interdependence.	PLD1 PLD2	7.73e-06	4	40	2	29656494
Pubmed	The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis.	PLD1 PLD2	7.73e-06	4	40	2	16622417
Pubmed	Actin directly interacts with phospholipase D, inhibiting its activity.	PLD1 PLD2	7.73e-06	4	40	2	11373276
Pubmed	Regulation of phospholipase D activity and phosphatidic acid production after purinergic (P2Y6) receptor stimulation.	PLD1 PLD2	7.73e-06	4	40	2	23723068
Pubmed	Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation.	PLD1 PLD2	7.73e-06	4	40	2	23362269
Pubmed	Yin Yang 1 enhances cyclooxygenase-2 gene expression in macrophages.	EP300 HDAC2	7.73e-06	4	40	2	17220375
Pubmed	Inhibition of phospholipase D by amphiphysins.	PLD1 PLD2	7.73e-06	4	40	2	10764771
Pubmed	Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway.	PLD1 PLD2	7.73e-06	4	40	2	22024166
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-19	7.73e-06	4	40	2	7983737
Pubmed	The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development.	CHD4 EP300	7.73e-06	4	40	2	15189737
Pubmed	Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them.	PLD1 PLD2	7.73e-06	4	40	2	10926929
Pubmed	HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression.	HUWE1 HDAC2	7.73e-06	4	40	2	30818224
Pubmed	Direct stimulation of receptor-controlled phospholipase D1 by phospho-cofilin.	PLD1 PLD2	7.73e-06	4	40	2	17853892
Pubmed	Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2.	HUWE1 HDAC2	7.73e-06	4	40	2	22016339
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	CHD4 PIP4K2C ACAD11 TRRAP EP300 RPS6KA2 MAP3K1 HDAC2	7.80e-06	910	40	8	36736316
Interaction	ACTL6A interactions	SMARCAD1 CHD4 INO80 HUWE1 UBR5 TRRAP EP300 HDAC2	2.73e-08	289	35	8	int:ACTL6A
Interaction	MAF interactions	HUWE1 UBR5 EP300 HDAC2	3.47e-06	60	35	4	int:MAF
Interaction	RUVBL1 interactions	SMG9 SMARCAD1 CHD4 INO80 HUWE1 UBR5 TRRAP HDAC2	4.99e-06	575	35	8	int:RUVBL1
Interaction	SMC1A interactions	SMARCAD1 CHD4 HUWE1 UBR5 TRRAP EP300 HDAC2	6.39e-06	418	35	7	int:SMC1A
Interaction	PRSS1 interactions	CHD4 HUWE1 PRDM5 TRRAP	7.62e-06	73	35	4	int:PRSS1
Interaction	RUVBL2 interactions	SMARCAD1 CHD4 INO80 HUWE1 UBR5 TRRAP EP300 HDAC2	8.26e-06	616	35	8	int:RUVBL2
Interaction	EHMT2 interactions	SMARCAD1 CHD4 PRDM5 TRRAP EP300 HDAC2	1.54e-05	315	35	6	int:EHMT2
Interaction	TAL1 interactions	CHD4 TRRAP EP300 HDAC2	1.99e-05	93	35	4	int:TAL1
Interaction	NAP1L4 interactions	RPGRIP1 HUWE1 EP300 RPS6KA2 HDAC2	2.69e-05	206	35	5	int:NAP1L4
Interaction	IKZF4 interactions	CHD4 ZNF225 HDAC2	3.29e-05	36	35	3	int:IKZF4
Interaction	MIER2 interactions	PLD1 ACAD11 HDAC2	3.58e-05	37	35	3	int:MIER2
Interaction	VHL interactions	PLD1 PLD2 HUWE1 UBR5 EP300 MAP3K1 HDAC2	4.26e-05	561	35	7	int:VHL
Interaction	KIF13A interactions	SMARCAD1 HUWE1 TRRAP	4.54e-05	40	35	3	int:KIF13A
Interaction	BRCA2 interactions	BNC2 CHD4 HUWE1 TRRAP EP300 HDAC2	4.68e-05	384	35	6	int:BRCA2
Interaction	BUB3 interactions	HUWE1 UBR5 TRRAP EP300 HDAC2	4.74e-05	232	35	5	int:BUB3
Interaction	CACNG5 interactions	PLD1 PLD2 TRRAP	4.89e-05	41	35	3	int:CACNG5
Interaction	CDC20 interactions	HUWE1 UBR5 TRRAP EP300 HDAC2	4.94e-05	234	35	5	int:CDC20
Interaction	POU5F1 interactions	CHD4 INO80 PLD2 HUWE1 UBR5 TRRAP HDAC2	5.49e-05	584	35	7	int:POU5F1
Interaction	MED15 interactions	CHD4 INO80 ACAD11 TRRAP	7.64e-05	131	35	4	int:MED15
Interaction	ZBTB7A interactions	CHD4 HUWE1 UBR5 HDAC2	7.64e-05	131	35	4	int:ZBTB7A
Interaction	NR1I2 interactions	UBR5 TRRAP EP300	7.87e-05	48	35	3	int:NR1I2
Interaction	SIRT6 interactions	SMG9 CHD4 HUWE1 UBR5 TRRAP EP300 HDAC2	8.68e-05	628	35	7	int:SIRT6
Interaction	HIF1A interactions	CHD4 PLD1 PLD2 TRRAP EP300 HDAC2	1.01e-04	441	35	6	int:HIF1A
Interaction	SUDS3 interactions	CHD4 EP300 RPS6KA2 HDAC2	1.02e-04	141	35	4	int:SUDS3
Interaction	TNFRSF19 interactions	PLD1 PLD2 PIP4K2C	1.06e-04	53	35	3	int:TNFRSF19
Interaction	HSP90AA2P interactions	PLD2 EP300 MAP3K1	1.18e-04	55	35	3	int:HSP90AA2P
Interaction	TCF7L2 interactions	CHD4 UBR5 TRRAP EP300 HDAC2	1.25e-04	285	35	5	int:TCF7L2
Interaction	SMARCE1 interactions	SMARCAD1 CHD4 TRRAP EP300 HDAC2	1.29e-04	287	35	5	int:SMARCE1
Interaction	MRE11 interactions	CHD4 HUWE1 TRRAP EP300 HDAC2	1.29e-04	287	35	5	int:MRE11
Interaction	SSBP4 interactions	BCL9L CHD4 EP300	1.46e-04	59	35	3	int:SSBP4
Interaction	MRTFA interactions	RPGRIP1 TRRAP EP300	1.53e-04	60	35	3	int:MRTFA
Interaction	NANOG interactions	BNC2 CHD4 HUWE1 TRRAP EP300 HDAC2	1.62e-04	481	35	6	int:NANOG
Interaction	PRKDC interactions	SMARCAD1 CHD4 HUWE1 UBR5 EP300 RPS6KA2 HDAC2	1.63e-04	695	35	7	int:PRKDC
Interaction	IPO7 interactions	RPGRIP1 HUWE1 RHBDF2 EP300 RPS6KA2	1.69e-04	304	35	5	int:IPO7
Interaction	ANAPC7 interactions	SMARCAD1 HUWE1 TRRAP EP300	1.73e-04	162	35	4	int:ANAPC7
Interaction	DDX41 interactions	CHD4 UBR5 EP300 RPS6KA2	1.90e-04	166	35	4	int:DDX41
Interaction	CSNK2A2 interactions	CHD4 HUWE1 PIP4K2C TRRAP EP300 RPS6KA2 HDAC2	1.99e-04	718	35	7	int:CSNK2A2
Interaction	NFATC1 interactions	CHD4 TRRAP EP300 HDAC2	1.99e-04	168	35	4	int:NFATC1
Interaction	DHX15 interactions	CHD4 HUWE1 UBR5 TRRAP EP300 HDAC2	2.04e-04	502	35	6	int:DHX15
Interaction	TWIST1 interactions	CHD4 UBR5 EP300 HDAC2	2.09e-04	170	35	4	int:TWIST1
Interaction	H2AC20 interactions	PRDM10 CHD4 INO80 EP300 HDAC2	2.15e-04	320	35	5	int:H2AC20
Interaction	CHAF1A interactions	SMARCAD1 CHD4 HUWE1 UBR5 HDAC2	2.21e-04	322	35	5	int:CHAF1A
Interaction	EPAS1 interactions	CHD4 TRRAP EP300 HDAC2	2.23e-04	173	35	4	int:EPAS1
Interaction	ZUP1 interactions	CHD4 INO80 HUWE1 UBR5	2.28e-04	174	35	4	int:ZUP1
Interaction	ZNF8 interactions	SMARCAD1 ACAD11 PRDM5	2.43e-04	70	35	3	int:ZNF8
Interaction	KPNA2 interactions	CHD4 HUWE1 UBR5 TRRAP EP300 HDAC2	2.44e-04	519	35	6	int:KPNA2
Interaction	GPR156 interactions	PLD1 PLD2 ACAD11	2.53e-04	71	35	3	int:GPR156
Interaction	SLK interactions	CHD4 PIP4K2C RHBDF2 EP300	2.76e-04	183	35	4	int:SLK
Interaction	PRICKLE3 interactions	PRDM10 HUWE1 PIP4K2C	2.86e-04	74	35	3	int:PRICKLE3
Interaction	BCL11B interactions	CHD4 EP300 HDAC2	2.86e-04	74	35	3	int:BCL11B
Interaction	RPTOR interactions	PLD2 HUWE1 UBR5 EP300 HDAC2	2.88e-04	341	35	5	int:RPTOR
Interaction	RPL4 interactions	SMARCAD1 CHD4 INO80 HUWE1 PRDM5 MAP3K1 HDAC2	2.91e-04	764	35	7	int:RPL4
Interaction	EHMT1 interactions	SMARCAD1 CHD4 TRRAP HDAC2	3.06e-04	188	35	4	int:EHMT1
Interaction	ZBTB17 interactions	HUWE1 PRDM5 EP300	3.21e-04	77	35	3	int:ZBTB17
Interaction	KPNA1 interactions	CHD4 HUWE1 UBR5 TRRAP HDAC2	3.29e-04	351	35	5	int:KPNA1
Interaction	NONO interactions	SMARCAD1 CHD4 HUWE1 UBR5 EP300 HDAC2	3.29e-04	549	35	6	int:NONO
Interaction	HELLS interactions	SMARCAD1 CHD4 EP300 HDAC2	3.32e-04	192	35	4	int:HELLS
Interaction	PPAN interactions	PRDM10 CHD4 UBR5 EP300	3.38e-04	193	35	4	int:PPAN
Interaction	DVL2 interactions	BCL9L PLD1 PIP4K2C ACAD11 EP300 MAP3K1	3.56e-04	557	35	6	int:DVL2
Interaction	AGPS interactions	HUWE1 ACAD11 EP300 HDAC2	3.59e-04	196	35	4	int:AGPS
Interaction	ATOH1 interactions	HUWE1 UBR5 TRRAP	3.60e-04	80	35	3	int:ATOH1
Interaction	SMARCAD1 interactions	SMARCAD1 CHD4 HUWE1 HDAC2	3.66e-04	197	35	4	int:SMARCAD1
Interaction	FOXJ2 interactions	CHD4 UBR5 HDAC2	3.73e-04	81	35	3	int:FOXJ2
Interaction	SMARCB1 interactions	SMARCAD1 CHD4 UBR5 EP300 HDAC2	3.89e-04	364	35	5	int:SMARCB1
Interaction	ASIC2 interactions	PLD1 PLD2	3.92e-04	17	35	2	int:ASIC2
Interaction	NASP interactions	CHD4 HUWE1 TRRAP EP300	4.41e-04	207	35	4	int:NASP
Interaction	GPBP1L1 interactions	PIP4K2C ACAD11 HDAC2	4.45e-04	86	35	3	int:GPBP1L1
Interaction	CDKN1A interactions	UBR5 TRRAP EP300 RPS6KA2 HDAC2	4.45e-04	375	35	5	int:CDKN1A
Interaction	UPF1 interactions	SMG9 PRDM5 UBR5 TRRAP EP300 RPS6KA2	4.45e-04	581	35	6	int:UPF1
Interaction	NR4A1 interactions	CHD4 ACAD11 EP300 MAP3K1	4.83e-04	212	35	4	int:NR4A1
Interaction	ILF2 interactions	CHD4 HUWE1 ACAD11 TRRAP EP300 TBC1D2	4.83e-04	590	35	6	int:ILF2
Interaction	SMARCC1 interactions	SMARCAD1 CHD4 TRRAP EP300 HDAC2	4.96e-04	384	35	5	int:SMARCC1
Interaction	MEX3A interactions	BCL9L CHD4 HUWE1 EP300 TBC1D2	4.96e-04	384	35	5	int:MEX3A
Interaction	CDC73 interactions	BCL9L CHD4 UBR5 EP300 HDAC2	5.08e-04	386	35	5	int:CDC73
Interaction	DYRK1B interactions	TRRAP EP300 MAP3K1	5.25e-04	91	35	3	int:DYRK1B
Interaction	CFAP20 interactions	PLD1 UBR5 TRRAP	5.25e-04	91	35	3	int:CFAP20
Interaction	DCAF1 interactions	SMG9 PLD1 UBR5 HDAC2	5.94e-04	224	35	4	int:DCAF1
Interaction	FOXG1 interactions	CHD4 UBR5 HDAC2	5.95e-04	95	35	3	int:FOXG1
Interaction	RPAP3 interactions	PLD2 PIP4K2C UBR5 EP300	6.04e-04	225	35	4	int:RPAP3
Interaction	FOXK2 interactions	PRDM10 CHD4 EP300 HDAC2	6.04e-04	225	35	4	int:FOXK2
Interaction	KPNA4 interactions	CHD4 HUWE1 TRRAP HDAC2	6.04e-04	225	35	4	int:KPNA4
Interaction	DDX46 interactions	CHD4 HUWE1 UBR5 EP300	6.24e-04	227	35	4	int:DDX46
Interaction	RPS6KA1 interactions	UBR5 TRRAP RPS6KA2 HDAC2	6.34e-04	228	35	4	int:RPS6KA1
Interaction	SMC3 interactions	SMARCAD1 CHD4 TRRAP EP300 HDAC2	6.53e-04	408	35	5	int:SMC3
Interaction	TFCP2L1 interactions	CHD4 TRRAP HDAC2	6.71e-04	99	35	3	int:TFCP2L1
Interaction	SMARCA5 interactions	SMARCAD1 CHD4 INO80 HUWE1 HDAC2	7.05e-04	415	35	5	int:SMARCA5
Interaction	TMX1 interactions	HUWE1 RHBDF2 TRRAP SLC35C1	7.10e-04	235	35	4	int:TMX1
Interaction	TSPAN3 interactions	PLD2 RHBDF2 TRRAP	7.12e-04	101	35	3	int:TSPAN3
Interaction	ZCCHC10 interactions	PRDM10 PLD1 PLD2 PIP4K2C	7.22e-04	236	35	4	int:ZCCHC10
Interaction	OGG1 interactions	CHD4 HDAC2	7.25e-04	23	35	2	int:OGG1
Interaction	STXBP2 interactions	PLD2 EP300 RPS6KA2	7.53e-04	103	35	3	int:STXBP2
Interaction	ING1 interactions	TRRAP EP300 HDAC2	7.53e-04	103	35	3	int:ING1
Interaction	CD44 interactions	PRDM10 TRRAP EP300 HDAC2	7.57e-04	239	35	4	int:CD44
Interaction	GNE interactions	SMARCAD1 EP300 HDAC2	7.75e-04	104	35	3	int:GNE
Interaction	NR6A1 interactions	TRRAP EP300	7.90e-04	24	35	2	int:NR6A1
Interaction	EID2 interactions	EP300 HDAC2	7.90e-04	24	35	2	int:EID2
Interaction	GFI1 interactions	PRDM5 HDAC2	7.90e-04	24	35	2	int:GFI1
Interaction	ELP2 interactions	HUWE1 EP300 HDAC2	7.97e-04	105	35	3	int:ELP2
Interaction	EIF3L interactions	CHD4 HUWE1 EP300 HDAC2	8.17e-04	244	35	4	int:EIF3L
Interaction	TAF6 interactions	CHD4 TRRAP EP300 HDAC2	8.30e-04	245	35	4	int:TAF6
GeneFamily	PHD finger proteins\|NuRD complex	CHD4 HDAC2	7.62e-05	12	20	2	1305
GeneFamily	Zinc fingers C2H2-type\|PR/SET domain family	PRDM10 PRDM5	1.57e-04	17	20	2	1197
GeneFamily	Phospholipases	PLD1 PLD2	9.75e-04	42	20	2	467
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	BNC2 PRDM10 ZNF225 PRDM5	7.19e-03	718	20	4	28
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_1\|343B / Donor, Lineage, Cell class and subclass (all cells)	SMG9 BNC2 TOGARAM1 TRRAP	5.13e-06	155	33	4	a4ff78e2efc6fe9a513bb2b64e5848f2ce65a09f
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SMG9 BNC2 TOGARAM1 TRRAP	9.88e-06	183	33	4	807d64deaf4e50dccf6f831f88578a6d903c1421
ToppCell	3'_v3-bone_marrow-Hematopoietic_Erythro-Mega-Mega-Mast\|bone_marrow / Manually curated celltypes from each tissue	ISYNA1 ZNF225 PAQR7 HDAC2	1.01e-05	184	33	4	030d5ef5e44e4d973862128fe01f7e8ef0092a06
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	SMG9 BNC2 TOGARAM1 TRRAP	1.05e-05	186	33	4	76cbc3610aedf8c19c17ad5faf6ef5e8980b6af5
Drug	2-(hydroxymethyl)-1,4-benzodioxan	PLD1 PLD2	6.49e-06	3	34	2	CID000019314
Drug	sialylphospholipid	PLD1 PLD2	6.49e-06	3	34	2	CID000515706
Drug	Froxiprostum	PLD1 PLD2	1.30e-05	4	34	2	CID006434698
Drug	SCH 49210	PLD1 PLD2	3.23e-05	6	34	2	CID000158548
Drug	NSC339555	PLD1 PLD2 RPS6KA2 MAP3K1	4.50e-05	133	34	4	CID000433902
Drug	Choline	PLD1 PLD2	4.52e-05	7	34	2	DB00122
Disease	developmental cardiac valvular defect (implicated_via_orthology)	PLD1 PLD2	1.29e-06	2	34	2	DOID:0080633 (implicated_via_orthology)
Disease	Adenocarcinoma of large intestine	UBR5 TRRAP EP300 RPS6KA2	4.53e-06	96	34	4	C1319315
Disease	rectum cancer (is_implicated_in)	CHD4 MAP3K1	4.62e-05	9	34	2	DOID:1993 (is_implicated_in)
Disease	Cardiac Hypertrophy	PLD1 PLD2 HDAC2	1.16e-04	82	34	3	C1383860
Disease	Cardiomegaly	PLD1 PLD2 HDAC2	1.16e-04	82	34	3	C0018800
Disease	visual epilepsy (biomarker_via_orthology)	PLD1 PLD2 HDAC2	1.53e-04	90	34	3	DOID:11832 (biomarker_via_orthology)
Disease	hepatocellular carcinoma (is_marker_for)	SMG9 CHD4 MAP3K1 HDAC2	3.87e-04	301	34	4	DOID:684 (is_marker_for)
Disease	colon adenocarcinoma (is_implicated_in)	CHD4 UBR5	4.12e-04	26	34	2	DOID:234 (is_implicated_in)
Disease	ciliopathy (implicated_via_orthology)	RPGRIP1 TOGARAM1	9.78e-04	40	34	2	DOID:0060340 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RHRNRAPLTHKMNKM	ERVK-25	16	P61579
LPHCRTMKNVLNHMT	EP300	366	Q09472
RHRNRAPLTHKMNKM	ERVK-19	16	O71037
RHRNRAPLTHKMNKM	ERVK-8	16	Q902F8
RHRNRAPLTHKMNKM	ERVK-9	16	Q9UKH3
RLHMPMLRNNRDKDL	BNC2	496	Q6ZN30
NLHRMPMRHRKKAAD	ARMH3	421	Q5T2E6
LSRHKQHSMILVPMN	ACAD11	561	Q709F0
RHRNRAPLTHKMNKM	HERVK_113	16	P61574
RHRNRAPSSHKMNKM	ERVK-16	16	P61578
RHRNRAPLTHKMNKM	ERVK-19	16	P61572
RHRNRAPLTHKMNKM	ERVK-21	16	P61571
RHRNRAPLTHKMNKM	ERVK-6	16	Q69383
RHRNRAPLTHKMNKM	ERVK-9	16	P61573
LPPQNHMLLEHKMER	ISYNA1	496	Q9NPH2
QLSRLHMILKPFMLR	INO80	731	Q9ULG1
KMLIRHKMTHNPNRP	PRDM5	586	Q9NQX1
LHRHMLIFRLPNLQM	LRRC9	1336	Q6ZRR7
MAMAQKLSHLLPSLR	PAQR7	1	Q86WK9
RMSQKVHRKMLPSNL	HSPB9	96	Q9BQS6
KLREHMQRMHNPERE	PRDM10	686	Q9NQV6
LGQLMNMLSHPVIRR	HUWE1	3431	Q7Z6Z7
HLMVVLHTLLDPRNM	PPP4R3C	436	Q6ZMV5
MNRAPLKRSRILHMA	SLC35C1	1	Q96A29
RHRNRAPLTHKMNKM	ERVK-25	16	P61570
RHRNRAPLTHKMNKM	ERVK-6	16	Q69384
HQLLEKRSMGMQRPL	BCL9L	681	Q86UU0
RHRNRAPLTHKMNKM	ERVK-21	16	P61565
RHRNRAPLTHKMNKM	HERVK_113	16	Q902F9
MKPHRIRMTHNLLLN	HDAC2	31	Q92769
LHDMLGPHMLRRLKA	CHD4	946	Q14839
LAMAVAHRMQPHRLK	DUOXA1	266	Q1HG43
LVMRNMFSHRLPVHR	PIP4K2C	201	Q8TBX8
LREEIRMMSHLNHPN	MAP3K1	1291	Q13233
RMMSHLNHPNIIRML	MAP3K1	1296	Q13233
KDMQPHNILQRRLME	NRIP3	56	Q9NQ35
QRLSMHQRPQMHRLQ	RPGRIP1	111	Q96KN7
MQLRKMANHPLLHRQ	SMARCAD1	776	Q9H4L7
RTLMRLHPNIKVMRH	PLD1	436	Q13393
PRKLRQMHLMIDQLM	SMG9	381	Q9H0W8
RHRNRAPLTHKMNKM	ERVK-8	16	P61575
ANLNRHSMVHMREKP	ZNF225	301	Q9UK10
LETMHKMIPLLRDHL	TOGARAM1	1551	Q9Y4F4
HLPRRKRMSVAHMSL	RHBDF2	231	Q6PJF5
MLLHPNIKVMRHPDQ	PLD2	421	O14939
SRIMHMQRELHPTLL	TRRAP	3301	Q9Y4A5
NPFRMKQLRQLRMVH	TBC1D2	871	Q9BYX2
HRMLVVAEQPLHAMR	UBR5	2641	O95071
KMLHVDPHQRLTAMQ	RPS6KA2	651	Q15349