Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inositol 1,4,5 trisphosphate binding	RPH3A ITPR3	1.71e-04	14	28	2	GO:0070679
GeneOntologyMolecularFunction	methylated histone binding	CHD1 ZCWPW2 ZMYND8	2.34e-04	86	28	3	GO:0035064
GeneOntologyMolecularFunction	methylation-dependent protein binding	CHD1 ZCWPW2 ZMYND8	2.50e-04	88	28	3	GO:0140034
Domain	DAD_dom	DAAM2 DAAM1	5.19e-05	8	26	2	IPR014767
Domain	DAD	DAAM2 DAAM1	5.19e-05	8	26	2	PS51231
Domain	Drf_GBD	DAAM2 DAAM1	6.67e-05	9	26	2	PF06371
Domain	FH3_dom	DAAM2 DAAM1	6.67e-05	9	26	2	IPR010472
Domain	GTPase-bd	DAAM2 DAAM1	6.67e-05	9	26	2	IPR010473
Domain	Drf_FH3	DAAM2 DAAM1	6.67e-05	9	26	2	PF06367
Domain	Drf_FH3	DAAM2 DAAM1	6.67e-05	9	26	2	SM01139
Domain	Drf_GBD	DAAM2 DAAM1	6.67e-05	9	26	2	SM01140
Domain	GBD/FH3_dom	DAAM2 DAAM1	1.02e-04	11	26	2	IPR014768
Domain	GBD_FH3	DAAM2 DAAM1	1.02e-04	11	26	2	PS51232
Domain	FH2	DAAM2 DAAM1	1.93e-04	15	26	2	PS51444
Domain	FH2_Formin	DAAM2 DAAM1	1.93e-04	15	26	2	IPR015425
Domain	FH2	DAAM2 DAAM1	1.93e-04	15	26	2	PF02181
Domain	FH2	DAAM2 DAAM1	1.93e-04	15	26	2	SM00498
Domain	PWWP	ZCWPW2 ZMYND8	4.63e-04	23	26	2	PF00855
Domain	PWWP_dom	ZCWPW2 ZMYND8	4.63e-04	23	26	2	IPR000313
Domain	PWWP	ZCWPW2 ZMYND8	5.05e-04	24	26	2	PS50812
Domain	Znf_FYVE_PHD	TAF3 RPH3A ZMYND8	1.09e-03	147	26	3	IPR011011
Domain	Zinc_finger_PHD-type_CS	TAF3 ZMYND8	3.67e-03	65	26	2	IPR019786
Domain	PHD	TAF3 ZMYND8	4.86e-03	75	26	2	PF00628
Domain	Znf_PHD-finger	TAF3 ZMYND8	5.38e-03	79	26	2	IPR019787
Domain	PHD	TAF3 ZMYND8	6.77e-03	89	26	2	SM00249
Domain	Znf_PHD	TAF3 ZMYND8	7.07e-03	91	26	2	IPR001965
Domain	ZF_PHD_2	TAF3 ZMYND8	7.68e-03	95	26	2	PS50016
Domain	ZF_PHD_1	TAF3 ZMYND8	7.84e-03	96	26	2	PS01359
Domain	ARM-type_fold	DAAM2 DAAM1 VPS35	1.13e-02	339	26	3	IPR016024
Pubmed	Identification of chick and mouse Daam1 and Daam2 genes and their expression patterns in the central nervous system.	DAAM2 DAAM1	6.25e-07	2	28	2	15464228
Pubmed	Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2.	DAAM2 DAAM1	6.25e-07	2	28	2	38000028
Pubmed	Identification and comparative expression analyses of Daam genes in mouse and Xenopus.	DAAM2 DAAM1	1.87e-06	3	28	2	15533824
Pubmed	Novel candidate genes putatively involved in stress fracture predisposition detected by whole-exome sequencing.	NEB GRK4	1.87e-06	3	28	2	25023003
Pubmed	Interactome and Ubiquitinome Analyses Identify Functional Targets of Herpes Simplex Virus 1 Infected Cell Protein 0.	KIF5B RPL3 IGHG2 VPS35	2.95e-06	124	28	4	35516420
Pubmed	Myosin5a tail associates directly with Rab3A-containing compartments in neurons.	KIF5B RPH3A	3.75e-06	4	28	2	21349835
Pubmed	Disheveled-associated activator of morphogenesis 2 promotes invasion of colorectal cancer by activating PAK1 and promoting MMP7 expression.	DAAM2 DAAM1	3.75e-06	4	28	2	33974241
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	KIF5B NEB RPL3 VPS35 ITPR3	5.44e-06	322	28	5	26514267
Pubmed	Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1.	DAAM2 DAAM1	6.24e-06	5	28	2	11779461
Pubmed	Placental defects lead to embryonic lethality in mice lacking the Formin and PCP proteins Daam1 and Daam2.	DAAM2 DAAM1	1.74e-05	8	28	2	32353019
Pubmed	Expression of multiple formins in adult tissues and during developmental stages of mouse brain.	DAAM2 DAAM1	5.65e-05	14	28	2	26272686
Pubmed	Sequence identification of 2,375 human brain genes.	DAAM2 RPL3	6.52e-05	15	28	2	1538749
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	CHD1 KIF5B RPL3 RPH3A VPS35	1.25e-04	621	28	5	22794259
Pubmed	Atmin mediates kidney morphogenesis by modulating Wnt signaling.	DAAM2 DAAM1	1.71e-04	24	28	2	24852369
Pubmed	Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated GATA4 mutation.	SEMA4D DAAM2	2.01e-04	26	28	2	31138536
Pubmed	DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly.	DAAM2 DAAM1	2.01e-04	26	28	2	26526197
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	BDP1 NEB VPS35 ZMYND8	6.43e-04	497	28	4	36774506
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	NEB IGHG2 ITPR3	6.72e-04	214	28	3	22199357
GeneFamily	PWWP domain containing	ZCWPW2 ZMYND8	2.39e-04	22	19	2	1147
GeneFamily	PHD finger proteins	TAF3 ZMYND8	3.97e-03	90	19	2	88
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	VAV3 AGAP1	1.94e-02	206	19	2	682
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SEMA4D VAV3 NEB FRMD1	4.04e-06	167	29	4	ded4d6cccd3660662f12cf5a512de31d26325f1b
Drug	irinotecan HCl; Down 200; 100uM; MCF7; HT_HG-U133A	CHD1 VAV3 DAAM1 AGAP1 ZMYND8	2.69e-06	183	28	5	7498_DN
Disease	CFTR mutation carrier status	VAV3 FRMD1	2.39e-04	25	27	2	EFO_0021794
Disease	blood copper measurement	RPH3A ITPR3	9.61e-04	50	27	2	EFO_0007578
Disease	cognitive behavioural therapy	VAV3 NEB	1.29e-03	58	27	2	EFO_0007820
Disease	age at initiation of smoking	GRK4 ITPR3	1.67e-03	66	27	2	EFO_0021784
Disease	serum alanine aminotransferase measurement, response to combination chemotherapy	SEMA4D CPNE4	1.93e-03	71	27	2	EFO_0004735, EFO_0007965
Disease	Cleft palate, cleft lip	SEMA4D GFRAL RPH3A	2.07e-03	279	27	3	EFO_0003959, HP_0000175
Disease	thyroid stimulating hormone measurement	ATP8B3 VAV3 NEB	3.13e-03	323	27	3	EFO_0004748
Disease	mean reticulocyte volume	CHD1 NEB MAGED2 RPH3A	5.70e-03	799	27	4	EFO_0010701
Disease	insomnia measurement	AGAP1 ZMYND8 ITPR3	7.52e-03	443	27	3	EFO_0007876
Disease	coronary artery calcification	BDP1 SEMA4D AGAP1	7.85e-03	450	27	3	EFO_0004723
Disease	venous thromboembolism	FRMD1 GRK4 ITPR3	8.34e-03	460	27	3	EFO_0004286
Disease	autism spectrum disorder (implicated_via_orthology)	CHD1 ITPR3	8.50e-03	152	27	2	DOID:0060041 (implicated_via_orthology)
Disease	osteoarthritis, knee	AGAP1 ITPR3	9.16e-03	158	27	2	EFO_0004616

Protein segments in the cluster

Peptide	Gene	Start	Entry
KEKKQWKNKYAINES	BDP1	161	A6H8Y1
LNKEWKKKYVTLCDN	AGAP1	361	Q9UPQ3
IKWQYAVEKTKQKKN	FBXW10	686	Q5XX13
KEKVILCWQRKKYKT	ATP8B3	121	O60423
NYKKKDQETKRWLKN	CHD1	351	O14646
NKKCKRYFNEHWKEE	C17orf113	16	A0A1B0GUU1
YWKAKQTKQDKEKIA	ITPR3	71	Q14573
TAEQWKKKYEKEKEK	KIF5B	336	P33176
KKWQIYCSKKKEQED	DAAM2	76	Q86T65
CKVQKKDPKEWAAQY	MAGED2	461	Q9UNF1
VQWVSCEAKKKKFKE	NALF2	361	O75949
KKWQIYCSKKKDQEE	DAAM1	81	Q9Y4D1
EQKLSKYFSKDWKKE	FRMD1	111	Q8N878
KAKEKYQEWLKKKNA	CCDC34	231	Q96HJ3
CINKSDNVKEDKFKW	GFRAL	101	Q6UXV0
VQWECINPKYKAKKK	CPNE4	261	Q96A23
DWLNGKEYKCKVSNK	IGHG2	191	P01859
FKKYKEKVKWEEVDQ	GRK4	386	P32298
ETKKKQWCANCKKEA	ZMYND8	1021	Q9ULU4
QWFCPKCANKKKDKK	TAF3	906	Q5VWG9
KHWYECLKNKDKKIE	RPH3A	666	Q9Y2J0
NWHKSKKKAFTKYCK	RPL3	121	P39023
KKKAFTKYCKKWQDE	RPL3	126	P39023
TKYCKKWQDEDGKKQ	RPL3	131	P39023
SIQEYWKCVKKESIK	MICU2	406	Q8IYU8
YWKVSEDKKAKCAEK	SEMA4D	86	Q92854
QIFWEHEKEKKCKAD	CFAP210	411	Q0VFZ6
NSKVDDKWEKKCQKI	VPS35	546	Q96QK1
EKCKNKKKWYKSALQ	ZCWPW2	166	Q504Y3
EFYCKTKDLKKKWLE	VAV3	481	Q9UKW4
YKQDWEKSKAKKFDI	NEB	561	P20929