Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of postsynaptic density

DLG2 DLG4

1.27e-0411312GO:0098919
GeneOntologyMolecularFunctionstructural constituent of postsynaptic specialization

DLG2 DLG4

1.80e-0413312GO:0098879
GeneOntologyMolecularFunctionstructural constituent of postsynapse

DLG2 DLG4

1.12e-0332312GO:0099186
GeneOntologyMolecularFunctionstructural constituent of synapse

DLG2 DLG4

1.93e-0342312GO:0098918
GeneOntologyCellularComponentjuxtaparanode region of axon

DLG2 DLG4

1.39e-0412312GO:0044224
DomainMAGUK_N_PEST

DLG2 DLG4

1.60e-054312PF10608
DomainPDZ_assoc

DLG2 DLG4

1.60e-054312PF10600
DomainMAGUK_N_PEST

DLG2 DLG4

1.60e-054312SM01277
DomainDLG1

DLG2 DLG4

1.60e-054312IPR016313
DomainDLG1_PEST_dom

DLG2 DLG4

1.60e-054312IPR019590
DomainPDZ_assoc

DLG2 DLG4

1.60e-054312IPR019583
DomainGuanylate_kinase_CS

DLG2 DLG4

3.15e-0416312IPR020590
DomainGUANYLATE_KINASE_2

DLG2 DLG4

6.60e-0423312PS50052
DomainGUANYLATE_KINASE_1

DLG2 DLG4

6.60e-0423312PS00856
DomainGuanylate_kin

DLG2 DLG4

8.45e-0426312PF00625
DomainGK/Ca_channel_bsu

DLG2 DLG4

8.45e-0426312IPR008145
DomainGuanylate_kin-like_dom

DLG2 DLG4

8.45e-0426312IPR008144
DomainGuKc

DLG2 DLG4

8.45e-0426312SM00072
Domain-

SMC4 DLG2 DLG4 ZNFX1 VWA8 NLRP4

1.25e-037463163.40.50.300
DomainP-loop_NTPase

SMC4 DLG2 DLG4 ZNFX1 VWA8 NLRP4

2.39e-03848316IPR027417
Domain-

CFAP47 CEP95

6.17e-03713121.10.418.10
DomainCH-domain

CFAP47 CEP95

6.86e-0375312IPR001715
Domain-

CASP4 NLRP4

1.04e-02933121.10.533.10
DomainDEATH-like_dom

CASP4 NLRP4

1.17e-0299312IPR011029
PathwayBIOCARTA_PDZS_PATHWAY

DLG2 DLG4

3.50e-0418222M22001
PathwayREACTOME_RAS_ACTIVATION_UPON_CA2_INFLUX_THROUGH_NMDA_RECEPTOR

DLG2 DLG4

4.34e-0420222M17670
PathwayREACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION

DLG2 DLG4

4.80e-0421222M838
PathwayREACTOME_NEGATIVE_REGULATION_OF_NMDA_RECEPTOR_MEDIATED_NEURONAL_TRANSMISSION

DLG2 DLG4

4.80e-0421222M27944
PathwayREACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION

DLG2 DLG4

5.27e-0422222MM15104
PathwayREACTOME_LONG_TERM_POTENTIATION

DLG2 DLG4

5.77e-0423222M27949
PathwayREACTOME_CREB1_PHOSPHORYLATION_THROUGH_NMDA_RECEPTOR_MEDIATED_ACTIVATION_OF_RAS_SIGNALING

DLG2 DLG4

8.57e-0428222M837
PathwayREACTOME_NEUREXINS_AND_NEUROLIGINS

DLG2 DLG4

1.12e-0332222MM15326
PathwayREACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS

DLG2 DLG4

1.34e-0335222MM15109
Pubmed

Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins.

DLG2 DLG4

7.69e-0723128755482
Pubmed

Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity.

DLG2 DLG4

7.69e-07231218936077
Pubmed

An opposing function of paralogs in balancing developmental synapse maturation.

DLG2 DLG4

7.69e-07231230586380
Pubmed

Disulfide-linked head-to-head multimerization in the mechanism of ion channel clustering by PSD-95.

DLG2 DLG4

7.69e-0723129182804
Pubmed

In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93.

DLG2 DLG4

7.69e-07231220554866
Pubmed

Hypersocial behavior and biological redundancy in mice with reduced expression of PSD95 or PSD93.

DLG2 DLG4

7.69e-07231228189758
Pubmed

PSD-93 deletion inhibits Fyn-mediated phosphorylation of NR2B and protects against focal cerebral ischemia.

DLG2 DLG4

7.69e-07231224787897
Pubmed

A DLG2 deficiency in mice leads to reduced sociability and increased repetitive behavior accompanied by aberrant synaptic transmission in the dorsal striatum.

DLG2 DLG4

7.69e-07231232164788
Pubmed

Effect of PSD-95/SAP90 and/or PSD-93/chapsyn-110 deficiency on the minimum alveolar anesthetic concentration of halothane in mice.

DLG2 DLG4

7.69e-07231220460989
Pubmed

Chronic social defeat stress leads to changes of behaviour and memory-associated proteins of young mice.

DLG2 DLG4

7.69e-07231227609644
Pubmed

A brain atlas of synapse protein lifetime across the mouse lifespan.

DLG2 DLG4

2.31e-06331236202095
Pubmed

Architecture of the Mouse Brain Synaptome.

DLG2 DLG4

2.31e-06331230078578
Pubmed

Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins.

DLG2 DLG4

2.31e-06331217046693
Pubmed

Calcium-permeable AMPA receptors and silent synapses in cocaine-conditioned place preference.

DLG2 DLG4

2.31e-06331228077487
Pubmed

Distinct spatiotemporal expression of mRNAs for the PSD-95/SAP90 protein family in the mouse brain.

DLG2 DLG4

2.31e-06331210211776
Pubmed

A developmental change in NMDA receptor-associated proteins at hippocampal synapses.

DLG2 DLG4

2.31e-06331210648730
Pubmed

MAGUKs are essential, but redundant, in long-term potentiation.

DLG2 DLG4

2.31e-06331234244435
Pubmed

Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway.

DLG2 DLG4

2.31e-06331223486974
Pubmed

High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.

SMC4 ZFR ZNFX1 TRAP1 SPATS2L RPL6

3.22e-0646931637314180
Pubmed

Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains.

DLG2 DLG4

4.61e-0643128625413
Pubmed

RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease-Associated Cognitive Deficits.

DLG2 DLG4

4.61e-06431230292394
Pubmed

Expression pattern of membrane-associated guanylate kinases in interneurons of the visual cortex.

DLG2 DLG4

4.61e-06431221031555
Pubmed

Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons.

DLG2 DLG4

4.61e-06431219109503
Pubmed

Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes.

DLG2 DLG4

4.61e-06431228452394
Pubmed

Synaptic scaffold evolution generated components of vertebrate cognitive complexity.

DLG2 DLG4

4.61e-06431223201973
Pubmed

ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons.

DLG2 DLG4

7.68e-06531220089912
Pubmed

Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95.

DLG2 DLG4

7.68e-06531211134026
Pubmed

Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A.

DLG2 DLG4

7.68e-0653129786987
Pubmed

The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.

DLG2 DLG4

7.68e-06531210725395
Pubmed

Selective interaction of megalin with postsynaptic density-95 (PSD-95)-like membrane-associated guanylate kinase (MAGUK) proteins.

DLG2 DLG4

7.68e-06531212713445
Pubmed

Interaction of brain somatostatin receptors with the PDZ domains of PSD-95.

DLG2 DLG4

7.68e-06531217950729
Pubmed

Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis.

DLG2 DLG4

1.15e-05631219118189
Pubmed

PIP3-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover.

DLG2 DLG4

1.15e-05631230867511
Pubmed

Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes.

DLG2 DLG4

1.15e-05631211572861
Pubmed

Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins.

DLG2 DLG4

1.15e-05631211274188
Pubmed

Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning.

DLG2 DLG4

1.61e-05731219243221
Pubmed

CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90.

DLG2 DLG4

1.61e-0573129581762
Pubmed

Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses.

DLG2 DLG4

1.61e-05731211997254
Pubmed

Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein.

DLG2 DLG4

1.61e-05731210844022
Pubmed

Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases.

DLG2 DLG4

1.61e-0573127477295
Pubmed

Polarity protein complex Scribble/Lgl/Dlg and epithelial cell barriers.

DLG2 DLG4

2.15e-05831223397623
Pubmed

Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A.

DLG2 DLG4

2.15e-05831226609151
Pubmed

Btbd11 supports cell-type-specific synaptic function.

DLG2 DLG4

2.15e-05831237261953
Pubmed

C-terminal interactors of the AMPA receptor auxiliary subunit Shisa9.

DLG2 DLG4

2.76e-05931224498314
Pubmed

Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.

DLG2 DLG4

2.76e-05931212067714
Pubmed

Microglia ablation alleviates myelin-associated catatonic signs in mice.

DLG2 DLG4

2.76e-05931229252214
Pubmed

Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction.

DLG2 DLG4

2.76e-05931224069373
Pubmed

Binding of neuroligins to PSD-95.

DLG2 DLG4

2.76e-0593129278515
Pubmed

Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.

SMC4 RCN2 DDRGK1 ANKRD42 RPL6

3.22e-0541831532552912
Pubmed

BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.

DDRGK1 ZFR ZNFX1 TRAP1 SPATS2L RPL6

3.40e-0571131633022573
Pubmed

Loss of SynDIG1 Reduces Excitatory Synapse Maturation But Not Formation In Vivo.

DLG2 DLG4

3.44e-051031227800545
Pubmed

A cohesin-RAD21 interactome.

SMC4 TRAP1 XIRP2 RPL6

3.45e-0520831422145905
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

DDRGK1 ZFR TRAP1 RBM8A THADA SPATS2L VWA8 PREPL

3.74e-05149631832877691
Pubmed

DGKι regulates presynaptic release during mGluR-dependent LTD.

DLG2 DLG4

4.21e-051131221119615
Pubmed

SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function.

DLG2 DLG4

4.21e-051131229490264
Pubmed

NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation.

DLG2 DLG4

5.05e-051231216980967
Pubmed

Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex.

MSL1 PHF20

5.05e-051231220018852
Pubmed

MOF-associated complexes ensure stem cell identity and Xist repression.

MSL1 PHF20

5.96e-051331224842875
Pubmed

Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation.

DLG2 DLG4

6.95e-051431231712124
Pubmed

Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop.

RCN2 ZFR TRAP1 RPL6

8.19e-0526031436199071
Pubmed

Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases.

DLG2 DLG4

9.16e-051631221920314
Pubmed

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.

RCN2 NEK1 THADA SPATS2L CNOT7

1.01e-0453331525544563
Pubmed

MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair.

MSL1 PHF20

1.04e-041731220479123
Pubmed

Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins.

DLG2 DLG4

1.17e-041831219455133
Pubmed

The functional interactome landscape of the human histone deacetylase family.

SMC4 RCN2 ZFR C16orf87

1.23e-0428931423752268
Pubmed

Characterization of the zinc-induced Shank3 interactome of mouse synaptosome.

DLG2 DLG4 XIRP2

1.26e-0410931329111324
Pubmed

Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins.

DLG2 DLG4

1.30e-041931215024025
Pubmed

Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures.

DLG4 PLAT

1.30e-041931232579270
Pubmed

Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome.

DLG4 RPL6

1.45e-042031216635246
Pubmed

Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays.

DLG2 DLG4

1.92e-042331216637659
Pubmed

Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.

CFAP47 PLAT NLRP4 CNOT7

1.95e-0432631417015433
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

SMC4 RCN2 ZFR TRAP1 THADA VWA8 CNOT7

2.25e-04144031730833792
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SMC4 DDRGK1 DLG2 ZFR MSL1 TRAP1 RPL6

2.27e-04144231735575683
Pubmed

SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion.

DLG2 DLG4

2.28e-042531227480238
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

SMC4 RCN2 DDRGK1 MSL1 RBM8A SPATS2L CNOT7

2.86e-04149731731527615
Pubmed

Full function of exon junction complex factor, Rbm8a, is critical for interneuron development.

DLG4 RBM8A

2.86e-042831233154347
Pubmed

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.

DDRGK1 DLG2

3.99e-043331225064009
Pubmed

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.

ZFR TRAP1 RBM8A SPATS2L RPL6

4.40e-0473231534732716
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

DLG2 DLG4 ZNFX1 TRAP1 VWA8 RPL6

4.44e-04113931636417873
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

SMC4 RCN2 TRAP1 RBM8A PREPL RPL6

4.65e-04114931635446349
Pubmed

Quantifying domain-ligand affinities and specificities by high-throughput holdup assay.

DLG2 DLG4

4.75e-043631226053890
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

RCN2 ZFR MSL1 TRAP1 PHF20 CNOT7

4.78e-04115531620360068
Pubmed

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.

ZFR MSL1 RBM8A SPATS2L

4.96e-0441731436537216
Pubmed

Revealing A-Raf functions through its interactome.

RCN2 NEK1 RPL6

6.15e-0418731329777862
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

SMC4 RCN2 ZFR RBM8A SPATS2L RPL6

7.46e-04125731636526897
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

SMC4 ZNFX1 RPL6

7.70e-0420231333005030
Pubmed

Profiling of Parkin-binding partners using tandem affinity purification.

RCN2 RBM8A RPL6

7.81e-0420331324244333
Pubmed

The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.

TRAP1 SPATS2L VWA8

7.81e-0420331335012549
Pubmed

A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation.

RCN2 DDRGK1

8.11e-044731232160526
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

CCDC73 CEP95 RPL6

8.38e-0420831333230847
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

SMC4 ZFR RBM8A SPATS2L RPL6

8.50e-0484731535850772
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

ZFR MSL1 RBM8A PHF20 RPL6 C16orf87

8.68e-04129431630804502
Pubmed

Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.

SMC4 RCN2 TRAP1 RPL6

8.79e-0448631430940648
InteractionMRPS17 interactions

DDRGK1 ZFR ZNFX1 TRAP1 VWA8 PREPL

1.17e-06229316int:MRPS17
InteractionFMR1 interactions

DDRGK1 DLG2 DLG4 ZFR ZNFX1 RBM8A RPL6

1.37e-05536317int:FMR1
Cytoband11q14.1

DLG2 ANKRD42

3.74e-044231211q14.1
Cytoband2p21

THADA PREPL

7.88e-04613122p21
CytobandEnsembl 112 genes in cytogenetic band chr2p21

THADA PREPL

1.35e-0380312chr2p21
CytobandEnsembl 112 genes in cytogenetic band chr11q14

DLG2 ANKRD42

5.00e-03156312chr11q14
GeneFamilyCalcium voltage-gated channel subunits|Membrane associated guanylate kinases

DLG2 DLG4

2.67e-0426172904
GeneFamilyPDZ domain containing

DLG2 DLG4

8.79e-031521721220
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

DLG2 ANKRD42

1.23e-02181172694
ToppCellTransverse-T_cell-Treg|T_cell / Region, Cell class and subclass

CASP4 THADA SPATS2L C16orf87

1.02e-05197314b7a1637e4baadd657f6279f4aa96cd590c9cd8c9
ToppCellE12.5-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RCN2 CFAP47 ANKRD42

1.32e-04143313cc396b81a5e47d78c2d1cb49d682391376b63476
ToppCellNS-moderate-d_07-13-Epithelial-FOXN4+|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CFAP47 CCDC73 FAM149A

1.74e-04157313410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

CCDC73 CD96 FAM149A

1.84e-041603130f15f895f11dcabb73df79b26bfc4947f38435a7
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

CCDC73 CD96 FAM149A

1.84e-0416031350d4f867d021abcfeb49e6812bcfd5bb57466a31
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

CCDC73 CD96 FAM149A

1.84e-041603137d004bfe42707605b3851cb2319126acda4d4802
ToppCellfacs-Lung-EPCAM-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMC4 THADA CD96

1.91e-04162313b877b232f0a879a9058d81ad4730e7846484b7c3
ToppCellfacs-Lung-EPCAM-3m-Lymphocytic-CD4+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMC4 THADA CD96

1.91e-041623137384a4dd38ed68ca02a72df6deff4d34c9694ce1
ToppCelldroplet-Lung-nan-21m-Lymphocytic-Proliferating_NK|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANKRD42 DLG4 BICD1

2.05e-0416631321ba5fd755c0fb31ada42a1b5d60bede0153323d
ToppCelldroplet-Lung-nan-3m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THADA CNOT7 FAM149A

2.09e-04167313f33cef917fa733adf6d5a9a9e989a4d9fd462a8f
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SMC4 RPL6 CD96

2.28e-0417231325bf2551d698237bfd912c2ff067b1600dfb19ca
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l5|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SMC4 RPL6 CD96

2.28e-0417231309c03cc7717373f10e51281be76d53979fcb7ccd
ToppCellLeuk-UTI-Myeloid-cDC1|Leuk-UTI / Disease, Lineage and Cell Type

SPATS2L NLRP4 FAM149A

2.32e-04173313226bb8d881f32d65c60f5e4c034c6d465f8e7ba5
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SMC4 RPL6 CD96

2.32e-0417331346dbc51270cc80d6e0b7118c53cec8516b1bb508
ToppCelldroplet-Liver-LIVER_HEP-30m-Lymphocytic|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XIRP2 CD96 BICD1

2.36e-04174313ecdff386d7f0bc57c170a2c1f4deae5ba7e431b5
ToppCelldroplet-Lung-21m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ANKRD42 DLG4 BICD1

2.40e-041753136751ee4b312d7f87275f2c35e5878cfc3be3ebe3
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SMC4 RPL6 CD96

2.44e-041763133bf8ef0afad8c96f814355ead5b993d58cd1ce35
ToppCellT_cells-Tph_and_Tfh|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

THADA SPATS2L C16orf87

2.44e-0417631356c055488e34605d32562571a2fee621b47c9441
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SMC4 DDRGK1 C16orf87

2.48e-04177313f4ddf0ef0eade13b9835a5684a8dbb6f71be4697
ToppCellfacs-BAT-Fat-3m-Lymphocytic-T_cell|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMC4 THADA CD96

2.52e-041783137c101e3957ea9b0d4ebf619d1d02e7e64ae28915
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SMC4 RPL6 CD96

2.52e-04178313934a2a7b35a23b56e34d4d0ef68c271513ef1fe9
ToppCellfacs-Lung-nan-3m-Lymphocytic-CD4+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMC4 THADA CD96

2.52e-041783135ecbea15efd304057aef826ec2f385997bfaf0c9
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SMC4 RPL6 CD96

2.52e-0417831361363c3365d3e191c47be1b2a35fa8afbfa64ff2
ToppCellfacs-Lung-nan-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMC4 THADA CD96

2.52e-04178313a9a8567d8fdc0fffd612fee16b5b29ef7b1c9307
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SMC4 RPL6 CD96

2.56e-041793131309d41dbf286e9230fde6a7949e60c24d86766a
ToppCellILEUM-non-inflamed-(1)_T_(gd)|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

SMC4 RPL6 CD96

2.61e-0418031344c37644973c4fc555dc966f8cfe1f4f81fef300
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SMC4 RPL6 CD96

2.61e-0418031389d3befbea2b4c06d118d6b339545ddcc1bcfacb
ToppCellfacs-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l5|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SMC4 THADA CD96

2.61e-04180313d6e69ac2bd619557ef62ada684c37a44dc4e3f41
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l5|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SMC4 RPL6 CD96

2.65e-04181313941b1a9460c7bc87a1ab0aea21286318a1593e7a
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SMC4 RPL6 CD96

2.69e-04182313c7e07570480295e1ad3c5fbbb16b8e4df90c690d
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SMC4 RPL6 CD96

2.74e-0418331327219ad7ecdeeb9e55e39772992e14f6c497d020
ToppCellfacs-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SMC4 THADA CD96

2.74e-04183313c9cb69377883d4579c608ec8b265153fe5290e67
ToppCellfacs-SCAT-Fat-3m-Lymphocytic-T_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMC4 THADA CD96

2.78e-04184313cdacb61878e0824b8416bf365d89965797208359
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DLG2 SPATS2L BICD1

2.82e-04185313d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCelldroplet-Lung-1m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l5|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SMC4 RPL6 CD96

2.82e-041853136e08e329dfe78818f3df255476492c8b4b0b16e6
ToppCelldroplet-Lung-1m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SMC4 RPL6 CD96

2.87e-04186313b999b9bed8357083997cacf5dc64530ddedc056e
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_memory_T_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RBM8A RPL6 CD96

2.96e-0418831376f9b4276455026537a62b0e6d4883ddb68f38ba
ToppCelldroplet-Mammary_Gland-nan-3m-Lymphocytic-T_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMC4 RPL6 CD96

3.01e-04189313e00938e90f0bb0bfe17b74ef601c09079e1c2b17
ToppCellRV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

DLG2 VWA8 XIRP2

3.01e-041893135e80c47f63980904c4c1ff02c201b67b456a0974
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

THADA CD96 C16orf87

3.05e-0419031391ba66d4b56c59523485b17738e93f14bb00afa4
ToppCell(1)_T_cells-(1)_T_CD4_reg|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)

SMC4 SPATS2L C16orf87

3.05e-04190313ff42af092173c2d4472bb9a02f5a334c272e05a0
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-T_cells-gdT|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SMC4 RPL6 CD96

3.05e-04190313116314a27064d3005d950c9a9163b79ea438707b
ToppCelldroplet-Limb_Muscle-nan-3m-Lymphocytic-T_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMC4 RPL6 CD96

3.05e-04190313d00fa8eda2454c5f9eddfb0e08913a68bb0bd8fc
ToppCelldroplet-Mammary_Gland-nan-3m-Lymphocytic-T_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMC4 RPL6 CD96

3.10e-041913137943049e935c09cbda6f60ab3f09c4424a5f9d43
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PREPL CEP95 CD96

3.10e-04191313696921a4f160b6b55698652488ed781e855e5e51
ToppCellcontrol-Myeloid-Neutrophils_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

CASP4 ZNFX1 SPATS2L

3.25e-04194313267e213e8efe53aadfe553a2ca010a0e3b4b8939
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-gdT|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SMC4 RPL6 CD96

3.25e-04194313a7e1445cf7ce7de04a7a11601c66fe8c03a82db6
ToppCellHippocampus-Neuronal|Hippocampus / BrainAtlas - Mouse McCarroll V32

DLG2 DLG4 ZFR

3.25e-041943138aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCellCOVID-19-T_cells-Cycling_NK/T_cells|COVID-19 / group, cell type (main and fine annotations)

SMC4 CCDC73 CD96

3.30e-04195313764ed100c28d9bc93ee5ecabc5291c8f184d78da
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-stromal_related|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RCN2 PLAT SPATS2L

3.30e-0419531355b4030f078173b0136990fae87b6eaf44c58f33
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RCN2 PLAT SPATS2L

3.30e-0419531319347b7e8d3ea67e0fddd948078abcab9d364a2d
ToppCellCOVID-19-Epithelial_cells-Cycling_epithelial|COVID-19 / group, cell type (main and fine annotations)

RBM8A RPL6 CD96

3.34e-04196313ac55fff652bad06eab502645bf64126625763ab3
ToppCellMS-CD4-exh_CD4|MS / Condition, Cell_class and T cell subcluster

SMC4 CASP4 CD96

3.34e-04196313d0217eccaa2cbf4ce9934e9d2e0c34a7f5c1a57e
ToppCellMild-CD4+_T_activated|Mild / Disease group and Cell class

PLAT ZNFX1 SPATS2L

3.34e-04196313daa1c3322d81e649161e889e1d78451d2d425d09
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SMC4 CD96 C16orf87

3.40e-041973131ca06d6d288cb58a6e8062ebc01831e58ee5be4b
ToppCellnormal_Pleural_Fluid-T/NK_cells-Exhausted_CD8+_T|T/NK_cells / Location, Cell class and cell subclass

SMC4 CASP4 CD96

3.40e-041973132bf540fa228687a71f595a807e4a2af20588a82c
ToppCell(1)_T_cell-(15)_Treg|(1)_T_cell / shred on Cell_type and subtype

THADA SPATS2L C16orf87

3.40e-041973136e7723e8b977be35c60cc11ac7cfa4f71339441e
ToppCelllymphoid-T_cell|lymphoid / Lineage, cell class and subclass

SMC4 RPL6 CD96

3.45e-0419831341573038b34803f664a7cb5a7d05b8afdff55b58
ToppCelllymphoid-T_cell|World / Lineage, cell class and subclass

SMC4 RPL6 CD96

3.45e-04198313c427a52bc5098894c55b62d9b8545a2bbf9923fd
ToppCellCaecum-T_cell-Treg|T_cell / Region, Cell class and subclass

THADA SPATS2L C16orf87

3.45e-0419831390a2a75ca078f7088b8739795a9b396113bcbe23
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like_Prolif|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SMC4 RCN2 PLAT

3.45e-0419831306888fe2d42ac66ac12157608becd42764e0d034
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like_Prolif-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SMC4 RCN2 PLAT

3.45e-04198313cd876fba12ff30b74aa507286cb1f3a867011a92
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like_Prolif-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SMC4 RCN2 PLAT

3.45e-0419831336897e17de2e22ee6b23920ee6e60931903f3e5c
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-OPC_related|5w / Sample Type, Dataset, Time_group, and Cell type.

RCN2 RBM8A RPL6

3.55e-04200313b19a75d4f23e9685cbb6c6fa873d7726f27bd5f2
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Neuron|3m / Sample Type, Dataset, Time_group, and Cell type.

RCN2 BICD1 FAM149A

3.55e-042003133d134ae3c48ff4d1849db4fbe44ff73fb6c8c779
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-OPC-like|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SMC4 RCN2 PLAT

3.55e-0420031338e681997913fcbc93f4e1715820e53844376eab
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-OPC_related-Oligodendrocyte/OPC|5w / Sample Type, Dataset, Time_group, and Cell type.

RCN2 RBM8A RPL6

3.55e-04200313b99dc49b735430a5ac51159575b904020d861927
Diseasebenign neoplasm (implicated_via_orthology)

DLG2 DLG4

2.98e-058312DOID:0060072 (implicated_via_orthology)
Diseasefourth ventricle volume measurement

XIRP2 BICD1

1.27e-0416312EFO_0010303
Diseaseage-related hearing impairment

DLG2 DLG4 THADA CD96

3.55e-04324314EFO_0005782
Diseaseasphyxia neonatorum

ZFR THADA

5.20e-0432312EFO_1000824
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

DLG2 DLG4

1.22e-0349312DOID:0060037 (implicated_via_orthology)
Diseasesusceptibility to measles measurement

DLG2 XIRP2

1.22e-0349312EFO_0008414
Diseaseresponse to TNF antagonist

TRAP1 CD96

1.48e-0354312EFO_0004653
Diseasecarcinoma (implicated_via_orthology)

DLG2 DLG4

2.07e-0364312DOID:305 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
YEGLKHEIKRFEEET

BICD1

196

Q96G01
LEEDAVYKTHVEKDF

CASP4

286

P49662
HEEYLKLKEAFVVEE

DDRGK1

186

Q96HY6
IDENDVKYFIRHGVE

ANKRD42

336

Q8N9B4
GVQEDVDEYVKLGHE

RCN2

46

Q14257
EEDIHDKFAEYGEIK

RBM8A

86

Q9Y5S9
YEKIKAIHEDEDENI

NEK1

1206

Q96PY6
SLEEEVYHVDGKIEE

FAM149A

396

A5PLN7
VTEIHLYFEEEVKQE

NLRP4

116

Q96MN2
EKERHKLFQGYETEE

MSL1

276

Q68DK7
IQFKKHEEEGIETQY

CNOT7

121

Q9UIV1
HEEEREKQEKEIDIY

C16orf87

111

Q6PH81
EAEIHYEEQIGKIIV

CCDC73

46

Q6ZRK6
IHEKEEETEKIYRGE

CEP95

506

Q96GE4
IVEGDSFEEIYHKVK

DLG4

691

P78352
EKDIQEHKFIEAGQY

DLG2

736

Q15700
EEDHGSLEKEKYEQF

CFAP47

1506

Q6ZTR5
EIPKIHEFEYEIQFE

CFAP47

2951

Q6ZTR5
AHIEDIDYEEGKVLI

PHF20

31

Q9BVI0
VEQVKEIGDYFKQHL

THADA

1086

Q6YHU6
AEIKHFVSERKYDEE

SPATS2L

316

Q9NUQ6
EFHAEKEEIVKGDVQ

XIRP2

1471

A4UGR9
GEEEQKFEVEKYIVH

PLAT

381

P00750
KFEVEKYIVHKEFDD

PLAT

386

P00750
HDEKEGIYITNEERK

CD96

311

P40200
RHQEGEIFDTEKEKY

RPL6

226

Q02878
EVHFQKIIDKEGDDY

SMC4

161

Q9NTJ3
EEYEIINVEVKHGGF

PREPL

106

Q4J6C6
VHVVDKYQGEENDII

ZNFX1

1181

Q9P2E3
ENEHVEEDGYIKQKE

ZSWIM2

126

Q8NEG5
HDYVEEVRNDEGKVI

ZFR

566

Q96KR1
ETDIVVDHYKEEKFE

TRAP1

551

Q12931
HAIKEIVKEEADEYF

VWA8

1811

A3KMH1