Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionarylsulfatase activity

ARSF ARSK

1.71e-0414282GO:0004065
GeneOntologyMolecularFunctionsulfuric ester hydrolase activity

ARSF ARSK

2.55e-0417282GO:0008484
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

KMT2A EZH2

1.73e-0344282GO:0140938
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ETV4 ZNF630 DLX3 HIVEP2 EZH2 RFX4 ZNF557

3.32e-031459287GO:0000977
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

KMT2A EZH2

4.08e-0368282GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

KMT2A EZH2

4.20e-0369282GO:0016278
GeneOntologyMolecularFunctionhistone methyltransferase activity

KMT2A EZH2

4.44e-0371282GO:0042054
DomainSULFATASE_1

ARSF ARSK

2.70e-0417272PS00523
DomainSULFATASE_2

ARSF ARSK

2.70e-0417272PS00149
DomainSulfatase

ARSF ARSK

3.04e-0418272PF00884
DomainSulfatase_N

ARSF ARSK

3.04e-0418272IPR000917
DomainAlkaline_phosphatase_core

ARSF ARSK

9.12e-0431272IPR017850
DomainAlkaline_Pase-like_a/b/a

ARSF ARSK

9.12e-0431272IPR017849
Domain-

ARSF ARSK

9.12e-04312723.40.720.10
DomainSET

KMT2A EZH2

1.59e-0341272PF00856
DomainSET

KMT2A EZH2

2.00e-0346272SM00317
DomainSET_dom

KMT2A EZH2

2.36e-0350272IPR001214
DomainSET

KMT2A EZH2

2.36e-0350272PS50280
DomainPTPc_motif

PTPRM DUSP1

3.27e-0359272SM00404
DomainTyr_Pase_cat

PTPRM DUSP1

3.27e-0359272IPR003595
DomainTyr_Pase_AS

PTPRM DUSP1

4.96e-0373272IPR016130
DomainTYR_PHOSPHATASE_1

PTPRM DUSP1

6.83e-0386272PS00383
DomainTYR_PHOSPHATASE_2

PTPRM DUSP1

6.98e-0387272PS50056
DomainTYR_PHOSPHATASE_dom

PTPRM DUSP1

6.98e-0387272IPR000387
Domain-

PTPRM DUSP1

7.78e-03922723.90.190.10
DomainProt-tyrosine_phosphatase-like

PTPRM DUSP1

8.96e-0399272IPR029021
PathwayREACTOME_THE_ACTIVATION_OF_ARYLSULFATASES

ARSF ARSK

1.19e-0413182M663
Pubmed

MLL1:EZH2 Ratio in Uterine Secretions and Endometrial Receptivity in Patients with Endometriosis.

KMT2A EZH2

6.71e-07229236094360
Pubmed

Long non-coding RNA profiling links subgroup classification of endometrioid endometrial carcinomas with trithorax and polycomb complex aberrations.

KMT2A EZH2

2.01e-06329226431491
Pubmed

The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes.

KMT2A EZH2

4.02e-06429229754954
Pubmed

Polycomb repressive complex 2 is required for MLL-AF9 leukemia.

KMT2A EZH2

4.02e-06429222396593
Pubmed

Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic.

KMT2A EZH2

1.41e-05729221135039
Pubmed

ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency.

KMT2A EZH2

3.01e-051029220569692
Pubmed

A census of human transcription factors: function, expression and evolution.

ETV4 KMT2A DLX3 HIVEP2 EZH2 RFX4

8.85e-0590829619274049
Pubmed

Alterations in gene expression in T1 alpha null lung: a model of deficient alveolar sac development.

EFNA3 DUSP1

9.06e-051729216869965
Pubmed

Structure and evolution of the Smith-Magenis syndrome repeat gene clusters, SMS-REPs.

CCDC144CP CCDC144A

2.69e-042929211997339
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

KMT2A EZH2

3.49e-043329226864203
Pubmed

Expansion of the renal capsular stroma, ureteric bud branching defects and cryptorchidism in mice with Wilms tumor 1 gene deletion in the stromal compartment of the developing kidney.

ETV4 SLC12A3

4.63e-043829232715478
Pubmed

Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses.

ETV4 RFX4

4.88e-043929222458338
Pubmed

Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.

KMT2A EZH2

6.21e-044429224183668
Pubmed

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.

KMT2A EZH2

7.71e-044929234368113
Cytoband17q21

ETV4 DLX3

7.35e-046329217q21
Cytoband17p11.2

CCDC144CP CCDC144A

4.55e-0315929217p11.2
CytobandEnsembl 112 genes in cytogenetic band chr17p11

CCDC144CP CCDC144A

7.30e-03203292chr17p11
GeneFamilySulfatases

ARSF ARSK

1.76e-0418202410
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT2A EZH2

6.38e-0434202487
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF630 ZNF609 HIVEP2 ZNF557

7.19e-0371820428
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_1000

JPH1 ETV4 ZNF609 DDX46 EFNA3 RFX4 DUSP1 SANBR

2.84e-05986288Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_1000_k-means-cluster#4

JPH1 DDX46 EFNA3 RFX4 SANBR

3.97e-05298285Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_1000_K4
CoexpressionAtlasFacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_500_k-means-cluster#1

JPH1 RFX4 SANBR

1.15e-0472283Facebase_RNAseq_e9.5_Olfactory Placode_500_K1
DiseaseWeaver syndrome

KMT2A EZH2

8.67e-065282C0265210
Diseaseacute lymphoblastic leukemia (implicated_via_orthology)

KMT2A EZH2

1.30e-056282DOID:9952 (implicated_via_orthology)
Diseasemyelofibrosis (is_implicated_in)

KMT2A EZH2

2.42e-058282DOID:4971 (is_implicated_in)
Diseasecoagulation factor V measurement

DLX3 PAK5

1.63e-0420282EFO_0008087
Diseasecerebellum cortex volume change measurement, age at assessment

HIVEP2 PTPRM

2.78e-0426282EFO_0008007, EFO_0021497
Diseaseprostate cancer (is_marker_for)

KMT2A EZH2 DUSP1

4.31e-04156283DOID:10283 (is_marker_for)
Diseasefactor VII activating protease measurement

DLX3 ZNF609

1.25e-0355282EFO_0009368
Diseaseacute myeloid leukemia (is_implicated_in)

KMT2A EZH2

2.88e-0384282DOID:9119 (is_implicated_in)
Diseaseurinary bladder cancer (is_marker_for)

EZH2 DUSP1

4.63e-03107282DOID:11054 (is_marker_for)
Diseaseapolipoprotein A 1 measurement

KMT2A SLC12A3 RFX4 LILRA4

8.01e-03848284EFO_0004614
Diseaseadiponectin measurement

HIVEP2 RFX4

8.45e-03146282EFO_0004502

Protein segments in the cluster

PeptideGeneStartEntry
SRSDQCHHPYNYGFD

ARSF

146

P54793
HPVDYYSSYTKNCTG

ARSK

251

Q6UWY0
PYYFHGCGHVVYNNS

GLDN

366

Q6ZMI3
GCGHVVYNNSLYYHK

GLDN

371

Q6ZMI3
YYHPYSGSQEHVCQS

CCDC144CP

326

Q8IYA2
YGQTVNPYTYHHQFN

DLX3

56

O60479
LPYHHGEQCLYSSAY

ETV4

116

P43268
VYPHREEHGYTGSYN

RFX4

591

Q33E94
THPQGHSYNSYTYPR

PAK5

306

Q9P286
EHAGRYHCYYQSPAG

LILRA4

91

P59901
PSNGELHSQYHGYYV

JPH1

541

Q9HDC5
DGSSNHVYNYQPCDH

EZH2

511

Q15910
YKPTCYEHAANCYTH

MMD

21

Q15546
NDYLDIYCPHYNSSG

EFNA3

56

P52797
VSANCPNHFEGHYQY

DUSP1

206

P28562
YFHYGSVVTYHCNLG

CR1L

176

Q2VPA4
STYDDHYNRHGYNPG

CFAP107

96

Q8N1D5
YYHPYSGSQEHVCQS

CCDC144B

376

Q3MJ40
PHSQTSGSCYYHVIS

KMT2A

2126

Q03164
VVNYSCPNHYEDYVH

DDX46

691

Q7L014
YYHPYSGSQEHVCQS

CCDC144A

376

A2RUR9
HSYNLTVHYCYQVGG

PTPRM

411

P28827
TNYPGHYNFNIYHRC

PHAF1

311

Q9BSU1
FSHCQYHSETVVYPT

SANBR

411

Q6NSI8
HCTQYVRHSSDPFYT

TPH1

251

P17752
GVHRYSDVHNCSYNY

ZFAND6

171

Q6FIF0
HQSYIPYMHGYSYSQ

ZNF609

1221

O15014
TQQHSCHYGLINYYQ

SLC12A3

431

P55017
FCQHVYFTGHQNPYR

ZNF630

636

Q2M218
SSHYSIHTGEYPYEC

ZNF557

301

Q8N988
YAHTKEQTYPCYSGA

HIVEP2

1271

P31629