Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	neuronal dense core vesicle membrane	KIF1A SLC18A2	8.70e-05	6	51	2	GO:0099012
GeneOntologyCellularComponent	dense core granule membrane	KIF1A SLC18A2	2.59e-04	10	51	2	GO:0032127
Domain	-	RASA4 RASA4B	2.02e-05	3	49	2	4.10.1130.10
Domain	Rho_GTPase_activation_prot	ABR ARHGAP31 RASA4 RASA4B	8.29e-05	88	49	4	IPR008936
Domain	BTK	RASA4 RASA4B	2.40e-04	9	49	2	SM00107
Domain	ZF_BTK	RASA4 RASA4B	2.40e-04	9	49	2	PS51113
Domain	Znf_Btk_motif	RASA4 RASA4B	2.40e-04	9	49	2	IPR001562
Domain	BTK	RASA4 RASA4B	2.40e-04	9	49	2	PF00779
Domain	RasGAP	RASA4 RASA4B	6.01e-04	14	49	2	SM00323
Domain	RasGAP_CS	RASA4 RASA4B	6.01e-04	14	49	2	IPR023152
Domain	RAS_GTPASE_ACTIV_2	RASA4 RASA4B	6.93e-04	15	49	2	PS50018
Domain	RasGAP	RASA4 RASA4B	6.93e-04	15	49	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	RASA4 RASA4B	6.93e-04	15	49	2	PS00509
Domain	-	RASA4 RASA4B	7.90e-04	16	49	2	1.10.506.10
Domain	HEAT_REPEAT	PDS5B PDS5A HEATR5A	8.21e-04	70	49	3	PS50077
Domain	RasGAP_dom	RASA4 RASA4B	1.00e-03	18	49	2	IPR001936
Domain	AMP-binding_CS	ACSL3 ACSS3	2.11e-03	26	49	2	IPR020845
Domain	AMP_BINDING	ACSL3 ACSS3	2.44e-03	28	49	2	PS00455
Domain	AMP-binding	ACSL3 ACSS3	2.80e-03	30	49	2	PF00501
Domain	AMP-dep_Synth/Lig	ACSL3 ACSS3	2.80e-03	30	49	2	IPR000873
Domain	PH	ABR KIF1A RASA4 RASA4B	3.03e-03	229	49	4	PF00169
Domain	Olfact_rcpt	OR6B3 OR52A5 OR10G2 OR52E8 OR52B6	3.59e-03	393	49	5	IPR000725
Domain	Peptidase_M12B_N	ADAMTS6 ADAM18	4.70e-03	39	49	2	IPR002870
Domain	Pep_M12B_propep	ADAMTS6 ADAM18	4.70e-03	39	49	2	PF01562
Domain	C2	ABR RASA4 RASA4B	4.91e-03	131	49	3	PF00168
Domain	DISINTEGRIN_1	ADAMTS6 ADAM18	4.94e-03	40	49	2	PS00427
Domain	ADAM_MEPRO	ADAMTS6 ADAM18	4.94e-03	40	49	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS6 ADAM18	4.94e-03	40	49	2	PS50214
Domain	Reprolysin	ADAMTS6 ADAM18	4.94e-03	40	49	2	PF01421
Domain	Peptidase_M12B	ADAMTS6 ADAM18	4.94e-03	40	49	2	IPR001590
Domain	Disintegrin_dom	ADAMTS6 ADAM18	5.18e-03	41	49	2	IPR001762
Domain	C2	ABR RASA4 RASA4B	5.56e-03	137	49	3	SM00239
Domain	PH	ABR KIF1A RASA4 RASA4B	6.02e-03	278	49	4	SM00233
Domain	PH_DOMAIN	ABR KIF1A RASA4 RASA4B	6.09e-03	279	49	4	PS50003
Domain	C2	ABR RASA4 RASA4B	6.14e-03	142	49	3	PS50004
Domain	PH_domain	ABR KIF1A RASA4 RASA4B	6.17e-03	280	49	4	IPR001849
Domain	-	ABR RASA4 RASA4B	6.88e-03	148	49	3	2.60.40.150
Domain	GPCR_Rhodpsn_7TM	OR6B3 OR52A5 OR10G2 OR52E8 GPR101 OR52B6	7.85e-03	670	49	6	IPR017452
Domain	7tm_1	OR6B3 OR52A5 OR10G2 OR52E8 GPR101 OR52B6	8.24e-03	677	49	6	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR6B3 OR52A5 OR10G2 OR52E8 GPR101 OR52B6	8.71e-03	685	49	6	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR6B3 OR52A5 OR10G2 OR52E8 GPR101 OR52B6	9.07e-03	691	49	6	PS50262
Domain	C2_dom	ABR RASA4 RASA4B	9.11e-03	164	49	3	IPR000008
Domain	GPCR_Rhodpsn	OR6B3 OR52A5 OR10G2 OR52E8 GPR101 OR52B6	9.13e-03	692	49	6	IPR000276
Domain	RhoGAP	ABR ARHGAP31	1.15e-02	62	49	2	SM00324
Domain	ARM-type_fold	PDS5B UBR4 PDS5A HEATR5A	1.19e-02	339	49	4	IPR016024
Domain	RhoGAP	ABR ARHGAP31	1.19e-02	63	49	2	PF00620
Pathway	KEGG_MEDICUS_REFERENCE_ESTABLISHMENT_OF_COHESION	PDS5B PDS5A	1.80e-04	7	42	2	M47869
Pathway	REACTOME_COHESIN_LOADING_ONTO_CHROMATIN	PDS5B PDS5A	3.84e-04	10	42	2	M27178
Pathway	REACTOME_COHESIN_LOADING_ONTO_CHROMATIN	PDS5B PDS5A	3.84e-04	10	42	2	MM14892
Pathway	REACTOME_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION	PDS5B PDS5A	4.69e-04	11	42	2	M27177
Pathway	REACTOME_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION	PDS5B PDS5A	4.69e-04	11	42	2	MM14891
Pathway	REACTOME_MITOTIC_TELOPHASE_CYTOKINESIS	PDS5B PDS5A	6.62e-04	13	42	2	M27661
Pathway	REACTOME_MITOTIC_TELOPHASE_CYTOKINESIS	PDS5B PDS5A	6.62e-04	13	42	2	MM15363
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ACSL3 PDS5B RBM15 KIF1A UBR4 RPS10 GEMIN4 PDS5A MVP	4.13e-07	653	51	9	22586326
Pubmed	PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.	PDS5B PDS5A	2.11e-06	2	51	2	31757807
Pubmed	PDS5A and PDS5B in Cohesin Function and Human Disease.	PDS5B PDS5A	2.11e-06	2	51	2	34070827
Pubmed	An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.	RASA4 RASA4B	2.11e-06	2	51	2	16041389
Pubmed	PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome.	PDS5B PDS5A	2.11e-06	2	51	2	35986423
Pubmed	CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.	RASA4 RASA4B	2.11e-06	2	51	2	11448776
Pubmed	CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.	RASA4 RASA4B	6.32e-06	3	51	2	25637021
Pubmed	Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation.	POLR2B MED13	6.32e-06	3	51	2	12050112
Pubmed	Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres.	PDS5B PDS5A	6.32e-06	3	51	2	24141881
Pubmed	Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module.	PDS5B PDS5A	6.32e-06	3	51	2	28343969
Pubmed	Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.	PDS5B PDS5A	1.26e-05	4	51	2	29217591
Pubmed	Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.	RASA4 RASA4B	1.26e-05	4	51	2	16234249
Pubmed	Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.	RASA4 RASA4B	1.26e-05	4	51	2	21460216
Pubmed	PDS5 proteins regulate the length of axial elements and telomere integrity during male mouse meiosis.	PDS5B PDS5A	1.26e-05	4	51	2	32285610
Pubmed	Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates.	PDS5B PDS5A	3.15e-05	6	51	2	15837422
Pubmed	Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts.	PDS5B PDS5A	4.41e-05	7	51	2	15855230
Pubmed	Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies.	PDS5B PDS5A	4.41e-05	7	51	2	19412548
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	PDS5B RBM15 UBR4 PDS5A MED13	4.94e-05	272	51	5	31010829
Pubmed	Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization.	PDS5B PDS5A	5.87e-05	8	51	2	29867216
Pubmed	Comparative genome mapping in the sequence-based era: early experience with human chromosome 7.	RASA4 RASA4B	5.87e-05	8	51	2	10810084
Pubmed	Quantitative analysis of cohesin complex stoichiometry and SMC3 modification-dependent protein interactions.	PDS5B PDS5A	5.87e-05	8	51	2	21699228
Pubmed	Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.	PDS5B PDS5A	7.54e-05	9	51	2	17349791
Pubmed	Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression.	PDS5B PDS5A	7.54e-05	9	51	2	16682347
Pubmed	Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase.	PDS5B PDS5A	7.54e-05	9	51	2	17112726
Pubmed	Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.	PDS5B PDS5A	9.42e-05	10	51	2	22751501
Pubmed	Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis.	PDS5B PDS5A	9.42e-05	10	51	2	23242214
Pubmed	Sororin mediates sister chromatid cohesion by antagonizing Wapl.	PDS5B PDS5A	9.42e-05	10	51	2	21111234
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	RBM15 ABR ARRDC4 UBR4 GEMIN4	9.57e-05	313	51	5	38270169
Pubmed	APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer.	PDS5B PDS5A	1.15e-04	11	51	2	22293751
Pubmed	Wapl controls the dynamic association of cohesin with chromatin.	PDS5B PDS5A	1.15e-04	11	51	2	17113138
Pubmed	The human olfactory receptor gene family.	OR6B3 OR52A5 OR10G2 OR11H7 OR52E8 OR52B6	1.37e-04	541	51	6	14983052
Pubmed	Calreticulin Deficiency Disturbs Ribosome Biogenesis and Results in Retardation in Embryonic Kidney Development.	RPS10 RPS10P5	1.38e-04	12	51	2	34070742
Pubmed	Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production.	CERS3 ALOXE3	1.38e-04	12	51	2	31356814
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ACSL3 PDS5B RBM15 POLR2B UBR4 RPS10 GEMIN4 PDS5A MVP	1.38e-04	1353	51	9	29467282
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR6B3 OR52A5 OR10G2 OR11H7 OR52E8	1.41e-04	340	51	5	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR6B3 OR52A5 OR10G2 OR11H7 OR52E8	1.41e-04	340	51	5	11802173
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	PDS5B POLR2B UBR4 GEMIN4 PDS5A	1.43e-04	341	51	5	32971831
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR6B3 OR52A5 OR10G2 OR11H7 OR52E8	1.47e-04	343	51	5	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR6B3 OR52A5 OR10G2 OR11H7 OR52E8	1.53e-04	346	51	5	14611657
Pubmed	Autosomal Recessive Congenital Ichthyosis	CERS3 ALOXE3	1.63e-04	13	51	2	20301593
Pubmed	A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.	POLR2B MED13	1.90e-04	14	51	2	10024883
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	ACSL3 PDS5B RBM15 KIF1A POLR2B UBR4 RPS10 GEMIN4 PDS5A	2.04e-04	1425	51	9	30948266
Pubmed	Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin.	PDS5B PDS5A	2.19e-04	15	51	2	23901111
Pubmed	Murine model indicates 22q11.2 signaling adaptor CRKL is a dosage-sensitive regulator of genitourinary development.	SLC7A13 ADAMTS6	2.50e-04	16	51	2	28439006
Pubmed	SARS-CoV-2 ORF8 Protein Induces Endoplasmic Reticulum Stress-like Responses and Facilitates Virus Replication by Triggering Calnexin: an Unbiased Study.	UBR4 RPS10	3.18e-04	18	51	2	36877072
Pubmed	PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier.	CERS3 ALOXE3	3.55e-04	19	51	2	28369476
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	PDS5B RBM15 POLR2B RPS10 PDS5A MVP	3.73e-04	652	51	6	31180492
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	PDS5B RBM15 ABR POLR2B RPS10 MED13 RBM38	3.77e-04	922	51	7	27609421
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	ACSL3 PDS5B KIF1A POLR2B UBR4 GEMIN4 PDS5A	4.29e-04	942	51	7	31073040
Pubmed	The protein interaction landscape of the human CMGC kinase group.	ACSL3 RBM15 OR6B3 RASA4 POLR2B MED13	5.23e-04	695	51	6	23602568
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	PDS5B POLR2B UBR4 RAD54B RPS10 GEMIN4 PDS5A TNFRSF10D	5.24e-04	1284	51	8	17353931
Pubmed	The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function.	POLR2B MED13	6.19e-04	25	51	2	19240132
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	PDS5B RBM15 ORC3 POLR2B UBR4 PDS5A MED13	6.64e-04	1014	51	7	32416067
Pubmed	Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.	CERS3 ALOXE3	7.23e-04	27	51	2	23096701
Pubmed	Identification of novel transcription-regulating genes expressed during murine molar development.	RPS10 RPS10P5	8.35e-04	29	51	2	22639370
Pubmed	Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.	KIF1A SLC18A2	1.15e-03	34	51	2	25915474
Pubmed	Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.	POLR2B UBR4	1.29e-03	36	51	2	35379950
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	ACSL3 PDS5B ORC3 POLR2B PDS5A	1.36e-03	560	51	5	35241646
Pubmed	SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.	PDS5B ORC3 GEMIN4	1.41e-03	150	51	3	30154076
Cytoband	15q26.3	ARRDC4 CERS3	9.65e-04	41	51	2	15q26.3
Cytoband	11p15.4	OR52A5 OR52E8 OR52B6	1.45e-03	200	51	3	11p15.4
GeneFamily	Olfactory receptors, family 52	OR52A5 OR52E8 OR52B6	2.29e-04	49	44	3	165
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA4 RASA4B	2.57e-04	10	44	2	830
GeneFamily	Acyl-CoA synthetase family	ACSL3 ACSS3	1.81e-03	26	44	2	40
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ABR KIF1A RASA4B	1.37e-02	206	44	3	682
GeneFamily	Solute carriers	SLC17A2 SLC7A13 SLC18A2 SLC4A11	1.53e-02	395	44	4	752
Disease	Congenital ichthyosis of skin	CERS3 ALOXE3	1.30e-04	11	46	2	cv:C0020758
Disease	Congenital Nonbullous Ichthyosiform Erythroderma	CERS3 ALOXE3	1.30e-04	11	46	2	C0079154
Disease	hippocampus molecular layer volume	ARRDC4 NUP210L	1.37e-03	35	46	2	EFO_0009397
Disease	hippocampal CA4 volume	ARRDC4 NUP210L	1.88e-03	41	46	2	EFO_0009396

Protein segments in the cluster

Peptide	Gene	Start	Entry
VQVLLYYLQHPPISF	ABR	831	Q12979
IYIITIDGQPYTLHL	ADAM18	46	Q9Y3Q7
LTYLEHYQLTIPIRV	ADAMTS6	36	Q9UKP5
IIRVDYSLAVYIHIP	ARRDC4	286	Q8NCT1
YPVHIYRLLTTGTIE	RAD54B	761	Q9Y620
ETVLPSSYYQPLVHL	RASA4	261	O43374
QYLQPLPLTHYELVT	RBM15	536	Q96T37
PTLIQRTYGLTPHYI	RBM38	131	Q9H0Z9
LLPEYVVPYTIHLLA	PDS5B	986	Q9NTI5
LLPEYVVPYMIHLLA	PDS5A	996	Q29RF7
ETVLPSSYYQPLVHL	RASA4B	261	C9J798
IVEQVPYPDLLHLYS	ELF4	36	Q99607
VYYSHPVVSSVPLLR	HMX3	341	A6NHT5
HPIYKLLLPHTRYTL	ALOXE3	431	Q9BYJ1
IPPYIHILLSNLYLL	OR52A5	271	Q9H2C5
YVHILLASLYVVIPP	OR52B6	291	Q8NGF0
SVDRYLSIIHPLSYP	GPR101	126	Q96P66
FIIRIPPYHYIHVLD	MVP	6	Q14764
LIITYVPYFLTHITL	LRRC8B	271	Q6P9F7
LVFVKPSHLYVTIPY	CERS3	31	Q8IU89
PLYYVHVEPTLSLII	HEATR5A	966	Q86XA9
LIPVYIHVLPPETFL	FAT3	2691	Q8TDW7
HILLLSAPPVLFVVY	GJD3	81	Q8N144
LLHLIYLTTPYDLVS	HELQ	866	Q8TDG4
YLSNLLYPVPLVHRV	KIF1A	856	Q12756
LIPSHDIYLLVGTYI	NUP210L	256	Q5VU65
LIYSVVTPVLNPLIY	OR11H7	276	Q8NGC8
YTVVTPLLNPLIYTL	OR10G2	281	Q8NGC3
YLLPPETQPLHEVVY	ORC3	566	Q9UBD5
YIHIILANLYVVVPP	OR52E8	276	Q6IFG1
LLLKEQTAYPPTHYI	SLC4A11	791	Q8NBS3
TLAHVLYYPQKPLVT	POLR2B	746	P30876
YVISTVTRPVPLEHY	SKIV2L	476	Q15477
HAVTYPPAIVVYIID	MED13	1631	Q9UHV7
VLYTVITPILNPLIY	OR6B3	276	Q8NGW1
IHFLISLYTILTYIP	ACSL3	26	O95573
VPVLSEHPLYILYTS	ACSS3	286	Q9H6R3
LASPYHYLIIIVVLV	TNFRSF10D	206	Q9UBN6
IQYLRDYLHLPPEIV	RPS10	76	P46783
SQYLRDYLHLPPEIV	RPS10P5	76	Q9NQ39
IILTYLPTYISTLLH	SLC17A2	291	O00624
AFLHVLYTLVIPIRY	STEAP4	301	Q687X5
QELPPSHYRTLEYLI	ARHGAP31	136	Q2M1Z3
VIPLVKSPNVHYVYV	SLC7A13	411	Q8TCU3
YNIVLIPKIVLFPHY	ZDHHC21	26	Q8IVQ6
IGSVSLVIYYSLLHP	XKR5	306	Q6UX68
YYFTVLALHILPPEQ	UBR4	5036	Q5T4S7
LLTVVVPIIPSYLYS	SLC18A2	36	Q05940
IYPVTYILPITLHLL	PIGM	181	Q9H3S5
IYVEVSILHRTDPYL	ZP4	346	Q12836
HVPYSLEYIQFVPLL	GEMIN4	886	P57678
LLVIGTTLHVYPDLY	NALCN	456	Q8IZF0