Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR51T1 OR2L8 DRD2 DRD3 OR2B2 HTR6 GPR32 GPR42 OR10J6P MRGPRE OR2L5 OR10Q1 ADGRB2 OR8H1 OR2H1 GRM3 OR10T2 CHRM3 OR10R2 OR14A16 OR2L2 OPRPN ADORA2B OR10AG1 ADRA2C LPAR6 SMO OR4K5 TAS2R31 OR10S1 OR4K3 OR4K15 GPR119

1.28e-1588413933GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR51T1 OR2L8 DRD2 DRD3 OR2B2 EPHA6 HTR6 GPR32 GPR42 OR10J6P MRGPRE OR2L5 OR10Q1 ADGRB2 OR8H1 OR2H1 GRM3 OR10T2 CHRM3 OR10R2 OR14A16 OR2L2 OPRPN ADORA2B LIFR OR10AG1 ADRA2C LPAR6 SMO OR4K5 TAS2R31 OR10S1 OR4K3 OR4K15 GPR119

7.26e-12135313935GO:0004888
GeneOntologyMolecularFunctionolfactory receptor activity

OR51T1 OR2L8 OR2B2 OR10J6P OR2L5 OR10Q1 OR8H1 OR2H1 OR10T2 OR10R2 OR14A16 OR2L2 OR10AG1 OR4K5 OR10S1 OR4K3 OR4K15

8.60e-0943113917GO:0004984
GeneOntologyMolecularFunctiontransporter activity

CACNA1D TMEM30B SPNS1 ABCC4 SLC16A9 SLC2A8 PIEZO1 COX8A ATP9B PKD1L2 SLC30A3 SLC7A11 SLC18B1 SLC66A1 CACNG3 SLC22A18 SLC15A2 KCNJ6 NPC1L1 ABCB11 SLC45A2 TMC5 SLC24A1 SLC23A2 SLC4A5 MFSD10

8.05e-07128913926GO:0005215
GeneOntologyMolecularFunctionactive transmembrane transporter activity

ABCC4 SLC16A9 SLC2A8 COX8A SLC30A3 SLC7A11 SLC18B1 SLC22A18 SLC15A2 ABCB11 SLC45A2 SLC24A1 SLC23A2 SLC4A5

6.26e-0647713914GO:0022804
GeneOntologyMolecularFunctiontransmembrane transporter activity

CACNA1D SPNS1 ABCC4 SLC16A9 SLC2A8 PIEZO1 COX8A PKD1L2 SLC30A3 SLC7A11 SLC18B1 SLC66A1 CACNG3 SLC22A18 SLC15A2 KCNJ6 ABCB11 SLC45A2 TMC5 SLC24A1 SLC23A2 SLC4A5 MFSD10

6.74e-06118013923GO:0022857
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC16A9 SLC2A8 SLC30A3 SLC7A11 SLC18B1 SLC22A18 SLC15A2 SLC45A2 SLC24A1 SLC23A2 SLC4A5

7.34e-0629613911GO:0015291
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

ABCC4 SLC16A9 SLC2A8 SLC7A11 SLC66A1 SLC22A18 ABCB11 SLC23A2 SLC4A5 MFSD10

4.00e-0529313910GO:0008514
GeneOntologyMolecularFunctionsymporter activity

SLC16A9 SLC22A18 SLC15A2 SLC45A2 SLC24A1 SLC23A2 SLC4A5

8.75e-051501397GO:0015293
GeneOntologyMolecularFunctiondopamine neurotransmitter receptor activity, coupled via Gi/Go

DRD2 DRD3

1.44e-0431392GO:0001591
GeneOntologyMolecularFunctioncarbohydrate transmembrane transporter activity

SLC2A8 ABCB11 SLC45A2 SLC23A2

2.05e-04421394GO:0015144
GeneOntologyMolecularFunctionABC-type bile acid transporter activity

ABCC4 ABCB11

2.86e-0441392GO:0015432
GeneOntologyMolecularFunctionATPase-coupled organic acid transmembrane transporter activity

ABCC4 ABCB11

2.86e-0441392GO:0033283
GeneOntologyMolecularFunctionATPase-coupled monocarboxylic acid transmembrane transporter activity

ABCC4 ABCB11

2.86e-0441392GO:0033285
GeneOntologyMolecularFunctionATPase-coupled carboxylic acid transmembrane transporter activity

ABCC4 ABCB11

2.86e-0441392GO:0033284
GeneOntologyMolecularFunctiondopamine neurotransmitter receptor activity

DRD2 DRD3

4.75e-0451392GO:0004952
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1D PIEZO1 COX8A PKD1L2 SLC30A3 SLC18B1 CACNG3 SLC15A2 KCNJ6 SLC45A2 SLC24A1 SLC23A2 SLC4A5

7.58e-0466413913GO:0008324
GeneOntologyMolecularFunctionmonosaccharide transmembrane transporter activity

SLC2A8 SLC45A2 SLC23A2

8.54e-04271393GO:0015145
GeneOntologyMolecularFunctionsugar transmembrane transporter activity

SLC2A8 SLC45A2 SLC23A2

1.06e-03291393GO:0051119
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

CACNA1D PIEZO1 COX8A PKD1L2 SLC30A3 SLC18B1 CACNG3 SLC15A2 KCNJ6 SLC45A2 TMC5 SLC24A1 SLC23A2 SLC4A5

1.29e-0379313914GO:0015075
GeneOntologyMolecularFunctionalcohol transmembrane transporter activity

ABCC4 MFSD10

1.31e-0381392GO:0015665
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

CACNA1D COX8A PKD1L2 SLC30A3 SLC18B1 CACNG3 SLC15A2 KCNJ6 SLC45A2 SLC24A1 SLC23A2 SLC4A5

1.47e-0362713912GO:0022890
GeneOntologyMolecularFunctionmodified amino acid transmembrane transporter activity

ABCC4 SLC16A9 SLC7A11

1.55e-03331393GO:0072349
GeneOntologyMolecularFunctiontripeptide transmembrane transporter activity

ABCC4 SLC15A2

1.68e-0391392GO:0042937
GeneOntologyMolecularFunctionATPase-coupled lipid transmembrane transporter activity

ABCC4 ABCB11

1.68e-0391392GO:0034040
GeneOntologyMolecularFunctionxenobiotic transmembrane transporter activity

ABCC4 SLC22A18 ABCB11

1.69e-03341393GO:0042910
GeneOntologyMolecularFunctionodorant binding

OR10Q1 OR8H1 OR10T2 OR10R2 OR14A16

1.96e-031271395GO:0005549
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

CACNA1D ABCC4 COX8A PKD1L2 SLC30A3 SLC18B1 CACNG3 SLC15A2 KCNJ6 SLC45A2 SLC24A1 SLC23A2 SLC4A5

2.47e-0375813913GO:0015318
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR51T1 CACNA1D OR2L8 DRD2 DRD3 OR2B2 HTR6 GPR32 GPR42 OR10J6P MRGPRE OR2L5 OR10Q1 ADGRB2 OR8H1 DGKH OR2H1 GRM3 OR10T2 CHRM3 OR10R2 OR14A16 OR2L2 OPRPN ADORA2B OR10AG1 ADRA2C LPAR6 SMO OR4K5 TAS2R31 OR10S1 OR4K3 OR4K15 GPR119

5.55e-12139513835GO:0007186
GeneOntologyBiologicalProcessdetection of stimulus

OR51T1 OR2L8 OR2B2 OR10J6P PIEZO1 OR2L5 OR10Q1 NAIP OR8H1 TLR9 OR2H1 PKD1L2 OR10T2 OR10R2 OR14A16 OR2L2 OR10AG1 LPO SMO OR4K5 TAS2R31 OR10S1 OR4K3 OR4K15

8.00e-1172213824GO:0051606
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR51T1 OR2L8 OR2B2 OR10J6P OR2L5 OR10Q1 OR8H1 TLR9 OR2H1 OR10T2 OR10R2 OR14A16 OR2L2 OR10AG1 LPO OR4K5 TAS2R31 OR10S1 OR4K3 OR4K15

3.30e-1052413820GO:0009593
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR51T1 OR2L8 OR2B2 OR10J6P OR2L5 OR10Q1 OR8H1 OR2H1 OR10T2 OR10R2 OR14A16 OR2L2 OR10AG1 LPO OR4K5 TAS2R31 OR10S1 OR4K3 OR4K15

6.18e-1048513819GO:0050907
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR51T1 OR2L8 DRD2 OR2B2 OR10J6P OR2L5 OR10Q1 OR8H1 OR2H1 OR10T2 OR10R2 OR14A16 OR2L2 OR10AG1 LPO OR4K5 TAS2R31 OR10S1 OR4K3 OR4K15

6.97e-1054713820GO:0007606
GeneOntologyBiologicalProcesssensory perception

OR51T1 CACNA1D OR2L8 DRD2 OR2B2 OR10J6P OR2L5 OR10Q1 OR8H1 OR2H1 GRM3 OR10T2 OR10R2 OR14A16 SPX OR2L2 OPRPN OR10AG1 LPO SLC45A2 OR4K5 TAS2R31 OR10S1 SLC24A1 OR4K3 OR4K15 OTOG

2.15e-09107213827GO:0007600
GeneOntologyBiologicalProcesssensory perception of smell

OR51T1 OR2L8 DRD2 OR2B2 OR10J6P OR2L5 OR10Q1 OR8H1 OR2H1 OR10T2 OR10R2 OR14A16 OR2L2 OR10AG1 OR4K5 OR10S1 OR4K3 OR4K15

2.19e-0946513818GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR51T1 OR2L8 OR2B2 OR10J6P OR2L5 OR10Q1 OR8H1 OR2H1 OR10T2 OR10R2 OR14A16 OR2L2 OR10AG1 OR4K5 OR10S1 OR4K3 OR4K15

4.96e-0943213817GO:0050911
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR51T1 OR2L8 OR2B2 OR10J6P OR2L5 OR10Q1 OR8H1 OR2H1 OR10T2 OR10R2 OR14A16 OR2L2 OR10AG1 LPO OR4K5 TAS2R31 OR10S1 OR4K3 OR4K15

1.22e-0858213819GO:0050906
GeneOntologyBiologicalProcessadenylate cyclase-modulating G protein-coupled receptor signaling pathway

CACNA1D DRD2 DRD3 HTR6 GPR42 ADGRB2 GRM3 CHRM3 ADORA2B ADRA2C GPR119

3.64e-0628613811GO:0007188
GeneOntologyBiologicalProcessregulation of catecholamine secretion

DRD2 DRD3 HTR6 GPR42 ADORA2B ADRA2C

5.74e-06671386GO:0050433
GeneOntologyBiologicalProcessorganic cation transport

SLC16A9 HTR6 GPR42 SLC18B1 SLC66A1 ADORA2B SLC22A18 ADRA2C

6.04e-061451388GO:0015695
GeneOntologyBiologicalProcessmonoamine transport

DRD2 DRD3 HTR6 GPR42 SLC18B1 ADORA2B ADRA2C

1.31e-051161387GO:0015844
GeneOntologyBiologicalProcesscatecholamine secretion

DRD2 DRD3 HTR6 GPR42 ADORA2B ADRA2C

1.50e-05791386GO:0050432
GeneOntologyBiologicalProcessorganic hydroxy compound transport

ABCC4 DRD2 DRD3 HTR6 GPR42 SLC18B1 ADORA2B ADRA2C NPC1L1 ABCB11 MFSD10

2.98e-0535813811GO:0015850
GeneOntologyBiologicalProcesstripeptide transmembrane transport

ABCC4 SLC7A11 SLC15A2

3.40e-05101383GO:0035443
GeneOntologyBiologicalProcessorganic anion transport

ABCC4 DRD2 DRD3 SLC16A9 HTR6 SLC2A8 SLC7A11 SLC66A1 SPX ABCB11 SLC23A2 SLC4A5 MFSD10

4.34e-0551513813GO:0015711
GeneOntologyBiologicalProcesscatecholamine transport

DRD2 DRD3 HTR6 GPR42 ADORA2B ADRA2C

4.55e-05961386GO:0051937
GeneOntologyBiologicalProcessregulation of adenylate cyclase activity

CACNA1D DRD2 DRD3 GRM3 ADORA2B

4.67e-05591385GO:0045761
GeneOntologyBiologicalProcesstripeptide transport

ABCC4 SLC7A11 SLC15A2

7.98e-05131383GO:0042939
GeneOntologyBiologicalProcessregulation of cyclase activity

CACNA1D DRD2 DRD3 GRM3 ADORA2B

9.94e-05691385GO:0031279
GeneOntologyBiologicalProcessregulation of lyase activity

CACNA1D DRD2 DRD3 GRM3 ADORA2B

1.30e-04731385GO:0051339
GeneOntologyBiologicalProcessoligopeptide transmembrane transport

ABCC4 SLC7A11 SLC15A2

1.86e-04171383GO:0035672
GeneOntologyBiologicalProcessregulation of amine transport

DRD2 DRD3 HTR6 GPR42 ADORA2B ADRA2C

1.97e-041251386GO:0051952
GeneOntologyBiologicalProcessnegative regulation of adenylate cyclase activity

DRD2 DRD3 GRM3

2.22e-04181383GO:0007194
GeneOntologyBiologicalProcessnegative regulation of cyclase activity

DRD2 DRD3 GRM3

2.63e-04191383GO:0031280
GeneOntologyBiologicalProcessnegative regulation of dopamine receptor signaling pathway

DRD2 DRD3

2.64e-0441382GO:0060160
GeneOntologyBiologicalProcessphospholipase C-activating G protein-coupled receptor signaling pathway

DRD2 DRD3 GPR32 CHRM3 OPRPN LPAR6

2.75e-041331386GO:0007200
GeneOntologyBiologicalProcessadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

DRD2 DRD3 GPR42 GRM3 CHRM3

2.81e-04861385GO:0007193
GeneOntologyBiologicalProcessamine transport

DRD2 DRD3 HTR6 GPR42 ADORA2B ADRA2C

3.23e-041371386GO:0015837
GeneOntologyBiologicalProcessphenol-containing compound metabolic process

DRD2 DRD3 SLC7A11 KCNJ6 DIO3 SLC45A2

3.91e-041421386GO:0018958
GeneOntologyBiologicalProcessnegative regulation of lyase activity

DRD2 DRD3 GRM3

4.11e-04221383GO:0051350
GeneOntologyBiologicalProcessoligopeptide import across plasma membrane

SLC7A11 SLC15A2

4.39e-0451382GO:0140205
GeneOntologyBiologicalProcessdipeptide import across plasma membrane

SLC7A11 SLC15A2

4.39e-0451382GO:0140206
GeneOntologyBiologicalProcesscarboxylic acid transport

ABCC4 DRD2 DRD3 SLC16A9 HTR6 SLC7A11 SLC66A1 SPX ABCB11 SLC23A2

4.46e-0441013810GO:0046942
GeneOntologyBiologicalProcessorganic acid transport

ABCC4 DRD2 DRD3 SLC16A9 HTR6 SLC7A11 SLC66A1 SPX ABCB11 SLC23A2

4.63e-0441213810GO:0015849
GeneOntologyBiologicalProcessoligopeptide transport

ABCC4 SLC7A11 SLC15A2

4.70e-04231383GO:0006857
GeneOntologyBiologicalProcessregulation of sensory perception of pain

GRM3 SPX OPRPN

4.70e-04231383GO:0051930
GeneOntologyBiologicalProcessregulation of sensory perception

GRM3 SPX OPRPN

5.35e-04241383GO:0051931
GeneOntologyBiologicalProcessacid secretion

DRD2 DRD3 HTR6 ABCB11

5.76e-04571384GO:0046717
GeneOntologyBiologicalProcessadenylate cyclase-activating adrenergic receptor signaling pathway

DRD2 DRD3 ADRA2C

6.05e-04251383GO:0071880
GeneOntologyBiologicalProcessadenylate cyclase-inhibiting dopamine receptor signaling pathway

DRD2 DRD3

6.55e-0461382GO:0007195
GeneOntologyBiologicalProcessregulation of norepinephrine secretion

GPR42 ADORA2B ADRA2C

6.81e-04261383GO:0014061
GeneOntologyBiologicalProcessnorepinephrine secretion

GPR42 ADORA2B ADRA2C

8.49e-04281383GO:0048243
GeneOntologyBiologicalProcessxenobiotic transport

ABCC4 SLC22A18 SLC15A2 ABCB11

8.93e-04641384GO:0042908
Domain7tm_1

OR51T1 OR2L8 DRD2 DRD3 OR2B2 HTR6 GPR32 GPR42 MRGPRE OR2L5 OR10Q1 OR8H1 OR2H1 OR10T2 CHRM3 OR10R2 OR14A16 OR2L2 ADORA2B OR10AG1 ADRA2C LPAR6 OR4K5 OR10S1 OR4K15 GPR119

4.11e-1267713826PF00001
DomainG_PROTEIN_RECEP_F1_1

OR51T1 OR2L8 DRD2 DRD3 OR2B2 HTR6 GPR32 GPR42 MRGPRE OR2L5 OR10Q1 OR8H1 OR2H1 OR10T2 CHRM3 OR10R2 OR14A16 OR2L2 ADORA2B OR10AG1 ADRA2C LPAR6 OR4K5 OR10S1 OR4K15 GPR119

5.35e-1268513826PS00237
DomainG_PROTEIN_RECEP_F1_2

OR51T1 OR2L8 DRD2 DRD3 OR2B2 HTR6 GPR32 GPR42 MRGPRE OR2L5 OR10Q1 OR8H1 OR2H1 OR10T2 CHRM3 OR10R2 OR14A16 OR2L2 ADORA2B OR10AG1 ADRA2C LPAR6 OR4K5 OR10S1 OR4K15 GPR119

6.50e-1269113826PS50262
DomainGPCR_Rhodpsn

OR51T1 OR2L8 DRD2 DRD3 OR2B2 HTR6 GPR32 GPR42 MRGPRE OR2L5 OR10Q1 OR8H1 OR2H1 OR10T2 CHRM3 OR10R2 OR14A16 OR2L2 ADORA2B OR10AG1 ADRA2C LPAR6 OR4K5 OR10S1 OR4K15 GPR119

6.71e-1269213826IPR000276
DomainGPCR_Rhodpsn_7TM

OR51T1 OR2L8 DRD2 DRD3 OR2B2 HTR6 GPR32 MRGPRE OR2L5 OR10Q1 OR8H1 OR2H1 OR10T2 CHRM3 OR10R2 OR14A16 OR2L2 ADORA2B OR10AG1 ADRA2C LPAR6 OR4K5 OR10S1 OR4K15 GPR119

2.09e-1167013825IPR017452
DomainOlfact_rcpt

OR51T1 OR2L8 OR2B2 OR2L5 OR10Q1 OR8H1 OR2H1 OR10T2 OR10R2 OR14A16 OR2L2 OR10AG1 OR4K5 OR10S1 OR4K15

2.23e-0739313815IPR000725
DomainMFS_dom

SPNS1 SLC16A9 SLC2A8 SLC18B1 SLC22A18 SLC15A2 SLC45A2 MFSD10

6.91e-061341388IPR020846
DomainMFS_1

SPNS1 SLC16A9 SLC18B1 SLC22A18 SLC45A2 MFSD10

2.25e-05771386PF07690
DomainMFS

SPNS1 SLC16A9 SLC18B1 SLC22A18 SLC45A2 MFSD10

2.25e-05771386IPR011701
DomainMFS

SPNS1 SLC16A9 SLC2A8 SLC18B1 SLC22A18 MFSD10

1.51e-041081386PS50850
Domain7TM_GPCR_Srsx

DRD2 DRD3 HTR6 CHRM3 ADORA2B ADRA2C

1.84e-041121386SM01381
DomainHEAT

STK36 TNPO2 HEATR1 UTP20

4.31e-04481384PF02985
DomainDopamine_rcpt

DRD2 DRD3

5.34e-0451382IPR000929
PathwayREACTOME_SENSORY_PERCEPTION

OR51T1 CACNA1D OR2L8 OR2B2 OR2L5 OR10Q1 OR8H1 OR2H1 OR10T2 OR10R2 OR14A16 OR2L2 OR10AG1 OR4K5 TAS2R31 OR10S1 SLC24A1 OR4K3 OR4K15 OTOG

1.14e-086369820M41834
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR51T1 OR2L8 OR2B2 OR2L5 OR10Q1 OR8H1 OR2H1 OR10T2 OR10R2 OR14A16 OR2L2 OR10AG1 OR4K5 OR10S1 OR4K3 OR4K15

2.65e-084179816M4072
PathwayWP_GPCRS_NONODORANT

DRD2 DRD3 HTR6 GPR42 ADGRB2 GRM3 CHRM3 OPRPN ADORA2B ADRA2C LPAR6 SMO GPR119

3.70e-082669813MM15843
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR51T1 OR2L8 OR2B2 OR10Q1 OR8H1 OR2H1 OR10T2 OR10R2 OR14A16 OR2L2 OR10AG1 OR4K5 OR10S1 OR4K15

4.67e-073899814M14091
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

DRD2 DRD3 OR2B2 HTR6 GPR32 GPR42 OR2H1 CHRM3 ADORA2B ADRA2C LPAR6

1.85e-062609811M39397
PathwayWP_MONOAMINE_GPCRS

DRD2 DRD3 HTR6 CHRM3 ADRA2C

2.16e-0631985MM15871
PathwayWP_MONOAMINE_GPCRS

DRD2 DRD3 HTR6 CHRM3 ADRA2C

2.98e-0633985M39585
PathwayREACTOME_AMINE_LIGAND_BINDING_RECEPTORS

DRD2 DRD3 HTR6 CHRM3 ADRA2C

1.02e-0542985M5868
PathwayREACTOME_AMINE_LIGAND_BINDING_RECEPTORS

DRD2 DRD3 HTR6 CHRM3 ADRA2C

1.02e-0542985MM14971
PathwayREACTOME_GPCR_LIGAND_BINDING

DRD2 DRD3 HTR6 GPR42 GRM3 CHRM3 OPRPN ADORA2B ADRA2C LPAR6 TAS2R31

1.93e-044309811MM15160
PathwayREACTOME_DOPAMINE_RECEPTORS

DRD2 DRD3

4.72e-045982M27301
PathwayREACTOME_DOPAMINE_RECEPTORS

DRD2 DRD3

4.72e-045982MM15007
PathwayREACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS

DRD2 DRD3 HTR6 GPR42 CHRM3 OPRPN ADORA2B ADRA2C LPAR6

5.11e-04333989MM14963
PathwayKEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION

DRD2 DRD3 HTR6 GRM3 CHRM3 ADORA2B ADRA2C LPAR6

6.09e-04272988M13380
Pubmed

The human olfactory receptor gene family.

OR51T1 OR2L8 OR2B2 OR10J6P OR2L5 OR10Q1 OR8H1 OR2H1 OR10T2 OR10R2 OR14A16 OR2L2 OR10AG1 OR4K5 OR10S1 OR4K3 OR4K15

1.07e-105411431714983052
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR51T1 OR2L8 OR2B2 OR2L5 OR10Q1 OR8H1 OR2H1 OR2L2 OR10AG1 OR4K5 OR10S1 OR4K15

1.90e-083401431211875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR51T1 OR2L8 OR2B2 OR2L5 OR10Q1 OR8H1 OR2H1 OR2L2 OR10AG1 OR4K5 OR10S1 OR4K15

1.90e-083401431211802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR51T1 OR2L8 OR2B2 OR2L5 OR10Q1 OR8H1 OR2H1 OR2L2 OR10AG1 OR4K5 OR10S1 OR4K15

2.09e-083431431232295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR51T1 OR2L8 OR2B2 OR2L5 OR10Q1 OR8H1 OR2H1 OR2L2 OR10AG1 OR4K5 OR10S1 OR4K15

2.30e-083461431214611657
Pubmed

Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.

DRD2 DRD3 GRM3 CHRM3 ADRA2C

1.17e-0645143521041608
Pubmed

Spatiotemporal regulation of GLI target genes in the mammalian limb bud.

TMEM30B DRD3 PKDCC OR2H1 SLC66A1 TMTC1 SMO SPARCL1

2.46e-06207143826238476
Pubmed

Pharmacogenetics of risperidone therapy in autism: association analysis of eight candidate genes with drug efficacy and adverse drug reactions.

DRD2 DRD3 HTR6

3.75e-068143319997080
Pubmed

Pharmacogenetics and olanzapine treatment: CYP1A2*1F and serotonergic polymorphisms influence therapeutic outcome.

DRD2 DRD3 HTR6

3.75e-068143319636338
Pubmed

N-linked Glycosylation on the N-terminus of the dopamine D2 and D3 receptors determines receptor association with specific microdomains in the plasma membrane.

DRD2 DRD3

1.68e-052143225289757
Pubmed

Toward predicting drug-induced liver injury: parallel computational approaches to identify multidrug resistance protein 4 and bile salt export pump inhibitors.

ABCC4 ABCB11

1.68e-052143225735837
Pubmed

Dopamine receptor D2 and D3 gene variants are not associated with the antidepressant effect of total sleep deprivation in bipolar depression.

DRD2 DRD3

1.68e-052143212834818
Pubmed

Mapping the landscape of human dopamine D2/3 receptors with [11C]raclopride.

DRD2 DRD3

1.68e-052143231444615
Pubmed

Homology modeling of dopamine D2 and D3 receptors: molecular dynamics refinement and docking evaluation.

DRD2 DRD3

1.68e-052143222970199
Pubmed

Association of novelty seeking scores and striatal dopamine D₂/D₃ receptor availability of healthy volunteers: single photon emission computed tomography with ¹²³i-iodobenzamide.

DRD2 DRD3

1.68e-052143220970071
Pubmed

Palmitoylation on the carboxyl terminus tail is required for the selective regulation of dopamine D2 versus D3 receptors.

DRD2 DRD3

1.68e-052143227349735
Pubmed

Association study of dopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD.

DRD2 DRD3

1.68e-052143211425949
Pubmed

Cortical dopamine D2/D3 receptors and verbal memory in man.

DRD2 DRD3

1.68e-052143220188195
Pubmed

DRD3 (dopamine receptor D3) but not DRD2 activates autophagy through MTORC1 inhibition preserving protein synthesis.

DRD2 DRD3

1.68e-052143231538542
Pubmed

Striatal dopamine D₂/D₃ receptor binding in pathological gambling is correlated with mood-related impulsivity.

DRD2 DRD3

1.68e-052143222776462
Pubmed

Association study of tardive dyskinesia and twelve DRD2 polymorphisms in schizophrenia patients.

DRD2 DRD3

1.68e-052143216959057
Pubmed

Fluorescent ligands for dopamine D2/D3 receptors.

DRD2 DRD3

1.68e-052143233318558
Pubmed

[123I]epidepride binding to cerebellar dopamine D2/D3 receptors is displaceable: implications for the use of cerebellum as a reference region.

DRD2 DRD3

1.68e-052143217175177
Pubmed

Dopamine D2 (DAD2) and dopamine D3 (DAD3) receptor gene polymorphisms and treatment outcome in alcohol dependence.

DRD2 DRD3

1.68e-052143212811641
Pubmed

Association Study Between DRD2, DRD3 Genetic Polymorphisms and Adverse Reactions in Chinese Patients on Amisulpride Treatment.

DRD2 DRD3

1.68e-052143239187246
Pubmed

Dopamine D2/3 Binding Potential Modulates Neural Signatures of Working Memory in a Load-Dependent Fashion.

DRD2 DRD3

1.68e-052143230478031
Pubmed

Association study of dopamine D2 and D3 receptor gene polymorphisms with cocaine dependence.

DRD2 DRD3

1.68e-052143216094250
Pubmed

Extrastriatal dopamine D 2/3 receptor density and distribution in drug-naive schizophrenic patients.

DRD2 DRD3

1.68e-052143212740603
Pubmed

Striatal and extrastriatal D2/D3-receptor-binding properties of ziprasidone: a positron emission tomography study with [18F]Fallypride and [11C]raclopride (D2/D3-receptor occupancy of ziprasidone).

DRD2 DRD3

1.68e-052143219011428
Pubmed

Mice lacking dopamine D2 and D3 receptors exhibit differential activation of prefrontal cortical neurons during tasks requiring attention.

DRD2 DRD3

1.68e-052143215537671
Pubmed

Association of DRD2 and DRD3 polymorphisms with Parkinson's disease in a multiethnic consortium.

DRD2 DRD3

1.68e-052143221663922
Pubmed

Frontal D2/3 Receptor Availability in Schizophrenia Patients Before and After Their First Antipsychotic Treatment: Relation to Cognitive Functions and Psychopathology.

DRD2 DRD3

1.68e-052143226819282
Pubmed

Association of the DRD2 and DRD3 polymorphisms with response to pramipexole in Parkinson's disease patients.

DRD2 DRD3

1.68e-052143219396436
Pubmed

Dopamine D2/3 receptor availability and amphetamine-induced dopamine release in obesity.

DRD2 DRD3

1.68e-052143224785761
Pubmed

Potentiation of the D2 mutant motor phenotype in mice lacking dopamine D2 and D3 receptors.

DRD2 DRD3

1.68e-052143210391470
Pubmed

Clinical and pharmacogenetic determinants for the discontinuation of non-ergoline dopamine agonists in Parkinson's disease.

DRD2 DRD3

1.68e-052143219669131
Pubmed

Elevation of dopamine induced by cigarette smoking: novel insights from a [11C]-+-PHNO PET study in humans.

DRD2 DRD3

1.68e-052143223954846
Pubmed

Latent-Profile Analysis Reveals Behavioral and Brain Correlates of Dopamine-Cognition Associations.

DRD2 DRD3

1.68e-052143229028935
Pubmed

Positive association of dopamine D2 receptor polymorphism with bipolar affective disorder in a European Multicenter Association Study of affective disorders.

DRD2 DRD3

1.68e-052143211857579
Pubmed

Functional homomers and heteromers of dopamine D2L and D3 receptors co-exist at the cell surface.

DRD2 DRD3

1.68e-052143222291025
Pubmed

Relationship of frontal D(2/3) binding potentials to cognition: a study of antipsychotic-naive schizophrenia patients.

DRD2 DRD3

1.68e-052143222338593
Pubmed

[¹¹C]-(+)-PHNO PET imaging of dopamine D(2/3) receptors in Parkinson's disease with impulse control disorders.

DRD2 DRD3

1.68e-052143225641350
Pubmed

Neurons exhibiting dopamine D2 receptor immunoreactivity in the substantia nigra of the mutant weaver mouse.

DRD2 KCNJ6

1.68e-052143210051229
Pubmed

Postnatal ontogeny of dopamine D3 receptors in the mouse brain: autoradiographic evidence for a transient cortical expression.

DRD2 DRD3

1.68e-05214328836575
Pubmed

A shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D2/3 receptor densities.

DRD2 DRD3

1.68e-052143239300138
Pubmed

Striatal dopamine D2/3 receptor availability increases after long-term bariatric surgery-induced weight loss.

DRD2 DRD3

1.68e-052143227184782
Pubmed

Interaction between serotonin transporter and dopamine D2/D3 receptor radioligand measures is associated with harm avoidant symptoms in anorexia and bulimia nervosa.

DRD2 DRD3

1.68e-052143223154100
Pubmed

Variability in Action Selection Relates to Striatal Dopamine 2/3 Receptor Availability in Humans: A PET Neuroimaging Study Using Reinforcement Learning and Active Inference Models.

DRD2 DRD3

1.68e-052143232083297
Pubmed

Posterior dopamine D2/3 receptors and brain network functional connectivity.

DRD2 DRD3

1.68e-052143228700819
Pubmed

Decreased c-fos responses to dopamine D(1) receptor agonist stimulation in mice deficient for D(3) receptors.

DRD2 DRD3

1.68e-052143210506202
Pubmed

DRD2/ANKK1 Taq1A polymorphism (rs1800497) has opposing effects on D2/3 receptor binding in healthy controls and patients with major depressive disorder.

DRD2 DRD3

1.68e-052143223683269
Pubmed

Effects of the DRD3 Ser9Gly polymorphism on aripiprazole efficacy in schizophrenic patients as modified by clinical factors.

DRD2 DRD3

1.68e-052143219302829
Pubmed

Cerebral morphology and dopamine D2/D3 receptor distribution in humans: a combined [18F]fallypride and voxel-based morphometry study.

DRD2 DRD3

1.68e-052143219457373
Pubmed

Signaling pathways leading to phosphorylation of Akt and GSK-3β by activation of cloned human and rat cerebral D₂and D₃ receptors.

DRD2 DRD3

1.68e-052143220952497
Pubmed

G protein coupling and ligand selectivity of the D2L and D3 dopamine receptors.

DRD2 DRD3

1.68e-052143218218829
Pubmed

Alpha-synuclein aggregation and cell death triggered by energy deprivation and dopamine overload are counteracted by D2/D3 receptor activation.

DRD2 DRD3

1.68e-052143218410503
Pubmed

Prolonged treatment with pramipexole promotes physical interaction of striatal dopamine D3 autoreceptors with dopamine transporters to reduce dopamine uptake.

DRD2 DRD3

1.68e-052143225511804
Pubmed

Dopamine D2 receptors preferentially regulate the development of light responses of the inner retina.

DRD2 DRD3

1.68e-052143225393815
Pubmed

The dopamine D2 receptors in high-affinity state and D3 receptors in schizophrenia: a clinical [11C]-(+)-PHNO PET study.

DRD2 DRD3

1.68e-052143218987627
Pubmed

Roles of conserved intracellular sequences regions for the proper expression of dopamine D(2) and D(3) receptors.

DRD2 DRD3

1.68e-052143218481021
Pubmed

The candidate gene approach in alcoholism: are there gender-specific differences?

DRD2 DRD3

1.68e-052143214628173
Pubmed

Comparative studies of molecular mechanisms of dopamine D2 and D3 receptors for the activation of extracellular signal-regulated kinase.

DRD2 DRD3

1.68e-052143215102843
Pubmed

The role of bile acid retention and a common polymorphism in the ABCB11 gene as host factors affecting antiviral treatment response in chronic hepatitis C.

ABCB11 IFNL3

1.68e-052143220723035
Pubmed

Exploring personality traits related to dopamine D2/3 receptor availability in striatal subregions of humans.

DRD2 DRD3

1.68e-052143226944295
Pubmed

Dopamine Receptor Signaling in MIN6 β-Cells Revealed by Fluorescence Fluctuation Spectroscopy.

DRD2 DRD3

1.68e-052143227508444
Pubmed

Effects of smoking on D₂/D₃ striatal receptor availability in alcoholics and social drinkers.

DRD2 DRD3

1.68e-052143223649848
Pubmed

Chimeric D2/D3 dopamine receptors efficiently inhibit adenylyl cyclase in HEK 293 cells.

DRD2 DRD3

1.68e-05214328666994
Pubmed

Association of variants in DRD2 and GRM3 with motor and cognitive function in first-episode psychosis.

DRD2 GRM3

1.68e-052143224682224
Pubmed

NME3 binds to phosphatidic acid and mediates PLD6-induced mitochondrial tethering.

PLD6 NME3

1.68e-052143237584589
Pubmed

[11 C]raclopride positron emission tomography study of dopamine-D2/3 receptor binding in patients with severe major depressive episodes before and after electroconvulsive therapy and compared to control subjects.

DRD2 DRD3

1.68e-052143231943514
Pubmed

Examining the Effects of Sodium Ions on the Binding of Antagonists to Dopamine D2 and D3 Receptors.

DRD2 DRD3

1.68e-052143227379794
Pubmed

Striatal dopamine D2/3 receptor binding following dopamine depletion in subjects at Ultra High Risk for psychosis.

DRD2 DRD3

1.68e-052143222591910
Pubmed

In vivo mesolimbic D2/3 receptor binding predicts posttherapeutic clinical responses in restless legs syndrome: a positron emission tomography study.

DRD2 DRD3

1.68e-052143222234337
Pubmed

Up-regulation of dopamine D(2)L mRNA levels in the ventral tegmental area and dorsal striatum of amphetamine-sensitized C57BL/6 mice: role of Ca(v)1.3 L-type Ca(2+) channels.

CACNA1D DRD2

1.68e-052143217026527
Pubmed

Association between DRD2 and DRD3 gene polymorphisms and gastrointestinal symptoms induced by levodopa therapy in Parkinson's disease.

DRD2 DRD3

1.68e-052143227779245
Pubmed

No association of dopamine receptor sensitivity in vivo with genetic predisposition for alcoholism and DRD2/DRD3 gene polymorphisms in alcohol dependence.

DRD2 DRD3

1.68e-052143216759339
Pubmed

-141C Ins/Del polymorphism of the dopamine D2 receptor gene is associated with schizophrenia in a Spanish population.

DRD2 DRD3

1.68e-052143218496209
Pubmed

The effect of haloperidol on D2 dopamine receptor subtype mRNA levels in the brain.

DRD2 DRD3

1.68e-05214328313980
Pubmed

Association of dopamine D2/3 receptor binding potential measured using PET and [11C]-(+)-PHNO with post-mortem DRD2/3 gene expression in the human brain.

DRD2 DRD3

1.68e-052143232818617
Pubmed

The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors.

DRD2 DRD3

1.68e-052143229337986
Pubmed

Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain.

DRD2 DRD3

1.68e-052143222573693
Pubmed

New roles for dopamine D2 and D3 receptors in pancreatic beta cell insulin secretion.

DRD2 DRD3

1.68e-052143230626912
Pubmed

D2/D3 dopamine receptor binding with [F-18]fallypride correlates of executive function in medication-naïve patients with schizophrenia.

DRD2 DRD3

1.68e-052143228576546
Pubmed

Cigarette Use and Striatal Dopamine D2/3 Receptors: Possible Role in the Link between Smoking and Nicotine Dependence.

DRD2 DRD3

1.68e-052143227634830
Pubmed

Contribution of functional dopamine D2 and D3 receptor variants to motor and non-motor symptoms of early onset Parkinson's disease.

DRD2 DRD3

1.68e-052143233039854
Pubmed

Activity, non-selective attention and emotionality in dopamine D2/D3 receptor knock-out mice.

DRD2 DRD3

1.68e-052143211864730
Pubmed

A preliminary study of dopamine D2/3 receptor availability and social status in healthy and cocaine dependent humans imaged with [(11)C](+)PHNO.

DRD2 DRD3

1.68e-052143226164205
Pubmed

D3 dopamine autoreceptors do not activate G-protein-gated inwardly rectifying potassium channel currents in substantia nigra dopamine neurons.

DRD3 KCNJ6

1.68e-052143212843272
Pubmed

Dopamine D2/D3 receptor stimulation fails to promote dopaminergic neurogenesis of murine and human midbrain-derived neural precursor cells in vitro.

DRD2 DRD3

1.68e-052143217784836
Pubmed

Exploring regulation and function of dopamine D3 receptors in alcohol use disorder. A PET [11C]-(+)-PHNO study.

DRD2 DRD3

1.68e-052143234349232
Pubmed

Pharmacological characterization of 2-methoxy-N-propylnorapomorphine's interactions with D2 and D3 dopamine receptors.

DRD2 DRD3

1.68e-052143219217026
Pubmed

Early expression of D3 dopamine receptors in murine embryonic development.

DRD2 DRD3

1.68e-05214328601467
Pubmed

Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.

DRD2 DRD3 HTR6 CHRM3 ADORA2B ADRA2C LPAR6

2.02e-05200143718240029
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

SPNS1 DRD2 HTR6 SLC2A8 PAQR6 SLC18B1 CHRM3 PDIA6 TM9SF2 KCNJ6 SMO MFSD10

3.33e-056971431228298427
Pubmed

Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum.

DRD2 DRD3

5.02e-053143218644790
Pubmed

Association of functional variants in the dopamine D2-like receptors with risk for gambling behaviour in healthy Caucasian subjects.

DRD2 DRD3

5.02e-053143220452395
Pubmed

Association of dopamine D(3) receptors with actin-binding protein 280 (ABP-280).

DRD2 DRD3

5.02e-053143211911837
Pubmed

Association between dopamine receptor gene polymorphisms and effects of risperidone treatment: A systematic review and meta-analysis.

DRD2 DRD3

5.02e-053143230103286
Pubmed

Specific V gene usage in anti-phosphorylcholine IgE antibodies.

IGLV7-46 IGLV7-43

5.02e-05314328247027
Pubmed

Restricted immunoglobulin variable region (Ig V) gene expression accompanies secondary rearrangements of light chain Ig V genes in mouse plasmacytomas.

IGLV7-46 IGLV7-43

5.02e-053143210562316
GeneFamilyOlfactory receptors, family 10

OR10J6P OR10Q1 OR10T2 OR10R2 OR10AG1 OR10S1

2.68e-06661086157
GeneFamilySolute carriers

SLC16A9 SLC2A8 SLC30A3 SLC7A11 SLC18B1 SLC22A18 SLC15A2 SLC45A2 SLC24A1 SLC23A2 SLC4A5

2.44e-0539510811752
GeneFamilyDopamine receptors

DRD2 DRD3

3.49e-0451082181
GeneFamilyOlfactory receptors, family 2

OR2L8 OR2B2 OR2L5 OR2H1 OR2L2

5.83e-041131085149
GeneFamilyG protein-coupled receptors, Class A orphans

GPR32 GPR42 MRGPRE GPR119

1.22e-03781084262
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

EPHA6 GRM3 SLC7A11 ADORA2B SLC15A2 ABCB11 SPARCL1

3.87e-062001437d0812817ef99608994193787a62d39adeb2070ca
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

EPHA6 GRM3 SLC7A11 ADORA2B SLC15A2 ABCB11 SPARCL1

3.87e-062001437cd54ddf1919c98e84b7e4aba85b374fc8b407206
DrugOlanzapine

DRD2 DRD3 HTR6 CHRM3 ADRA2C

3.67e-07251385DB00334
DrugZiprasidone

DRD2 DRD3 HTR6 CHRM3 ADRA2C

3.67e-07251385DB00246
DrugAripiprazole

DRD2 DRD3 HTR6 CHRM3 ADRA2C

3.67e-07251385DB01238
DrugClozapine

DRD2 DRD3 HTR6 CHRM3 ADRA2C

4.52e-07261385DB00363
DrugQuetiapine

DRD2 DRD3 HTR6 CHRM3 ADRA2C

4.52e-07261385DB01224
Drugbifeprunox

DRD2 DRD3 HTR6 KCNJ6

8.85e-07131384CID000208951
Drugpromazine

DRD2 DRD3 HTR6 CHRM3 SLC45A2

2.84e-06371385CID000004926
DrugPGW5 compound

DRD2 DRD3 HTR6 CHRM3

2.89e-06171384ctd:C000593032
DrugMethotrimeprazine

DRD2 DRD3 CHRM3 ADRA2C

4.67e-06191384DB01403
Drugbromperidol

DRD2 DRD3 CHRM3 SLC45A2

5.81e-06201384CID000002448
Drugpimozide

CACNA1D DRD2 DRD3 HTR6 CHRM3 CACNG3 KCNJ6

1.26e-051271387CID000016362
Drugparaxanthine

DRD2 NAIP ADORA2B KCNJ6 SLC45A2

1.73e-05531385CID000004687
DrugT15550

DRD2 DRD3 HTR6 CHRM3

1.74e-05261384CID000005454
Drugoxybutynin

DRD2 CHRM3 ABCB11

1.78e-0591383ctd:C005419
DrugRilapinum

DRD2 HTR6 CHRM3

1.78e-0591383CID006446980
Drugfluperlapine

DRD2 DRD3 HTR6 CHRM3

2.03e-05271384CID000049381
DrugYohimbine

DRD2 DRD3 ADRA2C

2.53e-05101383DB01392
Drugtenilapine

DRD2 HTR6 CHRM3

2.53e-05101383CID006450478
DrugProtriptyline hydrochloride [1225-55-4]; Down 200; 13.4uM; MCF7; HT_HG-U133A

MAN2C1 SRCAP CHRM3 ADRA2C NFRKB WDFY3 SLC24A1 SLC23A2

2.67e-0519613885438_DN
Drugxanomeline

DRD2 DRD3 HTR6 CHRM3

3.58e-05311384CID000060809
DrugSulpiride

DRD2 DRD3

3.65e-0521382DB00391
DrugN-n-propyl-N-phenylethyl-4(3-hydroxyphenyl)ethylamine hydrochloride

DRD2 DRD3

3.65e-0521382ctd:C016868
Drug5-methoxy-1-methyl-2-(n-propylamino)tetralin

DRD2 DRD3

3.65e-0521382ctd:C051171
DrugCGS 15855A

DRD2 DRD3

3.65e-0521382ctd:C051347
Drug(5,6-dimethoxyindan-2-yl)dipropylamine

DRD2 DRD3

3.65e-0521382ctd:C086335
DrugDomperidone

DRD2 DRD3

3.65e-0521382DB01184
DrugUH 232

DRD2 DRD3

3.65e-0521382ctd:C045971
Drug4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrzolo(3,4-g)quinoline

DRD2 DRD3

3.65e-0521382ctd:C416545
Drug3-(3-cyanophenyl)-N-n-propylpiperidine

DRD2 DRD3

3.65e-0521382ctd:C094012
Drugiodosulpride

DRD2 DRD3

3.65e-0521382ctd:C045105
Drugfluoroclebopride

DRD2 DRD3

3.65e-0521382ctd:C083673
DrugGR 218231

DRD2 DRD3

3.65e-0521382ctd:C408390
DrugN-(4-(2-(4-(3-cyano-5-trifluoromethylphenyl)piperazin-1-yl)ethyl)cyclohexyl)-3-pyridinesulfonic amide

DRD2 DRD3

3.65e-0521382ctd:C539157
DrugPiribedil

DRD2 DRD3

3.65e-0521382ctd:D010891
DrugAC1L31N6

DRD2 DRD3

3.65e-0521382CID000132830
Drugsongorine

STK36 DRD2

3.65e-0521382CID000120706
Drugoctoclothepin

DRD2 DRD3 HTR6

4.61e-05121383CID000001238
DrugChlorprothixene

DRD2 DRD3 CHRM3

4.61e-05121383DB01239
Drugmesoridazine

DRD2 DRD3 HTR6 CHRM3

4.61e-05331384CID000004078
DrugDCG-IV

GRM3 SLC30A3 ADORA2B KCNJ6 ART5

5.84e-05681385CID000115114
Drugdiphenidol

DRD2 DRD3 CHRM3

5.96e-05131383CID000003055
Drugmolindone

DRD2 DRD3 HTR6 CHRM3

6.55e-05361384CID000023897
Drugbenzotropine mesylate

DRD2 DRD3 HTR6 CHRM3

7.31e-05371384CID000002344
DrugLisuride

DRD2 DRD3 ADRA2C

7.55e-05141383DB00589
DrugPramipexole

DRD2 DRD3 ADRA2C

7.55e-05141383DB00413
DrugRopinirole

DRD2 DRD3 ADRA2C

7.55e-05141383DB00268
DrugRisperidone

DRD2 DRD3 ADRA2C

7.55e-05141383DB00734
Drugcitalopram

CACNA1D DRD2 DRD3 TFAP2D HTR6 KCNJ6

9.22e-051201386CID000002771
DrugCabergoline

DRD2 DRD3 ADRA2C

9.40e-05151383DB00248
DrugApomorphine

DRD2 DRD3 ADRA2C

9.40e-05151383DB00714
DrugOPC-4392

DRD2 DRD3 HTR6

9.40e-05151383CID000163839
Drugaripiprazole

DRD2 DRD3 HTR6 CHRM3 KCNJ6

9.95e-05761385CID000060795
Drug(1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate)

DRD2 DRD3

1.09e-0431382ctd:C461261
DrugDP-6OH-3CA

DRD2 DRD3

1.09e-0431382CID000086146
DrugNeuriplege

DRD2 DRD3

1.09e-0431382CID000065750
Drug7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan

DRD2 DRD3

1.09e-0431382ctd:C090812
Drugfecapentaene-12

CHUK SDHA

1.09e-0431382CID006437067
Drug7-hydroxy-2-N,N-dipropylaminotetralin

DRD2 DRD3

1.09e-0431382ctd:C031349
Drug3-N-methylspiperone

DRD2 DRD3

1.09e-0431382ctd:C039167
Drugquinelorane

DRD2 DRD3

1.09e-0431382ctd:C047726
DrugFLA908

DRD2 DRD3

1.09e-0431382CID000129516
DrugSB-277011

DRD2 DRD3

1.09e-0431382CID005311096
DrugDCHAPS

DRD2 DRD3

1.09e-0431382CID000129392
Drugnafadotride

DRD2 DRD3

1.09e-0431382ctd:C097285
DrugBP 897

DRD2 DRD3

1.09e-0431382ctd:C120565
Drugiodoethylspiperone

DRD2 DRD3

1.09e-0431382CID000131222
DrugSaphris

DRD2 DRD3 HTR6 CHRM3

1.10e-04411384CID000163091
Drugclonidine

DRD2 DRD3 HTR6 COX8A ADORA2B LPAR6 KCNJ6 ART5

1.11e-042401388CID000002803
Drugquinolinic acid

DRD2 DRD3 GRM3 ADORA2B LIFR NUDT6 SLC23A2

1.13e-041791387CID000001066
DrugAC1N8H7N

ABCC4 TNPO2 KCNJ6 ABCB11 SLC45A2

1.13e-04781385CID004318740
Drugthioridazine

DRD2 DRD3 HTR6 CHRM3 KCNJ6

1.20e-04791385CID000005452
DrugPaliperidone

DRD2 DRD3 ADRA2C

1.39e-04171383DB01267
DrugPergolide

DRD2 DRD3 ADRA2C

1.39e-04171383DB01186
DrugBromocriptine

DRD2 DRD3 ADRA2C

1.66e-04181383DB01200
Drugbaclofen

CACNA1D DRD2 DRD3 GRM3 ADORA2B KCNJ6 ART5

1.68e-041911387CID000002284
Drugloxapine

DRD2 DRD3 HTR6 CHRM3

1.73e-04461384CID000003964
Drugchlorpromazine hydrochloride; Up 200; 1uM; MCF7; HT_HG-U133A

PAQR6 SLC30A3 CHRM3 SBF1 NFRKB SLC24A1 SLC23A2

1.91e-0419513876977_UP
DrugRP 62203

DRD2 DRD3 HTR6

1.97e-04191383CID000060785
Drughaloperidol; Up 200; 10uM; MCF7; HT_HG-U133A

SLC30A3 SLC7A11 CHRM3 OPRPN SBF1 WDFY3 TMC5

2.03e-0419713877003_UP
Drugaspirin, USP; Up 200; 100uM; HL60; HT_HG-U133A

PECR DRD2 ISOC1 SLC7A11 PCNX2 SLC22A18 WDFY3

2.10e-0419813871145_UP
Drugidazoxan

DRD2 DRD3 HTR6 ADORA2B ART5

2.10e-04891385CID000054459
Drugclofluperol

DRD2 DRD3

2.17e-0441382CID000025293
DrugPimozide

DRD2 DRD3

2.17e-0441382DB01100
DrugNCQ-469

DRD2 DRD3

2.17e-0441382CID000127915
Drugspectramide

DRD2 DRD3

2.17e-0441382CID000130377
DrugAmisulpride

DRD2 DRD3

2.17e-0441382DB06288
Drugsarizotan

DRD2 DRD3

2.17e-0441382ctd:C443959
DrugCinnarizine

DRD2 ABCB11

2.17e-0441382ctd:D002936
Drug3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol

DRD2 DRD3

2.17e-0441382ctd:C062458
DrugSKF83959

DRD2 DRD3

2.17e-0441382CID000133538
Drugzotepine

DRD2 DRD3 HTR6 CHRM3

2.22e-04491384CID000005736
DrugDoxepin

DRD2 CHRM3 ADRA2C

2.30e-04201383DB01142
DrugBaclofen

ABCC4 DRD3 KCNJ6

2.30e-04201383ctd:D001418
DrugLY 171555

DRD2 DRD3 GRM3 ADORA2B KCNJ6 ART5

2.32e-041421386CID000001257
Drugsertindole

DRD2 DRD3 HTR6 CHRM3

2.40e-04501384CID000060149
Drugperlapine

DRD2 DRD3 HTR6

2.67e-04211383CID000016106
DrugAC1L3NFS

MAN2C1 NPC1L1 SLC45A2

2.67e-04211383CID000092111
Drugperphenazine

DRD2 DRD3 HTR6 CHRM3

3.00e-04531384CID000004748
Drugsetoperone

DRD2 DRD3 HTR6

3.08e-04221383CID000068604
DrugAC1L1V2E

HTR6 CHUK SDHA

3.08e-04221383CID000010376
DiseaseDisruptive, Impulse Control, and Conduct Disorders

DRD2 DRD3

5.24e-0531242C0021122
DiseaseIntermittent Explosive Disorder

DRD2 DRD3

5.24e-0531242C0021776
DiseaseMood Disorders

CACNA1D DRD2 DRD3 HTR6 GRM3 ADRA2C

7.99e-051681246C0525045
Diseaseheroin dependence (biomarker_via_orthology)

DRD2 DRD3

1.74e-0451242DOID:9976 (biomarker_via_orthology)
DiseaseCognition Disorders

ABCC4 DRD2 DRD3

5.49e-04381243C0009241
Diseasecystic fibrosis (implicated_via_orthology)

ABCC4 ABCB11

6.19e-0491242DOID:1485 (implicated_via_orthology)
DiseaseRecurrent depression

DRD2 DRD3

6.19e-0491242C0221480
DiseaseDelirium

DRD2 DRD3

7.71e-04101242C0011206
DiseaseGastrointestinal Stromal Sarcoma

STK36 SMO SDHA

1.03e-03471243C3179349
DiseaseLenticulostriate Disorders

DRD2 DRD3

1.12e-03121242C0750951
DiseaseExtrapyramidal Disorders

DRD2 DRD3

1.12e-03121242C0015371
Diseasenicotine dependence (implicated_via_orthology)

DRD2 DRD3

1.12e-03121242DOID:0050742 (implicated_via_orthology)
DiseaseBasal Ganglia Diseases

DRD2 DRD3

1.12e-03121242C0004782
DiseaseGastrointestinal Stromal Tumors

STK36 SMO SDHA

1.23e-03501243C0238198
DiseaseDrug habituation

ABCC4 DRD2 CSMD3 SLC45A2

1.43e-031151244C0013170
DiseaseDrug abuse

ABCC4 DRD2 CSMD3 SLC45A2

1.43e-031151244C0013146
DiseasePrescription Drug Abuse

ABCC4 DRD2 CSMD3 SLC45A2

1.43e-031151244C4316881
DiseaseSubstance-Related Disorders

ABCC4 DRD2 CSMD3 SLC45A2

1.43e-031151244C0236969
DiseaseDrug Use Disorders

ABCC4 DRD2 CSMD3 SLC45A2

1.43e-031151244C0013222
DiseaseDrug Dependence

ABCC4 DRD2 CSMD3 SLC45A2

1.43e-031151244C1510472
DiseaseSubstance Dependence

ABCC4 DRD2 CSMD3 SLC45A2

1.43e-031151244C0038580
DiseaseSubstance Use Disorders

ABCC4 DRD2 CSMD3 SLC45A2

1.43e-031151244C0038586
DiseaseOrganic Mental Disorders, Substance-Induced

ABCC4 DRD2 CSMD3 SLC45A2

1.43e-031151244C0029231
DiseaseSubstance abuse problem

ABCC4 DRD2 CSMD3 SLC45A2

1.48e-031161244C0740858
DiseaseDyskinesia, Medication-Induced

DRD2 DRD3

1.77e-03151242C0751088
DiseaseDyskinesia, Drug-Induced

DRD2 DRD3

1.77e-03151242C0013386
Diseaseureidopropionic acid measurement

ARL4A OTOG

2.02e-03161242EFO_0010542
Diseasepancreatic ductal carcinoma (is_implicated_in)

HEATR1 SMO

2.02e-03161242DOID:3587 (is_implicated_in)
Diseasehydrocephalus (implicated_via_orthology)

STK36 HYDIN

2.86e-03191242DOID:10908 (implicated_via_orthology)
Diseaseelectroencephalogram measurement

DNAH3 CMYA5 PCNX2

3.78e-03741243EFO_0004357
DiseaseAmphetamine-Related Disorders

DRD2 DRD3 HTR6

3.92e-03751243C0236733
DiseaseAmphetamine Abuse

DRD2 DRD3 HTR6

3.92e-03751243C0236807
DiseaseAmphetamine Addiction

DRD2 DRD3 HTR6

3.92e-03751243C0236804
Diseasecarnitine measurement

PECR SLC16A9 RPUSD4

4.07e-03761243EFO_0010469
Diseaseworry measurement

DRD2 ZDHHC5 GRM3 CHRM3

4.12e-031541244EFO_0009589
DiseaseSchizophrenia

DRD2 DRD3 HTR6 CMYA5 GRM3 SLC30A3 LIFR DIO3 SDHA IFNL3

4.16e-0388312410C0036341
DiseaseEtat Marbre

DRD2 DRD3

4.18e-03231242C0266487

Protein segments in the cluster

PeptideGeneStartEntry
TVAACSPFVLQFLQG

NAIP

876

Q13075
AFSLQDLFPTIASGC

ADGRB2

51

O60241
LLLPFTTTSLCELGF

FAM200B

601

P0CF97
VASGLTFFLPSGAIC

HTR6

191

P50406
SEVSFSCNFPFILVG

CSMD3

3311

Q7Z407
SCNFPFILVGSSTRI

CSMD3

3316

Q7Z407
SLPLFEAFTACGFVQ

CPED1

671

A4D0V7
IPFAITISLGFCTDF

ADORA2B

61

P29275
FPNSFVTLSICSGLR

ADAM18

101

Q9Y3Q7
ILSSCIGSFFAPCLI

ADRA2C

211

P18825
KFISPSSQVFICLGL

GRM3

681

Q14832
SFALGCVNSSLNPFL

GPR32

301

O75388
CFIQFLSEPTITFGT

CHRM3

221

P20309
CPIIASLSFGATRTF

ALKBH3

201

Q96Q83
PSFQSFHIVILGLDC

ARL4A

16

P40617
SVTLLFFGGLCVAAS

CACNG3

111

O60359
SLVILCFFPFLALSG

ABCB11

901

O95342
CFFPFLALSGATQTR

ABCB11

906

O95342
DSVGRVSFPSLVCFL

CAPN13

621

Q6MZZ7
VQPGFCLYLSTTLSL

DNHD1

3716

Q96M86
SVKFNPIETFLLGSC

DCAF13

201

Q9NV06
FGTPAICAALSTFQT

TFAP2D

386

Q7Z6R9
SSTIFLVLPFTGIAC

OR2L2

201

Q8NH16
LIGSAFSVLQFLCAP

MFSD10

91

Q14728
FSVLQFLCAPLTGAT

MFSD10

96

Q14728
LCVSSFGARPVTIFS

SLC16A9

71

Q7RTY1
AFSPCTAQLTGVLLY

OR10S1

251

Q8NGN2
TCQIFLLPFCGTNTI

OR10AG1

151

Q8NH19
TLGNLTPSSTVFFCC

ISOC1

106

Q96CN7
LKPCLGINEISSSFF

NFRKB

366

Q6P4R8
SAVFNILFVIGTCSL

SLC24A1

531

O60721
QTASCLVLFPRFLGT

DIO3

41

P55073
PCVTNLNGFVSAFLF

KCNJ6

131

P48051
LGLISILCFAASTFP

SLC66A1

41

Q6ZP29
SLCTSFVGTLQYLAP

CHUK

176

O15111
QVLSFCILQLFPFTS

ATP9B

621

O43861
QFASTAPLLFNGCRS

DCAF4L1

231

Q3SXM0
NLRSLACQPISFSGF

POLD2

441

P49005
PALFSAFCGLLVALS

PCNX2

1031

A6NKB5
SSTIFLVFPFTGIAC

OR2L5

201

Q8NG80
SATIFLVFPFIGISC

OR2L8

201

Q8NGY9
SSNFLLTAFPGLECA

OR51T1

11

Q8NGJ9
ALSQLAFTVNLPFCG

OR4K3

156

Q96R72
TLSQLSFTVNLPFCG

OR4K5

156

Q8NGD3
TTSQLAFTVNLPFCG

OR4K15

156

Q8NH41
QSRFIAPAASLGFCF

NUDT6

101

P53370
FPFLLSLFCGAISQQ

PCDHGB1

16

Q9Y5G3
FINTTARVPCFLAGD

LPO

356

P22079
SVVCFLLSPAASFIT

PECR

241

Q9BY49
LTSFLLFLSARNCGP

GPR119

301

Q8TDV5
ASTCSFNPGVFVANL

GLT8D1

236

Q68CQ7
FGFRFLSCLPVTADT

LMNTD2

616

Q8IXW0
VGFFIPLILNVTCSS

LPAR6

191

P43657
FDSCIIVLGSPSFLS

MEFV

636

O15553
VVVACVNAASPFLGF

PGAP6

416

Q9HCN3
FFVPAAALNSFLCTG

PAQR6

151

Q6TCH4
FSFCVSPLLVFVNSK

DGKH

326

Q86XP1
LLLSGACTQFFGEPS

MRGPRE

156

Q86SM8
AVTVLGSLVCFPNTY

RALGAPA2

1101

Q2PPJ7
LVAATLLNFLVCFGP

GPR42

226

O15529
LFLFLLTCCPGSNSQ

IGLV7-43

6

P04211
CTFLSGFLLLAGTQD

PAAF1

286

Q9BRP4
FAIFCNASTALGPLE

PKD1L2

791

Q7Z442
QSSGFTPVFLQFLDC

SBF1

1476

O95248
ATGFFIALVATNLIC

OR10T2

151

Q8NGX3
QEIFSSPACLTGSFL

HERC5

416

Q9UII4
ILLPLQSCFGKLFSS

ABCC4

246

O15439
SLSEAICFFLGALTP

NPC1L1

751

Q9UHC9
TNLVISQGPFLYCSL

CDC45

436

O75419
NLLLSTSGPFFICET

HYDIN

1086

Q4G0P3
TFIFEGTELSLNPTC

DNAH3

1511

Q8TD57
TITCLFNDIPGFSLL

C3orf20

406

Q8ND61
VNFTGCSLPSERAIF

CMYA5

3786

Q8N3K9
SPGCLEASVTFNLFR

IFNL3

166

Q8IZI9
SASIALPLFFCAGLA

TMEM30B

31

Q3MIR4
SIFCSLPLGFFIVSS

GK

531

P32189
IFLTFVFTVSCGPSV

DEFB113

6

Q30KQ7
FGASCPVAVLSSFLT

MAN2C1

36

Q9NTJ4
AVGLTSCFVTFLLPA

COX8A

41

P10176
CLQALSGVASPFYLI

HEATR1

941

Q9H583
VLSFTISCPLLFGLN

DRD2

161

P14416
TICGSNYPLSIAFIV

SLC15A2

36

Q16348
GLFPNVYSTLVLCSL

SLC45A2

416

Q9UMX9
TFPQAVLLLFRCATG

CACNA1D

1391

Q01668
LFLFLLTCCPGSNSQ

IGLV7-46

6

A0A075B6I9
AFAVSCPLLFGFNTT

DRD3

161

P35462
SFGSPCSINSRQFLI

LIFR

1056

P42702
LAVGFLPFLTSVTLC

LINGO4

536

Q6UY18
LGLVSCTFFLAVNGL

PDIA6

6

Q15084
LSPGFVTALRALSFC

PTX4

286

Q96A99
GCVAQLFIFLALGST

OR2B2

96

Q9GZK3
LTIFANLFPAACTGA

NME3

6

Q13232
NVSCLFTFPNGTTSL

OTOG

2761

Q6ZRI0
CALVTGPYVISFINS

OR8H1

141

Q8NGG4
AFCPSFLRAGFLNSI

EPHA6

711

Q9UF33
PISLAGCTTQTFFFV

OR10J6P

91

Q8NGY7
LQLTALIFTLPFCGH

OR10Q1

161

Q8NGQ4
SLTVVNLVFSLPFCS

OR10R2

176

Q8NGX6
SFLGCSVQLFIFLSL

OR2H1

91

Q9GZK4
SFLGCVSQVFLLLSS

OR14A16

91

Q8NHC5
LFPLLGLSCSSTYIN

OR8G3P

181

P0DMU2
LCLFAFSSPQLGRAV

PLD6

96

Q8N2A8
GSLFTLVSKPFCAAA

RPUSD4

21

Q96CM3
TLGNLVPFTLTLLCF

TAS2R31

181

P59538
LTAAQIFGLLFASCQ

UTP20

2481

O75691
LVFVFLGNSSCAPQR

SPX

16

Q9BT56
LTLISGFFCTLAPSV

TMEM178B

261

H3BS89
GFCASFLLGSVLNVL

PKDCC

11

Q504Y2
SEAGFNTACVTKLFP

SDHA

81

P31040
SLSSCFGFLDPTLSL

SLC18B1

246

Q6NT16
FIFSTGLCALPVLTQ

IGLV4-3

11

A0A075B6K6
LLCSVPFVAGFAVIT

SLC2A8

101

Q9NY64
CFELTTFSFRGNPIS

PRAMEF20

376

Q5VT98
ARFFLSTLPASGECQ

SIM2

476

Q14190
FLGLLALISCFTPSE

OPRPN

6

Q99935
FTPSQVGCLFTFLAR

VPS8

826

Q8N3P4
FITPGICFSTASLVL

SRCAP

916

Q6ZRS2
TLLGAVLSFTCIPAS

SLC22A18

191

Q96BI1
SSVFHFCLLVPGLVF

SLC22A18

326

Q96BI1
STISPCFKNFLQGLL

STK36

221

Q9NRP7
FSSVIAPTLLCGFLF

ASPRV1

56

Q53RT3
SFGEISVLLQVPFTC

CNBD1

401

Q8NA66
SVLRGFCANSSLAFP

CHST12

126

Q9NRB3
SLAVPIFVALSCFGS

SLC7A11

316

Q9UPY5
SCIFLSPGTRAAFEQ

SEMA6B

551

Q9H3T3
PITTASFIAAGICFN

TMEM128

121

Q5BJH2
TAIPSELFSSFVNCL

XPO4

361

Q9C0E2
FGQFISSTLPTFAVC

WDFY3

1586

Q8IZQ1
SPFFLLLSLFLGTCA

TMTC1

201

Q8IUR5
LTCFSGTIAVPFLLA

SLC23A2

111

Q9UGH3
TTFGCRLPLFQASAF

SLC23A2

156

Q9UGH3
LDVSCNSISFVAPGF

TLR9

706

Q9NR96
FFLCLLGTAAAIPTN

SPARCL1

6

Q14515
SAPFLFLSLACARGS

SPNS1

366

Q9H2V7
FVGCIFTAELSTPFV

TLCD3A

146

Q8TBR7
CLSSVATALQSGFLP

TNPO2

586

O14787
RCALFSGPLVQAVSA

TLNRD1

246

Q9H1K6
LFCLFSGQPLIILSS

SLC4A5

566

Q9BY07
AFGAVTGLCTLFTLA

SMO

236

Q99835
DPISTFLFSICALGS

SLC30A3

266

Q99726
FLFSICALGSTAPTL

SLC30A3

271

Q99726
GATTLFFAFTCPGLS

ZDHHC5

26

Q9C0B5
VTLFFACLGFLSPAN

TM9SF2

381

Q99805
FFPSFTGVLCTLAIT

TMC5

841

Q6UXY8
FSSILVPGFFLLACI

PIEZO1

681

Q92508
TCAFAPNTLLLATGS

WDSUB1

286

Q8N9V3
ISRGFTLVSAACPFN

VEZT

231

Q9HBM0
VPLSVFRAGTLTCFV

TPGS1

176

Q6ZTW0
LCLGKAPSSSQLFLF

USP40

831

Q9NVE5
NATLFSLTTCFGAPI

ART5

196

Q96L15
SLTTCFGAPIQAFSV

ART5

201

Q96L15