Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity

INPP5B OCRL

1.85e-047602GO:0052659
GeneOntologyMolecularFunctioninositol-polyphosphate 5-phosphatase activity

INPP5B OCRL

2.46e-048602GO:0004445
GeneOntologyMolecularFunctioninositol-1,4,5-trisphosphate 5-phosphatase activity

INPP5B OCRL

2.46e-048602GO:0052658
GeneOntologyMolecularFunctioninositol tetrakisphosphate phosphatase activity

INPP5B OCRL

3.15e-049602GO:0052743
GeneOntologyMolecularFunctionphosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

INPP5B OCRL

3.93e-0410602GO:0004439
GeneOntologyMolecularFunctionphosphatidylinositol-4,5-bisphosphate phosphatase activity

INPP5B OCRL

5.75e-0412602GO:0106019
GeneOntologyMolecularFunctionphosphatidylinositol phosphate 5-phosphatase activity

INPP5B OCRL

6.78e-0413602GO:0034595
GeneOntologyMolecularFunctionpolyubiquitin modification-dependent protein binding

UBQLN3 DZIP3 MINDY1

7.44e-0459603GO:0031593
GeneOntologyMolecularFunctioninositol trisphosphate phosphatase activity

INPP5B OCRL

7.89e-0414602GO:0046030
GeneOntologyMolecularFunctioninositol phosphate phosphatase activity

INPP5B OCRL

1.63e-0320602GO:0052745
DomainRho_GTPase_activation_prot

INPP5B OCRL SYDE1 PLXNB1

1.72e-0488594IPR008936
DomainIPPc

INPP5B OCRL

4.34e-0410592IPR000300
DomainIPPc

INPP5B OCRL

4.34e-0410592SM00128
DomainAGC-kinase_C

RPS6KA4 GRK4 CDC42BPB

7.37e-0456593IPR000961
DomainAGC_KINASE_CTER

RPS6KA4 GRK4 CDC42BPB

7.37e-0456593PS51285
DomainS_TK_X

RPS6KA4 GRK4 CDC42BPB

7.37e-0456593SM00133
DomainRhoGAP

INPP5B OCRL SYDE1

9.92e-0462593SM00324
DomaintRNAsynth_Ia_anticodon-bd

CEP131 VARS1

1.00e-0315592IPR009080
DomainRhoGAP

INPP5B OCRL SYDE1

1.04e-0363593PF00620
DomainRHOGAP

INPP5B OCRL SYDE1

1.09e-0364593PS50238
DomainRhoGAP_dom

INPP5B OCRL SYDE1

1.09e-0364593IPR000198
Domain-

INPP5B OCRL SYDE1

1.09e-03645931.10.555.10
Domain-

INPP5B OCRL

3.04e-03265923.60.10.10
DomainExo_endo_phos

INPP5B OCRL

3.04e-0326592PF03372
DomainIPT

NFKB2 PLXNB1

3.27e-0327592SM00429
DomainEndo/exonuclease/phosphatase

INPP5B OCRL

3.27e-0327592IPR005135
DomainIPT

NFKB2 PLXNB1

4.58e-0332592IPR002909
DomainPkinase_C

RPS6KA4 CDC42BPB

6.09e-0337592IPR017892
DomainKinase-like_dom

RPS6KA4 GRK4 GUCY2D TRRAP CDC42BPB DYRK3

7.12e-03542596IPR011009
DomainPkinase_C

RPS6KA4 CDC42BPB

7.79e-0342592PF00433
DomainBTB-kelch_protein

KBTBD12 KLHL33

8.15e-0343592IPR017096
Pubmed

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.

EFHC2 GPR83 FAT2 SALL3 KIAA1755 KBTBD12 CFP KLHL33 MSLN DYRK3

3.03e-07674621037196079
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

USP34 CAD NFKB2 NAV1 CEP131 ZDBF2 UBN2 NCKAP5L GARRE1

9.71e-0758862938580884
Pubmed

Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.

UBN2 TRRAP CDC42BPB

1.94e-061462328263302
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

USP34 PHC3 SALL3 PPRC1 INPP5B DZIP3 UBN2 MINDY1 PLXNB1 STAT1 KPNA3

3.04e-061084621111544199
Pubmed

Functional overlap between murine Inpp5b and Ocrl1 may explain why deficiency of the murine ortholog for OCRL1 does not cause Lowe syndrome in mice.

INPP5B OCRL

3.13e-0626229593760
Pubmed

X-inactivation analysis of embryonic lethality in Ocrl wt/-; Inpp5b-/- mice.

INPP5B OCRL

3.13e-06262220195868
Pubmed

Lowe syndrome patient fibroblasts display Ocrl1-specific cell migration defects that cannot be rescued by the homologous Inpp5b phosphatase.

INPP5B OCRL

3.13e-06262219700499
Pubmed

OCRL-mutated fibroblasts from patients with Dent-2 disease exhibit INPP5B-independent phenotypic variability relatively to Lowe syndrome cells.

INPP5B OCRL

3.13e-06262225305077
Pubmed

Disrupted sperm function and fertilin beta processing in mice deficient in the inositol polyphosphate 5-phosphatase Inpp5b.

INPP5B OCRL

3.13e-06262211784089
Pubmed

Kidney Tubular Ablation of Ocrl/Inpp5b Phenocopies Lowe Syndrome Tubulopathy.

INPP5B OCRL

3.13e-06262227895154
Pubmed

Hypoxic repression of STAT1 and its downstream genes by a pVHL/HIF-1 target DEC1/STRA13.

BHLHE40 STAT1

3.13e-06262216878149
Pubmed

Mouse model for Lowe syndrome/Dent Disease 2 renal tubulopathy.

INPP5B OCRL

3.13e-06262221183592
Pubmed

Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.

INPP5B OCRL

9.37e-06362224704254
Pubmed

A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism.

INPP5B OCRL

9.37e-06362219536138
Pubmed

OCRL deficiency impairs endolysosomal function in a humanized mouse model for Lowe syndrome and Dent disease.

INPP5B OCRL

9.37e-06362230590522
Pubmed

OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring.

INPP5B OCRL

9.37e-06362233987909
Pubmed

Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice.

PPRC1 NFKB2

9.37e-06362226942574
Pubmed

RUNX1-IT1 acts as a scaffold of STAT1 and NuRD complex to promote ROS-mediated NF-κB activation and ovarian cancer progression.

NFKB2 STAT1

1.87e-05462238092960
Pubmed

An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.

CAD SALL3 UBN2 KPNA3

2.18e-059162420362542
Pubmed

The CARM1-p300-c-Myc-Max (CPCM) transcriptional complex regulates the expression of CUL4A/4B and affects the stability of CRL4 E3 ligases in colorectal cancer.

USP34 TRRAP MEF2C

2.83e-053362332140074
Pubmed

The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway.

INPP5B OCRL

3.12e-05562221233288
Pubmed

Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.

INPP5B OCRL

3.12e-05562225869668
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

USP34 FKBP15 NAV1 CEP131 ZDBF2 NCKAP5L VARS1 YIPF3

4.64e-0573362834672954
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

EFHC2 FKBP15 DZIP3 NAV1 CEP131 OCRL VPS51 NCKAP5L SYDE1 KPNA3

1.08e-041321621027173435
Pubmed

HIV-1 Tat co-operates with IFN-gamma and TNF-alpha to increase CXCL10 in human astrocytes.

NFKB2 STAT1

1.39e-041062219479051
Pubmed

Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.

USP34 FKBP15 VPS51 MINDY1

1.41e-0414762429576527
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

USP34 PPRC1 NFKB2 NAV1 CEP131 SNAPC4 TRRAP CDC42BPB C8orf58

1.43e-04110562935748872
Pubmed

A human MAP kinase interactome.

NAV1 NCKAP5L BHLHE40 CDC42BPB MEF2C STAT1

2.29e-0448662620936779
Pubmed

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Membrane (M) and Spike (S) Proteins Antagonize Host Type I Interferon Response.

STAT1 KPNA3

2.41e-041362234950606
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

NFKB2 NAV1 OCRL VPS51 TRRAP CDC42BPB YIPF3

2.88e-0471962735337019
Pubmed

Heat-shock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral preintegration complex.

STAT1 KPNA3

3.23e-041562210964507
Pubmed

Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3η as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability.

TRRAP CDC42BPB VARS1 STAT1

7.09e-0422562431478661
Pubmed

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

NFKB2 NAV1 BHLHE40 GARRE1

7.95e-0423262425515538
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

FKBP15 PPRC1 DZIP3 NAV1 PDZD2

8.02e-0440762512693553
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

FAT2 SDK2 CAD VARS1

8.21e-0423462436243803
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

USP34 PHC3 NAV1 CEP131 ZDBF2

9.03e-0441862534709266
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

FKBP15 CAD NAV1 CEP131 ZDBF2 VPS51 CDC42BPB VARS1

9.11e-04113962836417873
Pubmed

Human transcription factor protein interaction networks.

PHC3 CAD NFKB2 CEP131 UBN2 TRRAP GARRE1 MEF2C STAT1

9.27e-04142962935140242
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

NFKB2 HLF IRX6 SNAPC4 BHLHE40 MEF2C STAT1

9.33e-0487762720211142
Pubmed

Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.

RPS6KA4 TIMMDC1

9.89e-042662221399635
Pubmed

Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.

PPRC1 NFKB2 MEF2C STAT1

1.05e-0325062418660489
Pubmed

A census of human transcription factors: function, expression and evolution.

NFKB2 HLF IRX6 SNAPC4 BHLHE40 MEF2C STAT1

1.14e-0390862719274049
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

FKBP15 NAV1 CEP131 NCKAP5L GARRE1

1.20e-0344662524255178
Pubmed

Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism.

PPRC1 MEF2C

1.23e-032962223565059
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

PHC3 CAD CEP131 UBN2 TRRAP CDC42BPB VARS1 STAT1 KPNA3

1.28e-03149762931527615
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

FKBP15 CAD DZIP3 NAV1 CEP131 UBN2 CDC42BPB

1.60e-0396362728671696
Pubmed

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.

TXLNB DZIP3 STAT1 YIPF3

1.65e-0328362421903422
InteractionLURAP1 interactions

FKBP15 TXLNB ZDBF2 VPS51 CDC42BPB SYDE1

3.61e-06137616int:LURAP1
InteractionBMAL1 interactions

HLF DZIP3 VPS51 NCKAP5L BHLHE40

2.15e-05111615int:BMAL1
InteractionUSP7 interactions

EFHC2 GPR83 FAT2 SDK2 SALL3 KIAA1755 KBTBD12 CFP ZDBF2 KLHL33 TRRAP VARS1 MSLN DYRK3

2.88e-0513136114int:USP7
InteractionTUFT1 interactions

GUCY2D DZIP3 VPS51 NCKAP5L

3.96e-0563614int:TUFT1
ToppCellfacs-Lung-EPCAM-18m-Epithelial-Basal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT2 SALL3 HLF PLXNB1 MSLN

6.61e-06189625783c1db856f2defe6f3b8748dd0bc29a8102f6d1
ToppCellfacs-Lung-EPCAM-18m-Epithelial-respiratory_basal_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT2 SALL3 HLF PLXNB1 MSLN

6.61e-0618962588b72fafbe58463543e0818f27f3dd9e5b4d34d2
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-respiratory_basal_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FAT2 SALL3 HLF PLXNB1 MSLN

6.78e-0619062547e07ea22733306d8885ee9e5f0b033e2f5e2afb
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_bronchioalveolar_tree|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FAT2 SALL3 HLF PLXNB1 MSLN

6.78e-06190625261b8afddfdcba4f70b50df126cef7ad00a0aae0
ToppCellCOVID-19-Myeloid-DC2|COVID-19 / Condition, Lineage and Cell class

SDK2 NAV1 CFP MEF2C MSLN

6.96e-061916251304ab7b5713f29f3966ffc020ea1b52e8e2f375
ToppCellPBMC-Mild-Myeloid-cDC-cDC|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

RPS6KA4 NAV1 CFP MEF2C MSLN

8.08e-061976259162ede5572326c00ede0769fe7f4e0dd14d2340
ToppCellPBMC-Mild-Myeloid-cDC|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RPS6KA4 NAV1 CFP MEF2C MSLN

8.08e-06197625021c9c48375259b808e1f36a029c4fe6971c00eb
ToppCellPBMC-Mild-Myeloid-cDC|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

RPS6KA4 NAV1 CFP MEF2C MSLN

8.08e-0619762518df0e447bcea2a405a357563f87bacc57466227
ToppCellPBMC-Severe-Myeloid-cDC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RPS6KA4 NAV1 CFP MEF2C MSLN

8.08e-0619762522e4ffb5de483eaf78f14badf3d08db898e3b3dd
ToppCellPBMC-Mild-Myeloid-cDC-cDC|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RPS6KA4 NAV1 CFP MEF2C MSLN

8.08e-061976250460b6907743a354792b5bc40bff01aac7c41684
ToppCellPBMC-Severe-Myeloid-cDC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

RPS6KA4 NAV1 CFP MEF2C MSLN

8.08e-06197625346974c6c5809a3fe88cbf067e2d64c340310a31
ToppCellCOVID-19_Mild-Myeloid-cDC|COVID-19_Mild / Disease group, lineage and cell class

RPS6KA4 NAV1 CFP MEF2C MSLN

8.08e-061976252901904b8a791fac2668fd737eff7e7144378db4
ToppCellPBMC-Severe-Myeloid-cDC-cDC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RPS6KA4 NAV1 CFP MEF2C MSLN

8.08e-061976251ae45c1ec3b3f88e0c1f99de58c58b1ec1b968ee
ToppCellCOVID-19_Severe-Myeloid-cDC|COVID-19_Severe / Disease group, lineage and cell class

RPS6KA4 NAV1 CFP MEF2C MSLN

8.08e-06197625843b0f1cc26864ee635df7938c77552ee06fe00b
ToppCellPBMC-Severe-Myeloid-cDC-cDC|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

RPS6KA4 NAV1 CFP MEF2C MSLN

8.08e-06197625f78f44dcd7855c96f148678c1f416075aef71b4e
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4|GI_small-bowel / Manually curated celltypes from each tissue

NFKB2 HLF GPSM3 BHLHE40 PDZD2

8.28e-061986256333e46cd1ccf5841ce15aea98a4b2f5e3ae4675
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-Trm_Th1/Th17|GI_small-bowel / Manually curated celltypes from each tissue

NFKB2 HLF GPSM3 BHLHE40 PDZD2

8.49e-06199625508a6efc11b1b45899a968888865731088cac668
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Hpgd|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

OMA1 SDK2 BHLHE40 PDZD2

2.88e-051266249b04ca8a46cc30119baf6ef27711a0b2a6b4a0c9
ToppCellmetastatic_Brain-Myeloid_cells-CD1c+_DCs|Myeloid_cells / Location, Cell class and cell subclass

REC8 EFHC2 INPP5B CFP

4.60e-051426241eecbec805a873fa3539df0574670cf73c18c7b1
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PPRC1 NFKB2 NAV1 CFP

5.55e-05149624a85a051e0d82430160967e72fa04b55f43e84513
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PPRC1 NFKB2 NAV1 CFP

5.70e-051506247a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCellwk_15-18-Epithelial-Proximal_epithelial-basal_intermediate_|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

DUOX1 FAT2 GUCY2D HLF

6.97e-0515862498712ed7e8e65e8c5ff9318cf0e0a04e271a055d
ToppCell10x5'-Liver-Lymphocytic_T_CD4-Tnaive/CM_CD4_activated|Liver / Manually curated celltypes from each tissue

CDC42BPB GARRE1 MINDY1 C8orf58

8.44e-051666249afa33b5ad27dc33576be592f9b22d8161366838
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-plasma_cell-plasma_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM52 TXLNB KBTBD12 DYRK3

8.64e-051676248ec7a98b542b134f48df8fbec351693cc5cfe55c
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-plasma_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM52 TXLNB KBTBD12 DYRK3

8.64e-05167624a9f28c4649ce344ae3ba3a3acb58da9c7efad901
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-B_cells-STAT1+_Naive_B|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPSM3 GARRE1 MEF2C STAT1

8.84e-05168624ba127d97697202a8558a0d50bcdafa30b0509de1
ToppCellfacs-Lung-EPCAM-18m-Lymphocytic-plasma_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM52 TXLNB KBTBD12 DYRK3

9.04e-05169624e348d9877a1bcad4f33dd7b2ce6cb0049583c4d2
ToppCellfacs-Lung-EPCAM-18m-Lymphocytic-Plasma_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM52 TXLNB KBTBD12 DYRK3

9.04e-051696243167ca0c826244280e0e07d1e02656cf5e4e75a5
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPSM3 CFP MEF2C STAT1

9.25e-051706243e52d40b0c36ab5b627a2dad025248901af8a320
ToppCelldroplet-Fat-Gat-18m-Lymphocytic-B_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KBTBD12 VARS1 MEF2C DYRK3

9.25e-051706245185187ecf26b4c9eaa0c01ad52697ab8d075cc7
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-Zbtb32+_B|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UBQLN3 KLHL33 VARS1 MEF2C

1.01e-0417462428ec25767bbd4fd898738f9f4d2b585dc91b5adf
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TXLNB INPP5B NAV1 MEF2C

1.01e-0417462459ccc5a82507463e0a316ba6286cb25ec1a4091b
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT2 RPS6KA4 BHLHE40 PLXNB1

1.01e-04174624207aa0118633cbe9a65839bbb1bb3ba9f8118ad2
ToppCelldroplet-Mammary_Gland-nan-21m-Endothelial-basal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT2 KIAA1755 C8orf58 PDZD2

1.06e-0417662427e5115fae5f0f63b333bc99fbf6a6d4c9182c46
ToppCell3'_v3-lymph-node_spleen-Myeloid_Dendritic-DC2|lymph-node_spleen / Manually curated celltypes from each tissue

RPS6KA4 NAV1 CFP MSLN

1.06e-0417662472a3bbab0540ae3e3c94b9573cdb9298a024dbc4
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-11|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NFKB2 DZIP3 CDC42BPB MEF2C

1.08e-041776243535575686c9700ab72700aae6f2070ebbb50044
ToppCellLV|World / Chamber and Cluster_Paper

TXLNB KBTBD12 MEF2C PDZD2

1.15e-041806245ac6f485a58bb29462fec02dfbe8eb70864eafe3
ToppCellTCGA-Mesothelium-Primary_Tumor-Mesothelioma-Epitheliod|TCGA-Mesothelium / Sample_Type by Project: Shred V9

OMA1 PLXNB1 MSLN PDZD2

1.20e-04182624bb1f815718397de96682697fcbd6014a992a28f7
ToppCell3'-Adult-LargeIntestine-Epithelial-Tuft-related-Microfold_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SDK2 NFKB2 CFP MSLN

1.20e-04182624b4f347fb684f6840c166d7473f3f56389f69c14b
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR83 SDK2 KIAA1755 MEF2C

1.23e-04183624547b1fb9f9940cfc8d6e351d96acc0da44def57e
ToppCell3'_v3-bone_marrow-Myeloid_Dendritic-DC2|bone_marrow / Manually curated celltypes from each tissue

RPS6KA4 CFP MEF2C MSLN

1.23e-04183624f482e4fe011fa450a475034b1e25587233855bdb
ToppCellCOVID-19-kidney-FLT1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

BHLHE40 CDC42BPB GARRE1 MEF2C

1.28e-04185624673308ca0514a4d3629d61fe91e9d8fb31b72166
ToppCell3'-Adult-LargeIntestine-Hematopoietic-Myeloid-Lymphoid_DC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DUOX1 FAT2 GPSM3 CFP

1.34e-04187624d69f4eee0304a7db226275ab77fc9d5d2b6f3a07
ToppCell3'_v3-bone_marrow-Myeloid_Dendritic-pDC|bone_marrow / Manually curated celltypes from each tissue

SDK2 RPS6KA4 KLHL33 MEF2C

1.42e-04190624dde0e34f6a06cdbbb65c86472360c09f0279a572
ToppCellhuman_hepatoblastoma-Endothelial_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

NAV1 MEF2C DYRK3 PDZD2

1.42e-041906248d6ef93d69e96cd6921816d152bea3b0710cf147
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NPAP1 MMP21 IRX6 STAT1

1.42e-04190624078f4be52fa4cc8dd9c8d7a2b6d9631c3d902285
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_6|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NAV1 CFP BHLHE40 MSLN

1.45e-041916246cda82a994f4b205cf54590c979d7c9f3be2b4c8
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_6|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NAV1 CFP BHLHE40 MSLN

1.45e-041916244257f02856f3510981e9f84d465d91448d6126e2
ToppCellILEUM-inflamed-(1)_T_cell-(1)_Th17_Trm|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

NFKB2 GPSM3 BHLHE40 STAT1

1.48e-0419262412f7ea575da5d650c740e6060f5dab0478e563dd
ToppCellILEUM-non-inflamed-(1)_Th17_Trm|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

NFKB2 GPSM3 BHLHE40 STAT1

1.48e-041926247347ff4dedd1aaa489c4f15e5ae647a4ce39ac72
ToppCellhuman_hepatoblastoma-Endothelial_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

NAV1 MEF2C DYRK3 PDZD2

1.48e-04192624e09f609fed033a25baacaf4a07bbbae1076da366
ToppCellCOVID-19-Myeloid-DC2|Myeloid / Condition, Lineage and Cell class

SDK2 NAV1 MEF2C MSLN

1.51e-041936245f3f6db3d3de887d004662d229f42549601efa81
ToppCellMonocytes-HP_01|World / lung cells shred on cell class, cell subclass, sample id

GPSM3 CFP MEF2C STAT1

1.54e-04194624fa6a2794baa6be6298f415330ff51b26a5402571
ToppCellBAL-Mild-Myeloid-cDC|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

NFKB2 NAV1 CFP MEF2C

1.57e-041956246ba23e19801305e071b0e4aaf1ee6f53f3b027d3
ToppCellBAL-Mild-Myeloid-cDC-cDC|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NFKB2 NAV1 CFP MEF2C

1.57e-0419562466e5fd9f3208a06d617c5e994822bf57dceae7e2
ToppCellBAL-Mild-Myeloid-cDC-cDC|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

NFKB2 NAV1 CFP MEF2C

1.57e-041956247209babdff96c93cd52cfe5d5cfd7e3c0274d8dd
ToppCell(010)_cDC|World / immune cells in Peripheral Blood (logTPM normalization)

NAV1 CFP MEF2C MSLN

1.57e-041956244aabb3f5ce70100e4d98d7fa9f8d12e84fb9fe3d
ToppCellBAL-Mild-Myeloid-cDC|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NFKB2 NAV1 CFP MEF2C

1.57e-041956249e5cf33b5dd455efa464a63d7116786c0786aefd
ToppCellMild_COVID-19-Myeloid-cDC|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

NFKB2 NAV1 CFP MEF2C

1.57e-0419562424149bb6933135b1a0a5c7f505914942b3782c3a
ToppCellCOVID-19_Moderate-cDC|World / disease group, cell group and cell class

RPS6KA4 CFP BHLHE40 MEF2C

1.60e-0419662492a236adf386f05d020b1954bbdc5bd32346cbf0
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NAV1 CFP MEF2C MSLN

1.60e-041966240bac14c018487ca67e7f9255b5f186e7ae665774
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NAV1 CFP MEF2C MSLN

1.60e-0419662433345338c825484960daa1ed82a19df38ccfc5c0
ToppCellHealthy_donor-cDC|Healthy_donor / disease group, cell group and cell class (v2)

RPS6KA4 NAV1 CFP MSLN

1.63e-04197624b57a27e5b855bbdd1dfa352540599d260dc482aa
ToppCelldistal-Endothelial-Bronchial_Vessel_2-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HLF TIMMDC1 BHLHE40 MEF2C

1.63e-041976249fcfbfbe78e8fe90c76eb37a58ed9dc8ece652a1
ToppCellHealthy/Control-cDC|Healthy/Control / Disease group and Cell class

RPS6KA4 NAV1 CFP MSLN

1.63e-04197624926423aae9fcf654f84b0f7621103a6a22d3aced
ToppCellHealthy_donor-cDC|World / disease group, cell group and cell class (v2)

RPS6KA4 NAV1 CFP MSLN

1.63e-04197624a545fe3a80cd721bf01115bbb645753840ec9f40
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RPS6KA4 CFP MEF2C MSLN

1.66e-04198624d0371e2ca9e25727b35985940f6228f9d8e49727
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RPS6KA4 CFP MEF2C MSLN

1.66e-0419862408ad0bece508bb4f9cc126d94839b5c89ce21ba8
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)

REC8 NFKB2 BHLHE40 STAT1

1.66e-0419862444417089b62056269cac38d3134ff209c05b7007
ToppCellHealthy-cDC|Healthy / disease group, cell group and cell class

NAV1 CFP BHLHE40 MEF2C

1.66e-041986244cf874333b9fd6cd22ee647cd12c032fc6d05740
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

REC8 NFKB2 BHLHE40 STAT1

1.66e-0419862428ef3fc4c17dcb765537b75917f7db78baa522db
ToppCellMS-Multiple_Sclerosis-Myeloid-pDC|Multiple_Sclerosis / Disease, condition lineage and cell class

RPS6KA4 GUCY2D KLHL33 MEF2C

1.69e-04199624c10c8c9322cad4996e4aa11a8680e3d781644ace
ToppCellcontrol-cDC|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

RPS6KA4 NAV1 CFP MEF2C

1.69e-0419962431825ba336603fe940dea6022e18ec25af110f4c
ToppCellBiopsy_IPF-Epithelial-AT2|Biopsy_IPF / Sample group, Lineage and Cell type

DUOX1 HLF IRX6 PDZD2

1.69e-04199624c841d475703d3489161fb7904526bd7563d5fb0f
ToppCellcontrol|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DUOX1 FAT2 HLF PLXNB1

1.73e-0420062497f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCellCOVID-19-COVID-19_Severe-Myeloid-cDC|COVID-19_Severe / Disease, condition lineage and cell class

RPS6KA4 NAV1 CFP MEF2C

1.73e-04200624e7b808d8ed65343a4345fafb03015fe4f7ce302f
ToppCellCOVID-19-COVID-19_Mild-Myeloid-cDC|COVID-19_Mild / Disease, condition lineage and cell class

RPS6KA4 NAV1 CFP MEF2C

1.73e-04200624b8f52e65813d331c49cdd5f354fdfec6fc8c339e
ToppCellNS-control|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DUOX1 FAT2 HLF PLXNB1

1.73e-04200624ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCellsevere-cDC|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

RPS6KA4 NAV1 CFP MEF2C

1.73e-0420062426e04ea276dbca5cde48335c401269c7123b54d2
ToppCellmild-cDC|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

RPS6KA4 NAV1 CFP MEF2C

1.73e-04200624d6409ee5b9067be3dd2f852825e09151b5b22d7c
DrugDantrolene sodium salt [14663-23-1]; Down 200; 11.8uM; PC3; HT_HG-U133A

INPP5B NFKB2 HLF MEF2C SYDE1 STAT1

1.29e-051936164343_DN
DrugGallamine triethiodide [65-29-2]; Up 200; 4.4uM; PC3; HT_HG-U133A

FKBP15 NFKB2 CEP131 SNAPC4 SYDE1 MINDY1

1.45e-051976162059_UP
DrugAH23848 hemicalcium salt hydrate; Down 200; 1uM; MCF7; HT_HG-U133A

USP34 PHC3 CAD INPP5B TRRAP PLXNB1

1.45e-051976166903_DN
DrugPHA-00767505E [723337-45-9]; Down 200; 10uM; MCF7; HT_HG-U133A

USP34 INPP5B NFKB2 DZIP3 OCRL TRRAP

1.45e-051976166550_DN
DrugNoscapine [128-62-1]; Down 200; 9.6uM; MCF7; HT_HG-U133A

USP34 DZIP3 CEP131 SNAPC4 SYDE1 STAT1

1.50e-051986167204_DN
DrugFipexide hydrochloride [34161-23-4]; Up 200; 9.4uM; PC3; HT_HG-U133A

EFHC2 GRK4 HLF SNAPC4 MEF2C SYDE1

1.58e-052006165737_UP
Diseaseuric acid measurement

USP34 RPS6KA4 DAZAP1 GUCY2D HLF NAV1 VPS51

2.33e-04610607EFO_0004761
DiseaseInfiltrating duct carcinoma of female breast

RPS6KA4 CDC42BPB

8.33e-0421602C3165106
DiseaseNeurodevelopmental Disorders

CDC42BPB MEF2C PLXNB1

9.11e-0493603C1535926
DiseaseLarge cell carcinoma of lung

TRRAP CDC42BPB

1.94e-0332602C0345958
DiseaseBurkitt Lymphoma

SALL3 HLF

2.45e-0336602C0006413
Diseasesystemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, rheumatoid factor negative, oligoarticular juvenile idiopathic arthritis

TIMMDC1 STAT1

3.02e-0340602EFO_1001999, EFO_1002019, EFO_1002020
Diseasebiliary liver cirrhosis

RPS6KA4 TIMMDC1

3.64e-0344602EFO_0004267

Protein segments in the cluster

PeptideGeneStartEntry
MERIPSAQPPPACLP

BHLHE40

1

O14503
PERPQCRPHRKTFMP

C8orf58

336

Q8NAV2
DPKPCTPRGMQPERT

DAZAP1

81

Q96EP5
ECPMVQPPERTIRGP

REC8

331

O95072
PECRMIPGQPPASAR

IRX6

376

P78412
LTPQRLQCPMDTDPP

DUOX1

981

Q9NRD9
LQCPMDTDPPQEIRR

DUOX1

986

Q9NRD9
NLCRNKDPPPPMETV

KPNA3

226

O00505
PRPRAEMPACILTLP

KLHL33

501

A6NCF5
CQRMEAQRSEPPLPP

GPSM3

116

Q9Y4H4
CPPRQLEGLPRTPMA

NCKAP5L

1251

Q9HCH0
RSPPPLCRPLVSMDQ

GUCY2D

761

Q02846
RNGRLPKPMPCPSRN

KIAA1755

446

Q5JYT7
NPPVQCPEDPYMKIR

EFHC2

186

Q5JST6
SRDCLPPVMPDECPQ

PLXNB1

76

O43157
QNLEDLMPSRPPSPR

FAT2

4246

Q9NYQ8
AMNRPRCGVPDMRPP

MMP21

111

Q8N119
KGMDQPRPSARQEPP

PDZD2

2706

O15018
LDPQHPVMPRKVCPN

PGLYRP3

166

Q96LB9
PLNRERPESPMVPSE

FKBP15

971

Q5T1M5
MPQELPQSPRTRQPE

MINDY1

96

Q8N5J2
QRLCAVPPPNFEMPV

MEF2C

131

Q06413
EMSPQAPRRPLPQVA

MSLN

406

Q13421
RLRPQSPGVPMQTPC

RPS6KA4

556

O75676
CMPPCGPNPTRARQR

CFP

391

P27918
PNCMQSPIRPGQLLP

HLF

141

Q16534
EDMARPPQRPSAVPL

CDC42BPB

996

Q9Y5S2
SMCQRPPKPQEDRPP

GPR83

361

Q9NYM4
DECVRMDRTPPPPTL

PHC3

601

Q8NDX5
FRPILTVPQMPAVCP

DZIP3

976

Q86Y13
GRRQTPPQPMQCELP

GARRE1

326

O15063
RMQFCQPDPSLPPLT

INPP5B

501

P32019
PPAHKLEMPRQPDCQ

ERCC6L2

731

Q5T890
RLEANMLEPPFCPDP

GRK4

456

P32298
KRDRPQPPSRPMVQQ

SDK2

1396

Q58EX2
MLAPPPRRTPKQHNC

SALL3

1101

Q9BXA9
PPENPRETRVPGMRQ

CEP131

361

Q9UPN4
SPCRNDMNTRTPPEP

PPRC1

1381

Q5VV67
CNPSEPPPPRRLNMT

DYRK3

51

O43781
VARMNPRDLIPPPSD

KBTBD12

601

Q3ZCT8
RVLDAEPPEMPPCRR

NAV1

1496

Q8NEY1
EPPEMPPCRRGVNNI

NAV1

1501

Q8NEY1
LEAMARDPPNRVPPT

SYDE1

496

Q6ZW31
PRRMPQAPPSLCVTP

VARS1

1076

P26640
RQPCMPTHPQRPLVL

STAT1

321

P42224
PPNYCSQRPRLQRMP

ST6GALNAC6

266

Q969X2
PVQDCPRMRGQQPLT

PRAMEF27

136

A3QJZ7
TMIPVRPCARLAPNP

ABCC12

31

Q96J65
RMPDEKPFCIPPRSA

NPAP1

301

Q9NZP6
EMCNCPPLSNPDPRL

OMA1

461

Q96E52
PPPNLMARQTPSDRQ

OCRL

871

Q01968
ALRCPDPVPMEPSVV

VPS51

761

Q9UID3
PLPQREVSRAEPPMS

UBN2

71

Q6ZU65
LPPARQPCDVAVIPM

TMEM52

91

Q8NDY8
RGMPLECPPRPERLN

SMRP1

141

Q8NCR6
MEVPPPAPRSFLCRA

TIMMDC1

1

Q9NPL8
MANPPPKRPVRASCR

ZDBF2

2286

Q9HCK1
CAMPNTRPPIIDAPA

CAD

1501

P27708
NIPPIQRVPRDIPAM

YIPF3

311

Q9GZM5
PPANMNREPEPSCRT

SNAPC4

1136

Q5SXM2
VAAMVPACEPSRQPP

TXLNB

641

Q8N3L3
SNIRPPRPELNMCLL

USP34

3106

Q70CQ2
VEAMSQCVPPIPIRP

TRRAP

2676

Q9Y4A5
SQPSRMENCDPLPNP

UBQLN3

291

Q9H347
PSRTPQCEPQAPEML

NFKB2

426

Q00653