Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvitamin transmembrane transporter activity

SLC19A2 SLC19A3 SLC2A6 SLC52A2

8.34e-05361294GO:0090482
PathwayKEGG_ANTIGEN_PROCESSING_AND_PRESENTATION

KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

4.89e-05881056M16004
PathwayKEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY

KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5 NFAT5

7.24e-051371057M5669
Pubmed

NullHap--a versatile application to estimate haplotype frequencies from unphased genotypes in the presence of null alleles.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

7.70e-178132718681957
Pubmed

Assessment of killer cell immunoglobulinlike receptor expression and corresponding HLA class I phenotypes demonstrates heterogenous KIR expression independent of anticipated HLA class I ligands.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.15e-1510132712559621
Pubmed

[Genotype analysis of killer cell immunoglobulin-like receptors in Graves' disease patients].

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

3.15e-1511132719664392
Pubmed

Association of killer cell immunoglobulin-like receptor 2DL5 with systemic lupus erythematosus and accompanying infections.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

7.53e-1512132720371502
Pubmed

Distribution of killer cell immunoglobulin-like receptors (KIR) and their HLA-C ligands in two Iranian populations.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

7.53e-1512132719936734
Pubmed

Association of killer cell immunoglobulin-like receptors with primary Sjogren's syndrome.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

7.53e-1512132719181658
Pubmed

KIR and HLA genotypes are associated with disease progression and survival following autologous hematopoietic stem cell transplantation for high-risk neuroblastoma.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.63e-1413132719934297
Pubmed

Different KIRs confer susceptibility and protection to adults with latent autoimmune diabetes in Latvian and Asian Indian populations.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.63e-1413132719120281
Pubmed

[Study on the polymorphism of killer cell immunoglobulin like receptor (KIR) gene with systemic lupus erythematosus of North population in China].

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.63e-1413132718687225
Pubmed

Frequencies of killer immunoglobulin-like receptor genotypes influence susceptibility to spontaneous abortion.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

3.24e-1414132719875891
Pubmed

Multiple sclerosis associates with LILRA3 deletion in Spanish patients.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

3.24e-1414132719421224
Pubmed

Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

3.24e-1414132715896204
Pubmed

Killer cell immunoglobulin-like receptor gene diversity in a Caucasian population of southern Brazil.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

6.06e-1415132720082646
Pubmed

Killer cell immunoglobulin-like receptors in HLA-B27-associated acute anterior uveitis, with and without axial spondyloarthropathy.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

6.06e-1415132719850842
Pubmed

[Killer cell immunoglobin-like receptor and its ligand gene polymorphisms in Hunan Han patients with type 1 diabetes].

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

6.06e-1415132720356536
Pubmed

Disparate distribution of activating and inhibitory killer cell immunoglobulin-like receptor genes in patients with systemic lupus erythematosus.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

6.06e-1415132719926642
Pubmed

Natural killer-cell receptor polymorphisms and posttransplantation non-Hodgkin lymphoma.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

6.06e-1415132720207982
Pubmed

Killer immunoglobulin-like receptors (KIR2DL2 and/or KIR2DS2) in presence of their ligand (HLA-C1 group) protect against chronic myeloid leukaemia.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

6.06e-1415132719493232
Pubmed

Inhibitory KIR and specific HLA-C gene combinations confer susceptibility to or protection against chronic hepatitis B.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

6.06e-1415132720643584
Pubmed

KIR genes polymorphism in Argentinean Caucasoid and Amerindian populations.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

6.06e-1415132717498266
Pubmed

Killer cell immunoglobulin-like receptor genotype and killer cell immunoglobulin-like receptor-human leukocyte antigen C ligand compatibility affect the severity of hepatitis C virus recurrence after liver transplantation.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

6.06e-1415132719326408
Pubmed

Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada syndrome in Japanese individuals.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.07e-1316132719897003
Pubmed

Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Java, Kalimantan, Timor and Irian Jaya.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.07e-1316132719000141
Pubmed

Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Sumatra, Sulawesi and Moluccas Islands.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.07e-1316132720670355
Pubmed

Asian population frequencies and haplotype distribution of killer cell immunoglobulin-like receptor (KIR) genes among Chinese, Malay, and Indian in Singapore.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.07e-1316132718668235
Pubmed

Distribution of killer cell immunoglobulin-like receptor (KIR) genotypes in patients with familial Mediterranean fever.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.07e-1316132719309280
Pubmed

[Polymorphism of killer cell immunoglobulin-like receptors gene family in Zhejiang Han population].

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.07e-1316132716403292
Pubmed

Activating killer cell immunoglobulin-like receptor genes' association with recurrent miscarriage.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.07e-1316132719527230
Pubmed

Polymorphisms of KIR gene and HLA-C alleles: possible association with susceptibility to HLA-B27-positive patients with ankylosing spondylitis.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.07e-1316132720652381
Pubmed

Influence of activating and inhibitory killer immunoglobulin-like receptors on predisposition to recurrent miscarriages.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.07e-1316132719279038
Pubmed

No association of KIR genes with Behcet's disease.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.07e-1316132717868255
Pubmed

A study of the killer cell immunoglobulin-like receptor gene KIR2DS1 in a Caucasoid Brazilian population with psoriasis vulgaris.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.07e-1316132718643961
Pubmed

Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.07e-1316132720331834
Pubmed

HLA-DQA1*0505 sharing and killer immunoglobulin-like receptors in sub fertile couples: report from the 15th International Histocompatibility Workshop.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.07e-1316132720210919
Pubmed

[Effects of killer immunoglobulin-like receptor and human leukocyte antigen class I ligand on the prognosis of related donor hematopoietic stem cell transplantation].

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.82e-1317132719968064
Pubmed

Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.82e-1317132720878400
Pubmed

Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.82e-1317132720650299
Pubmed

The beneficial impact of missing KIR ligands and absence of donor KIR2DS3 gene on outcome following unrelated hematopoietic SCT for myeloid leukemia in the Chinese population.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.82e-1317132720173784
Pubmed

The role of killer immunoglobulin-like receptor haplotypes on the outcome of unrelated donor haematopoietic SCT for thalassaemia.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.82e-1317132720173792
Pubmed

Role of killer cell immunoglobulin-like receptor gene content and human leukocyte antigen-C group in susceptibility to human T-lymphotropic virus 1-associated myelopathy/tropical spastic paraparesis in Peru.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.82e-1317132720483367
Pubmed

[Analysis of natural killer cell immunoglobulin-like receptor genes in Chinese].

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.82e-1317132719218127
Pubmed

KIR genes and KIR ligands affect occurrence of acute GVHD after unrelated, 12/12 HLA matched, hematopoietic stem cell transplantation.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.82e-1317132719169284
Pubmed

Killer cell immunoglobulin-like receptor gene polymorphisms in patients with leukemia: possible association with susceptibility to the disease.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.82e-1317132719450876
Pubmed

Distribution of killer-cell immunoglobulin-like receptor genes in Eastern mainland Chinese Han and Taiwanese Han populations.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.82e-1317132719761533
Pubmed

Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS3 KIR2DS5

2.22e-13913267749980
Pubmed

Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

2.97e-1318132719630074
Pubmed

Signatures of natural selection and coevolution between killer cell immunoglobulin-like receptors (KIR) and HLA class I genes.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

2.97e-1318132720200544
Pubmed

Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

2.97e-1318132719046302
Pubmed

Association of killer cell immunoglobulin-like receptors and human leukocyte antigen-C genotypes in South Brazilian with type 1 diabetes.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

2.97e-1318132720580654
Pubmed

Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

2.97e-1318132720519398
Pubmed

Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

2.97e-1318132719846535
Pubmed

KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

4.69e-1319132718571006
Pubmed

Association between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

4.69e-1319132718778326
Pubmed

Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with solid tumors.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

4.69e-1319132720600442
Pubmed

Killer cell immunoglobulin-like receptor gene diversity in a Southern Brazilian population from the state of ParanĂ¡.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

4.69e-1319132718848853
Pubmed

Compound KIR-HLA genotype analyses in the Iranian population by a novel PCR-SSP assay.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

7.19e-1320132720193031
Pubmed

Association of killer cell immunoglobulin-like receptor genotypes with vascular arterial events and anticardiolipin antibodies in patients with lupus.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1

7.30e-135132518755860
Pubmed

Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1

7.30e-135132516112031
Pubmed

Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.07e-1221132719861144
Pubmed

Natural killer cells and immune surveillance.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS3 KIR2DS5

1.21e-1211132618830515
Pubmed

Distribution of KIR genes in the population of unrelated individuals homozygous for ancestral haplotype AH8.1 (HLA-A1B8DR3).

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.57e-1222132720492596
Pubmed

[Relationship between CMV reactivation and KIR haplotype/HLA-Cw genotype in patients after unrelated-donor hematopoietic stem cell transplantation.].

KIR2DS2 KIR2DL1 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

2.42e-1212132620137308
Pubmed

Associations of killer cell immunoglobulin-like receptor genes with complications of rheumatoid arthritis.

KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3

4.36e-126132517882223
Pubmed

[Genotype and haplotype analysis of killer cell immunoglobulin-like receptors in ankylosing spondylitis].

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3

7.81e-1214132619489269
Pubmed

Immunogenetic characteristics of patients with autoimmune gastritis.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.41e-1129132720082482
Pubmed

Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1

1.52e-117132511169255
Pubmed

Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation.

KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

3.19e-1117132619032228
Pubmed

Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS3 KIR2DS5

4.77e-1118132620210918
Pubmed

Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

5.95e-1135132719683555
Pubmed

Alternatively spliced forms of human killer inhibitory receptors.

KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS3 KIR2DS5

9.08e-11913258662091
Pubmed

HLA and KIR frequencies in Sicilian Centenarians.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS1 KIR2DS3 KIR2DS5

9.89e-1120132620426625
Pubmed

Investigation of activating and inhibitory killer cell immunoglobulin-like receptors and their putative ligands in type 1 diabetes (T1D).

KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1

1.98e-104132426542066
Pubmed

Diversity of the repertoire of p58 killer cell inhibitory receptors in a single individual.

KIR2DS2 KIR2DL1 KIR2DL3 KIR2DS1

9.88e-105132410424431
Pubmed

In contrast to other stimulatory natural killer cell immunoglobulin-like receptor loci, several KIR2DS5 alleles predominate in African Americans.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS5

9.88e-105132419410616
Pubmed

Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS1 KIR2DS5

1.42e-0914132518945962
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

SEC16B RAPGEF6 EP400 ESRRA ITSN1 CAMSAP3 ADARB1 EFTUD2 SETD2 SVIL DMWD OGA AKAP1 BAG6 CSTF2T WDR62 SON

6.72e-097741321715302935
Pubmed

Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS5

6.88e-097132414607943
Pubmed

Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors.

KIR2DL1 KIR2DL3 KIR2DS1 KIR2DS3

6.88e-09713249430220
Pubmed

Human diversity in killer cell inhibitory receptor genes.

KIR2DL1 KIR2DL3 KIR2DS1 KIR2DS3

1.37e-08813249430221
Pubmed

Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals.

KIR2DS2 KIR2DL1 KIR2DS1 KIR2DS3

2.46e-089132418340360
Pubmed

Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus.

KIR2DL2 KIR2DS1 KIR2DS3 KIR2DS5

4.09e-0810132421206914
Pubmed

Prognostic role of KIR genes and HLA-C after hematopoietic stem cell transplantation in a patient cohort with acute myeloid leukemia from a consanguineous community.

KIR2DS2 KIR2DL1 KIR2DS1

5.34e-083132329549293
Pubmed

Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients.

KIR2DS2 KIR2DL2 KIR2DL3

5.34e-083132330696053
Pubmed

Activating killer immunoglobulin-like receptor incompatibilities enhance graft-versus-host disease and affect survival after allogeneic hematopoietic stem cell transplantation.

KIR2DS1 KIR2DS3 KIR2DS5

5.34e-083132319500138
Pubmed

Associations of killer cell immunoglobulin- like receptor genes with rheumatoid arthritis.

KIR2DS2 KIR2DL2 KIR2DL3

5.34e-083132322960345
Pubmed

[Effect of demethylation treatment on the expression of inhibitory receptor KIR gene in NK-92MI cell line].

KIR2DL1 KIR2DL2 KIR2DL3

5.34e-083132319549382
Pubmed

Lack of killer immunoglobulin-like receptor 2DS2 (KIR2DS2) and KIR2DL2 is associated with poor responses to therapy of recurrent hepatitis C virus in liver transplant recipients.

KIR2DS2 KIR2DL2 KIR2DS1

5.34e-083132319877200
Pubmed

Comparison of killer Ig-like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donors.

KIR2DL1 KIR2DL2 KIR2DL3

5.34e-083132315879158
Pubmed

Homozygosity for killer immunoglobin-like receptor haplotype A predicts complete molecular response to treatment with tyrosine kinase inhibitors in chronic myeloid leukemia patients.

KIR2DS2 KIR2DL2 KIR2DS1

5.34e-083132323380384
Pubmed

Imputation of KIR Types from SNP Variation Data.

KIR2DS2 KIR2DL2 KIR2DL3

5.34e-083132326430804
Pubmed

Cutting edge: selective expression of inhibitory or activating killer cell Ig-like receptors in circulating CD4+ T lymphocytes.

KIR2DS2 KIR2DL2 KIR2DL3

5.34e-083132318292496
Pubmed

[Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia].

KIR2DS2 KIR2DL1 KIR2DL3 KIR2DS5

9.58e-0812132417490516
Pubmed

B-lymphoma cells escape rituximab-triggered elimination by NK cells through increased HLA class I expression.

KIR2DL1 KIR2DL2 KIR2DL3

2.13e-074132320056126
Pubmed

KIR/HLA ligand incompatibility in kidney transplantation.

KIR2DS2 KIR2DL2 KIR2DL3

2.13e-074132318091530
Pubmed

Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general.

KIR2DL1 KIR2DL2 KIR2DL3

2.13e-074132325037176
Pubmed

HLA-C and KIR genes in hepatitis C virus infection.

KIR2DL1 KIR2DL2 KIR2DL3

2.13e-074132316571411
Pubmed

Killer Ig-like receptor (KIR) genotype and HLA ligand combinations in ulcerative colitis susceptibility.

KIR2DS2 KIR2DL2 KIR2DL3

2.13e-074132316929347
Pubmed

[Analysis of HLA-Cw, KIR2D genetic variations in 2 Chinese populations].

KIR2DL1 KIR2DL2 KIR2DL3

2.13e-074132318543232
Pubmed

[Distribution of immunoglobulin like receptor gene in Han population in China and the impact thereof on the HLA-identical sibling hematopoietic stem cell transplantation].

KIR2DL1 KIR2DL2 KIR2DL3

2.13e-074132318269867
Pubmed

A role for KIR gene variants other than KIR2DS1 in conferring susceptibility to psoriasis.

KIR2DS1 KIR2DS3 KIR2DS5

2.13e-074132316829306
InteractionKIR2DS3 interactions

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS5 D2HGDH

2.31e-09201306int:KIR2DS3
InteractionKIR3DP1 interactions

KIR2DS2 KIR2DL1 KIR2DS5

1.04e-0641303int:KIR3DP1
InteractionKIR2DL2 interactions

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3

1.13e-06131304int:KIR2DL2
InteractionKIR2DS2 interactions

KIR2DS2 KIR2DL2 KIR2DS1 KIR2DS3 KIR2DS5

3.82e-06371305int:KIR2DS2
InteractionC2CD4B interactions

APC LRP1B PHKB SETD2 SVIL

9.18e-06441305int:C2CD4B
Cytoband19q13.4

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

3.38e-0979132719q13.4
GeneFamilyCD molecules|Killer cell immunoglobulin like receptors

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

1.68e-1218897620
GeneFamilyVestigial like family

VGLL4 VGLL1

1.43e-044892367
GeneFamilyLEM domain containing

LEMD3 LEMD1

4.95e-0478921087
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ANPEP NT5E KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS5

7.19e-04394898471
GeneFamilyCopines

CPNE3 CPNE4

8.43e-049892829
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

MAP1B CAMSAP3 APC WNK1 AKAP1

2.00e-03181895694
GeneFamilyEndogenous ligands|Minor histocompatibility antigens

WNK1 MTHFD1 SON

2.02e-0351893870
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZFHX4 TSHZ1

2.41e-0315892529
CoexpressionKAZMIN_PBMC_P_FALCIPARUM_RTSS_AS01_AGE_UNKNOWN_CORRELATED_WITH_PROTECTION_56DY_NEGATIVE

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

4.78e-09491317M40909
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#2_top-relative-expression-ranked_500

APC SALL4 ZCCHC14 ROBO2 ASXL2 NFAT5

1.25e-05891226gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_500_k2
DrugD-Au

KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5 VGLL1

2.90e-07771307CID000277822
DrugMetaraminol bitartrate [33402-03-8]; Down 200; 8.6uM; PC3; HT_HG-U133A

CYP3A4 APC ACAD10 LRRK1 THSD1 GPR107 KCNB1 OGA AKAP1

1.86e-0619513093669_DN
DrugAa1

KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS3 KIR2DS5

8.13e-06831306CID009549188
Drugdaunorubicin HCl; Up 200; 1uM; MCF7; HT_HG-U133A

ZNF821 TMEM144 HIVEP2 MID2 APC SNRK HIC2 TEX14

1.05e-0518313087507_UP
DrugHarmol hydrochloride monohydrate [40580-83-4]; Down 200; 15.8uM; MCF7; HT_HG-U133A

MID2 CYP3A4 ATAD5 ITSN1 GPR107 SETD2 ALMS1 CDC42EP2

1.61e-0519413082900_DN
DrugGemfibrozil [25812-30-0]; Up 200; 16uM; MCF7; HT_HG-U133A

TMEM144 HIC2 PFKFB2 TEX14 LRRN3 ALMS1 OGA AKAP1

1.73e-0519613082277_UP
DrugRifampicin [13292-46-1]; Up 200; 4.8uM; MCF7; HT_HG-U133A

ZNF821 HIC2 TEX14 THSD1 WNK1 ALMS1 AKAP1 NFAT5

1.73e-0519613082847_UP
DrugLY 294002; Up 200; 10uM; HL60; HT_HG-U133A

HIVEP2 APC ADARB1 CEP164 GPR107 NFAT5 SULT4A1 OR52A1

1.80e-0519713086198_UP
DrugTobramycin [32986-56-4]; Up 200; 8.6uM; MCF7; HT_HG-U133A

GNPTAB PFKFB2 WNK1 ADARB1 ZCCHC14 ZFHX4 DMRT1 DMWD

1.86e-0519813082841_UP
DrugLynestrenol [52-76-6]; Down 200; 14uM; MCF7; HT_HG-U133A

TMEM144 HIVEP2 CYP3A4 ACAD10 ALMS1 CDC42EP2 OGA SULT4A1

1.86e-0519813081537_DN
DrugBacampicillin hydrochloride [37661-08-8]; Down 200; 8uM; PC3; HT_HG-U133A

ATAD5 ESRRA APC WNK1 ADARB1 SVIL CDC42EP2 CSTF2T

1.86e-0519813084592_DN
DrugDibucaine [85-79-0]; Down 200; 11.6uM; PC3; HG-U133A

HIVEP2 MID2 APC HIC2 AZI2 FAF1 HMG20A OGA

1.93e-0519913081889_DN
Diseaselevel of killer cell immunoglobulin-like receptor 2DS2 in blood serum

KIR2DL1 KIR2DL3

5.24e-0531242OBA_2042107
DiseaseTorsades de Pointes

CYP3A4 SCN5A

5.24e-0531242C0040479
Diseasepuberty onset measurement

SEC16B SPEM3 JMJD1C AKAP1 NFAT5

1.90e-041251245EFO_0005677
Diseaseepididymis-specific alpha-mannosidase measurement

GNPTAB C1S

3.63e-0471242EFO_0801577
Diseasearylsulfatase K measurement

ARSK GNPTAB

4.82e-0481242EFO_0801395
Diseasediastolic blood pressure, systolic blood pressure

MAP1B CEP164 DHX15 ALMS1 KCNB1 SVIL SCN5A NFAT5 WDR62 TANGO6

5.46e-0467012410EFO_0006335, EFO_0006336
Diseasediffusing capacity of the lung for carbon monoxide

COL26A1 CFAP43 LRP1B CEP164

7.32e-04961244EFO_0009369
Diseasecancer antigen 125 measurement

MUC16 D2HGDH

7.71e-04101242EFO_0010603
Diseasesexual dimorphism measurement

SEC16B RAPGEF6 HIVEP2 ATAD5 APC JMJD1C CEP164 FAF1 NFATC2IP ASXL2 PGP CARNS1 GCN1

7.89e-04110612413EFO_0021796
DiseaseDNA repair protein RAD51 homolog 4 measurement

CYP3A4 TEX14

9.40e-04111242EFO_0801531
DiseaseN-acetylhistidine measurement

COL26A1 ALMS1

9.40e-04111242EFO_0800022
Diseasevisceral adipose tissue measurement

SEC16B HIVEP2 MCMDC2 WNK1 HMG20A ROBO2 CPNE4 NFAT5

9.96e-044811248EFO_0004765
Diseasecognitive function measurement

SEC16B CCDC146 TEX14 LRP1B JMJD1C DHX15 ZCCHC14 ZNF19 ALMS1 KCNB1 NFATC2IP CPNE3 SLC4A10 ASXL2 OGA

1.02e-03143412415EFO_0008354
Diseasemotion sickness

LRP1B TSHZ1 CPNE4

1.09e-03481243EFO_0006928
DiseaseEmery-Dreifuss muscular dystrophy (implicated_via_orthology)

LEMD3 LEMD1

1.12e-03121242DOID:11726 (implicated_via_orthology)
Diseasemethionine sulfone measurement

CYP3A4 ALMS1

1.12e-03121242EFO_0800072
Diseasegallstones

ANPEP JMJD1C UGDH NFAT5

1.14e-031081244EFO_0004210
DiseaseProstatic Neoplasms

CYP3A4 ITSN1 APC LRP1B SETD2 TXNDC5 CPNE3 ROBO2 TAF1L

1.20e-036161249C0033578
DiseaseMalignant neoplasm of prostate

CYP3A4 ITSN1 APC LRP1B SETD2 TXNDC5 CPNE3 ROBO2 TAF1L

1.20e-036161249C0376358
Disease5alpha-pregnan-3beta,20beta-diol monosulfate (1) measurement

CYP3A4 CARNS1

1.33e-03131242EFO_0800284
Diseasegallbladder cancer (is_implicated_in)

APC LRP1B

1.33e-03131242DOID:3121 (is_implicated_in)
Diseasekiller cell immunoglobulin-like receptor 2DS2 measurement

KIR2DL1 KIR2DL3

1.77e-03151242EFO_0801746
Diseaseanemia (implicated_via_orthology)

APC SLC4A10

1.77e-03151242DOID:2355 (implicated_via_orthology)
Diseaselanguage measurement

SEC16B COL26A1 CFAP54 DMRT1

2.50e-031341244EFO_0007797
Diseasetriglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement

SEC16B GARS1 JMJD1C FAF1 NFAT5

2.66e-032251245EFO_0008317, EFO_0020947
Diseasehippocampal tail volume

FAF1 SLC4A10

2.86e-03191242EFO_0009398
DiseaseProfound Mental Retardation

DOCK8 APC SLC4A10 WDR62

2.86e-031391244C0020796
DiseaseMental Retardation, Psychosocial

DOCK8 APC SLC4A10 WDR62

2.86e-031391244C0025363
DiseaseMental deficiency

DOCK8 APC SLC4A10 WDR62

2.86e-031391244C0917816
DiseaseIntellectual Disability

HIVEP2 MAP1B DOCK8 APC SETD2 SLC4A10 WDR62

2.88e-034471247C3714756
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

ANPEP PFKFB2 DHX15 SLC2A6 SLC52A2

3.45e-032391245EFO_0010934
Diseaseprothrombin time measurement

SLC19A2 JMJD1C

3.49e-03211242EFO_0008390

Protein segments in the cluster

PeptideGeneStartEntry
TYTRHPPLLPNGKAL

AZI2

281

Q9H6S1
SGPKRALPPKTLANY

ATAD5

1226

Q96QE3
PLPQNLSGYSLLPLS

ARSK

371

Q6UWY0
RTLPSIGPPSILAYK

ERICH6

236

Q7L0X2
NYSVGSRPLKPLSPL

PFKFB2

481

O60825
SGINYDKPLPPIQVA

EP400

2501

Q96L91
KELNLTNIYAPPLPS

AKAP1

676

Q92667
QSLPKDLIYGPVLPL

CFAP43

216

Q8NDM7
LPLAVFYGPLDAKNP

CFAP54

56

Q96N23
KVKPQPPLSDAYLSG

BAG6

1031

P46379
PGKFYSPLPNDQLLK

BAZ2B

1536

Q9UIF8
YSSKPPLDLAASPGL

CALHM3

306

Q86XJ0
SRGTDGQPLLLPYKP

ALMS1

3256

Q8TCU4
LPQIKLYGPTNFSPI

CPNE3

386

O75131
PATLAFTYKPPGLLR

CARNS1

106

A5YM72
CPGLIYKDPSLPGLE

ACAD10

366

Q6JQN1
YPLPKSDQIGLPDFN

ANPEP

336

P15144
DVYGNDSLIPKPPNS

C7orf31

121

Q8N865
GDIKIIPLYSTLPPQ

DHX15

381

O43143
LASPYLPEGTSKPLS

CAMSAP3

496

Q9P1Y5
APLSPLPKAGSITYR

DMWD

416

Q09019
DPKDQLLLGPTYATP

HADHB

346

P55084
TEPPTESLLLRKPYG

ATP2B3

901

Q16720
LQTPKLYGSPTQIGP

ASXL2

1311

Q76L83
RKPLLPYTPGSDVAG

CRYZ

61

Q08257
PDSYLSAGEIPLPKL

GPR107

251

Q5VW38
YEKPSLSAQPGPTVL

KIR2DS2

126

P43631
TPVKQDLSAPPGYTL

MTCL1

1831

Q9Y4B5
FSPGPILPSTRKLYE

LEMD1

21

Q68G75
QYRGLKAPPAPLAAS

LEMD3

166

Q9Y2U8
PLPVSPSDDKALGYQ

PM20D1

396

Q6GTS8
YLPDAVKGLPLPASL

ASB8

266

Q9H765
CTYLQPLSGPGLPIK

MUC16

13996

Q8WXI7
YEKPSLSAQPGPTVL

KIR2DL2

126

P43627
TAPPIYLNSDLKGPL

LRP1B

4536

Q9NZR2
KSSAVPPGLPVYLDL

MAP1B

2346

P46821
KLTHLPPLPSYGLDL

MCMDC2

101

Q4G0Z9
PANITLKDLPSLYPS

GNPTAB

146

Q3T906
YEKPSLSAQPGPTVL

KIR2DL3

126

P43628
NDSYLLPHLLPSKPG

LRRK1

986

Q38SD2
PLRDSNAPKSPLTGY

HMG20A

96

Q9NP66
LLKSLPLPEYCNPEG

JMJD1C

2281

Q15652
PTPLPFLGNILSYHK

CYP3A4

41

P08684
VPPFLNPLVYGAKTT

OR52A1

286

Q9UKL2
APAPKAYVLGSPALA

PGP

116

A6NDG6
YEKPSLSAQPGPTVL

KIR2DS3

126

Q14952
LKPSTAYAPEGSPIL

FAHD1

46

Q6P587
LAPYLPSVTPGLKAS

GCN1

1651

Q92616
PAKYLSLALDEPPCG

OLIG1

216

Q8TAK6
PPLYTLNKPLLSGIS

ADARB1

611

P78563
PLAAPAGYLTLVPLL

SLC2A6

386

Q9UGQ3
SVYDLLPKELQLPPS

NFAT5

26

O94916
AAIPLPLVKSLLGPY

NAT10

391

Q9H0A0
YEKPSLSAQPGPTVL

KIR2DS5

126

Q14953
LLYSVDSSPPKSLPG

KCNB1

766

Q14721
LPDGPSPLLKNAISL

CDC42EP2

96

O14613
PKSGAPTALLDPRSY

DOCK8

866

Q8NF50
ADILKPVNPYTGLPV

FBXO15

171

Q8NCQ5
LLKPPSQGELPGTEY

FRMPD3

1286

Q5JV73
CLPKLQLYGPTNIAP

CPNE4

401

Q96A23
KLKLQGYQLPSALPP

ITSN1

86

Q15811
TAPPSGLKKYEEPLQ

BCL9L

456

Q86UU0
TALIGEIASPNYPKP

C1S

181

P09871
LLPAFENTKTGIPYP

EDEM1

271

Q92611
DPTPNLKRLSNLPGY

MACC1

506

Q6ZN28
LKSLGPAAPIIDSPY

CSTF2T

101

Q9H0L4
GPKDNPLALQDYTPS

ENAM

881

Q9NRM1
LPKNNSLYVLTPDLP

FAF1

161

Q9UNN5
IPSAPPLYLDSGNKT

CCDC168

5556

Q8NDH2
ALPKVTLPNYDNVPG

CLIP3

271

Q96DZ5
IAPNKPEQGSYLPVL

C4orf54

1206

D6RIA3
PFLTPYLLGPDKNLT

SLC19A2

51

O60779
SEPFLIPYLSGPDKN

SLC19A3

31

Q9BZV2
LPPTPQDISYLAKGK

SALL4

161

Q9UJQ4
LYIKAEPASPDSPKG

ESRRA

11

P11474
YEKPSLSAQPGPTVL

KIR2DL1

126

P43626
QSSPAKEGPLDLYPK

PPRC1

546

Q5VV67
PTVTAGLPLPKAYIQ

MTHFD1

711

P11586
PQGALYSLQPPTDKD

COL26A1

271

Q96A83
LKDLAPGTNPPFLVY

CLIC2

61

O15247
DPKGILNPYKTLPSQ

D2HGDH

506

Q8N465
SPVKNSLRGLPGPYV

DMRT1

251

Q9Y5R6
GSVYEPLKSINLPRP

PHKB

26

Q93100
YEKPSLSAQPGPTVL

KIR2DS1

126

Q14954
LRSPDPGILAYKPGS

PNPLA8

246

Q9NP80
YTGKLLPSDQPAEPN

HIC2

101

Q96JB3
PTPPGYLGISLADLK

RAPGEF6

1506

Q8TEU7
LPPSSYDADQKPGLE

SCRT2

51

Q9NQ03
NAYKLPLAVGPPSLN

TEX14

786

Q8IWB6
FTGPPQLQALKYKDP

SVIL

551

O95425
LQKPTFALGELYPPL

LRRN3

666

Q9H3W5
GPNEKPLYTAEPVTL

OGA

541

O60502
RPPLKKYSFGALSQP

TAF1L

636

Q8IZX4
YNVKSPITGNDLSPP

GARS1

261

P41250
TPGPDPKAYQLLSAR

SLC52A2

261

Q9HAB3
SKKLPDLYGNPPQEL

SCN5A

61

Q14524
LIPDDLSLLKLYPPG

NFATC2IP

136

Q8NCF5
GVDPSPATKYNIPLV

SNRK

271

Q9NRH2
AKGPLASQISGLYLP

NT5E

146

P21589
NAYIPEADATLPLPK

CCDC146

911

Q8IYE0
EADATLPLPKPYGAL

CCDC146

916

Q8IYE0
KLPPNLSPTIEYNDG

APC

2506

P25054
RKYFPSGIPLLSNSP

CEP164

1361

Q9UPV0
LTSLPPNYEISEGKP

CLLU1-AS1

51

Q5K130
SLGKNYKEPEPAPNS

VGLL4

216

Q14135
NSPTLPIYEPGLKEV

UGDH

46

O60701
IPYAPSGEIPKFSLQ

UGDH

471

O60701
EGKQAGYSLPPSPLI

ZFHX4

2656

Q86UP3
PYPDLAGPRKALSQL

ZNF287

56

Q9HBT7
TALGYPVPKPALISL

ZNF19

51

P17023
TKPPLAPGTILYEAE

NIBAN1

61

Q9BZQ8
PDLYKNPGLTQDPGL

SPEM3

696

A0A1B0GUW6
YPQPGLDIIKELTSP

SULT4A1

91

Q9BR01
NSPKLYPEAVLPGFL

TMEM144

256

Q7Z5S9
PKSYTLGQPLRKPDL

THSD1

726

Q9NS62
DYAIGIPSPKLQVPS

SLC4A10

776

Q6U841
LLPLLEKVSNTYPDP

TANGO6

721

Q9C0B7
TISKNYDLSDLPGPP

ROBO2

511

Q9HCK4
YVDPSNPNAGKVLLP

SETD2

2176

Q9BYW2
PALKGAVPLYNPSQV

SEC16B

1021

Q96JE7
PTLYPLASPDLQALL

WDR62

1486

O43379
PGTFRLKYAPPAESL

ZCCHC14

931

Q8WYQ9
TPSKPSGLSLLPDYE

ZNF830

146

Q96NB3
LKNTSGLLYPPEAPE

TRAPPC8

406

Q9Y2L5
PPSAPELKQGLYELS

TXNDC5

181

Q8NBS9
KDIAFSPPVYPAGIL

ZNF821

221

O75541
LSLLPPAYNKPSISL

STRADB

381

Q9C0K7
LLQPLKPSPSSDNLY

WNK1

2181

Q9H4A3
KLLEGLDYLTAPNPP

MID2

391

Q9UJV3
APIPGSPLYTIKAFI

EFTUD2

861

Q15029
PKSGIPLPNESSQYI

HIVEP2

331

P31629
LSELETPGKYSLTPP

VGLL1

231

Q99990
LGSKSPDPYRLAQDP

SON

906

P18583
AAYQLPGTVKPLPAA

TSHZ1

581

Q6ZSZ6
PSPNAPLKRVLAYTG

USP32

626

Q8NFA0