Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphoric ester hydrolase activity	MINPP1 PTPRD CHRM3 PPP1CA PPP1CC	3.45e-04	386	32	5	GO:0042578
GeneOntologyMolecularFunction	histone modifying activity	JADE1 BAZ1A UTY SUV39H1	4.71e-04	229	32	4	GO:0140993
GeneOntologyMolecularFunction	phosphatase activity	MINPP1 PTPRD PPP1CA PPP1CC	1.09e-03	287	32	4	GO:0016791
GeneOntologyMolecularFunction	protein phosphatase 1 binding	PPP1CA PPP1CC	1.43e-03	35	32	2	GO:0008157
GeneOntologyMolecularFunction	histone acetyltransferase activity	JADE1 BAZ1A	3.02e-03	51	32	2	GO:0004402
GeneOntologyMolecularFunction	phosphoprotein phosphatase activity	PTPRD PPP1CA PPP1CC	3.38e-03	189	32	3	GO:0004721
GeneOntologyMolecularFunction	peptide-lysine-N-acetyltransferase activity	JADE1 BAZ1A	3.50e-03	55	32	2	GO:0061733
GeneOntologyMolecularFunction	peptide N-acetyltransferase activity	JADE1 BAZ1A	4.16e-03	60	32	2	GO:0034212
GeneOntologyMolecularFunction	protein phosphatase binding	SMG5 PPP1CA PPP1CC	4.54e-03	210	32	3	GO:0019903
GeneOntologyCellularComponent	PTW/PP1 phosphatase complex	PPP1CA PPP1CC	4.74e-05	7	32	2	GO:0072357
GeneOntologyCellularComponent	protein phosphatase type 1 complex	PPP1CA PPP1CC	3.82e-04	19	32	2	GO:0000164
GeneOntologyCellularComponent	somatodendritic compartment	WDFY3 COPA ABI3BP CHRM3 CAPN2 PPP1CA PPP1CC NEDD4	4.11e-04	1228	32	8	GO:0036477
GeneOntologyCellularComponent	dendritic spine	ABI3BP PPP1CA PPP1CC NEDD4	4.88e-04	242	32	4	GO:0043197
GeneOntologyCellularComponent	transferase complex	WDFY3 JADE1 FNTA PIK3C2B UTY EPC1 NEDD4	5.27e-04	963	32	7	GO:1990234
GeneOntologyCellularComponent	neuron spine	ABI3BP PPP1CA PPP1CC NEDD4	5.27e-04	247	32	4	GO:0044309
GeneOntologyCellularComponent	dendrite	ABI3BP CHRM3 CAPN2 PPP1CA PPP1CC NEDD4	1.70e-03	858	32	6	GO:0030425
GeneOntologyCellularComponent	dendritic tree	ABI3BP CHRM3 CAPN2 PPP1CA PPP1CC NEDD4	1.73e-03	860	32	6	GO:0097447
Domain	STPPase_N	PPP1CA PPP1CC	7.99e-06	3	31	2	PF16891
Domain	STPPase_N	PPP1CA PPP1CC	7.99e-06	3	31	2	IPR031675
Domain	Enhancer_polycomb-like_N	JADE1 EPC1	7.42e-05	8	31	2	IPR019542
Domain	EPL1	JADE1 EPC1	7.42e-05	8	31	2	PF10513
Domain	Ser/Thr-sp_prot-phosphatase	PPP1CA PPP1CC	2.06e-04	13	31	2	IPR006186
Domain	SER_THR_PHOSPHATASE	PPP1CA PPP1CC	2.06e-04	13	31	2	PS00125
Domain	PP2Ac	PPP1CA PPP1CC	2.06e-04	13	31	2	SM00156
Domain	FN3	NCAM2 POMGNT2 PTPRD ABI3BP	3.14e-04	199	31	4	PS50853
Domain	FN3_dom	NCAM2 POMGNT2 PTPRD ABI3BP	3.78e-04	209	31	4	IPR003961
Domain	Calcineurin-like_PHP_ApaH	PPP1CA PPP1CC	9.81e-04	28	31	2	IPR004843
Domain	Metallophos	PPP1CA PPP1CC	9.81e-04	28	31	2	PF00149
Domain	Metallo-depent_PP-like	PPP1CA PPP1CC	1.13e-03	30	31	2	IPR029052
Domain	-	PPP1CA PPP1CC	1.13e-03	30	31	2	3.60.21.10
Domain	C2	MYOF PIK3C2B NEDD4	1.31e-03	131	31	3	PF00168
Domain	C2	MYOF PIK3C2B NEDD4	1.49e-03	137	31	3	SM00239
Domain	C2	MYOF PIK3C2B NEDD4	1.65e-03	142	31	3	PS50004
Domain	Znf_FYVE_PHD	WDFY3 JADE1 BAZ1A	1.83e-03	147	31	3	IPR011011
Domain	-	MYOF PIK3C2B NEDD4	1.86e-03	148	31	3	2.60.40.150
Domain	fn3	NCAM2 PTPRD ABI3BP	2.41e-03	162	31	3	PF00041
Domain	C2_dom	MYOF PIK3C2B NEDD4	2.49e-03	164	31	3	IPR000008
Domain	FN3	NCAM2 PTPRD ABI3BP	3.50e-03	185	31	3	SM00060
Domain	Zinc_finger_PHD-type_CS	JADE1 BAZ1A	5.20e-03	65	31	2	IPR019786
Domain	-	RNF213 WDFY3 JADE1 BAZ1A	6.20e-03	449	31	4	3.30.40.10
Domain	Znf_RING/FYVE/PHD	RNF213 WDFY3 JADE1 BAZ1A	6.70e-03	459	31	4	IPR013083
Domain	PHD	JADE1 BAZ1A	6.86e-03	75	31	2	PF00628
Domain	Znf_PHD-finger	JADE1 BAZ1A	7.59e-03	79	31	2	IPR019787
Domain	PHD	JADE1 BAZ1A	9.54e-03	89	31	2	SM00249
Domain	Znf_PHD	JADE1 BAZ1A	9.96e-03	91	31	2	IPR001965
Domain	ZF_PHD_2	JADE1 BAZ1A	1.08e-02	95	31	2	PS50016
Domain	ZF_PHD_1	JADE1 BAZ1A	1.10e-02	96	31	2	PS01359
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_MRAS_SHOC2_PP1_HOLOPHOSPHATASE	PPP1CA PPP1CC	1.22e-04	8	30	2	M47933
Pathway	KEGG_MEDICUS_REFERENCE_CENPE_INTERACTION_WITH_NDC80_COMPLEX	PPP1CA PPP1CC	2.85e-04	12	30	2	M47887
Pathway	KEGG_MEDICUS_REFERENCE_DEPHOSPHORYLATION_OF_KINETOCHORE	PPP1CA PPP1CC	2.85e-04	12	30	2	M47891
Pathway	REACTOME_CIRCADIAN_CLOCK	DBP PPP1CA PPP1CC	4.32e-04	70	30	3	M938
Pathway	REACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_RSV_GENOME_REPLICATION_TRANSCRIPTION_AND_TRANSLATION	PPP1CA PPP1CC	5.16e-04	16	30	2	M48235
Pubmed	Spermiogenesis is impaired in mice bearing a targeted mutation in the protein phosphatase 1cgamma gene.	PPP1CA PPP1CC	8.20e-07	2	32	2	9882500
Pubmed	PP-1α and PP-1γ display antagonism and differential roles in tumorigenicity of lung cancer cells.	PPP1CA PPP1CC	8.20e-07	2	32	2	23176181
Pubmed	KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation.	JADE1 SUV39H1 EPC1	9.30e-07	21	32	3	27270040
Pubmed	The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation.	PPP1CA PPP1CC	2.46e-06	3	32	2	12138106
Pubmed	Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization.	PPP1CA PPP1CC	2.46e-06	3	32	2	7857673
Pubmed	Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells.	PPP1CA PPP1CC	2.46e-06	3	32	2	11739654
Pubmed	Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network.	PPP1CA PPP1CC	2.46e-06	3	32	2	19074462
Pubmed	Myr 8, a novel unconventional myosin expressed during brain development associates with the protein phosphatase catalytic subunits 1alpha and 1gamma1.	PPP1CA PPP1CC	2.46e-06	3	32	2	11588169
Pubmed	1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription.	PPP1CA PPP1CC	2.46e-06	3	32	2	25073485
Pubmed	Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.	PPP1CA PPP1CC	2.46e-06	3	32	2	21712997
Pubmed	NOM1 targets protein phosphatase I to the nucleolus.	PPP1CA PPP1CC	2.46e-06	3	32	2	17965019
Pubmed	Characterization of protein phosphatases in mouse oocytes.	PPP1CA PPP1CC	2.46e-06	3	32	2	9882488
Pubmed	Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling.	PPP1CA PPP1CC	4.92e-06	4	32	2	23499489
Pubmed	Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein.	PPP1CA PPP1CC	4.92e-06	4	32	2	16131488
Pubmed	Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1.	PPP1CA PPP1CC	4.92e-06	4	32	2	10194355
Pubmed	Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx.	PPP1CA PPP1CC	4.92e-06	4	32	2	23277204
Pubmed	NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1.	PPP1CA PPP1CC	4.92e-06	4	32	2	10880350
Pubmed	The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits.	PPP1CA PPP1CC	4.92e-06	4	32	2	12016225
Pubmed	Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation.	PPP1CA PPP1CC	4.92e-06	4	32	2	12221103
Pubmed	Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis.	PPP1CA PPP1CC	4.92e-06	4	32	2	15226296
Pubmed	Small molecules targeted to a non-catalytic "RVxF" binding site of protein phosphatase-1 inhibit HIV-1.	PPP1CA PPP1CC	4.92e-06	4	32	2	22768081
Pubmed	Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.	PPP1CA PPP1CC	4.92e-06	4	32	2	12226088
Pubmed	Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation.	PPP1CA PPP1CC	4.92e-06	4	32	2	17202132
Pubmed	Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif.	PPP1CA PPP1CC	4.92e-06	4	32	2	10807923
Pubmed	A vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand.	PPP1CA PPP1CC	4.92e-06	4	32	2	12036952
Pubmed	N-CoR controls differentiation of neural stem cells into astrocytes.	PPP1CA PPP1CC	4.92e-06	4	32	2	12410313
Pubmed	Synphilin-1A is a phosphoprotein phosphatase 1-interacting protein and affects PPP1 sorting to subcellular compartments.	PPP1CA PPP1CC	4.92e-06	4	32	2	24902662
Pubmed	Nuclear protein phosphatase-1 regulates HIV-1 transcription.	PPP1CA PPP1CC	4.92e-06	4	32	2	12788939
Pubmed	Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions.	DBP PPP1CA PPP1CC	6.83e-06	40	32	3	23555304
Pubmed	SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1.	PPP1CA PPP1CC	8.19e-06	5	32	2	20424263
Pubmed	Distinct roles for the α , β and γ1 isoforms of protein phosphatase 1 in the outside-in αIIbβ3 integrin signalling-dependent functions.	PPP1CA PPP1CC	8.19e-06	5	32	2	23197154
Pubmed	Initiation factor 2B activity is regulated by protein phosphatase 1, which is activated by the mitogen-activated protein kinase-dependent pathway in insulin-like growth factor 1-stimulated neuronal cells.	PPP1CA PPP1CC	8.19e-06	5	32	2	12624094
Pubmed	Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions.	PPP1CA PPP1CC	8.19e-06	5	32	2	19581931
Pubmed	The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity.	PPP1CA PPP1CC	8.19e-06	5	32	2	12016208
Pubmed	Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores.	PPP1CA PPP1CC	8.19e-06	5	32	2	22801782
Pubmed	Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle.	PPP1CA PPP1CC	8.19e-06	5	32	2	11551964
Pubmed	The heterotrimeric G protein Gβ1 interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein-coupled receptor signaling in platelets.	PPP1CA PPP1CC	8.19e-06	5	32	2	28615442
Pubmed	Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220.	PPP1CA PPP1CC	8.19e-06	5	32	2	10209101
Pubmed	The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors.	PPP1CA PPP1CC	8.19e-06	5	32	2	17511879
Pubmed	A PP1-PP2A phosphatase relay controls mitotic progression.	PPP1CA PPP1CC	8.19e-06	5	32	2	25487150
Pubmed	The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate.	PPP1CA PPP1CC	8.19e-06	5	32	2	24116158
Pubmed	Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1).	PPP1CA PPP1CC	1.23e-05	6	32	2	25785436
Pubmed	Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motif.	PPP1CA PPP1CC	1.23e-05	6	32	2	21998301
Pubmed	Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins.	PPP1CA PPP1CC	1.23e-05	6	32	2	23088536
Pubmed	Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3.	PPP1CA PPP1CC	1.23e-05	6	32	2	18641122
Pubmed	SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1.	PPP1CA PPP1CC	1.23e-05	6	32	2	14640981
Pubmed	Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality.	PPP1CA PPP1CC	1.72e-05	7	32	2	18689497
Pubmed	SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein.	PPP1CA PPP1CC	1.72e-05	7	32	2	17123353
Pubmed	Mutation of SPINOPHILIN (PPP1R9B) found in human tumors promotes the tumorigenic and stemness properties of cells.	PPP1CA PPP1CC	1.72e-05	7	32	2	33537097
Pubmed	A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta.	PPP1CA PPP1CC	1.72e-05	7	32	2	12147701
Pubmed	Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex.	PPP1CA PPP1CC	1.72e-05	7	32	2	10637318
Pubmed	A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat.	PPP1CA PPP1CC	2.29e-05	8	32	2	12036313
Pubmed	Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.	PPP1CA PPP1CC	2.29e-05	8	32	2	16262633
Pubmed	The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1.	PPP1CA PPP1CC	2.29e-05	8	32	2	21930935
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	MFAP1 MYOF COPA BAZ1A PPP1CA PPP1CC	2.72e-05	660	32	6	32780723
Pubmed	RRP1B targets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits.	PPP1CA PPP1CC	2.94e-05	9	32	2	20926688
Pubmed	Consensus PP1 binding motifs regulate transcriptional corepression and alternative RNA splicing activities of the steroid receptor coregulators, p54nrb and PSF.	PPP1CA PPP1CC	2.94e-05	9	32	2	21566083
Pubmed	Identification of the human testis protein phosphatase 1 interactome.	MAP4K4 PPP1CA PPP1CC	3.40e-05	68	32	3	21382349
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	MFAP1 PPP1CA PPP1CC NEDD4	3.56e-05	203	32	4	22083510
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	MYOF SMG5 WDFY3 DOCK9	5.32e-05	225	32	4	12168954
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MYOF SMG5 WDFY3 JADE1 POMGNT2 PIK3C2B DOCK9	5.38e-05	1105	32	7	35748872
Pubmed	The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1.	MAP4K4 PPP1CA	5.38e-05	12	32	2	35027733
Pubmed	PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.	PPP1CA PPP1CC	5.38e-05	12	32	2	10830164
Pubmed	Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch.	MYOF NEDD4	6.36e-05	13	32	2	23146885
Pubmed	Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription.	PPP1CA PPP1CC	7.41e-05	14	32	2	16048649
Pubmed	Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.	MYOF COPA PPP1CA	7.61e-05	89	32	3	27034005
Pubmed	BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.	PPP1CA PPP1CC	8.55e-05	15	32	2	12931191
Pubmed	Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance.	PPP1CA PPP1CC	9.76e-05	16	32	2	17683050
Pubmed	Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases.	PPP1CC NEDD4	9.76e-05	16	32	2	21920314
Pubmed	Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to Promote Progression and Paclitaxel Resistance in Triple-Negative Breast Cancer.	PPP1CA PPP1CC	9.76e-05	16	32	2	36484700
Pubmed	Regulation of HIV-1 transcription by protein phosphatase 1.	PPP1CA PPP1CC	1.11e-04	17	32	2	17266553
Pubmed	[Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors].	PPP1CA PPP1CC	1.11e-04	17	32	2	21351466
Pubmed	Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.	PIK3C2B PPP1CA PPP1CC	1.18e-04	103	32	3	21706016
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SMG5 DOCK9 AGAP1	1.21e-04	104	32	3	10470851
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	NCAM2 AGAP1 PPP1CA NEDD4	1.26e-04	281	32	4	28706196
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	NCAM2 SMG5 WDFY3 PTPRD COPA MAP4K4 AGAP1	1.38e-04	1285	32	7	35914814
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	MFAP1 COPA MAP4K4 NEDD4	1.90e-04	313	32	4	38270169
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	MFAP1 WDFY3 COPA BAZ1A CAPN2 PPP1CA PPP1CC	1.90e-04	1353	32	7	29467282
Pubmed	New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC).	PPP1CA PPP1CC	2.05e-04	23	32	2	21360054
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	WDFY3 PTPRD MAP4K4 PPP1CA PPP1CC NEDD4	2.17e-04	963	32	6	28671696
Pubmed	Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human.	WDFY3 UTY	2.24e-04	24	32	2	17452356
Pubmed	Hepatic Glucocorticoid Receptor Plays a Greater Role Than Adipose GR in Metabolic Syndrome Despite Renal Compensation.	PPP1CA PPP1CC	2.24e-04	24	32	2	27754788
Pubmed	Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs.	PPP1CA NEDD4	2.24e-04	24	32	2	37100772
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	RNF213 COPA BAZ1A PPP1CC	2.37e-04	332	32	4	32786267
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	MFAP1 COPA SUV39H1 PPP1CA	2.60e-04	340	32	4	29478914
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	RNF213 MFAP1 COPA BAZ1A CAPN2 PPP1CA	2.86e-04	1014	32	6	32416067
Pubmed	Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.	RNF213 MYOF COPA	3.16e-04	144	32	3	35681168
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	MFAP1 MAP4K4 CAPN2 PPP1CA PPP1CC	3.42e-04	670	32	5	22990118
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	PPP1CA PPP1CC	3.75e-04	31	32	2	20516061
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	MYOF MAP4K4 DOCK9 AGAP1	3.84e-04	377	32	4	38117590
Pubmed	Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.	ABI3BP MAP4K4 BAZ1A	3.99e-04	156	32	3	22952844
Pubmed	The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle.	CAPN2 NEDD4	4.00e-04	32	32	2	36278411
Pubmed	A quantitative telomeric chromatin isolation protocol identifies different telomeric states.	PPP1CA PPP1CC	4.52e-04	34	32	2	24270157
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	MYOF SMG5 COPA PPP1CA PPP1CC	4.87e-04	724	32	5	36232890
Pubmed	Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.	MFAP1 PIK3C2B PPP1CA	5.04e-04	169	32	3	31462741
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	POMGNT2 MAP4K4 DOCK9 CAPN2 PPP1CA PPP1CC	5.32e-04	1139	32	6	36417873
Pubmed	Cellular substrates and pro-apoptotic function of the human HtrA4 protease.	CAPN2 PPP1CA PPP1CC	5.40e-04	173	32	3	31470122
Pubmed	ZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2.	PPP1CA PPP1CC	5.65e-04	38	32	2	30629181
Pubmed	ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.	JADE1 EPC1	6.90e-04	42	32	2	16387653
Pubmed	A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.	PPP1CA PPP1CC	9.01e-04	48	32	2	17274640
Interaction	PRR16 interactions	PPP1CA PPP1CC NEDD4	2.01e-06	16	32	3	int:PRR16
Interaction	TANC2 interactions	MAP4K4 AGAP1 PPP1CA PPP1CC	1.16e-05	89	32	4	int:TANC2
Interaction	PPP1R2C interactions	PPP1CA PPP1CC	1.46e-05	4	32	2	int:PPP1R2C
Interaction	CSRNP2 interactions	PPP1CA PPP1CC	2.44e-05	5	32	2	int:CSRNP2
Interaction	TNIK interactions	PTPRD FNTA MAP4K4 PPP1CA PPP1CC NEDD4	2.62e-05	381	32	6	int:TNIK
Interaction	SFRP5 interactions	PPP1CA PPP1CC	3.65e-05	6	32	2	int:SFRP5
Interaction	WBP1 interactions	POMGNT2 COPA NEDD4	4.00e-05	42	32	3	int:WBP1
Interaction	YWHAG interactions	MFAP1 NCAM2 PIK3C2B MAP4K4 BAZ1A DOCK9 AGAP1 PPP1CA NEDD4	9.95e-05	1248	32	9	int:YWHAG
Interaction	PPP1R16A interactions	SUV39H1 PPP1CA PPP1CC	1.00e-04	57	32	3	int:PPP1R16A
Interaction	POLR3A interactions	CAPN2 PPP1CA PPP1CC NEDD4	1.24e-04	163	32	4	int:POLR3A
Interaction	RELT interactions	RNF213 MYOF PTPRD	1.49e-04	65	32	3	int:RELT
Interaction	YWHAZ interactions	MFAP1 NCAM2 WDFY3 PIK3C2B DOCK9 AGAP1 PPP1CA PPP1CC NEDD4	1.52e-04	1319	32	9	int:YWHAZ
Interaction	PPP1R1B interactions	PPP1CA PPP1CC	1.60e-04	12	32	2	int:PPP1R1B
Cytoband	Ensembl 112 genes in cytogenetic band chr10q23	MYOF MINPP1	8.19e-03	195	32	2	chr10q23
GeneFamily	Protein phosphatase catalytic subunits\|EF-hand domain containing	PPP1CA PPP1CC	1.66e-04	13	27	2	693
GeneFamily	Fibronectin type III domain containing	NCAM2 PTPRD ABI3BP	1.70e-03	160	27	3	555
GeneFamily	PHD finger proteins	JADE1 BAZ1A	7.93e-03	90	27	2	88
Coexpression	FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP	MYOF WDFY3 MINPP1 PTPRD COPA FNTA	5.66e-05	568	32	6	M4023
Coexpression	LAKE_ADULT_KIDNEY_C4_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S2	RNF213 WDFY3 PTPRD AGAP1	6.10e-05	176	32	4	M39223
Coexpression	GSE21546_SAP1A_KO_VS_SAP1A_KO_AND_ELK1_KO_ANTI_CD3_STIM_DP_THYMOCYTES_UP	WDFY3 MINPP1 ACSS1 AGAP1	1.00e-04	200	32	4	M7525
Coexpression	GSE21379_TFH_VS_NON_TFH_SAP_KO_CD4_TCELL_UP	WDFY3 MINPP1 CHRM3 AGAP1	1.00e-04	200	32	4	M7516
Coexpression	GSE21670_IL6_VS_TGFB_AND_IL6_TREATED_STAT3_KO_CD4_TCELL_UP	COPA AP1S3 SUV39H1 CAPN2	1.00e-04	200	32	4	M7449
Coexpression	GSE42021_TREG_PLN_VS_CD24HI_TREG_THYMUS_DN	DBP FNTA ACSS1 EPC1	1.00e-04	200	32	4	M9613
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	RNF213 PIK3C2B MAP4K4 DOCK9 NEDD4	3.02e-07	200	32	5	3585484c7e24e941708bee471ca607d8ccee74e6
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ABI3BP PIK3C2B CHRM3 DOCK9	7.99e-06	179	32	4	1ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ABI3BP PIK3C2B DOCK9 NEDD4	9.09e-06	185	32	4	a7ae76058b2082020cadec49d63b9f4e24d21734
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RNF213 PIK3C2B DOCK9 NEDD4	9.49e-06	187	32	4	f3397dbc23b6c2f24e2c1ba887d8f9aef3ee01a1
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABI3BP PIK3C2B CHRM3 DOCK9	9.69e-06	188	32	4	c2c51c6526defe2600302901159b8abbb58d7595
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABI3BP PIK3C2B CHRM3 DOCK9	9.89e-06	189	32	4	12b6f1c3bf526b90e112374bf937701f645c5780
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABI3BP PIK3C2B CHRM3 DOCK9	1.01e-05	190	32	4	bf9bc57a605c7e3979bc4f7260e6fb92c3eb8690
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ABI3BP PIK3C2B DOCK9 NEDD4	1.01e-05	190	32	4	f6c38d197fd9d69a4f97cb2e72cd4747984c1a86
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABI3BP PIK3C2B CHRM3 DOCK9	1.03e-05	191	32	4	b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCell	RV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	NCAM2 JADE1 PTPRD ABI3BP	1.03e-05	191	32	4	70c067c54084bfb02c29bab085f4defd477194fb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABI3BP PIK3C2B CHRM3 DOCK9	1.07e-05	193	32	4	0b328f725f6feba263783eaca60c142e80df90f3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABI3BP PIK3C2B CHRM3 DOCK9	1.07e-05	193	32	4	2e72309607902dabe3218888b22a77fe941f3570
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RNF213 MYOF ABI3BP AP1S3	1.10e-05	194	32	4	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABI3BP PIK3C2B CHRM3 DOCK9	1.10e-05	194	32	4	b0c15e7e4bcf30856fb628dedd7ba82df33489f5
ToppCell	RV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	NCAM2 JADE1 PTPRD ABI3BP	1.12e-05	195	32	4	ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABI3BP PIK3C2B CHRM3 DOCK9	1.12e-05	195	32	4	77e47d2e8b3eb7f7c9620369ccaf87581f923bdb
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3C2B CHRM3 DOCK9 NEDD4	1.14e-05	196	32	4	b8f89a50114932c08fc5daac4b549adfe9df8e66
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COPA MAP4K4 CAPN2 NEDD4	1.14e-05	196	32	4	151f1a29a91f8b234e9b6ed062666357a2f69128
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3C2B CHRM3 DOCK9 NEDD4	1.14e-05	196	32	4	d0ff1082898d2db47c88d2678466514e9e9193d3
ToppCell	facs-Trachea-3m\|Trachea / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COPA MAP4K4 CAPN2 NEDD4	1.16e-05	197	32	4	e77016d64b1cac9825fec7cfe5071f1567401187
ToppCell	facs-Trachea-nan-3m\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COPA MAP4K4 CAPN2 NEDD4	1.16e-05	197	32	4	0353d925ee4b7aefc2c51b5fab873f465cdf9ebc
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19-Macroglial-Astrocyte\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	RNF213 NCAM2 DBP ACSS1	1.19e-05	198	32	4	bfad1c51cf884ff7ce89f8278820800582541dc7
ToppCell	Fibroblasts-DKK3+_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	MYOF PTPRD ABI3BP AGAP1	1.19e-05	198	32	4	4f4632f26a2043c5e4ab89031b4229b5dca1bd48
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19-Macroglial\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	RNF213 NCAM2 DBP ACSS1	1.19e-05	198	32	4	6372e65242236c497d9b3be147092897c1609d22
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABI3BP PIK3C2B CHRM3 DOCK9	1.21e-05	199	32	4	a3ec743b978ba8fdf1677b4971b5731f50ddd30f
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	WDFY3 CHRM3 UTY AGAP1	1.21e-05	199	32	4	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABI3BP PIK3C2B CHRM3 DOCK9	1.21e-05	199	32	4	9b02acae6325b0ac9642438a4431285ff396e5fe
ToppCell	facs-Trachea-nan-3m-Mesenchymal\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COPA ABI3BP CAPN2 NEDD4	1.21e-05	199	32	4	67f78c070c56e44fba36542041bf7fa1c291807c
ToppCell	facs-Trachea-nan-3m-Mesenchymal-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COPA ABI3BP CAPN2 NEDD4	1.21e-05	199	32	4	1ae244b563f85c1ee8d22698f478c842a4d9c7f5
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	RNF213 PIK3C2B DOCK9 NEDD4	1.24e-05	200	32	4	edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	RNF213 MAP4K4 DOCK9 NEDD4	1.24e-05	200	32	4	89821a264e872ed53e08e9d3609d5cc5c314503e
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Adora2a-Excitatory_Neuron.Gad1Gad2.Adora2a-Nefm_(iSPN)-\|Striatum / BrainAtlas - Mouse McCarroll V32	ABI3BP CHRM3 PPP1CA	2.79e-05	82	32	3	d5f8f5aad7e41d1151772d1ca2415a9d0722c98a
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Adora2a-Excitatory_Neuron.Gad1Gad2.Adora2a-Nefm_(iSPN)\|Striatum / BrainAtlas - Mouse McCarroll V32	ABI3BP CHRM3 PPP1CA	2.79e-05	82	32	3	045e702e7cb208107e8529a35f0cbbcf75b20786
ToppCell	P07-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MYOF POMGNT2 ABI3BP	1.78e-04	153	32	3	5501095bcf73080872ae01128f21399f9cfc5dd1
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	RNF213 UTY DOCK9	1.88e-04	156	32	3	1545169694f686d28648a68b552c2ae606599d66
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	RNF213 FNTA MAP4K4	1.99e-04	159	32	3	6c0ef40f64d2e35eaae3d0002e3c1f22d1239736
ToppCell	Control-Myeloid-Monocytes,_Macrophages-Mast-cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AP1S3 CHRM3 ACSS1	1.99e-04	159	32	3	81782e9e370558d61af5e0c760ac9759d69fb725
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	RNF213 FNTA MAP4K4	1.99e-04	159	32	3	745a59c33b04620c5329bdd50e74a8e611f2dc55
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3C2B CHRM3 DOCK9	2.22e-04	165	32	3	a74751e0ec857aa974bec04ccc747c004a8f6e01
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3C2B CHRM3 DOCK9	2.38e-04	169	32	3	987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3C2B CHRM3 DOCK9	2.38e-04	169	32	3	c7fc3a8c44f07c557b60d469717b66e2f5863d38
ToppCell	facs-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AP1S3 CHRM3 SUV39H1	2.47e-04	171	32	3	f1fdc0ec3399ed6955976d02be7e5fc329a64276
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PIK3C2B CHRM3 DOCK9	2.51e-04	172	32	3	de9b11ab109d04937186c09772cec9105a935f95
ToppCell	390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	POMGNT2 AP1S3 NEDD4	2.55e-04	173	32	3	b9dee61973559e8c2fef3f2dafd43475b386befb
ToppCell	severe_COVID-19-HSPC\|severe_COVID-19 / disease group, cell group and cell class (v2)	PTPRD ABI3BP CHRM3	2.60e-04	174	32	3	6d35bacf073537b272ff821e604c899fb9ce6a7c
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PIK3C2B CHRM3 DOCK9	2.73e-04	177	32	3	5ff8dcfb030312126695d53a026d2e104a401b83
ToppCell	severe_COVID-19-HSPC\|World / disease group, cell group and cell class (v2)	PTPRD ABI3BP CHRM3	2.73e-04	177	32	3	289f6aed6f054b04b01659434d8c8b467d1bf5dd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3C2B CHRM3 DOCK9	2.78e-04	178	32	3	5f779a66aa42d1d8e8af17b4a08d5dcc733efd4c
ToppCell	Adult-Epithelial-club_cell-D122\|Adult / Lineage, Cell type, age group and donor	PTPRD UTY AGAP1	2.78e-04	178	32	3	35a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PIK3C2B CHRM3 DOCK9	2.78e-04	178	32	3	c227da59dc7beb73f84405bf13356bdeb59d9338
ToppCell	facs-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AP1S3 GUCY2C ACSS1	2.82e-04	179	32	3	b7a2429d07d7146b32b3552a5f2a2542105a71e0
ToppCell	COVID-19-Endothelial_cells-Capillary_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	CHRM3 DOCK9 NEDD4	2.91e-04	181	32	3	c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCell	droplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABI3BP PIK3C2B DOCK9	2.91e-04	181	32	3	136b0c60680068838d184d32aa99d7bea8718dbc
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NCAM2 PTPRD ABI3BP	2.91e-04	181	32	3	9ede19228ba5c0668a9c06c915510b95585216ef
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DBP ABI3BP PIK3C2B	2.91e-04	181	32	3	4ea02344e1996f264dd5e14f3b19c8782ce41699
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	WDFY3 PTPRD ABI3BP	2.96e-04	182	32	3	5e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCell	facs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NCAM2 CCIN DOCK9	2.96e-04	182	32	3	d22ab50b135482915687c70e6dad29bfe2bb2c68
ToppCell	Control-Endothelial-Endothelial-Activated_Alv_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RNF213 DOCK9 NEDD4	3.01e-04	183	32	3	e81c142770f44fd902b0631bc360c5b5339d4c75
ToppCell	COVID-19_Moderate-HSPC\|World / disease group, cell group and cell class	PTPRD CHRM3 NEDD4	3.06e-04	184	32	3	ccc93babe1fcdeb66b78e1d8414357877a7c45bd
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PIK3C2B CHRM3 DOCK9	3.06e-04	184	32	3	a809b0fa52df8a159f60f87eefcef61220af5e34
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-4\|TCGA-Thryoid / Sample_Type by Project: Shred V9	SMG5 DOCK9 CAPN2	3.06e-04	184	32	3	d9659d1e4465fec68f48a22edef443f354f6c7cf
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	NCAM2 PTPRD ABI3BP	3.11e-04	185	32	3	9f19f04fc4d97dfc2dd78cde77b515f1cb5d51ec
ToppCell	Brain_organoid-organoid_Kanton_Nature\|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.	JADE1 BAZ1A EPC1	3.11e-04	185	32	3	857c7ca8493e91ef1d0078ddafd6082020f9b169
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PIK3C2B DOCK9 NEDD4	3.11e-04	185	32	3	808d5e880069aff8866cd2c733b9fe568a37701f
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COPA MAP4K4 UTY	3.11e-04	185	32	3	eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NCAM2 PTPRD ABI3BP	3.11e-04	185	32	3	1ac6a32cc56d5d819649bdd99518e2ead0eead4c
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	PTPRD DOCK9 AGAP1	3.11e-04	185	32	3	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	COVID-19_Moderate-HSPC\|COVID-19_Moderate / disease group, cell group and cell class	PTPRD CHRM3 NEDD4	3.11e-04	185	32	3	cacc6ab5f26f6c803894567fb838ea06eaa7efe5
ToppCell	Myeloid-B_(Activated_Macrophage)\|World / shred on cell class and cell subclass (v4)	MYOF BAZ1A AGAP1	3.16e-04	186	32	3	33d731a7883d75e4e7db83b641cdb1e9a39938bf
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AP1S3 MAP4K4 GUCY2C	3.16e-04	186	32	3	1a1e5d85a5ad90afee234c12a9b54a5e93a8a2f2
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AP1S3 MAP4K4 GUCY2C	3.16e-04	186	32	3	f1366638edaecad5cad6367440f4c693513bed7e
ToppCell	Control-Endothelial-Endothelial-Artery\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PIK3C2B CHRM3 DOCK9	3.16e-04	186	32	3	2d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NCAM2 PTPRD ABI3BP	3.16e-04	186	32	3	4d68ee3d32f7ef884faf402ef92b31b0eb4656f1
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	NCAM2 PTPRD ABI3BP	3.21e-04	187	32	3	5258674d0346e5c51a4b965efcdc1790c970845d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	WDFY3 PTPRD AGAP1	3.21e-04	187	32	3	9d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PIK3C2B DOCK9 NEDD4	3.21e-04	187	32	3	dffa8447c2f3fdacf39a7258c6b4e81a25245041
ToppCell	Control-Endothelial_cells-Arterial_endothelial_cells\|Control / group, cell type (main and fine annotations)	ABI3BP PIK3C2B DOCK9	3.21e-04	187	32	3	81affaab3fe3e1daea45ada6445e906ddd33950e
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PIK3C2B CHRM3 DOCK9	3.26e-04	188	32	3	366a2d59b9c81d8a7659749f9c07efa46b49a39a
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MYOF JADE1 AP1S3	3.26e-04	188	32	3	eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MYOF AP1S3 CAPN2	3.26e-04	188	32	3	43a3a59f92ad93509d4166bd025aed0b1b39a008
ToppCell	3'_v3-blood-Lymphocytic_T_CD8-Trm/em_CD8\|blood / Manually curated celltypes from each tissue	RNF213 UTY PPP1CA	3.26e-04	188	32	3	21730497f95dc271e4cdfaaf1da8b9ac6eec2ded
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABI3BP CHRM3 DOCK9	3.26e-04	188	32	3	a37edd8f9e4a4e336b5acbb0407d3d275975cee8
ToppCell	PCW_13-14-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PIK3C2B CHRM3 DOCK9	3.26e-04	188	32	3	b66f1f08827dd6c48583d871f9f33ea41e48bfb2
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	MYOF CHRM3 AGAP1	3.26e-04	188	32	3	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NCAM2 PTPRD ABI3BP	3.31e-04	189	32	3	203c80030df08ae112f9ae4043709f455d87ce89
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOF BAZ1A AGAP1	3.31e-04	189	32	3	287e59104687fe1665232c52993889f0f2c97f17
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3C2B CHRM3 DOCK9	3.31e-04	189	32	3	6463890d8dbee4bc198f91628a5f784970de786a
ToppCell	Control-Endothelial-Endothelial-Alv_Gen_Intermediate\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTPRD DOCK9 NEDD4	3.31e-04	189	32	3	5d7ae1ead7f4fbaeec26f651833c9c2106e1e4d1
ToppCell	droplet-Lung-LUNG-1m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOF BAZ1A AGAP1	3.31e-04	189	32	3	6d24414ac6bd4f03f7a5ad3a6eba51d549a7b112
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYOF PTPRD ABI3BP	3.31e-04	189	32	3	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	10x5'v1-week_12-13-Mesenchymal_fibro-stroma-endosteal_fibroblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ABI3BP CCIN AGAP1	3.31e-04	189	32	3	473b01c9162b12b90a617c600238436177a0d18d
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PIK3C2B CHRM3 DOCK9	3.31e-04	189	32	3	c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCell	PND07-28-samps-Mesenchymal-Matrix_fibroblast\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	PTPRD ABI3BP NEDD4	3.31e-04	189	32	3	dc5164591dea45b420798b94dda211be03daa70c
ToppCell	3'_v3-blood-Lymphocytic_T_CD8\|blood / Manually curated celltypes from each tissue	RNF213 UTY PPP1CA	3.36e-04	190	32	3	5dca8654964c41580fa3b094579fe7cb296d406f
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PIK3C2B DOCK9 NEDD4	3.36e-04	190	32	3	474cbbab8f3b0a6881fa6c92edb78e43999f9ab0
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CHRM3 DOCK9 NEDD4	3.36e-04	190	32	3	0a351609a72fd638c84b2435782e312ee6a33aac
ToppCell	facs-Skin-Anagen-3m-Epithelial\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOF UTY CAPN2	3.36e-04	190	32	3	888ded899f0513d41bf655896d59ae8ef74e0978
ToppCell	LV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	NCAM2 PTPRD ABI3BP	3.36e-04	190	32	3	12992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCell	facs-Skin-Anagen-3m\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOF UTY CAPN2	3.36e-04	190	32	3	3466cebab16964e94da130d0673fa32e7d90b5ed
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PIK3C2B CHRM3 DOCK9	3.36e-04	190	32	3	7ba2be2630183df86de21689289a8620a4cd507e
Computational	Neighborhood of PTPRD	PTPRD MAP4K4 DOCK9	3.98e-04	58	27	3	GCM_PTPRD
Computational	Genes in the cancer module 119.	MYOF DBP PIK3C2B UTY	4.15e-04	143	27	4	MODULE_119
Disease	childhood onset asthma	PTPRD ABI3BP AP1S3 MAP4K4	3.99e-04	334	31	4	MONDO_0005405
Disease	joint hypermobility measurement	ABI3BP NEDD4	5.53e-04	33	31	2	EFO_0007905
Disease	Autoinflammatory disorder	COPA AP1S3	6.22e-04	35	31	2	C3860213
Disease	Moyamoya disease	RNF213 DOCK9	8.13e-04	40	31	2	MONDO_0016820
Disease	lip morphology measurement	MYOF POMGNT2 MAP4K4	1.02e-03	189	31	3	EFO_0007845
Disease	prostate carcinoma	RNF213 PTPRD PIK3C2B GUCY2C NEDD4	2.20e-03	891	31	5	EFO_0001663
Disease	white matter hyperintensity measurement	MINPP1 PTPRD CHRM3	3.86e-03	302	31	3	EFO_0005665
Disease	Ischemic stroke, coronary artery disease	RNF213 NCAM2	4.22e-03	92	31	2	EFO_0001645, HP_0002140
Disease	type 2 diabetes mellitus (implicated_via_orthology)	PPP1CA PPP1CC	5.45e-03	105	31	2	DOID:9352 (implicated_via_orthology)
Disease	endometrial carcinoma	NCAM2 PTPRD	6.29e-03	113	31	2	EFO_1001512

Protein segments in the cluster

Peptide	Gene	Start	Entry
IREVYEYWIKKRKNC	EPC1	171	Q9H2F5
VRLLLKYGDAWVKKY	ACSS1	391	Q9NUB1
EEKERWIRAKYEQKL	AGAP1	706	Q9UPQ3
LINWVYFRKEDREKY	CCIN	201	Q13939
YWRIYKETEKRTKEL	CHRM3	251	P20309
LREEKRKYVEYLKQW	BAZ1A	381	Q9NRL2
RKYVEYLKQWSKPRE	BAZ1A	386	Q9NRL2
KYRKDYELRQKKWSH	GUCY2C	456	P25092
DWKELKLVYKRYASL	AP1S3	51	Q96PC3
KDKLRVYYLSWLRNK	MAP4K4	986	O95819
YEAWKVRELKRIKRD	MFAP1	276	P55081
KNKKEYIYLVIQWRF	NEDD4	1146	P46934
NLKYLKVREVKYEVW	POMGNT2	511	Q8NAT1
LTDADKKRLWEKRYY	PIK3C2B	831	O00750
FYDECKRRYNIKLWK	PPP1CA	136	P62136
WKAERYELIADIYKL	DOCK9	1726	Q9BZ29
DDYKIKVWNYKLRRC	COPA	71	P53621
VWFKNYRVKQRKLDY	DUXB	61	A0A1W2PPF3
EEQKDEKYWSRRYKN	DBP	251	Q10586
WTKIQKYQKIYREID	CAPN2	601	P17655
KYLLEQLEKWTEYRI	PTPRD	671	P23468
YKLAVERYEWNKLKS	UTY	1196	O14607
RKAEELLWRKVYYEV	SMG5	76	Q9UPR3
KEKDTIRKEYWRYIG	FNTA	346	P49354
VVDFLYQYWKLKRKV	JADE1	446	Q6IE81
YKKIREQEYYLVKWR	SUV39H1	51	O43463
WTDLQYREKEVKRYL	RNF213	576	Q63HN8
YREKEVKRYLWQHLK	RNF213	581	Q63HN8
DERLAQYKKRYKDWE	WDFY3	2761	Q8IZQ1
KVLEYLNDLKQYWKR	MINPP1	311	Q9UNW1
YIVKYRSKDKEDQWL	NCAM2	626	O15394
FYDECKRRYNIKLWK	PPP1CC	136	P36873
YTIRYREKDKEKKWI	ABI3BP	156	Q7Z7G0
KKYYLRVIIWNTKDV	MYOF	1786	Q9NZM1