Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncytoskeletal protein binding

NPHS1 ABRA MYH4 BIN1 MYH13 SPTA1 CAPN1 RUSC1 FSD1 CCDC61 AP1AR TTBK1 INF2 AVIL KCNN2 RP1 MTCL1 IQGAP3 MAPK8IP2

1.91e-06109910019GO:0008092
GeneOntologyMolecularFunctionacetylgalactosaminyltransferase activity

GALNT14 B4GALNT4 GALNT11 GALNT4

2.75e-05351004GO:0008376
GeneOntologyMolecularFunctionpolypeptide N-acetylgalactosaminyltransferase activity

GALNT14 GALNT11 GALNT4

1.31e-04201003GO:0004653
GeneOntologyMolecularFunction3'-5' RNA helicase activity

YTHDC2 DHX9

3.68e-0461002GO:0034458
GeneOntologyMolecularFunctionactin binding

ABRA MYH4 BIN1 MYH13 SPTA1 RUSC1 INF2 AVIL IQGAP3

6.73e-044791009GO:0003779
GeneOntologyMolecularFunctioncarbohydrate binding

GALNT14 EGLN2 PFKL FBXO6 GALNT11 FAM3A GALNT4

9.48e-043101007GO:0030246
GeneOntologyMolecularFunctionactin filament binding

MYH4 BIN1 MYH13 SPTA1 AVIL IQGAP3

9.90e-042271006GO:0051015
GeneOntologyMolecularFunctioncalmodulin binding

MYH4 MYH13 DAPK1 EFCAB9 KCNN2 IQGAP3

1.06e-032301006GO:0005516
GeneOntologyMolecularFunctionlipid binding

BIN1 LCN12 SNX17 TRIP10 SYT10 TTPA PLA2G15 MICALL1 OSBPL3 AVIL AKR1B15 MCTP2 ALOX15B

1.29e-0398810013GO:0008289
GeneOntologyMolecularFunctionvitamin binding

EGLN2 TTPA FASN AKR1B15 PCCA

1.30e-031611005GO:0019842
GeneOntologyMolecularFunctioncalcium ion binding

CAPN12 TPO SPTA1 CAPN1 SYT10 EFCAB9 CDH20 GUCA1B PDP1 MCTP2 ALOX15B

1.31e-0374910011GO:0005509
GeneOntologyMolecularFunctionmedium-chain fatty acid-CoA ligase activity

ACSM1 AACS

1.33e-03111002GO:0031956
GeneOntologyBiologicalProcessprotein polymerization

NPHS1 BIN1 NCKAP1 SPTA1 CAPN1 TTBK1 INF2 AVIL RP1

3.31e-05334999GO:0051258
GeneOntologyBiologicalProcessactin filament polymerization

NPHS1 BIN1 NCKAP1 SPTA1 CAPN1 INF2 AVIL

3.67e-05190997GO:0030041
GeneOntologyBiologicalProcessshort-chain fatty acid metabolic process

ACSM1 PCCA PCK2

8.31e-0518993GO:0046459
GeneOntologyBiologicalProcessregulation of NMDA receptor activity

CAPN1 DAPK1 MAPK8IP2

8.31e-0518993GO:2000310
GeneOntologyBiologicalProcessactin polymerization or depolymerization

NPHS1 BIN1 NCKAP1 SPTA1 CAPN1 INF2 AVIL

9.79e-05222997GO:0008154
GeneOntologyBiologicalProcessregulation of actin filament polymerization

NPHS1 BIN1 NCKAP1 SPTA1 CAPN1 AVIL

1.07e-04156996GO:0030833
GeneOntologyBiologicalProcessregulation of protein polymerization

NPHS1 BIN1 NCKAP1 SPTA1 CAPN1 TTBK1 AVIL

1.25e-04231997GO:0032271
GeneOntologyCellularComponentactin cytoskeleton

ABRA MYH4 BIN1 MYH13 NCKAP1 SPTA1 DAPK1 DHX9 INF2 AVIL

4.37e-0457610010GO:0015629
GeneOntologyCellularComponentsupramolecular fiber

ABRA MYH4 BIN1 MYH13 NCKAP1 RUSC1 FSD1 TRIP10 TMEM232 INF2 AVIL KCNN2 RP1 MTCL1 DYNC1H1

4.72e-04117910015GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

ABRA MYH4 BIN1 MYH13 NCKAP1 RUSC1 FSD1 TRIP10 TMEM232 INF2 AVIL KCNN2 RP1 MTCL1 DYNC1H1

5.06e-04118710015GO:0099081
DomainGlycos_transf_2

GALNT14 GALNT11 GALNTL5 GALNT4

1.62e-0530964PF00535
DomainGlyco_trans_2-like

GALNT14 GALNT11 GALNTL5 GALNT4

1.62e-0530964IPR001173
DomainPpantetheine_attach_site

FASN ALDH1L2

7.82e-053962IPR006162
DomainSH3_1

BIN1 SPTA1 RUSC1 TRIP10 SH3RF3 MAPK8IP2

2.02e-04164966PF00018
Domain-

FASN ALDH1L2

2.59e-0459621.10.1200.10
DomainPHOSPHOPANTETHEINE

FASN ALDH1L2

2.59e-045962PS00012
DomainSPIN/Ssty

SPIN1 SPIN3

2.59e-045962IPR003671
DomainSpin-Ssty

SPIN1 SPIN3

2.59e-045962PF02513
DomainPP-binding

FASN ALDH1L2

2.59e-045962PF00550
DomainACP_DOMAIN

FASN ALDH1L2

2.59e-045962PS50075
DomainRicin_B_lectin

GALNT14 GALNT11 GALNT4

2.79e-0425963PF00652
DomainPP-bd_ACP

FASN ALDH1L2

3.87e-046962IPR009081
DomainRICIN

GALNT14 GALNT11 GALNT4

3.93e-0428963SM00458
DomainRICIN_B_LECTIN

GALNT14 GALNT11 GALNT4

3.93e-0428963PS50231
DomainRicin_B_lectin

GALNT14 GALNT11 GALNT4

4.83e-0430963IPR000772
DomainSH3_9

BIN1 RUSC1 SH3RF3 MAPK8IP2

6.99e-0478964PF14604
Domain-

GALNT14 B4GALNT4 GALNT11 GALNTL5

8.06e-04819643.90.550.10
DomainSH3

BIN1 SPTA1 RUSC1 TRIP10 SH3RF3 MAPK8IP2

8.71e-04216966SM00326
DomainSH3

BIN1 SPTA1 RUSC1 TRIP10 SH3RF3 MAPK8IP2

8.71e-04216966PS50002
DomainSH3_domain

BIN1 SPTA1 RUSC1 TRIP10 SH3RF3 MAPK8IP2

9.58e-04220966IPR001452
DomainNucleotide-diphossugar_trans

GALNT14 B4GALNT4 GALNT11 GALNTL5

1.10e-0388964IPR029044
Domaincalpain_III

CAPN12 CAPN1

1.67e-0312962SM00720
DomainC2_III

CAPN12 CAPN1

1.67e-0312962IPR033883
DomainCalpain_III

CAPN12 CAPN1

1.67e-0312962IPR022683
Domain-

ANKRD39 SOWAHD DAPK1 YTHDC2 NFKBIL1 ANKRD16

1.77e-032489661.25.40.20
DomainANK

ANKRD39 SOWAHD DAPK1 YTHDC2 NFKBIL1 ANKRD16

1.88e-03251966SM00248
DomainANK_REPEAT

ANKRD39 SOWAHD DAPK1 YTHDC2 NFKBIL1 ANKRD16

1.95e-03253966PS50088
DomainCalpain_III

CAPN12 CAPN1

1.97e-0313962PF01067
DomainCalpain_domain_III

CAPN12 CAPN1

1.97e-0313962IPR022682
DomainAnkyrin_rpt-contain_dom

ANKRD39 SOWAHD DAPK1 YTHDC2 NFKBIL1 ANKRD16

1.99e-03254966IPR020683
DomainANK_REP_REGION

ANKRD39 SOWAHD DAPK1 YTHDC2 NFKBIL1 ANKRD16

1.99e-03254966PS50297
DomainCalpain_cysteine_protease

CAPN12 CAPN1

2.29e-0314962IPR022684
DomainAnkyrin_rpt

ANKRD39 SOWAHD DAPK1 YTHDC2 NFKBIL1 ANKRD16

2.33e-03262966IPR002110
DomainPeptidase_C2

CAPN12 CAPN1

2.63e-0315962PF00648
DomainCysPc

CAPN12 CAPN1

2.63e-0315962SM00230
DomainPeptidase_C2_calpain_cat

CAPN12 CAPN1

2.63e-0315962IPR001300
DomainMyosin_N

MYH4 MYH13

2.63e-0315962PF02736
DomainCALPAIN_CAT

CAPN12 CAPN1

2.63e-0315962PS50203
DomainMyosin_N

MYH4 MYH13

2.63e-0315962IPR004009
DomainMethyltransf_11

EEF1AKMT2 METTL27

2.99e-0316962IPR013216
DomainMethyltransf_11

EEF1AKMT2 METTL27

2.99e-0316962PF08241
DomainDUF1605

YTHDC2 DHX9

3.38e-0317962IPR011709
DomainOB_NTP_bind

YTHDC2 DHX9

3.38e-0317962PF07717
DomainMyosin_tail_1

MYH4 MYH13

3.79e-0318962PF01576
DomainMyosin_tail

MYH4 MYH13

3.79e-0318962IPR002928
DomainHA2

YTHDC2 DHX9

3.79e-0318962SM00847
DomainHA2

YTHDC2 DHX9

3.79e-0318962PF04408
DomainHelicase-assoc_dom

YTHDC2 DHX9

3.79e-0318962IPR007502
DomainPP2C

PDP1 PHLPP1

4.22e-0319962PF00481
DomainMyosin-like_IQ_dom

MYH4 MYH13

4.22e-0319962IPR027401
Domain-

MYH4 MYH13

4.22e-03199624.10.270.10
DomainPP2Cc

PDP1 PHLPP1

4.68e-0320962SM00332
Domain-

PDP1 PHLPP1

4.68e-03209623.60.40.10
DomainPPM-type_phosphatase_dom

PDP1 PHLPP1

4.68e-0320962IPR001932
DomainPPM_2

PDP1 PHLPP1

4.68e-0320962PS51746
PathwayKEGG_O_GLYCAN_BIOSYNTHESIS

GALNT14 GALNT11 GALNTL5 GALNT4

1.73e-0530744M6929
Pubmed

O-glycosylation modulates integrin and FGF signalling by influencing the secretion of basement membrane components.

GALNT14 LAMA5 ITGA6 GALNT11 GALNT4

1.19e-0740102522643896
Pubmed

Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome.

GALNT14 GALNT11 GALNTL5 GALNT4

7.08e-0724102431882545
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

MYH4 NUP107 DHX9 FASN PRRC2C MROH7 IQGAP3

2.33e-06202102733005030
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

NUP107 NCKAP1 DENND4C DHX9 MICALL1 UBE2V1 OSBPL3 CD2BP2 NFKBIL1 IFT122 RPGR SH3RF3 IQGAP3 DYNC1H1 PCK2

7.18e-0613211021527173435
Pubmed

Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans.

CAPN1 PHLPP1

8.52e-062102227320912
Pubmed

Deleting both PHLPP1 and CANP1 rescues impairments in long-term potentiation and learning in both single knockout mice.

CAPN1 PHLPP1

8.52e-062102227421891
Pubmed

Combined activation of calpain and calcineurin during ligand-induced growth cone collapse.

RCAN1 CAPN1

8.52e-062102217826176
Pubmed

Keratinocyte-secreted laminin 5 can function as a transient receptor for human papillomaviruses by binding virions and transferring them to adjacent cells.

LAMA5 ITGA6

8.52e-062102216940506
Pubmed

Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice.

LAMA5 ITGA6

8.52e-06210228673141
Pubmed

DNA sequence and analysis of human chromosome 18.

ATP9B PHLPP1 MTCL1

1.62e-0517102316177791
Pubmed

Repression of rRNA transcription by PARIS contributes to Parkinson's disease.

NUP107 NCKAP1 PFKL DHX9 FASN PCCA DYNC1H1

1.62e-05272102725315684
Pubmed

The mucin-type glycosylating enzyme polypeptide N-acetylgalactosaminyltransferase 14 promotes the migration of ovarian cancer by modifying mucin 13.

GALNT14 GALNT4

2.55e-053102223708057
Pubmed

Localization of Lutheran, a novel laminin receptor, in normal, knockout, and transgenic mice suggests an interaction with laminin alpha5 in vivo.

LAMA5 ITGA6

2.55e-053102211507772
Pubmed

Raf-1 is a binding partner of DSCR1.

RCAN1 CAPN1

2.55e-053102215935327
Pubmed

Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans.

GALNT14 GALNT11 GALNT4

3.62e-0522102325107907
Pubmed

Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.

GALNT14 GALNT11 GALNT4

4.74e-0524102331740596
Pubmed

Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.

MYH4 MYH13

5.09e-054102210388558
Pubmed

Melanoma cells produce multiple laminin isoforms and strongly migrate on α5 laminin(s) via several integrin receptors.

LAMA5 ITGA6

5.09e-054102221195710
Pubmed

Integrin alpha6beta4-erbB2 complex inhibits haptotaxis by up-regulating E-cadherin cell-cell junctions in keratinocytes.

LAMA5 ITGA6

5.09e-054102215579904
Pubmed

Diverse effects of pathogenic mutations of Parkin that catalyze multiple monoubiquitylation in vitro.

UBE2G2 UBE2V1

5.09e-054102216339143
Pubmed

Src-mediated tyrosine phosphorylation of NR2 subunits of N-methyl-D-aspartate receptors protects from calpain-mediated truncation of their C-terminal domains.

CAPN1 GRIN2A

5.09e-054102210846184
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

ENPP6 BIN1 NCKAP1 SPTA1 DAPK1 YTHDC2 GRIN2A PFKL DHX9 FASN INF2 PRRC2C DYNC1H1 MAPK8IP2

7.54e-0514311021437142655
Pubmed

Laminin-5-integrin interaction signals through PI 3-kinase and Rac1b to promote assembly of adherens junctions in HT-29 cells.

LAMA5 ITGA6

8.47e-055102216339173
Pubmed

Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesis.

LAMA5 ITGA6

8.47e-055102216581764
Pubmed

Structure and function of hemidesmosomes: more than simple adhesion complexes.

LAMA5 ITGA6

8.47e-055102210201522
Pubmed

STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.

KIAA0232 MTCL1 DYNC1H1

1.04e-0431102328089446
Pubmed

O-GlcNAcylation of SPOP promotes carcinogenesis in hepatocellular carcinoma.

PFKL DHX9 FASN INF2 DYNC1H1 PCK2

1.07e-04254102636604567
Pubmed

Splicing Regulator p54nrb /Non-POU Domain-Containing Octamer-Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box-Dependent Interacting Protein 1 in Hepatocellular Carcinoma.

BIN1 DHX9 PCK2

1.14e-0432102331815296
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

BIN1 NCKAP1 DAPK1 GRIN2A PLA2G15 UBE2V1 OSBPL3 PRRC2C MTCL1 DYNC1H1 MAPK8IP2

1.25e-049631021128671696
Pubmed

Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

CAPN1 TTBK1

1.27e-046102219118186
Pubmed

Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.

MYH4 MYH13

1.27e-046102210077619
Pubmed

Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival.

LAMA5 ITGA6

1.27e-046102223847204
Pubmed

alpha3beta1 and alpha6beta4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development.

LAMA5 ITGA6

1.27e-046102210934043
Pubmed

Laminin alpha1 globular domains 4-5 induce fetal development but are not vital for embryonic basement membrane assembly.

LAMA5 ITGA6

1.27e-046102215668394
Pubmed

A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1.

SPIN1 SPIN3

1.27e-046102229061846
Pubmed

Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins.

LAMA5 ITGA6

1.27e-046102210671376
Pubmed

Galnt1 is required for normal heart valve development and cardiac function.

GALNT14 GALNT11 GALNT4

1.63e-0436102325615642
Pubmed

Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly.

LAMA5 DHX9 FASN DYNC1H1

1.67e-0493102438245532
Pubmed

A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.

MYH4 MYH13

1.77e-047102235210422
Pubmed

Localization of extracellular matrix receptors in ICGN mice, a strain of mice with hereditary nephrotic syndrome.

ITGA6 RP1

1.77e-047102211767049
Pubmed

Autoregulation of Parkin activity through its ubiquitin-like domain.

UBE2G2 UBE2V1

1.77e-047102221694720
Pubmed

alpha3beta1 Integrin is required for normal development of the epidermal basement membrane.

LAMA5 ITGA6

1.77e-04710229151677
Pubmed

Abscence of laminin alpha1 chain in the skeletal muscle of dystrophic dy/dy mice.

LAMA5 ITGA6

1.77e-04710229390664
Pubmed

The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin.

LAMA5 ITGA6

1.77e-047102215302884
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

ENPP6 NPHS1 MYH13 NCKAP1 CAPN1 ACSM1 LAMA5 PFKL TRIP10 FASN DYNC1H1

1.98e-0410161021119056867
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

NCKAP1 CAPN1 YTHDC2 TRIP10 DHX9 FASN IQGAP3 DYNC1H1 PCK2

2.33e-04704102929955894
Pubmed

Neuromuscular junction immaturity and muscle atrophy are hallmarks of the ColQ-deficient mouse, a model of congenital myasthenic syndrome with acetylcholinesterase deficiency.

MYH4 CHRNE

2.36e-048102226993635
Pubmed

FBXL6 degrades phosphorylated p53 to promote tumor growth.

DHX9 FASN

2.36e-048102233568778
Pubmed

The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis.

RP1 RPGR

2.36e-048102212651948
Pubmed

Acetoacetyl-CoA synthetase is essential for normal neuronal development.

FASN AACS

2.36e-048102223000407
Pubmed

Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.

SPTA1 PFKL DHX9 FASN DYNC1H1

2.50e-04190102515161933
Pubmed

The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.

PFKL DENND4C INF2 PRRC2C DYNC1H1 PCK2

2.54e-04298102630737378
Pubmed

An approach based on a genome-wide association study reveals candidate loci for narcolepsy.

DAPK1 GRIN2A PHLPP1 DYNC1H1 ALOX15B

2.69e-04193102520677014
Pubmed

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems.

CAPN1 GRIN2A

3.03e-049102217526495
Pubmed

Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality.

LAMA5 ITGA6

3.03e-049102230456378
Pubmed

The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer.

MYH4 UBE2G2

3.03e-049102236749630
Pubmed

Ataxin-3 promotes genome integrity by stabilizing Chk1.

FBXO6 DYNC1H1

3.03e-049102228180282
Pubmed

Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains.

BIN1 ITGA6

3.03e-049102210094488
Pubmed

SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation.

SH3RF3 MAPK8IP2

3.03e-049102232427938
Pubmed

Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly.

UBE2V1 PCCA

3.77e-0410102218678647
Pubmed

Integrin alpha6beta1-laminin interactions regulate early myotome formation in the mouse embryo.

LAMA5 ITGA6

3.77e-0410102216554364
Pubmed

Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro.

LAMA5 ITGA6

3.77e-0410102218590826
Pubmed

Trophoblast-specific expression and function of the integrin alpha 7 subunit in the peri-implantation mouse embryo.

LAMA5 ITGA6

3.77e-0410102211784026
Pubmed

LINC00152 Promotes Tumor Progression and Predicts Poor Prognosis by Stabilizing BCL6 From Degradation in the Epithelial Ovarian Cancer.

DHX9 FASN

3.77e-0410102233282727
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

B4GALNT4 LAMA5 MICALL1 FASN INF2 CD2BP2 TMEM132A METTL27 IQGAP3 DYNC1H1 ANKRD16

4.04e-0411051021135748872
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

NMNAT2 KIAA0232 CAPN1 ATP9B PFKL INF2 GALNT11 SPIN1 KCNN2 IFT122 PCCA MCTP2 SH3RF3

4.17e-0414891021328611215
Pubmed

The TIP60 Complex Is a Conserved Coactivator of HIF1A.

PFKL FASN PDP1 IQGAP3

4.41e-04120102427320910
Pubmed

BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.

NCKAP1 YTHDC2 DENND4C FASN PRRC2C

4.51e-04216102531519766
Pubmed

Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin.

NPHS1 LAMA5

4.60e-0411102211435469
Pubmed

Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shape.

LAMA5 ITGA6

4.60e-0411102216365040
Pubmed

Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival.

LAMA5 ITGA6

4.60e-041110228707838
Pubmed

The histone code reader Spin1 controls skeletal muscle development.

MYH4 SPIN1

4.60e-0411102229168801
Pubmed

SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium.

RP1 RPGR

4.60e-0411102229899041
Pubmed

Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers.

MYH4 RCAN1

4.60e-0411102216024798
Pubmed

Network organization of the huntingtin proteomic interactome in mammalian brain.

BIN1 NCKAP1 SPTA1 GRIN2A PFKL DHX9 FASN DYNC1H1

4.98e-04621102822794259
Pubmed

Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis.

LAMA5 ITGA6

5.51e-0412102211381080
Pubmed

Alpha9 and beta8 integrin expression correlates with the merger of the developing mouse eyelids.

LAMA5 ITGA6

5.51e-0412102210090148
Pubmed

Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse.

LAMA5 ITGA6

5.51e-0412102210433923
Pubmed

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

YTHDC2 DENND4C UBE2G2 DYNC1H1 MAPK8IP2

6.23e-04232102525515538
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

SPTA1 CAPN1 DAPK1 DHX9 FASN UBE2V1 PCCA IQGAP3 DYNC1H1

6.25e-04807102930575818
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

MYH4 MYH13 LAMA5 PFKL FASN PRRC2C IQGAP3 DYNC1H1

6.50e-04647102826618866
Pubmed

Insulin receptor substrate-4 interacts with ubiquitin-specific protease 18 to activate the Jak/STAT signaling pathway.

DHX9 FASN

6.50e-0413102229285303
Pubmed

The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability.

UBE2G2 UBE2V1

6.50e-0413102220940148
Pubmed

The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut.

LAMA5 ITGA6

6.50e-0413102236350252
Pubmed

EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells.

BIN1 MICALL1

6.50e-0413102226833786
Pubmed

Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.

LAMA5 ITGA6

6.50e-041310229670011
Pubmed

ECM-integrin signalling instructs cellular position sensing to pattern the early mouse embryo.

LAMA5 ITGA6

6.50e-0413102234908109
Pubmed

Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways.

NCKAP1 GRIN2A

7.57e-0414102215749123
Pubmed

Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice.

MYH4 CHRNE

7.57e-0414102238327785
Pubmed

Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome.

LAMA5 ITGA6

7.57e-0414102219783738
Pubmed

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

NUP107 LAMA5 YTHDC2 DHX9 PDZRN3

8.71e-04250102533536335
Pubmed

Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival.

RP1 RPGR

8.72e-0415102221148103
Pubmed

Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.

NUP107 DHX9 FASN DYNC1H1

8.75e-04144102435681168
Pubmed

Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex.

PFKL DHX9 DYNC1H1

8.96e-0464102322865885
Pubmed

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

DENND4C FASN PRRC2C PHLPP1 DYNC1H1

9.68e-04256102533397691
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

NCKAP1 KIAA0232 FSD1 DENND4C MICALL1 OSBPL3 PRRC2C MTCL1 SH3RF3

9.87e-04861102936931259
Pubmed

Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling.

LAMA5 ITGA6

9.95e-0416102217601529
Pubmed

Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation.

LAMA5 ITGA6

9.95e-0416102221067603
Pubmed

TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease.

MYH13 DENND4C SPIN1

1.02e-0367102334644545
Pubmed

New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.

UBE2G2 UBE2V1

1.13e-0317102226489670
InteractionLRRC31 interactions

MYH4 NUP107 TRIP10 DHX9 FASN PRRC2C MROH7 IQGAP3

7.75e-06205998int:LRRC31
CytobandEnsembl 112 genes in cytogenetic band chr5q22

YTHDC2 TMEM232 KCNN2

3.16e-04591023chr5q22
Cytoband18q21.33

CDH20 PHLPP1

5.75e-0416102218q21.33
GeneFamilyPolypeptide N-acetylgalactosaminyltransferases

GALNT14 GALNT11 GALNTL5 GALNT4

7.98e-0720674433
GeneFamilyTudor domain containing|Spindlin family

SPIN1 SPIN3

1.34e-0456721089
GeneFamilyEF-hand domain containing

CAPN12 SPTA1 CAPN1 EFCAB9 GUCA1B

1.31e-03219675863
GeneFamilyC2 domain containing|Calpains

CAPN12 CAPN1

1.38e-0315672975
GeneFamilyMyosin heavy chains

MYH4 MYH13

1.38e-03156721098
GeneFamilyProtein phosphatases, Mg2+/Mn2+ dependent

PDP1 PHLPP1

1.77e-0317672701
GeneFamilyGuanylate cyclase receptors|DENN/MADD domain containing

NPR2 DENND4C

3.84e-0325672504
GeneFamilyAcyl-CoA synthetase family

ACSM1 AACS

4.15e-032667240
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GALNT14 MYH4 DAPK1 SYT10 MCTP2 PDZRN3

3.94e-0618210265e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DAPK1 GRIN2A PRDM8 CDH20 PDP1 PDZRN3

5.04e-0619010261bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DAPK1 GRIN2A PRDM8 CDH20 PDP1 PDZRN3

5.85e-061951026787e95fb59c40bba784544b662fac37606ae1427
DrugClorgyline hydrochloride [17780-75-5]; Down 200; 13uM; MCF7; HT_HG-U133A

NPR2 YTHDC2 AAGAB MICALL1 GALNT11 PDP1 TMEM132A ZNF79

2.47e-0619610085005_DN
DiseaseCluttering

GRIN2A TTPA

3.40e-0531002C0009090
DiseaseDyslalia

GRIN2A TTPA

3.40e-0531002C3495145
DiseaseAprosodia

GRIN2A TTPA

3.40e-0531002C0233726
DiseaseRhinolalia

GRIN2A TTPA

3.40e-0531002C0751513
DiseaseDysglossia

GRIN2A TTPA

3.40e-0531002C0751512
DiseaseVerbal Fluency Disorders

GRIN2A TTPA

3.40e-0531002C0751514
Diseaseplatelet component distribution width

CAPN12 MYH13 KIAA0232 SPTA1 LAMA5 C4orf54 CHRNE MICALL1 PRRC2C EEF1AKMT2 SPIN3

5.13e-0575510011EFO_0007984
Diseasesusceptibility to hepatitis B infection measurement

YTHDC2 GRIN2A KCNN2 SPIN3

6.75e-05641004EFO_0008405
DiseaseSpeech Disorders

GRIN2A TTPA

6.79e-0541002C0037822
Disease2-hydroxydecanoate measurement

GALNT14 GALNTL5

1.13e-0451002EFO_0800347
DiseaseNEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE

NPHS1 NUP107 INF2

1.43e-04301003C1868672
Diseaseheart septal defect

YTHDC2 KCNN2

1.69e-0461002MONDO_0002078
DiseaseHydrocephalus

NMNAT2 IFT122

4.03e-0491002C0020255
DiseaseRetinitis Pigmentosa

TTPA GUCA1B RP1 RPGR

4.40e-041041004C0035334
Diseasetyrosine measurement

NPR2 SNX17 ZNF19 TTBK1

4.40e-041041004EFO_0005058
Diseaseurinary 6‑hydroxymelatonin sulfate to creatinine ratio

GALNT14 GALNTL5

5.03e-04101002EFO_0021488
Diseasedilated cardiomyopathy 1S (implicated_via_orthology)

MYH4 MYH13

5.03e-04101002DOID:0110454 (implicated_via_orthology)
Diseaseautosomal dominant hyaline body myopathy (implicated_via_orthology)

MYH4 MYH13

5.03e-04101002DOID:0111269 (implicated_via_orthology)
Diseasecongenital myopathy 6 (implicated_via_orthology)

MYH4 MYH13

5.03e-04101002DOID:0080719 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2B3 (implicated_via_orthology)

MYH4 MYH13

5.03e-04101002DOID:0111602 (implicated_via_orthology)
Diseaseinclusion body myositis (implicated_via_orthology)

MYH4 MYH13

5.03e-04101002DOID:3429 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2A (implicated_via_orthology)

MYH4 MYH13

5.03e-04101002DOID:0111605 (implicated_via_orthology)
Diseasefamilial hypertrophic cardiomyopathy (implicated_via_orthology)

MYH4 MYH13

5.03e-04101002DOID:0080326 (implicated_via_orthology)
Diseasedistal arthrogryposis type 1 (implicated_via_orthology)

MYH4 MYH13

5.03e-04101002DOID:0111596 (implicated_via_orthology)
DiseaseX-18913 measurement

GALNT14 GALNTL5

6.13e-04111002EFO_0800795
DiseaseCardiomyopathy, Familial Idiopathic

ABRA FASN PCCA

6.59e-04501003C1449563
Diseasedistal myopathy (implicated_via_orthology)

MYH4 MYH13

7.34e-04121002DOID:11720 (implicated_via_orthology)
Diseasemyotonia congenita (implicated_via_orthology)

MYH4 MYH13

7.34e-04121002DOID:2106 (implicated_via_orthology)
Diseaserestrictive cardiomyopathy (implicated_via_orthology)

MYH4 MYH13

8.66e-04131002DOID:397 (implicated_via_orthology)
DiseaseFamilial idiopathic steroid-resistant nephrotic syndrome

NPHS1 INF2

8.66e-04131002cv:C4273714
Diseasedistal arthrogryposis (implicated_via_orthology)

MYH4 MYH13

1.16e-03151002DOID:0050646 (implicated_via_orthology)
Diseasechronic kidney disease

ETFDH GRIN2A PRDM8 MOB3C PDZRN3

1.25e-032351005EFO_0003884
Diseasehippocampal tail volume

ENPP6 EEF1AKMT2

1.87e-03191002EFO_0009398
DiseaseRetinitis pigmentosa

GUCA1B RP1 RPGR

2.06e-03741003cv:C0035334
Diseasemaximal midexpiratory flow rate

GALNT14 GALNTL5

2.08e-03201002EFO_0004313
Diseaseurinary microalbumin measurement

YTHDC2 KCNN2

2.08e-03201002EFO_0010967
Diseaseuridine diphosphate measurement

YTHDC2 KCNN2

2.08e-03201002EFO_0010545
Diseasefetal hemoglobin measurement

YTHDC2 KCNN2

2.29e-03211002EFO_0004576
Diseaseepilepsy (implicated_via_orthology)

ITGA6 GRIN2A DHX9 DYNC1H1

2.33e-031631004DOID:1826 (implicated_via_orthology)
Diseasecardioembolic stroke

PRDM8 TTBK1 GORAB KCNN2

2.71e-031701004EFO_1001976
DiseaseRenal glomerular disease

NPHS1 INF2

2.75e-03231002C0268731
DiseaseGlomerulopathy Assessment

NPHS1 INF2

2.75e-03231002C4521256
Diseasesudden cardiac arrest

YTHDC2 GRIN2A KCNN2

2.85e-03831003EFO_0004278
Diseasecognitive function measurement

GALNT14 NMNAT2 YTHDC2 GRIN2A PLA2G15 ZNF19 TMEM232 PRRC2C KCNN2 GALNTL5 PHLPP1 SH3RF3

3.35e-03143410012EFO_0008354
Diseaseleft ventricular structural measurement

ABRA TMEM232 PDZRN3

3.36e-03881003EFO_0008205

Protein segments in the cluster

PeptideGeneStartEntry
WADEEDEVMVYGGVR

DAPK1

1116

P53355
QERMVDDGNGKVEVW

AVIL

386

O75366
RMTADQWRGEFDAGF

CCDC61

36

Q9Y6R9
LAEAWGMDIEATNRD

ANKRD16

56

Q6P6B7
ARNLGMAVEAWNEEG

AACS

461

Q86V21
DAFENGEWGRMNARE

ALDH1L2

491

Q3SY69
NDRETDFVLWAMGDL

NPR2

386

P20594
NGLEWENDFVSAEMD

AP1AR

256

Q63HQ0
LEEMDFERGIWSAAL

ANKRD39

26

Q53RE8
ERDQLRVKMEDGEFW

CAPN1

321

P07384
EDMFAWQIDFNGGDR

FBXO6

96

Q9NRD1
GEEVSDWVRMGNALD

CHRNE

441

Q04844
MAQGWAGFSEEELRR

GORAB

1

Q5T7V8
LEDQGGWELMEQVES

MROH7

926

Q68CQ1
GGDWSFIDCEMEEVD

RCAN1

46

P53805
QLDEGWMDDDRNDFL

PDZRN3

506

Q9UPQ7
DIGFEDGWLMRQDTE

PLA2G15

301

Q8NCC3
DGWLMRQDTEGLVEA

PLA2G15

306

Q8NCC3
WRQGKQMEEEGEEFT

MTCL1

1051

Q9Y4B5
LLFVDGGWMVDVRED

NUP107

821

P57740
GMFNWERLGEDEEDQ

NPHS1

771

O60500
WRELAMEALEGLDFE

IFT122

646

Q9HBG6
DRMGILDIEVWGKDN

MCTP2

411

Q6DN12
SDDGRFEVWNAMTRG

LCN12

71

Q6JVE5
REIQLFMVDNGADDW

KCNN2

191

Q9H2S1
LRVDDLSVEWDAMGG

FSD1

281

Q9BTV5
DWLEEECGNMAREGL

ATP9B

671

O43861
AFEDGGIDSVMEWEV

MFI

216

Q8NCR3
EEDDFWFRGFNMRTG

MAPK8IP2

636

Q13387
IVFDMLDWNAVGEID

EFCAB9

66

A8MZ26
VGDDIAWMRFDSEGR

PCK2

326

Q16822
DGMELQGERAIWTDS

KIAA0232

556

Q92628
EDGWENFMCERLGET

PFKL

236

P17858
GMNLEAWRETFPQDD

TPO

726

P07202
GMDIWGGENLEISFR

GALNT11

346

Q8NCW6
GGLNEGREDDMLVDW

MICALL1

711

Q8N3F8
LRIEDDMDGGDWSFC

ITGA6

161

P23229
EFVDMEGWVLLSTDR

LAMA5

1646

O15230
GELEDEWQEVMGRFE

NFKBIL1

171

Q9UBC1
GKGMRIAWDDEETRD

PCCA

226

P05165
DSRAMLGVQEEDGSW

PDP1

291

Q9P0J1
RLEGSDGGWMVQFLE

INF2

56

Q27J81
LRQERGMGEDFLSWN

IQGAP3

491

Q86VI3
EDGEVFDFRGMRLDW

NCKAP1

476

Q9Y2A7
EATLDRLEQAGMWEG

METTL27

181

Q8N6F8
DMDIWGGENFEISFR

GALNT14

301

Q96FL9
ELIEARAFDMWAGDV

FAM3A

116

P98173
AESRGDGLVDVMWEY

CD2BP2

271

O95400
LWMLDHQEDGGEALR

FCSK

506

Q8N0W3
TAFEEALGQLVWMDE

EEF1AKMT4-ECE2

586

P0DPD8
RWEGVNMERFAEEAD

ETFDH

56

Q16134
KEDGEFWMELRDFLL

CAPN12

316

Q6ZSI9
WETEEDDMTEGDLGY

CCDC125

16

Q86Z20
GEEDTEAFDIAAMWN

CDH20

671

Q9HBT6
MEVWGGENLELSFRV

GALNT4

331

Q8N4A0
GEIWFGEESMNRLIR

EEF1AKMT2

56

Q5JPI9
DKDMDFWGRENLELS

GALNTL5

326

Q7Z4T8
LVYDEEIMAGWTADD

DENND4C

1501

Q5VZ89
WVDGESELEFRRLGM

HEPN1

11

Q6WQI6
IDNIEGEWGAFNDIM

DYNC1H1

1211

Q14204
WARQENQEAEREGGM

EGLN2

136

Q96KS0
LVADEGWFITENREM

ENPP6

321

Q6UWR7
EEGFWRMFGEALEDL

GRIP2

866

Q9C0E4
EFWDNLIGGVDMVTD

FASN

21

P49327
LIGGVDMVTDDDRRW

FASN

26

P49327
EEQDEGWLMGVKESD

BIN1

556

O00499
DMDFDVGLASRWDFE

C4orf54

381

D6RIA3
NSWVEEAGMDEGAGR

C2CD4A

66

Q8NCU7
VFQAWDDARMGGEEA

DHX9

921

Q08211
LMDWIEGLINDEEVF

MOB3C

121

Q70IA8
RQDSWEVVEGLRGEM

OSBPL3

31

Q9H4L5
CMFEGENLFIWEEED

RP1

2126

P56715
DGMQIWGAVERFVSE

ALOX15B

476

O15296
TEDGRLFMWGDNSEG

RPGR

156

Q92834
TVDEDWLRCGRDGME

RUSC1

876

Q9BVN2
VAGEEDIRWVCEDMG

TMEM132A

991

Q24JP5
MEDTGIQRGIWDGDA

PRDM8

1

Q9NQV8
MGQEFSWEEAEAAGE

GUCA1B

1

Q9UMX6
LDAEADEGWAGAQME

PRRC2C

311

Q9Y520
KEGIEWEFIDFGMDL

MYH4

506

Q9Y623
LRELSGAEEWEMESG

SOWAHD

236

A6NJG2
DFEGEMLWQGRDDHV

ABRA

361

Q8N0Z2
GTFLDAWEAMEELVD

AKR1B15

136

C9JRZ8
WMAIGGDRDEIEGLS

AAGAB

296

Q6PD74
RVGGMNTEEFRDQWG

B4GALNT4

976

Q76KP1
GDEVKWSFREMGDLT

ACSM1

81

Q08AH1
DLSLMEEDKGDGWTR

TRIP10

566

Q15642
QSWDFGLDEILMEEG

C12orf40

441

Q86WS4
WDSAYDDDVMENRVG

SNX17

206

Q15036
SMKERGIAENEAFDW

TTBK1

296

Q5TCY1
LERGDMAWGLEAQDD

ZNF19

66

P17023
RRVDENWAEGMLGDK

SH3RF3

291

Q8TEJ3
WELQGDEEQDGLRNM

TMEM232

446

C9JQI7
FETEDGSKDEWRGMV

SPIN1

141

Q9Y657
IFETEEGSKNEWRGM

SPIN3

136

Q5JUX0
GLEDDEDMTLTRWTG

UBE2V1

36

Q13404
EGIEWEFIDFGMDLA

MYH13

506

Q9UKX3
WMSRQEAFLENEDLG

SPTA1

491

P02549
GGEEFSMEDICQEWT

TTPA

246

P49638
LDAEGLGRDHWNEML

SYT10

471

Q6XYQ8
IDAMDTWEDLTELGY

YTHDC2

816

Q9H6S0
GFGELWRVQEEGMDS

PHLPP1

501

O60346
EQREGAWMLEGEDLR

ZNF79

91

Q15937
EENFFEWEALIMGPE

UBE2G2

31

P60604
QFVGDGEMEELETLW

GRIN2A

781

Q12879
GLWNEADMEVIVGDF

NMNAT2

211

Q9BZQ4