Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	6-phosphofructokinase activity	PFKL PFKP	1.84e-05	3	50	2	GO:0003872
GeneOntologyMolecularFunction	fructose-6-phosphate binding	PFKL PFKP	6.12e-05	5	50	2	GO:0070095
GeneOntologyMolecularFunction	phosphofructokinase activity	PFKL PFKP	1.28e-04	7	50	2	GO:0008443
GeneOntologyMolecularFunction	calcium ion binding	JAG2 VLDLR FBN1 HMCN2 PLCH1 VWCE ADGRL3 NOTCH4	5.02e-04	749	50	8	GO:0005509
GeneOntologyMolecularFunction	apolipoprotein binding	VLDLR PLG	1.13e-03	20	50	2	GO:0034185
GeneOntologyMolecularFunction	extracellular matrix structural constituent	FBN1 HMCN2 SSPOP MUC5AC	1.25e-03	188	50	4	GO:0005201
GeneOntologyMolecularFunction	RNA cap binding	EIF3D CYFIP2	1.25e-03	21	50	2	GO:0000339
GeneOntologyMolecularFunction	AMP binding	PFKL PFKP	1.25e-03	21	50	2	GO:0016208
GeneOntologyMolecularFunction	carbohydrate kinase activity	PFKL PFKP	1.25e-03	21	50	2	GO:0019200
GeneOntologyMolecularFunction	Notch binding	JAG2 NOTCH4	2.07e-03	27	50	2	GO:0005112
GeneOntologyCellularComponent	6-phosphofructokinase complex	PFKL PFKP	1.68e-05	3	50	2	GO:0005945
Domain	EGF_CA	JAG2 VLDLR FBN1 HMCN2 VWCE NOTCH4	8.39e-08	86	48	6	PF07645
Domain	VWC_out	JAG2 VWCE SSPOP MUC5AC	1.45e-07	19	48	4	SM00215
Domain	EGF_Ca-bd_CS	JAG2 VLDLR FBN1 HMCN2 VWCE NOTCH4	1.73e-07	97	48	6	IPR018097
Domain	EGF_CA	JAG2 VLDLR FBN1 HMCN2 VWCE NOTCH4	1.95e-07	99	48	6	PS01187
Domain	ASX_HYDROXYL	JAG2 VLDLR FBN1 HMCN2 VWCE NOTCH4	2.07e-07	100	48	6	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	JAG2 VLDLR FBN1 HMCN2 VWCE NOTCH4	2.93e-07	106	48	6	IPR000152
Domain	EGF_CA	JAG2 VLDLR FBN1 HMCN2 VWCE NOTCH4	6.73e-07	122	48	6	SM00179
Domain	EGF-like_Ca-bd_dom	JAG2 VLDLR FBN1 HMCN2 VWCE NOTCH4	7.41e-07	124	48	6	IPR001881
Domain	VWFC_1	JAG2 VWCE SSPOP MUC5AC	2.13e-06	36	48	4	PS01208
Domain	EGF_3	JAG2 VLDLR FBN1 HMCN2 VWCE SSPOP NOTCH4	2.17e-06	235	48	7	PS50026
Domain	VWC	JAG2 VWCE SSPOP MUC5AC	2.66e-06	38	48	4	SM00214
Domain	VWFC_2	JAG2 VWCE SSPOP MUC5AC	2.66e-06	38	48	4	PS50184
Domain	Growth_fac_rcpt_	JAG2 VLDLR FBN1 HMCN2 VWCE NOTCH4	2.83e-06	156	48	6	IPR009030
Domain	EGF_1	JAG2 VLDLR FBN1 HMCN2 VWCE SSPOP NOTCH4	3.72e-06	255	48	7	PS00022
Domain	VWF_dom	JAG2 VWCE SSPOP MUC5AC	4.00e-06	42	48	4	IPR001007
Domain	EGF_2	JAG2 VLDLR FBN1 HMCN2 VWCE SSPOP NOTCH4	4.79e-06	265	48	7	PS01186
Domain	DUF4203	TMEM198 TM7SF3	6.47e-06	2	48	2	PF13886
Domain	DUF4203	TMEM198 TM7SF3	6.47e-06	2	48	2	IPR025256
Domain	PHOSPHOFRUCTOKINASE	PFKL PFKP	1.94e-05	3	48	2	PS00433
Domain	6-Pfructokinase_euk	PFKL PFKP	1.94e-05	3	48	2	IPR009161
Domain	Phosphofructokinase_CS	PFKL PFKP	1.94e-05	3	48	2	IPR015912
Domain	PFK	PFKL PFKP	1.94e-05	3	48	2	PF00365
Domain	ATP_PFK	PFKL PFKP	1.94e-05	3	48	2	IPR022953
Domain	Phosphofructokinase_dom	PFKL PFKP	1.94e-05	3	48	2	IPR000023
Domain	EGF-like_dom	JAG2 VLDLR FBN1 HMCN2 VWCE NOTCH4	4.06e-05	249	48	6	IPR000742
Domain	EGF-like_CS	JAG2 VLDLR FBN1 HMCN2 VWCE NOTCH4	5.28e-05	261	48	6	IPR013032
Domain	LDLR_class-A_CS	VLDLR TMPRSS15 SSPOP	1.47e-04	40	48	3	IPR023415
Domain	Ldl_recept_a	VLDLR TMPRSS15 SSPOP	2.10e-04	45	48	3	PF00057
Domain	-	VLDLR TMPRSS15 SSPOP	2.24e-04	46	48	3	4.10.400.10
Domain	LDLRA_1	VLDLR TMPRSS15 SSPOP	2.54e-04	48	48	3	PS01209
Domain	CUB	TMPRSS15 SEZ6L SEZ6	2.70e-04	49	48	3	PF00431
Domain	LDLRA_2	VLDLR TMPRSS15 SSPOP	2.70e-04	49	48	3	PS50068
Domain	LDrepeatLR_classA_rpt	VLDLR TMPRSS15 SSPOP	2.70e-04	49	48	3	IPR002172
Domain	LDLa	VLDLR TMPRSS15 SSPOP	2.70e-04	49	48	3	SM00192
Domain	CUB	TMPRSS15 SEZ6L SEZ6	2.87e-04	50	48	3	SM00042
Domain	-	TMPRSS15 SEZ6L SEZ6	3.22e-04	52	48	3	2.60.120.290
Domain	Sushi	CD55 SEZ6L SEZ6	3.22e-04	52	48	3	PF00084
Domain	EGF	JAG2 VLDLR FBN1 VWCE NOTCH4	3.33e-04	235	48	5	SM00181
Domain	CUB	TMPRSS15 SEZ6L SEZ6	3.41e-04	53	48	3	PS01180
Domain	GAIN_dom_N	ADGRB1 ADGRL3	3.51e-04	11	48	2	IPR032471
Domain	GAIN	ADGRB1 ADGRL3	3.51e-04	11	48	2	PF16489
Domain	CCP	CD55 SEZ6L SEZ6	3.60e-04	54	48	3	SM00032
Domain	SUSHI	CD55 SEZ6L SEZ6	4.01e-04	56	48	3	PS50923
Domain	TIL	SSPOP MUC5AC	4.20e-04	12	48	2	PF01826
Domain	C8	SSPOP MUC5AC	4.20e-04	12	48	2	PF08742
Domain	Sushi_SCR_CCP_dom	CD55 SEZ6L SEZ6	4.23e-04	57	48	3	IPR000436
Domain	CUB_dom	TMPRSS15 SEZ6L SEZ6	4.23e-04	57	48	3	IPR000859
Domain	Unchr_dom_Cys-rich	SSPOP MUC5AC	4.95e-04	13	48	2	IPR014853
Domain	C8	SSPOP MUC5AC	4.95e-04	13	48	2	SM00832
Domain	TIL_dom	SSPOP MUC5AC	5.77e-04	14	48	2	IPR002919
Domain	VWD	SSPOP MUC5AC	7.58e-04	16	48	2	SM00216
Domain	VWF_type-D	SSPOP MUC5AC	7.58e-04	16	48	2	IPR001846
Domain	VWFD	SSPOP MUC5AC	7.58e-04	16	48	2	PS51233
Domain	VWD	SSPOP MUC5AC	7.58e-04	16	48	2	PF00094
Domain	CTCK_1	SSPOP MUC5AC	9.64e-04	18	48	2	PS01185
Domain	FA58C	DDR2 SSPOP	1.32e-03	21	48	2	SM00231
Domain	FA58C_3	DDR2 SSPOP	1.32e-03	21	48	2	PS50022
Domain	FA58C_1	DDR2 SSPOP	1.32e-03	21	48	2	PS01285
Domain	FA58C_2	DDR2 SSPOP	1.32e-03	21	48	2	PS01286
Domain	TRYPSIN_SER	TMPRSS15 PLG KLK13	1.60e-03	90	48	3	IPR033116
Domain	F5_F8_type_C	DDR2 SSPOP	1.72e-03	24	48	2	PF00754
Domain	FA58C	DDR2 SSPOP	1.72e-03	24	48	2	IPR000421
Domain	Cys_knot_C	SSPOP MUC5AC	1.87e-03	25	48	2	IPR006207
Domain	CTCK_2	SSPOP MUC5AC	1.87e-03	25	48	2	PS01225
Domain	HormR	ADGRB1 ADGRL3	1.87e-03	25	48	2	SM00008
Domain	hEGF	JAG2 NOTCH4	2.34e-03	28	48	2	PF12661
Domain	HRM	ADGRB1 ADGRL3	2.34e-03	28	48	2	PF02793
Domain	VWC	VWCE MUC5AC	2.34e-03	28	48	2	PF00093
Domain	TRYPSIN_HIS	TMPRSS15 PLG KLK13	2.35e-03	103	48	3	IPR018114
Domain	TRYPSIN_SER	TMPRSS15 PLG KLK13	2.55e-03	106	48	3	PS00135
Domain	TRYPSIN_HIS	TMPRSS15 PLG KLK13	2.62e-03	107	48	3	PS00134
Domain	Peptidase_S1A	TMPRSS15 PLG KLK13	3.06e-03	113	48	3	IPR001314
Domain	TRYPSIN_DOM	TMPRSS15 PLG KLK13	3.21e-03	115	48	3	PS50240
Domain	Tryp_SPc	TMPRSS15 PLG KLK13	3.38e-03	117	48	3	SM00020
Domain	GPS	ADGRB1 ADGRL3	3.44e-03	34	48	2	SM00303
Domain	GPS	ADGRB1 ADGRL3	3.65e-03	35	48	2	PF01825
Pathway	KEGG_MEDICUS_REFERENCE_PLASMIN_MEDIATED_ACTIVATION_OF_LATENT_TGF_BETA	FBN1 PLG	1.22e-04	8	30	2	M47850
Pathway	PID_NOTCH_PATHWAY	JAG2 SSPOP NOTCH4	2.61e-04	59	30	3	M17
Pathway	KEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY	JAG2 NOTCH4	3.37e-04	13	30	2	M47423
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	SSPOP MUC5AC NOTCH4	3.97e-04	68	30	3	M27303
Pathway	KEGG_MEDICUS_VARIANT_NOTCH_OVEREXPRESSION_TO_NOTCH_SIGNALING_PATHWAY	JAG2 NOTCH4	5.16e-04	16	30	2	M47424
Pubmed	Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.	JAG2 MUC5AC NOTCH4 FOXJ1	3.68e-07	41	50	4	22675208
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	ADO ZNF618 ADGRB1 EIF3D PFKL PFKP ZNF831 SSPOP CABLES1	9.35e-07	736	50	9	29676528
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	FBN1 UNK SSPOP MUC5AC	3.42e-06	71	50	4	33541421
Pubmed	E3 ubiquitin ligase FBXW7 balances airway cell fates.	MUC5AC NOTCH4 FOXJ1	4.22e-06	22	50	3	34998785
Pubmed	Genomic organization, 5'flanking region and tissue-specific expression of mouse phosphofructokinase C gene.	PFKL PFKP	6.07e-06	3	50	2	11137296
Pubmed	Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches.	PFKL PFKP	6.07e-06	3	50	2	33141153
Pubmed	Phosphofructokinase (PFK) isozymes in man. I. Studies of adult human tissues.	PFKL PFKP	6.07e-06	3	50	2	156693
Pubmed	Functional expression of human mutant phosphofructokinase in yeast: genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency.	PFKL PFKP	6.07e-06	3	50	2	7825568
Pubmed	p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP.	CMBL PFKP	6.07e-06	3	50	2	37967006
Pubmed	Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system.	PFKL PFKP	6.07e-06	3	50	2	6451249
Pubmed	Characterization of the enzymatic defect in late-onset muscle phosphofructokinase deficiency. New subtype of glycogen storage disease type VII.	PFKL PFKP	6.07e-06	3	50	2	2960695
Pubmed	Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system.	PFKL PFKP	6.07e-06	3	50	2	6444721
Pubmed	Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.	SEZ6L SEZ6	6.07e-06	3	50	2	27716410
Pubmed	Phosphofructokinase isozyme expression during myoblast differentiation.	PFKL PFKP	6.07e-06	3	50	2	2521854
Pubmed	Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development.	MUC5AC NOTCH4 FOXJ1	7.98e-06	27	50	3	21791528
Pubmed	Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.	FBN1 SOX18 NOTCH4	7.98e-06	27	50	3	35894043
Pubmed	Notch signaling in stomach epithelial stem cell homeostasis.	JAG2 MUC5AC NOTCH4	9.95e-06	29	50	3	21402740
Pubmed	Tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton.	FBN1 SOX18	1.21e-05	4	50	2	176891
Pubmed	Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression.	JAG2 MUC5AC	1.21e-05	4	50	2	22691042
Pubmed	The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways.	JAG2 MUC5AC FOXJ1	1.48e-05	33	50	3	23213461
Pubmed	Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells.	JAG2 NOTCH4	2.02e-05	5	50	2	21602525
Pubmed	Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development.	DYNC2H1 MUC5AC FOXJ1	2.66e-05	40	50	3	32317081
Pubmed	Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.	VLDLR CD55 CYFIP2 CABLES1	3.99e-05	132	50	4	26439863
Pubmed	Human ligands of the Notch receptor.	JAG2 NOTCH4	4.23e-05	7	50	2	10079256
Pubmed	The distribution of Notch receptors and their ligands during articular cartilage development.	JAG2 NOTCH4	4.23e-05	7	50	2	12846471
Pubmed	Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.	JAG2 NOTCH4	5.64e-05	8	50	2	9858718
Pubmed	Sequencing analysis of forty-eight human image cDNA clones similar to Drosophila mutant protein.	JAG2 CAPN15	5.64e-05	8	50	2	10524757
Pubmed	Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system.	JAG2 NOTCH4	7.25e-05	9	50	2	11118901
Pubmed	Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.	JAG2 NOTCH4	7.25e-05	9	50	2	16245338
Pubmed	Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad.	JAG2 NOTCH4	7.25e-05	9	50	2	11944948
Pubmed	Notch signaling is essential for vascular morphogenesis in mice.	JAG2 NOTCH4	7.25e-05	9	50	2	10837027
Pubmed	Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.	JAG2 NOTCH4	9.05e-05	10	50	2	23665443
Pubmed	GemC1 controls multiciliogenesis in the airway epithelium.	MUC5AC FOXJ1	9.05e-05	10	50	2	26882546
Pubmed	Expression analysis of the regenerating gene (Reg) family members Reg-IIIβ and Reg-IIIγ in the mouse during development.	MUC5AC FOXJ1	9.05e-05	10	50	2	21681751
Pubmed	Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.	SOX18 NOTCH4	9.05e-05	10	50	2	17496152
Pubmed	NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation.	CYFIP2 CABLES1	9.05e-05	10	50	2	17101133
Pubmed	Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development.	JAG2 NOTCH4	1.10e-04	11	50	2	16607638
Pubmed	Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators.	JAG2 NOTCH4	1.10e-04	11	50	2	10878608
Pubmed	The expression of Sox17 identifies and regulates haemogenic endothelium.	SOX18 NOTCH4	1.10e-04	11	50	2	23604320
Pubmed	E2f4 is required for normal development of the airway epithelium.	MUC5AC FOXJ1	1.10e-04	11	50	2	17383628
Pubmed	VEGF receptor 2 (KDR) protects airways from mucus metaplasia through a Sox9-dependent pathway.	MUC5AC FOXJ1	1.10e-04	11	50	2	34010630
Pubmed	Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions.	JAG2 NOTCH4	1.10e-04	11	50	2	12866128
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	FBN1 HMCN2 PLG SSPOP	1.19e-04	175	50	4	28071719
Pubmed	Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.	JAG2 NOTCH4	1.32e-04	12	50	2	15465494
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	DYNC2H1 ZNF618 EIF3D MUC5AC	1.54e-04	187	50	4	26460568
Pubmed	Conditional stabilization of beta-catenin expands the pool of lung stem cells.	MUC5AC FOXJ1	1.56e-04	13	50	2	18356571
Pubmed	Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.	JAG2 NOTCH4	1.56e-04	13	50	2	11578869
Pubmed	Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family.	SEZ6L SEZ6	1.56e-04	13	50	2	16814779
Pubmed	The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.	DYNC2H1 FOXJ1	1.56e-04	13	50	2	17884984
Pubmed	Molecular Profiling of the Developing Lacrimal Gland Reveals Putative Role of Notch Signaling in Branching Morphogenesis.	JAG2 NOTCH4	1.82e-04	14	50	2	28192800
Pubmed	Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1.	JAG2 NOTCH4	1.82e-04	14	50	2	18528438
Pubmed	Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.	JAG2 NOTCH4	1.82e-04	14	50	2	14757642
Pubmed	Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors.	JAG2 FOXJ1	1.82e-04	14	50	2	25564622
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	DDR2 ADGRB1 ATP2B1 CYFIP2 CABLES1	2.07e-04	377	50	5	38117590
Pubmed	Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.	JAG2 NOTCH4	2.10e-04	15	50	2	12971992
Pubmed	β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium.	MUC5AC FOXJ1	2.10e-04	15	50	2	22421361
Pubmed	Identification of a proximal progenitor population from murine fetal lungs with clonogenic and multilineage differentiation potential.	MUC5AC FOXJ1	2.10e-04	15	50	2	25358791
Pubmed	Expression of Notch pathway components in fetal and adult mouse small intestine.	JAG2 NOTCH4	2.40e-04	16	50	2	12617809
Pubmed	Notch gene expression during pancreatic organogenesis.	JAG2 NOTCH4	2.40e-04	16	50	2	10842072
Pubmed	An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.	JAG2 NOTCH4	2.40e-04	16	50	2	17273555
Pubmed	Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.	JAG2 NOTCH4	2.72e-04	17	50	2	18694942
Pubmed	Segmental expression of Notch and Hairy genes in nephrogenesis.	JAG2 NOTCH4	2.72e-04	17	50	2	15821257
Pubmed	Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1.	DYNC2H1 FOXJ1	2.72e-04	17	50	2	22357932
Pubmed	Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching.	PFKL PFKP	3.05e-04	18	50	2	28049690
Pubmed	Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling.	JAG2 NOTCH4	3.05e-04	18	50	2	18093989
Pubmed	RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.	JAG2 NOTCH4	3.05e-04	18	50	2	15689374
Pubmed	Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation.	FBN1 FOXJ1	3.41e-04	19	50	2	18258849
Pubmed	Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium.	JAG2 NOTCH4	3.41e-04	19	50	2	16518823
Pubmed	Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap.	MUC5AC FOXJ1	3.41e-04	19	50	2	26235047
Pubmed	Genome-wide association study of blood pressure and hypertension.	ZNF831 ATP2B1	3.41e-04	19	50	2	19430479
Pubmed	The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors.	MUC5AC FOXJ1	3.41e-04	19	50	2	25043473
Pubmed	Sox17 is indispensable for acquisition and maintenance of arterial identity.	SOX18 NOTCH4	3.79e-04	20	50	2	24153254
Pubmed	Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception.	JAG2 NOTCH4	4.18e-04	21	50	2	28656980
Pubmed	Conversion of biliary system to pancreatic tissue in Hes1-deficient mice.	JAG2 NOTCH4	4.18e-04	21	50	2	14702043
Pubmed	Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.	DYNC2H1 RNF187	4.18e-04	21	50	2	24057671
Pubmed	Jagged and Delta-like ligands control distinct events during airway progenitor cell differentiation.	JAG2 FOXJ1	4.18e-04	21	50	2	31631837
Pubmed	ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.	DYNC2H1 FOXJ1	4.59e-04	22	50	2	25294941
Pubmed	Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.	JAG2 NOTCH4	5.03e-04	23	50	2	14701881
Pubmed	Rbpj regulates development of prosensory cells in the mammalian inner ear.	JAG2 NOTCH4	5.48e-04	24	50	2	21420948
Pubmed	Notch signaling controls liver development by regulating biliary differentiation.	JAG2 NOTCH4	6.44e-04	26	50	2	19369401
Pubmed	Excess neuropeptides in lung signal through endothelial cells to impair gas exchange.	MUC5AC FOXJ1	6.95e-04	27	50	2	35303432
Pubmed	The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.	ADGRB1 ADGRL3	8.02e-04	29	50	2	15203201
Pubmed	Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms.	JAG2 NOTCH4	8.02e-04	29	50	2	24971735
Pubmed	EGFL7 is expressed in bone microenvironment and promotes angiogenesis via ERK, STAT3, and integrin signaling cascades.	JAG2 NOTCH4	8.02e-04	29	50	2	24909139
Pubmed	Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells.	JAG2 NOTCH4	8.02e-04	29	50	2	25535917
Pubmed	Notch signaling regulates ovarian follicle formation and coordinates follicular growth.	JAG2 NOTCH4	8.59e-04	30	50	2	24552588
Pubmed	ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling.	JAG2 NOTCH4	9.17e-04	31	50	2	37573008
Pubmed	The NANCI-Nkx2.1 gene duplex buffers Nkx2.1 expression to maintain lung development and homeostasis.	MUC5AC FOXJ1	9.77e-04	32	50	2	28546511
Pubmed	International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.	ADGRB1 ADGRL3	1.04e-03	33	50	2	25713288
Pubmed	Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis.	JAG2 NOTCH4	1.10e-03	34	50	2	21311046
Pubmed	Notch signaling regulates smooth muscle differentiation of epicardium-derived cells.	JAG2 NOTCH4	1.17e-03	35	50	2	21252157
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	JAG2 CPAMD8 SMPDL3B TM7SF3 FNIP1 PFKL SSPOP ATP2B1	1.20e-03	1489	50	8	28611215
Pubmed	Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.	PFKL PFKP ATP2B1	1.25e-03	147	50	3	16959763
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	UHMK1 EXTL1 EIF3D FOXJ1	1.29e-03	329	50	4	17474147
Pubmed	MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.	CD55 PFKL PFKP ATP2B1 CYFIP2	1.29e-03	565	50	5	20458337
Pubmed	Notch signaling in postnatal pituitary expansion: proliferation, progenitors, and cell specification.	JAG2 NOTCH4	1.31e-03	37	50	2	24673559
Pubmed	Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells.	JAG2 NOTCH4	1.31e-03	37	50	2	27631609
Cytoband	22q12.1	HSCB SEZ6L	5.65e-04	32	50	2	22q12.1
Cytoband	1q23.3	DDR2 UHMK1	1.32e-03	49	50	2	1q23.3
Cytoband	Ensembl 112 genes in cytogenetic band chr22q12	HSCB EIF3D SEZ6L	2.17e-03	235	50	3	chr22q12
Cytoband	17q25.1	UNK FOXJ1	3.57e-03	81	50	2	17q25.1
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CD55 SEZ6L SEZ6	1.14e-04	57	30	3	1179
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CPAMD8 FBN1 AARD DDR2 GYG2 EXTL1	9.66e-08	200	50	6	b5a54b9baf79aea01f76a161f0a39bbe87eb4945
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CPAMD8 FBN1 AARD DDR2 GYG2 EXTL1	9.66e-08	200	50	6	f5bd0b30e478dac09f68c46b0781f5f2e7e3c693
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	JAG2 CPAMD8 HMCN2 SOX18 NOTCH4	1.30e-06	169	50	5	c7fc3a8c44f07c557b60d469717b66e2f5863d38
ToppCell	severe_COVID-19-HSPC\|severe_COVID-19 / disease group, cell group and cell class (v2)	CMBL FBN1 SMPDL3B SOX18 CABLES1	1.50e-06	174	50	5	6d35bacf073537b272ff821e604c899fb9ce6a7c
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VLDLR FBN1 DDR2 CD55 SEZ6L	2.37e-06	191	50	5	9214655dca96d766737c9f30b624d7fe7050342e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	JAG2 CPAMD8 FBN1 SOX18 NOTCH4	2.50e-06	193	50	5	0b328f725f6feba263783eaca60c142e80df90f3
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYNC2H1 FNIP1 ATP2B1 CYFIP2 SEZ6L	2.63e-06	195	50	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYNC2H1 FNIP1 ATP2B1 CYFIP2 SEZ6L	2.63e-06	195	50	5	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	JAG2 CPAMD8 FBN1 SOX18 NOTCH4	2.63e-06	195	50	5	77e47d2e8b3eb7f7c9620369ccaf87581f923bdb
ToppCell	11.5-Distal-Epithelial-Bud_tip_progenitor\|Distal / Age, Tissue, Lineage and Cell class	SMPDL3B CD55 PLCH1 CABLES1 FOXJ1	2.69e-06	196	50	5	42eae265e2f2082983d8c2607c7f6a53a526d124
ToppCell	COVID-19-COVID-19_Severe-Others-HSPC\|COVID-19_Severe / Disease, condition lineage and cell class	CMBL FBN1 ZNF618 TM7SF3 CABLES1	2.90e-06	199	50	5	25de67b6c9c8d6bb9a538e071a40ef865906c95d
ToppCell	Bronchial-10x5prime-Hematologic-Erythrocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SSPOP ADGRL3 SEZ6L SEZ6	1.22e-05	126	50	4	65c7c0e4cfb5ac58d80b4034d42e9f662116e0d3
ToppCell	Bronchial-10x5prime-Hematologic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SSPOP ADGRL3 SEZ6L SEZ6	1.22e-05	126	50	4	b6482ef18e6d9e12ba4810ce7845f9f991cb95bc
ToppCell	Bronchial-10x5prime-Hematologic-Erythrocyte-Erythrocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SSPOP ADGRL3 SEZ6L SEZ6	1.22e-05	126	50	4	12f3d0f60db462f2a9799b3a06005bc871670760
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JAG2 UHMK1 BRAT1 CYFIP2	2.90e-05	157	50	4	a426c54fd1545093d41426e9620862f71bd06f6b
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 HMCN2 DDR2 ADGRL3	3.05e-05	159	50	4	cfb4a8c8aac34b1a857956d98382d487abcf5444
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBN1 HMCN2 DDR2 ADGRL3	3.05e-05	159	50	4	a75ab494959575143cefdaec99e7aee3f318d559
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related-Tuft\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLG HMX2 PLCH1 KLK13	3.20e-05	161	50	4	f5df8c6a340d5026726804b103e32137f363ca40
ToppCell	severe-HSPC\|severe / disease stage, cell group and cell class	CMBL VLDLR FBN1 ADGRB1	3.52e-05	165	50	4	acd837d88ad3786c263f74651a6c0e02fa2fa2c5
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	JAG2 CPAMD8 HMCN2 NOTCH4	3.52e-05	165	50	4	a74751e0ec857aa974bec04ccc747c004a8f6e01
ToppCell	E16.5-Endothelial-Endothelial_lymphatic\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SOX18 ZNF831 BRAT1 SEZ6	3.69e-05	167	50	4	b93103a868fba63a8910bffb690a6242b9252833
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SOX18 ZNF831 BRAT1 SEZ6	3.69e-05	167	50	4	fcd583b1efd0ac883379982ea8e6c54f2c0be268
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SOX18 ZNF831 BRAT1 SEZ6	3.69e-05	167	50	4	f6bc63138b7239211fa5f27a8dc799b6e022c0f8
ToppCell	E16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SOX18 ZNF831 BRAT1 SEZ6	3.69e-05	167	50	4	26cd8ee5e826e71eaf58d10a906543a6932fb3f9
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D122\|Adult / Lineage, Cell type, age group and donor	JAG2 CPAMD8 SOX18 NOTCH4	3.78e-05	168	50	4	8c3e1e45b422813bcdfa4273b1167db649a312f5
ToppCell	severe-HSPC\|World / disease stage, cell group and cell class	CMBL FBN1 ADGRB1 VWCE	3.87e-05	169	50	4	b0421b73bfdc92f7a2762b4b670b9eae124aa702
ToppCell	primary_auditory_cortex_(A1C)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CPAMD8 HMCN2 PLCH1 RNF187	4.14e-05	172	50	4	20ea9db009370aa6235365ce93e153eb5b28db94
ToppCell	368C-Endothelial_cells-Endothelial-B_(Artery)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	JAG2 CPAMD8 SOX18 NOTCH4	4.24e-05	173	50	4	ec88e871b49331fca59bc610a8ae58e2d5e76bc1
ToppCell	368C-Endothelial_cells-Endothelial-B_(Artery)\|368C / Donor, Lineage, Cell class and subclass (all cells)	JAG2 CPAMD8 SOX18 NOTCH4	4.24e-05	173	50	4	22200fe74e33e2beae0eed289ca8476bbc0b1b2d
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF618 PLCH1 VWCE TEDC1	4.33e-05	174	50	4	0fccd90ef72ec2e5eb369fe6d6d126c60886485a
ToppCell	NS-critical-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CMBL DYNC2H1 VWCE FOXJ1	4.53e-05	176	50	4	b794275fdd757b8fa2108e3c867f23da2649146d
ToppCell	wk_20-22-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	JAG2 CPAMD8 HMCN2 SOX18	4.53e-05	176	50	4	52af8f717dbd3b59eeb868b8b7b256a8f3e57d7a
ToppCell	wk_08-11-Epithelial-PNS-FGFBP2+_Neural_progenitor\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	TMEM198 ADGRB1 HMX2 SEZ6L	4.63e-05	177	50	4	15a5c96ea840376e54933ebe7a8334a11d9ce411
ToppCell	severe_COVID-19-HSPC\|World / disease group, cell group and cell class (v2)	CMBL FBN1 SMPDL3B CABLES1	4.63e-05	177	50	4	289f6aed6f054b04b01659434d8c8b467d1bf5dd
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-Tuft\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMEM198 PLG HMX2 KLK13	4.73e-05	178	50	4	f17c3b7bb562ac24c6a03fe3c9ba94c2b434c141
ToppCell	control-Others-CD34+_GATA2+_cells\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CMBL FBN1 ZNF618 CABLES1	4.73e-05	178	50	4	2120bd3e099b0b271bf079db9827a2f3eee2f909
ToppCell	343B-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|343B / Donor, Lineage, Cell class and subclass (all cells)	TMEM198 UNK ZNF831 SEZ6	4.73e-05	178	50	4	5289ac61637224ae70ffbc2d164d73116f10af40
ToppCell	343B-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TMEM198 UNK ZNF831 SEZ6	4.73e-05	178	50	4	8151e5d73407fd9cba382b69a2bc707c81790c7f
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	JAG2 CPAMD8 FBN1 NOTCH4	4.84e-05	179	50	4	1ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FBN1 HMCN2 DDR2 ADGRL3	4.94e-05	180	50	4	f2f6e83127a4a415e65c76a35efa8175fbd5b5d9
ToppCell	PCW_05-06-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	JAG2 HMCN2 SOX18 NOTCH4	4.94e-05	180	50	4	5861b44acfb8fe92c281c8355bf19c059b3dcd64
ToppCell	5'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	JAG2 CPAMD8 SOX18 NOTCH4	5.16e-05	182	50	4	0639011cdd1c437ea8b7230896a4e6e5d7244ac2
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS15 PLCH1 SSPOP ADGRL3	5.38e-05	184	50	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	343B-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TMEM198 UNK ZNF831 SEZ6	5.38e-05	184	50	4	2c2125b8030af83f7a6d59a7102d4de8e0ac1988
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS15 PLCH1 SSPOP ADGRL3	5.38e-05	184	50	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS15 PLCH1 SSPOP ADGRL3	5.38e-05	184	50	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JAG2 FBN1 SOX18 NOTCH4	5.50e-05	185	50	4	f98af3146ec2f44c30d31a662fb9c4fa3ca4f706
ToppCell	COVID-19-Heart-Fib_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FBN1 HMCN2 DDR2 ADGRL3	5.50e-05	185	50	4	8f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCell	facs-Skin-Anagen-3m-Epithelial-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDR2 CD55 EXTL1 PFKP	5.61e-05	186	50	4	9a7932d0a208f3997216bd21a72913cc82b59fc9
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma-proliferating_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	JAG2 HMCN2 SOX18 NOTCH4	5.61e-05	186	50	4	a844d4f79e0ad5d6c60a4488ffd8f4f21b7eed04
ToppCell	15-Trachea-Epithelial-Secretory_progenitor\|Trachea / Age, Tissue, Lineage and Cell class	CPAMD8 AARD CD55 KLK13	5.73e-05	187	50	4	be9fce9e74b2f170a2067f1b31d802912a578329
ToppCell	droplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JAG2 FBN1 SOX18 NOTCH4	5.73e-05	187	50	4	e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCell	droplet-Kidney-nan-3m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JAG2 FBN1 SOX18 NOTCH4	5.85e-05	188	50	4	ec0e241de2c8310b4417b9d4e2420d7a1662f1c0
ToppCell	COVID-19-Heart-Fib_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FBN1 HMCN2 DDR2 ADGRL3	5.85e-05	188	50	4	fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCell	Endothelial-endothelial_cell_of_artery\|World / Lineage, Cell type, age group and donor	JAG2 CPAMD8 SOX18 NOTCH4	5.97e-05	189	50	4	fdd89c71113ac99b7c800c6def8888e512ff1128
ToppCell	droplet-Limb_Muscle-nan-24m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VLDLR FBN1 DDR2 CD55	5.97e-05	189	50	4	6e52cac679e0541ca5f2be316bdabdbc34da6e18
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	JAG2 CPAMD8 FBN1 NOTCH4	5.97e-05	189	50	4	12b6f1c3bf526b90e112374bf937701f645c5780
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	JAG2 CPAMD8 SOX18 NOTCH4	6.10e-05	190	50	4	bf9bc57a605c7e3979bc4f7260e6fb92c3eb8690
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|kidney / Disease (COVID-19 only), tissue and cell type	JAG2 FBN1 SOX18 NOTCH4	6.10e-05	190	50	4	1519f34d31fe0817184c5865a0bc9f0cb479b1a4
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBN1 DDR2 ATP2B1 ADGRL3	6.10e-05	190	50	4	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	LV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	FBN1 DYNC2H1 DDR2 ADGRL3	6.10e-05	190	50	4	12992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCell	10x5'v1-week_12-13-Endothelial-stroma-tip_EC\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	JAG2 FBN1 SOX18 NOTCH4	6.22e-05	191	50	4	cf1a67b7c0d5c0dc5d4d59faf9d9b1a3a1fb00e0
ToppCell	RV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	FBN1 DYNC2H1 DDR2 ADGRL3	6.22e-05	191	50	4	70c067c54084bfb02c29bab085f4defd477194fb
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JAG2 FBN1 SOX18 NOTCH4	6.22e-05	191	50	4	b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	JAG2 HMCN2 SOX18 NOTCH4	6.35e-05	192	50	4	3259cb89d6bcf0a3c6ff1f64d85e8a1f54124e91
ToppCell	facs-Aorta-Heart-3m-Mesenchymal\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VLDLR FBN1 DDR2 CD55	6.35e-05	192	50	4	0dc1f46e40346ed0b286e53b106a812441575100
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	JAG2 FBN1 SOX18 NOTCH4	6.48e-05	193	50	4	2e72309607902dabe3218888b22a77fe941f3570
ToppCell	IPF-Endothelial-VE_Arterial\|IPF / Disease state, Lineage and Cell class	JAG2 CPAMD8 SOX18 NOTCH4	6.48e-05	193	50	4	bf83b1fe9d38408f30eee4eb634341c04ef82791
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AARD DDR2 CD55 SOX18	6.48e-05	193	50	4	2483bb7f398e4fa0ef09c8bd584ed25703853f03
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	JAG2 HMCN2 SOX18 NOTCH4	6.48e-05	193	50	4	cc355b2ed6510619cad969ae074126d7c8db784d
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SMPDL3B CD55 PLCH1 FOXJ1	6.48e-05	193	50	4	ab78fb1603ea6f720ba2d30148fe65dccf271fe1
ToppCell	IPF-Endothelial-VE_Arterial\|World / Disease state, Lineage and Cell class	JAG2 CPAMD8 SOX18 NOTCH4	6.48e-05	193	50	4	70a9aadda83a97e06e9bc2d1327ce60dd3c58767
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	JAG2 CPAMD8 SOX18 NOTCH4	6.48e-05	193	50	4	6a623acd1adad9a78eddc32ffedb16352ad3fdfa
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CD55 HMX2 PLCH1 MUC5AC	6.61e-05	194	50	4	c5ef4ff73b4e51530656002e3a2fb7264cdf533d
ToppCell	(6)_Endothelial-B_(Artery)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	JAG2 CPAMD8 SOX18 NOTCH4	6.61e-05	194	50	4	0cf4e67d4024652794b5bfdd4a71a7d98900b4c8
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FBN1 HMCN2 DDR2 ADGRL3	6.61e-05	194	50	4	439d3f17c1f4736122b330e98add9292c7036a8e
ToppCell	18-Airway-Epithelial-Secretory_progenitor\|Airway / Age, Tissue, Lineage and Cell class	SMPDL3B AARD CD55 KLK13	6.61e-05	194	50	4	9a2efa50731135a178141aae55fa8b3e022c9904
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	JAG2 FBN1 SOX18 NOTCH4	6.61e-05	194	50	4	b0c15e7e4bcf30856fb628dedd7ba82df33489f5
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_intermediate_(1)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SMPDL3B CD55 PLCH1 FOXJ1	6.74e-05	195	50	4	d67a2b489c29bfd575751c13d2a5b1efdec5240a
ToppCell	COVID-19-Heart-Fib_1\|Heart / Disease (COVID-19 only), tissue and cell type	FBN1 DYNC2H1 DDR2 ADGRL3	6.74e-05	195	50	4	f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-stromal_related\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FBN1 AARD DDR2 ADGRB1	6.74e-05	195	50	4	1be9502577267ca2a04656a99d57e3e2f124d92e
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	JAG2 HMCN2 SOX18 NOTCH4	6.74e-05	195	50	4	d35102f95bb1e419d2df05ff0a01b6c5c923acef
ToppCell	RV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	FBN1 DYNC2H1 DDR2 ADGRL3	6.74e-05	195	50	4	ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-Late_cap\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	JAG2 SOX18 ADGRL3 NOTCH4	6.74e-05	195	50	4	dfc5da514fb34a2c318a5c4c61f44049fa43960e
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	JAG2 CPAMD8 SOX18 NOTCH4	6.88e-05	196	50	4	cf7f384c1771274e766bab03ecc3dfbd13f2df60
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	JAG2 HMCN2 SOX18 NOTCH4	6.88e-05	196	50	4	a20a56d8997d6db2a10046c8801c619a379de83c
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VLDLR FBN1 DDR2 CD55	6.88e-05	196	50	4	2029f58ce6a7b8c35d3a7496c3341391990909ce
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	JAG2 FBN1 SOX18 NOTCH4	7.01e-05	197	50	4	ad4a3b5da2190be9495382a2952991e1de9f190d
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-prox-progenitor_intermediate_\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SMPDL3B AARD CD55 FOXJ1	7.15e-05	198	50	4	1eb49b853a9e144e840c660060473fc7873f6478
ToppCell	5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	JAG2 CPAMD8 SOX18 NOTCH4	7.15e-05	198	50	4	8a55589b9244283e4b0b423a4a6d6202e8e0fec9
ToppCell	Tracheal-10x5prime-Stromal-Chondrocytic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CPAMD8 AARD EXTL1 SEZ6L	7.15e-05	198	50	4	c72ef2ddcbb6dacbed4c6200d89e17d57314dcdc
ToppCell	Tracheal-10x5prime-Stromal-Chondrocytic-Chondrocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CPAMD8 AARD EXTL1 SEZ6L	7.15e-05	198	50	4	55f013e9e6587d9ece59751fa131b1d22d6cceea
ToppCell	5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	JAG2 CPAMD8 SOX18 NOTCH4	7.15e-05	198	50	4	58508a8df2714d769f137794c29441a7bd38b350
ToppCell	MS-Multiple_Sclerosis-Others-HSPC\|Multiple_Sclerosis / Disease, condition lineage and cell class	SMPDL3B ZNF618 TMEM198 CABLES1	7.29e-05	199	50	4	7f4a22207a8b27af9a070d289e31ebd0e57af1a6
ToppCell	wk_20-22-Endothelial-Blood_vessel_endothelial\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	JAG2 SOX18 ADGRL3 NOTCH4	7.29e-05	199	50	4	243b7c72f83c12a34d8ea300fca63b04216268a4
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	JAG2 CPAMD8 SOX18 NOTCH4	7.44e-05	200	50	4	ac6b8bc9998d303f788511b8f111e682ea9f3df8
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Artery-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	JAG2 CPAMD8 SOX18 NOTCH4	7.44e-05	200	50	4	622206c33640cb2694fe158e8dc55515bb7bd4f5
ToppCell	Parenchyma_COVID-19-Endothelial-TX-Artery\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	JAG2 CPAMD8 SOX18 NOTCH4	7.44e-05	200	50	4	34b279804475ea58fbb052b96f44128c082627a9
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Artery\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	JAG2 CPAMD8 SOX18 NOTCH4	7.44e-05	200	50	4	5b4a54cd81bc4d9f5e92798362239e1aa1b70bee
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Artery\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	JAG2 CPAMD8 SOX18 NOTCH4	7.44e-05	200	50	4	8552cc7a439449b30b59760c3e8667217b9852b5
Disease	glycogen storage disease (implicated_via_orthology)	PFKL PFKP	1.55e-05	4	48	2	DOID:2747 (implicated_via_orthology)
Disease	myocardial infarction	C6orf89 DYNC2H1 PLG ZNF831 ATP2B1 ADGRL3	2.15e-05	350	48	6	EFO_0000612
Disease	diastolic blood pressure, alcohol drinking	ADO C6orf89 ZNF831 ATP2B1	4.13e-05	118	48	4	EFO_0004329, EFO_0006336
Disease	systolic blood pressure, alcohol drinking	FBN1 C6orf89 ZNF831 ATP2B1	5.67e-05	128	48	4	EFO_0004329, EFO_0006335
Disease	mean arterial pressure, alcohol consumption measurement	C6orf89 ZNF831 ATP2B1	8.44e-05	52	48	3	EFO_0006340, EFO_0007878
Disease	diastolic blood pressure, alcohol consumption measurement	C6orf89 ZNF831 ATP2B1	9.45e-05	54	48	3	EFO_0006336, EFO_0007878
Disease	dementia (is_implicated_in)	VLDLR NOTCH4	1.69e-04	12	48	2	DOID:1307 (is_implicated_in)
Disease	Disproportionate short stature	FBN1 DYNC2H1 DDR2	2.72e-04	77	48	3	C0878659
Disease	interleukin 10 measurement	VLDLR DYNC2H1 FNIP1	2.82e-04	78	48	3	EFO_0004750
Disease	disease of metabolism (implicated_via_orthology)	PFKL PFKP	5.34e-04	21	48	2	DOID:0014667 (implicated_via_orthology)
Disease	mean arterial pressure, alcohol drinking	C6orf89 ZNF831 ATP2B1	5.51e-04	98	48	3	EFO_0004329, EFO_0006340
Disease	Carcinoma, Pancreatic Ductal	JAG2 NOTCH4	6.99e-04	24	48	2	C0887833
Disease	systemic scleroderma (is_implicated_in)	FBN1 NOTCH4	6.99e-04	24	48	2	DOID:418 (is_implicated_in)
Disease	Glycogen Storage Disease	GYG2 PFKL	8.86e-04	27	48	2	C0017919
Disease	lumbar disc degeneration	DYNC2H1 PFKP	9.53e-04	28	48	2	EFO_0004994
Disease	thoracic aortic aneurysm	FBN1 AARD	1.09e-03	30	48	2	EFO_0004282
Disease	spontaneous coronary artery dissection	FBN1 ATP2B1	1.17e-03	31	48	2	EFO_0010820
Disease	monocyte count	VLDLR ADO SMPDL3B DDR2 UHMK1 PLG NOTCH4 CABLES1	1.20e-03	1320	48	8	EFO_0005091
Disease	mean arterial pressure, unipolar depression	ZNF831 ATP2B1	1.25e-03	32	48	2	EFO_0003761, EFO_0006340
Disease	refractive error, self reported educational attainment	FBN1 CD55	1.41e-03	34	48	2	EFO_0004784, MONDO_0004892
Disease	Vasodilators used in cardiac diseases use measurement	DYNC2H1 ATP2B1	1.41e-03	34	48	2	EFO_0009926
Disease	cholesteryl ester 16:0 measurement	DYNC2H1 ADGRL3	1.58e-03	36	48	2	EFO_0010341

Protein segments in the cluster

Peptide	Gene	Start	Entry
EGQPCLPGGDWPACA	BRAT1	181	Q6PJG6
LWFPPRPACDFFGDG	AARD	26	Q4LEZ3
GFPAPQTGDPAAEEW	ADGRB1	346	O14514
PQADDFWCEGEPYPG	ADO	251	Q96SZ5
PDGIWDPQGPDLSNC	ADGRL3	536	Q9HAR2
AFRDFPAGEPEPEWD	ATP2B1	651	P20020
IVSWGDFPCGQPDRP	KLK13	231	Q9UKR3
EEEGAAEPRGGWACP	CAPN15	136	O75808
EEGDGAWCPEIPVEP	DDR2	66	Q16832
DCEADGQPPPDVAWL	HMCN2	3246	Q8NDA2
PPCEAWGECGAEEPP	JAG2	941	Q9Y219
QPVPDAGPWGDYLCD	SMPDL3B	51	Q92485
PTDCGGPFELWEPNT	TMPRSS15	521	P98073
NDEGEWSGPPPECRG	CD55	271	P08174
PEAPPEDGWENFMCE	PFKL	231	P17858
ACGADWVFLPESPPE	PFKP	231	Q01813
PDDGWKAPACFCPDQ	HMX2	56	A2RU54
AGGLPQDWRGPDFCP	MUC5AC	321	P98088
TICDWEGGREPPNDP	CYFIP2	516	Q96F07
GEFSAAPDPGWPDCF	GYG2	151	O15488
APDPGWPDCFNSGVF	GYG2	156	O15488
GWIPQDACGPYSPDE	DYNC2H1	4251	Q8NCM8
EEELPRPEWGEDPGF	CEFIP	891	Q711Q0
RPEWGEDPGFCAPEN	CEFIP	896	Q711Q0
DYDPNLLDDPQWPCG	CABLES1	456	Q8TDN4
GWGDPCELCPTEPDE	FBN1	2091	P35555
RDARDPDCGFSWPLP	FNIP1	21	Q8TF40
GSRGDWPPADDDDPA	CPAMD8	1531	Q8IZJ3
DNPSGWGPCAVPEQF	EIF3D	11	O15371
WDESGSGCLPPEPLF	FOXJ1	386	Q92949
GGDEDRPFPDFDPWW	C6orf89	126	Q6UWU4
GPWGPGREDRFFCPQ	HSCB	46	Q8IWL3
SPNWPEPYVEGEDCI	SEZ6L	641	Q9BYH1
PPAAWGGAPCEGDRQ	SSPOP	2746	A2VEC9
VVRFWAEEDGPFPCP	RNF187	36	Q5TA31
DNDPQGPWCYTTDPE	PLG	156	P00747
GGDCRPEDGDPEWGP	NOTCH4	1281	Q99466
GCPEPWEPLLDGGAC	NOTCH4	1611	Q99466
CPWDGRCEQDPGPGQ	EXTL1	246	Q92935
DLWELPFPCPDGFNS	ABTB1	256	Q969K4
PDFFVGQEPWDPSGD	CMBL	76	Q96DG6
GWEPPDDPDTGSECS	ZNF618	286	Q5T7W0
QCWERDGGPAQPHGP	TEDC1	416	Q86SX3
EFPIGQIWSPGDPCE	VWCE	576	Q96DN2
SPNWPEPYGRGQDCI	SEZ6	606	Q53EL9
RCVEVDCWDGPDGEP	PLCH1	341	Q4KWH8
QDDPPARRDCAWAPG	SOX18	11	P35713
APCPGSAFADREAPW	ZNF831	266	Q5JPB2
PCPNVKHGDEWGDPG	UNK	256	Q9C0B0
CAWGAEPPRFLEAFG	UHMK1	6	Q8TAS1
EPDDAFWGAPCEQPL	TMEM198	16	Q66K66
DPPPCDAGTDQDSRW	TM7SF3	176	Q9NS93
PSRWKCDGDPDCEDG	VLDLR	86	P98155
PDYCVWVPPEGQSGD	SLC4A1AP	771	Q9BWU0