Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiongamma-aminobutyric acid:sodium:chloride symporter activity

SLC6A6 SLC6A8 SLC6A12 SLC6A13

7.69e-106554GO:0005332
GeneOntologyMolecularFunctionsodium:chloride symporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13

7.94e-1017555GO:0015378
GeneOntologyMolecularFunctionsecondary active monocarboxylate transmembrane transporter activity

SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC16A7

1.49e-0919555GO:0015355
GeneOntologyMolecularFunctionmonoatomic anion:sodium symporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13

1.49e-0919555GO:0015373
GeneOntologyMolecularFunctionchloride:monoatomic cation symporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13

4.26e-0923555GO:0015377
GeneOntologyMolecularFunctionamino acid:sodium symporter activity

SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15

4.26e-0923555GO:0005283
GeneOntologyMolecularFunctiongamma-aminobutyric acid transmembrane transporter activity

SLC6A6 SLC6A8 SLC6A12 SLC6A13

6.42e-099554GO:0015185
GeneOntologyMolecularFunctionmonoatomic anion:monoatomic cation symporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13

8.28e-0926555GO:0015296
GeneOntologyMolecularFunctionamino acid:monoatomic cation symporter activity

SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15

1.49e-0829555GO:0005416
GeneOntologyMolecularFunctionorganic acid:sodium symporter activity

SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15

4.01e-0835555GO:0005343
GeneOntologyMolecularFunctionmonocarboxylate:sodium symporter activity

SLC6A6 SLC6A8 SLC6A12 SLC6A13

6.87e-0815554GO:0140161
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15

9.13e-0881556GO:0015370
GeneOntologyMolecularFunctionsymporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15 SLC16A7

1.76e-07150557GO:0015293
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15

9.01e-07119556GO:0015294
GeneOntologyMolecularFunctionmonocarboxylic acid transmembrane transporter activity

SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC16A7

4.84e-0690555GO:0008028
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15

7.40e-06171556GO:0015081
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15

1.03e-05105555GO:0015171
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15 SLC16A7

1.62e-05296557GO:0015291
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15 SLC16A7

2.19e-05207556GO:0046943
GeneOntologyMolecularFunctiontaurine:sodium symporter activity

SLC6A6 SLC6A13

2.23e-053552GO:0005369
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15 SLC16A7

2.25e-05208556GO:0005342
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13

2.40e-05125555GO:0015108
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 TRPC5 SLC6A15 ITPR2

3.80e-05465558GO:0046873
GeneOntologyMolecularFunctioncreatine transmembrane transporter activity

SLC6A8 SLC6A13

4.45e-054552GO:0005308
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13

5.94e-05151555GO:0008509
GeneOntologyMolecularFunctiontaurine transmembrane transporter activity

SLC6A6 SLC6A13

7.41e-055552GO:0005368
GeneOntologyMolecularFunctionorganic cation transmembrane transporter activity

SLC6A2 SLC6A6 SLC6A8 SLC22A15

8.05e-0583554GO:0015101
GeneOntologyMolecularFunctionmodified amino acid transmembrane transporter activity

SLC6A8 SLC6A13 SLC22A15

1.02e-0433553GO:0072349
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13

1.07e-04171555GO:0015103
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15 SLC16A7

1.50e-04293556GO:0008514
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15

1.74e-04301556GO:0022853
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 TMEM120B TRPC5 SLC6A15 ITPR2

2.89e-04793559GO:0015075
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 TRPC5 SLC6A15 ITPR2

2.99e-04627558GO:0022890
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 TMEM120B TRPC5 SLC22A15 SLC6A15 SLC16A7 ITPR2

3.17e-0411805511GO:0022857
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15 SLC16A7

3.20e-04477557GO:0022804
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 TRPC5 SLC6A15 ITPR2

4.39e-04664558GO:0008324
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

TRPC5 ITPR2

6.64e-0414552GO:0070679
GeneOntologyMolecularFunctiontransporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 TMEM120B TRPC5 SLC22A15 SLC6A15 SLC16A7 ITPR2

6.68e-0412895511GO:0005215
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 TRPC5 SLC6A15 ITPR2

1.04e-03758558GO:0015318
GeneOntologyMolecularFunctionneurotransmitter transmembrane transporter activity

SLC6A2 SLC6A15

1.51e-0321552GO:0005326
GeneOntologyMolecularFunctionpeptidase activity

TMPRSS15 UFSP2 UNC5CL ERVK-19 MME ERVK-25 USPL1

2.03e-03654557GO:0008233
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-19 ERVK-25

4.66e-0337552GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-19 ERVK-25

4.91e-0338552GO:0070001
GeneOntologyMolecularFunctionneutral L-amino acid transmembrane transporter activity

SLC6A6 SLC6A15

5.70e-0341552GO:0015175
GeneOntologyMolecularFunctionsulfur compound transmembrane transporter activity

SLC6A6 SLC6A13

1.23e-0261552GO:1901682
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

NET1 ITSN2 DOCK7 SEC23B SEC23A

1.27e-02507555GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

NET1 ITSN2 DOCK7 SEC23B SEC23A

1.27e-02507555GO:0030695
GeneOntologyBiologicalProcessamino acid transport

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC22A15 SLC6A15

8.38e-07195557GO:0006865
GeneOntologyBiologicalProcessgamma-aminobutyric acid transport

SLC6A6 SLC6A8 SLC6A12 SLC6A13

8.83e-0728554GO:0015812
GeneOntologyBiologicalProcessmodified amino acid transport

SLC6A8 SLC6A12 SLC6A13 SLC22A15

5.67e-0644554GO:0072337
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15

1.88e-05208556GO:0035725
GeneOntologyBiologicalProcessgamma-aminobutyric acid reuptake

SLC6A12 SLC6A13

4.17e-054552GO:0051936
GeneOntologyBiologicalProcesscreatine transmembrane transport

SLC6A8 SLC6A13

4.17e-054552GO:0015881
GeneOntologyBiologicalProcessorganic cation transport

SLC6A2 SLC6A6 GHSR SLC6A12 SLC6A15

4.20e-05145555GO:0015695
GeneOntologyBiologicalProcessneurotransmitter transport

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15

6.41e-05259556GO:0006836
GeneOntologyBiologicalProcessorganic acid transmembrane transport

SLC6A6 SLC6A8 SLC6A13 SLC6A15 SLC16A7

8.22e-05167555GO:1903825
GeneOntologyBiologicalProcesssodium ion transport

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15

8.91e-05275556GO:0006814
GeneOntologyBiologicalProcesscarboxylic acid transport

SLC6A6 SLC6A8 SLC6A12 SLC6A13 PLA2R1 SLC6A15 SLC16A7

1.04e-04410557GO:0046942
GeneOntologyBiologicalProcessgamma-aminobutyric acid import

SLC6A6 SLC6A13

1.04e-046552GO:0051939
GeneOntologyBiologicalProcessorganic acid transport

SLC6A6 SLC6A8 SLC6A12 SLC6A13 PLA2R1 SLC6A15 SLC16A7

1.07e-04412557GO:0015849
GeneOntologyBiologicalProcessneurotransmitter reuptake

SLC6A2 SLC6A12 SLC6A13

1.42e-0438553GO:0098810
GeneOntologyBiologicalProcesspositive regulation of gastro-intestinal system smooth muscle contraction

GHSR PTAFR

1.45e-047552GO:1904306
GeneOntologyBiologicalProcessalkanesulfonate transmembrane transport

SLC6A6 SLC6A13

1.93e-048552GO:0042918
GeneOntologyBiologicalProcesstaurine transmembrane transport

SLC6A6 SLC6A13

1.93e-048552GO:0015734
GeneOntologyBiologicalProcessregulation of gastro-intestinal system smooth muscle contraction

GHSR PTAFR

2.48e-049552GO:1904304
GeneOntologyBiologicalProcessmonocarboxylic acid transport

SLC6A8 SLC6A12 SLC6A13 PLA2R1 SLC16A7

2.56e-04213555GO:0015718
GeneOntologyBiologicalProcessamino acid transmembrane transport

SLC6A6 SLC6A12 SLC6A13 SLC6A15

2.96e-04120554GO:0003333
GeneOntologyBiologicalProcessresponse to gravity

NOX3 PTAFR

3.10e-0410552GO:0009629
GeneOntologyBiologicalProcessamino acid neurotransmitter reuptake

SLC6A12 SLC6A13

3.10e-0410552GO:0051933
GeneOntologyBiologicalProcessneurotransmitter uptake

SLC6A2 SLC6A12 SLC6A13

3.61e-0452553GO:0001504
GeneOntologyBiologicalProcessorganic anion transport

SLC6A6 SLC6A8 SLC6A12 SLC6A13 PLA2R1 SLC6A15 SLC16A7

4.18e-04515557GO:0015711
GeneOntologyBiologicalProcessamino-acid betaine transport

SLC6A12 SLC22A15

6.22e-0414552GO:0015838
GeneOntologyBiologicalProcessgastro-intestinal system smooth muscle contraction

GHSR PTAFR

7.17e-0415552GO:0014831
GeneOntologyBiologicalProcesscarboxylic acid transmembrane transport

SLC6A8 SLC6A13 SLC6A15 SLC16A7

9.37e-04163554GO:1905039
DomainNA_NEUROTRAN_SYMP_2

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15

7.93e-1218546PS00754
DomainSNF

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15

1.16e-1119546PF00209
DomainNA_NEUROTRAN_SYMP_1

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15

1.16e-1119546PS00610
DomainNA_NEUROTRAN_SYMP_3

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15

1.16e-1119546PS50267
DomainNa/ntran_symport

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15

1.16e-1119546IPR000175
Domain-

COL6A3 MDN1 SEC23B SEC23A

6.18e-05745443.40.50.410
DomainSec23/24_helical_dom

SEC23B SEC23A

1.22e-046542IPR006900
DomainSec23_24_beta_S

SEC23B SEC23A

1.22e-046542IPR012990
Domainzf-Sec23_Sec24

SEC23B SEC23A

1.22e-046542PF04810
DomainSec23_trunk

SEC23B SEC23A

1.22e-046542PF04811
DomainSec23_helical

SEC23B SEC23A

1.22e-046542PF04815
DomainSec23_BS

SEC23B SEC23A

1.22e-046542PF08033
DomainSec23/24_trunk_dom

SEC23B SEC23A

1.22e-046542IPR006896
DomainZnf_Sec23_Sec24

SEC23B SEC23A

1.22e-046542IPR006895
DomainVWF_A

COL6A3 MDN1 SEC23B SEC23A

1.92e-0499544IPR002035
DomainGelsolin

SEC23B SEC23A

7.30e-0414542PF00626
DomainGelsolin-like_dom

SEC23B SEC23A

7.30e-0414542IPR007123
DomainATPase_dyneun-rel_AAA

DNAH12 MDN1

7.30e-0414542IPR011704
DomainAAA_5

DNAH12 MDN1

7.30e-0414542PF07728
DomainADF-H/Gelsolin-like_dom

SEC23B SEC23A

2.17e-0324542IPR029006
Domain-

SEC23B SEC23A

2.17e-03245423.40.20.10
PathwayREACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS

SLC6A2 SLC6A6 SLC6A12 SLC6A13 SLC22A15 SLC6A15 SLC16A7

1.34e-0976397MM15072
PathwayREACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS

SLC6A2 SLC6A6 SLC6A12 SLC6A13 SLC6A15

1.40e-0919395M27362
PathwayREACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS

SLC6A2 SLC6A6 SLC6A12 SLC6A13 SLC6A15

1.40e-0919395MM15107
PathwayREACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS

SLC6A2 SLC6A6 SLC6A12 SLC6A13 SLC22A15 SLC6A15 SLC16A7

2.73e-0984397M27334
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC6A2 SLC6A6 SLC6A12 SLC6A13 SLC22A15 SLC6A15 SLC16A7

3.47e-06238397MM15076
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC6A2 SLC6A6 SLC6A12 SLC6A13 SLC22A15 SLC6A15 SLC16A7

4.68e-06249397M5988
PathwayWP_NRF2_PATHWAY

SLC6A2 SLC6A6 SLC6A8 SLC6A13 SLC6A15

4.08e-05141395M39454
PathwayREACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE

SLC6A6 SLC6A12 SLC6A15

9.19e-0532393MM14957
PathwayREACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE

SLC6A6 SLC6A12 SLC6A15

1.01e-0433393M188
PathwayKEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY

ADRA1B PTAFR ITPR2

3.51e-0450393M47951
PathwayREACTOME_CREATINE_METABOLISM

SLC6A8 SLC6A12

4.04e-0411392M27681
PathwayREACTOME_CREATINE_METABOLISM

SLC6A8 SLC6A12

4.04e-0411392MM15402
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC6A2 SLC6A6 SLC6A12 SLC6A13 TRPC5 SLC22A15 SLC6A15 SLC16A7

4.62e-04681398MM14985
PathwayKEGG_MEDICUS_REFERENCE_COPII_VESICLE_FORMATION

SEC23B SEC23A

4.84e-0412392M47770
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC6A2 SLC6A6 SLC6A12 SLC6A13 TRPC5 SLC22A15 SLC6A15 SLC16A7

7.73e-04736398M27287
PathwayREACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION

SLC6A12 SLC6A13

1.24e-0319392M927
PathwayREACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION

SLC6A12 SLC6A13

1.24e-0319392MM15523
PathwayWP_NUCLEAR_RECEPTORS_METAPATHWAY

SLC6A2 SLC6A6 SLC6A8 SLC6A13 SLC6A15

1.64e-03314395M39428
Pubmed

The repertoire of solute carriers of family 6: identification of new human and rodent genes.

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC6A15

7.04e-132156616125675
Pubmed

Neurotransmitter transporter family including SLC6A6 and SLC6A13 contributes to the 5-aminolevulinic acid (ALA)-induced accumulation of protoporphyrin IX and photodamage, through uptake of ALA by cancerous cells.

SLC6A6 SLC6A8 SLC6A13

3.95e-09356324842606
Pubmed

Pancreatic SEC23B deficiency is sufficient to explain the perinatal lethality of germline SEC23B deficiency in mice.

EPOR SEC23B SEC23A

2.20e-07856327297878
Pubmed

Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo.

SEC23B SEC23A

2.55e-06256230065114
Pubmed

A high density linkage disequilibrium mapping in 14 noradrenergic genes: evidence of association between SLC6A2, ADRA1B and ADHD.

SLC6A2 ADRA1B

2.55e-06256223052569
Pubmed

Cloning and functional characterization of mammalian homologues of the COPII component Sec23.

SEC23B SEC23A

2.55e-0625628898360
Pubmed

Protein kinases as regulators of osmolyte accumulation under stress conditions: An overview.

SLC6A6 SLC6A12

2.55e-06256232114438
Pubmed

Pathogenesis of membranous nephropathy: recent advances and future challenges.

PLA2R1 MME

7.63e-06356222371247
Pubmed

Astrocytic γ-aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain.

SLC6A12 SLC6A13

7.63e-06356229175673
Pubmed

Hypotaurine Is a Substrate of GABA Transporter Family Members GAT2/Slc6a13 and TAUT/Slc6a6.

SLC6A6 SLC6A13

1.52e-05456230270321
Pubmed

TANGO1/cTAGE5 receptor as a polyvalent template for assembly of large COPII coats.

SEC23B SEC23A

1.52e-05456227551091
Pubmed

ALG-2 attenuates COPII budding in vitro and stabilizes the Sec23/Sec31A complex.

SEC23B SEC23A

1.52e-05456224069399
Pubmed

Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected].

SLC6A12 SLC6A13

1.52e-0545628420981
Pubmed

Amino acid transport across mammalian intestinal and renal epithelia.

SLC6A6 SLC6A12 SLC6A15

1.72e-053156318195088
Pubmed

Embryonic and postnatal expression of four gamma-aminobutyric acid transporter mRNAs in the mouse brain and leptomeninges.

SLC6A12 SLC6A13

2.54e-0555628956109
Pubmed

Deletion of the γ-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents.

SLC6A12 SLC6A13

2.54e-05556222896705
Pubmed

Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1.

SEC23B SEC23A

3.80e-05656215642376
Pubmed

Sec24 proteins and sorting at the endoplasmic reticulum.

SEC23B SEC23A

3.80e-05656210075675
Pubmed

A family of mammalian proteins homologous to yeast Sec24p.

SEC23B SEC23A

3.80e-05656210329445
Pubmed

Mov10 and APOBEC3G localization to processing bodies is not required for virion incorporation and antiviral activity.

DCP1A APOBEC3F

5.32e-05756223926332
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

PDS5B LARP4B MDN1 DOCK7 SEC23B SEC23A DHX8

8.32e-0565356722586326
Pubmed

L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.

SLC6A2 SLC6A6 SLC6A12 SLC6A13

8.52e-0514356420424473
Pubmed

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

SLC6A6 SLC6A8 TMEM120B SLC6A15 SEC23B SEC23A ITPR2 SEMA4C

1.36e-0495256838569033
Pubmed

Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure.

SEC23B SEC23A

1.39e-041156219966784
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

SLC6A6 SLC6A8 LARP4B SLC6A15 DCP1A DHX8 ITPR2

1.70e-0473356734672954
Pubmed

Association study of 182 candidate genes in anorexia nervosa.

SLC6A2 GHSR ADRA1B MME

2.15e-0418256420468064
Pubmed

Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.

SLC6A12 SLC6A13

2.29e-041456223378610
Pubmed

Combinatorial CRISPR screen identifies fitness effects of gene paralogues.

PAXBP1 SEC23B SEC23A DCP1A

2.34e-0418656433637726
Pubmed

Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.

MDN1 SEC23B SEC23A

2.56e-047656327542412
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

SLC6A6 SLC6A8 ADRA1B DOCK7 SLC6A15 SEMA4C

3.03e-0456956630639242
Pubmed

Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.

SLC6A8 LARP4B MDN1 SLC6A15 ITPR2

3.45e-0437556532788342
Pubmed

GABA neurotransmitter signaling in the developing mouse lens: dynamic regulation of components and functionality.

SLC6A12 SLC6A13

3.83e-041856218985723
Pubmed

The ULK1-FBXW5-SEC23B nexus controls autophagy.

FBXO16 SEC23B

4.75e-042056230596474
Pubmed

Stable association between G alpha(q) and phospholipase C beta 1 in living cells.

GHSR ADRA1B PTAFR

4.93e-049556316754659
Pubmed

RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2.

PLA2R1 ITPR2

5.24e-042156231712577
Pubmed

Neural tube opening and abnormal extraembryonic membrane development in SEC23A deficient mice.

SEC23B SEC23A

5.24e-042156226494538
Pubmed

SEC23B is required for the maintenance of murine professional secretory tissues.

SEC23B SEC23A

5.76e-042256222745161
Pubmed

Co-adaptor driven assembly of a CUL3 E3 ligase complex.

SEC23B SEC23A

5.76e-042256235120648
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

LARP4B SETX PAXBP1 MDN1 NET1 KAT8 ITSN2 DHX8 SEMA4C

6.04e-04149756931527615
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

PDS5B PAXBP1 NET1 DOCK7 SEC23B SEC23A DCP1A

6.74e-0492256727609421
Pubmed

PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.

PDS5B LARP4B MDN1 DOCK7

6.82e-0424756432989298
Pubmed

Global proteomics of Ubqln2-based murine models of ALS.

TRIM4 ITSN2 SEC23B SEC23A

8.38e-0426156433277362
Pubmed

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.

SETX MDN1 SEC23B ITPR2

8.50e-0426256436880596
Pubmed

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes.

SLC6A12 NET1

8.71e-042756224550280
Pubmed

FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.

SLC6A8 UFSP2 SEC23B ITPR2 SEMA4C

9.38e-0446856531056421
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

PDS5B LARP4B SETX PAXBP1 TRIM4

9.47e-0446956527634302
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

PLA2R1 MDN1 UFSP2 NET1 KAT8 SEC23B DCP1A ITPR2

1.04e-03129356815342556
Pubmed

The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.

ITSN2 DOCK7 SEMA4C

1.09e-0312556329467281
Pubmed

A common variant in DRD3 receptor is associated with autism spectrum disorder.

SLC6A2 GHSR ADRA1B

1.17e-0312856319058789
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

PDS5B MDN1 DOCK7 SEC23A FOXC1 DHX8 ITPR2

1.24e-03102456724711643
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

LARP4B MDN1 TRIM4 SLC6A15 FOXC1 DCP1A

1.32e-0375456633060197
Pubmed

Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.

TMEM120B SYNGR1 DOCK7 ITPR2

1.33e-0329656434186245
Pubmed

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

SLC6A2 SLC6A12 SLC6A13 ADRA1B

1.40e-0330056419086053
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

SETX DOCK7 SLC6A15 SEC23B SEC23A SEMA4C

1.53e-0377756635844135
Cytoband14q21.1

SEC23A TTC6

2.38e-041955214q21.1
Cytoband6q25.3

ZDHHC14 NOX3

7.27e-04335526q25.3
GeneFamilySolute carriers

SLC6A2 SLC6A6 SLC6A8 SLC6A12 SLC6A13 SLC22A15 SLC6A15 SLC16A7

1.07e-06395378752
ToppCellprimary_visual_cortex-Non-neuronal-pericyte_cell-Peri|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC6A12 SLC6A13 PLA2R1 FOXC1 ITPR2

1.26e-06155545d8b5145258f075b15080f8739f537f48dd22225e
ToppCellprimary_visual_cortex-Non-neuronal-pericyte_cell-Peri-Peri_Kcnj8|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC6A12 SLC6A13 PLA2R1 FOXC1 ITPR2

1.26e-06155545ced64e26962c5c6e6d539f361fe57ab0b399e999
ToppCellprimary_visual_cortex-Non-neuronal-pericyte_cell|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC6A12 SLC6A13 PLA2R1 FOXC1 ITPR2

1.26e-061555450f24ef6486aef354f0911c06932cb01d1a0525ac
ToppCellTransverse-B_cell-B_cell_IgG_Plasma|B_cell / Region, Cell class and subclass

SLC6A13 COL6A3 ERVMER34-1 FOXC1 SEMA4C

4.06e-06197545a0a096e8e80763a92d5d7396eb678a4587771a3a
ToppCellprimary_visual_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Spp1_Hs3st6|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC6A12 SLC6A13 PLA2R1 FOXC1

8.72e-061075444a18261492371d19b8dbd403e197fdf64ef69392
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SLC6A12 SLC6A13 COL6A3 CATSPERG

2.66e-05142544671ba8869db7a6dc69fd1caf0e561f15a312b170
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SLC6A12 SLC6A13 COL6A3 CATSPERG

2.66e-051425443557084150670fd2e2634fc674f228ab85181b59
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Alcam_(Alcam)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SLC6A12 SLC6A13 COL6A3 CATSPERG

2.66e-051425446a656d28c9f5dfb03a3a2d908cf2edbe0a5b1206
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Alcam_(Alcam)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SLC6A12 SLC6A13 COL6A3 CATSPERG

2.66e-05142544a3d1f4b570b75402171e38c5a7c88e2896520c8f
ToppCell343B-Myeloid-Dendritic-cDC1|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

TMEM120B NET1 MYRFL TMEM229B

3.65e-0515454471d33b5dbfab5820e3daddb01806a69116ba8008
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Hippocampus / BrainAtlas - Mouse McCarroll V32

SLC6A12 SLC6A13 COL6A3 FOXC1

4.14e-0515954492049a8d8fc9997d8d0d76500c72596a9b2394e0
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma|TCGA-Endometrium / Sample_Type by Project: Shred V9

SLC6A12 SLC6A13 ADRA1B SLC6A15

4.67e-0516454408c725548e751f815b4df778607270498204b353
ToppCellfacs-Marrow-KLS-24m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPOR COL6A3 KAT8 TSPY26P

4.67e-05164544d2b5f51af7fcffddebe997ee302bacbd85d76852
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP|Hippocampus / BrainAtlas - Mouse McCarroll V32

SLC6A12 SLC6A13 COL6A3 FOXC1

5.13e-0516854426aa96b2b547d11941cb803995ea3d302ee0518c
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A2 PLA2R1 MME FOXC1

5.37e-0517054460bbd738c12e64e483485586c30057304884f5a6
ToppCelldroplet-Lung-1m-Hematologic-myeloid-interstitial_macrophage|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM120B SYNGR1 ZDHHC14 CATSPERG

5.37e-05170544f664c7559e383b37845c123e41a3be316d869ba0
ToppCelldroplet-Lung-1m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_l12|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM120B SYNGR1 ZDHHC14 CATSPERG

5.37e-051705440272eb1487c2545d4aa06f5d1cd77f823e1441e9
ToppCelldroplet-Lung-LUNG-1m-Myeloid-lung_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM120B SYNGR1 ZDHHC14 CATSPERG

5.75e-0517354469b404e92aad3e6dff67e75466f073f20a71f13f
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Interstitial_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM120B SYNGR1 ZDHHC14 CATSPERG

5.75e-0517354426bba58f9fb215d1d155504906cd77e8774f6936
ToppCellCOVID-19-kidney-tDL|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC6A13 SULT1C2 UNC5CL MME

6.70e-05180544864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCelldroplet-Marrow-nan-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRA1B NET1 TMEM229B SEMA4C

6.70e-0518054464f01494a4052186773720e10b4e7c724ff94547
ToppCellsevere-Myeloid-Neutrophils_1|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

SLC6A6 IL13RA1 MME PTAFR

7.15e-0518354460a6112aa4fc4f5debda4c7e81b37539ba2e4e6e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A12 SLC6A13 UNC5CL MME

7.61e-05186544a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCellEntopeduncular-Endothelial|Entopeduncular / BrainAtlas - Mouse McCarroll V32

IL13RA1 NET1 TMEM140 FOXC1

7.93e-0518854494774652fd42bad5012356672ffac8b6d2c22d37
ToppCellfacs-Skin-Anagen-3m-Epithelial|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A6 IL13RA1 NET1 FOXC1

8.26e-05190544888ded899f0513d41bf655896d59ae8ef74e0978
ToppCellHippocampus-Endothelial|Hippocampus / BrainAtlas - Mouse McCarroll V32

IL13RA1 PLA2R1 TMEM140 FOXC1

8.60e-0519254436deadab892d3e639a71f33697bb2d3cbbaa5372
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D122|Adult / Lineage, Cell type, age group and donor

SLC6A6 SLC22A15 MME PTAFR

8.78e-05193544cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCellControl_saline-Epithelial_alveolar-AT_2-Differentiating_AT2|Control_saline / Treatment groups by lineage, cell group, cell type

NET1 UNC5CL MME TTC6

9.50e-0519754444a59dfb889577b3160a5b13ada1276771a00241
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

NET1 UNC5CL MME TTC6

9.69e-05198544285f729140b1df029c24f6ca1d2438470ac51794
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC6A8 SULT1C2 UNC5CL MME

9.88e-05199544f26c20f5d7470e90eaa79613d0b87bd4865585a8
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC6A8 SULT1C2 UNC5CL MME

9.88e-05199544a10768e1cddd2d38291c30d24820a94040a72211
ToppCellBrain_organoid-organoid_Tanaka_cellReport-1m-Neuroepithelial|1m / Sample Type, Dataset, Time_group, and Cell type.

PLA2R1 COL6A3 MME DHX8

1.01e-04200544fe15fb050852c187f6f17fb4f6172e69fe7d74a4
ToppCellControl-Control-Myeloid-Neutrophil|Control / Disease, condition lineage and cell class

PLA2R1 MME PTAFR TMEM140

1.01e-0420054495c41f147a1594d49e73cb56d86d301c3115ce20
ToppCellBrain_organoid-organoid_Tanaka_cellReport-1m-Neuroepithelial-Proteoglycan-expressing_cell|1m / Sample Type, Dataset, Time_group, and Cell type.

PLA2R1 COL6A3 MME DHX8

1.01e-04200544d0a4c3bf9c5211defb4c1d0b6653833cccbd29ee
ToppCellControl_saline-Epithelial_alveolar-AT_1-Differentiating_AT2|Control_saline / Treatment groups by lineage, cell group, cell type

SLC6A6 NET1 UNC5CL TTC6

1.01e-04200544eac33be484dc443794e66e473f03e98406c2983e
ToppCell(50)_cDC2|World / shred on Cell_type and subtype

SLC6A2 IL13RA1 NET1 PTAFR

1.13e-04206544d519adeb8290fcce107e81a439ba3bf1e231b55b
Diseasecongenital dyserythropoietic anemia type II (implicated_via_orthology)

SEC23B SEC23A

3.05e-062522DOID:0111401 (implicated_via_orthology)
Diseasecraniolenticulosutural dysplasia (implicated_via_orthology)

SEC23B SEC23A

3.05e-062522DOID:0070307 (implicated_via_orthology)
DiseaseRoberts syndrome (implicated_via_orthology)

SEC23B SEC23A

1.82e-054522DOID:5325 (implicated_via_orthology)
Diseaseinterleukin-2 receptor subunit alpha measurement

SLC6A2 NET1

6.26e-0421522EFO_0010587
Diseasephosphatidylinositol measurement

DOCK7 TTC6 TMEM229B

6.37e-0495523EFO_0010230
Diseaseamino acid measurement

SLC6A2 SLC6A12 SLC6A13 PLA2R1 SETX DNAH12

1.19e-03678526EFO_0005134
Diseaseheart conduction disease (implicated_via_orthology)

SLC6A2 MME

1.46e-0332522DOID:10273 (implicated_via_orthology)
DiseaseSpinocerebellar Ataxia Type 2

MME FOXC1

1.65e-0334522C0752121
DiseaseSpinocerebellar Ataxia Type 1

MME FOXC1

1.65e-0334522C0752120
DiseaseSpinocerebellar Ataxia Type 5

MME FOXC1

1.65e-0334522C0752123
DiseaseSpinocerebellar Ataxia Type 7

MME FOXC1

1.65e-0334522C0752125
DiseaseSpinocerebellar Ataxia Type 6 (disorder)

MME FOXC1

1.65e-0334522C0752124
DiseaseAtaxia, Spinocerebellar

MME FOXC1

1.65e-0334522C0087012
DiseaseSpinocerebellar Ataxia Type 4

MME FOXC1

1.75e-0335522C0752122

Protein segments in the cluster

PeptideGeneStartEntry
FCNPYNNLIFIWGNF

CATSPERG

481

Q6ZRH7
KVVFWLGYFNSCLNP

ADRA1B

331

P35368
GQVALYTFCPKANQW

DCP1A

31

Q9NPI6
NNGWKYFCPICGRLF

CPXCR1

271

Q8N123
NKPLWQCYLGRFNDI

PDS5B

311

Q9NTI5
TLNPKWNFNCQFFIK

ITSN2

1611

Q9NZM3
AFRIYNCTWPNPAQK

ITPR2

1516

Q14571
WLPRLNAYRGYCSNQ

NET1

256

Q7Z628
CLNFARSLWYQQTLP

MDN1

3631

Q9NU22
KSYRFHLGQCQWRQP

KAT8

221

Q9H7Z6
FLGNIPKQYCNQILW

ERVMER34-1

136

Q9H9K5
YPNLAFCVWILNAQK

TMPRSS15

546

P98073
LPKFINCEFAYNDNW

LARP4B

261

Q92615
FFLNFAQVWCGTYRP

MME

686

P08473
LNFLQDWYNSGKPCV

DNAH12

2926

Q6ZR08
VYFSGKRQACPNWVF

MYRFL

611

Q96LU7
LAPFNQYLFNTFGWK

SLC16A7

161

O60669
KNSGPYLFFQRQFWS

PAXBP1

761

Q9Y5B6
QWENPQNFISRCLFY

IL13RA1

246

P78552
GNQLPAYKCFQITWF

APOBEC3F

76

Q8IUX4
QFCQRLGKYRMPFAW

DOCK7

386

Q96N67
YRPWNFGDLLCKLFQ

GHSR

106

Q92847
RFPFYRDNKQGWQNS

FOXC1

111

Q12948
FYLSPDIRKQCDWFQ

COL6A3

2826

P12111
KGNFQLWLYQNDGCL

EPOR

301

P19235
LKCLRFNWYINFSPT

FBXO16

131

Q8IX29
YPLCIYLINQKWFGR

SLC22A15

351

Q8IZD6
KFSNPWCYENFIQAR

DHX8

1056

Q14562
LANVWRFPYLCYKNG

SLC6A2

76

P23975
LGNVWRFPYLCQKNG

SLC6A15

81

Q9H2J7
LGNVWRFPYLCYKNG

SLC6A6

61

P31641
DLPNLRIGFYNFCLW

TMEM140

41

Q9NV12
WPNGPIYQKFRNQFL

TMEM120B

206

A0PK00
TGFILRQFNACPWDY

TMEM229B

91

Q8NBD8
YYQNQGNWILPKFLC

PTAFR

76

P25105
LGNVWRFPYLCYKNG

SLC6A12

56

P48065
GYQLGQQSLCKRFWD

SETX

546

Q7Z333
GLGNVWRFPYLCYKN

SLC6A8

71

P48029
ARLACSAPNWQLYFN

SEMA4C

281

Q9C0C4
KTFYGRPNWNNEFKQ

NOX3

506

Q9HBY0
GWLYFNYKCLLLNIP

PLA2R1

961

Q13018
KLWACNFCYQRNQFP

SEC23A

81

Q15436
KLWACNFCFQRNQFP

SEC23B

81

Q15437
FWNKDAYYNLCLPQR

UFSP2

451

Q9NUQ7
PGYCSKAFQKFLSQW

ERVK-25

711

P63136
FPQALCVQWKNAYAL

USPL1

221

Q5W0Q7
NFFTWALKINPCFLD

TTC6

231

Q86TZ1
PPSFWENNCKFLYVA

SULT1C2

116

O00338
GLGNVWRFPYLCYKN

SLC6A13

51

Q9NSD5
RIYFLNNTPCALQWA

UNC5CL

266

Q8IV45
VGFCYLANQWQVSKP

SYNGR1

121

O43759
PWVGNCVGKRNYRFF

ZDHHC14

196

Q8IZN3
SPKSFLYLGNWFNNT

TRPC5

666

Q9UL62
LYLGNWFNNTFCPKR

TRPC5

671

Q9UL62
PGYCSKAFQKFLSQW

ERVK-19

716

Q9WJR5
NYFAGWRNPQKTAFV

TRIM4

346

Q9C037
CKFKFRFWSNPYFQN

TSPY26P

236

Q9H489