Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin conjugating enzyme binding	RNF14 SIAH1 SIAH2	2.34e-05	36	31	3	GO:0031624
GeneOntologyMolecularFunction	ubiquitin-like protein conjugating enzyme binding	RNF14 SIAH1 SIAH2	3.73e-05	42	31	3	GO:0044390
GeneOntologyBiologicalProcess	gliogenesis	LRP2 LAMA2 LAMB2 LAMC3 ERBB3 TENM4 NOTCH2	3.77e-06	435	32	7	GO:0042063
GeneOntologyBiologicalProcess	axon guidance	LRP2 LAMA2 LAMB2 SIAH1 LAMC3 NOTCH2	4.42e-06	285	32	6	GO:0007411
GeneOntologyBiologicalProcess	neuron projection guidance	LRP2 LAMA2 LAMB2 SIAH1 LAMC3 NOTCH2	4.51e-06	286	32	6	GO:0097485
GeneOntologyBiologicalProcess	glial cell differentiation	LAMA2 LAMB2 LAMC3 ERBB3 TENM4 NOTCH2	8.74e-06	321	32	6	GO:0010001
GeneOntologyBiologicalProcess	Schwann cell differentiation	LAMA2 LAMB2 ERBB3	8.42e-05	55	32	3	GO:0014037
GeneOntologyBiologicalProcess	glial cell development	LAMB2 LAMC3 ERBB3 TENM4	9.84e-05	157	32	4	GO:0021782
GeneOntologyBiologicalProcess	glomerular epithelial cell development	LAMB2 NOTCH2	1.04e-04	10	32	2	GO:0072310
GeneOntologyBiologicalProcess	podocyte development	LAMB2 NOTCH2	1.04e-04	10	32	2	GO:0072015
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	LRP2 LAMA2 LAMB2 SIAH1 LAMC3 TECTA NOTCH2	1.22e-04	748	32	7	GO:0048667
GeneOntologyBiologicalProcess	regulation of basement membrane organization	LAMA2 LAMB2	1.27e-04	11	32	2	GO:0110011
GeneOntologyBiologicalProcess	axonogenesis	LRP2 LAMA2 LAMB2 SIAH1 LAMC3 NOTCH2	2.05e-04	566	32	6	GO:0007409
GeneOntologyBiologicalProcess	positive regulation of integrin-mediated signaling pathway	LAMA2 LAMB2	2.10e-04	14	32	2	GO:2001046
GeneOntologyBiologicalProcess	cell morphogenesis	LRP2 LAMA2 LAMB2 SIAH1 LAMC3 TECTA ADAM7 NOTCH2	3.72e-04	1194	32	8	GO:0000902
GeneOntologyBiologicalProcess	axon development	LRP2 LAMA2 LAMB2 SIAH1 LAMC3 NOTCH2	4.03e-04	642	32	6	GO:0061564
GeneOntologyBiologicalProcess	peripheral nervous system development	LAMA2 LAMB2 ERBB3	4.67e-04	98	32	3	GO:0007422
GeneOntologyBiologicalProcess	podocyte differentiation	LAMB2 NOTCH2	5.28e-04	22	32	2	GO:0072112
GeneOntologyBiologicalProcess	glomerular epithelial cell differentiation	LAMB2 NOTCH2	5.28e-04	22	32	2	GO:0072311
GeneOntologyBiologicalProcess	renal filtration cell differentiation	LAMB2 NOTCH2	5.28e-04	22	32	2	GO:0061318
GeneOntologyBiologicalProcess	regulation of integrin-mediated signaling pathway	LAMA2 LAMB2	5.78e-04	23	32	2	GO:2001044
GeneOntologyBiologicalProcess	glomerular epithelium development	LAMB2 NOTCH2	5.78e-04	23	32	2	GO:0072010
GeneOntologyBiologicalProcess	positive regulation of muscle cell differentiation	LAMA2 LAMB2 NOTCH2	5.87e-04	106	32	3	GO:0051149
GeneOntologyCellularComponent	protein complex involved in cell-matrix adhesion	LAMA2 LAMB2	3.04e-04	17	32	2	GO:0098637
GeneOntologyCellularComponent	extracellular matrix	LAMA2 KERA LAMB2 LAMC3 SERPINB9 TECTA	4.21e-04	656	32	6	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	LAMA2 KERA LAMB2 LAMC3 SERPINB9 TECTA	4.28e-04	658	32	6	GO:0030312
GeneOntologyCellularComponent	basement membrane	LAMA2 LAMB2 LAMC3	8.50e-04	122	32	3	GO:0005604
GeneOntologyCellularComponent	synaptic cleft	LAMA2 LAMB2	1.16e-03	33	32	2	GO:0043083
Domain	EGF-like_dom	LRP2 LAMA2 LAMB2 LAMC3 C7 TENM4 TECTA NOTCH2	9.29e-09	249	33	8	IPR000742
Domain	EGF	LRP2 LAMA2 LAMB2 LAMC3 TENM4 TECTA NOTCH2	1.48e-07	235	33	7	SM00181
Domain	EGF_1	LRP2 LAMA2 LAMB2 LAMC3 C7 TENM4 NOTCH2	2.57e-07	255	33	7	PS00022
Domain	EGF-like_CS	LRP2 LAMA2 LAMB2 LAMC3 C7 TENM4 NOTCH2	3.01e-07	261	33	7	IPR013032
Domain	EGF_2	LRP2 LAMA2 LAMB2 LAMC3 C7 TENM4 NOTCH2	3.33e-07	265	33	7	PS01186
Domain	LAMININ_NTER	LAMA2 LAMB2 LAMC3	2.77e-06	16	33	3	PS51117
Domain	Laminin_N	LAMA2 LAMB2 LAMC3	2.77e-06	16	33	3	PF00055
Domain	Laminin_N	LAMA2 LAMB2 LAMC3	2.77e-06	16	33	3	IPR008211
Domain	LamNT	LAMA2 LAMB2 LAMC3	2.77e-06	16	33	3	SM00136
Domain	Growth_fac_rcpt_	LRP2 LAMB2 LAMC3 ERBB3 NOTCH2	7.49e-06	156	33	5	IPR009030
Domain	7-in-absentia-prot_TRAF-dom	SIAH1 SIAH2	9.07e-06	3	33	2	IPR018121
Domain	Sina	SIAH1 SIAH2	9.07e-06	3	33	2	PF03145
Domain	Znf_RING/FYVE/PHD	RNF14 SIAH1 SIAH2 CHD4 KAT6B TRIM42 RBCK1	1.27e-05	459	33	7	IPR013083
Domain	RING	RNF14 SIAH1 SIAH2 CHD4 TRIM42 RBCK1	1.38e-05	305	33	6	SM00184
Domain	SINA-like	SIAH1 SIAH2	1.81e-05	4	33	2	IPR004162
Domain	Znf_SIAH	SIAH1 SIAH2	1.81e-05	4	33	2	IPR013010
Domain	EGF_LAM_2	LAMA2 LAMB2 LAMC3	1.98e-05	30	33	3	PS50027
Domain	EGF_LAM_1	LAMA2 LAMB2 LAMC3	1.98e-05	30	33	3	PS01248
Domain	Znf_RING	RNF14 SIAH1 SIAH2 CHD4 TRIM42 RBCK1	2.01e-05	326	33	6	IPR001841
Domain	ZF_SIAH	SIAH1 SIAH2	3.02e-05	5	33	2	PS51081
Domain	Laminin_EGF	LAMA2 LAMB2 LAMC3	3.16e-05	35	33	3	PF00053
Domain	EGF_Lam	LAMA2 LAMB2 LAMC3	3.16e-05	35	33	3	SM00180
Domain	Laminin_EGF	LAMA2 LAMB2 LAMC3	4.06e-05	38	33	3	IPR002049
Domain	LAMININ_IVA	LAMA2 LAMC3	8.42e-05	8	33	2	PS51115
Domain	Laminin_B	LAMA2 LAMC3	8.42e-05	8	33	2	PF00052
Domain	LamB	LAMA2 LAMC3	8.42e-05	8	33	2	SM00281
Domain	Laminin_IV	LAMA2 LAMC3	8.42e-05	8	33	2	IPR000034
Domain	-	RNF14 SIAH1 SIAH2 CHD4 KAT6B RBCK1	1.19e-04	449	33	6	3.30.40.10
Domain	ZF_RING_1	RNF14 SIAH1 SIAH2 TRIM42 RBCK1	1.47e-04	291	33	5	PS00518
Domain	ZF_RING_2	RNF14 SIAH1 SIAH2 TRIM42 RBCK1	1.65e-04	298	33	5	PS50089
Domain	IBR	RNF14 RBCK1	2.72e-04	14	33	2	PF01485
Domain	ZP_1	TECTA ZPLD1	2.72e-04	14	33	2	PS00682
Domain	-	SIAH1 SIAH2	2.72e-04	14	33	2	3.90.890.10
Domain	-	SIAH1 SIAH2	2.72e-04	14	33	2	2.60.210.10
Domain	TIL_dom	LRP2 TECTA	2.72e-04	14	33	2	IPR002919
Domain	ZP_2	TECTA ZPLD1	2.72e-04	14	33	2	PS51034
Domain	IBR_dom	RNF14 RBCK1	3.13e-04	15	33	2	IPR002867
Domain	ZP	TECTA ZPLD1	3.13e-04	15	33	2	SM00241
Domain	SIAH-type	SIAH1 SIAH2	3.58e-04	16	33	2	IPR013323
Domain	ZP_dom	TECTA ZPLD1	4.05e-04	17	33	2	IPR001507
Domain	Zona_pellucida	TECTA ZPLD1	4.05e-04	17	33	2	PF00100
Domain	Galactose-bd-like	LAMA2 LAMB2 LAMC3	6.04e-04	94	33	3	IPR008979
Domain	EGF_3	LRP2 C7 TENM4 NOTCH2	7.51e-04	235	33	4	PS50026
Domain	TRAF-like	SIAH1 SIAH2	8.15e-04	24	33	2	IPR008974
Domain	EGF	LRP2 TECTA NOTCH2	1.41e-03	126	33	3	PF00008
Domain	-	LRP2 TENM4	2.15e-03	39	33	2	2.120.10.30
Domain	LDLR_class-A_CS	LRP2 C7	2.26e-03	40	33	2	IPR023415
Domain	Ldl_recept_a	LRP2 C7	2.86e-03	45	33	2	PF00057
Domain	Znf_RING_CS	RNF14 TRIM42 RBCK1	2.94e-03	163	33	3	IPR017907
Domain	-	LRP2 C7	2.98e-03	46	33	2	4.10.400.10
Domain	6-blade_b-propeller_TolB-like	LRP2 TENM4	2.98e-03	46	33	2	IPR011042
Domain	LDLRA_1	LRP2 C7	3.25e-03	48	33	2	PS01209
Domain	LDrepeatLR_classA_rpt	LRP2 C7	3.38e-03	49	33	2	IPR002172
Domain	LDLa	LRP2 C7	3.38e-03	49	33	2	SM00192
Domain	LDLRA_2	LRP2 C7	3.38e-03	49	33	2	PS50068
Domain	EGF_extracell	LRP2 TENM4	5.03e-03	60	33	2	IPR013111
Domain	EGF_2	LRP2 TENM4	5.03e-03	60	33	2	PF07974
Pathway	PID_A6B1_A6B4_INTEGRIN_PATHWAY	LAMA2 LAMB2 LAMC3 ERBB3	4.63e-07	46	20	4	M239
Pathway	REACTOME_MET_ACTIVATES_PTK2_SIGNALING	LAMA2 LAMB2 LAMC3	9.68e-06	30	20	3	M27772
Pathway	REACTOME_LAMININ_INTERACTIONS	LAMA2 LAMB2 LAMC3	9.68e-06	30	20	3	M27216
Pathway	REACTOME_MET_PROMOTES_CELL_MOTILITY	LAMA2 LAMB2 LAMC3	2.52e-05	41	20	3	M27778
Pathway	REACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS	LAMA2 LAMB2 LAMC3	7.55e-05	59	20	3	M27218
Pathway	PID_INTEGRIN4_PATHWAY	LAMA2 LAMB2	1.04e-04	11	20	2	M158
Pathway	REACTOME_SIGNALING_BY_MET	LAMA2 LAMB2 LAMC3	1.80e-04	79	20	3	M27643
Pathway	KEGG_SMALL_CELL_LUNG_CANCER	LAMA2 LAMB2 LAMC3	2.16e-04	84	20	3	M3228
Pathway	KEGG_ECM_RECEPTOR_INTERACTION	LAMA2 LAMB2 LAMC3	2.16e-04	84	20	3	M7098
Pathway	WP_SMALL_CELL_LUNG_CANCER	LAMA2 LAMB2 LAMC3	3.21e-04	96	20	3	M39834
Pathway	WP_CANCER_PATHWAYS	LAMA2 LAMB2 LAMC3 ADCY9 NOTCH2	5.84e-04	507	20	5	M48302
Pathway	REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES	LAMA2 LAMB2 LAMC3 ERBB3 CHD4	7.27e-04	532	20	5	M27870
Pathway	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	RNF14 SIAH1 SIAH2 RBCK1	7.35e-04	299	20	4	MM15711
Pathway	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	RNF14 SIAH1 SIAH2 RBCK1	8.21e-04	308	20	4	M1070
Pathway	WP_ALPHA_6_BETA_4_SIGNALING	LAMA2 LAMB2	9.83e-04	33	20	2	M39503
Pathway	REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION	RNF14 SIAH1 SIAH2 RBCK1	1.23e-03	343	20	4	MM15712
Pathway	WP_GENES_CONTROLLING_NEPHROGENESIS	LAMB2 NOTCH2	1.75e-03	44	20	2	M39891
Pathway	REACTOME_NETRIN_1_SIGNALING	SIAH1 SIAH2	1.75e-03	44	20	2	M875
Pathway	REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION	RNF14 SIAH1 SIAH2 RBCK1	1.81e-03	381	20	4	M1066
Pathway	WP_FOCAL_ADHESION	LAMA2 LAMB2 LAMC3	2.22e-03	187	20	3	MM15913
Pathway	WP_FOCAL_ADHESION	LAMA2 LAMB2 LAMC3	2.65e-03	199	20	3	M39402
Pathway	KEGG_FOCAL_ADHESION	LAMA2 LAMB2 LAMC3	2.65e-03	199	20	3	M7253
Pubmed	The extracellular-matrix protein matrilin 2 participates in peripheral nerve regeneration.	LAMA2 LAMB2 ERBB3	6.51e-08	9	33	3	19295126
Pubmed	Regional differences in the expression of laminin isoforms during mouse neural tube development.	LAMA2 LAMB2 LAMC3	1.28e-07	11	33	3	21524702
Pubmed	Mutations in LAMB1 cause cobblestone brain malformation without muscular or ocular abnormalities.	LAMA2 LAMB2 LAMC3	1.28e-07	11	33	3	23472759
Pubmed	Wnt5a Deficiency Leads to Anomalies in Ureteric Tree Development, Tubular Epithelial Cell Organization and Basement Membrane Integrity Pointing to a Role in Kidney Collecting Duct Patterning.	LAMA2 LAMB2 LAMC3	1.70e-07	12	33	3	26794322
Pubmed	Basement membrane composition in the early mouse embryo day 7.	LAMA2 LAMB2 LAMC3	3.51e-07	15	33	3	15895400
Pubmed	Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling.	LAMA2 LAMB2 LAMC3	4.32e-07	16	33	3	17601529
Pubmed	Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53.	LAMA2 LAMB2 LAMC3	6.29e-07	18	33	3	11311202
Pubmed	Inhibition of Siah ubiquitin ligase function.	SIAH1 SIAH2	8.73e-07	2	33	2	18850011
Pubmed	Laminins containing the β2 and γ3 chains regulate astrocyte migration and angiogenesis in the retina.	LAMB2 LAMC3	8.73e-07	2	33	2	23571221
Pubmed	Fine tuning of the UPR by the ubiquitin ligases Siah1/2.	SIAH1 SIAH2	8.73e-07	2	33	2	24809345
Pubmed	Defective formation of the inner limiting membrane in laminin beta2- and gamma3-null mice produces retinal dysplasia.	LAMB2 LAMC3	8.73e-07	2	33	2	19907020
Pubmed	Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina).	SIAH1 SIAH2	8.73e-07	2	33	2	8404535
Pubmed	Generation and analysis of Siah2 mutant mice.	SIAH1 SIAH2	8.73e-07	2	33	2	14645526
Pubmed	Characterization of human homologs of the Drosophila seven in absentia (sina) gene.	SIAH1 SIAH2	8.73e-07	2	33	2	9403064
Pubmed	β2 and γ3 laminins are critical cortical basement membrane components: ablation of Lamb2 and Lamc3 genes disrupts cortical lamination and produces dysplasia.	LAMB2 LAMC3	8.73e-07	2	33	2	22961762
Pubmed	SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status.	SIAH1 SIAH2	8.73e-07	2	33	2	26654769
Pubmed	Cellular and axonal constituents of neocortical molecular layer heterotopia.	LAMB2 LAMC3	8.73e-07	2	33	2	25247689
Pubmed	Laminin-Dependent Interaction between Astrocytes and Microglia: A Role in Retinal Angiogenesis.	LAMB2 LAMC3	8.73e-07	2	33	2	28697326
Pubmed	Dimerization of hSiah proteins regulates their stability.	SIAH1 SIAH2	8.73e-07	2	33	2	16899216
Pubmed	Laminin deficits induce alterations in the development of dopaminergic neurons in the mouse retina.	LAMB2 LAMC3	8.73e-07	2	33	2	17711601
Pubmed	Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: implications for regulation of BMP signalling.	LAMA2 LAMB2 LAMC3	8.77e-07	20	33	3	22911573
Pubmed	Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins.	LAMA2 LAMB2 LAMC3	1.99e-06	26	33	3	24742657
Pubmed	The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome.	SIAH1 SIAH2	2.62e-06	3	33	2	14645235
Pubmed	Normal p53 function in primary cells deficient for Siah genes.	SIAH1 SIAH2	2.62e-06	3	33	2	12417719
Pubmed	The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice.	SIAH1 SIAH2	2.62e-06	3	33	2	11884614
Pubmed	Laminin isoforms in development and disease.	LAMA2 LAMB2	2.62e-06	3	33	2	17426950
Pubmed	The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear.	SIAH1 SIAH2	2.62e-06	3	33	2	27776223
Pubmed	Characterization and expression of the laminin gamma3 chain: a novel, non-basement membrane-associated, laminin chain.	LAMA2 LAMC3	2.62e-06	3	33	2	10225960
Pubmed	Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage Functions to Limit Carcinogen-Induced Lung Adenocarcinoma.	SIAH1 SIAH2	2.62e-06	3	33	2	37078793
Pubmed	Investigating the molecular basis of Siah1 and Siah2 E3 ubiquitin ligase substrate specificity.	SIAH1 SIAH2	2.62e-06	3	33	2	25202994
Pubmed	An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response.	SIAH1 SIAH2	2.62e-06	3	33	2	19043406
Pubmed	Siah proteins induce the epidermal growth factor-dependent degradation of phospholipase Cepsilon.	SIAH1 SIAH2	2.62e-06	3	33	2	17998205
Pubmed	The ubiquitin ligase Siah is a novel regulator of Zeb1 in breast cancer.	SIAH1 SIAH2	2.62e-06	3	33	2	25528765
Pubmed	Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1.	SIAH1 SIAH2	2.62e-06	3	33	2	12810624
Pubmed	Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis.	SIAH1 SIAH2	2.62e-06	3	33	2	10681424
Pubmed	Central role of SIAH inhibition in DCC-dependent cardioprotection provoked by netrin-1/NO.	SIAH1 SIAH2	2.62e-06	3	33	2	25561546
Pubmed	Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit.	SIAH1 SIAH2	2.62e-06	3	33	2	21109632
Pubmed	Interaction of AF4 wild-type and AF4.MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology?	SIAH1 SIAH2	5.23e-06	4	33	2	15221006
Pubmed	Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia.	SIAH1 SIAH2	5.23e-06	4	33	2	22099302
Pubmed	Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells.	SIAH1 SIAH2	5.23e-06	4	33	2	18070888
Pubmed	SIAH proteins regulate the degradation and intra-mitochondrial aggregation of PINK1: Implications for mitochondrial pathology in Parkinson's disease.	SIAH1 SIAH2	5.23e-06	4	33	2	36307912
Pubmed	Distribution and isolation of four laminin variants; tissue restricted distribution of heterotrimers assembled from five different subunits.	LAMA2 LAMB2	5.23e-06	4	33	2	2099832
Pubmed	Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1α (HIF-1α) during hypoxia.	SIAH1 SIAH2	5.23e-06	4	33	2	22128162
Pubmed	Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins.	SIAH1 SIAH2	5.23e-06	4	33	2	9858595
Pubmed	Human colonic cancer cells synthesize and adhere to laminin-5. Their adhesion to laminin-5 involves multiple receptors among which is integrin alpha2beta1.	LAMB2 LAMC3	5.23e-06	4	33	2	9645947
Pubmed	Siah-1 is associated with expression of hypoxia-inducible factor-1α in oral squamous cell carcinoma.	SIAH1 SIAH2	5.23e-06	4	33	2	27616748
Pubmed	P-TEFb is degraded by Siah1/2 in quiescent cells.	SIAH1 SIAH2	5.23e-06	4	33	2	35524561
Pubmed	Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease.	SIAH1 SIAH2	5.23e-06	4	33	2	15064394
Pubmed	Genetic deletion of laminin isoforms β2 and γ3 induces a reduction in Kir4.1 and aquaporin-4 expression and function in the retina.	LAMB2 LAMC3	5.23e-06	4	33	2	21283711
Pubmed	Regulation of BOB.1/OBF.1 stability by SIAH.	SIAH1 SIAH2	5.23e-06	4	33	2	11483518
Pubmed	Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway.	SIAH1 SIAH2	5.23e-06	4	33	2	9334332
Pubmed	Properly formed but improperly localized synaptic specializations in the absence of laminin alpha4.	LAMA2 LAMB2	8.72e-06	5	33	2	11369940
Pubmed	hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways.	SIAH1 SIAH2	8.72e-06	5	33	2	10207103
Pubmed	The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation.	SIAH1 SIAH2	8.72e-06	5	33	2	28546513
Pubmed	Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation.	SIAH1 SIAH2	8.72e-06	5	33	2	19224863
Pubmed	Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesis.	LAMB2 LAMC3	8.72e-06	5	33	2	16581764
Pubmed	SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway.	SIAH1 SIAH2	8.72e-06	5	33	2	14654780
Pubmed	Regulation of melanoma cell migration and invasion by laminin-5 and alpha3beta1 integrin (VLA-3).	LAMB2 LAMC3	8.72e-06	5	33	2	11964076
Pubmed	Regulation of synaptophysin degradation by mammalian homologues of seven in absentia.	SIAH1 SIAH2	8.72e-06	5	33	2	11786535
Pubmed	Cross-linking of laminin-nidogen complexes by tissue transglutaminase. A novel mechanism for basement membrane stabilization.	LAMA2 LAMB2	1.31e-05	6	33	2	1678389
Pubmed	Structural elucidation of full-length nidogen and the laminin-nidogen complex in solution.	LAMA2 LAMB2	1.31e-05	6	33	2	23948589
Pubmed	A synaptic nidogen: developmental regulation and role of nidogen-2 at the neuromuscular junction.	LAMA2 LAMB2	1.31e-05	6	33	2	18817539
Pubmed	Entactin: structure and function.	LAMA2 LAMB2	1.31e-05	6	33	2	2119632
Pubmed	SIAH ubiquitin ligases target the nonreceptor tyrosine kinase ACK1 for ubiquitinylation and proteasomal degradation.	SIAH1 SIAH2	1.31e-05	6	33	2	23208506
Pubmed	Impaired primary mouse myotube formation on crosslinked type I collagen films is enhanced by laminin and entactin.	LAMA2 LAMB2	1.31e-05	6	33	2	26555376
Pubmed	Effect of basement membrane entactin on epidermal cell attachment and growth.	LAMA2 LAMB2	1.31e-05	6	33	2	3794389
Pubmed	Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia.	SIAH1 SIAH2	1.31e-05	6	33	2	15210114
Pubmed	Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation.	SIAH1 SIAH2	1.31e-05	6	33	2	16174773
Pubmed	Laminin-nidogen complex. Extraction with chelating agents and structural characterization.	LAMA2 LAMB2	1.31e-05	6	33	2	3109910
Pubmed	Laminins promote the locomotion of skeletal myoblasts via the alpha 7 integrin receptor.	LAMA2 LAMB2	1.83e-05	7	33	2	9004048
Pubmed	A new nomenclature for the laminins.	LAMB2 LAMC3	1.83e-05	7	33	2	7921537
Pubmed	Laminin isoforms in fetal and adult human adrenal cortex.	LAMA2 LAMB2	1.83e-05	7	33	2	14557481
Pubmed	Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.	SIAH1 SIAH2	2.44e-05	8	33	2	11389839
Pubmed	Differential regulation of PML-RARα stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1.	SIAH1 SIAH2	2.44e-05	8	33	2	22037423
Pubmed	ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration.	LRP2 ERBB3	2.44e-05	8	33	2	18426980
Pubmed	A crosstalk between hSiah2 and Pias E3-ligases modulates Pias-dependent activation.	SIAH1 SIAH2	3.13e-05	9	33	2	17533377
Pubmed	Distribution of the ten known laminin chains in the pathways and targets of developing sensory axons.	LAMA2 LAMB2	3.91e-05	10	33	2	9034910
Pubmed	An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19.	SIAH1 SIAH2	3.91e-05	10	33	2	23500468
Pubmed	Trophoblast-specific expression and function of the integrin alpha 7 subunit in the peri-implantation mouse embryo.	LAMA2 LAMC3	3.91e-05	10	33	2	11784026
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	LRP2 LAMA2 TENM4	4.26e-05	71	33	3	33541421
Pubmed	Small heterodimer partner SHP mediates liver X receptor (LXR)-dependent suppression of inflammatory signaling by promoting LXR SUMOylation specifically in astrocytes.	SIAH1 SIAH2	4.78e-05	11	33	2	27485016
Pubmed	Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice.	LAMA2 LAMB2	5.73e-05	12	33	2	9396756
Pubmed	Transcriptome-based systematic identification of extracellular matrix proteins.	LAMA2 LAMB2 LAMC3	5.86e-05	79	33	3	18757743
Pubmed	The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut.	LAMA2 LAMB2	6.77e-05	13	33	2	36350252
Pubmed	Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.	SIAH1 SIAH2 RBCK1	7.29e-05	85	33	3	19028597
Pubmed	Laminin alpha5 chain is required for intestinal smooth muscle development.	LAMA2 LAMB2	9.10e-05	15	33	2	12921739
Pubmed	MOR is not enough: identification of novel mu-opioid receptor interacting proteins using traditional and modified membrane yeast two-hybrid screens.	SIAH1 SIAH2	9.10e-05	15	33	2	23840749
Pubmed	Patterns of laminins and integrins in the embryonic ventricular zone of the CNS.	LAMA2 LAMB2	1.04e-04	16	33	2	17948866
Pubmed	Beta1-integrins are critical for cerebellar granule cell precursor proliferation.	LAMA2 LAMB2	1.18e-04	17	33	2	15056720
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	LRP2 ERBB3 NOTCH2	1.22e-04	101	33	3	23382219
Pubmed	Defective neuromuscular synaptogenesis in agrin-deficient mutant mice.	LAMB2 ERBB3	1.32e-04	18	33	2	8653788
Pubmed	Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.	RNF14 SIAH1 RBCK1	1.37e-04	105	33	3	22493164
Pubmed	Barx2 and Fgf10 regulate ocular glands branching morphogenesis by controlling extracellular matrix remodeling.	LAMA2 LAMB2	1.64e-04	20	33	2	21750040
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	LRP2 SIAH1 ERBB3 CHD4 POGZ ZNF565 RBCK1	1.70e-04	1285	33	7	35914814
Pubmed	Schwann cell myelination requires integration of laminin activities.	LAMA2 LAMC3	1.81e-04	21	33	2	22767514
Pubmed	Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders.	LAMA2 LAMC3	1.99e-04	22	33	2	35245678
Pubmed	Chromosomal mapping of five highly conserved murine homologues of the Drosophila RING finger gene seven-in-absentia.	SIAH1 SIAH2	2.18e-04	23	33	2	9143490
Pubmed	Functional proteomics mapping of a human signaling pathway.	RNF14 LAMB2 SIAH1 SIAH2 NOTCH2	2.23e-04	591	33	5	15231748
Pubmed	Analysis of the human HP1 interactome reveals novel binding partners.	CHD4 POGZ	3.49e-04	29	33	2	21888893
Pubmed	Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.	LAMA2 LAMB2	3.49e-04	29	33	2	22613833
Interaction	ATN1 interactions	LRP2 HINFP SIAH1 SIAH2 KAT6B	1.25e-05	187	33	5	int:ATN1
Interaction	DAB1 interactions	LRP2 SIAH1 ERBB3 POGZ	2.73e-05	107	33	4	int:DAB1
Cytoband	Ensembl 112 genes in cytogenetic band chr11q23	HINFP NXPE2 TECTA	5.33e-04	220	33	3	chr11q23
Cytoband	11q23.3	HINFP NXPE2	1.45e-03	78	33	2	11q23.3
Cytoband	Ensembl 112 genes in cytogenetic band chr6q22	LAMA2 ZUP1	3.79e-03	127	33	2	chr6q22
GeneFamily	Laminin subunits	LAMA2 LAMB2 LAMC3	3.42e-07	12	22	3	626
GeneFamily	Ring finger proteins	RNF14 TRIM42 RBCK1	4.33e-03	275	22	3	58
GeneFamily	PHD finger proteins	CHD4 KAT6B	5.31e-03	90	22	2	88
Coexpression	NABA_CORE_MATRISOME	LAMA2 KERA LAMB2 LAMC3 TECTA ZPLD1	9.91e-07	270	33	6	MM17057
Coexpression	NABA_CORE_MATRISOME	LAMA2 KERA LAMB2 LAMC3 TECTA ZPLD1	1.10e-06	275	33	6	M5884
Coexpression	NABA_ECM_GLYCOPROTEINS	LAMA2 LAMB2 LAMC3 TECTA ZPLD1	3.92e-06	191	33	5	MM17059
Coexpression	WEST_ADRENOCORTICAL_TUMOR_DN	LAMA2 LAMB2 LAMC3 ERBB3 CHD4 C7 KAT6B	4.37e-06	546	33	7	M3837
Coexpression	NABA_ECM_GLYCOPROTEINS	LAMA2 LAMB2 LAMC3 TECTA ZPLD1	4.45e-06	196	33	5	M3008
Coexpression	GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_60H_DN	RNF14 LAMB2 PTER ADAM7 NOTCH2	4.91e-06	200	33	5	M9657
Coexpression	NABA_BASEMENT_MEMBRANES	LAMA2 LAMB2 LAMC3	1.74e-05	40	33	3	M5887
Coexpression	NABA_MATRISOME	LAMA2 KERA LAMB2 LAMC3 SERPINB9 TECTA ZPLD1 ADAM7	2.74e-05	1008	33	8	MM17056
Coexpression	NABA_MATRISOME	LAMA2 KERA LAMB2 LAMC3 SERPINB9 TECTA ZPLD1 ADAM7	3.11e-05	1026	33	8	M5889
Coexpression	GSE17721_LPS_VS_PAM3CSK4_6H_BMDC_UP	RNF14 SERPINB9 ZUP1 NOTCH2	1.11e-04	199	33	4	M3918
Coexpression	GSE19888_ADENOSINE_A3R_INH_VS_TCELL_MEMBRANES_ACT_MAST_CELL_UP	HINFP SERPINB9 USP27X ZUP1	1.13e-04	200	33	4	M7324
Coexpression	GSE15330_LYMPHOID_MULTIPOTENT_VS_PRO_BCELL_DN	C9orf85 RNF14 SERPINB9 TECTA	1.13e-04	200	33	4	M7016
Coexpression	STEIN_ESTROGEN_RESPONSE_NOT_VIA_ESRRA	SIAH2 ADCY9	2.32e-04	18	33	2	M8583
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KERA LAMB2 LAMC3 ZPLD1	1.01e-05	184	33	4	94748f63947db79a6b4540e3090a63689fdd9452
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KERA LAMB2 LAMC3 ZPLD1	1.01e-05	184	33	4	819b277ecced7b415e363c7e7ddbc6f3b2d296de
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7 NOTCH2	1.15e-05	190	33	4	1121eb607a984c59fbffe7220837fc178745aa55
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7 NOTCH2	1.15e-05	190	33	4	048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCell	COVID-19-Heart-Fib_2\|Heart / Disease (COVID-19 only), tissue and cell type	LAMA2 C7 TENM4 NOTCH2	1.24e-05	194	33	4	d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCell	COVID-19-Heart-Fib_1\|Heart / Disease (COVID-19 only), tissue and cell type	LAMA2 C7 TENM4 NOTCH2	1.27e-05	195	33	4	f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCell	PCW_05-06-Mesenchymal\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	LAMA2 C7 TENM4 NOTCH2	1.29e-05	196	33	4	dca52c57ba35d9395cdbca8b881f12ece721b10f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7 NOTCH2	1.35e-05	198	33	4	a860246bcea847249a78fd2e86ed8e04371060db
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-C1ql2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TRIM42 PTER ZPLD1	8.18e-05	114	33	3	f48fd7d378626eb7ef972ff1df87dd6149cb355c
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast-MyoFB-3\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	LAMA2 LAMC3 TRIM42	1.35e-04	135	33	3	5b13ff740d9f7d96274aebb6b389a80f6004adc7
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	1.63e-04	144	33	3	cf9f049ab6cd80521598124f057c2debdde24788
ToppCell	LPS-antiTNF-Myeloid-Monocytes,_Macrophages-Erythroid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LRP2 C7 PLAC8L1	1.63e-04	144	33	3	1b9e95e4f6e40042d3cf2f94c067f3a6b19428ea
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_104\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	1.63e-04	144	33	3	41eaeca54b3c39de417597267cbdb1f195dd885a
ToppCell	normal_Pleural_Fluid-Myeloid_cells-Monocytes\|Myeloid_cells / Location, Cell class and cell subclass	HINFP USP27X ZUP1	2.03e-04	155	33	3	85eb60d285b8bfc095c341ae90c0e3b7e7dca9c1
ToppCell	5'-Adult-Appendix-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERBB3 NXPE2 NOTCH2	2.03e-04	155	33	3	5fabe24a784f0be46040ffc886eabd8d5ce78121
ToppCell	primary_visual_cortex-Non-neuronal-pericyte_cell-Peri\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LAMA2 LAMB2 LAMC3	2.03e-04	155	33	3	d8b5145258f075b15080f8739f537f48dd22225e
ToppCell	primary_visual_cortex-Non-neuronal-pericyte_cell-Peri-Peri_Kcnj8\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LAMA2 LAMB2 LAMC3	2.03e-04	155	33	3	ced64e26962c5c6e6d539f361fe57ab0b399e999
ToppCell	primary_visual_cortex-Non-neuronal-pericyte_cell\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LAMA2 LAMB2 LAMC3	2.03e-04	155	33	3	0f24ef6486aef354f0911c06932cb01d1a0525ac
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMC3 C7 TENM4	2.11e-04	157	33	3	beab0ac47202266b04543c02cfcdda012375e879
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 LAMA2 TECTA	2.23e-04	160	33	3	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 LAMA2 TECTA	2.23e-04	160	33	3	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	LAMB2 ERBB3 TRMT1L	2.27e-04	161	33	3	58381131e651744b5141b202f9d6063f55432db5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 C7 MTAP	2.31e-04	162	33	3	bfaeff19bb56598fdc8c82be71d51787cf13928f
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Alveolar_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	C7 TENM4 PTER	2.48e-04	166	33	3	65dafed953b01a9830b54309af75c7a561e88336
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMA2 LAMC3 C7	2.57e-04	168	33	3	d2b91f2adc95dcfa623f8d7ca2df1c6f884da988
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	2.57e-04	168	33	3	d19a115365c5415e51c039718d7669de788fcf33
ToppCell	droplet-Pancreas-Exocrine-18m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 LAMC3 NOTCH2	2.61e-04	169	33	3	53690d6f9712b54aa99a0408aae930d64ae478e5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	2.61e-04	169	33	3	a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LAMB2 LAMC3 NOTCH2	2.71e-04	171	33	3	2e43fb129ee9bdc3b31febc43c10f959bf0f4a7d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	2.71e-04	171	33	3	972fab891135bd755d5526cbc5a963200067b0a6
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 LAMC3 NOTCH2	2.71e-04	171	33	3	5447b78148f7bccb727e2fc108589b2af02a5d31
ToppCell	droplet-Pancreas-Exocrine\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 LAMC3 NOTCH2	2.71e-04	171	33	3	92ac4cc3d54da2ea8e202aa59c78e8875356649e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	2.71e-04	171	33	3	2a77ed79c6f2e700e789c80451a70ecb31639719
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LAMB2 LAMC3 NOTCH2	2.71e-04	171	33	3	e219a1aa59a96e4bc3e2eacf985679174a51de41
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_ductal_cel\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 LAMC3 NOTCH2	2.75e-04	172	33	3	a7eee0a30d2fe20c865a07b9004c6a821a72c0c4
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	2.75e-04	172	33	3	1ef243bce63d841c25e4b74d029d1377f84bcc3d
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	2.75e-04	172	33	3	ab1c81be29f93ca8920c6ab5ab92f497a9256d3f
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 LAMC3 NOTCH2	2.75e-04	172	33	3	0a9fe2cd28203970295a1288078c66eadac1c9ed
ToppCell	-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	LAMA2 LAMC3 C7	2.80e-04	173	33	3	88be9182fbb1bc83531cd41e59ea57c112a21d54
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	2.80e-04	173	33	3	ab6d3507301038f944ad59ccd848b5e6eeb76d04
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C9orf85 SMIM14 NOTCH2	2.85e-04	174	33	3	01eff218e71a04201189a0313aaf91437fffed95
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C9orf85 SMIM14 NOTCH2	2.85e-04	174	33	3	f0f6d135e1fb4c15022be103b00d8d5456515a18
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 C7 NOTCH2	2.85e-04	174	33	3	9c916af5eebd932f67dc9117e1d26ff194a2ff2c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 C7 NOTCH2	2.85e-04	174	33	3	bc71521f44a5fe013af42b06b5d1bd2446ecf3b5
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C9orf85 SMIM14 NOTCH2	2.85e-04	174	33	3	2f4bc0275cbcaa830d04a4c76e042456908d2277
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LAMC3 C7 NOTCH2	2.90e-04	175	33	3	f0c2eb82e17e8aec2cfa5d83169178f409cc1abc
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-stromal_related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMA2 C7 USP27X	2.90e-04	175	33	3	b8995e7ada85ba959f06264a0295b61e390c4e6c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LAMC3 C7 NOTCH2	2.90e-04	175	33	3	910a075ccaf79de22338ecf321fa0a867f3d7d75
ToppCell	facs-Marrow-B-cells-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 LAMA2 C7	2.90e-04	175	33	3	887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-stromal_related-T_reticular\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMA2 C7 USP27X	2.90e-04	175	33	3	7ae76bd3b4f610b2f98716a4456437cd3696b686
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	LAMA2 KERA C7	2.95e-04	176	33	3	510f9a14dc1c151d24d079e0cc004cdf4f86336c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 MTAP	2.95e-04	176	33	3	9bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 MTAP	2.95e-04	176	33	3	3f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	C7 TENM4 NOTCH2	2.99e-04	177	33	3	7af1a19692f7fe8f691178a4e57d62bc379e3d56
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	3.04e-04	178	33	3	d4ecb84e9b1f4ec49c519321156aa10f9bd34cce
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	3.04e-04	178	33	3	78a0c6340001a77f5b2d890b6263f574af2e72da
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype\|TCGA-Lung / Sample_Type by Project: Shred V9	ERBB3 SMIM14 PTER	3.20e-04	181	33	3	c783c2ecca7ab8e07646fa92dc7d436d24939d03
ToppCell	5'-Adult-LymphNode-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMA2 C7 TENM4	3.20e-04	181	33	3	ab66a89f316b935d9ba1277426d976b1e9e39757
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	3.20e-04	181	33	3	c62b0a2422377ffadaab63edd538e87a06fa5017
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	3.20e-04	181	33	3	c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	3.25e-04	182	33	3	44764676ed3f51ba171ce63f669390392fa50a43
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	3.25e-04	182	33	3	af65f0fc3f9e5d9ce69ee5faaf5b6cb7f8412e0c
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMA2 KERA C7	3.25e-04	182	33	3	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	3.25e-04	182	33	3	d82f59a3f930a840dde27dc6ab024f227a26d446
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	3.25e-04	182	33	3	b7d532feb73167e05475855061b35a209583f44c
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KERA LAMB2 ZPLD1	3.25e-04	182	33	3	ffe500d78a89dc6b4d05bab1664e7f30c94fb8d9
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LAMA2 C7 TENM4	3.25e-04	182	33	3	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMA2 C7 TENM4	3.30e-04	183	33	3	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	3.35e-04	184	33	3	c5436a8e45f471b8d1301abbe9c7879204537f52
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRP2 TENM4 PTER	3.35e-04	184	33	3	9434731f651820b05335085582960f08fbf895de
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	LAMA2 C7 TENM4	3.41e-04	185	33	3	9f19f04fc4d97dfc2dd78cde77b515f1cb5d51ec
ToppCell	facs-Skin-nan-24m-Mesenchymal\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA2 LAMC3 C7	3.41e-04	185	33	3	8433a337625ff8398520e223ef92bf9bb0beb14c
ToppCell	COVID-19-Heart-Fib_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LAMA2 C7 TENM4	3.41e-04	185	33	3	8f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCell	facs-Skin-nan-24m-Mesenchymal-fibroblast\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA2 LAMC3 C7	3.41e-04	185	33	3	049d793d043d5d434f143025de49dd210d18756c
ToppCell	facs-Skin-nan-24m-Mesenchymal-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA2 LAMC3 C7	3.41e-04	185	33	3	63200c42565eea596f9b00728e70e544b8d50a7f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LRP2 TENM4 PTER	3.46e-04	186	33	3	b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	LAMA2 C7 TENM4	3.52e-04	187	33	3	13731298bc562ec29582f5da1b4c97261284f6f1
ToppCell	Control-Fibroblasts-Other_FB\|Control / group, cell type (main and fine annotations)	LAMA2 C7 TENM4	3.52e-04	187	33	3	bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-6\|TCGA-Breast / Sample_Type by Project: Shred V9	LAMA2 KERA TENM4	3.52e-04	187	33	3	a96495803ba13fcfadd1d83b3cf5774f3fed0a20
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6\|TCGA-Breast / Sample_Type by Project: Shred V9	LAMA2 KERA C7	3.57e-04	188	33	3	c90669b51e1902fe7726555290c91c92a911df83
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 ERBB3 NOTCH2	3.57e-04	188	33	3	842982de2197770f999a70083ed9fca40ac22d79
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB2 ERBB3 NOTCH2	3.57e-04	188	33	3	a0815eaf68eedd6e5ec4af520df80a6ab4eb0864
ToppCell	-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	LAMA2 LAMC3 C7	3.57e-04	188	33	3	038f48e8daaeb72716e975d22a6b004a90654960
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LAMA2 MTAP ADCY9	3.57e-04	188	33	3	a906c29e3fda22eecfec3e5cac706c417bf2b7a4
ToppCell	COVID-19-Heart-Fib_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LAMA2 C7 TENM4	3.57e-04	188	33	3	fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCell	Substantia_nigra-Endothelial\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	LAMB2 LAMC3 SERPINB9	3.63e-04	189	33	3	bef8234bd9c4d6e3cdef0791d8066b39ba56ebba
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	3.63e-04	189	33	3	71397e993a77d70b2eeede240bdfc7660b558987
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMA2 KERA C7	3.63e-04	189	33	3	f7d57723b8fb0f1e1485f51e3eff93ec0f39761e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	3.63e-04	189	33	3	4eea4759520c312bd17a681034d8074e47093d2b
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LAMA2 MTAP ADCY9	3.68e-04	190	33	3	951e067d14412db67dc3babcdf61e41717d7b429
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	3.68e-04	190	33	3	70c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	3.68e-04	190	33	3	1f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	3.68e-04	190	33	3	2306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LAMA2 LAMC3 NOTCH2	3.68e-04	190	33	3	106862ef44fcaa0971c3ba0147d13eb08015ca77
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	3.74e-04	191	33	3	39092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	3.74e-04	191	33	3	a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 LAMC3 C7	3.74e-04	191	33	3	107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 SERPINB9 C7	3.74e-04	191	33	3	a6c57627077fa980b7ec1d3894b5f31bfb11b738
ToppCell	ASK454-Mesenchymal-Fibroblast\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	LAMA2 LAMC3 C7	3.74e-04	191	33	3	1726add3f392a061536b7aff72ba84303f4a0b1f
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	C7 TENM4 NOTCH2	3.74e-04	191	33	3	14057205ddb9b4bbc582d1358d13cf36d979a61b
Drug	AC1L1G72	LAMA2 LAMB2 LAMC3	4.54e-07	11	33	3	CID000003553
Drug	LG 5	LAMA2 LAMB2 LAMC3 ERBB3	1.68e-06	60	33	4	CID011840957
Drug	2-amino-5-methylpyridine	LAMA2 LAMB2 LAMC3 ERBB3	4.59e-06	77	33	4	CID000015348
Drug	NSC 714187	LAMA2 LAMB2 LAMC3 ERBB3	6.82e-06	85	33	4	CID005288693
Drug	AC1L1B58	LAMA2 LAMB2 LAMC3	9.88e-06	29	33	3	CID000001288
Drug	Calcort	LAMA2 LAMB2 LAMC3	2.26e-05	38	33	3	CID000026709
Drug	isocycloheximide	LRP2 HINFP LAMA2 LAMB2 SIAH2 LAMC3 ERBB3 ADCY9	3.46e-05	905	33	8	CID000002900
Drug	LMWH	LRP2 LAMA2 KERA LAMB2 LAMC3 ERBB3 ADCY9	3.80e-05	663	33	7	CID000000772
Drug	kalinin	LAMA2 LAMB2 LAMC3	6.91e-05	55	33	3	CID000032518
Drug	I-Q-S	LAMA2 LAMB2 LAMC3 ADCY9	7.43e-05	156	33	4	CID000003540
Drug	1-(5-isoquinolinesulfonyl)-2-methylpiperazine	LAMA2 LAMB2 LAMC3 ERBB3 ADCY9	8.35e-05	314	33	5	CID000003542
Drug	CC270	LAMA2 LAMB2 LAMC3	8.53e-05	59	33	3	CID006918852
Drug	I-Br	RNF14 SIAH1 RBCK1	1.30e-04	68	33	3	CID005327193
Drug	ICI 182,780; Down 200; 1uM; MCF7; HT_HG-U133A	SIAH2 KAT6B ADCY9 NOTCH2	1.53e-04	188	33	4	1630_DN
Drug	dysprosium	LAMA2 LAMB2 LAMC3	1.68e-04	74	33	3	CID000023912
Drug	Butylparaben [94-26-8]; Up 200; 20.6uM; MCF7; HT_HG-U133A	KERA SERPINB9 ADCY9 ADAM7	1.76e-04	195	33	4	5608_UP
Drug	Debrisoquin sulfate [581-88-4]; Up 200; 9uM; MCF7; HT_HG-U133A	RNF14 KAT6B ADCY9 RBCK1	1.79e-04	196	33	4	5288_UP
Drug	Etodolac [41340-25-4]; Up 200; 14uM; MCF7; HT_HG-U133A	SIAH1 CHD4 POGZ RBCK1	1.86e-04	198	33	4	7006_UP
Drug	Cholecalciferol [67-97-0]; Up 200; 10.4uM; HL60; HT_HG-U133A	LRP2 LAMB2 SERPINB9 TECTA	1.86e-04	198	33	4	2436_UP
Drug	L(-)-vesamicol hydrochloride [112709-59-8]; Down 200; 13.6uM; MCF7; HT_HG-U133A	LRP2 SIAH1 POGZ NOTCH2	1.86e-04	198	33	4	5475_DN
Drug	Clofilium tosylate [92953-10-1]; Up 200; 7.8uM; PC3; HT_HG-U133A	LRP2 LAMA2 LAMC3 SERPINB9	1.86e-04	198	33	4	4492_UP
Drug	Canavanine sulfate monohydrate (L,+) [206996-57-8]; Up 200; 13.6uM; PC3; HT_HG-U133A	LRP2 LAMA2 SERPINB9 ADAM7	1.90e-04	199	33	4	4197_UP
Drug	GBR 12909 dihydrochloride [67469-78-7]; Down 200; 7.6uM; MCF7; HT_HG-U133A	LRP2 POGZ ADCY9 NOTCH2	1.94e-04	200	33	4	3240_DN
Drug	PHA-00745360 [351320-33-7]; Down 200; 1uM; PC3; HT_HG-U133A	LRP2 LAMA2 LAMC3 CHD4	1.94e-04	200	33	4	3827_DN
Disease	octadecanedioate measurement	LAMA2 LAMC3	5.10e-05	10	32	2	EFO_0021056
Disease	membranous glomerulonephritis (biomarker_via_orthology)	LRP2 C7	1.03e-04	14	32	2	DOID:10976 (biomarker_via_orthology)
Disease	Benign neoplasm of bladder	ERBB3 NOTCH2	1.19e-04	15	32	2	C0154017
Disease	Neoplasm of uncertain or unknown behavior of bladder	ERBB3 NOTCH2	1.19e-04	15	32	2	C0496930
Disease	Carcinoma in situ of bladder	ERBB3 NOTCH2	1.19e-04	15	32	2	C0154091
Disease	Carcinoma of bladder	ERBB3 NOTCH2	1.72e-04	18	32	2	C0699885
Disease	Schizophrenia	LRP2 LAMA2 ERBB3 CHD4 TENM4 ZNF565	3.29e-04	883	32	6	C0036341
Disease	lysophosphatidylethanolamine 16:0 measurement	NXPE2 ADCY9	3.64e-04	26	32	2	EFO_0010366
Disease	Child Development Disorders, Specific	LRP2 CHD4	4.54e-04	29	32	2	C0085997
Disease	Child Development Deviations	LRP2 CHD4	4.54e-04	29	32	2	C0085996
Disease	Bladder Neoplasm	LAMA2 ERBB3 NOTCH2	4.69e-04	140	32	3	C0005695
Disease	Malignant neoplasm of urinary bladder	LAMA2 ERBB3 NOTCH2	4.79e-04	141	32	3	C0005684
Disease	Developmental Disabilities	LRP2 CHD4	4.86e-04	30	32	2	C0008073
Disease	intestinal cancer (implicated_via_orthology)	ERBB3 NOTCH2	5.54e-04	32	32	2	DOID:10155 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
EAECFSCHPECQPME	ERBB3	546	P21860
ECDFPEMCTGHSPAC	ADAM7	466	Q9H2U9
CARGVCHIPMAEPFC	MTAP	131	Q13126
CDRGFHMECCDPPLS	KAT6B	291	Q8WYB5
PRCEMDINECHSDPC	NOTCH2	451	Q04721
PGCEMCCRARPEAYQ	RBCK1	211	Q9BYM8
LRDPAVCRSCDCDPM	LAMB2	401	P55268
MCICYGHARACPLDP	LAMA2	286	P24043
RDCEMRTCHPEYFQC	LRP2	3791	P98164
HEHLAMTFDCCYCPP	PTER	26	Q96BW5
EEYLDEFDPCHCRPC	C7	446	P10643
CPEPRADHAYCCIEM	ADCY9	451	O60503
HVNHYKCPLCDMTCP	HINFP	251	Q9BQA5
DTCPRAYHMVCLDPD	CHD4	386	Q14839
SYHIMCRPCACELEV	C9orf85	81	Q96MD7
EFEGYRMCICHLPCR	TRMT1L	151	Q7Z2T5
LICPVCDRSHCMPYS	TRIM42	186	Q8IWZ5
EAFYCVRPQHMPCEA	NXPE2	251	Q96DL1
FCPMCLECDIARHYG	PLAC8L1	91	A1L4L8
VTEALRGHMCYCCPE	POGZ	386	Q7Z3K3
TIHDFECPMECFCPP	KERA	36	O60938
FDPCECVCSHEHAMR	SMIM14	6	Q96QK8
DHEELCEFRPYSCPC	SIAH1	116	Q8IUQ4
EHEDICEYRPYSCPC	SIAH2	156	O43255
HCETIPCKDDEYCME	TECTA	1071	O75443
DLMADVVYCPRPCCQ	RNF14	301	Q9UBS8
HRCEMPSPELCLVCE	USP27X	111	A6NNY8
CRADDCPFLMPICSH	ZPLD1	301	Q8TCW7
HTCEKPYECRECGMA	ZNF565	481	Q8N9K5
CCMESGPRFCADHPF	SERPINB9	341	P50453
DCMDPDCCLQPLCHI	TENM4	851	Q6N022
EDCDQPLYDCPMCGL	ZUP1	186	Q96AP4
FYHWDPRMPCQPCDC	LAMC3	371	Q9Y6N6