Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	MTMR6 MTMR7 MTMR8	1.41e-06	11	42	3	GO:0052629
GeneOntologyMolecularFunction	phosphatidylinositol-3-phosphate phosphatase activity	MTMR6 MTMR7 MTMR8	3.10e-06	14	42	3	GO:0004438
GeneOntologyMolecularFunction	phosphatidylinositol monophosphate phosphatase activity	MTMR6 MTMR7 MTMR8	3.87e-06	15	42	3	GO:0052744
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate phosphatase activity	MTMR6 MTMR7 MTMR8	4.75e-06	16	42	3	GO:0106018
GeneOntologyMolecularFunction	phosphatidylinositol bisphosphate phosphatase activity	MTMR6 MTMR7 MTMR8	2.44e-05	27	42	3	GO:0034593
GeneOntologyMolecularFunction	phosphatidylinositol phosphate phosphatase activity	MTMR6 MTMR7 MTMR8	3.38e-05	30	42	3	GO:0052866
GeneOntologyBiologicalProcess	phosphatidylinositol dephosphorylation	MTMR6 MTMR7 MTMR8	2.65e-05	30	40	3	GO:0046856
Domain	KRAB	ZNF611 ZNF599 ZNF765 ZNF224 ZNF468 ZNF443 ZNF551 ZNF404	1.13e-06	358	42	8	PS50805
Domain	KRAB	ZNF611 ZNF599 ZNF765 ZNF224 ZNF468 ZNF443 ZNF551 ZNF404	1.13e-06	358	42	8	PF01352
Domain	KRAB	ZNF611 ZNF599 ZNF765 ZNF224 ZNF468 ZNF443 ZNF551 ZNF404	1.41e-06	369	42	8	SM00349
Domain	KRAB	ZNF611 ZNF599 ZNF765 ZNF224 ZNF468 ZNF443 ZNF551 ZNF404	1.44e-06	370	42	8	IPR001909
Domain	PPASE_MYOTUBULARIN	MTMR6 MTMR7 MTMR8	3.78e-06	14	42	3	PS51339
Domain	Myotubularin_fam	MTMR6 MTMR7 MTMR8	3.78e-06	14	42	3	IPR030564
Domain	Myotub-related	MTMR6 MTMR7 MTMR8	3.78e-06	14	42	3	PF06602
Domain	Myotubularin-like_Pase_dom	MTMR6 MTMR7 MTMR8	3.78e-06	14	42	3	IPR010569
Domain	zf-C2H2_6	ZNF611 ZNF765 ZNF224 ZNF468 ZNF443 ZNF551 ZNF404	5.78e-06	314	42	7	PF13912
Domain	-	ZNF611 ZNF599 ZNF765 ZNF224 ZNF468 ZNF443 ZFPM2 ZNF551 ZNF404	1.60e-05	679	42	9	3.30.160.60
Domain	zf-C2H2	ZNF611 ZNF599 ZNF765 ZNF224 ZNF468 ZNF443 ZFPM2 ZNF551 ZNF404	1.88e-05	693	42	9	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF611 ZNF599 ZNF765 ZNF224 ZNF468 ZNF443 ZFPM2 ZNF551 ZNF404	1.90e-05	694	42	9	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF611 ZNF599 ZNF765 ZNF224 ZNF468 ZNF443 ZFPM2 ZNF551 ZNF404	4.53e-05	775	42	9	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF611 ZNF599 ZNF765 ZNF224 ZNF468 ZNF443 ZFPM2 ZNF551 ZNF404	4.62e-05	777	42	9	PS00028
Domain	Znf_C2H2-like	ZNF611 ZNF599 ZNF765 ZNF224 ZNF468 ZNF443 ZFPM2 ZNF551 ZNF404	5.57e-05	796	42	9	IPR015880
Domain	Znf_C2H2	ZNF611 ZNF599 ZNF765 ZNF224 ZNF468 ZNF443 ZFPM2 ZNF551 ZNF404	6.08e-05	805	42	9	IPR007087
Domain	ZnF_C2H2	ZNF611 ZNF599 ZNF765 ZNF224 ZNF468 ZNF443 ZFPM2 ZNF551 ZNF404	6.25e-05	808	42	9	SM00355
Domain	PTPc_motif	MTMR6 MTMR7 MTMR8	3.15e-04	59	42	3	SM00404
Domain	Tyr_Pase_cat	MTMR6 MTMR7 MTMR8	3.15e-04	59	42	3	IPR003595
Domain	HEAT_REPEAT	MTOR AP3D1 TANGO6	5.21e-04	70	42	3	PS50077
Domain	Tyr_Pase_AS	MTMR6 MTMR7 MTMR8	5.89e-04	73	42	3	IPR016130
Domain	TYR_PHOSPHATASE_1	MTMR6 MTMR7 MTMR8	9.50e-04	86	42	3	PS00383
Domain	Prot-tyrosine_phosphatase-like	MTMR6 MTMR7 MTMR8	1.43e-03	99	42	3	IPR029021
Domain	Olfact_rcpt	OR10K1 OR5D16 OR10H4 OR6C68	1.15e-02	393	42	4	IPR000725
Domain	-	MTOR AP3D1 TANGO6	1.35e-02	222	42	3	1.25.10.10
Pathway	WP_PHOSPHOINOSITIDES_METABOLISM	MTMR6 MTMR7 MTMR8	1.66e-04	49	31	3	M40046
Pathway	WP_8P231_COPY_NUMBER_VARIATION_SYNDROME	MTMR6 MTMR7 MTMR8	2.21e-04	54	31	3	M48073
Pubmed	Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions.	MTMR6 MTMR7 MTMR8	4.12e-07	12	44	3	16787938
Pubmed	Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9.	MTMR6 MTMR7	4.69e-06	3	44	2	12890864
Pubmed	Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8.	MTMR6 MTMR8	4.69e-06	3	44	2	22647598
Pubmed	The myotubularin family: from genetic disease to phosphoinositide metabolism.	MTMR7 MTMR8	4.69e-06	3	44	2	11275328
Pubmed	T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10.	MALT1 MTOR	9.37e-06	4	44	2	24917592
Pubmed	Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.	MTMR6 MTMR7	6.99e-05	10	44	2	9736772
Pubmed	Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes.	SLC30A1 AP3D1	6.99e-05	10	44	2	17349999
Pubmed	Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients.	MTOR BRWD3	1.41e-04	14	44	2	28878358
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	MCM2 AMFR MTMR6 MTMR7 FAM120A MTOR MTMR8	2.05e-04	974	44	7	28675297
Pubmed	Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.	ZNF224 ZNF404	2.93e-04	20	44	2	12743021
Pubmed	Multiple genes encoding zinc finger domains are expressed in human T cells.	ZNF224 ZNF551	7.11e-04	31	44	2	2288909
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR10K1 OR5D16 OR10H4 OR6C68	8.95e-04	340	44	4	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR10K1 OR5D16 OR10H4 OR6C68	8.95e-04	340	44	4	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR10K1 OR5D16 OR10H4 OR6C68	9.25e-04	343	44	4	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR10K1 OR5D16 OR10H4 OR6C68	9.55e-04	346	44	4	14611657
Pubmed	Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development.	HJV MTMR7	1.13e-03	39	44	2	38226173
Pubmed	F-box only protein 9 is an E3 ubiquitin ligase of PPARγ.	AP3D1 ZNF404	1.18e-03	40	44	2	27197753
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	MTMR6 MTMR7 MTMR8	1.25e-03	167	44	3	25659891
Interaction	MTMR8 interactions	MTMR6 MTMR7 MTMR8	1.62e-05	25	40	3	int:MTMR8
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF611 CAPN12 ZNF599 ZNF765 ZNF224 ZNF468 ZNF551 ZNF404	1.56e-05	1192	44	8	chr19q13
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	PLIN4 OR10H4 CACTIN AP3D1 ZNF443	9.66e-04	797	44	5	chr19p13
Cytoband	19p13.3	PLIN4 CACTIN AP3D1	1.54e-03	237	44	3	19p13.3
Cytoband	19q13.41	ZNF611 ZNF468	2.57e-03	78	44	2	19q13.41
Cytoband	20p13	PCED1A DNAAF9	4.35e-03	102	44	2	20p13
Cytoband	16q22.1	CARMIL2 TANGO6	5.04e-03	110	44	2	16q22.1
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	MTMR6 MTMR7 MTMR8	2.26e-06	15	32	3	903
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF611 ZNF599 ZNF765 ZNF224 ZNF468 ZNF443 ZFPM2 ZNF551 ZNF404	2.88e-06	718	32	9	28
GeneFamily	Phosphoinositide phosphatases	MTMR6 MTMR7 MTMR8	2.41e-05	32	32	3	1079
GeneFamily	Olfactory receptors, family 10	OR10K1 OR10H4	6.07e-03	66	32	2	157
Disease	centronuclear myopathy (implicated_via_orthology)	MTMR6 MTMR7 MTMR8	9.35e-08	7	42	3	DOID:14717 (implicated_via_orthology)
Disease	centronuclear myopathy X-linked (implicated_via_orthology)	MTMR6 MTMR7 MTMR8	2.24e-07	9	42	3	DOID:0111225 (implicated_via_orthology)
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	MTMR6 MTMR7 MTMR8	5.32e-06	24	42	3	DOID:10595 (implicated_via_orthology)
Disease	peripheral neuropathy, response to antimicrotubule agent	SCUBE1 ZFPM2	4.91e-04	23	42	2	EFO_0003100, EFO_0005260
Disease	Malignant neoplasm of breast	AMFR PDE2A MTOR VPS13B ANKEF1 ZNF404 MTMR8	7.34e-04	1074	42	7	C0006142
Disease	Papillary Renal Cell Carcinoma	DNHD1 ZNF765 MTOR	8.09e-04	128	42	3	C1306837
Disease	Renal Cell Carcinoma	DNHD1 ZNF765 MTOR	8.09e-04	128	42	3	C0007134
Disease	Sarcomatoid Renal Cell Carcinoma	DNHD1 ZNF765 MTOR	8.09e-04	128	42	3	C1266043
Disease	Chromophobe Renal Cell Carcinoma	DNHD1 ZNF765 MTOR	8.09e-04	128	42	3	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	DNHD1 ZNF765 MTOR	8.09e-04	128	42	3	C1266044
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	DNHD1 ZNF765 MTOR	1.23e-03	148	42	3	C0279702
Disease	Combined immunodeficiency	MALT1 CARMIL2	1.57e-03	41	42	2	C0494261

Protein segments in the cluster

Peptide	Gene	Start	Entry
NVRHSEHEFLFHYCG	ARSF	436	P54793
HRQGCRHFSLGDFSH	CARMIL2	186	Q6F5E8
NHFACTDSHGHLLLF	BRWD3	526	Q6RI45
VNAFDNDRHHAAHFA	ANKEF1	211	Q9NU02
RFHQQVCSHLHLFFL	DNHD1	3001	Q96M86
FQNLLAKICFHHHFS	AP3D1	1081	O14617
RSFHHHFHTCRVQGA	HJV	176	Q6ZVN8
HGFNTINHFFCELSS	OR5D16	171	Q8NGK9
NFLRTHVDSHGHNVF	MCM2	201	P49736
FISSFAHHASCHFSR	MALT1	786	Q9UDY8
HEHIHSCQFGNFLGN	MTMR6	426	Q9Y217
HIQHHIYSCQFGNFL	MTMR7	426	Q9Y216
EIHDHVFSCQFGNFL	MTMR8	426	Q96EF0
HQHLFSHLTQAAFRC	ZFPM2	351	Q8WW38
QDFHFTLREHSNCSH	B3GALNT1	61	O75752
AILNTHGCNIFDHFS	PDE2A	736	O00408
AGDHCFDVLDLHFHF	PCED1A	221	Q9H1Q7
HHQEVIGFCRENGFH	FAM120A	166	Q9NZB2
SHQLFHICAVLGTHF	PAQR6	256	Q6TCH4
HLTFCGSNVIHHFFC	OR10H4	166	Q8NGA5
GSNVIHHFFCHVLSL	OR10H4	171	Q8NGA5
FNDFTGHLNFQIEHH	FADS2B	411	A8MWK0
LQCFGHGQSLALHHF	CAPN12	601	Q6ZSI9
NVHFFSSGLLFSHCR	DNAAF9	561	Q5TEA3
SHRHGFRCQFANGIF	CACTIN	731	Q8WUQ7
THNTANEVFHCVHFE	BTBD9	541	Q96Q07
GFFLSDNQHTCIHRS	SCUBE1	146	Q8IWY4
LPFHSSNQLHHFFCD	OR10K1	166	Q8NGX5
GHSLTQFVRHCADHF	MTOR	596	P42345
QFVRHCADHFLNSEH	MTOR	601	P42345
RAFEHAVSHLQHGQF	PLIN4	1191	Q96Q06
GFHLEFCDSNVINHF	OR6C68	161	A6NDL8
NQHNHFFHFDGSRIA	AMFR	416	Q9UKV5
CGKAFTHHSVFIRHN	ZNF599	456	Q96NL3
CNFISNFYSHSRLHH	REV1	346	Q9UBZ9
FCFSADLHQHQKHYN	ZNF551	141	Q7Z340
AQHTSLGSLIFCHHF	TANGO6	206	Q9C0B7
AFSHCYQLSQHQRFH	ZNF404	531	Q494X3
VSFQFAHLEFHLCHH	VPS13B	2481	Q7Z7G8
QCGKAFHHLGSFQRH	ZNF443	341	Q9Y2A4
RHESHHNGDFCFQDI	ZNF765	76	Q7L2R6
QRHESHHIGDFCFQE	ZNF611	91	Q8N823
SFSDVSHFDFHQQLH	ZNF224	156	Q9NZL3
LCLFHHHSGFSQDSG	SLC30A1	131	Q9Y6M5
RQASHHIGEFCFHEI	ZNF468	76	Q5VIY5
FTFGHCHRNLNHFET	WFIKKN2	356	Q8TEU8