Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Znf-RING_LisH	RC3H2 SH3RF2	2.06e-03	34	37	2	IPR027370
Domain	zf-RING_UBOX	RC3H2 SH3RF2	2.06e-03	34	37	2	PF13445
Domain	WW	SMURF1 UTRN	3.90e-03	47	37	2	PF00397
Domain	WW	SMURF1 UTRN	4.07e-03	48	37	2	SM00456
Domain	ARM-type_fold	MROH7 PKP1 HEATR5A PI4KA	4.39e-03	339	37	4	IPR016024
Domain	WW_DOMAIN_2	SMURF1 UTRN	4.58e-03	51	37	2	PS50020
Domain	WW_DOMAIN_1	SMURF1 UTRN	4.58e-03	51	37	2	PS01159
Domain	WW_dom	SMURF1 UTRN	4.76e-03	52	37	2	IPR001202
Domain	DH_1	ALS2 ARHGEF40	6.91e-03	63	37	2	PS00741
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	FRY MAGEB6 CFAP57 CYP26B1 BIRC6 UTRN PI4KA PRDM2	1.08e-06	736	38	8	29676528
Pubmed	IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ motif protein.	SCHIP1 IQCJ-SCHIP1	3.48e-06	3	38	2	17045569
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	YEATS2 EIF4ENIF1 ANKHD1 BIRC6 UTRN PRDM2	5.80e-06	418	38	6	34709266
Pubmed	Schwannomin-interacting Protein 1 Isoform IQCJ-SCHIP1 Is a Multipartner Ankyrin- and Spectrin-binding Protein Involved in the Organization of Nodes of Ranvier.	SCHIP1 IQCJ-SCHIP1	6.96e-06	4	38	2	27979964
Pubmed	CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.	SCHIP1 IQCJ-SCHIP1	1.16e-05	5	38	2	25950943
Pubmed	Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late component of nodes of Ranvier and axon initial segments.	SCHIP1 IQCJ-SCHIP1	1.16e-05	5	38	2	18550753
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DECR1 PKP1 ARHGEF40 ANKHD1 EP400 BIRC6 UTRN YTHDF2 PI4KA	1.17e-05	1353	38	9	29467282
Pubmed	Activity-dependent and graded BACE1 expression in the olfactory epithelium is mediated by the retinoic acid metabolizing enzyme CYP26B1.	CYP26B1 KIRREL2	3.24e-05	8	38	2	24797530
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SMURF1 YEATS2 ALS2 HEATR5A EP400	7.82e-05	407	38	5	12693553
Pubmed	Cell-free cotranslation and selection using in vitro virus for high-throughput analysis of protein-protein interactions and complexes.	SCHIP1 CFAP57	1.38e-04	16	38	2	15867431
Pubmed	Modifier genes and protective alleles in humans and mice.	ALS2 CFTR	1.38e-04	16	38	2	12787792
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	SMURF1 ALS2 ANKHD1 UTRN LMBRD1 PI4KA PRDM2	1.52e-04	1084	38	7	11544199
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ARHGEF40 EIF4ENIF1 ANKHD1 EP400 BIRC6 REXO1 PI4KA	1.71e-04	1105	38	7	35748872
Pubmed	Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.	EIF4ENIF1 ANKHD1 YTHDF2	2.21e-04	107	38	3	30995489
Pubmed	The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.	YEATS2 ARHGEF40 UTRN	3.49e-04	125	38	3	29467281
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	PKP1 YEATS2 ANKHD1 EP400 PI4KA	3.55e-04	564	38	5	21565611
Pubmed	Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.	SCHIP1 IQCJ-SCHIP1	6.38e-04	34	38	2	19197348
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	ALS2 BIRC6 UTRN MTMR10	6.51e-04	363	38	4	14691545
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	YEATS2 RC3H2 EP400 PRDM2	9.17e-04	398	38	4	35016035
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	EP400 UTRN YTHDF2 PI4KA	1.02e-03	410	38	4	26949251
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	RC3H2 EIF4ENIF1 ANKHD1 YTHDF2 SRRM4	1.09e-03	723	38	5	34133714
Interaction	FBXO3 interactions	SMURF1 DECR1 RC3H2 BIRC6	1.01e-05	72	38	4	int:FBXO3
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ALS2 ARHGEF40	3.44e-03	66	24	2	722
Drug	benzamyl	DECR1 CFTR	9.69e-05	9	38	2	CID000160884
Drug	fenarimol	AP3M2 CMYA5 PI4KA	1.31e-04	59	38	3	CID000043226
Drug	DCPIB	DECR1 CFTR	1.48e-04	11	38	2	CID010071166
Drug	N,N-dimethylaniline-N-oxide	DECR1 CFTR	1.48e-04	11	38	2	CID000000950
Drug	AC1NAD9E	DECR1 BIRC6	2.44e-04	14	38	2	CID004475105
Drug	Prednisone [53-03-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A	CDADC1 CYP26B1 PRDM2 CFTR	2.72e-04	189	38	4	4400_DN
Drug	Cloxacillin sodium salt [642-78-4]; Up 200; 8.8uM; PC3; HT_HG-U133A	CDADC1 RC3H2 UTRN PRDM2	3.07e-04	195	38	4	2126_UP
Drug	Tocainide hydrochloride; Down 200; 17.4uM; HL60; HT_HG-U133A	SMURF1 ARHGEF40 BPI PRDM2	3.19e-04	197	38	4	2931_DN
Drug	Nitrofurantoin [67-20-9]; Down 200; 16.8uM; HL60; HT_HG-U133A	SMURF1 EIF4ENIF1 BPI UTRN	3.19e-04	197	38	4	2341_DN
Drug	Pgh1	DECR1 CFTR	3.63e-04	17	38	2	CID005283048
Drug	8-azido-ADP	PI4KA CFTR	3.63e-04	17	38	2	CID000121934
Drug	CPD-4	DECR1 PKP1 PRDM2	4.56e-04	90	38	3	CID000000459
Drug	H3-32	DECR1 BPI	8.60e-04	26	38	2	CID000082553
Drug	T-I-Q	DECR1 BPI	9.98e-04	28	38	2	CID000039062
Drug	IANBD	DECR1 PI4KA	1.07e-03	29	38	2	CID000122214
Drug	PtdIns(4,5)P2	PI4KA CFTR	1.15e-03	30	38	2	CID000125105
Disease	isoleucine measurement	CFAP57 EIF4ENIF1	2.14e-03	56	36	2	EFO_0009793
Disease	corpus callosum volume measurement	SCHIP1 IQCJ-SCHIP1	6.65e-03	100	36	2	EFO_0010299

Protein segments in the cluster

Peptide	Gene	Start	Entry
LSSLPLTSVGNTGMK	EP400	331	Q96L91
NGLAALSPLSKGSME	ARHGEF40	1181	Q8TER5
MSTLNTLKAGGILNR	CFTR	961	P13569
NSNKSRMNPLGSGLA	BIRC6	1746	Q9NR09
GLLRSGKLTSSSPSM	ALS2	1136	Q96Q42
TQTGSMTGQIPRLSK	CDADC1	21	Q9BWV3
PLLNMGSRNTSKLNL	MROH7	216	Q68CQ1
KGVASLNQSALSRPM	RC3H2	116	Q9HBD1
KSRLLQASGGSLTGM	PCDHGA2	721	Q9Y5H1
LPSLKGTMSLQAGAS	AP3M2	351	P53677
LSLMGPQSGKSAVSR	KIAA0100	546	Q14667
LSGDNALPKSGLLMS	MAGEB6	276	Q8N7X4
PQTLLQMSGSVGSKA	GPR179	1671	Q6PRD1
SSTLRGMPSALKNGI	MTMR10	581	Q9NXD2
MSALPLNLIKGTRSA	LMBRD1	216	Q9NUN5
KSQGMLALSISPNRR	CFAP57	56	Q96MR6
TRMLLGPNTVSNSIG	CYP26B1	121	Q9NR63
SSLLQRSMSLNIGGA	PI4KA	1321	P42356
LGKGMTTLLSSLGAQ	DECR1	71	Q16698
SLQALKGILSSPMAR	HEATR5A	1776	Q86XA9
GMSISADLKLGSNPT	BPI	141	P17213
RSLNLKGASSPMNLS	CMYA5	921	Q8N3K9
MSSNLLPTLNSGGKV	CCDC38	1	Q502W7
QKNLMRIPGSSDGSS	KIRREL2	546	Q6UWL6
ASRKSTGQLNMNPGT	FRY	1951	Q5TBA9
SMQTPLGKTRARSSG	PRDM2	1526	Q13029
ALQNLTASKGLMSSG	PKP1	571	Q13835
GGQQLKTRTLSGMAS	REXO1	766	Q8N1G1
MGQLASGIRSSLLPT	UTRN	1856	P46939
GKPSLSSRLQSGMNL	SCHIP1	286	P0DPB3
SGKPSLSSRLQSGMN	IQCJ-SCHIP1	361	B3KU38
MSNPGTRRNGSSIKI	SMURF1	1	Q9HCE7
QRPASSNLLSGLMGS	EIF4ENIF1	536	Q9NRA8
INSRTGSKLGISPLM	ANKHD1	1181	Q8IWZ3
NLKGLMRPANSLLST	ERVFRD-1	81	P60508
NKGAMLENLSPTSRG	SRRM4	341	A7MD48
PGTMTLQDGRKSRTN	SH3RF2	91	Q8TEC5
MDPQSRSLKNAGSRS	TEX33	86	O43247
MSASSLLEQRPKGQG	YTHDF2	1	Q9Y5A9
SQLSKPGTTMLRVAG	YEATS2	936	Q9ULM3