Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	NR2E3 ZBTB38 ZNF460 ZNF521 ZNF101 ZNF302 ZNF623 ZNF14 ZNF17 WIZ ZNF540 ZBTB21 ZNF770 PLAGL2 ZNF561 RORC LHX5 ZFP92 PRDM15 ZNF292	5.41e-05	1412	107	20	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NR2E3 ZBTB38 ZNF460 ZNF521 ZNF101 ZNF302 ZNF623 CRY1 ZNF14 ZNF17 WIZ ZNF540 ZNF770 ZNF561 RORC ZFP92 PRDM15	3.22e-04	1244	107	17	GO:0000978
GeneOntologyMolecularFunction	MAP kinase kinase kinase activity	RAF1 ARAF BRAF	3.98e-04	27	107	3	GO:0004709
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	NR2E3 ZBTB38 ZNF460 ZNF521 ZNF101 ZNF302 ZNF623 CRY1 ZNF14 ZNF17 WIZ ZNF540 ZNF770 ZNF561 RORC ZFP92 PRDM15	4.13e-04	1271	107	17	GO:0000987
GeneOntologyBiologicalProcess	regulation of brain-derived neurotrophic factor-activated receptor activity	FAM72D FAM72C FAM72A FAM72B	6.59e-10	4	106	4	GO:0031551
GeneOntologyBiologicalProcess	negative regulation of brain-derived neurotrophic factor receptor signaling pathway	FAM72D FAM72C FAM72A FAM72B	3.28e-09	5	106	4	GO:0031549
GeneOntologyBiologicalProcess	regulation of brain-derived neurotrophic factor receptor signaling pathway	FAM72D FAM72C FAM72A FAM72B	2.28e-08	7	106	4	GO:0031548
GeneOntologyBiologicalProcess	brain-derived neurotrophic factor receptor signaling pathway	FAM72D FAM72C FAM72A FAM72B	6.34e-07	14	106	4	GO:0031547
GeneOntologyBiologicalProcess	negative regulation of protein tyrosine kinase activity	FAM72D FAM72C FAM72A FAM72B	1.63e-05	30	106	4	GO:0061099
GeneOntologyBiologicalProcess	negative regulation of signaling receptor activity	FAM72D FAM72C FAM72A FAM72B	2.40e-05	33	106	4	GO:2000272
GeneOntologyBiologicalProcess	regulation of protein tyrosine kinase activity	FAM72D FAM72C FAM72A GREM1 FAM72B	2.82e-05	69	106	5	GO:0061097
MousePheno	abnormal somatic hypermutation frequency	FAM72D FAM72C FAM72A FAM72B	3.79e-06	19	81	4	MP:0004815
MousePheno	polycystic kidney	FAM72D FAM72C TTBK2 FAM72A AGTR2 FAM72B	1.50e-05	92	81	6	MP:0008528
MousePheno	increased B cell apoptosis	FAM72D FAM72C FAM72A FAM72B	1.93e-05	28	81	4	MP:0008782
MousePheno	increased germinal center B cell number	FAM72D FAM72C FAM72A FAM72B	2.92e-05	31	81	4	MP:0008177
Domain	FAM72	FAM72D FAM72C FAM72A FAM72B	9.80e-10	4	106	4	PF14976
Domain	FAM72	FAM72D FAM72C FAM72A FAM72B	9.80e-10	4	106	4	IPR026768
Domain	ZINC_FINGER_C2H2_1	ZBTB38 ZNF460 ZNF521 ZNF101 ZNF302 ZNF623 ZNF14 ZNF17 ZNF800 ZNF469 WIZ ZNF540 ZBTB21 CIZ1 ZNF770 PLAGL2 ZNF561 ZFP92 PRDM15 ZNF653 ZNF292	2.16e-09	777	106	21	PS00028
Domain	Znf_C2H2-like	ZBTB38 ZNF460 ZNF521 ZNF101 ZNF302 ZNF623 ZNF14 ZNF17 ZNF800 ZNF469 WIZ ZNF540 ZBTB21 CIZ1 ZNF770 PLAGL2 ZNF561 ZFP92 PRDM15 ZNF653 ZNF292	3.32e-09	796	106	21	IPR015880
Domain	Znf_C2H2	ZBTB38 ZNF460 ZNF521 ZNF101 ZNF302 ZNF623 ZNF14 ZNF17 ZNF800 ZNF469 WIZ ZNF540 ZBTB21 CIZ1 ZNF770 PLAGL2 ZNF561 ZFP92 PRDM15 ZNF653 ZNF292	4.05e-09	805	106	21	IPR007087
Domain	ZnF_C2H2	ZBTB38 ZNF460 ZNF521 ZNF101 ZNF302 ZNF623 ZNF14 ZNF17 ZNF800 ZNF469 WIZ ZNF540 ZBTB21 CIZ1 ZNF770 PLAGL2 ZNF561 ZFP92 PRDM15 ZNF653 ZNF292	4.33e-09	808	106	21	SM00355
Domain	Znf_C2H2/integrase_DNA-bd	ZBTB38 ZNF460 ZNF521 ZNF101 ZNF302 ZNF623 ZNF14 ZNF17 ZNF800 ZNF469 ZNF540 ZBTB21 ZNF770 PLAGL2 ZNF561 ZFP92 PRDM15 ZNF653 ZNF292	1.14e-08	694	106	19	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZBTB38 ZNF460 ZNF521 ZNF101 ZNF302 ZNF623 ZNF14 ZNF17 ZNF800 ZNF469 WIZ ZNF540 ZBTB21 ZNF770 PLAGL2 ZNF561 ZFP92 PRDM15 ZNF653 ZNF292	1.21e-08	775	106	20	PS50157
Domain	-	ZBTB38 ZNF460 ZNF521 ZNF101 ZNF302 ZNF623 ZNF14 ZNF17 ZNF800 ZNF540 ZBTB21 ZNF770 PLAGL2 ZNF561 ZFP92 PRDM15 ZNF653 ZNF292	4.77e-08	679	106	18	3.30.160.60
Domain	zf-C2H2	ZBTB38 ZNF460 ZNF521 ZNF101 ZNF302 ZNF623 ZNF14 ZNF17 ZNF469 ZNF540 ZBTB21 ZNF770 PLAGL2 ZNF561 ZFP92 PRDM15 ZNF653 ZNF292	6.48e-08	693	106	18	PF00096
Domain	Furin-like_2	RSPO4 RSPO3 RSPO2	7.08e-07	4	106	3	PF15913
Domain	RBD	RAF1 ARAF BRAF	3.51e-06	6	106	3	PF02196
Domain	DAG/PE-bd	RAF1 ARAF BRAF PRKCE	5.45e-06	21	106	4	IPR020454
Domain	RBD	RAF1 ARAF BRAF	6.12e-06	7	106	3	SM00455
Domain	RBD_dom	RAF1 ARAF BRAF	6.12e-06	7	106	3	IPR003116
Domain	RBD	RAF1 ARAF BRAF	6.12e-06	7	106	3	PS50898
Domain	zf-C2H2_6	ZNF521 ZNF302 ZNF14 ZNF17 ZNF540 ZNF770 PLAGL2 ZNF561 ZFP92	7.53e-05	314	106	9	PF13912
Domain	Furin_repeat	RSPO4 RSPO3 RSPO2	1.36e-04	18	106	3	IPR006212
Domain	FU	RSPO4 RSPO3 RSPO2	1.36e-04	18	106	3	SM00261
Domain	MANEC	MANSC1 LRP11	1.90e-04	4	106	2	PF07502
Domain	C1_1	RAF1 ARAF BRAF PRKCE	3.07e-04	57	106	4	PF00130
Domain	MANSC_N	MANSC1 LRP11	3.16e-04	5	106	2	IPR011106
Domain	MANEC	MANSC1 LRP11	3.16e-04	5	106	2	SM00765
Domain	MANSC_dom	MANSC1 LRP11	4.72e-04	6	106	2	IPR013980
Domain	MANSC	MANSC1 LRP11	4.72e-04	6	106	2	PS50986
Domain	ZF_DAG_PE_1	RAF1 ARAF BRAF PRKCE	4.79e-04	64	106	4	PS00479
Domain	ZF_DAG_PE_2	RAF1 ARAF BRAF PRKCE	4.79e-04	64	106	4	PS50081
Domain	C1	RAF1 ARAF BRAF PRKCE	5.09e-04	65	106	4	SM00109
Domain	TSP1	RSPO4 ADAMTS10 RSPO3 RSPO2	5.09e-04	65	106	4	SM00209
Domain	TSP1_rpt	RSPO4 ADAMTS10 RSPO3 RSPO2	5.09e-04	65	106	4	IPR000884
Domain	TSP1	RSPO4 ADAMTS10 RSPO3 RSPO2	5.09e-04	65	106	4	PS50092
Domain	PE/DAG-bd	RAF1 ARAF BRAF PRKCE	5.39e-04	66	106	4	IPR002219
Domain	KRAB	ZNF460 ZNF101 ZNF302 ZNF14 ZNF17 ZNF540 ZNF561 ZFP92	9.95e-04	358	106	8	PS50805
Domain	KRAB	ZNF460 ZNF101 ZNF302 ZNF14 ZNF17 ZNF540 ZNF561 ZFP92	9.95e-04	358	106	8	PF01352
Domain	KRAB	ZNF460 ZNF101 ZNF302 ZNF14 ZNF17 ZNF540 ZNF561 ZFP92	1.21e-03	369	106	8	SM00349
Domain	KRAB	ZNF460 ZNF101 ZNF302 ZNF14 ZNF17 ZNF540 ZNF561 ZFP92	1.23e-03	370	106	8	IPR001909
Domain	GPCR_Rhodpsn_7TM	GPR20 CCRL2 CHRM4 OR12D3 OXTR GPR75 AGTR2 HRH2 OR4K5 TACR3 GPR132	1.48e-03	670	106	11	IPR017452
Domain	7tm_1	GPR20 CCRL2 CHRM4 OR12D3 OXTR GPR75 AGTR2 HRH2 OR4K5 TACR3 GPR132	1.60e-03	677	106	11	PF00001
Domain	G_PROTEIN_RECEP_F1_1	GPR20 CCRL2 CHRM4 OR12D3 OXTR GPR75 AGTR2 HRH2 OR4K5 TACR3 GPR132	1.76e-03	685	106	11	PS00237
Domain	G_PROTEIN_RECEP_F1_2	GPR20 CCRL2 CHRM4 OR12D3 OXTR GPR75 AGTR2 HRH2 OR4K5 TACR3 GPR132	1.88e-03	691	106	11	PS50262
Domain	GPCR_Rhodpsn	GPR20 CCRL2 CHRM4 OR12D3 OXTR GPR75 AGTR2 HRH2 OR4K5 TACR3 GPR132	1.90e-03	692	106	11	IPR000276
Domain	Tetraspanin_CS	TSPAN12 TSPAN5	6.25e-03	21	106	2	IPR018503
Pathway	REACTOME_SIGNALING_BY_MRAS_COMPLEX_MUTANTS	RAF1 ARAF BRAF	6.73e-06	8	71	3	M38999
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_MRAS_SHOC2_PP1_HOLOPHOSPHATASE	RAF1 ARAF BRAF	6.73e-06	8	71	3	M47933
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	1.43e-05	10	71	3	M47374
Pathway	KEGG_MEDICUS_VARIANT_HRAS_OVEREXPRESSION_TO_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	1.43e-05	10	71	3	M47420
Pathway	KEGG_MEDICUS_REFERENCE_RAC_CDC42_PAK_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	1.43e-05	10	71	3	M47735
Pathway	KEGG_MEDICUS_VARIANT_RET_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	1.96e-05	11	71	3	M47370
Pathway	KEGG_MEDICUS_VARIANT_TRK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	1.96e-05	11	71	3	M47371
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	2.61e-05	12	71	3	M47369
Pathway	KEGG_MEDICUS_PATHOGEN_HBV_LHBS_TO_PKC_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	2.61e-05	12	71	3	M47597
Pathway	KEGG_MEDICUS_ENV_FACTOR_METALS_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	2.61e-05	12	71	3	M47815
Pathway	KEGG_MEDICUS_PATHOGEN_HCV_CORE_TO_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	3.38e-05	13	71	3	M47589
Pathway	KEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	4.28e-05	14	71	3	M47364
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	4.28e-05	14	71	3	M47365
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	4.28e-05	14	71	3	M47366
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	4.28e-05	14	71	3	M47378
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PLCG_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	4.28e-05	14	71	3	M47383
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PLCG_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	4.28e-05	14	71	3	M47384
Pathway	KEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	4.28e-05	14	71	3	M47488
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	GPR20 CCRL2 CHRM4 OR12D3 OXTR GPR75 AGTR2 HRH2	4.69e-05	260	71	8	M39397
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	5.33e-05	15	71	3	M47367
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	5.33e-05	15	71	3	M47375
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	5.33e-05	15	71	3	M47382
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	5.33e-05	15	71	3	M47380
Pathway	KEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	5.33e-05	15	71	3	M47592
Pathway	KEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	5.33e-05	15	71	3	M47593
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_FGF17_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	5.33e-05	15	71	3	M47640
Pathway	KEGG_MEDICUS_VARIANT_IGF2_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	5.33e-05	15	71	3	M47485
Pathway	KEGG_MEDICUS_REFERENCE_HGF_MET_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	5.33e-05	15	71	3	M47473
Pathway	KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	5.33e-05	15	71	3	M47474
Pathway	KEGG_MEDICUS_REFERENCE_TGFA_EGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	5.33e-05	15	71	3	M47480
Pathway	KEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	5.33e-05	15	71	3	M47495
Pathway	KEGG_MEDICUS_REFERENCE_EREG_EGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	5.33e-05	15	71	3	M47496
Pathway	KEGG_MEDICUS_REFERENCE_AREG_EGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	5.33e-05	15	71	3	M47497
Pathway	KEGG_MEDICUS_REFERENCE_KITLG_KIT_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	5.33e-05	15	71	3	M47472
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_GB_TO_PDGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	5.33e-05	15	71	3	M47535
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E5_TO_EGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	5.33e-05	15	71	3	M47531
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	6.54e-05	16	71	3	M47363
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_FGFR3_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	6.54e-05	16	71	3	M47373
Pathway	KEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	6.54e-05	16	71	3	M47381
Pathway	KEGG_MEDICUS_REFERENCE_P4_PR_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	6.54e-05	16	71	3	M47804
Pathway	KEGG_MEDICUS_ENV_FACTOR_E2_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	6.54e-05	16	71	3	M47801
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGF1R_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	6.54e-05	16	71	3	M47483
Pathway	KEGG_MEDICUS_REFERENCE_AGE_RAGE_SIGNALING_PATHWAY	RAF1 ARAF BRAF	6.54e-05	16	71	3	M47682
Pathway	KEGG_MEDICUS_REFERENCE_PDGF_PDGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	7.91e-05	17	71	3	M47376
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_AGE_RAGE_SIGNALING_PATHWAY	RAF1 ARAF BRAF	7.91e-05	17	71	3	M47684
Pathway	WP_INHIBITION_OF_EXOSOME_BIOGENESIS_AND_SECRETION_BY_MANUMYCIN_A_IN_CRPC_CELLS	RAF1 ARAF BRAF	9.46e-05	18	71	3	M39737
Pathway	KEGG_MEDICUS_REFERENCE_CXCL12_CXCR4_PKC_ERK_SIGNALING_PATHAWAY	RAF1 ARAF BRAF	1.12e-04	19	71	3	M47596
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	1.12e-04	19	71	3	M47793
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_LGR_RSPO	RSPO4 RSPO3 RSPO2	1.12e-04	19	71	3	M47833
Pathway	REACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION	RSPO4 RSPO3 RSPO2	1.31e-04	20	71	3	MM15155
Pathway	KEGG_MEDICUS_REFERENCE_ACH_CHRN_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	1.53e-04	21	71	3	M47792
Pathway	REACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION	RSPO4 RSPO3 RSPO2	1.53e-04	21	71	3	M27401
Pathway	KEGG_MEDICUS_REFERENCE_E2_ER_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	2.02e-04	23	71	3	M47799
Pathway	WP_NOVEL_JUNDMP1_PATHWAY	RAF1 ARAF BRAF	2.60e-04	25	71	3	MM15984
Pathway	KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION	RAF1 CACNA1D ARAF BRAF PRKCE	2.81e-04	115	71	5	M9387
Pathway	WP_MAPK_CASCADE	RAF1 ARAF BRAF	3.66e-04	28	71	3	MM15976
Pathway	WP_PILOCYTIC_ASTROCYTOMA	RAF1 BRAF	3.70e-04	6	71	2	M39584
Pathway	REACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY	RAF1 BRAF	3.70e-04	6	71	2	M27559
Pathway	REACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY	RAF1 BRAF	3.70e-04	6	71	2	MM15273
Pathway	WP_GPCRS_NONODORANT	CCRL2 CHRM4 OXTR AGTR2 HRH2 TACR3 GPR132	3.74e-04	266	71	7	MM15843
Pathway	WP_MAPK_CASCADE	RAF1 ARAF BRAF	5.99e-04	33	71	3	M39594
Pathway	REACTOME_RAF_ACTIVATION	RAF1 ARAF BRAF	6.55e-04	34	71	3	M27556
Pathway	REACTOME_RAF_ACTIVATION	RAF1 ARAF BRAF	7.14e-04	35	71	3	MM15271
Pathway	KEGG_MEDICUS_REFERENCE_FGF_FGFR_RAS_ERK_SIGNALING_PATHWAY	RAF1 ARAF BRAF	7.14e-04	35	71	3	M47379
Pathway	REACTOME_MAP2K_AND_MAPK_ACTIVATION	RAF1 ARAF BRAF	9.82e-04	39	71	3	MM15272
Pathway	WP_BLADDER_CANCER	RAF1 ARAF BRAF	1.06e-03	40	71	3	M39523
Pathway	REACTOME_MAP2K_AND_MAPK_ACTIVATION	RAF1 ARAF BRAF	1.06e-03	40	71	3	M27557
Pathway	REACTOME_NEGATIVE_REGULATION_OF_MAPK_PATHWAY	RAF1 ARAF BRAF	1.22e-03	42	71	3	MM15274
Pathway	KEGG_BLADDER_CANCER	RAF1 ARAF BRAF	1.22e-03	42	71	3	M19096
Pathway	REACTOME_NEGATIVE_REGULATION_OF_MAPK_PATHWAY	RAF1 ARAF BRAF	1.31e-03	43	71	3	M27560
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	CCRL2 CHRM4 OXTR AGTR2 HRH2 TACR3 GPR132	1.33e-03	330	71	7	M18334
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	CCRL2 CHRM4 OXTR AGTR2 HRH2 TACR3 GPR132	1.40e-03	333	71	7	MM14963
Pathway	REACTOME_SIGNALING_BY_MODERATE_KINASE_ACTIVITY_BRAF_MUTANTS	RAF1 ARAF BRAF	1.49e-03	45	71	3	M27623
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	CACNA1D RYR3 OXTR HRH2 TACR3	2.02e-03	178	71	5	M2890
Pathway	PID_TCR_RAS_PATHWAY	RAF1 BRAF	2.19e-03	14	71	2	M134
Pathway	KEGG_ENDOMETRIAL_CANCER	RAF1 ARAF BRAF	2.27e-03	52	71	3	M19877
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	CCRL2 CHRM4 OXTR AGTR2 HRH2	2.44e-03	186	71	5	MM15994
Pathway	KEGG_NON_SMALL_CELL_LUNG_CANCER	RAF1 ARAF BRAF	2.53e-03	54	71	3	M19818
Pathway	WP_MAPK_PATHWAY_IN_CONGENITAL_THYROID_CANCER	RAF1 BRAF	2.87e-03	16	71	2	M39882
Pathway	KEGG_ACUTE_MYELOID_LEUKEMIA	RAF1 ARAF BRAF	2.95e-03	57	71	3	M19888
Pathway	WP_MET_IN_TYPE_1_PAPILLARY_RENAL_CELL_CARCINOMA	RAF1 ARAF BRAF	3.25e-03	59	71	3	M39750
Pathway	KEGG_COLORECTAL_CANCER	RAF1 ARAF BRAF	3.74e-03	62	71	3	M14631
Pathway	WP_ENDOMETRIAL_CANCER	RAF1 ARAF BRAF	3.92e-03	63	71	3	M39623
Pathway	PID_CD8_TCR_DOWNSTREAM_PATHWAY	RAF1 BRAF PRKCE	4.28e-03	65	71	3	M272
Pathway	KEGG_GLIOMA	RAF1 ARAF BRAF	4.28e-03	65	71	3	M1835
Pathway	REACTOME_SIGNALING_BY_BRAF_AND_RAF1_FUSIONS	RAF1 ARAF BRAF	4.28e-03	65	71	3	M38994
Pathway	KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	RAF1 MYH9 CHRM4 ARAF BRAF	4.36e-03	213	71	5	M18306
Pubmed	Fam72a enforces error-prone DNA repair during antibody diversification.	FAM72D FAM72C FAM72A FAM72B	9.47e-11	4	110	4	34819671
Pubmed	Identification and characterisation of the novel amyloid-beta peptide-induced protein p17.	FAM72D FAM72C FAM72A FAM72B	4.72e-10	5	110	4	19755123
Pubmed	All-or-(N)One - an epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene loci.	FAM72D FAM72C FAM72A FAM72B	4.72e-10	5	110	4	26206078
Pubmed	FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation.	FAM72D FAM72C FAM72A FAM72B	1.41e-09	6	110	4	34819670
Pubmed	RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.	RAF1 ARAF BRAF	3.08e-08	3	110	3	20130576
Pubmed	Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas.	RAF1 ARAF BRAF	3.08e-08	3	110	3	14688025
Pubmed	Expression of raf family proto-oncogenes in normal mouse tissues.	RAF1 ARAF BRAF	3.08e-08	3	110	3	1690378
Pubmed	Endothelial apoptosis in Braf-deficient mice.	RAF1 ARAF BRAF	3.08e-08	3	110	3	9207797
Pubmed	Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling.	RAF1 ARAF BRAF	3.08e-08	3	110	3	23352452
Pubmed	Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis.	RAF1 ARAF BRAF	3.08e-08	3	110	3	10704835
Pubmed	R-Spondin proteins: a novel link to beta-catenin activation.	RSPO4 RSPO3 RSPO2	3.08e-08	3	110	3	16357527
Pubmed	ARAF acts as a scaffold to stabilize BRAF:CRAF heterodimers.	RAF1 ARAF BRAF	3.08e-08	3	110	3	22926515
Pubmed	Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase by G protein and tyrosine kinase oncoproteins.	RAF1 ARAF BRAF	1.23e-07	4	110	3	8394352
Pubmed	Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells.	RAF1 ARAF BRAF	1.23e-07	4	110	3	8621729
Pubmed	Aberrant expression of COT is related to recurrence of papillary thyroid cancer.	RAF1 ARAF BRAF	1.23e-07	4	110	3	25674762
Pubmed	B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.	RAF1 ARAF BRAF	1.23e-07	4	110	3	7731720
Pubmed	Functional characterization of a PROTAC directed against BRAF mutant V600E.	RAF1 ARAF BRAF	1.23e-07	4	110	3	32778845
Pubmed	Dynamic expression of R-spondin family genes in mouse development.	RSPO4 RSPO3 RSPO2	1.23e-07	4	110	3	17035101
Pubmed	A conditional allele of Rspo3 reveals redundant function of R-spondins during mouse limb development.	RSPO4 RSPO3 RSPO2	1.23e-07	4	110	3	22610508
Pubmed	cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein.	FAM72D FAM72C FAM72A FAM72B	1.26e-07	15	110	4	1741163
Pubmed	Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors.	RAF1 ARAF BRAF	3.06e-07	5	110	3	24746704
Pubmed	Germline gain-of-function mutations in RAF1 cause Noonan syndrome.	RAF1 ARAF BRAF	3.06e-07	5	110	3	17603482
Pubmed	In vivo functions of mitogen-activated protein kinases: conclusions from knock-in and knock-out mice.	RAF1 ARAF BRAF	3.06e-07	5	110	3	17219248
Pubmed	Reconstitution of R-spondin:LGR4:ZNRF3 adult stem cell growth factor signaling complexes with recombinant proteins produced in Escherichia coli.	RSPO4 RSPO3 RSPO2	6.11e-07	6	110	3	24050775
Pubmed	Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.	RAF1 ARAF BRAF	6.11e-07	6	110	3	8157000
Pubmed	Engineering high-potency R-spondin adult stem cell growth factors.	RSPO4 RSPO3 RSPO2	6.11e-07	6	110	3	25504990
Pubmed	Spatiotemporal expression patterns of R-spondins and their receptors, Lgrs, in the developing mouse telencephalon.	RSPO4 RSPO3 RSPO2	1.07e-06	7	110	3	37651925
Pubmed	Differential activities and mechanisms of the four R-spondins in potentiating Wnt/β-catenin signaling.	RSPO4 RSPO3 RSPO2	1.07e-06	7	110	3	29752411
Pubmed	R-spondins/Lgrs expression in tooth development.	RSPO4 RSPO3 RSPO2	1.70e-06	8	110	3	24616052
Pubmed	Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation.	RAF1 ARAF BRAF	2.55e-06	9	110	3	19667065
Pubmed	AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness.	RAF1 ARAF BRAF	2.55e-06	9	110	3	30595535
Pubmed	A-raf and B-raf are dispensable for normal endochondral bone development, and parathyroid hormone-related peptide suppresses extracellular signal-regulated kinase activation in hypertrophic chondrocytes.	RAF1 ARAF BRAF	2.55e-06	9	110	3	17967876
Pubmed	Essential role of B-Raf in ERK activation during extraembryonic development.	RAF1 ARAF BRAF	3.63e-06	10	110	3	16432225
Pubmed	Secreted factor R-Spondin 2 is involved in refinement of patterning of the mammalian cochlea.	RSPO4 RSPO3 RSPO2	3.63e-06	10	110	3	23192966
Pubmed	Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.	L1CAM RSPO4 RSPO3 RSPO2	5.16e-06	36	110	4	24151333
Pubmed	R-Spondin 3 Regulates Mammalian Dental and Craniofacial Development.	RSPO4 RSPO3 RSPO2	6.63e-06	12	110	3	34449628
Pubmed	The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation.	RSPO4 RSPO3 RSPO2	6.63e-06	12	110	3	30146491
Pubmed	RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6.	RSPO4 RSPO3 RSPO2	6.63e-06	12	110	3	29769720
Pubmed	The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3.	RSPO4 RSPO3 RSPO2	8.60e-06	13	110	3	27313319
Pubmed	Targets of Raf in tumorigenesis.	RAF1 BRAF	9.91e-06	2	110	2	20047953
Pubmed	Mammalian Ras interacts directly with the serine/threonine kinase Raf.	RAF1 ARAF	9.91e-06	2	110	2	8334704
Pubmed	Elimination of B-RAF in oncogenic C-RAF-expressing alveolar epithelial type II cells reduces MAPK signal intensity and lung tumor growth.	RAF1 BRAF	9.91e-06	2	110	2	25096573
Pubmed	Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants.	RAF1 BRAF	9.91e-06	2	110	2	22826437
Pubmed	R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine.	RSPO3 RSPO2	9.91e-06	2	110	2	28695896
Pubmed	In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling.	RAF1 BRAF	9.91e-06	2	110	2	17018604
Pubmed	RSPO fusion transcripts in colorectal cancer in Japanese population.	RSPO3 RSPO2	9.91e-06	2	110	2	24847761
Pubmed	A-Raf and C-Raf differentially regulate mechanobiological response of osteoblasts to guide mechanical stress-induced differentiation.	RAF1 ARAF	9.91e-06	2	110	2	27240957
Pubmed	Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.	RAF1 BRAF	9.91e-06	2	110	2	15035987
Pubmed	R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers.	RSPO3 RSPO2	9.91e-06	2	110	2	33320737
Pubmed	B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms.	RAF1 BRAF	9.91e-06	2	110	2	15710605
Pubmed	BRAF splice variants in rheumatoid arthritis synovial fibroblasts activate MAPK through CRAF.	RAF1 BRAF	9.91e-06	2	110	2	23517740
Pubmed	A novel requirement for Janus kinases as mediators of drug resistance induced by fibroblast growth factor-2 in human cancer cells.	BRAF PRKCE	9.91e-06	2	110	2	21625473
Pubmed	Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells.	RAF1 BRAF	9.91e-06	2	110	2	25473895
Pubmed	Raf kinases in cancer-roles and therapeutic opportunities.	RAF1 BRAF	9.91e-06	2	110	2	21577205
Pubmed	Essential, non-redundant roles of B-Raf and Raf-1 in Ras-driven skin tumorigenesis.	RAF1 BRAF	9.91e-06	2	110	2	22733131
Pubmed	CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations.	RAF1 BRAF	9.91e-06	2	110	2	18794803
Pubmed	Application of a high-throughput genotyping method for loci exclusion in non-consanguineous Australian pedigrees with autosomal recessive retinitis pigmentosa.	CRB1 USH2A	9.91e-06	2	110	2	22876132
Pubmed	B-Raf and C-Raf are required for melanocyte stem cell self-maintenance.	RAF1 BRAF	9.91e-06	2	110	2	23022482
Pubmed	Identification of frequent BRAF copy number gain and alterations of RAF genes in Chinese prostate cancer.	RAF1 BRAF	9.91e-06	2	110	2	22833462
Pubmed	Rafs constitute a nodal point in the regulation of embryonic endothelial progenitor cell growth and differentiation.	RAF1 BRAF	9.91e-06	2	110	2	18205709
Pubmed	Epidermal RAF prevents allergic skin disease.	RAF1 BRAF	9.91e-06	2	110	2	27431613
Pubmed	RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation.	RAF1 BRAF	9.91e-06	2	110	2	23680146
Pubmed	ERK MAP kinase signaling in post-mortem brain of suicide subjects: differential regulation of upstream Raf kinases Raf-1 and B-Raf.	RAF1 BRAF	9.91e-06	2	110	2	16172610
Pubmed	BRAF inactivation drives aneuploidy by deregulating CRAF.	RAF1 BRAF	9.91e-06	2	110	2	20978199
Pubmed	Active Ras induces heterodimerization of cRaf and BRaf.	RAF1 BRAF	9.91e-06	2	110	2	11325826
Pubmed	RAF inhibitors that evade paradoxical MAPK pathway activation.	RAF1 BRAF	9.91e-06	2	110	2	26466569
Pubmed	Griffipavixanthone, a dimeric xanthone extracted from edible plants, inhibits tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer.	RAF1 BRAF	9.91e-06	2	110	2	26646323
Pubmed	Mutations in R-spondin 4 (RSPO4) underlie inherited anonychia.	RSPO4 RSPO3	9.91e-06	2	110	2	17805348
Pubmed	R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling.	RSPO3 RSPO2	9.91e-06	2	110	2	32432544
Pubmed	A-Raf and Raf-1 work together to influence transient ERK phosphorylation and Gl/S cell cycle progression.	RAF1 ARAF	9.91e-06	2	110	2	15856007
Pubmed	Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization.	RAF1 BRAF	9.91e-06	2	110	2	16364920
Pubmed	K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling.	RAF1 ARAF BRAF	1.09e-05	14	110	3	31015455
Pubmed	Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development.	RAF1 ARAF BRAF	1.09e-05	14	110	3	28073913
Pubmed	Development of a diagnostic genetic test for simplex and autosomal recessive retinitis pigmentosa.	NR2E3 CRB1 USH2A	2.43e-05	18	110	3	20591486
Pubmed	Cross-talk between EphA2 and BRaf/CRaf is a key determinant of response to Dasatinib.	RAF1 BRAF	2.97e-05	3	110	2	24486585
Pubmed	The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases.	RAF1 BRAF	2.97e-05	3	110	2	10454553
Pubmed	Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling.	RAF1 BRAF	2.97e-05	3	110	2	22510884
Pubmed	R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis.	RSPO3 RSPO2	2.97e-05	3	110	2	15469841
Pubmed	B- and C-RAF display essential differences in their binding to Ras: the isotype-specific N terminus of B-RAF facilitates Ras binding.	RAF1 BRAF	2.97e-05	3	110	2	17635919
Pubmed	Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.	RAF1 BRAF	2.97e-05	3	110	2	20141835
Pubmed	ERK and PDE4 cooperate to induce RAF isoform switching in melanoma.	RAF1 BRAF	2.97e-05	3	110	2	21478863
Pubmed	Regulation of neonatal IgA production by the maternal microbiota.	TLR5 RORC	2.97e-05	3	110	2	33619092
Pubmed	Cell signaling through the protein kinases cAMP-dependent protein kinase, protein kinase Cepsilon, and RAF-1 regulates amphotropic murine leukemia virus envelope protein-induced syncytium formation.	RAF1 PRKCE	2.97e-05	3	110	2	15741175
Pubmed	RAF1/BRAF dimerization integrates the signal from RAS to ERK and ROKα.	RAF1 BRAF	2.97e-05	3	110	2	28270557
Pubmed	Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia.	RAF1 BRAF	2.97e-05	3	110	2	22169110
Pubmed	CRAF gene fusions in pediatric low-grade gliomas define a distinct drug response based on dimerization profiles.	RAF1 BRAF	2.97e-05	3	110	2	28806393
Pubmed	Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.	RAF1 BRAF	2.97e-05	3	110	2	23934108
Pubmed	Sorafenib inhibits non-small cell lung cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells.	RAF1 BRAF	2.97e-05	3	110	2	19638574
Pubmed	Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation.	RAF1 ARAF	2.97e-05	3	110	2	20052757
Pubmed	RSPOs facilitated HSC activation and promoted hepatic fibrogenesis.	RSPO3 RSPO2	2.97e-05	3	110	2	27572318
Pubmed	ERK and beyond: insights from B-Raf and Raf-1 conditional knockouts.	RAF1 BRAF	2.97e-05	3	110	2	16861903
Pubmed	Recurrent R-spondin fusions in colon cancer.	RSPO3 RSPO2	2.97e-05	3	110	2	22895193
Pubmed	Inhibitory actions of ceramide upon PKC-epsilon/ERK interactions.	RAF1 PRKCE	2.97e-05	3	110	2	11350735
Pubmed	C-Raf is required for the initiation of lung cancer by K-Ras(G12D).	RAF1 BRAF	2.97e-05	3	110	2	22043453
Pubmed	A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrome Activates the RAF-ERK Pathway.	RAF1 BRAF	2.97e-05	3	110	2	31024343
Pubmed	Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling.	RAF1 BRAF	2.97e-05	3	110	2	25155755
Pubmed	Modulation of kinase activity and oncogenic properties by alternative splicing reveals a novel regulatory mechanism for B-Raf.	RAF1 BRAF	2.97e-05	3	110	2	9733801
Pubmed	Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization.	RAF1 BRAF	2.97e-05	3	110	2	19710016
Pubmed	A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP).	CHRM4 OXTR TACR3	3.93e-05	21	110	3	15452121
Pubmed	The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation.	RSPO4 RSPO3 RSPO2	3.93e-05	21	110	3	26655896
Cytoband	18q22.3	CNDP2 FBXO15	5.96e-04	15	111	2	18q22.3
Cytoband	Ensembl 112 genes in cytogenetic band chrXq13	FAM236D FAM236B FAM236A FAM236C	7.14e-04	165	111	4	chrXq13
Cytoband	3p25	RAF1 OXTR	7.69e-04	17	111	2	3p25
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZBTB38 ZNF460 ZNF521 ZNF101 ZNF302 ZNF623 ZNF14 ZNF17 ZNF800 ZNF469 WIZ ZNF330 ZNF540 ZBTB21 ZNF770 PLAGL2 ZNF561 ZFP92 PRDM15 ZNF653 ZNF292	6.83e-12	718	83	21	28
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	RAF1 ARAF BRAF	9.27e-07	5	83	3	1157
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	RAF1 ARAF BRAF	1.76e-04	24	83	3	654
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Thalamus / BrainAtlas - Mouse McCarroll V32	HS3ST5 OXTR AGTR2 RSPO2 LHX5 TACR3 GREM1	8.66e-08	148	110	7	afebb64365c94b9476494bffe7c364677f19c8cf
ToppCell	Thalamus-Neuronal-Inhibitory\|Thalamus / BrainAtlas - Mouse McCarroll V32	HS3ST5 OXTR AGTR2 RSPO2 LHX5 TACR3 GREM1	8.66e-08	148	110	7	5f82e5ecacfd223020b8ee975c17d68c1fe6db38
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-midbrain/hindbrain_cells\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	CACNA1D HS3ST5 RYR3 TLR5 LHX5 TACR3	2.33e-06	154	110	6	df1b58a20af73fa79c6c069c0117a9ffd85b476f
ToppCell	343B-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CACNA1D FAM72D FAM72C RYR3 SLC22A16 FAM72B	4.26e-06	171	110	6	4ccd88cf812dd8bfdc55159c6f504e9c84e4f4fc
ToppCell	(0)_MSCs\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	DENND2B RSPO3 PLPP3 IFITM3 RSPO2 GREM1	6.90e-06	186	110	6	a832c1e0035bcd559722eccf262c145deb3494c7
ToppCell	(0)_MSCs-(00)_Lepr-MSC\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	DENND2B RSPO3 PLPP3 IFITM3 RSPO2 GREM1	6.90e-06	186	110	6	f0d156167d7cc2cd8a76e5a364233e9f2170bc01
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TSPAN12 GPR20 DENND2B KCNH2 AGTR2 RSPO2	8.53e-06	193	110	6	a402e736440684ebe123673b6b0c6fcd8fa057b2
ToppCell	15-Trachea-RBC-RBC\|Trachea / Age, Tissue, Lineage and Cell class	FAM72D FAM72C CCRL2 APOBEC3B SLC22A16 KCNH2	9.31e-06	196	110	6	511bfc06c34d5add2ae561cca463d1e4e2d43e20
ToppCell	15-Trachea-RBC\|Trachea / Age, Tissue, Lineage and Cell class	FAM72D FAM72C CCRL2 APOBEC3B SLC22A16 KCNH2	9.31e-06	196	110	6	bf2670e5ae996a19987bc70aa5a37d133db789eb
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GPR20 DENND2B IFITM3 KCNH2 AGTR2 RSPO2	9.58e-06	197	110	6	398a66c06df63567b176ab2cc85e27837e94d0d9
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TSPAN12 GPR20 DENND2B IFITM3 AGTR2 RSPO2	9.58e-06	197	110	6	888f3b14133e078570ce4ad73d9a9ee3137f9cac
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TSPAN12 ZNF521 RYR3 PLPP3 GPR75 RSPO2	1.01e-05	199	110	6	a900ef002e1ae583b70be0253d8c44dae6754916
Disease	Noonan syndrome with multiple lentigines	RAF1 BRAF	3.47e-05	3	101	2	cv:C0175704
Disease	Coronary Stenosis	HRH2 PRKCE	6.93e-05	4	101	2	C0242231
Disease	Sleep Disorders, Circadian Rhythm	CRY1 RORC	1.15e-04	5	101	2	C0877792
Disease	Delayed Sleep Phase Syndrome	CRY1 RORC	1.15e-04	5	101	2	C0393770
Disease	Shift-Work Sleep Disorder	CRY1 RORC	1.15e-04	5	101	2	C0751760
Disease	Non-24 Hour Sleep-Wake Disorder	CRY1 RORC	1.15e-04	5	101	2	C0751759
Disease	Advanced Sleep Phase Syndrome	CRY1 RORC	1.15e-04	5	101	2	C0751758
Disease	Nonorganic Sleep Wake Cycle Disorders	CRY1 RORC	1.15e-04	5	101	2	C0494410
Disease	Carcinoma, Lobular	MYH9 AGTR2	1.72e-04	6	101	2	C0206692
Disease	Leopard Syndrome 1	RAF1 BRAF	1.72e-04	6	101	2	C4551484
Disease	Pilomyxoid astrocytoma	RAF1 BRAF	2.41e-04	7	101	2	C1519086
Disease	Noonan syndrome	RAF1 BRAF	4.11e-04	9	101	2	cv:C0028326
Disease	high grade glioma (implicated_via_orthology)	RAF1 ARAF BRAF	4.66e-04	44	101	3	DOID:3070 (implicated_via_orthology)
Disease	Breast Carcinoma	RAF1 MYH9 H6PD APOBEC3B ARAF RSPO3 ALKBH8 BRAF	5.32e-04	538	101	8	C0678222
Disease	Noonan Syndrome 1	RAF1 BRAF	6.25e-04	11	101	2	C4551602
Disease	Turner Syndrome, Male	RAF1 BRAF	6.25e-04	11	101	2	C0041409
Disease	Female Pseudo-Turner Syndrome	RAF1 BRAF	6.25e-04	11	101	2	C1527404
Disease	Global developmental delay	SZT2 TMEM94 ALKBH8 LNPK	1.15e-03	133	101	4	C0557874
Disease	RASopathy	RAF1 BRAF	1.18e-03	15	101	2	cv:C5555857
Disease	N-acetyl-beta-alanine measurement	RYR3 VPS35L	1.35e-03	16	101	2	EFO_0021430
Disease	cardiomyopathy (implicated_via_orthology)	RAF1 ARAF BRAF	1.88e-03	71	101	3	DOID:0050700 (implicated_via_orthology)
Disease	Noonan-Like Syndrome With Loose Anagen Hair	RAF1 BRAF	1.91e-03	19	101	2	C3501846
Disease	Noonan syndrome-like disorder with loose anagen hair	RAF1 BRAF	1.91e-03	19	101	2	C1843181
Disease	Cardio-facio-cutaneous syndrome	RAF1 BRAF	1.91e-03	19	101	2	C1275081
Disease	Costello syndrome (disorder)	RAF1 BRAF	1.91e-03	19	101	2	C0587248
Disease	Retinitis pigmentosa	NR2E3 CRB1 USH2A	2.12e-03	74	101	3	cv:C0035334
Disease	prostate adenocarcinoma (is_implicated_in)	RAF1 BRAF	2.12e-03	20	101	2	DOID:2526 (is_implicated_in)
Disease	alpha-tocopherol measurement	PRKCE USH2A	2.12e-03	20	101	2	EFO_0007898
Disease	Mammary Carcinoma, Human	RAF1 MYH9 H6PD APOBEC3B ARAF RSPO3 ALKBH8	2.21e-03	525	101	7	C4704874
Disease	Mammary Neoplasms, Human	RAF1 MYH9 H6PD APOBEC3B ARAF RSPO3 ALKBH8	2.21e-03	525	101	7	C1257931
Disease	Mammary Neoplasms	RAF1 MYH9 H6PD APOBEC3B ARAF RSPO3 ALKBH8	2.26e-03	527	101	7	C1458155
Disease	cancer (implicated_via_orthology)	TSPAN12 RAF1 ARAF TSPAN5 BRAF	2.32e-03	268	101	5	DOID:162 (implicated_via_orthology)
Disease	LEOPARD Syndrome	RAF1 BRAF	2.56e-03	22	101	2	C0175704
Disease	Sensorineural Hearing Loss (disorder)	MYH9 TMC1	2.80e-03	23	101	2	C0018784
Disease	basophil percentage of granulocytes	RGMB ZNF101 ZNF469	2.93e-03	83	101	3	EFO_0007995
Disease	trans fatty acid measurement, trans/trans-18:2 fatty acid measurement	CACNA1D RYR3	3.05e-03	24	101	2	EFO_0006821, EFO_0006826
Disease	Noonan Syndrome	RAF1 BRAF	3.05e-03	24	101	2	C0028326
Disease	Acute kidney injury	TLR5 TACR3	3.31e-03	25	101	2	HP_0001919

Protein segments in the cluster

Peptide	Gene	Start	Entry
ACYALCNATFKKTFR	CHRM4	451	P08173
RFFNAFCYCRKLGTA	AGRP	111	O00253
AFCDFCRKLLFQGFR	BRAF	246	P15056
YRGASAAFCIQLFCI	CFAP61	381	Q8NHU2
AFLDGTFSKYLCRCF	CCRL2	301	O00421
GFLCNEAKNLLCGFY	APOBEC3B	236	Q9UH17
FTFRKVRQTPCNCSY	ALKBH8	331	Q96BT7
RRLCFFYNKKSDVGF	AFM	121	P43652
NGLALYVFCCRTRAK	GPR20	71	Q99678
FLYCFVGNRFQQKLR	AGTR2	316	P50052
QRLYGTRCFSCDQFI	ABLIM2	76	Q6H8Q1
YCVISRLGCFGLFSK	DENND2B	796	P78524
SCTIGFYCRNVQDFK	ATG4C	381	Q96DT6
AYCPLVLKFQFCSRA	ADAMTS10	1076	Q9H324
QKFLLNGFRCQTCGY	RAF1	156	P04049
IYACNGCSGFFKRSV	NR2E3	61	Q9Y5X4
YLFNCTARGRNVCKF	LRP11	161	Q86VZ4
RTIINRFCYGQCNSF	GREM1	111	O60565
NAVDFTGRCYFTKIC	FAM72D	51	Q6L9T8
CCLGFIAFAYSVKSR	IFITM3	71	Q01628
QLYCCFQTKDRLFFV	PRKCE	471	Q02156
IAFYRKDGSCFLCLV	KCNH2	96	Q12809
CCAQQRTYEKFFGLL	CWC22	496	Q9HCG8
KNQLGFLRFANYCRI	DCAF4L2	31	Q8NA75
GSFFLCKIRECVLNY	LINC02901	86	Q4VX62
LFSCAGSNTKYRRLC	MGAT5B	761	Q3V5L5
QFLQYHGKILCFFCL	EFHC2	221	Q5JST6
GFYCLRFNIIFNKCL	HS3ST5	291	Q8IZT8
GLCSSQKLQLFYFCF	OR4K5	16	Q8NGD3
RALACFTKCFRGGYR	FAM236A	61	A0A1B0GUQ0
LNRDFRTGYQQLFCC	HRH2	291	P25021
TRKTARQPNCYLFFC	MANSC1	86	Q9H8J5
YCKNDFFRRFGTKCA	LHX5	51	Q9H2C1
QRFQGIYRCFASNKL	L1CAM	106	P32004
FQACCRGYLARKAFA	MYH9	786	P35579
NAVDFTGRCYFTKIC	FAM72A	51	Q5TYM5
VQRFLCCSASYLKGR	OXTR	341	P30559
LQYIGLGFFCCKQKT	GPR75	391	O95800
CFYVIGFLLFKNRSC	OR12D3	216	Q9UGF7
LKFLFHGFRCQTCGY	ARAF	116	P10398
CCLGFIAFAYSVKSR	nan	71	C9JQL5
PCDLKQCQAAIRFFY	GFRAL	161	Q6UXV0
RALACFTKCFRGGYR	FAM236B	61	A0A1B0GV22
FYLCGTFRNLFTKRG	FBXO15	366	Q8NCQ5
NAVDFTGRCYFTKIC	FAM72C	51	H0Y354
RFGCLSCRLFYFKLT	CRY1	256	Q16526
FFKFCYQCGRSIGVR	ANKMY1	876	Q9P2S6
VFQKQFYRLGGFRVC	LYST	976	Q99698
FKVCRQDSFRCLYPQ	INSC	286	Q1MX18
KRFCFLTCDAASYLG	FRY	2716	Q5TBA9
YSCLCFGNFTGKFCR	CRB1	1236	P82279
RALACFIKCFRGGYR	FAM236C	61	P0DP71
RALACFIKCFRGGYR	FAM236D	61	A0A1B0GTK5
VGYARILFKNQACCV	H6PD	366	O95479
RCLCAGYFKNVARRS	DHX40	621	Q8IX18
CIGVQLFKGKFYRCT	CACNA1D	1031	Q01668
NAVDFTGRCYFTKIC	FAM72B	51	Q86X60
GLLACKVTAYIFFCN	GPR132	111	Q9UNW8
QTGKRACCAFYSRNI	RTL1	896	A6NKG5
LAFQGCYFCVKQFAL	SZT2	2996	Q5T011
CYFCVKQFALECSRI	SZT2	3001	Q5T011
NCELCKDYFFRQVGA	USH2A	616	O75445
FCKALRAYAGCTQRT	RGMB	81	Q6NW40
QDFCIRCKRQFYLYK	RSPO4	101	Q2I0M5
LYKQVGCFLFGCAIS	PLPP3	126	O14495
RVLYFICAFQNISCG	SLC22A16	21	Q86VW1
GCSICNRRFALKATY	PRDM15	1021	P57071
CVACSKIFGRFSRRY	RUFY4	521	Q6ZNE9
GNIYTLKCRFCEVEF	WIZ	1591	O95785
TFEFCKRICLYQNGY	SLC25A43	286	Q8WUT9
YCCLNKRFRAGFKRA	TACR3	356	P29371
GCSRCQQKLFFFLRR	RSPO2	51	Q6UXX9
LFMCYGFCQQFVRKV	SLC25A2	81	Q9BXI2
RKDFLCQYCAQRFGR	PLAGL2	216	Q9UPG8
IGDFLRACFVRFCNY	TMC1	541	Q8TDI8
RGICYFFIEVECSNK	CNDP2	211	Q96KP4
QSLRPFCTVCNRYFK	CIZ1	681	Q9ULV3
FCTVCNRYFKTPRKF	CIZ1	686	Q9ULV3
FVCKICGKAFLYSSR	ZNF561	421	Q8N587
RYLCQQCGKAFSRSS	ZFP92	151	A6NM28
EVQYNFTCDRCGKRF	ZNF653	581	Q96CK0
ICTYCGKAYRFLSQF	ZBTB21	671	Q9ULJ3
KCVRCGKTFRFGFYL	ZNF540	496	Q8NDQ6
VCNECGKAFTYRSNF	ZNF460	281	Q14592
KTAAFVRACVAYCFI	VPS35L	696	Q7Z3J2
AGFINYKICRLCFQH	TRAPPC11	271	Q7Z392
CKGFFRRSQRCNAAY	RORC	51	P51449
YALRVERFCCAVFAK	SLFN12L	321	Q6IEE8
LSLIFCCYFISKLRN	RNF122	51	Q9H9V4
TYGIRKCFLFLLQCQ	TMEM94	1086	Q12767
FLCYFCRISRQNQKA	RYR3	2096	Q15413
IKGNYKCNVCSRTFF	ZNF521	926	Q96K83
CRKCYMLDFGLARQF	TTBK2	156	Q6IQ55
RDGKFICSRCYRAFT	ZNF292	1371	O60281
YNGCLSCKPRLFFAL	RSPO3	51	Q9BXY4
NFFQREFKCCGVVYF	TSPAN12	151	O95859
FAALGAYNFCCRDII	PSME4	991	Q14997
DVFLYRCSVCAKSFR	ZNF770	621	Q6IQ21
SYKCKVCFQRFRSLG	ZNF469	3086	Q96JG9
VSCCIKYFIFGFNVI	TSPAN5	11	P62079
CKQCGKVFTFSNYLR	ZNF101	396	Q8IZC7
CFSAYKRENRCSFIL	ZSWIM3	16	Q96MP5
FDFKQLYCKLCKRQF	ZNF800	481	Q2TB10
NRAFCYFCNSVQKLP	ZNF330	51	Q9Y3S2
QLFCQKYFSCGRESF	ZMYM1	481	Q5SVZ6
CQFCFQRFLYLSTKR	ZBTB38	1096	Q8NAP3
CSYCGKGFIQRSNFL	ZNF623	461	O75123
TKFRGFCFICYKTAQ	TLR5	661	O60602
FCFICYKTAQRLVFK	TLR5	666	O60602
GLFFLYCKQFFNRHC	EDA2R	156	Q9HAV5
KCGKFFRYCFTLNRH	ZNF17	446	P17021
CVQGTNKVYFKQFCR	ZAR1	346	Q86SH2
KQCGKAFICYQSFQR	ZNF14	226	P17017
QCGKAFRCSSYFRIH	ZNF14	451	P17017
RQCFAFLIYFRLGIK	ZNF302	141	Q9NR11
FRCAYCFFLNPARKT	LNPK	296	Q9C0E8