Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	1-phosphatidylinositol-4-phosphate 3-kinase activity	PIK3C2A PIK3CB	6.60e-05	7	36	2	GO:0035005
GeneOntologyMolecularFunction	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	PIK3C2A PIK3CB	6.60e-05	7	36	2	GO:0046934
GeneOntologyMolecularFunction	1-phosphatidylinositol-3-kinase activity	PIK3C2A PIK3CB	1.72e-04	11	36	2	GO:0016303
Domain	Beta-TrCP_D	BTRC FBXW11	3.61e-06	2	36	2	IPR021977
Domain	Beta-TrCP_D	BTRC FBXW11	3.61e-06	2	36	2	PF12125
Domain	Beta-TrCP_D	BTRC FBXW11	3.61e-06	2	36	2	SM01028
Domain	PI3K_Ras-bd_dom	PIK3C2A PIK3CB	7.54e-05	7	36	2	IPR000341
Domain	PI3K_RBD	PIK3C2A PIK3CB	7.54e-05	7	36	2	PS51546
Domain	PI3K_rbd	PIK3C2A PIK3CB	7.54e-05	7	36	2	SM00144
Domain	PI3K_rbd	PIK3C2A PIK3CB	7.54e-05	7	36	2	PF00794
Domain	PI3K_C2_dom	PIK3C2A PIK3CB	1.00e-04	8	36	2	IPR002420
Domain	PI3K_C2	PIK3C2A PIK3CB	1.00e-04	8	36	2	PS51547
Domain	PI3K_C2	PIK3C2A PIK3CB	1.00e-04	8	36	2	SM00142
Domain	PI3K_C2	PIK3C2A PIK3CB	1.00e-04	8	36	2	PF00792
Domain	PI3Ka	PIK3C2A PIK3CB	1.29e-04	9	36	2	PF00613
Domain	-	PIK3C2A PIK3CB	1.29e-04	9	36	2	1.25.40.70
Domain	PI3Ka	PIK3C2A PIK3CB	1.29e-04	9	36	2	SM00145
Domain	PIK_HELICAL	PIK3C2A PIK3CB	1.61e-04	10	36	2	PS51545
Domain	PI_Kinase	PIK3C2A PIK3CB	1.61e-04	10	36	2	IPR015433
Domain	PInositide-3_kin_accessory_dom	PIK3C2A PIK3CB	1.61e-04	10	36	2	IPR001263
Domain	PI3/4_kinase_CS	PIK3C2A PIK3CB	3.73e-04	15	36	2	IPR018936
Domain	PI3Kc	PIK3C2A PIK3CB	4.26e-04	16	36	2	SM00146
Domain	-	PIK3C2A PIK3CB	4.26e-04	16	36	2	1.10.1070.11
Domain	PI3_4_KINASE_1	PIK3C2A PIK3CB	5.42e-04	18	36	2	PS00915
Domain	PI3_4_KINASE_2	PIK3C2A PIK3CB	5.42e-04	18	36	2	PS00916
Domain	PI3/4_kinase_cat_dom	PIK3C2A PIK3CB	5.42e-04	18	36	2	IPR000403
Domain	PI3_PI4_kinase	PIK3C2A PIK3CB	5.42e-04	18	36	2	PF00454
Domain	PI3_4_KINASE_3	PIK3C2A PIK3CB	5.42e-04	18	36	2	PS50290
Domain	NACHT	NLRC5 NLRP10	8.91e-04	23	36	2	PS50837
Domain	NACHT_NTPase	NLRC5 NLRP10	8.91e-04	23	36	2	IPR007111
Domain	F-box-like	BTRC FBXW11	3.25e-03	44	36	2	PF12937
Domain	Kinase-like_dom	FES NPR2 STKLD1 PIK3C2A PIK3CB	3.62e-03	542	36	5	IPR011009
Domain	ARM-type_fold	STKLD1 PIK3C2A GCN1 PIK3CB	3.97e-03	339	36	4	IPR016024
Domain	FBOX	BTRC FBXW11	4.51e-03	52	36	2	SM00256
Domain	F-box	BTRC FBXW11	7.38e-03	67	36	2	PF00646
Domain	FBOX	BTRC FBXW11	8.48e-03	72	36	2	PS50181
Domain	F-box_dom	BTRC FBXW11	9.18e-03	75	36	2	IPR001810
Domain	G-protein_beta_WD-40_rep	BTRC FBXW11	1.17e-02	85	36	2	IPR020472
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ST3GAL4 ADAMTS13 B3GNT5 LARGE1	6.92e-05	109	29	4	MM15164
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ST3GAL4 ADAMTS13 B3GNT5 LARGE1	7.43e-05	111	29	4	M27416
Pathway	KEGG_MEDICUS_PATHOGEN_SHIGELLA_OSPG_TO_TNF_NFKB_SIGNALING_PATHWAY	BTRC FBXW11	8.53e-05	7	29	2	M47653
Pathway	WP_NEOLACTO_SERIES_SPHINGOLIPID_METABOLISM	ST3GAL4 B3GNT5	2.22e-04	11	29	2	M48314
Pubmed	Identification of substrates for F-box proteins.	CCNE1 BTRC FBXW11	3.87e-08	7	37	3	16338364
Pubmed	Specificity, location and function of βTrCP isoforms and their splice variants.	BTRC FBXW11	1.10e-06	2	37	2	21138764
Pubmed	The characteristics and roles of β-TrCP1/2 in carcinogenesis.	BTRC FBXW11	1.10e-06	2	37	2	33021036
Pubmed	Differential dysregulation of β-TrCP1 and -2 by HIV-1 Vpu leads to inhibition of canonical and non-canonical NF-κB pathways in infected cells.	BTRC FBXW11	1.10e-06	2	37	2	37341489
Pubmed	The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth.	BTRC FBXW11	3.30e-06	3	37	2	31406304
Pubmed	Silencing of both beta-TrCP1 and HOS (beta-TrCP2) is required to suppress human immunodeficiency virus type 1 Vpu-mediated CD4 down-modulation.	BTRC FBXW11	3.30e-06	3	37	2	17121803
Pubmed	Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase.	BTRC FBXW11	3.30e-06	3	37	2	23640883
Pubmed	Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase.	BTRC FBXW11	3.30e-06	3	37	2	28483528
Pubmed	Critical role for IL-1β in DNA damage-induced mucositis.	BTRC FBXW11	3.30e-06	3	37	2	24469832
Pubmed	The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2.	BTRC FBXW11	3.30e-06	3	37	2	18782782
Pubmed	Stability of Wake-Sleep Cycles Requires Robust Degradation of the PERIOD Protein.	BTRC FBXW11	3.30e-06	3	37	2	29103939
Pubmed	Persistent stimulation with interleukin-17 desensitizes cells through SCFβ-TrCP-mediated degradation of Act1.	BTRC FBXW11	3.30e-06	3	37	2	22045853
Pubmed	The ubiquitin ligase subunit β-TrCP in Sertoli cells is essential for spermatogenesis in mice.	BTRC FBXW11	3.30e-06	3	37	2	30391586
Pubmed	SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation.	BTRC FBXW11	3.30e-06	3	37	2	18354483
Pubmed	The Tumor Suppressor MIG6 Controls Mitotic Progression and the G2/M DNA Damage Checkpoint by Stabilizing the WEE1 Kinase.	BTRC FBXW11	6.60e-06	4	37	2	30067982
Pubmed	β-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress.	BTRC FBXW11	6.60e-06	4	37	2	30031111
Pubmed	Oxidative stress-induced ubiquitination of RCAN1 mediated by SCFbeta-TrCP ubiquitin ligase.	BTRC FBXW11	6.60e-06	4	37	2	18575781
Pubmed	S6 Kinase- and β-TrCP2-Dependent Degradation of p19Arf Is Required for Cell Proliferation.	BTRC FBXW11	6.60e-06	4	37	2	26240281
Pubmed	Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase.	BTRC FBXW11	6.60e-06	4	37	2	16651270
Pubmed	SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.	BTRC FBXW11	6.60e-06	4	37	2	16885022
Pubmed	Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1.	BTRC FBXW11	6.60e-06	4	37	2	26768845
Pubmed	Multiple isoforms of beta-TrCP display differential activities in the regulation of Wnt signaling.	BTRC FBXW11	6.60e-06	4	37	2	18929646
Pubmed	PLK1 and β-TrCP-dependent ubiquitination and degradation of Rap1GAP controls cell proliferation.	BTRC FBXW11	6.60e-06	4	37	2	25329897
Pubmed	Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis.	BTRC FBXW11	6.60e-06	4	37	2	19270156
Pubmed	SCFβ(TrCP) mediates stress-activated MAPK-induced Cdc25B degradation.	BTRC FBXW11	1.10e-05	5	37	2	21807946
Pubmed	Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing.	BTRC FBXW11	1.10e-05	5	37	2	14673179
Pubmed	Regulation of mitosis-meiosis transition by the ubiquitin ligase β-TrCP in male germ cells.	BTRC FBXW11	1.10e-05	5	37	2	28982686
Pubmed	Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9.	BTRC FBXW11	1.10e-05	5	37	2	25190485
Pubmed	Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner.	BTRC FBXW11	1.10e-05	5	37	2	15798217
Pubmed	Revealing β-TrCP activity dynamics in live cells with a genetically encoded biosensor.	BTRC FBXW11	1.10e-05	5	37	2	36289220
Pubmed	SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.	BTRC FBXW11	1.10e-05	5	37	2	14681206
Pubmed	IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2.	BTRC FBXW11	1.10e-05	5	37	2	10066435
Pubmed	Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination.	BTRC FBXW11	1.65e-05	6	37	2	10644755
Pubmed	TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex.	BTRC FBXW11	1.65e-05	6	37	2	17636028
Pubmed	SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection.	BTRC FBXW11	1.65e-05	6	37	2	17217622
Pubmed	Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization.	BTRC FBXW11	1.65e-05	6	37	2	17387146
Pubmed	Detection of sequential polyubiquitylation on a millisecond timescale.	CCNE1 BTRC	1.65e-05	6	37	2	19956254
Pubmed	Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha.	BTRC FBXW11	1.65e-05	6	37	2	11158290
Pubmed	Fas-associated factor 1 is a scaffold protein that promotes β-transducin repeat-containing protein (β-TrCP)-mediated β-catenin ubiquitination and degradation.	BTRC FBXW11	1.65e-05	6	37	2	22730322
Pubmed	betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.	BTRC FBXW11	1.65e-05	6	37	2	12482991
Pubmed	Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis.	BTRC FBXW11	1.65e-05	6	37	2	18056411
Pubmed	The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival.	BTRC FBXW11	1.65e-05	6	37	2	19966869
Pubmed	USP17- and SCFβTrCP--regulated degradation of DEC1 controls the DNA damage response.	BTRC FBXW11	2.30e-05	7	37	2	25202122
Pubmed	The p97-UFD1L-NPL4 protein complex mediates cytokine-induced IκBα proteolysis.	BTRC FBXW11	2.30e-05	7	37	2	24248593
Pubmed	Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication.	CCNE1 BTRC	2.30e-05	7	37	2	10790373
Pubmed	ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4.	BTRC FBXW11	2.30e-05	7	37	2	22307056
Pubmed	The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding.	BTRC FBXW11	2.30e-05	7	37	2	30143532
Pubmed	Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.	CCNE1 BTRC FBXW11	2.80e-05	55	37	3	37028429
Pubmed	betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.	BTRC FBXW11	3.07e-05	8	37	2	19150432
Pubmed	NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly.	CCNE1 BTRC	3.07e-05	8	37	2	32051583
Pubmed	SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2.	BTRC FBXW11	3.07e-05	8	37	2	22711876
Pubmed	Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress.	BTRC FBXW11	3.07e-05	8	37	2	22669845
Pubmed	SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.	BTRC FBXW11	3.07e-05	8	37	2	15917222
Pubmed	mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR.	BTRC FBXW11	3.07e-05	8	37	2	22017877
Pubmed	LSD1 destabilizes FBXW7 and abrogates FBXW7 functions independent of its demethylase activity.	CCNE1 BTRC	3.07e-05	8	37	2	31152129
Pubmed	Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins.	CCNE1 BTRC	3.07e-05	8	37	2	23453757
Pubmed	Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association.	ADAMTS13 STKLD1	3.07e-05	8	37	2	23267103
Pubmed	Proteasome-dependent degradation of transcription factor activating enhancer-binding protein 4 (TFAP4) controls mitotic division.	BTRC FBXW11	3.07e-05	8	37	2	24500709
Pubmed	CENP-W inhibits CDC25A degradation by destabilizing the SCFβ-TrCP-1 complex at G2/M.	BTRC FBXW11	3.95e-05	9	37	2	29863914
Pubmed	DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy.	BTRC FBXW11	3.95e-05	9	37	2	22017876
Pubmed	Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation.	CCNE1 BTRC	3.95e-05	9	37	2	18851830
Pubmed	Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.	BTRC FBXW11	3.95e-05	9	37	2	20708156
Pubmed	DNA sequence and analysis of human chromosome 9.	NPR2 ADAMTS13 STKLD1 TRPM3 INVS	4.37e-05	370	37	5	15164053
Pubmed	β-TrCP-mediated IRAK1 degradation releases TAK1-TRAF6 from the membrane to the cytosol for TAK1-dependent NF-κB activation.	BTRC FBXW11	4.93e-05	10	37	2	22851693
Pubmed	The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1.	PIK3C2A PIK3CB	4.93e-05	10	37	2	8636073
Pubmed	Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells.	PIK3C2A PIK3CB	4.93e-05	10	37	2	8798481
Pubmed	NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach.	BTRC FBXW11	4.93e-05	10	37	2	15485837
Pubmed	Expression of HIV-1 nef decreases basal phosphatidyl-inositol 3-kinase activity.	PIK3C2A PIK3CB	4.93e-05	10	37	2	9247029
Pubmed	Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.	CCNE1 BTRC	4.93e-05	10	37	2	31868589
Pubmed	Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.	BTRC FBXW11	4.93e-05	10	37	2	14603323
Pubmed	Cyclin F-Dependent Degradation of RBPJ Inhibits IDH1R132H-Mediated Tumorigenesis.	BTRC FBXW11	6.02e-05	11	37	2	30254149
Pubmed	Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination.	BTRC FBXW11	6.02e-05	11	37	2	24912152
Pubmed	HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells.	PIK3C2A PIK3CB	6.02e-05	11	37	2	9708406
Pubmed	Polyubiquitination of the B-cell translocation gene 1 and 2 proteins is promoted by the SCF ubiquitin ligase complex containing βTrCP.	BTRC FBXW11	6.02e-05	11	37	2	22975506
Pubmed	HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line.	PIK3C2A PIK3CB	6.02e-05	11	37	2	10985305
Pubmed	Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells.	PIK3C2A PIK3CB	6.02e-05	11	37	2	12584329
Pubmed	Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity.	PIK3C2A PIK3CB	6.02e-05	11	37	2	9808187
Pubmed	HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways.	PIK3C2A PIK3CB	6.02e-05	11	37	2	16081599
Pubmed	The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.	BTRC FBXW11	7.22e-05	12	37	2	18662541
Pubmed	HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation: dissociation of the CD4-p56(lck) complex and targeting of CD4 to lysosomes.	PIK3C2A PIK3CB	7.22e-05	12	37	2	10208934
Pubmed	Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells.	PIK3C2A PIK3CB	7.22e-05	12	37	2	14602571
Pubmed	Colony-stimulating factor-1 requires PI3-kinase-mediated metabolism for proliferation and survival in myeloid cells.	PIK3C2A PIK3CB	7.22e-05	12	37	2	16514418
Pubmed	Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism.	PIK3C2A PIK3CB	7.22e-05	12	37	2	12077252
Pubmed	Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity.	PIK3C2A PIK3CB	7.22e-05	12	37	2	9341793
Pubmed	Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.	BTRC FBXW11	7.22e-05	12	37	2	22682247
Pubmed	Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages.	PIK3C2A PIK3CB	7.22e-05	12	37	2	12551992
Pubmed	Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase.	BTRC FBXW11	7.22e-05	12	37	2	24785407
Pubmed	Control of chromosome stability by the beta-TrCP-REST-Mad2 axis.	BTRC FBXW11	7.22e-05	12	37	2	18354482
Pubmed	S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer.	BTRC FBXW11	8.53e-05	13	37	2	29507620
Pubmed	HIV-1 Nef in macrophage-mediated disease pathogenesis.	PIK3C2A PIK3CB	8.53e-05	13	37	2	23215766
Pubmed	TAK1 Is a Novel Target in Hepatocellular Carcinoma and Contributes to Sorafenib Resistance.	BTRC FBXW11	8.53e-05	13	37	2	33962073
Pubmed	Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells.	PIK3C2A PIK3CB	8.53e-05	13	37	2	9394803
Pubmed	WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins.	CCNE1 BTRC	9.94e-05	14	37	2	21070969
Pubmed	A central role for regulated protein stability in the control of TFE3 and MITF by nutrients.	BTRC FBXW11	9.94e-05	14	37	2	36608670
Pubmed	Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line.	PIK3C2A PIK3CB	9.94e-05	14	37	2	17157319
Pubmed	HIV Nef enhances Tat-mediated viral transcription through a hnRNP-K-nucleated signaling complex.	PIK3C2A PIK3CB	1.15e-04	15	37	2	18854243
Pubmed	Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma.	CCNE1 BTRC	1.31e-04	16	37	2	22388891
Pubmed	HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45.	PIK3C2A PIK3CB	1.31e-04	16	37	2	16524887
Pubmed	Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders.	PIK3C2A PIK3CB	1.31e-04	16	37	2	20818790
Pubmed	HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway.	PIK3C2A PIK3CB	1.31e-04	16	37	2	11289809
Interaction	MYO10 interactions	PIK3C2A TERF2 GCN1 BTRC FBXW11	4.28e-06	141	35	5	int:MYO10
Interaction	SKP1P2 interactions	BTRC FBXW11	8.78e-06	3	35	2	int:SKP1P2
GeneFamily	Phosphatidylinositol 3-kinase subunits	PIK3C2A PIK3CB	7.41e-05	8	30	2	831
GeneFamily	WD repeat domain containing\|F-box and WD repeat domain containing	BTRC FBXW11	1.45e-04	11	30	2	559
GeneFamily	NLR family	NLRC5 NLRP10	7.80e-04	25	30	2	666
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-mature_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR3 APOC4 SPRING1 SLC45A4	5.17e-06	138	37	4	321070b6900887b27da0f2b25808a05a8ab89ee7
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-BM_CD8_+_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR3 APOC4 SPRING1 SLC45A4	5.17e-06	138	37	4	19ffd66256fa94d728138d37d0a5a3bac7722dbb
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l48\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RUFY2 NLRC5 CXCR3 KATNAL1	1.18e-05	170	37	4	070d8683d1a5cc7d594ff0453c961a9bf982c2d0
ToppCell	metastatic_Brain-Myeloid_cells-CD141+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	NLRC5 CXCR3 NPR2 NUBPL	1.29e-05	174	37	4	5ec8a48a390379d6c422120dce46437a77da67cc
ToppCell	Caecum-Dendritic_cell-cDC1\|Dendritic_cell / Region, Cell class and subclass	CXCR3 KATNAL1 GMEB2 NUBPL	1.35e-05	176	37	4	07cde50e1c18fcc2c5028efe1a087db4ef4d4783
Drug	Piromidic acid [19562-30-2]; Up 200; 13.8uM; PC3; HT_HG-U133A	NPR2 ST3GAL4 ACSBG1 BTRC LARGE1	1.30e-05	194	36	5	4575_UP
Drug	Tiaprofenic acid [33005-95-7]; Up 200; 15.4uM; MCF7; HT_HG-U133A	NPR2 APOC4 ACSBG1 PRLH KLHDC8A	1.43e-05	198	36	5	4171_UP
Drug	Zaprinast [37762-06-4]; Up 200; 14.8uM; MCF7; HT_HG-U133A	ADAMTS13 ACSBG1 PRLH BTRC KLHDC8A	1.47e-05	199	36	5	3226_UP
Disease	aspartate aminotransferase measurement	CCNE1 NLRC5 ST3GAL4 STKLD1 TRPM3 GCN1 RAB3IL1 SLC45A4	1.06e-05	904	36	8	EFO_0004736
Disease	free cholesterol to total lipids in large VLDL percentage	NLRC5 ST3GAL4 APOC4	1.26e-05	37	36	3	EFO_0022281
Disease	Menkes disease (implicated_via_orthology)	BTRC FBXW11	1.44e-05	5	36	2	DOID:1838 (implicated_via_orthology)
Disease	triglycerides to total lipids in large VLDL percentage	NLRC5 ST3GAL4 APOC4	1.48e-05	39	36	3	EFO_0022332
Disease	cholesteryl esters to total lipids in small VLDL percentage	NLRC5 ST3GAL4 APOC4	2.96e-05	49	36	3	EFO_0022256
Disease	von Willebrand factor measurement	ST3GAL4 ADAMTS13 STKLD1	4.42e-05	56	36	3	EFO_0004629
Disease	CD209 antigen measurement	ADAMTS13 STKLD1	1.30e-04	14	36	2	EFO_0008077
Disease	a disintegrin and metalloproteinase with thrombospondin motifs 13 measurement	ADAMTS13 STKLD1	1.95e-04	17	36	2	EFO_0008011
Disease	angiopoietin-1 receptor measurement	ST3GAL4 STKLD1	2.44e-04	19	36	2	EFO_0010600
Disease	cholesteryl ester measurement	NLRC5 ST3GAL4 APOC4 RAB3IL1	2.66e-04	257	36	4	EFO_0010351
Disease	apolipoprotein A 1 measurement, apolipoprotein B measurement	NLRC5 ST3GAL4 APOC4	3.03e-04	107	36	3	EFO_0004614, EFO_0004615
Disease	e-selectin measurement	ST3GAL4 STKLD1	3.29e-04	22	36	2	EFO_0004575
Disease	ganglion cell inner plexiform layer thickness measurement	PIK3C2A INVS	5.36e-04	28	36	2	EFO_0600005
Disease	cholesteryl esters to total lipids in large LDL percentage	NLRC5 APOC4	6.58e-04	31	36	2	EFO_0022249
Disease	low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	NLRC5 ST3GAL4 APOC4	8.61e-04	153	36	3	EFO_0004611, EFO_0020946
Disease	obsolete_red blood cell distribution width	CCNE1 NPR2 APOC4 STKLD1 ACSBG1 BTRC EPG5	1.06e-03	1347	36	7	EFO_0005192
Disease	factor VIII measurement	ST3GAL4 STKLD1	1.10e-03	40	36	2	EFO_0004630
Disease	high density lipoprotein particle size measurement	NLRC5 ST3GAL4 APOC4	1.17e-03	170	36	3	EFO_0008592
Disease	bipolar disorder, schizophrenia	NLRC5 PIK3C2A	1.21e-03	42	36	2	MONDO_0004985, MONDO_0005090
Disease	high grade glioma (implicated_via_orthology)	CXCR3 PIK3CB	1.33e-03	44	36	2	DOID:3070 (implicated_via_orthology)
Disease	cholesterol to total lipids in large VLDL percentage	NLRC5 APOC4	1.39e-03	45	36	2	EFO_0022236
Disease	fetal genotype effect measurement, body weights and measures	FES SLC45A4	1.64e-03	49	36	2	EFO_0004324, EFO_0007959
Disease	apolipoprotein B to apolipoprotein A1 ratio	NLRC5 ST3GAL4	1.64e-03	49	36	2	EFO_0021897
Disease	Malignant neoplasm of breast	CCNE1 NLRC5 APOC4 MIA2 PIK3CB EPG5	1.75e-03	1074	36	6	C0006142
Disease	phospholipids in medium VLDL measurement	ST3GAL4 APOC4	1.85e-03	52	36	2	EFO_0022154
Disease	systemic scleroderma (is_marker_for)	CXCR3 ADAMTS13	1.92e-03	53	36	2	DOID:418 (is_marker_for)
Disease	phospholipids in medium HDL measurement	NLRC5 APOC4	2.06e-03	55	36	2	EFO_0022295
Disease	free cholesterol to total lipids in very large HDL percentage	ST3GAL4 APOC4	2.06e-03	55	36	2	EFO_0022288
Disease	free cholesterol in medium HDL measurement	NLRC5 APOC4	2.29e-03	58	36	2	EFO_0022267
Disease	total lipids in medium HDL measurement	NLRC5 APOC4	2.29e-03	58	36	2	EFO_0022310
Disease	cholesterol in medium HDL measurement	NLRC5 APOC4	2.37e-03	59	36	2	EFO_0021903
Disease	phospholipids in small VLDL measurement	ST3GAL4 APOC4	2.45e-03	60	36	2	EFO_0022146
Disease	retinal layer thickness measurement	PIK3C2A INVS	2.45e-03	60	36	2	EFO_0600002
Disease	free cholesterol in HDL measurement	NLRC5 APOC4	2.53e-03	61	36	2	EFO_0022264
Disease	phospholipids in HDL measurement	NLRC5 APOC4	2.53e-03	61	36	2	EFO_0022293
Disease	triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	NLRC5 ST3GAL4 APOC4	2.59e-03	225	36	3	EFO_0008317, EFO_0020947

Protein segments in the cluster

Peptide	Gene	Start	Entry
VGVKFRERMWMLLLR	CXCR3	321	P49682
LKAKRLGIWLFMSEM	EPG5	696	Q9HCE0
DGMLWKKLIERMVRT	BTRC	221	Q9Y297
ILTMELMIMKALKWR	CCNE1	226	P24864
LMIMKALKWRLSPLT	CCNE1	231	P24864
LMLEKELASMLWRIR	NPR2	481	P20594
KLKMSRWSLVRGRMK	APOC4	41	P55056
GRLTWRKMCRKLLDM	ADAMTS13	1246	Q76LX8
DWKRAIRMNGIMLRK	GMEB2	141	Q9UKD1
WEIMRLRKEMSLAKL	RAB3IL1	361	Q8TBN0
LLLLDKLRKMKWEQM	LARGE1	301	O95461
MAMAKARKPREALLW	NLRP10	1	Q86W26
LRNAEMRKAMKRLWI	OR4X2	281	Q8NGF9
MRKAMKRLWIRTLRL	OR4X2	286	Q8NGF9
MDKIWLKEGLDLRMV	PIK3C2A	1156	O00443
GMLWKKLIERMVRTD	FBXW11	161	Q9UKB1
IRKLAERLWSMMGLD	GCN1	1141	Q92616
ALMRALEGKWMLKRL	NLRC5	1541	Q86WI3
MRMLVSGRRVKKWQL	B3GNT5	1	Q9BYG0
LFMLMALVLLQRKLW	FCAMR	461	Q8WWV6
IRRKMLLWAMSVTLE	ACSBG1	396	Q96GR2
KWKKRSMLREAAMGI	KLHDC8A	106	Q8IYD2
KWNLHKRIALRMVLM	SLC13A4	101	Q9UKG4
WRGLMVMSAIEKLLR	NUBPL	156	Q8TB37
SLRNSEMKRALMKLW	OR10A6	291	Q8NH74
FMKLLLTRRANWMQK	INVS	96	Q9Y283
TERLLKMKDWAAMLG	MIA2	876	Q96PC5
EAELRLLEGMRKWMA	FES	21	P07332
LLEGMRKWMAQRVKS	FES	26	P07332
AKKLLREAVVLPMWM	KATNAL1	216	Q9BW62
MVNLAAMVWRRLLRK	SPRING1	1	Q9H741
RAWLRLALMQKKMAD	RUFY2	106	Q8WXA3
MVSKSRWKLLAMLAL	ST3GAL4	1	Q11206
TLQMLRLMDLLWKEA	PIK3CB	816	P42338
LLWLSMLKMPRELMR	SLC45A4	496	Q5BKX6
WPEVQLRAMKRLLKM	STKLD1	341	Q8NE28
WMGRLRMRKNSGLKV	TRPM3	786	Q9HCF6
MKVLRAWLLCLLMLG	PRLH	1	P81277
AVMIKDRWRTMKRLG	TERF2	526	Q15554
MKKLLAMILWLQLDR	TRAV39	1	A0A0B4J263