Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein kinase activity	EPHB6 KDR FLT1 EIF2AK1 ERN1 CDK15 NEK8 NRK LRRK2	3.46e-06	600	42	9	GO:0004672
GeneOntologyMolecularFunction	steroid 11-beta-monooxygenase activity	CYP11B1 CYP11B2	4.32e-06	2	42	2	GO:0004507
GeneOntologyMolecularFunction	corticosterone 18-monooxygenase activity	CYP11B1 CYP11B2	4.32e-06	2	42	2	GO:0047783
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	EPHB6 KDR FLT1 EIF2AK1 ERN1 CDK15 NEK8 NRK LRRK2	1.33e-05	709	42	9	GO:0016773
GeneOntologyMolecularFunction	kinase activity	EPHB6 KDR FLT1 EIF2AK1 ERN1 CDK15 NEK8 NRK LRRK2	2.40e-05	764	42	9	GO:0016301
GeneOntologyMolecularFunction	vascular endothelial growth factor receptor activity	KDR FLT1	9.01e-05	7	42	2	GO:0005021
GeneOntologyMolecularFunction	protein serine kinase activity	EIF2AK1 ERN1 CDK15 NEK8 NRK LRRK2	1.05e-04	363	42	6	GO:0106310
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	EPHB6 KDR FLT1 EIF2AK1 ERN1 CDK15 NEK8 NRK LRRK2	1.18e-04	938	42	9	GO:0016772
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	EIF2AK1 ERN1 CDK15 NEK8 NRK LRRK2	3.19e-04	446	42	6	GO:0004674
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP11B1 CYP11B2	3.32e-04	13	42	2	GO:0016713
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	EPHB6 KDR FLT1	3.45e-04	65	42	3	GO:0004714
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	EPHB6 KDR FLT1	7.58e-04	85	42	3	GO:0019199
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	DOCK3 HERC1 DOCK11 DOCK9	1.38e-03	231	42	4	GO:0005085
GeneOntologyMolecularFunction	steroid hydroxylase activity	CYP11B1 CYP11B2	2.32e-03	34	42	2	GO:0008395
GeneOntologyMolecularFunction	protein tyrosine kinase activity	EPHB6 KDR FLT1	3.50e-03	145	42	3	GO:0004713
GeneOntologyMolecularFunction	transcription coactivator activity	MMS19 ARID1B GTF2A1L MED7	3.70e-03	303	42	4	GO:0003713
GeneOntologyMolecularFunction	GTPase regulator activity	DOCK3 HERC1 DOCK11 DOCK9 LRRK2	4.06e-03	507	42	5	GO:0030695
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DOCK3 HERC1 DOCK11 DOCK9 LRRK2	4.06e-03	507	42	5	GO:0060589
GeneOntologyMolecularFunction	heme binding	EIF2AK1 CYP11B1 CYP11B2	4.14e-03	154	42	3	GO:0020037
GeneOntologyMolecularFunction	small GTPase binding	DOCK3 DOCK11 DOCK9 LRRK2	4.54e-03	321	42	4	GO:0031267
GeneOntologyMolecularFunction	ADP binding	ABCD1 ERN1	4.58e-03	48	42	2	GO:0043531
GeneOntologyMolecularFunction	heat shock protein binding	KDR ERN1 NFKB1	4.85e-03	163	42	3	GO:0031072
GeneOntologyMolecularFunction	tetrapyrrole binding	EIF2AK1 CYP11B1 CYP11B2	4.94e-03	164	42	3	GO:0046906
GeneOntologyMolecularFunction	signaling receptor complex adaptor activity	MMS19 LRRK2	5.77e-03	54	42	2	GO:0030159
GeneOntologyMolecularFunction	Hsp90 protein binding	KDR ERN1	5.98e-03	55	42	2	GO:0051879
GeneOntologyMolecularFunction	transcription coregulator activity	MMS19 ARID1B GTF2A1L MED7 NFKB1	6.25e-03	562	42	5	GO:0003712
GeneOntologyMolecularFunction	GTPase binding	DOCK3 DOCK11 DOCK9 LRRK2	6.78e-03	360	42	4	GO:0051020
GeneOntologyBiologicalProcess	regulation of mitochondrial depolarization	KDR ABCD1 LRRK2	1.91e-05	27	40	3	GO:0051900
GeneOntologyBiologicalProcess	regulation of blood volume by renal aldosterone	CYP11B1 CYP11B2	2.19e-05	4	40	2	GO:0002017
GeneOntologyBiologicalProcess	mitochondrial depolarization	KDR ABCD1 LRRK2	4.24e-05	35	40	3	GO:0051882
GeneOntologyBiologicalProcess	post-embryonic camera-type eye morphogenesis	KDR FLT1	5.47e-05	6	40	2	GO:0048597
GeneOntologyBiologicalProcess	protein autophosphorylation	KDR FLT1 EIF2AK1 ERN1 LRRK2	7.58e-05	228	40	5	GO:0046777
GeneOntologyBiologicalProcess	post-embryonic eye morphogenesis	KDR FLT1	7.65e-05	7	40	2	GO:0048050
GeneOntologyBiologicalProcess	macroautophagy	MTMR3 ZFYVE26 KDR EIF2AK1 ERN1 LRRK2	7.78e-05	374	40	6	GO:0016236
GeneOntologyBiologicalProcess	regulation of autophagy	MTMR3 KDR HERC1 EIF2AK1 ERN1 LRRK2	1.13e-04	400	40	6	GO:0010506
GeneOntologyBiologicalProcess	cortisol biosynthetic process	CYP11B1 CYP11B2	1.63e-04	10	40	2	GO:0034651
GeneOntologyBiologicalProcess	tertiary alcohol biosynthetic process	CYP11B1 CYP11B2	1.63e-04	10	40	2	GO:1902645
GeneOntologyBiologicalProcess	post-embryonic camera-type eye development	KDR FLT1	1.63e-04	10	40	2	GO:0031077
GeneOntologyBiologicalProcess	aldosterone biosynthetic process	CYP11B1 CYP11B2	1.99e-04	11	40	2	GO:0032342
GeneOntologyBiologicalProcess	regulation of membrane depolarization	KDR ABCD1 LRRK2	2.25e-04	61	40	3	GO:0003254
GeneOntologyBiologicalProcess	process utilizing autophagic mechanism	MTMR3 ZFYVE26 KDR HERC1 EIF2AK1 ERN1 LRRK2	2.25e-04	650	40	7	GO:0061919
GeneOntologyBiologicalProcess	autophagy	MTMR3 ZFYVE26 KDR HERC1 EIF2AK1 ERN1 LRRK2	2.25e-04	650	40	7	GO:0006914
GeneOntologyBiologicalProcess	cortisol metabolic process	CYP11B1 CYP11B2	2.39e-04	12	40	2	GO:0034650
GeneOntologyBiologicalProcess	mineralocorticoid biosynthetic process	CYP11B1 CYP11B2	2.82e-04	13	40	2	GO:0006705
GeneOntologyBiologicalProcess	primary alcohol biosynthetic process	CYP11B1 CYP11B2	3.29e-04	14	40	2	GO:0034309
GeneOntologyBiologicalProcess	aldosterone metabolic process	CYP11B1 CYP11B2	3.29e-04	14	40	2	GO:0032341
GeneOntologyBiologicalProcess	cellular response to vascular endothelial growth factor stimulus	KDR FLT1 ERN1	4.31e-04	76	40	3	GO:0035924
GeneOntologyBiologicalProcess	regulation of macroautophagy	KDR EIF2AK1 ERN1 LRRK2	4.54e-04	186	40	4	GO:0016241
GeneOntologyBiologicalProcess	transcription initiation at RNA polymerase II promoter	ARID1B GTF2A1L MED7 NFKB1	4.54e-04	186	40	4	GO:0006367
GeneOntologyBiologicalProcess	mineralocorticoid metabolic process	CYP11B1 CYP11B2	4.90e-04	17	40	2	GO:0008212
GeneOntologyBiologicalProcess	drinking behavior	CYP11B1 CYP11B2	5.50e-04	18	40	2	GO:0042756
GeneOntologyBiologicalProcess	renal system process involved in regulation of blood volume	CYP11B1 CYP11B2	5.50e-04	18	40	2	GO:0001977
GeneOntologyBiologicalProcess	glucocorticoid biosynthetic process	CYP11B1 CYP11B2	5.50e-04	18	40	2	GO:0006704
GeneOntologyBiologicalProcess	hormone biosynthetic process	CYP11B1 CYP11B2 NFKB1	5.58e-04	83	40	3	GO:0042446
GeneOntologyBiologicalProcess	multicellular organismal-level chemical homeostasis	KDR EIF2AK1 CYP11B2	7.06e-04	90	40	3	GO:0140962
GeneOntologyBiologicalProcess	tertiary alcohol metabolic process	CYP11B1 CYP11B2	8.27e-04	22	40	2	GO:1902644
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	CYP11B1 CYP11B2	9.04e-04	23	40	2	GO:0001991
GeneOntologyBiologicalProcess	regulation of mitochondrial membrane potential	KDR ABCD1 LRRK2	9.59e-04	100	40	3	GO:0051881
GeneOntologyBiologicalProcess	response to starvation	MTMR3 EIF2AK1 SZT2 LRRK2	9.89e-04	229	40	4	GO:0042594
GeneOntologyBiologicalProcess	DNA-templated transcription initiation	ARID1B GTF2A1L MED7 NFKB1	1.02e-03	231	40	4	GO:0006352
GeneOntologyBiologicalProcess	C21-steroid hormone biosynthetic process	CYP11B1 CYP11B2	1.16e-03	26	40	2	GO:0006700
GeneOntologyBiologicalProcess	glucocorticoid metabolic process	CYP11B1 CYP11B2	1.25e-03	27	40	2	GO:0008211
GeneOntologyBiologicalProcess	positive regulation of systemic arterial blood pressure	CYP11B1 CYP11B2	1.34e-03	28	40	2	GO:0003084
GeneOntologyBiologicalProcess	aldehyde biosynthetic process	CYP11B1 CYP11B2	1.65e-03	31	40	2	GO:0046184
GeneOntologyBiologicalProcess	renal system process involved in regulation of systemic arterial blood pressure	CYP11B1 CYP11B2	1.65e-03	31	40	2	GO:0003071
GeneOntologyBiologicalProcess	membrane depolarization	KDR ABCD1 LRRK2	1.66e-03	121	40	3	GO:0051899
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure	KDR CYP11B1 CYP11B2	1.78e-03	124	40	3	GO:0003073
GeneOntologyBiologicalProcess	corpus callosum development	HERC1 SZT2	1.86e-03	33	40	2	GO:0022038
GeneOntologyBiologicalProcess	positive regulation of MAP kinase activity	FLT1 ERN1 LRRK2	1.99e-03	129	40	3	GO:0043406
GeneOntologyBiologicalProcess	autophagosome organization	MTMR3 ZFYVE26 LRRK2	1.99e-03	129	40	3	GO:1905037
HumanPheno	Secretory adrenocortical adenoma	CYP11B1 CYP11B2	3.14e-05	3	17	2	HP:0011746
MousePheno	abnormal urine progesterone level	CYP11B1 CYP11B2	5.74e-06	2	34	2	MP:0011545
MousePheno	abnormal urine deoxycorticosterone level	CYP11B1 CYP11B2	5.74e-06	2	34	2	MP:0011552
MousePheno	decreased urine corticosterone level	CYP11B1 CYP11B2	5.74e-06	2	34	2	MP:0011550
MousePheno	increased urine deoxycorticosterone level	CYP11B1 CYP11B2	5.74e-06	2	34	2	MP:0011553
MousePheno	increased urine progesterone level	CYP11B1 CYP11B2	5.74e-06	2	34	2	MP:0011546
MousePheno	abnormal kidney weight	ARID1B DOCK11 CYP11B1 CYP11B2 NEK8 LRRK2	9.59e-06	208	34	6	MP:0002707
MousePheno	abnormal adrenal gland zona fasciculata morphology	ABCD1 CYP11B1 CYP11B2	1.24e-05	19	34	3	MP:0008294
MousePheno	increased kidney weight	DOCK11 CYP11B1 CYP11B2 NEK8 LRRK2	2.45e-05	145	34	5	MP:0003917
MousePheno	abnormal adrenal gland zona glomerulosa morphology	CYP11B1 CYP11B2	3.43e-05	4	34	2	MP:0008293
MousePheno	decreased urine aldosterone level	CYP11B1 CYP11B2	3.43e-05	4	34	2	MP:0011541
MousePheno	abnormal urine aldosterone level	CYP11B1 CYP11B2	3.43e-05	4	34	2	MP:0011539
MousePheno	abnormal urine corticosterone level	CYP11B1 CYP11B2	3.43e-05	4	34	2	MP:0011548
MousePheno	decreased urine hormone level	CYP11B1 CYP11B2	3.43e-05	4	34	2	MP:0014459
MousePheno	increased adrenal gland zona fasciculata size	CYP11B1 CYP11B2	5.72e-05	5	34	2	MP:0014286
MousePheno	uterus adenomyosis	CYP11B1 CYP11B2	8.56e-05	6	34	2	MP:0009221
MousePheno	increased urine hormone level	CYP11B1 CYP11B2	8.56e-05	6	34	2	MP:0014458
MousePheno	adrenal gland hyperplasia	CYP11B1 CYP11B2	8.56e-05	6	34	2	MP:0009078
MousePheno	abnormal response/metabolism to endogenous compounds	ERN1 CYP11B1 CYP11B2 LRRK2	1.13e-04	104	34	4	MP:0003638
MousePheno	abnormal urine hormone level	CYP11B1 CYP11B2	1.20e-04	7	34	2	MP:0011538
MousePheno	pituitary gland hyperplasia	CYP11B1 CYP11B2	1.20e-04	7	34	2	MP:0000635
MousePheno	abnormal adrenal cortex morphology	ABCD1 CYP11B1 CYP11B2	1.41e-04	42	34	3	MP:0008288
MousePheno	increased circulating angiotensin II level	CYP11B1 CYP11B2	1.59e-04	8	34	2	MP:0031232
MousePheno	increased angiotensin II level	CYP11B1 CYP11B2	1.59e-04	8	34	2	MP:0031229
MousePheno	abnormal endometrium morphology	CENPB CYP11B1 CYP11B2	2.24e-04	49	34	3	MP:0004896
MousePheno	decreased circulating renin level	CYP11B1 CYP11B2	2.55e-04	10	34	2	MP:0003353
MousePheno	abnormal adrenocortical cell morphology	CYP11B1 CYP11B2	2.55e-04	10	34	2	MP:0008291
MousePheno	decreased effector memory CD4-positive, alpha-beta T cell number	NEK8 NFKB1	2.55e-04	10	34	2	MP:0010845
MousePheno	abnormal adrenal gland zona fasciculata size	CYP11B1 CYP11B2	3.12e-04	11	34	2	MP:0014284
MousePheno	uterus cyst	CYP11B1 CYP11B2	3.12e-04	11	34	2	MP:0009082
MousePheno	abnormal circulating angiotensin II level	CYP11B1 CYP11B2	3.73e-04	12	34	2	MP:0031230
MousePheno	abnormal angiotensin II level	CYP11B1 CYP11B2	3.73e-04	12	34	2	MP:0031227
MousePheno	hypokalemia	CYP11B1 CYP11B2	3.73e-04	12	34	2	MP:0004119
MousePheno	enlarged pituitary gland	CYP11B1 CYP11B2	3.73e-04	12	34	2	MP:0000636
MousePheno	increased renin activity	CYP11B1 CYP11B2	5.13e-04	14	34	2	MP:0005582
MousePheno	decreased circulating mineralocorticoid level	CYP11B1 CYP11B2	5.13e-04	14	34	2	MP:0003374
MousePheno	increased urine osmolality	CYP11B1 CYP11B2	5.13e-04	14	34	2	MP:0008055
MousePheno	increased circulating adrenocorticotropin level	CYP11B1 CYP11B2	5.13e-04	14	34	2	MP:0001748
MousePheno	decreased circulating aldosterone level	CYP11B1 CYP11B2	5.13e-04	14	34	2	MP:0002667
MousePheno	endometrium hyperplasia	CYP11B1 CYP11B2	5.13e-04	14	34	2	MP:0009092
MousePheno	increased systemic arterial blood pressure	CYP11B1 CYP11B2 NEK8 LRRK2	5.59e-04	158	34	4	MP:0002842
MousePheno	increased systemic arterial systolic blood pressure	CYP11B1 CYP11B2 NEK8	6.99e-04	72	34	3	MP:0006144
MousePheno	abnormal mineral homeostasis	MTMR3 ZFYVE26 HERC1 EIF2AK1 DSEL C2CD2 CYP11B1 CYP11B2 NFKB1	8.27e-04	1076	34	9	MP:0005636
MousePheno	decreased CD4-positive, alpha-beta memory T cell number	NEK8 NFKB1	8.57e-04	18	34	2	MP:0010836
MousePheno	abnormal renin activity	CYP11B1 CYP11B2	1.06e-03	20	34	2	MP:0005581
MousePheno	increased adrenocorticotropin level	CYP11B1 CYP11B2	1.29e-03	22	34	2	MP:0005129
MousePheno	axon degeneration	DOCK3 ZFYVE26 ABCD1	1.38e-03	91	34	3	MP:0005405
MousePheno	increased circulating renin level	CYP11B1 CYP11B2	1.41e-03	23	34	2	MP:0003352
MousePheno	pregnancy-related premature death	CENPB NRK	1.41e-03	23	34	2	MP:0008028
MousePheno	oliguria	CYP11B1 CYP11B2	1.53e-03	24	34	2	MP:0003620
MousePheno	enlarged kidney	DOCK11 CYP11B1 CYP11B2 NEK8 LRRK2	1.54e-03	354	34	5	MP:0003068
MousePheno	abnormal hippocampal mossy fiber morphology	LRRK2 STON2	1.94e-03	27	34	2	MP:0002761
MousePheno	hypotension	CYP11B1 CYP11B2	2.09e-03	28	34	2	MP:0001596
MousePheno	abnormal circulating renin level	CYP11B1 CYP11B2	2.24e-03	29	34	2	MP:0003349
MousePheno	decreased circulating mineral level	ZFYVE26 C2CD2 CYP11B1 CYP11B2 NFKB1	2.38e-03	391	34	5	MP:0014548
MousePheno	abnormal visceral yolk sac blood island morphology	KDR FLT1	2.72e-03	32	34	2	MP:0011204
Domain	Prot_kinase_dom	EPHB6 KDR FLT1 EIF2AK1 ERN1 CDK15 NEK8 NRK LRRK2	1.11e-06	489	42	9	IPR000719
Domain	PROTEIN_KINASE_DOM	EPHB6 KDR FLT1 EIF2AK1 ERN1 CDK15 NEK8 NRK LRRK2	1.19e-06	493	42	9	PS50011
Domain	DOCK_C	DOCK3 DOCK11 DOCK9	1.72e-06	11	42	3	IPR010703
Domain	DHR-1_domain	DOCK3 DOCK11 DOCK9	1.72e-06	11	42	3	IPR027007
Domain	DHR_2	DOCK3 DOCK11 DOCK9	1.72e-06	11	42	3	PS51651
Domain	DHR_1	DOCK3 DOCK11 DOCK9	1.72e-06	11	42	3	PS51650
Domain	DOCK-C2	DOCK3 DOCK11 DOCK9	1.72e-06	11	42	3	PF14429
Domain	DHR-2	DOCK3 DOCK11 DOCK9	1.72e-06	11	42	3	IPR027357
Domain	DHR-2	DOCK3 DOCK11 DOCK9	1.72e-06	11	42	3	PF06920
Domain	DOCK	DOCK3 DOCK11 DOCK9	1.72e-06	11	42	3	IPR026791
Domain	Kinase-like_dom	EPHB6 KDR FLT1 EIF2AK1 ERN1 CDK15 NEK8 NRK LRRK2	2.59e-06	542	42	9	IPR011009
Domain	Cyt_P450_mitochondrial	CYP11B1 CYP11B2	4.94e-06	2	42	2	IPR002399
Domain	PROTEIN_KINASE_ATP	KDR FLT1 EIF2AK1 ERN1 CDK15 NEK8 NRK LRRK2	7.09e-06	459	42	8	PS00107
Domain	ARM-type_fold	DOCK3 MMS19 HEATR6 DOCK11 MROH2A DOCK9 LRRK2	9.53e-06	339	42	7	IPR016024
Domain	Protein_kinase_ATP_BS	KDR FLT1 EIF2AK1 CDK15 NEK8 NRK LRRK2	1.96e-05	379	42	7	IPR017441
Domain	DUF3398	DOCK11 DOCK9	7.36e-05	6	42	2	PF11878
Domain	DOCK_C/D_N	DOCK11 DOCK9	7.36e-05	6	42	2	IPR021816
Domain	RECEPTOR_TYR_KIN_III	KDR FLT1	1.37e-04	8	42	2	PS00240
Domain	Tyr_kinase_rcpt_3_CS	KDR FLT1	1.37e-04	8	42	2	IPR001824
Domain	Ser/Thr_kinase_AS	EIF2AK1 ERN1 CDK15 NEK8 NRK LRRK2	1.37e-04	357	42	6	IPR008271
Domain	S_TKc	EIF2AK1 ERN1 CDK15 NEK8 NRK LRRK2	1.41e-04	359	42	6	SM00220
Domain	PROTEIN_KINASE_ST	EIF2AK1 ERN1 CDK15 NEK8 NRK LRRK2	1.48e-04	362	42	6	PS00108
Domain	Pkinase	EIF2AK1 ERN1 CDK15 NEK8 NRK LRRK2	1.95e-04	381	42	6	PF00069
Domain	Ser-Thr/Tyr_kinase_cat_dom	EPHB6 KDR FLT1 NEK8	2.57e-04	138	42	4	IPR001245
Domain	ARM-like	MMS19 ARID1B HEATR6 MROH2A LRRK2	3.34e-04	270	42	5	IPR011989
Domain	HEAT_REPEAT	MMS19 HEATR6 MROH2A	5.21e-04	70	42	3	PS50077
Domain	RCC1	HERC1 NEK8	9.14e-04	20	42	2	PF00415
Domain	RCC1_3	HERC1 NEK8	1.01e-03	21	42	2	PS50012
Domain	RCC1_1	HERC1 NEK8	1.01e-03	21	42	2	PS00625
Domain	RCC1_2	HERC1 NEK8	1.01e-03	21	42	2	PS00626
Domain	Reg_chr_condens	HERC1 NEK8	1.11e-03	22	42	2	IPR000408
Domain	-	HERC1 NEK8	1.11e-03	22	42	2	2.130.10.30
Domain	RCC1/BLIP-II	HERC1 NEK8	1.21e-03	23	42	2	IPR009091
Domain	-	MMS19 ARID1B HEATR6 LRRK2	1.53e-03	222	42	4	1.25.10.10
Domain	FYVE	MTMR3 ZFYVE26	1.93e-03	29	42	2	PF01363
Domain	FYVE	MTMR3 ZFYVE26	1.93e-03	29	42	2	SM00064
Domain	Znf_FYVE-rel	MTMR3 ZFYVE26	2.65e-03	34	42	2	IPR017455
Domain	Pkinase_Tyr	EPHB6 KDR FLT1	3.04e-03	129	42	3	PF07714
Domain	Znf_FYVE	MTMR3 ZFYVE26	3.30e-03	38	42	2	IPR000306
Domain	ZF_FYVE	MTMR3 ZFYVE26	3.65e-03	40	42	2	PS50178
Domain	p53-like_TF_DNA-bd	NRK NFKB1	6.33e-03	53	42	2	IPR008967
Domain	Cyt_P450_CS	CYP11B1 CYP11B2	6.33e-03	53	42	2	IPR017972
Domain	CYTOCHROME_P450	CYP11B1 CYP11B2	7.29e-03	57	42	2	PS00086
Domain	-	CYP11B1 CYP11B2	7.54e-03	58	42	2	1.10.630.10
Pathway	KEGG_MEDICUS_REFERENCE_STEROID_HORMONE_BIOSYNTHESIS_PROGESTERONE_TO_CORTISOL_CORTISONE	CYP11B1 CYP11B2	4.97e-05	5	32	2	M47522
Pathway	REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS	KDR FLT1	1.39e-04	8	32	2	M710
Pathway	REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS	KDR FLT1	1.39e-04	8	32	2	MM14753
Pathway	WP_ID_SIGNALING_PATHWAY	KDR FLT1 NFKB1	1.94e-04	50	32	3	MM15817
Pathway	PID_VEGF_VEGFR_PATHWAY	KDR FLT1	2.22e-04	10	32	2	M137
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	2.22e-04	10	32	2	M27076
Pathway	WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER	KDR FLT1 NFKB1	2.44e-04	54	32	3	M42568
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	2.71e-04	11	32	2	MM14750
Pathway	REACTOME_MINERALOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	3.25e-04	12	32	2	MM14749
Pathway	WP_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	4.47e-04	14	32	2	M46449
Pathway	WP_MINERALOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	4.47e-04	14	32	2	M46453
Pathway	WP_CLASSICAL_PATHWAY_OF_STEROIDOGENESIS_WITH_GLUCOCORTICOID_AND_MINERALOCORTICOID_METABOLISM	CYP11B1 CYP11B2	5.87e-04	16	32	2	M39815
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MTMR3 DOCK3 PDCD11 ZFYVE26 ABCD1 HERC1 SZT2 PCNX4 C2CD2 NEK8 DOCK9 KIAA2013	6.16e-09	1105	43	12	35748872
Pubmed	Maternal corticosterone exposure in the mouse has sex-specific effects on placental growth and mRNA expression.	KDR CYP11B1 CYP11B2	3.84e-07	12	43	3	22919064
Pubmed	Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.	DOCK3 DOCK11 DOCK9	6.35e-07	14	43	3	12432077
Pubmed	Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.	CYP11B1 CYP11B2	1.49e-06	2	43	2	17651452
Pubmed	Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium.	KDR FLT1	1.49e-06	2	43	2	8356051
Pubmed	Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.	CYP11B1 CYP11B2	1.49e-06	2	43	2	23150505
Pubmed	Hypoxia-induced reduction of sVEGFR-2 levels in human colonic microvascular endothelial cells in vitro: Comparative study with HUVEC.	KDR FLT1	1.49e-06	2	43	2	19082506
Pubmed	VEGFR1 and VEGFR2 immunohistochemical expression in oral squamous cell carcinoma: a morphometric study.	KDR FLT1	1.49e-06	2	43	2	22203933
Pubmed	Vascular endothelial growth factor and its receptors in normal human testicular tissue.	KDR FLT1	1.49e-06	2	43	2	9256359
Pubmed	Expression of CYP11B1 and CYP11B2 in adrenal adenoma correlates with clinical characteristics of primary aldosteronism.	CYP11B1 CYP11B2	1.49e-06	2	43	2	34743356
Pubmed	Expression of vascular endothelial growth factor receptors in the endometrium of septate uterus.	KDR FLT1	1.49e-06	2	43	2	19200976
Pubmed	Production of VEGF receptor 1 and 2 mRNA and protein during endochondral bone repair is differential and healing phase specific.	KDR FLT1	1.49e-06	2	43	2	20947709
Pubmed	GRAde: a long-read sequencing approach to efficiently identifying the CYP11B1/CYP11B2 chimeric form in patients with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	1.49e-06	2	43	2	35012455
Pubmed	Role of genetic variation in regulation of aldosterone biosynthesis.	CYP11B1 CYP11B2	1.49e-06	2	43	2	21164264
Pubmed	Absence of mutations in the activation loop and juxtamembrane domains of VEGFR-1 and VEGFR-2 gene in chronic myelomonocytic leukemia (CMML).	KDR FLT1	1.49e-06	2	43	2	22153185
Pubmed	Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism.	CYP11B1 CYP11B2	1.49e-06	2	43	2	20339375
Pubmed	Angiogenesis in systemic sclerosis: impaired expression of vascular endothelial growth factor receptor 1 in endothelial progenitor-derived cells under hypoxic conditions.	KDR FLT1	1.49e-06	2	43	2	18975312
Pubmed	Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice.	KDR FLT1	1.49e-06	2	43	2	15852018
Pubmed	VEGFR1 and VEGFR2 in lip carcinogenesis and its association with microvessel density.	KDR FLT1	1.49e-06	2	43	2	25895461
Pubmed	Soluble forms of VEGF receptor-1 and -2 promote vascular maturation via mural cell recruitment.	KDR FLT1	1.49e-06	2	43	2	20484670
Pubmed	VEGFR1 and VEGFR2 in Alzheimer's Disease.	KDR FLT1	1.49e-06	2	43	2	29226875
Pubmed	Genetic analyses of the chimeric CYP11B1/CYP11B2 gene in a Korean family with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	1.49e-06	2	43	2	20808686
Pubmed	The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching.	KDR FLT1	1.49e-06	2	43	2	18504303
Pubmed	The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity.	CYP11B1 CYP11B2	1.49e-06	2	43	2	8645611
Pubmed	Evidence in support of a role for anti-angiogenic factors in preterm prelabor rupture of membranes.	KDR FLT1	1.49e-06	2	43	2	20158393
Pubmed	Blockade of VEGFR1 and 2 suppresses pathological angiogenesis and vascular leakage in the eye.	KDR FLT1	1.49e-06	2	43	2	21731737
Pubmed	Expression of VEGF receptors on endothelial cells in mouse skeletal muscle.	KDR FLT1	1.49e-06	2	43	2	22984559
Pubmed	Expression of vascular endothelial growth factor receptors is closely related to the histological grade of hepatocellular carcinoma.	KDR FLT1	1.49e-06	2	43	2	16786116
Pubmed	Differential expression of the two VEGF receptors flt and KDR in placenta and vascular endothelial cells.	KDR FLT1	1.49e-06	2	43	2	8126087
Pubmed	Quantitative assessment and clinical relevance of VEGFRs-positive tumor cells in refractory brain tumors.	KDR FLT1	1.49e-06	2	43	2	32088190
Pubmed	Expression and localization of cytochrome P450(11beta,aldo) mRNA in the frog brain.	CYP11B1 CYP11B2	1.49e-06	2	43	2	12231255
Pubmed	Expression of vascular endothelial growth factor receptors during male germ cell differentiation in the mouse.	KDR FLT1	1.49e-06	2	43	2	12773425
Pubmed	A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type I.	CYP11B1 CYP11B2	1.49e-06	2	43	2	20634641
Pubmed	VEGF receptor blockade markedly reduces retinal microglia/macrophage infiltration into laser-induced CNV.	KDR FLT1	1.49e-06	2	43	2	23977149
Pubmed	A cyclic peptide reproducing the α1 helix of VEGF-B binds to VEGFR-1 and VEGFR-2 and inhibits angiogenesis and tumor growth.	KDR FLT1	1.49e-06	2	43	2	30700502
Pubmed	Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation.	KDR FLT1	1.49e-06	2	43	2	15611243
Pubmed	Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.	CYP11B1 CYP11B2	1.49e-06	2	43	2	1303253
Pubmed	Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets.	CYP11B1 CYP11B2	1.49e-06	2	43	2	21519965
Pubmed	Diagnosis of glucocorticoid-remediable aldosteronism in hypertensive children.	CYP11B1 CYP11B2	1.49e-06	2	43	2	21625068
Pubmed	Genetic screening for glucocorticoid-remediable aldosteronism (GRA): experience of three clinical centres in Poland.	CYP11B1 CYP11B2	1.49e-06	2	43	2	16110193
Pubmed	Differential sex-specific effects of oxygen toxicity in human umbilical vein endothelial cells.	KDR NFKB1	1.49e-06	2	43	2	28315681
Pubmed	Chimeric CYP11B2/CYP11B1 causing 11β-hydroxylase deficiency in Chinese patients with congenital adrenal hyperplasia.	CYP11B1 CYP11B2	1.49e-06	2	43	2	26066897
Pubmed	Bone formation during distraction osteogenesis is dependent on both VEGFR1 and VEGFR2 signaling.	KDR FLT1	1.49e-06	2	43	2	18433297
Pubmed	Inhibition of prostate cancer osteoblastic progression with VEGF121/rGel, a single agent targeting osteoblasts, osteoclasts, and tumor neovasculature.	KDR FLT1	1.49e-06	2	43	2	21343372
Pubmed	Selected angiogenic cytokines in systemic lupus erythematosus patients.	KDR FLT1	1.49e-06	2	43	2	19811263
Pubmed	Flt1 and Flk1 mediate regulation of intraocular pressure and their double heterozygosity causes the buphthalmia in mice.	KDR FLT1	1.49e-06	2	43	2	22426483
Pubmed	The vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formation.	KDR FLT1	1.49e-06	2	43	2	15111299
Pubmed	VEGFR1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitment.	KDR FLT1	1.49e-06	2	43	2	18174461
Pubmed	Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.	CYP11B1 CYP11B2	1.49e-06	2	43	2	1741400
Pubmed	Increased expression of KDR/Flk-1 (VEGFR-2) in murine model of ischemia-induced retinal neovascularization.	KDR FLT1	1.49e-06	2	43	2	9828156
Pubmed	The effects of VEGF-R1 and VEGF-R2 ligands on angiogenic responses and left ventricular function in mice.	KDR FLT1	1.49e-06	2	43	2	19955220
Pubmed	Bovine papular stomatitis virus encodes a functionally distinct VEGF that binds both VEGFR-1 and VEGFR-2.	KDR FLT1	1.49e-06	2	43	2	17325350
Pubmed	Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice.	CYP11B1 CYP11B2	1.49e-06	2	43	2	32540969
Pubmed	Phase III Trial of Adjuvant Sunitinib in Patients with High-Risk Renal Cell Carcinoma: Exploratory Pharmacogenomic Analysis.	KDR FLT1	1.49e-06	2	43	2	30401688
Pubmed	Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells.	KDR FLT1	1.49e-06	2	43	2	19265665
Pubmed	Involvement of VEGFR-2 (kdr/flk-1) but not VEGFR-1 (flt-1) in VEGF-A and VEGF-C-induced tube formation by human microvascular endothelial cells in fibrin matrices in vitro.	KDR FLT1	1.49e-06	2	43	2	11824379
Pubmed	Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice.	CYP11B1 CYP11B2	1.49e-06	2	43	2	26047574
Pubmed	VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia.	KDR FLT1	1.49e-06	2	43	2	14996703
Pubmed	Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF.	KDR FLT1	1.49e-06	2	43	2	17376891
Pubmed	Aldosterone synthase knockout mouse as a model for sodium-induced endothelial sodium channel up-regulation in vascular endothelium.	CYP11B1 CYP11B2	1.49e-06	2	43	2	26324851
Pubmed	Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules.	CYP11B1 CYP11B2	1.49e-06	2	43	2	18651133
Pubmed	Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains.	CYP11B1 CYP11B2	1.49e-06	2	43	2	7669222
Pubmed	Herbal compound farnesiferol C exerts antiangiogenic and antitumor activity and targets multiple aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) signaling cascades.	KDR FLT1	1.49e-06	2	43	2	20103598
Pubmed	A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation pattern.	CYP11B1 CYP11B2	1.49e-06	2	43	2	22083159
Pubmed	Quantitative real-time reverse transcription PCR study of the expression of vascular endothelial growth factor (VEGF) splice variants and VEGF receptors (VEGFR-1 and VEGFR-2) in non small cell lung cancer.	KDR FLT1	1.49e-06	2	43	2	17599955
Pubmed	Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron.	CYP11B1 CYP11B2	1.49e-06	2	43	2	22933298
Pubmed	Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival.	KDR FLT1	1.49e-06	2	43	2	16793887
Pubmed	The soluble VEGF receptor 1 and 2 expression in cerebral spinal fluid as an indicator for leukemia central nervous system metastasis.	KDR FLT1	1.49e-06	2	43	2	23400753
Pubmed	Vascular endothelial growth factor and its soluble receptors VEGFR-1 and VEGFR-2 in the serum of patients with systemic lupus erythematosus.	KDR FLT1	1.49e-06	2	43	2	14760936
Pubmed	Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	1.49e-06	2	43	2	2783417
Pubmed	DC electric stimulation upregulates angiogenic factors in endothelial cells through activation of VEGF receptors.	KDR FLT1	1.49e-06	2	43	2	21524919
Pubmed	Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.	CYP11B1 CYP11B2	1.49e-06	2	43	2	2256920
Pubmed	Editorial: polymorphisms in CYP11B genes and 11-hydroxylase activity.	CYP11B1 CYP11B2	1.49e-06	2	43	2	15699546
Pubmed	VEGFR1 and VEGFR2 involvement in extracellular galectin-1- and galectin-3-induced angiogenesis.	KDR FLT1	1.49e-06	2	43	2	23799140
Pubmed	Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway.	CYP11B1 CYP11B2	1.49e-06	2	43	2	18162527
Pubmed	Chronic activation of adrenal Gq signaling induces Cyp11b2 expression in the zona fasciculata and hyperaldosteronism.	CYP11B1 CYP11B2	1.49e-06	2	43	2	38341019
Pubmed	Endothelial progenitor cells induce transplant arteriosclerosis via VEGFR-1/2 activity.	KDR FLT1	1.49e-06	2	43	2	25437886
Pubmed	Association of DNA polymorphisms within the CYP11B2/CYP11B1 locus and postoperative hypertension risk in the patients with aldosterone-producing adenomas.	CYP11B1 CYP11B2	1.49e-06	2	43	2	20708777
Pubmed	VEGFR2-mediated vascular dilation as a mechanism of VEGF-induced anemia and bone marrow cell mobilization.	KDR FLT1	1.49e-06	2	43	2	25310988
Pubmed	Molecular genetic studies on the biosynthesis of aldosterone in humans.	CYP11B1 CYP11B2	1.49e-06	2	43	2	22217843
Pubmed	Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia.	KDR FLT1	1.49e-06	2	43	2	9295307
Pubmed	Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation.	CYP11B1 CYP11B2	1.49e-06	2	43	2	16396990
Pubmed	Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.	CYP11B1 CYP11B2	1.49e-06	2	43	2	24837548
Pubmed	Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity.	CYP11B1 CYP11B2	1.49e-06	2	43	2	30046010
Pubmed	Trophoblast expression of fms-like tyrosine kinase 1 is not required for the establishment of the maternal-fetal interface in the mouse placenta.	KDR FLT1	1.49e-06	2	43	2	14668430
Pubmed	Inhibition of VEGF receptors significantly impairs mammary cancer growth in C3(1)/Tag transgenic mice through antiangiogenic and non-antiangiogenic mechanisms.	KDR FLT1	1.49e-06	2	43	2	15592523
Pubmed	Endothelial cell-by-cell profiling reveals the temporal dynamics of VEGFR1 and VEGFR2 membrane localization after murine hindlimb ischemia.	KDR FLT1	1.49e-06	2	43	2	23376830
Pubmed	Familial and phenotypic associations of the aldosterone Renin ratio.	CYP11B1 CYP11B2	1.49e-06	2	43	2	19820005
Pubmed	[123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes.	CYP11B1 CYP11B2	1.49e-06	2	43	2	18397978
Pubmed	Identification of functional VEGF receptors on human platelets.	KDR FLT1	1.49e-06	2	43	2	11852061
Pubmed	Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.	CYP11B1 CYP11B2	1.49e-06	2	43	2	1518866
Pubmed	Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies.	KDR FLT1	1.49e-06	2	43	2	9973224
Pubmed	Expression of vascular endothelial growth factor receptor-1/-2 and nitric oxide in unruptured intracranial aneurysms.	KDR FLT1	1.49e-06	2	43	2	20635108
Pubmed	Hypoxia differentially regulates VEGFR1 and VEGFR2 levels and alters intracellular signaling and cell migration in endothelial cells.	KDR FLT1	1.49e-06	2	43	2	21168388
Pubmed	Distinct expression patterns of Flk1 and Flt1 in the coronary vascular system during development and after myocardial infarction.	KDR FLT1	1.49e-06	2	43	2	29158084
Pubmed	Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.	CYP11B1 CYP11B2	1.49e-06	2	43	2	22622494
Pubmed	Distinct roles of vascular endothelial growth factor receptor-1- and receptor-2-mediated signaling in T cell priming and Th17 polarization to lipopolysaccharide-containing allergens in the lung.	KDR FLT1	1.49e-06	2	43	2	20921519
Pubmed	Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production.	CYP11B1 CYP11B2	1.49e-06	2	43	2	15062555
Pubmed	Procollagen I-expressing renin cell precursors.	CYP11B1 CYP11B2	1.49e-06	2	43	2	23761669
Pubmed	Vascular endothelial growth factor-induced genes in human umbilical vein endothelial cells: relative roles of KDR and Flt-1 receptors.	KDR FLT1	1.49e-06	2	43	2	12426207
Interaction	TOP3B interactions	MTMR3 DOCK3 PDCD11 ZFYVE26 MMS19 ABCD1 HERC1 SZT2 PCNX4 C2CD2 NEK8 DOCK9 KIAA2013	4.00e-06	1470	41	13	int:TOP3B
GeneFamily	Cytochrome P450 family 11	CYP11B1 CYP11B2	5.96e-06	3	26	2	1007
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	MTMR3 ZFYVE26	9.01e-04	31	26	2	81
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	KDR FLT1	1.50e-03	40	26	2	321
GeneFamily	Immunoglobulin like domain containing	KDR FLT1 CCDC141	2.60e-03	193	26	3	594
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	KDR FLT1	2.23e-02	161	26	2	593
Coexpression	GSE45365_WT_VS_IFNAR_KO_BCELL_DN	BTBD16 MAGEA11 PDPR DSEL CCDC141	1.54e-05	192	43	5	M9987
Coexpression	LIU_OVARIAN_CANCER_TUMORS_AND_XENOGRAFTS_KINASES_DN	KDR FLT1 LRRK2	1.97e-05	32	43	3	MM17
Coexpression	LIU_OVARIAN_CANCER_TUMORS_AND_XENOGRAFTS_KINASES_DN	KDR FLT1 LRRK2	2.38e-05	34	43	3	M45005
ToppCell	Control-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	ERN1 CCDC141 DOCK9 NFKB1 LRRK2	1.19e-06	194	43	5	a01de094f7bfd099bcbb2f94224690a2efb887b4
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MTMR3 KDR FLT1 C2CD2	1.54e-05	156	43	4	1928c86deb3bcd01db4ae76919a351066aadb39a
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPHB6 MMS19 CENPB PROX2	1.75e-05	161	43	4	2849fbc9611af208241b33da3cd18290aafe426b
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KDR GTF2A1L EFCAB6 STON2	1.97e-05	166	43	4	5e3b998d740b24f790fad37350d704ca0ea10b77
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l22\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KDR GTF2A1L EFCAB6 STON2	1.97e-05	166	43	4	bcdaab49bde5beba750b76fdcc3781a3c12c4fff
ToppCell	368C-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	DSEL ERN1 NEK8 DOP1B	2.21e-05	171	43	4	f3bf5805823d5733b58742172e7668725ce82931
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MTMR3 KDR DOCK9 STON2	2.42e-05	175	43	4	43be63976da5ad0764d24d90919a77ce46068f52
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BTBD16 DOCK11 NRK LRRK2	2.83e-05	182	43	4	eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCell	3'-Adult-Appendix-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KDR FLT1 DOCK9 LRRK2	3.14e-05	187	43	4	ec98d5e480b08854dfd0ba6b1dc6610455f90640
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHB6 SZT2 DOCK9 DOP1B	3.14e-05	187	43	4	3699d5e71d779da922920aa3160895db187bf81b
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHB6 SZT2 DOCK9 DOP1B	3.14e-05	187	43	4	033ba52c0c2f9978784947098fa697368ae44834
ToppCell	3'-Adult-Appendix-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KDR FLT1 DOCK9 LRRK2	3.14e-05	187	43	4	37d8ee5c8bd6324749e5a2adef1d0482c75da80c
ToppCell	wk_15-18-Endothelial-Lymph_endothelial-Intermediate_lymphatic_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	KDR CCDC141 DOCK9 STON2	3.41e-05	191	43	4	d25ac3206fe205a100cfee26431ff32c14c1938f
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D122\|Adult / Lineage, Cell type, age group and donor	BTBD16 CCDC141 DOCK9 LRRK2	3.48e-05	192	43	4	06013a07e3a873b1d1c0451643c528593ac32a9c
ToppCell	PCW_13-14-Endothelial-Endothelial_immature-endo_immature4_(5)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	KDR FLT1 CCDC141 DOCK9	3.55e-05	193	43	4	01c71aa48875b5ad6c50cc810a72862e72f26ad0
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BTBD16 CCDC141 DOCK9 LRRK2	3.63e-05	194	43	4	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC3-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ARID1B ERN1 NEK8 PROX2	3.70e-05	195	43	4	d8fa96c8f14bd088c3f8bd14f894a2c5b7ad46a7
ToppCell	PCW_13-14-Endothelial-Endothelial_immature-endo_immature2_(1)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	KDR FLT1 CCDC141 DOCK9	3.77e-05	196	43	4	b0288e28a6e6222a9e310eb6fe228c04b618db13
ToppCell	background-Endothelial_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	KDR FLT1 HERC1 DOCK9	3.77e-05	196	43	4	e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature2_(1)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	KDR FLT1 CCDC141 DOCK9	3.77e-05	196	43	4	0e8d649b50be2d707510b897bb97767b5847dff9
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature_venous_(4)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	KDR FLT1 CCDC141 DOCK9	3.77e-05	196	43	4	81278e696d823744267d6315c4d42799c4ea0b2c
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature3_(11)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	KDR FLT1 CCDC141 DOCK9	3.85e-05	197	43	4	a7922f65a8af4a773e4ce80114e4d895a594fa2f
ToppCell	PCW_13-14-Endothelial-Endothelial_immature-endo_immature_venous_(4)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	KDR FLT1 CCDC141 DOCK9	3.85e-05	197	43	4	88859b7b24b36afab4a684fd7abf0e0f8e5b525c
ToppCell	PCW_13-14-Endothelial-Endothelial_cycling-endo_proliferating3_(3)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	KDR FLT1 CCDC141 DOCK9	3.85e-05	197	43	4	aedc1e3ed6b558bf2f7649919f43049f8348ab85
ToppCell	PCW_10-12-Endothelial-Endothelial_cycling-endo_proliferating3_(3)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	KDR FLT1 CCDC141 DOCK9	3.93e-05	198	43	4	5fe186d46c47ea1ca450cf67e8eb01c2c3f7f83c
ToppCell	P28-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	EFCAB6 CDK15 NEK8	4.39e-04	154	43	3	44d4d99b08216c0901e3bc32743fa0a8b85b5149
ToppCell	COPD-Epithelial-Aberrant_Basaloid\|Epithelial / Disease state, Lineage and Cell class	DOCK3 KDR NRK	4.73e-04	158	43	3	8f66979e92f886d86cecbd26aaa0c5915c049734
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	ABCD1 ERN1 NEK8	4.82e-04	159	43	3	af137688e06a97ff97bb7def54f0dd164d155b11
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KDR FLT1 MROH2A	4.82e-04	159	43	3	c960df9e4fa980401941866b5081facac4590b4d
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	PDCD11 ARID1B DSEL	5.00e-04	161	43	3	58381131e651744b5141b202f9d6063f55432db5
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ZFYVE26 HEATR6 SZT2	5.09e-04	162	43	3	64353d33af0e82ebb7cf2bba74d52ca0586a58fc
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_4\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ZFYVE26 HEATR6 SZT2	5.18e-04	163	43	3	9f5facfa1864eb63e2f8022ad7379d9252b7a254
ToppCell	frontal_cortex-Non-neuronal-endothelial_cell\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KDR FLT1 CCDC141	5.27e-04	164	43	3	6a41a159134e605b80d5e731f9ed5bc803bb531b
ToppCell	frontal_cortex-Non-neuronal-endothelial_cell-Endo\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KDR FLT1 CCDC141	5.27e-04	164	43	3	ec68954fc09b6850273b5e59caa6b09d02151097
ToppCell	facs-Lung-EPCAM-3m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MTMR3 SZT2 NEK8	5.27e-04	164	43	3	1d0d88132baaa3154c3e6e4ef0aff795afab08a2
ToppCell	facs-Lung-EPCAM-3m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MTMR3 SZT2 NEK8	5.27e-04	164	43	3	bd2e10b015d5e6a338675500ec5d81dc39583b3e
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|356C / Donor, Lineage, Cell class and subclass (all cells)	CCDC141 DOCK11 NEK8	5.46e-04	166	43	3	c4f7ea1cad962b1d6ad77423d15978b68a0d6f1d
ToppCell	wk_20-22-Hematologic-Myeloid-Mast\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CDK15 CCDC141 ZNF738	5.46e-04	166	43	3	004ab6a1425d812c7ce572205875fd702d4a9659
ToppCell	frontal_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Ctla2a\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KDR FLT1 CCDC141	5.46e-04	166	43	3	27af6c906cff1d40d134f0386db7708869691121
ToppCell	368C-Myeloid-Dendritic-pDC\|368C / Donor, Lineage, Cell class and subclass (all cells)	ERN1 NEK8 DOP1B	5.56e-04	167	43	3	1e2fc1637769405a61f4c7e44945712a1888a299
ToppCell	control-Myeloid-pDC\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	EPHB6 CCDC141 SZT2	5.66e-04	168	43	3	affc39c7568b7df4b36af6f5b0e3702a18b6268c
ToppCell	(3)_DC_plasmacytoid\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	ABCD1 ERN1 NEK8	5.66e-04	168	43	3	8a913db9b2a1a4ff96fb139734a3834e6aa263f1
ToppCell	(3)_MNP-(3)_DC_plasmacytoid\|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)	ABCD1 ERN1 NEK8	5.66e-04	168	43	3	13c160ea1a19b47d2e7e2dae818c8dcde4e3e377
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KDR FLT1 DOCK9	5.75e-04	169	43	3	987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KDR DOCK9 STON2	5.75e-04	169	43	3	8a6d05b5d60b2b2e43a8ff7521feb79cd6dbd940
ToppCell	368C-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	DSEL NEK8 DOP1B	5.95e-04	171	43	3	714a0b0d0c9886fef64170cf53eb64f0d8a47280
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KDR FLT1 DOCK9	5.95e-04	171	43	3	b3e6e31dfe3623b960ccf692fdbd236fa4039923
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CCDC141 DOCK11 NEK8	6.06e-04	172	43	3	a9e13aa36087170dadca421ba9de588e5a1cf715
ToppCell	356C-Lymphocytic-ILC-ILC-2\|ILC / Donor, Lineage, Cell class and subclass (all cells)	HEATR6 KIAA2013 PROX2	6.06e-04	172	43	3	4977e1f4deae781750e27a8054deccd336cfb74a
ToppCell	Control-Endothelial_cells-Systemic_venous_endothelial_cells\|Control / group, cell type (main and fine annotations)	KDR FLT1 DOCK9	6.06e-04	172	43	3	c55dce1ed3ed7312394b4e050e1de852a994e130
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KDR DOCK9 STON2	6.16e-04	173	43	3	7dc988fc0ba29990567bf1bcdeb3faeeee507eb1
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	KDR FLT1 DOCK9	6.26e-04	174	43	3	cb0109661e8c9ca04d67d33f2d926f0e649bf67d
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KDR FLT1 DOCK9	6.26e-04	174	43	3	6b5ff1cc5fe6705f7ea70b5a892dfbf91e32288d
ToppCell	facs-Heart-RV-18m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDR FLT1 DOCK9	6.47e-04	176	43	3	fb3d03f64592e1df1d9785d9f2e70938d7ff9ce8
ToppCell	facs-Heart-RV-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDR FLT1 DOCK9	6.47e-04	176	43	3	3270a36fc91a5583646ffeb70bfcbc5af7292aac
ToppCell	facs-Heart-RV-18m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDR FLT1 DOCK9	6.47e-04	176	43	3	99410c121f55adbc7fcc013c8fa8905a45dba76b
ToppCell	facs-Aorta\|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDR FLT1 MROH2A	6.47e-04	176	43	3	0b3491451be02c18a16cdb875645be47eb867a7f
ToppCell	COVID-19-Heart-Lymph_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	KDR DOCK9 STON2	6.58e-04	177	43	3	326fde0734ef0d7272693966d346ca479b9d8147
ToppCell	facs-Aorta-Heart-24m-Endothelial-nan\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDR FLT1 DOCK9	6.58e-04	177	43	3	c6b955765aee8a196fcf4f7bb16139c95b76dc4e
ToppCell	PSB-critical-LOC-Myeloid-Basophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CDK15 CCDC141 DOCK11	6.69e-04	178	43	3	45bdbb96094c97756e1b6eebd80eadd8472143f2
ToppCell	facs-Aorta-Heart-24m-Endothelial-aortic_endothelial_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDR FLT1 DOCK9	6.69e-04	178	43	3	8017aaecd6275d8173c516f6f3a68ea991f3c1b0
ToppCell	facs-Aorta-Heart-24m-Endothelial\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDR FLT1 DOCK9	6.69e-04	178	43	3	46333db0d205580189062bf9df839c97196ad161
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	KDR FLT1 DOCK9	6.69e-04	178	43	3	c227da59dc7beb73f84405bf13356bdeb59d9338
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	KDR DOCK9 STON2	6.80e-04	179	43	3	35fe9961e228ce255e3317fc244efa35b5adbf8b
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KDR CCDC141 STON2	6.80e-04	179	43	3	abc6797bd3884aa75dca58fcb2523ee321243ab1
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KDR CCDC141 STON2	6.80e-04	179	43	3	0b996d6e881f31e6b80d359f7caac70ecdeb9982
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DSEL CCDC141 DOCK9	6.80e-04	179	43	3	40c65e8623547aeb80f9cd2366e29072467ce069
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	KDR DOCK9 STON2	6.80e-04	179	43	3	ab3d08b51cd7a37582305615ee221c7a2af83b40
ToppCell	ILEUM-non-inflamed-(7)_Lymphatics\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	KDR DOCK9 STON2	6.80e-04	179	43	3	99777a8931356d1206b8ab22aaa1b1d5a600b809
ToppCell	wk_08-11-Endothelial-Blood_vessel_endothelial-Venous_endo\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	KDR FLT1 DOCK9	6.80e-04	179	43	3	040a7e916baaf81f44339dc721ab2afcd2c22388
ToppCell	367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|367C / Donor, Lineage, Cell class and subclass (all cells)	KDR FLT1 DOCK9	6.91e-04	180	43	3	162cec1734e560c068cd61717e40e18dcf92308c
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KDR FLT1 DOCK9	6.91e-04	180	43	3	755050226eeb1991ee7f0d15e39d0458f3e4a791
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KDR FLT1 DOCK9	6.91e-04	180	43	3	16728b9a1c52097e3a460534be71a476ecc54f0f
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KDR FLT1 GTF2A1L	6.91e-04	180	43	3	455d1e3ccf2ab609954f3b870e8f514ddca735f4
ToppCell	Control-Endothelial_cells-Capillary_endothelial_cells\|Control / group, cell type (main and fine annotations)	KDR FLT1 DOCK9	6.91e-04	180	43	3	b043f9ffb9a4cd427a15bebb86a711c7b08866e8
ToppCell	3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KDR FLT1 DOCK9	6.91e-04	180	43	3	efc4c5a4dea456527526bbfd88cf70d803893671
ToppCell	droplet-Liver-LIVER_HEP\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDR FLT1 LRRK2	6.91e-04	180	43	3	423454e3390080ae03bb3cbb267255ebfe4df080
ToppCell	367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	KDR FLT1 DOCK9	6.91e-04	180	43	3	33c86c22ba877358cd8c1e39b5c0b3dc3a45b7dd
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KDR FLT1 DOCK9	6.91e-04	180	43	3	97e0dcb7cfbba60a782824c5e23995058609fcd4
ToppCell	droplet-Liver-LIVER_HEP-30m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDR FLT1 LRRK2	6.91e-04	180	43	3	dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 NRK LRRK2	7.02e-04	181	43	3	9d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCell	COPD-Endothelial-VE_Capillary_A\|World / Disease state, Lineage and Cell class	KDR FLT1 DOCK9	7.02e-04	181	43	3	61608123959483ff60f07d8467996853c4371b6a
ToppCell	COVID-19-Endothelial_cells-Capillary_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	KDR FLT1 DOCK9	7.02e-04	181	43	3	c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDR FLT1 PDPR	7.02e-04	181	43	3	4df7972f88117108698efd06b124b232f8588981
ToppCell	COVID-19-Endothelial_cells-Endothelial_cells_(other)\|COVID-19 / group, cell type (main and fine annotations)	KDR FLT1 DOCK9	7.02e-04	181	43	3	26eb4ee57a70dbf54e096b73129fda9dfda1f6ec
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	ARID1B HERC1 NFKB1	7.02e-04	181	43	3	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDR FLT1 PDPR	7.02e-04	181	43	3	cbb530566893281289026bfd93adf721decd4ca3
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KDR FLT1 DOCK9	7.13e-04	182	43	3	d0e3663f7d39f22a3ebd7fde56ab3504773598f4
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KDR FLT1 DOCK9	7.13e-04	182	43	3	a20017b6a4f9a6a29e090e4dbd7c02ed1495bd50
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDR FLT1 CCDC141	7.13e-04	182	43	3	ccc313ecc0bfd8e2c6bb83a565b427b2310485ec
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDR FLT1 CCDC141	7.13e-04	182	43	3	e6a734fb29105093d4cbfc3d0619a825b66da034
ToppCell	facs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KDR CCDC141 DOCK9	7.13e-04	182	43	3	d22ab50b135482915687c70e6dad29bfe2bb2c68
ToppCell	droplet-Fat-Scat-18m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDR FLT1 DOCK9	7.13e-04	182	43	3	fea094fe0e7796c084e60b5310c1559658633f7a
ToppCell	E16.5-samps-Endothelial-Immature_fetal_endothelial-Intermediate_Endothelial\|E16.5-samps / Age Group, Lineage, Cell class and subclass	KDR FLT1 DOCK9	7.13e-04	182	43	3	fec1caf867b1dc87b24504d895ee1a27df78062e
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDR FLT1 CCDC141	7.13e-04	182	43	3	b9f758961fb4a586ae86fa0b25edb8ce4616d644
ToppCell	10x3'2.3-week_14-16-Endothelial-stroma-proliferating_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	KDR FLT1 DOCK9	7.13e-04	182	43	3	997d37ca2af661c92a56add888762724dfccc890
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D175\|Adult / Lineage, Cell type, age group and donor	KDR FLT1 NRK	7.13e-04	182	43	3	8b4a07ebd7a133a33ef333cfa29d12c4f3d4d9ac
ToppCell	3'-Adult-SmallIntestine-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KDR FLT1 DOCK9	7.25e-04	183	43	3	f8212bf8a8b8312434ae030261c558c147f61747
ToppCell	COPD-Epithelial-ATII\|World / Disease state, Lineage and Cell class	BTBD16 CCDC141 LRRK2	7.25e-04	183	43	3	8e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCell	3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KDR FLT1 DOCK9	7.25e-04	183	43	3	858682df5592c6856487487a7baabd6e60e63a38
Computational	Genes in the cancer module 80.	EPHB6 KDR FLT1	4.65e-05	32	24	3	MODULE_80
Computational	Genes in the cancer module 51.	EPHB6 KDR FLT1	6.65e-05	36	24	3	MODULE_51
Drug	Cortodoxone	CYP11B1 CYP11B2 NFKB1	2.18e-07	7	43	3	ctd:D003350
Drug	3,4,5,3',4',5'-hexachlorobiphenyl	KDR CYP11B1 CYP11B2	1.77e-06	13	43	3	ctd:C027309
Drug	3-(5-methyl-2-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)propionic acid	KDR FLT1	3.48e-06	2	43	2	ctd:C477639
Drug	cyadox	CYP11B1 CYP11B2	3.48e-06	2	43	2	ctd:C020728
Drug	18-hydroxydeoxycorticosterone	CYP11B1 CYP11B2	3.48e-06	2	43	2	ctd:C042509
Drug	O-Ir	KDR FLT1 CYP11B2 NFKB1	4.05e-06	57	43	4	CID000448249
Drug	18-hydroxycortisol	CYP11B1 CYP11B2	1.04e-05	3	43	2	ctd:C033689
Drug	Proanthocyanidins	ERN1 CYP11B1 CYP11B2	1.24e-05	24	43	3	ctd:D044945
Drug	18-hydroxydeoxycorticosterone	ABCD1 CYP11B1 CYP11B2	1.40e-05	25	43	3	CID000064970
Drug	T67416	KDR FLT1	2.09e-05	4	43	2	CID000956683
Drug	C05489	CYP11B1 CYP11B2	2.09e-05	4	43	2	CID000440708
Drug	3-bromoaniline	KDR FLT1	2.09e-05	4	43	2	CID000011562
Drug	17alpha, 21-dihydroxypregnenolone	CYP11B1 CYP11B2	3.47e-05	5	43	2	CID000192735
Drug	3-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one	KDR LRRK2	3.47e-05	5	43	2	ctd:C549541
Drug	Tetrahydronaphthalenes	CYP11B1 CYP11B2	5.20e-05	6	43	2	ctd:D013764
Drug	NA 119	KDR FLT1	5.20e-05	6	43	2	CID000068839
Drug	Methandrostenolone	CYP11B1 CYP11B2	5.20e-05	6	43	2	ctd:D008696
Drug	P-320	KDR FLT1	5.20e-05	6	43	2	CID000203773
Drug	imetelstat	KDR FLT1	7.27e-05	7	43	2	ctd:C519562
Drug	axitinib	KDR FLT1	7.27e-05	7	43	2	ctd:C503983
Drug	Sunitinib	KDR FLT1	9.69e-05	8	43	2	DB01268
Drug	2,2',3,3',4,6'-hexachlorobiphenyl	CYP11B1 CYP11B2	9.69e-05	8	43	2	ctd:C094859
Drug	lanreotide	FLT1 NFKB1	9.69e-05	8	43	2	ctd:C060347
Drug	GKT137831	CYP11B1 CYP11B2	1.24e-04	9	43	2	ctd:C576694
Drug	2,2',3,4',5',6-hexachlorobiphenyl	CYP11B1 CYP11B2	1.24e-04	9	43	2	ctd:C120129
Drug	5-hydroxydecanoic acid	FLT1 NFKB1	1.55e-04	10	43	2	ctd:C052853
Drug	Indans	CYP11B1 CYP11B2	1.55e-04	10	43	2	ctd:D007189
Drug	9 -fluorohydrocortisone acetate	FLT1 ABCD1	1.55e-04	10	43	2	CID000003370
Drug	perflubron	CYP11B1 CYP11B2	1.55e-04	10	43	2	ctd:C003072
Drug	Cloprostenol	KDR FLT1	1.90e-04	11	43	2	ctd:D003008
Drug	SU11652	KDR FLT1	1.90e-04	11	43	2	CID005329103
Drug	2,3,3',4,4',5-hexachlorobiphenyl	CYP11B1 CYP11B2	1.90e-04	11	43	2	ctd:C087667
Drug	pazopanib	KDR FLT1	2.27e-04	12	43	2	ctd:C516667
Drug	CB149	CYP11B1 CYP11B2	2.27e-04	12	43	2	CID000038016
Drug	fumagillol	KDR FLT1	2.27e-04	12	43	2	CID000130042
Drug	dGprG2'OMe	KDR FLT1	2.27e-04	12	43	2	CID000474412
Drug	wogonin	KDR FLT1 NFKB1	2.30e-04	63	43	3	CID005281703
Drug	1H,1H,2H,2H-perfluorodecanol	CYP11B1 CYP11B2	2.68e-04	13	43	2	ctd:C033729
Drug	CEP-7055	KDR FLT1	2.68e-04	13	43	2	CID000216386
Drug	poly(I-C	FLT1 EIF2AK1 NRK NFKB1	3.02e-04	171	43	4	CID000213546
Drug	fascaplysine	KDR FLT1	3.13e-04	14	43	2	ctd:C069346
Drug	D 2163	KDR FLT1	3.13e-04	14	43	2	CID000148203
Disease	adrenal cortical adenoma (is_marker_for)	CYP11B1 CYP11B2	1.98e-06	2	42	2	DOID:0050891 (is_marker_for)
Disease	Glucocorticoid-remediable aldosteronism	CYP11B1 CYP11B2	1.98e-06	2	42	2	C1260386
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	KDR FLT1 ERN1 CDK15 LRRK2	2.17e-06	148	42	5	C0279702
Disease	cerebral cavernous malformation (is_marker_for)	KDR FLT1	5.93e-06	3	42	2	DOID:0060669 (is_marker_for)
Disease	allergic contact dermatitis (is_marker_for)	KDR FLT1	5.93e-06	3	42	2	DOID:3042 (is_marker_for)
Disease	arteriovenous malformations of the brain (is_marker_for)	KDR FLT1	5.93e-06	3	42	2	DOID:0060688 (is_marker_for)
Disease	congenital adrenal hyperplasia (implicated_via_orthology)	CYP11B1 CYP11B2	5.93e-06	3	42	2	DOID:0050811 (implicated_via_orthology)
Disease	primary hyperaldosteronism (is_implicated_in)	CYP11B1 CYP11B2	1.97e-05	5	42	2	DOID:446 (is_implicated_in)
Disease	Conn Syndrome	CYP11B1 CYP11B2	2.96e-05	6	42	2	C1384514
Disease	Hyperaldosteronism	CYP11B1 CYP11B2	2.96e-05	6	42	2	C0020428
Disease	protocadherin alpha-7 measurement	CYP11B1 CYP11B2	4.13e-05	7	42	2	EFO_0801973
Disease	protein FAM163B measurement	CYP11B1 CYP11B2	7.08e-05	9	42	2	EFO_0802936
Disease	androstenedione measurement	CYP11B1 CYP11B2	8.84e-05	10	42	2	EFO_0007972
Disease	3-hydroxyanthranilate 3,4-dioxygenase measurement	CYP11B1 CYP11B2	1.08e-04	11	42	2	EFO_0021862
Disease	cell growth regulator with EF hand domain protein 1 measurement	CYP11B1 CYP11B2	1.08e-04	11	42	2	EFO_0801461
Disease	thyroid gland carcinoma (is_marker_for)	KDR FLT1	1.29e-04	12	42	2	DOID:3963 (is_marker_for)
Disease	retinopathy of prematurity (biomarker_via_orthology)	KDR FLT1	1.29e-04	12	42	2	DOID:13025 (biomarker_via_orthology)
Disease	macular retinal edema (is_marker_for)	KDR FLT1	1.29e-04	12	42	2	DOID:4449 (is_marker_for)
Disease	Adenocarcinoma of lung (disorder)	KDR FLT1 EIF2AK1 ERN1	2.10e-04	206	42	4	C0152013
Disease	Schwartz-Jampel Syndrome, Type 1	KDR FLT1	2.34e-04	16	42	2	C4551479
Disease	Spondyloepiphyseal Dysplasia	KDR FLT1	2.34e-04	16	42	2	C0038015
Disease	Schwartz-Jampel Syndrome	KDR FLT1	2.34e-04	16	42	2	C0036391
Disease	Melnick-Needles Syndrome	KDR FLT1	2.34e-04	16	42	2	C0025237
Disease	Spondyloepiphyseal Dysplasia Tarda, X-Linked	KDR FLT1	2.34e-04	16	42	2	C3541456
Disease	Van Buchem disease	KDR FLT1	2.65e-04	17	42	2	C0432272
Disease	Kuhnt-Junius degeneration (is_implicated_in)	KDR FLT1	2.65e-04	17	42	2	DOID:10873 (is_implicated_in)
Disease	Uremia	KDR FLT1	2.65e-04	17	42	2	C0041948
Disease	Hemangiosarcoma	KDR FLT1	2.98e-04	18	42	2	C0018923
Disease	hypertension (biomarker_via_orthology)	KDR ARID1B CYP11B1 CYP11B2	3.04e-04	227	42	4	DOID:10763 (biomarker_via_orthology)
Disease	Dyschondroplasias	KDR FLT1	3.33e-04	19	42	2	C0013366
Disease	Osteochondrodysplasias	KDR FLT1	3.33e-04	19	42	2	C0029422
Disease	Multiple Epiphyseal Dysplasia	KDR FLT1	3.70e-04	20	42	2	C0026760
Disease	Infiltrating duct carcinoma of female breast	CDK15 NRK	4.08e-04	21	42	2	C3165106
Disease	Ovarian Serous Adenocarcinoma	ERN1 LRRK2	4.91e-04	23	42	2	C1335177
Disease	cancer (implicated_via_orthology)	KDR FLT1 ARID1B PROX2	5.68e-04	268	42	4	DOID:162 (implicated_via_orthology)
Disease	apolipoprotein L1 measurement	CYP11B1 CYP11B2	5.81e-04	25	42	2	EFO_0021854
Disease	pre-eclampsia (is_implicated_in)	FLT1 CYP11B2	5.81e-04	25	42	2	DOID:10591 (is_implicated_in)
Disease	Cerebral Hemorrhage	KDR FLT1	7.30e-04	28	42	2	C2937358
Disease	amyotrophic lateral sclerosis (is_marker_for)	KDR LRRK2	7.84e-04	29	42	2	DOID:332 (is_marker_for)
Disease	Ovarian Mucinous Adenocarcinoma	EPHB6 LRRK2	8.96e-04	31	42	2	C1335167
Disease	brain infarction (biomarker_via_orthology)	CYP11B1 CYP11B2	1.02e-03	33	42	2	DOID:3454 (biomarker_via_orthology)
Disease	melanoma (is_marker_for)	KDR FLT1	1.02e-03	33	42	2	DOID:1909 (is_marker_for)
Disease	lung non-small cell carcinoma (is_implicated_in)	KDR ARID1B NFKB1	1.03e-03	139	42	3	DOID:3908 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
IHLHKIPQDLLHKVL	BTBD16	246	Q32M84
LVLILGKLILLHHEH	ARID1B	2041	Q8NFD5
LEAILDVVHLHHILQ	ABCD1	576	P33897
ILHDKIIDLVHLLLR	MAGEA11	221	P43364
LLHCHTLLLEKEVVH	MMS19	76	Q96T76
LLKLLQVLIVLEHHL	DOP1B	1441	Q9Y3R5
DLKLLFVHVHHLINE	MED7	111	O43513
SVALLHKHLQLLLPH	HERC1	1011	Q15751
IILVLALLETSLLHH	PCNX4	361	Q63HM2
KVAELHHLLNVHDLV	PDPR	161	Q8NCN5
NHLVSKVSQLIHHLL	HEATR6	91	Q6AI08
QILLALHHVHTHLIL	NEK8	111	Q86SG6
ISVHLEHLEKLELHQ	LRRK2	1006	Q5S007
VILHLSHLLHLDASI	PRNT	11	Q86SH4
QILHLEQLHHFLKLK	ODAD1	216	Q96M63
LHLLKQQLRHLQEHI	PROX2	136	Q3B8N5
ILHLEHDLVHVTRKN	CENPB	571	P07199
HELKLLVRNIHVLLL	C2CD2	261	Q9Y426
LLQLHEHHTKELLER	CCDC141	166	Q6ZP82
IELPIHLHQKHHLLF	DOCK11	716	Q5JSL3
HVLHSLLLAIIPHVT	DOCK11	996	Q5JSL3
HHIHLHLRQQKELLI	DOCK3	861	Q8IZD9
IELPTQLHEKHHLLL	DOCK9	716	Q9BZ29
LKHANIVLLHDIIHT	CDK15	156	Q96Q40
QLLLVSLLEHLSHVH	EIF2AK1	66	Q9BQI3
INMHDLHRLLLHLLL	EFCAB6	761	Q5THR3
LAHLHSLNIVHRDLK	ERN1	676	O75460
LLLLHHVLKHLQVET	CYP11B1	461	P15538
LLLLHHVLKHFLVET	CYP11B2	461	P19099
LVQDTKLHLQNIHLH	DSEL	926	Q8IZU8
HHLSVLLKSALLVVH	MTMR3	386	Q13615
RLLIDGILLLAHHHQ	MROH2A	1141	A6NES4
HHVLLPLHLDTQVLI	NRK	596	Q7Z2Y5
LRLVHQHVLGAHLVL	SZT2	3051	Q5T011
KLLHHIQLLQQHLRQ	EPHB6	1001	O15197
LQHHVLTRIHILSFL	STON2	591	Q8WXE9
LLKLEVHVSLHQDLV	PDCD11	901	Q14690
LLHLGQHKIIHIREN	ZNF738	216	Q8NE65
ALHQHVTDIQLHILK	GTF2A1L	286	Q9UNN4
LKILIHIGHHLNVVN	KDR	886	P35968
ILTHIGHHLNVVNLL	FLT1	881	P17948
HLISLHQKHLLHLLE	ZFYVE26	1576	Q68DK2
LTHLQDLRHTLHLKA	KIAA2013	561	Q8IYS2
VLHLAIIHLHSQLVR	NFKB1	546	P19838