Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	DVL-1	DVL1P1 DVL1	2.17e-06	2	28	2	IPR008340
Domain	Dishevelled	DVL1P1 DVL1	1.30e-05	4	28	2	PF02377
Domain	Dishevelled_protein_dom	DVL1P1 DVL1	1.30e-05	4	28	2	IPR003351
Domain	Dishevelled_fam	DVL1P1 DVL1	1.30e-05	4	28	2	IPR008339
Domain	DIX	DVL1P1 DVL1	4.53e-05	7	28	2	IPR001158
Domain	DIX	DVL1P1 DVL1	4.53e-05	7	28	2	PS50841
Domain	DAX	DVL1P1 DVL1	4.53e-05	7	28	2	SM00021
Domain	DIX	DVL1P1 DVL1	4.53e-05	7	28	2	PF00778
Domain	RasGAP	RASA2 SYNGAP1	1.95e-04	14	28	2	SM00323
Domain	RasGAP_CS	RASA2 SYNGAP1	1.95e-04	14	28	2	IPR023152
Domain	RAS_GTPASE_ACTIV_2	RASA2 SYNGAP1	2.25e-04	15	28	2	PS50018
Domain	RasGAP	RASA2 SYNGAP1	2.25e-04	15	28	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	RASA2 SYNGAP1	2.25e-04	15	28	2	PS00509
Domain	-	RASA2 SYNGAP1	2.57e-04	16	28	2	1.10.506.10
Domain	RasGAP_dom	RASA2 SYNGAP1	3.27e-04	18	28	2	IPR001936
Domain	DEP	DVL1P1 DVL1	4.91e-04	22	28	2	PF00610
Domain	DEP	DVL1P1 DVL1	4.91e-04	22	28	2	SM00049
Domain	DEP	DVL1P1 DVL1	4.91e-04	22	28	2	PS50186
Domain	DEP_dom	DVL1P1 DVL1	5.38e-04	23	28	2	IPR000591
Domain	TSP_1	ADAMTS18 C8B	4.00e-03	63	28	2	PF00090
Domain	TSP1	ADAMTS18 C8B	4.25e-03	65	28	2	SM00209
Domain	TSP1_rpt	ADAMTS18 C8B	4.25e-03	65	28	2	IPR000884
Domain	TSP1	ADAMTS18 C8B	4.25e-03	65	28	2	PS50092
Domain	PH	APPL2 RASA2 SYNGAP1	4.75e-03	229	28	3	PF00169
Domain	Rho_GTPase_activation_prot	RASA2 SYNGAP1	7.66e-03	88	28	2	IPR008936
Domain	PH	APPL2 RASA2 SYNGAP1	8.12e-03	278	28	3	SM00233
Domain	PH_DOMAIN	APPL2 RASA2 SYNGAP1	8.20e-03	279	28	3	PS50003
Domain	PH_domain	APPL2 RASA2 SYNGAP1	8.28e-03	280	28	3	IPR001849
Pubmed	Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.	DVL1P1 DVL1	7.69e-07	2	31	2	8644734
Pubmed	cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.	DVL1P1 DVL1	4.61e-06	4	31	2	8817329
Pubmed	Human dishevelled genes constitute a DHR-containing multigene family.	DVL1P1 DVL1	4.61e-06	4	31	2	9192851
Pubmed	Non-canonical Wnt signaling induces ubiquitination and degradation of Syndecan4.	DVL1P1 DVL1	4.61e-06	4	31	2	20639201
Pubmed	A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5).	DVL1P1 DVL1	2.15e-05	8	31	2	19643732
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	PKM SLK DLGAP5 DVL1	7.72e-05	256	31	4	33397691
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	PKM CCT7 SLK NOP2 DLGAP5 YLPM1	1.53e-04	934	31	6	33916271
Pubmed	Ubiquitin-protein ligase E3C maintains non-small-cell lung cancer stemness by targeting AHNAK-p53 complex.	PKM CCT7	1.60e-04	21	31	2	30503554
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	PKM CCT7 YLPM1	3.49e-04	154	31	3	16055720
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	PKM CCT7 RASA2 NOP2 YLPM1	3.61e-04	701	31	5	30196744
Pubmed	Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models.	HORMAD2 SLC25A31	3.75e-04	32	31	2	27739607
Pubmed	Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling.	PKM DVL1P1 DVL1	3.98e-04	161	31	3	36398662
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	POGLUT3 POLD3 TTLL4 DLGAP5 YLPM1	4.42e-04	733	31	5	34672954
Pubmed	Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).	POLD3 DLGAP5	5.02e-04	37	31	2	7584028
Pubmed	TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.	PKM CCT7 NOP2 DLGAP5	5.57e-04	430	31	4	38172120
Pubmed	Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.	PKM FAM83G CCT7 NOP2	5.66e-04	432	31	4	23455922
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	PKM CCT7 SLK SLC30A5	6.54e-04	449	31	4	31732153
Pubmed	Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.	POLD3 DLGAP5	6.79e-04	43	31	2	7584026
Pubmed	The N-terminal domain of the Schaaf-Yang syndrome protein MAGEL2 likely has a role in RNA metabolism.	PKM SLK	7.77e-04	46	31	2	34265304
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	PKM CCT7 VWF APPL2 YLPM1 SYNGAP1	8.37e-04	1285	31	6	35914814
Cytoband	7p22.1	RSPH10B2 RSPH10B	4.68e-04	47	31	2	7p22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr7p22	RSPH10B2 RSPH10B	3.72e-03	134	31	2	chr7p22
Cytoband	Ensembl 112 genes in cytogenetic band chr12q23	APPL2 TTC41P	4.63e-03	150	31	2	chr12q23
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA2 SYNGAP1	6.32e-05	10	22	2	830
GeneFamily	Solute carriers	SLC30A5 SLC13A1 SLC25A31	1.17e-02	395	22	3	752
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	POLD3 YLPM1	2.02e-02	181	22	2	694
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	APPL2 RASA2	2.57e-02	206	22	2	682
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PKM SLK SULT2B1 DLGAP5	1.02e-05	197	31	4	fb272c9c60ee3d980e528044dc567b4925a23da6
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PKM SLK SULT2B1 DLGAP5	1.02e-05	197	31	4	61c0d78b29dc4ad8a84172cbfcdab03f31351d0e
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PKM SLK SULT2B1 DLGAP5	1.02e-05	197	31	4	dcabea5c50c133c9a4e294e447462d0393174ea7
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PKM SLK SULT2B1 DLGAP5	1.04e-05	198	31	4	e06d41a7254a09e037ec404be2d8c352d5cbd7f4
Disease	DiGeorge syndrome (is_implicated_in)	DVL1P1 DVL1	9.31e-06	5	29	2	DOID:11198 (is_implicated_in)
Disease	myocardial infarction (biomarker_via_orthology)	DVL1P1 VWF C8B DVL1	1.78e-05	160	29	4	DOID:5844 (biomarker_via_orthology)
Disease	renal cell carcinoma	POGLUT3 SLK	7.84e-04	42	29	2	EFO_0000681
Disease	lung carcinoma, estrogen-receptor negative breast cancer, ovarian endometrioid carcinoma, colorectal cancer, prostate carcinoma, ovarian serous carcinoma, breast carcinoma, ovarian carcinoma, lung adenocarcinoma, squamous cell lung carcinoma	DVL1P1 DVL1	1.20e-03	52	29	2	EFO_0000305, EFO_0000571, EFO_0000708, EFO_0001071, EFO_0001075, EFO_0001663, EFO_1000650, EFO_1001515, EFO_1001516, MONDO_0005575
Disease	nicotine dependence	DVL1P1 DVL1	2.67e-03	78	29	2	EFO_0003768
Disease	Drug Use Disorders	SLK APPL2	5.71e-03	115	29	2	C0013222
Disease	Drug Dependence	SLK APPL2	5.71e-03	115	29	2	C1510472
Disease	Drug habituation	SLK APPL2	5.71e-03	115	29	2	C0013170
Disease	Substance Dependence	SLK APPL2	5.71e-03	115	29	2	C0038580
Disease	Substance Use Disorders	SLK APPL2	5.71e-03	115	29	2	C0038586
Disease	Substance-Related Disorders	SLK APPL2	5.71e-03	115	29	2	C0236969
Disease	Drug abuse	SLK APPL2	5.71e-03	115	29	2	C0013146
Disease	Organic Mental Disorders, Substance-Induced	SLK APPL2	5.71e-03	115	29	2	C0029231
Disease	Prescription Drug Abuse	SLK APPL2	5.71e-03	115	29	2	C4316881
Disease	Substance abuse problem	SLK APPL2	5.80e-03	116	29	2	C0740858
Disease	white matter microstructure measurement	SLK C8B TTLL4	6.49e-03	390	29	3	EFO_0005674
Disease	melanoma	POGLUT3 SLK	6.81e-03	126	29	2	EFO_0000756
Disease	white matter integrity	ADAMTS18 SLK	7.23e-03	130	29	2	EFO_0004641

Protein segments in the cluster

Peptide	Gene	Start	Entry
YTFGKDFKQNFDLMK	ZNF354C	191	Q86Y25
CKAENFEFFFAMSGK	ADAMTS18	686	Q8TE60
FEFFFAMSGKVKDGT	ADAMTS18	691	Q8TE60
KSKSSFKETFMCEFF	RASA2	556	Q15283
SKMNFKLTGKGITFF	RSPH10B	726	P0C881
SKMNFKLTGKGITFF	RSPH10B2	726	B2RC85
QFKFKYTKEGATMDF	HORMAD2	121	Q8N7B1
NFAMNVGKARGFFKK	PKM	491	P14618
FAFKDKYKQLFMSGV	SLC25A31	101	Q9H0C2
FFFMSQVLPAKGKFK	DEFB108A	11	A8MXU0
IKGKNSFAPKDFMFQ	DLGAP5	301	Q15398
GQINFFKKGAEMFSK	APPL2	206	Q8NEU8
KFFFKSMDQDFGVVK	DVL1	46	O14640
KFFFKSMDQDFGVVK	DVL1P1	46	P54792
LFLGFNFKEMFKCGK	SLC13A1	306	Q9BZW2
EKMASKSGFSFGFKI	C8B	246	P07358
SATKFKGALAQKFMF	FAM83G	246	A6ND36
MSFFNFRKIFKLGSE	SLK	1	Q9H2G2
FTKAFFSSKAKVIYM	SULT2B1	131	O00204
FKKTFSYAGFEMQPK	CCT7	216	Q99832
SNFFGKAAMNKFKVN	POLD3	236	Q15054
MDGFFIAKFKKFSNS	NOP2	576	P46087
KELGKAKLMGFFDFF	POGLUT3	351	Q7Z4H8
YFDEMKSFAKAFISK	VWF	1706	P04275
KFLCFMKGHFDNLFS	MIS12	66	Q9H081
FSKFTSKEDFLGFMN	SYNGAP1	636	Q96PV0
MFLSAVFFAKSKSKN	MRPL33	1	O75394
FFIGSFLKFMGKTNE	TTC41P	821	Q6P2S7
TSMFKTFKKTLDDGF	YLPM1	1911	P49750
AFFMVLFQKPFSSGK	SLC30A5	71	Q8TAD4
KFKFFKFKGFGSLSN	SH2D3C	11	Q8N5H7
MQSRFGKKEFSFFPQ	TTLL4	681	Q14679